Research Topics
| C MerkelSummaryAffiliation: University of Padova Country: Italy Publications
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Detail Information
Publications
Hepatic venous pressure gradient measurement in clinical hepatologyCarlo Merkel
Hepatic Haemodynamics Laboratory and Clinica Medica 5, Department of Clinical and Experimental Medicine, University of Padua, and Regional Centre for Hepatology, Padua, Italy
Dig Liver Dis 43:762-7. 2011..The clinical applications, indications and timing for hepatic venous pressure gradient measurement, together with measurement principles and costs, are reviewed...
A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosisCarlo Merkel
Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy
Gastroenterology 127:476-84. 2004..Beta-blockers are extensively used to prevent variceal bleeding in patients with large esophageal varices. It is not established if beta-blockers delay the growth of small varices...- Disagreement between acute and chronic haemodynamic effects of nadolol in cirrhosis: a pathophysiological interpretationC Merkel
Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
Aliment Pharmacol Ther 22:433-9. 2005..The acute effects of beta-blockers may be different from chronic; mechanisms underlying this difference are poorly elucidated... - Clinical significance of worsening portal hypertension during long-term medical treatment in patients with cirrhosis who had been classified as early good-responders on haemodynamic criteriaCarlo Merkel
Department of Clinical and Experimental Medicine, University of Padua, Italy
J Hepatol 52:45-53. 2010..However, it is not known whether the effect remains unchanged over the treatment period... - Should we routinely measure portal pressure in patients with cirrhosis, using hepatic venous pressure gradient (HVPG) as guidance for prophylaxis and treatment of bleeding and re-bleeding? Yes!Carlo Merkel
Hepatic Haemodynamics Laboratory and Clinica Medica 5, Department of Clinical and Experimental Medicine, University of Padua, Italy
Eur J Intern Med 22:1-4. 2011..Thus, although not necessarily easy to measure, HVPG provides the clinician with information which is prognostically crucial and otherwise unobtainable... - Portal hypertension and portal hypertensive gastropathy in patients with liver cirrhosis: a haemodynamic studyC Merkel
Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy
Dig Liver Dis 35:269-74. 2003..The relationships between the levels of portal hypertension and the morphologic alterations of gastric mucosa in patients with liver cirrhosis--generally described as portal hypertensive gastropathy--are poorly defined... - The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosisC Merkel
Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
Hepatology 32:930-4. 2000..In conclusion, the assessment of hemodynamic response to drugs in terms of HVPG is the best predictor of efficacy of prophylaxis of variceal bleeding in patients treated with beta-blockers or beta-blockers plus nitrates... - Noninvasive grading of the severity of portal hypertension in cirrhotic patients by echo-color-DopplerM Bolognesi
Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
Ultrasound Med Biol 27:901-7. 2001..066*splenic PI -0.044)*PBF]. In the second group, predicted and observed portal pressure were well correlated (r = 0.71, p = .0003). A good accuracy for the prediction of mild or severe portal hypertension was obtained... - Long-term results of a clinical trial of nadolol with or without isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosisC Merkel
Department of Clinical Medicine, University of Padua, Italy
Hepatology 31:324-9. 2000..Side effects are few, and no deleterious effects on ascites occurrence or on survival occur after long-term use of this combination... - Arterioportal fistulas in patients with liver cirrhosis: usefulness of color Doppler US for screeningM Bolognesi
Department of Clinical and Experimental Medicine, Clinica Medica 5, Policlinico Universitario, Padova, Italy
Radiology 216:738-43. 2000.... - Portal hypertension: state of the artA Gatta
Department of Clinical and Experimental Medicine, University of Padova, Italy
Ital J Gastroenterol Hepatol 31:326-45. 1999..Moreover, technological developments have introduced new tools for diagnosis, such as echo-colour-Doppler, and therapy, like variceal banding and transjugular intrahepatic porto-systemic shunt... - Clinical features and survivial of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric testsP Amodio
Clinica Medica V, Department of Clinical and Experimental Medicine, University of Padova, Italy
Hepatology 29:1662-7. 1999..1-5.3), or altered Choice2 test (hazard ratio = 2.8; CI95% = 1.2-6. 3). Multivariate regression showed that Scan and Choice2 tests had prognostic value on survival, in addition to Child-Pugh classes in the first year of follow-up... - Randomized clinical study of the efficacy of amiloride and potassium canrenoate in nonazotemic cirrhotic patients with ascitesP Angeli
Department of Clinical Medicine, University of Padua, Italy
Hepatology 19:72-9. 1994..abstract truncated at 250 words).. - Role of spleen enlargement in cirrhosis with portal hypertensionM Bolognesi
Department of Clinical and Experimental Medicine, University of Padua, Italy
Dig Liver Dis 34:144-50. 2002..The increase in spleen size is followed by an increase in splenic blood flow, which participates in portal hypertension actively congesting the portal system... 
Haeme oxygenase mediates hyporeactivity to phenylephrine in the mesenteric vessels of cirrhotic rats with ascitesM Bolognesi
Clinica Medica 5, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
Gut 54:1630-6. 2005..The aim of this study was to verify the role of haeme oxygenase in the hyporesponsiveness to phenylephrine of small mesenteric arteries in rats with CCl(4) induced cirrhosis, with and without ascites...- Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patientsP Amodio
Clinical Medicine 5th, University of Padova, Italy
J Hepatol 35:37-45. 2001..We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations... - Nutrition and survival in patients with liver cirrhosisF Alberino
Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
Nutrition 17:445-50. 2001..These data demonstrate that malnutrition is an independent predictor of survival in patients with liver cirrhosis. The inclusion of anthropometric measures in the assessment of these patients might provide better prognostic information... - Switch therapy with ciprofloxacin vs. intravenous ceftazidime in the treatment of spontaneous bacterial peritonitis in patients with cirrhosis: similar efficacy at lower costP Angeli
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
Aliment Pharmacol Ther 23:75-84. 2006..Intravenous administration of a third-generation cephalosporin is optimal antibiotic treatment for spontaneous bacterial peritonitis... - Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver diseaseC Turato
Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
Dig Liver Dis 41:212-6. 2009..A novel SCCA-1 variant (SCCA-PD), presenting a single mutation in the reactive centre (Gly351Ala), has been recently identified (rs3180227)... - New abdominal collaterals at ultrasound: a clue of progression of portal hypertensionA Berzigotti
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Italy
Dig Liver Dis 40:62-7. 2008..Abdominal portal-systemic collaterals may be protective from the formation and growth of oesophageal varices, but available data are inconclusive... - A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosisD Patch
Department of Liver Transplantation and Hepatobiliary Medicine, University Department of Surgery, Royal Free Hospital Hampstead NHS Trust, London, UK
Gastroenterology 123:1013-9. 2002..25). Thirty-two percent of patients on medical therapy had died at 1 year, 22.5% on banding (P = 0.97). CONCLUSIONS: In the prevention of variceal rebleeding, beta-blockers +/- nitrates are as effective as endoscopic banding...