Research Topics
| M MerliSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Cardiac dysfunction in cirrhosis is not associated with the severity of liver diseaseManuela Merli
Gastroenterologia, Dipartimento Medicina Clinica, Sapienza Universita di Roma, Italy
Eur J Intern Med 24:172-6. 2013..Cirrhotic cardiomiopathy is described as the presence of cardiac dysfunction in cirrhotic patients. The aim of the study was to investigate factors associated with cardiac dysfunction in cirrhotic patients...- Cirrhotic patients are at risk for health care-associated bacterial infectionsManuela Merli
Division of Gastroenterology, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy
Clin Gastroenterol Hepatol 8:979-85. 2010..We assessed the epidemiology, risk factors, and clinical consequences of bacterial infections in hospitalized cirrhotic patients... - Dietary and nutritional indications in hepatic encephalopathyManuela Merli
II Gastroenterologia, Universita degli Studi di Roma La Sapienza, Rome, Italy
Metab Brain Dis 24:211-21. 2009..The relevance of an adequate protein intake and possible strategies to implement protein tolerance are also discussed... - Conversion from twice-daily to once-daily tacrolimus administration in liver transplant patientM Merli
Centro Trapianti Policlinico Umberto I La Sapienza, Roma
Transplant Proc 42:1322-4. 2010..The present study was sought to evaluate the feasibility of this formulation among liver transplantation patients (OLT)... 
Predictive factors of outcome after liver transplantation in patients with cirrhosis and hepatocellular carcinomaM Merli
II Gastroenterologia, Universita La Sapienza, Rome, Italy
Transplant Proc 37:2535-40. 2005..The adoption of Milan criteria for selection of cirrhotic patients has improved survival and reduced the rate of tumor recurrence. The evaluation of cumulative tumor size might further improve patient selection...- Ribavirin priming improves the virological response to antiviral treatment in transplanted patients with recurrent hepatitis C: a pilot studyManuela Merli
II Gastroenterologia, Policlinico Umberto I, Sapienza, Universita di Roma, Rome, Italy
Antivir Ther 16:879-85. 2011..Our pilot study was aimed at evaluating whether 8-week ribavirin pre-treatment could increase either adherence or antiviral effect of a 48-week combination therapy... - Incidence and natural history of small esophageal varices in cirrhotic patientsManuela Merli
II Gastroenterology Unit, Department of Clinical Medicine, University of Rome La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
J Hepatol 38:266-72. 2003..The incidence and natural history of small esophageal varices (EV) in cirrhotics may influence the frequency of endoscopies and the decision to start a pharmacological treatment in these patients... - Nutritional status: its influence on the outcome of patients undergoing liver transplantationManuela Merli
II Gastroenterologia Policlinico Umberto I, Universita di Roma La Sapienza, Rome, Italy
Liver Int 30:208-14. 2010..The impact of the recipients' malnutrition on the outcome of liver transplantation (LT) is still under debate and recent studies have shown controversial results... - Immune-mediated liver dysfunction after antiviral treatment in liver transplanted patients with hepatitis C: allo or autoimmune de novo hepatitis?M Merli
II Gastroenterologia, Policlinico Umberto I, Universita di Roma La Sapienza, Rome, Italy
Dig Liver Dis 41:345-9. 2009..It has been recently reported, however, that during antiviral treatment a hepatic immune-mediated liver dysfunction, similar to "de novo" autoimmune hepatitis, may develop in a few transplanted patients... - Acute renal failure in liver transplant recipients: role of pretransplantation renal function and 1-year follow-upF Tinti
Department of Clinical Medicine, Nephrology and Dialysis Unit, Sapienza University of Rome, Rome, Italy
Transplant Proc 43:1136-8. 2011..Although many pre-, peri-, and post-OLT factors may contribute to the development of posttransplantation CRF, pre-OLT CRF seemed to be the most important risk factor... - Bone disorders in patients with chronic liver disease awaiting liver transplantationI Loria
Gastroenterologia, Dipartimento di Medicina Clinica, Policlinico Umberto I, La Sapienza, Roma, Italy
Transplant Proc 42:1191-3. 2010..We also evaluated modifications in bone metabolism after liver transplantation... - RIFLE criteria and hepatic function in the assessment of acute renal failure in liver transplantationF Tinti
DAI Nefro Urologico, Specialità Chirurgiche e Trapianti d Organo Paride Stefanini, Rome, Italy
Transplant Proc 42:1233-6. 2010..Post-OLT CKD may be the result of unrecognized, preexisting CKD and/or the effects of not fully resolved acute damage to an injured kidney... - Combined liver-kidney transplantation in polycystic disease: case reportsM Rossi
