Research Topics
| G MazzantiSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Detail Information
Publications
Effects of Cimicifuga racemosa extract on liver morphology and hepatic function indicesG Mazzanti
Department of Human Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
Phytomedicine 15:1021-4. 2008..From laboratory and clinical studies, black cohosh seems to have a relatively good safety profile, even if a number of case reports of hepatotoxicity were a matter of recent concern...
[Pharmacological considerations on herbal medicine use]Gabriela Mazzanti
Dipartimento di Fisiologia Umana e Farmacologia Vittorio Erspamer, Universita degli Studi La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
Ann Ist Super Sanita 41:23-6. 2005..Most of the herbal products at present classified as herbal supplements fall into the second and third group: it is apparent that they cannot be considered herbal supplements...- Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experimentGabriela Mazzanti
Department of Physiology and Pharmacology, Sapienza University of Rome, P le Aldo Moro 5, 00185, Rome, Italy
J Ethnopharmacol 126:518-24. 2009..In this work we evaluated the effects on liver function of a C. majus extract, obtained from the herbal material responsible for one case of hepatotoxicity... - Hepatotoxicity from green tea: a review of the literature and two unpublished casesGabriela Mazzanti
Department of Physiology and Pharmacology, Sapienza, University of Rome, Rome, Italy
Eur J Clin Pharmacol 65:331-41. 2009..To review the current literature on suspected green tea-related hepatic reactions and to describe two new cases reported within the framework of the Italian surveillance system of natural health products... - Inhibitory activity of Melissa officinalis L. extract on Herpes simplex virus type 2 replicationG Mazzanti
Department of Human Physiology and Pharmacology, Sapienza University, Rome, Italy
Nat Prod Res 22:1433-40. 2008..1% w/w). Our experiments support the use of lemon balm for treating Herpes simplex lesions and encourage clinical trials on this medicinal plant... - Purity control of some Chinese crude herbal drugs marketed in ItalyG Mazzanti
Department of Human Physiology and Pharmacology, University La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
Food Chem Toxicol 46:3043-7. 2008..Our results, even if obtained from a small number of herbal drugs, show some purity issues and underline the importance of the quality control, particularly for this kind of products whose therapeutic value is not always demonstrated... - New beta-adrenergic agonists used illicitly as growth promoters in animal breeding: chemical and pharmacodynamic studiesGabriela Mazzanti
Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, University of Roma La Sapienza, P zale Aldo Moro, Italy
Toxicology 187:91-9. 2003..4 nM for compound A, 2.8 nM for G4). These pharmacodynamic properties, and stronger lipophilic properties shown by the two compounds may result in increased cardiovascular risk for consumers of illicitly treated animals... - Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extractA Di Sotto
Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy
J Ethnopharmacol 127:731-6. 2010..The results obtained in present work support the traditional use and the properties ascribed to Sisymbrium officinale... - Cassia angustifolia extract is not hepatotoxic in an in vitro and in vivo studyA Vitalone
Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy annabella vitalone uniroma1 it
Pharmacology 88:252-9. 2011..Nevertheless people use its preparations as self-medication, often for long periods, to treat chronic constipation thus exposing themselves to adverse reactions. Most reactions were associated with hepatotoxicity... - Antimicrobial activity of Epilobium spp. extractsL Battinelli
Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
Farmaco 56:345-8. 2001..The extracts were devoid of toxicity on Artemia salina within the range of antimicrobial concentrations, suggesting that the action is selective on microorganisms... - Antimicrobial investigation of semipurified fractions of Ginkgo biloba leavesG Mazzanti
Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, Universita di Roma La Sapienza, P le Aldo Moro 5, 00185, Rome, Italy
J Ethnopharmacol 71:83-8. 2000..biloba leaves... - Isolation of praeruptorins A and B from Peucedanum praeruptorum Dunn. and their general pharmacological evaluation in comparison with extracts of the drugM Lu
Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
Farmaco 56:417-20. 2001..2, 121.2 and 34.5 microg/ml, respectively. AcOEt and praeruptorin A showed antimicrobial activity on Streptococcus agalactiae; their MIC values were 250 and 100 microg/ml, respectively... - Antimutagenic activity of a secoisopimarane diterpenoid from Salvia cinnabarina M. Martens et Galeotti in the bacterial reverse mutation assayA Di Sotto
Department of Physiology and Pharmacology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Food Chem Toxicol 47:2092-6. 2009.... - Anti-proliferative effect on a prostatic epithelial cell line (PZ-HPV-7) by Epilobium angustifolium LA Vitalone
Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
Farmaco 56:483-9. 2001..angustifolium extract against BPH seems to be justified. However, further experimental studies are needed to determine the biochemical mechanism of the action and the clinical value of the E. angustifolium extract... - In vitro activity of tea tree oil against Candida albicans mycelial conversion and other pathogenic fungiL Laino
Institute of Microbiology, University La Sapienza, Rome, Italy
J Chemother 13:377-83. 2001..These results, if considered along with the lipophilic nature of the oil which enables it to penetrate the skin, suggest it may be suitable for topical therapeutic use in the treatment of fungal mucosal and cutaneous infections... - In vitro antifungal and anti-elastase activity of some aliphatic aldehydes from Olea europaea L. fruitL Battinelli
Department of Human Physiology and Pharmacology, University La Sapienza, P.le Aldo Moro 5, 00185 Rome, Italy
