C Mazzoni

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc Hypothesis: is yeast a clock model to study the onset of humans aging phenotypes?
    Cristina Mazzoni
    Department of Biology and Biotechnology Charles Darwin, University of Rome La Sapienza Rome, Italy Pasteur Institute Cenci Bolognetti Foundation, University of Rome La Sapienza Rome, Italy
    Front Oncol 2:203. 2012
  2. pmc Apple can act as anti-aging on yeast cells
    Vanessa Palermo
    Dipartimento di Biologia e Biotecnologie Charles Darwin, Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza Universita di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
    Oxid Med Cell Longev 2012:491759. 2012
  3. pmc Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1beta in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy
    Lucia Paciello
    Dip to Ingegneria Chimica e Alimentare, Universita di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    Microb Cell Fact 8:70. 2009
  4. doi request reprint mRNA stability and control of cell proliferation
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Biology and Biotechnology Charles Darwin, University of Rome La Sapienza, 00185 Rome, Italy
    Biochem Soc Trans 39:1461-5. 2011
  5. doi request reprint PGK1, the gene encoding the glycolitic enzyme phosphoglycerate kinase, acts as a multicopy suppressor of apoptotic phenotypes in S. cerevisiae
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Yeast 26:31-7. 2009
  6. ncbi request reprint Caspase-dependent apoptosis in yeast
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza Piazzale Aldo Moro 5, Rome, Italy
    Biochim Biophys Acta 1783:1320-7. 2008
  7. ncbi request reprint Characterization of a Kluyveromyces lactis mutant with altered regulation of mitochondrial alcohol dehydrogenases
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, Rome, Italy
    FEMS Yeast Res 6:421-7. 2006
  8. pmc Yeast caspase 1 links messenger RNA stability to apoptosis in yeast
    Cristina Mazzoni
    Department of Cell and Developmental Biology, Pasteur Institute Cenci Bolognetti Foundation, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    EMBO Rep 6:1076-81. 2005
  9. ncbi request reprint HIR1, the co-repressor of histone gene transcription of Saccharomyces cerevisiae, acts as a multicopy suppressor of the apoptotic phenotypes of the LSM4 mRNA degradation mutant
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, Piazzale Aldo Moro 5, Italy
    FEMS Yeast Res 5:1229-35. 2005
  10. ncbi request reprint A Kluyveromyces lactis mutant in the essential gene KlLSM4 shows phenotypic markers of apoptosis
    Cristina Mazzoni
    Department of Cell and Developmental Biology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    FEMS Yeast Res 4:29-35. 2003