Chirurgia Generale E Trapianti d Organo, La Sapienza Universita di Roma, Umberto I Policlinico di Roma, Rome, Italy
Transplant Proc 40:2075-6. 2008..Delaying transplantation results in a more difficult surgical technique, a higher rate of postoperative complications, and a disturbance of optimal graft retrieval because of the worse preoperative condition of the patients... - Impact of anti-hepatitis B core-positive donors in liver transplantation: a survival analysisQ Lai
Department of General Surgery and Organ Transplantation, Sapienza University, Umberto I Hospital, Rome, Italy
Transplant Proc 43:274-6. 2011..The aim of this study was to retrospectively analyze the patient and graft survivals of two groups of OLT recipients according to the anti-HBc status of their respective donors... - Outcome after liver transplantation in patients with cirrhosis and hepatocellular carcinomaM Rossi
Divisione di Chirurgia Generale Trapianti d Organo, Universita La Sapienza, Rome, Italy
Transplant Proc 39:1895-7. 2007..00001). The 58 patients who underwent transplantation with a diagnosis of cirrhosis and concomitant HCC after 1999 showed even better survival than patients who underwent transplantation for end-stage liver disease without malignancy... - Occurrence of chronic renal failure in liver transplantation: monitoring of pre- and posttransplantation renal functionI Umbro
Department of Clinical Medicine, Nephrology and Dialysis Unit, Sapienza University of Rome, Rome, Italy
Transplant Proc 44:1956-9. 2012..Pre-OLT renal dysfunction must be recognized to be a risk factor for post-OLT CRF, representing important criterion to define specific therapeutic interventions to reduce patient morbidity and mortality... - Pharmacological prophylaxis of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a randomized controlled studyO Riggio
Department of Clinical Medicine, University of Rome La Sapienza, Rome, Italy
J Hepatol 42:674-9. 2005..Aim of this study was to compare two different treatments (lactitol 60 g/day, rifaximin 1200 mg/day) with no-treatment in the prevention of post-TIPS hepatic encephalopathy... - Low-dose intramuscular hepatitis B immune globulin and lamivudine for long-term prophylaxis of hepatitis B recurrence after liver transplantationG Ferretti
Dipartimento di Mal. Infettive e Tropicali, Rome, Italy
Transplant Proc 36:535-8. 2004..These preliminary results show that low-dose intramuscular HBIg and lamivudine are efficacious and cost-effective for long-term prophylaxis of hepatitis B recurrence after liver transplantation... - Predictive factors of recurrence of hepatocellular carcinoma after liver transplantation: a multivariate analysisQ Lai
Department of General Surgery and Organ Transplantation, La Sapienza University of Rome, Umberto I Policlinic of Rome, Rome, Italy
Transplant Proc 41:1306-9. 2009..Patients with both these parameters are not candidates for OLT. Microvascular invasion is a good predictive parameter, but is impossible to detect preoperatively. New pre-OLT predictive risk factors are needed to achieve optimal results... - Metabolic syndrome and cardiovascular risk after liver transplantation: a single-center experienceM Iadevaia
Department of Clinical Medicine, Division of Gastroenterology, Sapienza, University of Rome, Rome, Italy
Transplant Proc 44:2005-6. 2012..Close follow-up is mandatory to prevent the development of PTMS mainly among overweight and diabetic patients before transplantation... - Malnutrition is not related to alterations in energy balance in patients with stable liver cirrhosisO Riggio
Department of Clinical Medicine, University of Rome La Sapienza, Italy
Clin Nutr 22:553-9. 2003..Lipid content of the diet was significantly lower in malnourished cirrhotics than in controls (33.1+/-1% vs 37.8+/-1%, P=0.02).CONCLUSIONS: Cirrhotic patients in stable clinical condition with malnutrition show a normal energy balance... - Validation of automated blood cell counter for the determination of polymorphonuclear cell count in the ascitic fluid of cirrhotic patients with or without spontaneous bacterial peritonitisStefania Angeloni
II Gastroenterologia, Dipartimento di Medicina Clinica, , Rome, Italy
Am J Gastroenterol 98:1844-8. 2003..1%, respectively. CONCLUSIONS: The manual method and the automated blood cell counter have a good agreement in the PMN determination in ascitic fluid, and the automated blood cell counter is a reliable tool for rapid diagnosis of SBP... - Clinical efficacy of transjugular intrahepatic portosystemic shunt created with covered stents with different diameters: results of a randomized controlled trialOliviero Riggio
II Gastroenterologia, Dipartimento di Medicina Clinica, La Sapienza Universita di Roma, Italy
J Hepatol 53:267-72. 2010..The aim of this study was to compare the incidence of HE and the clinical efficacy of TIPS created with 8- or 10-mm PTFE-covered stents... 