Phytomedicine 13:558-63. 2006.... - The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assayM G Evandri
Department of Human Physiology and Pharmacology, University La Sapienza, 00185 Rome, Italy
Food Chem Toxicol 43:1381-7. 2005..80 mg/plate) also showed moderate antimutagenicity against the TA98 strain exposed to the direct mutagen 1-nitropyrene. Its antimutagenic property makes lavender oil a promising candidate for new applications in human healthcare... - Atractylis gummifera L. poisoning: an ethnopharmacological reviewC Daniele
Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
J Ethnopharmacol 97:175-81. 2005..New therapeutic approaches could come from immunotherapy research: some studies have already tried to produce polyclonal Fab fragments against the toxic components of Atractylis gummifera... - Suspected adverse reactions associated with herbal products used for weight loss: a case series reported to the Italian National Institute of HealthAnnabella Vitalone
Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy
Eur J Clin Pharmacol 67:215-24. 2011..The aim of this study was to describe suspected adverse reactions (ARs) associated with herbal products used for weight control in Italy... - A pharmacodynamic study on clenbuterol-induced toxicity: beta1- and beta2-adrenoceptors involvement in guinea-pig tachycardia in an in vitro modelGabriela Mazzanti
Department of Human Physiology and Pharmacology, University La Sapienza, P le Aldo Moro, 5 00185 Rome, Italy
Food Chem Toxicol 45:1694-9. 2007..Further experiments are necessary to understand which beta-adrenergic antagonists are of effectiveness to counteract cardiovascular effects in case of intoxication following clenbuterol, or other beta-adrenergic stimulants... - Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cellsLucia Battinelli
Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
Planta Med 69:910-3. 2003..In general, the results obtained point out a similar anti-HIV activity of limonin and nomilin indicating that this activity is not drastically influenced by the structural difference between the two compounds... - Surveillance of suspected adverse reactions to natural health products in ItalyFrancesca Menniti-Ippolito
National Centre for Epidemiology, National Institute of Health, Rome, Italy
Pharmacoepidemiol Drug Saf 17:626-35. 2008..The system has been set up by the Italian National Institute of Health... - In vitro anti-HIV activity of oleanolic acid on infected human mononuclear cellsFabio Mengoni
Department of Infectious and Tropical Diseases, University La Sapienza, Rome, Italy
Planta Med 68:111-4. 2002..7 microM, 24.6 microM and 57.4 microM for in vitro infected PBMC, naturally infected PBMC and M/M, respectively). As regards the mechanism of action, oleanolic acid inhibits in vitro the HIV-1 protease activity... - Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-estersMaria Teresa Gatto
Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, P.le Aldo Moro 5, 00185, Rome, Italy
Bioorg Med Chem 10:269-72. 2002..In particular, 3-O-acyl-quercetines, being more active (IC(16)=10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae, and deserve to be studied further... - Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparationsMei Lu
Department of Pharmacology of Natural Substances and General Physiology, University La Sapienza, Rome, Italy
Planta Med 68:213-6. 2002.... - Antifungal activity of Lavandula angustifolia essential oil against Candida albicans yeast and mycelial formM Tecca
Department of Public Health, University La Sapienza, Rome, Italy
Med Mycol 43:391-6. 2005..At lower concentrations, it inhibits germ tube formation and hyphal elongation, indicating that it is effective against C. albicans dimorphism and may thus reduce fungal progression and the spread of infection in host tissues... - Adverse-event profile of Crataegus spp.: a systematic reviewClaudia Daniele
Department of Pharmacology of Natural Substance and General Physiology, University of Rome, La Sapienza, Rome, Italy
Drug Saf 29:523-35. 2006..Moreover, the unsupervised use of this drug can be associated with problems, especially if given with concomitant medications... - Surveillance of suspected adverse reactions to natural health products: the case of propolisFrancesca Menniti-Ippolito
National Centre for Epidemiology, National Institute of Health, Rome, Italy
Drug Saf 31:419-23. 2008..The public and healthcare practitioners should be aware of the risk of allergic reactions to products derived from bees and a warning should be added to the packaging of these products... - [Pilot study for the surveillance of adverse reactions to herbal preparations and dietary supplements]Francesca Menniti-Ippolito
Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Ann Ist Super Sanita 41:39-42. 2005..After this experience we strongly believe that a system to assess the safety of herbal preparations is needed... - Phenolic compounds from Baseonema acuminatum leaves: isolation and antimicrobial activityMarinella De Leo
Dipartimento di Chimica Bioorganica e Biofarmacia, , Pisa, Italy
Planta Med 70:841-6. 2004..albicans with MICs of 12.5 microg/mL and 25 microg/mL. Compounds 1, 6, 7, and 8 inhibited only one strain of C albicans at the maximum concentration used. None of the phenolic compounds tested was active against the bacteria studied... - Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agentAntonio Bianchi
Traditional Medicine Department, Centro di Orientamento Educativo, Barzio, Italy
Ann Pharmacother 38:1222-5. 2004..mukul ingestion. CONCLUSIONS: Our report describes a case of rhabdomyolysis possibly caused by C. mukul and underlines the need for active surveillance of natural products... - New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorumGabriela Mazzanti
Ann Intern Med 140:W30. 2004 - Antimicrobial diterpenes from the seeds of Cephalotaxus harringtonia var. drupaceaMatteo Politi
Planta Med 69:468-70. 2003..Ferruginol and 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one showed antimicrobial activity against Gram-positive bacteria. None of the six diterpenes was active against the Gram-negative organisms and yeasts tested...