Collaborators

Detail Information

Publications22

  1. pmc Hypothesis: is yeast a clock model to study the onset of humans aging phenotypes?
    Cristina Mazzoni
    Department of Biology and Biotechnology Charles Darwin, University of Rome La Sapienza Rome, Italy Pasteur Institute Cenci Bolognetti Foundation, University of Rome La Sapienza Rome, Italy
    Front Oncol 2:203. 2012
    ..We observed that similar signs of aging appear in yeast colonies after about 27 days of growth and increase during aging. In this respect we hypothesize to use yeast as a clock to study the onset of human aging phenotypes...
  2. pmc Apple can act as anti-aging on yeast cells
    Vanessa Palermo
    Dipartimento di Biologia e Biotecnologie Charles Darwin, Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza Universita di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
    Oxid Med Cell Longev 2012:491759. 2012
    ..Our results indicate that all the apple components increase lifespan, with the best result given by the whole fruit, indicating a cooperative role of all apple components...
  3. pmc Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1beta in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy
    Lucia Paciello
    Dip to Ingegneria Chimica e Alimentare, Universita di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    Microb Cell Fact 8:70. 2009
    ....
  4. doi request reprint mRNA stability and control of cell proliferation
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Biology and Biotechnology Charles Darwin, University of Rome La Sapienza, 00185 Rome, Italy
    Biochem Soc Trans 39:1461-5. 2011
    ..Recent papers showed the involvement of proteins deputed to decapping in controlling cell proliferation, virus replication and cell death. In this paper, we will review the newest findings in this field...
  5. doi request reprint PGK1, the gene encoding the glycolitic enzyme phosphoglycerate kinase, acts as a multicopy suppressor of apoptotic phenotypes in S. cerevisiae
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Yeast 26:31-7. 2009
    ..This gene restored normal ageing, oxygen peroxide resistance and nuclear integrity in the mutant. Other phenotypes, such as caffeine sensitivity and glycerol utilization, were also suppressed...
  6. ncbi request reprint Caspase-dependent apoptosis in yeast
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza Piazzale Aldo Moro 5, Rome, Italy
    Biochim Biophys Acta 1783:1320-7. 2008
    ..In this review we will summarize the current knowledge in S. cerevisiae on apoptotic processes, induced by internal and external triggers, which are dependent on the metacaspase gene YCA1...
  7. ncbi request reprint Characterization of a Kluyveromyces lactis mutant with altered regulation of mitochondrial alcohol dehydrogenases
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, Rome, Italy
    FEMS Yeast Res 6:421-7. 2006
    ..Strains carrying the aar900 mutation could represent useful tools to unravel the peculiar regulation of KlADH3 and KlADH4 by ethanol...
  8. pmc Yeast caspase 1 links messenger RNA stability to apoptosis in yeast
    Cristina Mazzoni
    Department of Cell and Developmental Biology, Pasteur Institute Cenci Bolognetti Foundation, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    EMBO Rep 6:1076-81. 2005
    ..In addition, we show that mitochondrial function is necessary for fast death during chronological ageing, as well as in LSM4 mutated and wild-type cells...
  9. ncbi request reprint HIR1, the co-repressor of histone gene transcription of Saccharomyces cerevisiae, acts as a multicopy suppressor of the apoptotic phenotypes of the LSM4 mRNA degradation mutant
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, Piazzale Aldo Moro 5, Italy
    FEMS Yeast Res 5:1229-35. 2005
    ..Transcription analysis revealed that the expression of histone genes was lowered in the mutant over-expressing HIR1, indicating a relationship between the latter gene and apoptosis...
  10. ncbi request reprint A Kluyveromyces lactis mutant in the essential gene KlLSM4 shows phenotypic markers of apoptosis
    Cristina Mazzoni
    Department of Cell and Developmental Biology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    FEMS Yeast Res 4:29-35. 2003
    ..RNA analysis revealed that pre-mRNA splicing was almost normal while mRNA degradation was significantly delayed, pointing to this as the possible step responsible for the observed phenotypes...
  11. pmc The inactivation of KlNOT4, a Kluyveromyces lactis gene encoding a component of the CCR4-NOT complex, reveals new regulatory functions
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, 00185 Rome, Italy
    Genetics 170:1023-32. 2005
    ..They activate transcription of KlACS2 and KlCYC1, but repress KlICL1, ScICL1, ScACS1, and ScCYC1. Altogether, our results indicate that Not4p is a pivotal factor involved in the regulation of carbon metabolism in yeast...
  12. ncbi request reprint Isolation and study of KlLSM4, a Kluyveromyces lactis gene homologous to the essential gene LSM4 of Saccharomyces cerevisiae
    C Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, Piazzale A Moro, 00185 Rome, Italy
    Yeast 18:1249-56. 2001
    ..However, the absence of the carboxy-terminal region resulted in a remarkable loss of cell viability in the stationary phase. The KlLSM4 sequence has been deposited in the EMBL Data library under Accession No. AJ311719...
  13. pmc A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome, Italy
    Mol Biol Cell 14:721-9. 2003
    ..This is the first time that a connection between mRNA stability and apoptosis is reported in yeast, pointing to mRNA decapping as the crucial step responsible of the observed apoptotic phenotypes...
  14. ncbi request reprint Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae
    V Palermo
    Department of Cell and Developmental Biology, Pasteur Institute Cenci Bolognetti Foundation, University of Rome La Sapienza, 5 00185 Rome, Italy
    Folia Microbiol (Praha) 52:479-83. 2007
    ..FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells...
  15. ncbi request reprint Molecular analysis of UAS(E), a cis element containing stress response elements responsible for ethanol induction of the KlADH4 gene of Kluyveromyces lactis
    C Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, Italy
    Res Microbiol 151:19-28. 2000
    ..cerevisiae. Gel retardation experiments showed that STREs in the KlADH4 promoter can bind factor(s) under non-inducing conditions. Moreover, we observed that the RAP1 binding site present in UAS(E) binds KlRap1p...
  16. ncbi request reprint How to bring orphan genes into functional families
    M M Bianchi
    Department of Cell and Developmental Biology, University of Rome La Sapienza, Italy
    Yeast 15:513-26. 1999
    ..In many deletant strains, phenotypes were observed and, for the most promising candidates, tetrad analysis was performed in order to verify co-segregation of the deletion marker with the phenotype...
  17. ncbi request reprint Two genes encoding putative mitochondrial alcohol dehydrogenases are present in the yeast Kluyveromyces lactis
    M Saliola
    Department of Cell and Developmental Biology, University of Rome, La Sapienza Città Universitaria, Italy
    Yeast 7:391-400. 1991
    ..cerevisiae than to the KlADH3 presequence. KlADH3 and KlADH4, in contrast to the ADH3 gene of S. cerevisiae, show a strong bias in the choice of codons...
  18. ncbi request reprint The bromodomain-containing protein Bdf1p acts as a phenotypic and transcriptional multicopy suppressor of YAF9 deletion in yeast
    Michele M Bianchi
    Department of Cell and Developmental Biology Cenci Bolognetti Foundation, University of Rome La Sapienza, Ple Aldo Moro, I 00185 Rome, Italy
    Mol Microbiol 53:953-68. 2004
    ....
  19. ncbi request reprint The C-terminus of the yeast Lsm4p is required for the association to P-bodies
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza Piazzale Aldo Moro 5, 00185 Rome, Italy
    FEBS Lett 581:4836-40. 2007
    ..The number of P-bodies also increases after oxidative stress and is not dependent on the meta-caspase gene YCA1, placing this phenomenon upstream to the onset of apoptosis...
  20. ncbi request reprint A new regulatory element mediates ethanol repression of KlADH3, a Kluyveromyces lactis gene coding for a mitochondrial alcohol dehydrogenase
    Michele Saliola
    Department of Cell and Developmental Biology, University of Rome La Sapienza, Piazzale Aldo Moro, Rome, Italy
    FEMS Yeast Res 7:693-701. 2007
    ..In addition, we showed that the ethanol element was required for in vivo repression of KlAdh3 activity...
  21. ncbi request reprint Recombinant expression of Pleurotus ostreatus laccases in Kluyveromyces lactis and Saccharomyces cerevisiae
    Alessandra Piscitelli
    Dipartimento di Chimica Organica e Biochimica, Universita di Napoli Federico II, Complesso Universitario Monte S Angelo, Via Cinthia, 80126 Naples, Italy
    Appl Microbiol Biotechnol 69:428-39. 2005
    ..The availability of the established recombinant expression system provides better understanding of laccase structure-function relationships and allows the development of new oxidative catalysts through molecular evolution techniques...