Accuracy of the automated cell counters for management of spontaneous bacterial peritonitisOliviero Riggio
Dipartimento di Medicina Clinica, Universita di Roma, Viale dell Universita 37, Rome 00185, Italy
World J Gastroenterol 14:5689-94. 2008..To evaluate the accuracy of automated blood cell counters for ascitic polymorphonuclear (PMN) determination for: (1) diagnosis, (2) efficacy of the ongoing antibiotic therapy, and (3) resolution of spontaneous bacterial peritonitis (SBP)...- Incidence, natural history, and risk factors of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt with polytetrafluoroethylene-covered stent graftsOliviero Riggio
II Gastroenterologia, Dipartimento di Medicina Clinica, Sapienza Universita di Roma, Rome, Italy
Am J Gastroenterol 103:2738-46. 2008.... - Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathyOliviero Riggio
Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy
Am J Gastroenterol 105:1374-81. 2010..The aim of this study was to measure indole and oxindole levels in patients with cirrhosis with or without HE and to establish whether an intestinal production and a hepatic metabolism of these substances exist... - Differential vascular endothelial growth factor A protein expression between small hepatocellular carcinoma and cirrhosis correlates with serum vascular endothelial growth factor A and alpha-fetoproteinStefano Ginanni Corradini
Department of Clinical Medicine, GI Unit 2, University of Rome Sapienza, Rome, Italy
Liver Int 29:103-12. 2009.... - Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practiceStefania Angeloni
Department of Clinical Medicine, Sapienza University of Rome, Roma, Italy
World J Gastroenterol 14:2757-62. 2008..To verify the validity of the International Ascites Club guidelines for treatment of spontaneous bacterial peritonitis (SBP) in clinical practice... - Evidence of persistent cognitive impairment after resolution of overt hepatic encephalopathyOliviero Riggio
Department of Clinical Medicine, Center for Diagnosis and Treatment of Portal Hypertension, Sapienza University of Rome, Rome, Italy
Clin Gastroenterol Hepatol 9:181-3. 2011..We tested learning abilities of cirrhotic patients using the Psychometric Hepatic Encephalopathy Score (PHES)... - High prevalence of spontaneous portal-systemic shunts in persistent hepatic encephalopathy: a case-control studyOliviero Riggio
Department of Clinical Medicine, Division of Gastroenterology University of Rome La Sapienza, Rome, Italy
Hepatology 42:1158-65. 2005..In conclusion, our study suggests that large spontaneous shunts may often sustain the chronicity of HE; the presence of large shunts should be sought in patients with cirrhosis with recurrent or persistent HE... - Preharvest donor hyperoxia predicts good early graft function and longer graft survival after liver transplantationStefano Ginanni Corradini
Division of Gastroenterology, Department of Clinical Medicine, University La Sapienza, Rome, Italy
Liver Transpl 11:140-51. 2005..045). In conclusion, preharvest donor hyperoxia predicts IGGF and longer graft survival... - Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathyFrancesca Nicolao
Divisione di Gastroenterologia, Dipartimento di Medicina Clinica, , , 00185 Rome, Italy
J Hepatol 38:441-6. 2003.... - Malnutrition is a risk factor in cirrhotic patients undergoing surgeryManuela Merli
II Gastroenterology, Department of Clinical Medicine, University of Rome La Sapienza, Rome, Italy. l.it
Nutrition 18:978-86. 2002..The limited number of patients and their heterogeneity, however, do not allow definitive conclusions, and more research on this issue is needed... - Polytetrafluoroethylene-covered stent grafts for TIPS procedure: 1-year patency and clinical resultsStefania Angeloni
II Gastroenterologia, Dipartimento di Medicina Clinica, , Italy
Am J Gastroenterol 99:280-5. 2004..Improvements in stent design and insertion techniques are necessary to fully achieve the potential benefit of this new device... - Effect of blood ammonia elevation following oral glutamine load on the psychometric performance of cirrhotic patientsAndrea Masini
Department of Clinical Medicine, University of Rome La Sapienza, Rome, Italy
Metab Brain Dis 18:27-35. 2003..Glutamine challenge is a safe method to induce hyperammonemia in nonencephalopatic cirrhotic patients and, therefore, to study the efficacy of ammonia lowering treatments... - The natural history of portal hypertensive gastropathy in patients with liver cirrhosis and mild portal hypertensionManuela Merli
II Gastroenterology Unit, Department of Clinical Medicine, University of Rome La Sapienza, , 00185 Rome, Italy
