G Melino

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. doi request reprint Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor
    Jean Pierre Roperch
    Institut National de la Sante, Recherche Medicale U673 Molecular and Clinical Oncology of Solid Tumors, Universite Pierre et Marie Curie Paris 6, Hopital Saint Antoine, Paris, France
    Cancer Res 68:8231-9. 2008
  2. ncbi request reprint p63 and p73, members of the p53 gene family, transactivate PKCdelta
    Raffaella Ponassi
    Biochemistry Laboratory, IDI IRCCS, c o University of Rome Tor Vergata, 00133 Rome, Italy
    Biochem Pharmacol 72:1417-22. 2006
  3. ncbi request reprint TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, London, UK
    J Neurochem 99:989-99. 2006
  4. ncbi request reprint A cytoplasmic PML mutant inhibits p53 function
    Cristian Bellodi
    MRC Toxicology Unit, Leicester, UK
    Cell Cycle 5:2688-92. 2006
  5. ncbi request reprint TAp63 and DeltaNp63 in cancer and epidermal development
    Eleonora Candi
    University of Rome Tor Vergata, Rome, Italy
    Cell Cycle 6:274-85. 2007
  6. pmc MicroRNA-203 contributes to skin re-epithelialization
    G Viticchiè
    Department of Experimental Medicine and Surgery, University of Tor Vergata, Via Montpellier, 1, Rome 00133, Italy
    Cell Death Dis 3:e435. 2012
  7. pmc Scotin: A new p63 target gene expressed during epidermal differentiation
    Loredana Zocchi
    IDI IRCCS Biochemistry Laboratory, c o University of Tor Vergata, Department of Experimental Medicine, Via Montpellier 1, 00133 Rome, Italy
    Biochem Biophys Res Commun 367:271-6. 2008
  8. ncbi request reprint Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation
    G Melino
    IDI IRCCS, Department of Experimental Medicine, University of Rome Tor Vergata, Italy
    Cancer Res 60:2377-83. 2000
  9. ncbi request reprint p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
    Gerry Melino
    Biochemistry Laboratory, Instituto Dermopatico Dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 279:8076-83. 2004
  10. ncbi request reprint Nitric oxide can inhibit apoptosis or switch it into necrosis
    G Melino
    IDI IRCCS, Department of Experimental Medicine, University of Rome Tor Vergata, Italy
    Cell Mol Life Sci 57:612-22. 2000

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. doi request reprint Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor
    Jean Pierre Roperch
    Institut National de la Sante, Recherche Medicale U673 Molecular and Clinical Oncology of Solid Tumors, Universite Pierre et Marie Curie Paris 6, Hopital Saint Antoine, Paris, France
    Cancer Res 68:8231-9. 2008
    ..Collectively, our data reveal that the transcriptionally active TAp73alpha tumor suppressor is implicated in the apoptosis induced by netrin-1 in a p53-independent and DCC/ubiquitin-proteasome dependent manner...
  2. ncbi request reprint p63 and p73, members of the p53 gene family, transactivate PKCdelta
    Raffaella Ponassi
    Biochemistry Laboratory, IDI IRCCS, c o University of Rome Tor Vergata, 00133 Rome, Italy
    Biochem Pharmacol 72:1417-22. 2006
    ..The results obtained demonstrated that, at least in vitro, the p53 family members tested (TAp63alpha, TAp73alpha, DeltaNp63alpha, but not DeltaNp73alpha) were able to drive transcription from the PKCdelta promoter...
  3. ncbi request reprint TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, London, UK
    J Neurochem 99:989-99. 2006
    ..Collectively, these findings may have ramifications for neurodevelopment, neurodegeneration and oncogenesis...
  4. ncbi request reprint A cytoplasmic PML mutant inhibits p53 function
    Cristian Bellodi
    MRC Toxicology Unit, Leicester, UK
    Cell Cycle 5:2688-92. 2006
    ..Overall our findings shed new light on the role of PML cytoplasmic proteins in the regulation of p53...
  5. ncbi request reprint TAp63 and DeltaNp63 in cancer and epidermal development
    Eleonora Candi
    University of Rome Tor Vergata, Rome, Italy
    Cell Cycle 6:274-85. 2007
    ..The main aim of this review is to critically discuss the data available in the literature and thoroughly analyze the models proposed...
