G Mazzanti

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. doi request reprint Effects of Cimicifuga racemosa extract on liver morphology and hepatic function indices
    G Mazzanti
    Department of Human Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
    Phytomedicine 15:1021-4. 2008
  2. ncbi request reprint [Pharmacological considerations on herbal medicine use]
    Gabriela Mazzanti
    Dipartimento di Fisiologia Umana e Farmacologia Vittorio Erspamer, Universita degli Studi La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Ann Ist Super Sanita 41:23-6. 2005
  3. doi request reprint Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment
    Gabriela Mazzanti
    Department of Physiology and Pharmacology, Sapienza University of Rome, P le Aldo Moro 5, 00185, Rome, Italy
    J Ethnopharmacol 126:518-24. 2009
  4. doi request reprint Hepatotoxicity from green tea: a review of the literature and two unpublished cases
    Gabriela Mazzanti
    Department of Physiology and Pharmacology, Sapienza, University of Rome, Rome, Italy
    Eur J Clin Pharmacol 65:331-41. 2009
  5. doi request reprint Inhibitory activity of Melissa officinalis L. extract on Herpes simplex virus type 2 replication
    G Mazzanti
    Department of Human Physiology and Pharmacology, Sapienza University, Rome, Italy
    Nat Prod Res 22:1433-40. 2008
  6. doi request reprint Purity control of some Chinese crude herbal drugs marketed in Italy
    G Mazzanti
    Department of Human Physiology and Pharmacology, University La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Food Chem Toxicol 46:3043-7. 2008
  7. ncbi request reprint New beta-adrenergic agonists used illicitly as growth promoters in animal breeding: chemical and pharmacodynamic studies
    Gabriela Mazzanti
    Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, University of Roma La Sapienza, P zale Aldo Moro, Italy
    Toxicology 187:91-9. 2003
  8. doi request reprint Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract
    A Di Sotto
    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy
    J Ethnopharmacol 127:731-6. 2010
  9. doi request reprint Cassia angustifolia extract is not hepatotoxic in an in vitro and in vivo study
    A Vitalone
    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy annabella vitalone uniroma1 it
    Pharmacology 88:252-9. 2011
  10. ncbi request reprint Antimicrobial activity of Epilobium spp. extracts
    L Battinelli
    Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
    Farmaco 56:345-8. 2001

