S Melino

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi Molecular properties of lysozyme-microbubbles: towards the protein and nucleic acid delivery
    Sonia Melino
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Amino Acids 43:885-96. 2012
  2. ncbi A metal-binding site in the RTN1-C protein: new perspectives on the physiological role of a neuronal protein
    Ridvan Nepravishta
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Metallomics 4:480-7. 2012
  3. ncbi Metal-binding and nuclease activity of an antimicrobial peptide analogue of the salivary histatin 5
    Sonia Melino
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    Biochemistry 45:15373-83. 2006
  4. ncbi The N-terminal rhodanese domain from Azotobacter vinelandii has a stable and folded structure independently of the C-terminal domain
    Sonia Melino
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    FEBS Lett 577:403-8. 2004
  5. ncbi Progress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach
    Sonia Melino
    Department of Chemical Science and Technology, University of Rome Tor Vergata, Italy
    FEBS J 274:2986-3002. 2007
  6. ncbi Nucleic acid binding of the RTN1-C C-terminal region: toward the functional role of a reticulon protein
    Sonia Melino
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Rome, Italy
    Biochemistry 48:242-53. 2009
  7. ncbi Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy
    S Melino
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Italy
    Amino Acids 41:103-12. 2011
  8. ncbi The active essential CFNS3d protein complex
    Sonia Melino
    Department of Chemical Science and Technology, University of Rome Tor Vergata, Italy
    FEBS J 273:3650-62. 2006
  9. ncbi Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family
    Gian Marco Contessa
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
    J Biomol NMR 31:185-99. 2005
  10. ncbi Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors
    B Fazi
    Department of Biology, University of Rome Tor Vergata, Rome 133, Italy
    Oncogene 28:3814-24. 2009

Collaborators

  • Meifang Zhou
  • M Piacentini
  • G Rotilio
  • M Bozzi
  • Francesca Mondello
  • Andrea Motta
  • Giuseppe Brancato
  • E Trotta
  • Massimo Castagnola
  • M Fasano
  • Maurizio Paci
  • Ridvan Nepravishta
  • Daniel O Cicero
  • Gian Marco Contessa
  • Maria Orsale
  • Francesca Polizio
  • Alessandro Lentini
  • B Fazi
  • Tiziana Cabras
  • Matteo Pennestri
  • M Paci
  • Mariana Gallo
  • Barbara Fazi
  • M Gallo
  • Raffaele Petruzzelli
  • Vincent Torre
  • Alessandro Desideri
  • Daniel Oscar Cicero
  • Tonino Bucciarelli
  • Bruno Provenzano
  • Alessia Bellomaria
  • Claudio Tabolacci
  • Simone Beninati
  • S De Rubeis
  • C Bagni
  • F Di Sano
  • Maria Patamia
  • Irene Messana
  • Antonella Ragnini-Wilson
  • Elena Caroli Casavola
  • Rosanna Inzitari
  • Federica Di Sano
  • Riccardo Melis
  • G Schettini
  • S Thellung
  • T Florio
  • G Damonte
  • D Paludi
  • D O Cicero
  • A Salis
  • A Aceto
  • K Chiovitti
  • E Millo
  • A Corsaro
  • Fabio Forlani
  • Silvia Pagani
  • Giuseppina Andreotti
  • Andrea Amadei
  • Carmine Di Ilio
  • Paolo Sacchetta
  • Fernanda Amicarelli
  • Nicola Celli
  • Domenico Rotilio