  6. pmc MicroRNA-203 contributes to skin re-epithelialization
    G Viticchiè
    Department of Experimental Medicine and Surgery, University of Tor Vergata, Via Montpellier, 1, Rome 00133, Italy
    Cell Death Dis 3:e435. 2012
    ....
  7. pmc Scotin: A new p63 target gene expressed during epidermal differentiation
    Loredana Zocchi
    IDI IRCCS Biochemistry Laboratory, c o University of Tor Vergata, Department of Experimental Medicine, Via Montpellier 1, 00133 Rome, Italy
    Biochem Biophys Res Commun 367:271-6. 2008
    ..We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction...
  8. ncbi request reprint Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation
    G Melino
    IDI IRCCS, Department of Experimental Medicine, University of Rome Tor Vergata, Italy
    Cancer Res 60:2377-83. 2000
    ..In conclusion, our data demonstrate that NO can modulate cell death at an upstream level, by interfering with the ability of AP-1 to induce CD95L expression...
  9. ncbi request reprint p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
    Gerry Melino
    Biochemistry Laboratory, Instituto Dermopatico Dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 279:8076-83. 2004
    ..Our findings demonstrate that p73 elicits apoptosis via the mitochondrial pathway using PUMA and Bax as mediators...
  10. ncbi request reprint Nitric oxide can inhibit apoptosis or switch it into necrosis
    G Melino
    IDI IRCCS, Department of Experimental Medicine, University of Rome Tor Vergata, Italy
    Cell Mol Life Sci 57:612-22. 2000
    ..In these apoptotic models, NO is therefore unable to solely inhibit cell death, indicating that it may act below the point of no return elicited by CD95-ligation and ceramide stimulation...
  11. ncbi request reprint p73: Friend or foe in tumorigenesis
    Gerry Melino
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Nat Rev Cancer 2:605-15. 2002
  12. ncbi request reprint Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice
    E Candi
    Biochemistry Laboratory, IDI IRCCS, c o University of Rome Tor Vergata, 00133 Rome, Italy
    Cell Death Differ 13:1037-47. 2006
    ..Conversely, TAp63 transcribed the upper layer's genes (Ets-1, K1, transglutaminases, involucrin). Therefore, the two p63 isoforms appear to play distinct cooperative roles in epidermal formation...
  13. ncbi request reprint miR-203 represses 'stemness' by repressing DeltaNp63
    A M Lena
    Biochemistry Laboratory IDI IRCCS and University of Rome Tor Vergata, Department of Experimental Medicine and Biochemical Sciences, Rome, Italy
    Cell Death Differ 15:1187-95. 2008
    ..In addition, we have shown that miR-203 can regulate DeltaNp63 levels upon genotoxic damage in head and neck squamous cell carcinoma cells, thus controlling cell survival...
  14. ncbi request reprint p63 and p73 transactivate differentiation gene promoters in human keratinocytes
    V De Laurenzi
    Biochemistry Laboratory, Tor Vergata University, Rome, 00133, Italy
    Biochem Biophys Res Commun 273:342-6. 2000
    ..p73 gamma, delta, and p63 were able to transactivate the promoters of loricrin and involucrin in both NHEK and HaCat cells. These results suggest the involvement of both p73 and p63 genes in keratinocyte terminal differentiation...
  15. pmc The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
    A Peschiaroli
    IDI IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome 00133, Italy
    Oncogene 28:3157-66. 2009
    ..All together, these results show that the orphan F-box protein FBXO45 regulates the stability of p73, highlighting a conserved pathway evolved from nematode to human by which the p53 members are regulated by an SCF-dependent mechanism...
  16. ncbi request reprint Modulation of glutathione transferase P1-1 activity by retinoic acid in neuroblastoma cells
    S Bernardini
    Department of Internal Medicine, University of Tor Vergata, Rome, Italy
    J Cell Biochem 75:375-81. 1999
    ....
  17. doi request reprint FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription
    A De Cola
    IDI IRCCS Biochemistry Laboratory, c o Department of Experimental Medicine, University of Rome Tor Vergata, Roma, Italy
    Oncogene 31:573-82. 2012
    ..These results indicate that FLASH is an essential, non-redundant regulator of histone transcription and cell cycle during embryogenesis...