Collaborators

Detail Information

Publications33

  1. doi request reprint Effects of Cimicifuga racemosa extract on liver morphology and hepatic function indices
    G Mazzanti
    Department of Human Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
    Phytomedicine 15:1021-4. 2008
    ..From laboratory and clinical studies, black cohosh seems to have a relatively good safety profile, even if a number of case reports of hepatotoxicity were a matter of recent concern...
  2. ncbi request reprint [Pharmacological considerations on herbal medicine use]
    Gabriela Mazzanti
    Dipartimento di Fisiologia Umana e Farmacologia Vittorio Erspamer, Universita degli Studi La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Ann Ist Super Sanita 41:23-6. 2005
    ..Most of the herbal products at present classified as herbal supplements fall into the second and third group: it is apparent that they cannot be considered herbal supplements...
  3. doi request reprint Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment
    Gabriela Mazzanti
    Department of Physiology and Pharmacology, Sapienza University of Rome, P le Aldo Moro 5, 00185, Rome, Italy
    J Ethnopharmacol 126:518-24. 2009
    ..In this work we evaluated the effects on liver function of a C. majus extract, obtained from the herbal material responsible for one case of hepatotoxicity...
  4. doi request reprint Hepatotoxicity from green tea: a review of the literature and two unpublished cases
    Gabriela Mazzanti
    Department of Physiology and Pharmacology, Sapienza, University of Rome, Rome, Italy
    Eur J Clin Pharmacol 65:331-41. 2009
    ..To review the current literature on suspected green tea-related hepatic reactions and to describe two new cases reported within the framework of the Italian surveillance system of natural health products...
  5. doi request reprint Inhibitory activity of Melissa officinalis L. extract on Herpes simplex virus type 2 replication
    G Mazzanti
    Department of Human Physiology and Pharmacology, Sapienza University, Rome, Italy
    Nat Prod Res 22:1433-40. 2008
    ..1% w/w). Our experiments support the use of lemon balm for treating Herpes simplex lesions and encourage clinical trials on this medicinal plant...
  6. doi request reprint Purity control of some Chinese crude herbal drugs marketed in Italy
    G Mazzanti
    Department of Human Physiology and Pharmacology, University La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Food Chem Toxicol 46:3043-7. 2008
    ..Our results, even if obtained from a small number of herbal drugs, show some purity issues and underline the importance of the quality control, particularly for this kind of products whose therapeutic value is not always demonstrated...
  7. ncbi request reprint New beta-adrenergic agonists used illicitly as growth promoters in animal breeding: chemical and pharmacodynamic studies
    Gabriela Mazzanti
    Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, University of Roma La Sapienza, P zale Aldo Moro, Italy
    Toxicology 187:91-9. 2003
    ..4 nM for compound A, 2.8 nM for G4). These pharmacodynamic properties, and stronger lipophilic properties shown by the two compounds may result in increased cardiovascular risk for consumers of illicitly treated animals...
  8. doi request reprint Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract
    A Di Sotto
    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy
    J Ethnopharmacol 127:731-6. 2010
    ..The results obtained in present work support the traditional use and the properties ascribed to Sisymbrium officinale...
  9. doi request reprint Cassia angustifolia extract is not hepatotoxic in an in vitro and in vivo study
    A Vitalone
    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy annabella vitalone uniroma1 it
    Pharmacology 88:252-9. 2011
    ..Nevertheless people use its preparations as self-medication, often for long periods, to treat chronic constipation thus exposing themselves to adverse reactions. Most reactions were associated with hepatotoxicity...
  10. ncbi request reprint Antimicrobial activity of Epilobium spp. extracts
    L Battinelli
    Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
    Farmaco 56:345-8. 2001
    ..The extracts were devoid of toxicity on Artemia salina within the range of antimicrobial concentrations, suggesting that the action is selective on microorganisms...
  11. ncbi request reprint Antimicrobial investigation of semipurified fractions of Ginkgo biloba leaves
    G Mazzanti
    Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, Universita di Roma La Sapienza, P le Aldo Moro 5, 00185, Rome, Italy
    J Ethnopharmacol 71:83-8. 2000
    ..biloba leaves...
  12. ncbi request reprint Isolation of praeruptorins A and B from Peucedanum praeruptorum Dunn. and their general pharmacological evaluation in comparison with extracts of the drug
    M Lu
    Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
    Farmaco 56:417-20. 2001
    ..2, 121.2 and 34.5 microg/ml, respectively. AcOEt and praeruptorin A showed antimicrobial activity on Streptococcus agalactiae; their MIC values were 250 and 100 microg/ml, respectively...
  13. doi request reprint Antimutagenic activity of a secoisopimarane diterpenoid from Salvia cinnabarina M. Martens et Galeotti in the bacterial reverse mutation assay
    A Di Sotto
    Department of Physiology and Pharmacology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Food Chem Toxicol 47:2092-6. 2009
    ....
  14. ncbi request reprint Anti-proliferative effect on a prostatic epithelial cell line (PZ-HPV-7) by Epilobium angustifolium L
    A Vitalone
    Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
    Farmaco 56:483-9. 2001
    ..angustifolium extract against BPH seems to be justified. However, further experimental studies are needed to determine the biochemical mechanism of the action and the clinical value of the E. angustifolium extract...
  15. ncbi request reprint In vitro activity of tea tree oil against Candida albicans mycelial conversion and other pathogenic fungi
    L Laino
    Institute of Microbiology, University La Sapienza, Rome, Italy
    J Chemother 13:377-83. 2001
    ..These results, if considered along with the lipophilic nature of the oil which enables it to penetrate the skin, suggest it may be suitable for topical therapeutic use in the treatment of fungal mucosal and cutaneous infections...
  16. ncbi request reprint In vitro antifungal and anti-elastase activity of some aliphatic aldehydes from Olea europaea L. fruit
    L Battinelli
    Department of Human Physiology and Pharmacology, University La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
    Phytomedicine 13:558-63. 2006