Am J Gastroenterol 99:1959-65. 2004..Acute bleeding from portal hypertensive gastropathy is infrequent but may be severe... - Long-term effect of liver transplantation on cirrhotic autonomic cardiac dysfunctionLuigi Baratta
Department of Medicina Clinica Sapienza University, Rome, Italy
Dig Liver Dis 42:131-6. 2010..However, parasympathetic impairment, measured by RMS-SD and LF/HF at night, is not affected even in the long-term after operation... - Glial fibrillary acidic protein as an early marker of hepatic stellate cell activation in chronic and posttransplant recurrent hepatitis CSimone Carotti
Department of Human Anatomy, University of Rome La Sapienza, Italy, Rome
Liver Transpl 14:806-14. 2008..01). In conclusion, GFAP could represent a useful marker of early activation of HSCs in HCV-CH and seems to predict fibrosis progression in HCV-PTR... - A randomized study on Peg-interferon alfa-2a with or without ribavirin in liver transplant recipients with recurrent hepatitis CMario Angelico
Hepatology Unit, Tor Vergata University, Rome, Italy
J Hepatol 46:1009-17. 2007..We performed a randomized trial on pegylated interferon alfa-2a (Peg-IFNalpha) monotherapy vs Peg-IFNalpha and ribavirin in non-cirrhotic liver transplant recipients with recurrent hepatitis C... - Modifications of cardiac function in cirrhotic patients treated with transjugular intrahepatic portosystemic shunt (TIPS)Manuela Merli
Department of Clinical Medicine, University of Rome La Sapienza, Italy
Am J Gastroenterol 97:142-8. 2002.... - Activated hepatic stellate cells in liver cirrhosis. A morphologic and morphometrical studyGuido Carpino
Department of Human Anatomy, University of Rome La Sapienza, Italy
Ital J Anat Embryol 109:225-38. 2004..Alpha-smooth muscle actin confirmed to be a reliable marker of hepatic stellate cells activation also in precocious stages of the disease... - MELD score is better than Child-Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shuntFrancesco Salerno
Department of Internal Medicine, University of Milan, Via Pace 9, 20122 Milan, Italy
J Hepatol 36:494-500. 2002..The aim of this study was to compare model of end-stage liver disease (MELD) and Child-Pugh scores as predictors of survival after TIPS... - QT interval in patients with non-cirrhotic portal hypertension and in cirrhotic patients treated with transjugular intrahepatic porto-systemic shuntFranco Trevisani
Dipartimento di Medicina Interna Cardioangiologia, Epatologia, Alma Mater Studiorum, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
J Hepatol 38:461-7. 2003..A prolonged QT interval is frequent in chronic liver disease and its aetiology remains unsettled. The study's aim was to assess the role of portal hypertension in the pathogenesis of QT prolongation... - Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trialGiulio Marchesini
Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
Gastroenterology 124:1792-801. 2003..The role of oral supplementation with branched-chain amino acids (BCAA) in advanced cirrhosis is far from settled. A nutritional approach might prevent progressive liver failure and improve nutritional parameters and quality of life... - Is hyperammonemia really the true cause of altered neuropsychology, brain MR spectroscopy and magnetization transfer after an oral amino acid load in cirrhosis?Oliviero Riggio
Hepatology 38:777; author reply 778. 2003 - TIPS for patients awaiting orthotopic liver transplantationOliviero Riggio
Liver Transpl 9:999-1000. 2003 - Randomized controlled study of TIPS versus paracentesis plus albumin in cirrhosis with severe ascitesFrancesco Salerno
Department of Internal Medicine, University and Ospedale Maggiore Policlinico Instituto di Ricerca e Cura a Carattere Scientifico IRCCS, Milan, Italy
Hepatology 40:629-35. 2004..In conclusion, compared to large-volume paracentesis plus albumin, TIPS improves survival without liver transplantation in patients with refractory or recidivant ascites... - Failure of hepatitis B vaccination to induce either humoral or cellular immune response after liver transplantation for hepatitis B related cirrhosisManuela Merli
J Hepatol 43:1089-90; author reply 1090. 2005 - GFAP expression in the liver as an early marker of stellate cells activationSergio Morini
Department of Biomedical Researches, University Campus Bio-Medico of Rome
Ital J Anat Embryol 110:193-207. 2005..Otherwise in hepatic stellate cells it seems to be a marker related with the acquisition of contractile properties in a subpopulation more closely associated with precocious stages of the fibrosis... - Endoscopic screening for esophageal varices in cirrhotic patientsOliviero Riggio
Hepatology 35:501-2. 2002