  18. doi request reprint FLASH degradation in response to UV-C results in histone locus bodies disruption and cell-cycle arrest
    L Bongiorno-Borbone
    IDI IRCCS Biochemistry Laboratory, c o Department of Experimental Medicine, University of Rome Tor Vergata, Roma, Italy
    Oncogene 29:802-10. 2010
    ..This provides a novel mechanism of S-phase arrest in response to DNA damage that potentially allows DNA repair before cells continue into mitosis, and thus prevents transmission of genomic alterations...
  19. doi request reprint The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity
    M Malatesta
    Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy
    Oncogene 32:4721-6. 2013
    ..In conclusion, our findings add a novel insight into the regulation of p73 by the CDL4A complex, through the inhibition of its transcriptional function. ..
  20. ncbi request reprint Apoptosis in neuroblastomas induced by interferon-gamma involves the CD95/CD95L pathway
    M Annicchiarico-Petruzzelli
    IDI-IRCCS, Biochemistry Lab, University of Rome Tor Vergata, Italy
    Med Pediatr Oncol 36:115-7. 2001
    ....
  21. doi request reprint FXIIIA and TGF-beta over-expression produces normal musculo-skeletal phenotype in TG2-/- mice
    U Tarantino
    Department of Orthopaedics and Traumatology, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy
    Amino Acids 36:679-84. 2009
    ..In vivo other TGs may be involved in promoting chondrocytes and osteoblast differentiation and matrix mineralisation...
  22. pmc Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage
    M V Catani
    Biochemistry Laboratory, IDI-IRCCS, c/o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, 00133 Rome, Italy
    Biochem J 356:77-85. 2001
    ....
  23. pmc The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival
    A Peschiaroli
    IDI IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Oncogene 29:1384-93. 2010
    ..In conclusion, we showed that USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies...
  24. ncbi request reprint Modulation of GST P1-1 activity by polymerization during apoptosis
    S Bernardini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    J Cell Biochem 77:645-53. 2000
    ..Our data seem to suggest that H(2)O(2) and etoposide may partly act through a process of partial inactivation of the GST P1-1, possibly involving the "G" site in the process of dimerization, and thus favoring programmed cell death...
  25. ncbi request reprint Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro
    E Candi
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricerca e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Biol Chem 276:35014-23. 2001
    ..Indeed, TGase 5 co-localize with vimentin and it is able to cross-link vimentin in vitro...
  26. ncbi request reprint The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets
    M Federici
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-'Tor Vergata, 00133 Rome, Italy
    FASEB J 15:22-24. 2001
    ..These findings establish an important role for the insulin signaling in human b-cell survival and suggest that genetic defects in early steps of insulin signaling may contribute to b-cell failure...
  27. ncbi request reprint Inactivation of multiple targets by nitric oxide in CD95-triggered apoptosis
    F Bernassola
    Biochemistry Laboratory, IDI-IRCCS, c/o Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Cell Biochem 82:123-33. 2001
    ..Even though NO affects multiple molecular mechanisms, the relevant target for exerting the cellular effects, may vary among different models...
  28. ncbi request reprint Transglutaminase 5 is acetylated at the N-terminal end
    A Rufini
    Biochemistry Laboratory, IDI IRCCS, University of Rome Tor Vergata, Rome, Italy
    Amino Acids 26:425-30. 2004
    ..Moreover, in situ measurement of TGase activity shows that endogenous TGase 5 is active upon treatment with phorbol acetate, and the enzyme co-localises with vimentin intermediate filaments...
  29. ncbi request reprint Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    J Biol Chem 275:31938-45. 2000
    ..The data presented indicate a protective role of cannabinoid receptors against apoptosis induced by AEA via vanilloid receptors...
  30. ncbi request reprint 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease
    P G Mastroberardino
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Cell Death Differ 9:873-80. 2002
    ..Taken together these findings suggest an important role for tissue transglutaminase in the regulation of neuronal cell death occurring in Huntington's disease...
  31. doi request reprint Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis
    A Orlandi
    Anatomic Pathology, Department of Biopathology, University of Rome Tor Vergata, School of Medicine, Via Montpellier, 00133, Rome, Italy
    Amino Acids 36:755-63. 2009
    ....
  32. pmc Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage
    M Valeria Catani
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Tor Vergata 135, 00133 Rome, Italy
    Biochem J 364:441-7. 2002
    ..These data suggest a potential mechanism accounting for the anti-carcinogenic and anti-cancer activities of vitamin C...
