Research Topics
| L MenghiniSummaryAffiliation: University of Chieti Country: Italy Publications
| Collaborators
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Detail Information
Publications
Glaucopines A and B, new cyathane diterpenes from the fruiting bodies of Sarcodon glaucopusMassimo Curini
Dipartimento di Chimica e Tecnologia del Farmaco, Sez. Chimica Organica, , Perugia, Italy
Planta Med 71:194-6. 2005..3 micromol/cm2, 61 % edema reduction)...- Anti-inflammatory and analgesic effects of Spartium junceum L. flower extracts: a preliminary studyLuigi Menghini
Department of Drug Science, University of Chieti, Chieti, Italy
J Med Food 9:386-90. 2006..The data from this preliminary study reveal interesting pharmacological properties of S. junceum L. flowers extract related to the marked analgesic activity and the absence of gastric ulcerogenic activity... - Effect of phytochemical concentrations on biological activities of cranberry extractsL Menghini
Dipartimento di Scienze del Farmaco, Università di Chieti Pescara, Chieti, Italy
J Biol Regul Homeost Agents 25:27-35. 2011..Only in DPPH test the free radical scavenging activity seemed to be directly related to proanthocyanidins content... - A multiherbal formulation influencing immune response in vitroL Menghini
Department of Drug Science, University G D Annunzio, Chieti, Italy
Minerva Med 103:13-21. 2012..Aim of this study was to evaluate the effects of phytocomplexes of Uncaria, Shiitake and Ribes in terms of viability and inflammatory response on immune cell-derived cultures... - Antiproliferative, protective and antioxidant effects of artichoke, dandelion, turmeric and rosemary extracts and their formulationL Menghini
Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Italy
Int J Immunopathol Pharmacol 23:601-10. 2010..The positive results of the cell viability test, together with the protective and antiradical activity confirm the rationale for the use of these ingredients in commercial formulations as a health aid tool in modern phytotherapy... 
Phytochemical investigation on leaf extract of Cordia salicifolia ChamLuigi Menghini
Dipartimento di Scienze del Farmaco, University G D Annunzio, Chieti Scalo, Italy
J Med Food 11:193-4. 2008..53%). The major component of the extract exhibited a very weak activity as an inhibitor of growth of Helicobacter pylori in vitro (minimum inhibitory concentration = 200 microg/mL)...- Chemical composition and inhibitory activity against Helicobacter pylori of the essential oil of Apium nodiflorum (Apiaceae)Luigi Menghini
Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Chieti Scalo, Italy
J Med Food 13:228-30. 2010..62%) were the main components. The antimicrobial activity of the essential oil was assayed in vitro against Helicobacter pylori (strain DSMZ 4867), resulting in a minimum inhibitory concentration value of 12.5 microg/mL... - Antiinflammatory activity of coumarins from Ligusticum lucidum Mill. subsp. cuneifolium (Guss.) Tammaro (Apiaceae)Luigi Menghini
Dipartimento di Scienze del Farmaco, University G d Annunzio of Chieti Pescara, Via dei Vestini 31, 66013 Chieti Scalo, Italy
Phytother Res 24:1697-9. 2010..Each compound (0.3 μmol/cm(2) ) induced a significant oedema reduction and compound 4 exerted an effect similar to that of the equimolar dose of the reference drug indomethacin... - In vitro inhibitory activity of boropinic acid against Helicobacter pyloriFrancesco Epifano
Dipartimento di Scienze del Farmaco, Via dei Vestini 31, 66013 Chieti Scalo CH, Italy
Bioorg Med Chem Lett 16:5523-5. 2006..Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 microg/mL... - Antiinflammatory effects in THP-1 cells treated with verbascosideLorenza Speranza
Department of Biomorphology, University G D Annunzio, Chieti, Italy
Phytother Res 24:1398-404. 2010..Based on these results it is hypothesized that verbascoside has antiinflammatory properties since it reduces the production of superoxide radicals and consequently reduces the activity of iNOS... - Preliminary evaluation on anti-inflammatory and analgesic effects of Sideritis syriaca L. herba extractsLuigi Menghini
Department of Drug Science, University of Chieti, Chieti, Italy
J Med Food 8:227-31. 2005..syriaca L. herba extracts related to the marked analgesic activity and the absence of gastric ulcerogenic activity. The same is for anti-inflammatory activity, but in this case it seems to be related only to the apolar fraction... - Natural coumarins as a novel class of neuroprotective agentsFrancesco Epifano
Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Chieti Scalo, Italy
Mini Rev Med Chem 9:1262-71. 2009..The aim of this manuscript is to review what has been reported so far in the literature about coumarins as a novel class of pharmacologically active compounds in chemoprevention and/or therapy of these diseases... - Chemistry and pharmacology of oxyprenylated secondary plant metabolitesFrancesco Epifano
Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Chieti Scalo, Italy
Phytochemistry 68:939-53. 2007..The aim of this review is to examine in detail the different types of oxyprenylated natural compounds from a phytochemical and pharmacological point of view... - Comparison of three different extraction methods and HPLC determination of the anthraquinones aloe-emodine, emodine, rheine, chrysophanol and physcione in the bark of Rhamnus alpinus L. (Rhamnaceae)S Genovese
Dipartimento di Scienze del Farmaco, Università degli Studi G d Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti CH, Italy
Phytochem Anal 21:261-7. 2010..Thus, using simple, reliable and accurate analytical methods for the determination of anthraquinones in R. alpinus extracts allows comparative study of different methods of extraction... - Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitroLuigi Brunetti
Department of Drug Sciences, G. D'Annunzio University, School of Pharmacy, Chieti, Italy
Planta Med 72:1296-9. 2006..This suggests that the oxygen radical scavenging properties of the Ginkgo biloba extract are fully effective in young, as well as in old rats, showing a greater inhibition of isoprostane production in the latter... - Rhamnus alpinus leaf extract suppresses lipopolysaccharide-induced, monocyte-derived macrophage chemokine secretionAnnalisa Chiavaroli
Dipartimento di Science del Farmaco, Via dei Vestini 31, 66013 Chieti Scalo, Chieti, Italy
Inflammation 31:313-8. 2008..This may impede the progression and aggravation of inflammation given that the migration of immune cells plays an important role in the outcome of periodontitis... - Antioxidant effects of garlic in young and aged rat brain in vitroLuigi Brunetti
Department of Drug Sciences, School of Pharmacy, G D Annunzio University, Chieti, Italy
J Med Food 12:1166-9. 2009..In conclusion, garlic supplementation could be effective in preventing brain oxidative damage in young animals, whereas the aging brain seems to be resistant to the antioxidant effects of garlic, in vitro... - Fatty acids profile and antiinflammatory activity of Nonea setosa R. et SMassimo Curini
Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Perugia, Italy
Phytother Res 20:422-3. 2006..GC-MS analysis of the most active fraction revealed the presence of high amounts of polyunsaturated fatty acids... - 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid: a novel promising cancer chemopreventive agentMassimo Curini
Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Via del Liceo, Perugia, Italy
Anticancer Agents Med Chem 6:571-7. 2006..The aim of this review is to examine in detail the properties of the title compound so far reported in the literature from a chemical and pharmacological point of view...