Tommaso Mello

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. doi request reprint Alcohol induced hepatic fibrosis: role of acetaldehyde
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Mol Aspects Med 29:17-21. 2008
  2. doi request reprint FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS
    Elena Maneschi
    Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy
    J Endocrinol 218:215-31. 2013
  3. ncbi request reprint Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells
    Elisabetta Ceni
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Gastroenterology 131:1235-52. 2006
  4. doi request reprint Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo
    Krista Rombouts
    Department of Internal Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    Cancer Lett 333:244-52. 2013
  5. doi request reprint MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells
    Krista Rombouts
    Department of Internal Medicine, University of Florence, Italy
    Am J Physiol Cell Physiol 303:C357-67. 2012
  6. doi request reprint Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma
    Alessandra Gentilini
    Department of Internal Medicine, Center for Research, High Education and Transfer DENOThe, University of Florence, Italy, Largo Brambilla 3, 50134 Florence, Italy
    J Hepatol 57:813-20. 2012
  7. doi request reprint Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: role of A2A adenosine receptors
    Giovanna Maraula
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Neuropharmacology 67:511-20. 2013
  8. pmc The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus
    Giovanna Maraula
    Dept of Neuroscience, Psychology, Drug Research and Child Health, NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, Florence, Italy
    PLoS ONE 9:e115273. 2014
  9. pmc Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells
    Elisabetta Ceni
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgani 85, 50134 Firenze, Italy
    World J Gastroenterol 11:1122-30. 2005
  10. ncbi request reprint EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility
    Matteo Parri
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
    J Biol Chem 282:19619-28. 2007