  33. doi request reprint p63 in epithelial development
    E Candi
    Biochemistry Laboratory IDI IRCCS and University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Cell Mol Life Sci 65:3126-33. 2008
    ..In this review, we summarize the current advances that have been made in understanding the role of p63 in epidermal morphogenesis...
  34. pmc Two new p73 splice variants, gamma and delta, with different transcriptional activity
    V De Laurenzi
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata IRCCS, Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Exp Med 188:1763-8. 1998
    ..The relative expression level of each splice variant may modulate p73 transcriptional and growth suppression activities by affecting heterodimer formation...
  35. doi request reprint miR-143 regulates hexokinase 2 expression in cancer cells
    A Peschiaroli
    Institute of Cellular Biology and Neurobiology, CNR, Rome, Italy
    Oncogene 32:797-802. 2013
    ..All these data unveil a new miRNA-dependent mechanism of regulation of hexokinase expression potentially important in the regulation of glucose metabolism of cancer cells...
  36. ncbi request reprint A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus
    A Terrinoni
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    J Invest Dermatol 114:1136-40. 2000
    ..This study is a report of a mosaic mutation in keratin 16 and also the association of a mutation in the V1 domain of a type I keratin associated with a human disease...
  37. pmc MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation
    A M Lena
    University of Tor Vergata, Department of Experimental Medicine and Biochemical Sciences, Via Montpellier 1, Rome 00133, Italy
    Biochem Biophys Res Commun 423:509-14. 2012
    ..Cdk6 and Satb1 protein levels decrease during keratinocytes replicative senescence and their silencing by siRNA is able to induce a G1 block in cell cycle, accompanied by an increase in senescence-associated markers...
  38. pmc Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins
    M D'Eletto
    Department of Biology, University of Rome Tor Vergata, Italy
    Cell Death Differ 19:1228-38. 2012
    ..Taken together, these data indicate that the TG2 transamidating activity has an important role in the assembly of protein aggregates, as well as in the clearance of damaged organelles by macroautophagy...
  39. ncbi request reprint Overexpressed transglutaminase 5 triggers cell death
    B Cadot
    Biochemistry Laboratory, IDI IRCCS, University of Rome Tor Vergata, Rome, Italy
    Amino Acids 26:405-8. 2004
    ..This raises the possibility that transglutaminase 5 is regulated by GTP in a similar fashion to transglutaminase 2...
  40. ncbi request reprint p73 and p63 protein stability: the way to regulate function?
    Carine Maisse
    Department of Experimental Medicine, Biochemistry Laboratory, IDI IRCCS, University of Rome Tor Vergata, Rome, Italy
    Biochem Pharmacol 66:1555-61. 2003
    ..p73 and p63 stability is regulated not only by protein modifications (phosphorylation, acetylation) but also by its degradation in the proteasome. To this end, the interaction with Mdm2, p300/CBP, and SUMO-1 are discussed in details...
  41. ncbi request reprint NMR structure of the p63 SAM domain and dynamical properties of G534V and T537P pathological mutants, identified in the AEC syndrome
    Daniel O Cicero
    Department of Science and Chemical Technologies, University of Rome Tor Vergata, Rome, Italy
    Cell Biochem Biophys 44:475-89. 2006
    ....
  42. pmc Novel transglutaminase 1 mutations in patients affected by lamellar ichthyosis
    A Terrinoni
    IDI IRCCS c o Department of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy
    Cell Death Dis 3:e416. 2012
    ..In conclusion, this study expands the current knowledge on TGM1 mutation spectrum, increasing the characterization of mutations would provide more accurate prenatal genetic counselling for parents at-risk individuals...
  43. pmc miR-24 affects hair follicle morphogenesis targeting Tcf-3
    I Amelio
    1 Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, Leicester, UK 2 Biochemistry Laboratory IDI IRCCS and University of Rome Tor Vergata, Department of Experimental Medicine and Biochemical Sciences, Rome 00133, Italy
    Cell Death Dis 4:e922. 2013
    ..MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis. ..
  44. ncbi request reprint Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant
    A Bellomaria
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Italy
    Cell Cycle 9:3730-9. 2010
    ..Based on our results, we propose an extended PP xY motif for the Itch recognition motif (P-P-P-Y-x(4)-[ST]-[ILV]), which includes these C-terminal residues to the PP xY motif...
