C Merkel

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint Hepatic venous pressure gradient measurement in clinical hepatology
    Carlo Merkel
    Hepatic Haemodynamics Laboratory and Clinica Medica 5, Department of Clinical and Experimental Medicine, University of Padua, and Regional Centre for Hepatology, Padua, Italy
    Dig Liver Dis 43:762-7. 2011
  2. ncbi request reprint A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis
    Carlo Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy
    Gastroenterology 127:476-84. 2004
  3. ncbi request reprint Disagreement between acute and chronic haemodynamic effects of nadolol in cirrhosis: a pathophysiological interpretation
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Aliment Pharmacol Ther 22:433-9. 2005
  4. doi request reprint Clinical significance of worsening portal hypertension during long-term medical treatment in patients with cirrhosis who had been classified as early good-responders on haemodynamic criteria
    Carlo Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    J Hepatol 52:45-53. 2010
  5. doi request reprint Should we routinely measure portal pressure in patients with cirrhosis, using hepatic venous pressure gradient (HVPG) as guidance for prophylaxis and treatment of bleeding and re-bleeding? Yes!
    Carlo Merkel
    Hepatic Haemodynamics Laboratory and Clinica Medica 5, Department of Clinical and Experimental Medicine, University of Padua, Italy
    Eur J Intern Med 22:1-4. 2011
  6. ncbi request reprint Portal hypertension and portal hypertensive gastropathy in patients with liver cirrhosis: a haemodynamic study
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy
    Dig Liver Dis 35:269-74. 2003
  7. ncbi request reprint The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Hepatology 32:930-4. 2000
  8. ncbi request reprint Noninvasive grading of the severity of portal hypertension in cirrhotic patients by echo-color-Doppler
    M Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Ultrasound Med Biol 27:901-7. 2001
  9. ncbi request reprint Long-term results of a clinical trial of nadolol with or without isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis
    C Merkel
    Department of Clinical Medicine, University of Padua, Italy
    Hepatology 31:324-9. 2000
  10. ncbi request reprint Arterioportal fistulas in patients with liver cirrhosis: usefulness of color Doppler US for screening
    M Bolognesi
    Department of Clinical and Experimental Medicine, Clinica Medica 5, Policlinico Universitario, Padova, Italy
    Radiology 216:738-43. 2000