Collaborators

Detail Information

Publications28

  1. doi request reprint Alcohol induced hepatic fibrosis: role of acetaldehyde
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Mol Aspects Med 29:17-21. 2008
    ..S., 1997. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta 257, 59-84]. This review will focus on the molecular mechanisms by which acetaldehyde promote liver fibrosis...
  2. doi request reprint FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS
    Elena Maneschi
    Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy
    J Endocrinol 218:215-31. 2013
    ..This could reflect the ability of OCA to restore insulin sensitivity in AT unable to finalize its storage function, counteracting MetS-induced metabolic alterations and pathological AT deposition...
  3. ncbi request reprint Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells
    Elisabetta Ceni
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Gastroenterology 131:1235-52. 2006
    ..AcCHO stimulates synthesis of fibrillar collagens in hepatic stellate cells, but the molecular events directly involved in the activation of collagen genes are debatable...
  4. doi request reprint Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo
    Krista Rombouts
    Department of Internal Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    Cancer Lett 333:244-52. 2013
    ..In conclusion, MARCKS plays an articulated role in the progression of colorectal cancer and might represent a suitable target to interfere and overcome the invasive behaviour of colon carcinoma cells at primary and distant sites...
  5. doi request reprint MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells
    Krista Rombouts
    Department of Internal Medicine, University of Florence, Italy
    Am J Physiol Cell Physiol 303:C357-67. 2012
    ..These findings implicate that MARCKS, an important PKC substrate, is essential for proper cytokinesis and that MARCKS and its partner actin are key mitotic regulators during cell cycle in hHSC...
  6. doi request reprint Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma
    Alessandra Gentilini
    Department of Internal Medicine, Center for Research, High Education and Transfer DENOThe, University of Florence, Italy, Largo Brambilla 3, 50134 Florence, Italy
    J Hepatol 57:813-20. 2012
    ..The aim of the present study was to characterize the interaction between CCA cells and human hepatic stellate cells (hHSC) focusing on the role of SDF-1...
  7. doi request reprint Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: role of A2A adenosine receptors
    Giovanna Maraula
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Neuropharmacology 67:511-20. 2013
    ..The adenosine A(2A) antagonist ZM241385 protects from synaptic failure and from decreased proliferation of immature neuronal cells at a precocious time after OGD...
  8. pmc The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus
    Giovanna Maraula
    Dept of Neuroscience, Psychology, Drug Research and Child Health, NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, Florence, Italy
    PLoS ONE 9:e115273. 2014
    ..At later stages after the insult, P2Y1 receptors might play an additional and different role in promoting cell proliferation and maturation in the DG. ..
  9. pmc Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells
    Elisabetta Ceni
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgani 85, 50134 Firenze, Italy
    World J Gastroenterol 11:1122-30. 2005
    ..In this study, we analyzed the mechanism by which TZD inhibit growth of human pancreatic carcinoma cell lines in order to evaluate the potential therapeutic use of these drugs in pancreatic adenocarcinoma...
  10. ncbi request reprint EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility
    Matteo Parri
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
    J Biol Chem 282:19619-28. 2007
    ....
  11. doi request reprint Molecular mechanisms underlying the pro-inflammatory synergistic effect of tumor necrosis factor alpha and interferon gamma in human microvascular endothelium
    Adriana Lombardi
    Department of Clinical Physiopathology, DENOthe Center of Excellence for Research, Transfer and High Education, University of Florence, Viale Pieraccini 6, I 50139 Florence, Italy
    Eur J Cell Biol 88:731-42. 2009
    ..A further mechanism of synergism involving the reciprocal upregulation of TNFalpha-RII and of IFNgamma-R, in response to IFNgamma and TNFalpha, respectively, was revealed by flow cytometry and quantitative real time RT-PCR analysis...
  12. doi request reprint Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus-transgenic mice by peroxisome proliferator-activated receptor gamma-independent regulation of nucleophosmin
    Andrea Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Hepatology 52:493-505. 2010
    ..TZD inhibited NPM expression at protein and messenger RNA levels and decreased NPM promoter activity. TZD inhibition of NPM was associated with the induction of p53 phosphorylation and p21 expression...
  13. doi request reprint COUP-TFII in pancreatic adenocarcinoma: clinical implication for patient survival and tumor progression
    Simone Polvani
    Department of Experimental and Clinical Biomedical Sciences, University of Florence, Firenze, Italy
    Int J Cancer 134:1648-58. 2014
    ..Our results suggest that COUP-TFII might be an important regulator of the behavior of pancreatic adenocarcinoma, thus representing a possible new target for pancreatic cancer therapy. ..
  14. ncbi request reprint The potential of antidiabetic thiazolidinediones for anticancer therapy
    Andrea Galli
    University of Florence, Gastroenterology Unit, Department of Clinical Pathophysiology, Viale Morgani 85, 50134 Firenze, Florence, Italy
    Expert Opin Investig Drugs 15:1039-49. 2006
    ..This review summarises the molecular mechanisms of the antineoplastic actions of TZDs and the relevance of these findings in human pathology and therapy...
  15. pmc Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells
    Leonardo Guasti
    Department of Experimental Pathology and Oncology, University of Florence, Viale G B Morgagni 50, 50134 Florence, Italy
    Mol Cell Biol 28:5043-60. 2008
    ..The silencing of USO-containing hERG1 isoforms induces a higher I(hERG1) density in tumors, an effect that apparently regulates neurite outgrowth in neuroblastoma cells and apoptosis in leukemia cells...
  16. doi request reprint A new mechanism involving ERK contributes to rosiglitazone inhibition of tumor necrosis factor-alpha and interferon-gamma inflammatory effects in human endothelial cells
    Adriana Lombardi
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Arterioscler Thromb Vasc Biol 28:718-24. 2008
    ....
  17. pmc Telomerase activated thymidine analogue pro-drug is a new molecule targeting hepatocellular carcinoma
    Mirko Tarocchi
    Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
    J Hepatol 61:1064-72. 2014
    ..Therefore, we developed a thymidine analogue pro-drug, acycloguanosyl-5'-thymidyltriphosphate (ACV-TP-T), which is specifically activated by telomerase in HCC cells and investigated its anti-tumour efficacy...
  18. ncbi request reprint Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    Andrea Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Gastroenterology 122:1924-40. 2002
    ..The aim of our study was to evaluate whether oral administration of synthetic PPARgamma ligands, thiazolidinediones (TZD), might affect collagen deposition in animal models of liver fibrosis...
  19. pmc Expression of carboxylesterase and lipase genes in rat liver cell-types
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Biochem Biophys Res Commun 374:460-4. 2008
    ....
  20. doi request reprint P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase 1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro
    Chiara Traini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur J Neurosci 33:2203-15. 2011
    ..These results indicate that subtypes of hippocampal P2 purinergic receptors have a harmful effect on neurotransmission in the CA1 hippocampus by participating in AD appearance and activation of ERK1/2...
  21. pmc Pathogenesis of alcoholic liver disease: role of oxidative metabolism
    Elisabetta Ceni
    Elisabetta Ceni, Tommaso Mello, Andrea Galli, Gastroenterology Unit, Department of Experimental and Clinical Biochemical Sciences, University of Florence, 50139 Florence, Italy
    World J Gastroenterol 20:17756-72. 2014
    ....
  22. doi request reprint Differential expression of junctional adhesion molecules in different stages of systemic sclerosis
    Mirko Manetti
    Azienda Ospedaliero Universitaria Careggi AOUC, Excellence Centre for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, Department of Anatomy, Histology, and Forensic Medicine, University of Florence, Florence, Italy
    Arthritis Rheum 65:247-57. 2013
    ..This study was undertaken to investigate the possible role of JAMs in SSc pathogenesis...
  23. pmc Peroxisome proliferator-activated receptor and retinoic x receptor in alcoholic liver disease
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Firenze, Italy
    PPAR Res 2009:748174. 2009
    ..In conclusion, RXR and PPAR play a central role in the onset and perpetuation of the mechanisms underling all steps of the clinical progression in ALD...
  24. doi request reprint MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cells
    Krista Rombouts
    Department of Internal Medicine, University of Florence, Italy
    Exp Cell Res 314:1444-54. 2008
    ..In conclusion, the present study indicates that MARCKS play a major key role in PDGF-BB-induced chemotaxis in activated hHSC...
  25. doi request reprint Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain
    Lorenzo Di Cesare Mannelli
    Department of Neurosciences, Psychology, Drug Research and Child Health NEUROFARBA, Pharmacology and Toxicology Section, University of Florence, Florence, Italy
    J Pain 14:1585-600. 2013
    ..In particular, on day 21, a significant astrocyte increase was measured in the anterior cingulate cortex, somatosensory area 1, neostriatum, ventrolateral periaqueductal gray, and nucleus raphe magnus...
  26. doi request reprint Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements
    Elena Maneschi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini, 6, Florence 50139, Italy
    J Endocrinol 215:347-62. 2012
    ..In conclusion, testosterone dosing in a MetS animal model positively affects VAT functions. This could reflect the ability of testosterone in restoring insulin sensitivity in VAT, thus counteracting metabolic alterations...
  27. pmc Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects
    Irene Paterniti
    Department of Pharmacology, University of Florence, Italy
    J Neuroinflammation 8:31. 2011
    ..We investigated the hypothesis that the main action mechanism of agonists and antagonists is at peripheral or central sites...
  28. ncbi request reprint Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species
    Maria Letizia Taddei
    Department of Biochemical Sciences, University of Florence, Florence, Italy
    Antioxid Redox Signal 9:469-81. 2007
    ....