  45. ncbi request reprint Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines
    G Melino
    Biochemistry Laboratory, IDI IRCCS, C10 Department of Experimental Medicine, University of Rome, Tor Vergata, Italy
    Cell Growth Differ 7:787-96. 1996
    ..These results provide evidence that complex posttranslational molecular mechanisms participate in the autocrine/paracrine growth control of the IGF-II loop in neuroblastomas involving proteolytic systems...
  46. ncbi request reprint Itch: a HECT-type E3 ligase regulating immunity, skin and cancer
    G Melino
    IDI IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, Rome 00133, Italy
    Cell Death Differ 15:1103-12. 2008
    ..Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice...
  47. ncbi request reprint Regulation of the p73 protein stability and degradation
    Andrew Oberst
    IDI IRCCS Biochemistry Lab, c o Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy
    Biochem Biophys Res Commun 331:707-12. 2005
    ....
  48. pmc The ubiquitin-protein ligase Itch regulates p73 stability
    Mario Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 24:836-48. 2005
    ..In conclusion, we have identified a key mechanism in the control of p73 protein levels both in normal as well as in stress conditions...
  49. ncbi request reprint Molecular dynamics simulation of the C-terminal sterile alpha-motif domain of human p73alpha: evidence of a dynamical relationship between helices 3 and 5
    Mattia Falconi
    INFM and Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Biochem Biophys Res Commun 316:1037-42. 2004
    ..On the basis of these results we suggest that the recognition properties of the SAM domains may be modulated by the conformational state of helix 5...
  50. ncbi request reprint p73, the "assistant" guardian of the genome?
    Gerry Melino
    Biochemistry Laboratory, IDI IRCCS, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    Ann N Y Acad Sci 1010:9-15. 2003
    ..Several pieces of evidence show a significant interaction between these two proteins. Therefore, while p53 can be rightly defined as the guardian of the genome, we could think of p73 as the "assistant" guardian of the genome!..
  51. pmc The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
    Andrew Oberst
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 104:11280-5. 2007
    ....
  52. pmc Gene disruption of tissue transglutaminase
    V De Laurenzi
    IDI IRCCS Biochemistry Lab, Department of Experimental Medicine, University Tor Vergata, Rome, Italy
    Mol Cell Biol 21:148-55. 2001
    ..It is possible that the residual enzymatic activity, due to TGase 1 or redundancy of other still-unidentified TGases, can compensate for the lack of TGase 2...
  53. pmc p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    G Melino
    Medical Research Council, Toxicology Unit, Hodgkin Building, Leicester University, Leicester, UK
    Cell Death Differ 18:1487-99. 2011
    ..This demonstrates an important role for p63 in cancer development and its progression, and the aim of this review is to set this new evidence that links p63 to metastasis within the context of the long conserved other functions of p63...
  54. ncbi request reprint High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
    M Federici
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    Diabetes 50:1290-301. 2001
    ..These data suggest that in human islets, high glucose may modulate the balance of proapoptotic and antiapoptotic Bcl proteins toward apoptosis, thus favoring beta-cell death...
  55. ncbi request reprint p63 is upstream of IKK alpha in epidermal development
    Eleonora Candi
    Biochemistry Laboratory, IDI IRCCS, University of Rome Tor Vergata, 00133 Rome, Italy
    J Cell Sci 119:4617-22. 2006
    ..We also found that DeltaNp63 upregulates IKKalpha indirectly, through GATA-3. Our data are consistent with a role for p63 directly upstream of IKKalpha in epithelial development...
  56. doi request reprint Connexin 26 (GJB2) mutations as a cause of the KID syndrome with hearing loss
    Alessandro Terrinoni
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Biochem Biophys Res Commun 395:25-30. 2010
    ..We discuss the pathogenesis of both the hearing and skin phenotypes...
  57. ncbi request reprint Expression of GATA-3 in epidermis and hair follicle: relationship to p63
    Anissa Chikh
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, 00133 Rome, Italy
    Biochem Biophys Res Commun 361:1-6. 2007
    ..To further study the relationship between GATA-3 and p63 isoforms here we investigated their expression during keratinocyte differentiation, in human epidermis and hair follicle...
  58. ncbi request reprint Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death
    Stefania Gonfloni
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Nat Med 15:1179-85. 2009
    ..Moreover, they suggest a new use for imatinib, aimed at preserving oocytes of the follicle reserve during chemotherapeutic treatments...