Collaborators

Detail Information

Publications21

  1. doi request reprint Hepatic venous pressure gradient measurement in clinical hepatology
    Carlo Merkel
    Hepatic Haemodynamics Laboratory and Clinica Medica 5, Department of Clinical and Experimental Medicine, University of Padua, and Regional Centre for Hepatology, Padua, Italy
    Dig Liver Dis 43:762-7. 2011
    ..The clinical applications, indications and timing for hepatic venous pressure gradient measurement, together with measurement principles and costs, are reviewed...
  2. ncbi request reprint A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis
    Carlo Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy
    Gastroenterology 127:476-84. 2004
    ..Beta-blockers are extensively used to prevent variceal bleeding in patients with large esophageal varices. It is not established if beta-blockers delay the growth of small varices...
  3. ncbi request reprint Disagreement between acute and chronic haemodynamic effects of nadolol in cirrhosis: a pathophysiological interpretation
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Aliment Pharmacol Ther 22:433-9. 2005
    ..The acute effects of beta-blockers may be different from chronic; mechanisms underlying this difference are poorly elucidated...
  4. doi request reprint Clinical significance of worsening portal hypertension during long-term medical treatment in patients with cirrhosis who had been classified as early good-responders on haemodynamic criteria
    Carlo Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    J Hepatol 52:45-53. 2010
    ..However, it is not known whether the effect remains unchanged over the treatment period...
  5. doi request reprint Should we routinely measure portal pressure in patients with cirrhosis, using hepatic venous pressure gradient (HVPG) as guidance for prophylaxis and treatment of bleeding and re-bleeding? Yes!
    Carlo Merkel
    Hepatic Haemodynamics Laboratory and Clinica Medica 5, Department of Clinical and Experimental Medicine, University of Padua, Italy
    Eur J Intern Med 22:1-4. 2011
    ..Thus, although not necessarily easy to measure, HVPG provides the clinician with information which is prognostically crucial and otherwise unobtainable...
  6. ncbi request reprint Portal hypertension and portal hypertensive gastropathy in patients with liver cirrhosis: a haemodynamic study
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy
    Dig Liver Dis 35:269-74. 2003
    ..The relationships between the levels of portal hypertension and the morphologic alterations of gastric mucosa in patients with liver cirrhosis--generally described as portal hypertensive gastropathy--are poorly defined...
  7. ncbi request reprint The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Hepatology 32:930-4. 2000
    ..In conclusion, the assessment of hemodynamic response to drugs in terms of HVPG is the best predictor of efficacy of prophylaxis of variceal bleeding in patients treated with beta-blockers or beta-blockers plus nitrates...
  8. ncbi request reprint Noninvasive grading of the severity of portal hypertension in cirrhotic patients by echo-color-Doppler
    M Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Ultrasound Med Biol 27:901-7. 2001
    ..066*splenic PI -0.044)*PBF]. In the second group, predicted and observed portal pressure were well correlated (r = 0.71, p = .0003). A good accuracy for the prediction of mild or severe portal hypertension was obtained...
  9. ncbi request reprint Long-term results of a clinical trial of nadolol with or without isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis
    C Merkel
    Department of Clinical Medicine, University of Padua, Italy
    Hepatology 31:324-9. 2000
    ..Side effects are few, and no deleterious effects on ascites occurrence or on survival occur after long-term use of this combination...
  10. ncbi request reprint Arterioportal fistulas in patients with liver cirrhosis: usefulness of color Doppler US for screening
    M Bolognesi
    Department of Clinical and Experimental Medicine, Clinica Medica 5, Policlinico Universitario, Padova, Italy
    Radiology 216:738-43. 2000
    ....
  11. ncbi request reprint Portal hypertension: state of the art
    A Gatta
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Ital J Gastroenterol Hepatol 31:326-45. 1999
    ..Moreover, technological developments have introduced new tools for diagnosis, such as echo-colour-Doppler, and therapy, like variceal banding and transjugular intrahepatic porto-systemic shunt...
  12. ncbi request reprint Clinical features and survivial of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests
    P Amodio
    Clinica Medica V, Department of Clinical and Experimental Medicine, University of Padova, Italy
    Hepatology 29:1662-7. 1999
    ..1-5.3), or altered Choice2 test (hazard ratio = 2.8; CI95% = 1.2-6. 3). Multivariate regression showed that Scan and Choice2 tests had prognostic value on survival, in addition to Child-Pugh classes in the first year of follow-up...
  13. ncbi request reprint Randomized clinical study of the efficacy of amiloride and potassium canrenoate in nonazotemic cirrhotic patients with ascites
    P Angeli
    Department of Clinical Medicine, University of Padua, Italy
    Hepatology 19:72-9. 1994
    ..abstract truncated at 250 words)..
  14. ncbi request reprint Role of spleen enlargement in cirrhosis with portal hypertension
    M Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    Dig Liver Dis 34:144-50. 2002
    ..The increase in spleen size is followed by an increase in splenic blood flow, which participates in portal hypertension actively congesting the portal system...
  15. pmc Haeme oxygenase mediates hyporeactivity to phenylephrine in the mesenteric vessels of cirrhotic rats with ascites
    M Bolognesi
    Clinica Medica 5, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Gut 54:1630-6. 2005
    ..The aim of this study was to verify the role of haeme oxygenase in the hyporesponsiveness to phenylephrine of small mesenteric arteries in rats with CCl(4) induced cirrhosis, with and without ascites...
  16. ncbi request reprint Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients
    P Amodio
    Clinical Medicine 5th, University of Padova, Italy
    J Hepatol 35:37-45. 2001
    ..We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations...
  17. ncbi request reprint Nutrition and survival in patients with liver cirrhosis
    F Alberino
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Nutrition 17:445-50. 2001
    ..These data demonstrate that malnutrition is an independent predictor of survival in patients with liver cirrhosis. The inclusion of anthropometric measures in the assessment of these patients might provide better prognostic information...
  18. ncbi request reprint Switch therapy with ciprofloxacin vs. intravenous ceftazidime in the treatment of spontaneous bacterial peritonitis in patients with cirrhosis: similar efficacy at lower cost
    P Angeli
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Aliment Pharmacol Ther 23:75-84. 2006
    ..Intravenous administration of a third-generation cephalosporin is optimal antibiotic treatment for spontaneous bacterial peritonitis...
  19. doi request reprint Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease
    C Turato
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Dig Liver Dis 41:212-6. 2009
    ..A novel SCCA-1 variant (SCCA-PD), presenting a single mutation in the reactive centre (Gly351Ala), has been recently identified (rs3180227)...
  20. ncbi request reprint New abdominal collaterals at ultrasound: a clue of progression of portal hypertension
    A Berzigotti
    Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Italy
    Dig Liver Dis 40:62-7. 2008
    ..Abdominal portal-systemic collaterals may be protective from the formation and growth of oesophageal varices, but available data are inconclusive...
  21. ncbi request reprint A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis
    D Patch
    Department of Liver Transplantation and Hepatobiliary Medicine, University Department of Surgery, Royal Free Hospital Hampstead NHS Trust, London, UK
    Gastroenterology 123:1013-9. 2002
    ..Since its introduction, endoscopic variceal banding has been shown to be superior to needle sclerotherapy. Banding has not been compared with hepatic venous pressure-guided medical therapy (beta-blockers and nitrates)...