    ....
  17. ncbi request reprint The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay
    M G Evandri
    Department of Human Physiology and Pharmacology, University La Sapienza, 00185 Rome, Italy
    Food Chem Toxicol 43:1381-7. 2005
    ..80 mg/plate) also showed moderate antimutagenicity against the TA98 strain exposed to the direct mutagen 1-nitropyrene. Its antimutagenic property makes lavender oil a promising candidate for new applications in human healthcare...
  18. ncbi request reprint Atractylis gummifera L. poisoning: an ethnopharmacological review
    C Daniele
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
    J Ethnopharmacol 97:175-81. 2005
    ..New therapeutic approaches could come from immunotherapy research: some studies have already tried to produce polyclonal Fab fragments against the toxic components of Atractylis gummifera...
  19. doi request reprint Suspected adverse reactions associated with herbal products used for weight loss: a case series reported to the Italian National Institute of Health
    Annabella Vitalone
    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy
    Eur J Clin Pharmacol 67:215-24. 2011
    ..The aim of this study was to describe suspected adverse reactions (ARs) associated with herbal products used for weight control in Italy...
  20. ncbi request reprint A pharmacodynamic study on clenbuterol-induced toxicity: beta1- and beta2-adrenoceptors involvement in guinea-pig tachycardia in an in vitro model
    Gabriela Mazzanti
    Department of Human Physiology and Pharmacology, University La Sapienza, P le Aldo Moro, 5 00185 Rome, Italy
    Food Chem Toxicol 45:1694-9. 2007
    ..Further experiments are necessary to understand which beta-adrenergic antagonists are of effectiveness to counteract cardiovascular effects in case of intoxication following clenbuterol, or other beta-adrenergic stimulants...
  21. ncbi request reprint Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells
    Lucia Battinelli
    Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
    Planta Med 69:910-3. 2003
    ..In general, the results obtained point out a similar anti-HIV activity of limonin and nomilin indicating that this activity is not drastically influenced by the structural difference between the two compounds...
  22. doi request reprint Surveillance of suspected adverse reactions to natural health products in Italy
    Francesca Menniti-Ippolito
    National Centre for Epidemiology, National Institute of Health, Rome, Italy
    Pharmacoepidemiol Drug Saf 17:626-35. 2008
    ..The system has been set up by the Italian National Institute of Health...
  23. ncbi request reprint In vitro anti-HIV activity of oleanolic acid on infected human mononuclear cells
    Fabio Mengoni
    Department of Infectious and Tropical Diseases, University La Sapienza, Rome, Italy
    Planta Med 68:111-4. 2002
    ..7 microM, 24.6 microM and 57.4 microM for in vitro infected PBMC, naturally infected PBMC and M/M, respectively). As regards the mechanism of action, oleanolic acid inhibits in vitro the HIV-1 protease activity...
  24. ncbi request reprint Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters
    Maria Teresa Gatto
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, P le Aldo Moro 5, 00185, Rome, Italy
    Bioorg Med Chem 10:269-72. 2002
    ..In particular, 3-O-acyl-quercetines, being more active (IC(16)=10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae, and deserve to be studied further...
  25. ncbi request reprint Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparations
    Mei Lu
    Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
    Planta Med 68:213-6. 2002
    ....
  26. ncbi request reprint Antifungal activity of Lavandula angustifolia essential oil against Candida albicans yeast and mycelial form
    F D D'Auria
    Department of Public Health, University La Sapienza, Rome, Italy
    Med Mycol 43:391-6. 2005
    ..At lower concentrations, it inhibits germ tube formation and hyphal elongation, indicating that it is effective against C. albicans dimorphism and may thus reduce fungal progression and the spread of infection in host tissues...
  27. ncbi request reprint Adverse-event profile of Crataegus spp.: a systematic review
    Claudia Daniele
    Department of Pharmacology of Natural Substance and General Physiology, University of Rome, La Sapienza, Rome, Italy
    Drug Saf 29:523-35. 2006
    ..Moreover, the unsupervised use of this drug can be associated with problems, especially if given with concomitant medications...
  28. ncbi request reprint Surveillance of suspected adverse reactions to natural health products: the case of propolis
    Francesca Menniti-Ippolito
    National Centre for Epidemiology, National Institute of Health, Rome, Italy
    Drug Saf 31:419-23. 2008
    ..The public and healthcare practitioners should be aware of the risk of allergic reactions to products derived from bees and a warning should be added to the packaging of these products...
  29. ncbi request reprint [Pilot study for the surveillance of adverse reactions to herbal preparations and dietary supplements]
    Francesca Menniti-Ippolito
    Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann Ist Super Sanita 41:39-42. 2005
    ..After this experience we strongly believe that a system to assess the safety of herbal preparations is needed...
  30. ncbi request reprint Phenolic compounds from Baseonema acuminatum leaves: isolation and antimicrobial activity
    Marinella De Leo
    Dipartimento di Chimica Bioorganica e Biofarmacia, Universita di Pisa, Pisa, Italy
    Planta Med 70:841-6. 2004
    ..albicans with MICs of 12.5 microg/mL and 25 microg/mL. Compounds 1, 6, 7, and 8 inhibited only one strain of C albicans at the maximum concentration used. None of the phenolic compounds tested was active against the bacteria studied...
  31. ncbi request reprint Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent
    Antonio Bianchi
    Traditional Medicine Department, Centro di Orientamento Educativo, Barzio, Italy
    Ann Pharmacother 38:1222-5. 2004
    ..To report a case of rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent...
  32. ncbi request reprint New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum
    Gabriela Mazzanti
    Ann Intern Med 140:W30. 2004
  33. ncbi request reprint Antimicrobial diterpenes from the seeds of Cephalotaxus harringtonia var. drupacea
    Matteo Politi
    Planta Med 69:468-70. 2003
    ..Ferruginol and 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one showed antimicrobial activity against Gram-positive bacteria. None of the six diterpenes was active against the Gram-negative organisms and yeasts tested...