  59. ncbi request reprint TAp73alpha binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy
    Patrizia Vernole
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
    Cell Cycle 8:421-9. 2009
    ..Our results suggest a novel molecular mechanism leading to aneuploidy involving interference of TAp73alpha with Bub1 and Bub3 resulting in an altered mitotic checkpoint...
  60. doi request reprint Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulation
    Alessandro Terrinoni
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Biochem Biophys Res Commun 394:909-14. 2010
    ..These results help to explain the pathogenesis of both the hearing and skin phenotypes, since calcium is also a potent regulator of the epidermal differentiation process...
  61. ncbi request reprint Lipoxygenases and their involvement in programmed cell death
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    Cell Death Differ 8:776-84. 2001
    ..Finally, we discuss the role of lipoxygenase activation in apoptosis of animal and plant cells, suggesting a common signal transduction pathway in cell death conserved through evolution of both kingdoms...
  62. doi request reprint DNA methylation silences miR-132 in prostate cancer
    A Formosa
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Oncogene 32:127-34. 2013
    ..The results of this study point to miR-132 as a methylation-silenced miRNA with an antimetastatic role in PCa controlling cellular adhesion...
  63. ncbi request reprint gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors
    M V Catani
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 74:2373-9. 2000
    ..These findings, together with our previous reports, suggest that the neuronal injury observed in HIV-1 infection could be due to direct (or indirect) interactions between the viral protein gp120 and chemokine and/or NMDA receptors...
  64. ncbi request reprint p63 protein is essential for the embryonic development of vibrissae and teeth
    Alessandro Rufini
    Biochemistry Laboratory IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Biochem Biophys Res Commun 340:737-41. 2006
    ..Moreover, p63 expression in tooth seems not to be fully colocalized with nuclear Ki67 expression...
  65. ncbi request reprint Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient
    Francesca Bernassola
    Biochemistry Laboratory, IDI IRCCS, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    FASEB J 16:1371-8. 2002
    ..Collectively, these results identify TGase 2 as a potential candidate gene in type 2 diabetes...
  66. pmc DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2
    Eleonora Candi
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 104:11999-2004. 2007
    ..The action of DeltaNp63 is not due to a direct regulation of TEC differentiation, but it is compatible with maintenance of their "stemness," the thymic abnormalities resulting from epithelial failure due to loss of stem cells...
  67. doi request reprint The HECT family of E3 ubiquitin ligases: multiple players in cancer development
    Francesca Bernassola
    Department of Experimental Medicine and Biochemical Sciences, Biochemistry IDI IRCCS Laboratory, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Cancer Cell 14:10-21. 2008
    ..Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy...
  68. ncbi request reprint p73-alpha is capable of inducing scotin and ER stress
    Alessandro Terrinoni
    Biochemistry Laboratory, IDI IRCCS, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Oncogene 23:3721-5. 2004
    ..This molecular mechanism might contribute to the effector events inducing apoptosis downstream of p73...
  69. doi request reprint Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression
    Anna Maria Lena
    Biochemistry IDI IRCCS Laboratory and Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Biochem Biophys Res Commun 401:568-73. 2010
    ....
  70. ncbi request reprint A glutamine insertion in the 1A alpha helical domain of the keratin 4 gene in a familial case of white sponge nevus
    A Terrinoni
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    J Invest Dermatol 114:388-91. 2000
    ..We report this new K4 gene mutation and describe an amino acid insertion, in the 1A domain, responsible for a keratin disease...
  71. ncbi request reprint 'Tissue' transglutaminase in cell death: a downstream or a multifunctional upstream effector?
    G Melino
    Istituto Dermopatico dell Immacolata IDI IRCCS, Dept Experimental Medicine, University of Rome Tor Vergata, Italy
    FEBS Lett 430:59-63. 1998
    ..In light of these recent discoveries, the role of tTG in the regulation of the crucial balance between survival and death is clearly complex...
  72. ncbi request reprint Expression of transglutaminase 5 in normal and pathologic human epidermis
    Eleonora Candi
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    J Invest Dermatol 119:670-7. 2002
    ..In Darier's disease, transglutaminase 5 expression, as well as transglutaminase 3, is completely missregulated, being overexpressed or totally absent in different areas of the same lesion...