Detail Information

Publications24

  1. ncbi Molecular properties of lysozyme-microbubbles: towards the protein and nucleic acid delivery
    Sonia Melino
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Amino Acids 43:885-96. 2012
    ..These results highlight on the possibility of using LysMBs for delivery of proteins and nucleic acids in prophylactic and therapeutic applications...
  2. ncbi A metal-binding site in the RTN1-C protein: new perspectives on the physiological role of a neuronal protein
    Ridvan Nepravishta
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Metallomics 4:480-7. 2012
    ....
  3. ncbi Metal-binding and nuclease activity of an antimicrobial peptide analogue of the salivary histatin 5
    Sonia Melino
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    Biochemistry 45:15373-83. 2006
    ..The results show a new property of this family of salivary peptides and suggest a novel use of this peptide as a small nuclease and biotechnological tool...
  4. ncbi The N-terminal rhodanese domain from Azotobacter vinelandii has a stable and folded structure independently of the C-terminal domain
    Sonia Melino
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    FEBS Lett 577:403-8. 2004
    ..Its solution structure by NMR, actually under course, will be a valid contribution to understand the role of this domain in the folding process of the sulfurtransferase...
  5. ncbi Progress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach
    Sonia Melino
    Department of Chemical Science and Technology, University of Rome Tor Vergata, Italy
    FEBS J 274:2986-3002. 2007
    ....
  6. ncbi Nucleic acid binding of the RTN1-C C-terminal region: toward the functional role of a reticulon protein
    Sonia Melino
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Rome, Italy
    Biochemistry 48:242-53. 2009
    ....
  7. ncbi Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy
    S Melino
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Italy
    Amino Acids 41:103-12. 2011
    ....
  8. ncbi The active essential CFNS3d protein complex
    Sonia Melino
    Department of Chemical Science and Technology, University of Rome Tor Vergata, Italy
    FEBS J 273:3650-62. 2006
    ....
  9. ncbi Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family
    Gian Marco Contessa
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
    J Biomol NMR 31:185-99. 2005
    ..Excluded regions comprise calcium binding loops and loops connecting the EF-hand motifs...
  10. ncbi Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors
    B Fazi
    Department of Biology, University of Rome Tor Vergata, Rome 133, Italy
    Oncogene 28:3814-24. 2009
    ..These data demonstrate a molecular mechanism by which RTN-1C controls apoptosis and indicate this protein to be a novel potential target for cancer therapy...
  11. ncbi Unfolding and inactivation of monomeric superoxide dismutase from E. coli by SDS
    M Bozzi
    Department of Chemical Science and Technology, Tor Vergata University, Via della Ricerca Scientifica, 00133, Rome, Italy
    Int J Biol Macromol 29:99-105. 2001
    ..The unfolding is reversible and both, the tridimensional structure of the protein and the active site, can be restored upon dialysis. In addition, unfolding occurs without loss of metals in the solution...
  12. ncbi Reticulon RTN1-C(CT) peptide: a potential nuclease and inhibitor of histone deacetylase enzymes
    Ridvan Nepravishta
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Rome, Italy
    Biochemistry 49:252-8. 2010
    ..These results allow to propose the Cu/Ni-RTN1-C(CT) complexes as models for the design of antitumor agents...
  13. ncbi Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation
    M Gallo
    Department of Chemical Science and Technology, University of Rome Tor Vergata, Rome, Italy
    Int J Immunopathol Pharmacol 18:95-112. 2005
    ..We propose that a lower alpha 3-helical propensity leading to a major destabilization of the PrPc molecule initiates the pathogenic process associated with D202N capping mutation...
  14. ncbi Cloning, expression, and preliminary structural characterization of RTN-1C
    Barbara Fazi
    Department of Science and Chemical Technologies, University of Rome Tor Vergata, Italy
    Biochem Biophys Res Commun 342:881-6. 2006
    ..We also produced the isotopically labelled protein and the procedure adopted allowed us to plan future NMR studies to investigate the biochemical behaviour of reticulon-1C and of its peptides spanning out from the membrane...
  15. ncbi Two distinct calcium-calmodulin interactions with N-terminal regions of the olfactory and rod cyclic nucleotide-gated channels characterized by NMR spectroscopy
    Maria Orsale
    Department of Chemical Sciences and Technologies, University of Rome 'Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
    FEBS Lett 548:11-6. 2003
    ....
  16. ncbi Backbone NMR assignment of the 29.6 kDa rhodanese protein from Azotobacter vinelandii
    Mariana Gallo
    Department of Chemical Science and Technology, University of Rome Tor Vergata, Rome, Italy
    J Biomol NMR 36:73. 2006
  17. ncbi Structural basis for the interaction of the myosin light chain Mlc1p with the myosin V Myo2p IQ motifs
    Matteo Pennestri
    Department of Chemical Science and Technology, Universita di Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
    J Biol Chem 282:667-79. 2007
    ..This finding gives us a novel view of how calmodulin and essential light chain, through a differential binding to IQ1 of class V myosin motor, regulate this activity during vegetative growth and cytokinesis...
  18. ncbi Structural rearrangements of the two domains of Azotobacter vinelandii rhodanese upon sulfane sulfur release: essential molecular dynamics, 15N NMR relaxation and deuterium exchange on the uniformly labeled protein
    Daniel Oscar Cicero
    INFM, Sez. B, University of Rome Tor Vergata, Rome, Italy
    Int J Biol Macromol 33:193-201. 2003
    ..On the contrary these results clearly indicate that upon the catalytic mechanism the two domains of the protein behave as a unique fold...
  19. ncbi Post-translational modification of glutamine and lysine residues of HIV-1 aspartyl protease by transglutaminase increases its catalytic activity
    Alessandro Lentini
    Department of Biology, University Tor Vergata, Rome, Italy
    Biochem Biophys Res Commun 393:546-50. 2010
    ..Negligible amount of N(1),N(8)-bis(gamma-glutamyl)SPD were found. The significance of these results is discussed with respect to the activation of the protease by post-translational modification and design of potential inhibitors...
  20. ncbi Azotobacter vinelandii rhodanese: selenium loading and ion interaction studies
    Sonia Melino
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome 'Tor Vergata, Italy
    Eur J Biochem 270:4208-15. 2003
    ..These results indicate that rhodanese-like proteins may function in the delivery of reactive selenium in vivo...
  21. ncbi Surface changes and role of buried water molecules during the sulfane sulfur transfer in rhodanese from Azotobacter vinelandii: a fluorescence quenching and nuclear magnetic relaxation dispersion spectroscopic study
    Mauro Fasano
    Dipartimento di Biologia Strutturale e Funzionale, University of Insubria, via Jean H Dunant 3, 21100 Varese, Italy
    Biochemistry 42:8550-7. 2003
    ..e., to cyanide, transforming it into thiocyanate) or in the role of sulfur insertase for the formation of the Fe(2)S(2) iron-sulfur cluster in sulfur-deprived ferredoxins...
  22. ncbi Pro-oxidant activity of histatin 5 related Cu(II)-model peptide probed by mass spectrometry
    Tiziana Cabras
    Dipartimento di Scienze Applicate ai Biosistemi, Universita di Cagliari, Italy
    Biochem Biophys Res Commun 358:277-84. 2007
    ..The results of the study suggest that the production of reactive oxygen species can be an intrinsic property of histatin 5 connected to its ability to bind metals...
  23. ncbi Assignment of the 1H, 13C and 15N resonances of Mlc1p from Saccharomices cerevisiae
    Sonia Melino
    J Biomol NMR 31:367-8. 2005
  24. ncbi Amino acid sequence of the major form of toad liver glutathione transferase
    Tonino Bucciarelli
    Dipartimento di Scienze Biomediche, , Chieti, Italy
    Int J Biochem Cell Biol 34:1286-90. 2002
    ..On the basis of its structural and immunological properties the toad liver GST, indicated as bbGSTP2-2, could represent the prototype of a subset of the pi family...