  73. doi request reprint The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages
    Angelo Peschiaroli
    IDI IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Biochem Biophys Res Commun 402:425-30. 2010
    ..All together these results indicate that WWP1 regulates ΔNp63 transcriptional activity, acting thus as a potential regulator of the proliferation and survival of epithelial-derived cells...
  74. ncbi request reprint Characterization of keratinocyte differentiation induced by ascorbic acid: protein kinase C involvement and vitamin C homeostasis
    Isabella Savini
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Invest Dermatol 118:372-9. 2002
    ..Ascorbic acid may be useful to promote epidermal differentiation, avoiding depletion of hydrophilic antioxidant stores...
  75. doi request reprint OTX1 expression in breast cancer is regulated by p53
    A Terrinoni
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Oncogene 30:3096-103. 2011
    ..Wild-type p53 may regulate cellular differentiation by an alternative pathway controlling OTX1 signaling only in breast cancer cells and not in physiological conditions...
  76. ncbi request reprint Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online
    O Porzio
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Hum Mutat 28:1150. 2007
    ..We conclude that reduced TG2 activity can contribute to disorders of glucose metabolism possibly via an impairment of insulin secretion...
  77. ncbi request reprint FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy
    Lucilla Bongiorno-Borbone
    Department of Experimental Medicine, University of Rome Tor Vergata, Roma, Italy
    Cell Cycle 7:2357-67. 2008
    ..Finally, we show that the two organelles completely co-localize during the S phase of the cell cycle...
  78. doi request reprint Inactive and highly active, proteolytically processed transglutaminase-5 in epithelial cells
    Valentina Pietroni
    Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Invest Dermatol 128:2760-6. 2008
    ..Similar to other members of the TG family-TG1, TG3, and factor XIIIa -, TG5 full-length enzyme has very low enzymatic activity, while the 53-kDa proteolytically processed form is highly active...
  79. pmc Transglutaminase 5 is regulated by guanine-adenine nucleotides
    Eleonora Candi
    Department of Experimental Medicine and Biochemical Sciences, Biochemistry LAb IDI IRCCS, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Biochem J 381:313-9. 2004
    ..Taken together, these results indicate that TGases are a complex family of enzymes regulated by calcium, with at least three of them, namely TGase2, TGase3 and TGase5, also being regulated by ATP and GTP...
  80. ncbi request reprint Vitamin C recycling is enhanced in the adaptive response to leptin-induced oxidative stress in keratinocytes
    Isabella Savini
    Dept Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Invest Dermatol 121:786-93. 2003
    ..Our results show that leptin may induce adaptation to oxidative stress in skin, leading to an improved vitamin C homeostasis...
  81. ncbi request reprint The Tat antagonist neomycin B hexa-arginine conjugate inhibits gp-120-induced death of human neuroblastoma cells
    Maria Valeria Catani
    Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 84:1237-45. 2003
    ..The ability of NeoR to cross the blood-brain barrier, as demonstrated in mice by systemic administration of the fluorescein conjugate drug, makes this compound a powerful and attractive therapeutic agent...
  82. ncbi request reprint Biological role of vitamin C in keratinocytes
    Maria Valeria Catani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Nutr Rev 63:81-90. 2005
    ..All of these vitamin C-mediated responses might be important in different cell types, allowing for the maintenance of body homeostasis...
  83. ncbi request reprint Osmotic resistance of high-density erythrocytes in transglutaminase 2-deficient mice
    Francesca Bernassola
    Biochemistry Laboratory, c o Department of Experimental Medicine, University of Rome Tor Vergata, Via Tor Vergata 135, 00133 Rome, Italy
    Biochem Biophys Res Commun 291:1123-7. 2002
    ....
  84. ncbi request reprint The cornified envelope: a model of cell death in the skin
    Eleonora Candi
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    Nat Rev Mol Cell Biol 6:328-40. 2005
    ....
  85. pmc Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
    Rami I Aqeilan
    Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:4401-6. 2004
    ..In addition, we show that cytoplasmic p73 contributes to the proapoptotic activity of Wwox. Our findings reveal a functional cross-talk between p73 and Wwox tumor suppressor protein...
  86. pmc TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
    Richard Tomasini
    The Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 22:2677-91. 2008
    ..Hence, TAp73 isoforms exert tumor-suppressive functions and indicate an emerging role for Trp73 in the maintenance of genomic stability...
  87. ncbi request reprint Roles for p53 and p73 during oligodendrocyte development
    Nathalie Billon
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, London WC1E 6BT, UK
    Development 131:1211-20. 2004
    ..This is the first evidence for a role of p73 in the differentiation of a normal mammalian cell...
  88. ncbi request reprint p73: in silico evidence for a putative third promoter region
    A Emre Sayan
    Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 313:765-70. 2004
    ..Our results suggest the presence of a candidate 2 kbp genomic DNA in the first intron of human TP73 gene, harbouring 2 putative promoter regions, together with a similar region within intron 1 of the mouse gene...
  89. ncbi request reprint Functional regulation of p73 and p63: development and cancer
    Gerry Melino
    Medical Research Council, Toxicology Unit, LE1 9HN, Leicester, UK
    Trends Biochem Sci 28:663-70. 2003
    ....
  90. ncbi request reprint Fog of war: the emerging p53 family
    Frank McKeon
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Cycle 6:229-32. 2007
  91. ncbi request reprint The p53 homology trap
    Richard A Knight
    Deportment of Cystic Fibrosis, National Heart and Lung Institute, Imperial College, London UK
    Cancer Biol Ther 2:63-6. 2003
  92. pmc Ubiquitin-dependent degradation of p73 is inhibited by PML
    Francesca Bernassola
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 199:1545-57. 2004
    ..Our findings demonstrate that PML plays a crucial role in modulating p73 function, thus providing further insights on the molecular network for tumor suppression...
  93. ncbi request reprint E1A activates transcription of p73 and Noxa to induce apoptosis
    Marcella Flinterman
    Head and Neck Oncology Group, Guy s King s and St Thomas s School of Dentistry, King s College London, SE5 9NU, UK
    J Biol Chem 280:5945-59. 2005
    ..This activation is likely to play a key role in the mechanism of p53-independent apoptosis induced by E1A in some cancers and may provide an avenue for future cancer therapies...
  94. pmc PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73
    Eliana Munarriz
    Medical Research Council, Toxicology Unit, Hodgkin Building, Leicester University, Lancaster Road, P O Box 138, Leicester LE1 9HN, United Kingdom
    Mol Cell Biol 24:10593-610. 2004
    ..These data suggest that PIAS-1, acting partly through binding and sumoylation of p73, is an important component of the cell cycle machinery...
  95. ncbi request reprint p73 induces apoptosis by different mechanisms
    Saafa Ramadan
    Laboratory of Biochemistry and Molecular Biology, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
    Biochem Biophys Res Commun 331:713-7. 2005
    ..In addition, TAp73 is able to transactivate its own second promoter, thus inducing the expression of the anti-apoptotic DeltaNp73 isoform. Therefore, the balance between TAp73 and DeltaNp73 finely regulates cellular sensitivity to death...
  96. pmc New p63 targets in keratinocytes identified by a genome-wide approach
    M Alessandra Vigano
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita di Milano, Milano, Italy
    EMBO J 25:5105-16. 2006
    ..We discovered several new specific targets whose functional categorization links p63 to cell growth and differentiation...
  97. pmc TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria
    Olav Gressner
    Department of Internal Medicine IV, Hepatology and Gastroenterology, University Hospital, Heidelberg, Germany
    EMBO J 24:2458-71. 2005
    ..Thus, beyond its importance in development and differentiation, we describe an important role for TAp63alpha in the induction of apoptosis and chemosensitivity...
  98. ncbi request reprint Degradation of p63 by Itch
    Gerry Melino
    Cell Cycle 5:1735-9. 2006
  99. ncbi request reprint pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation
    Bruna Pucci
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Oncogene 21:5897-905. 2002
    ..Our data suggest a role for pRb2/p130 in glioblastoma gamma-radiation-induced cell death, indicating that the antitumoral action of pRb2/p130 can regulate both inhibition of cell cycle progression and induction of cell death...
  100. ncbi request reprint Calpain cleavage regulates the protein stability of p73
    Eliana Munarriz
    Medical Research Council, Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 333:954-60. 2005
    ..This suggests that calpains may play a physiological role in the regulation of p73 protein stability...
  101. ncbi request reprint The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63
    Francesca Bernassola
    Department of Pathology, Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oncogene 24:6982-6. 2005
    ..Our findings strengthen the relevance of the cross talk between PML and the p53 family members, imply a new tumour suppressive function of PML and unveil a possible role for PML in epidermal morphogenesis and differentiation...