Fulvio Mavilio

Summary

Affiliation: University of Modena and Reggio Emilia
Country: Italy

Publications

  1. ncbi request reprint Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
    Fulvio Mavilio
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Nat Med 12:1397-402. 2006
  2. pmc Genetic modification of somatic stem cells. The progress, problems and prospects of a new therapeutic technology
    Fulvio Mavilio
    Molecular Biology and Centre for Regenerative Medicine at University of Modena and Reggio Emilia, Modena, Italy
    EMBO Rep 9:S64-9. 2008
  3. ncbi request reprint Site-specific integration by the adeno-associated virus rep protein
    Alessandra Recchia
    Center for Regenerative Medicine, University of Modena and Reggio Emilia, Via Gottardi 100, Modena, Italy
    Curr Gene Ther 11:399-405. 2011
  4. pmc Transcription factor binding sites are genetic determinants of retroviral integration in the human genome
    Barbara Felice
    IFOM, FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    PLoS ONE 4:e4571. 2009
  5. doi request reprint Correction of laminin-5 deficiency in human epidermal stem cells by transcriptionally targeted lentiviral vectors
    Francesca Di Nunzio
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Mol Ther 16:1977-85. 2008
  6. doi request reprint PPARdelta is a ligand-dependent negative regulator of vitamin D3-induced monocyte differentiation
    Athina Lymboussaki
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
    Carcinogenesis 30:230-7. 2009
  7. pmc Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination
    Andrea Coluccio
    Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Mol Ther 21:1695-704. 2013
  8. ncbi request reprint Mechanisms of retroviral integration and mutagenesis
    Alessia Cavazza
    Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
    Hum Gene Ther 24:119-31. 2013
  9. pmc Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design
    Giulietta Maruggi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Mol Ther 17:851-6. 2009
  10. doi request reprint Tracking gene-modified T cells in vivo
    Alessandra Recchia
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Methods Mol Biol 506:391-401. 2009

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
    Fulvio Mavilio
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Nat Med 12:1397-402. 2006
    ..These data show that ex vivo gene therapy of JEB is feasible and leads to full functional correction of the disease...
  2. pmc Genetic modification of somatic stem cells. The progress, problems and prospects of a new therapeutic technology
    Fulvio Mavilio
    Molecular Biology and Centre for Regenerative Medicine at University of Modena and Reggio Emilia, Modena, Italy
    EMBO Rep 9:S64-9. 2008
  3. ncbi request reprint Site-specific integration by the adeno-associated virus rep protein
    Alessandra Recchia
    Center for Regenerative Medicine, University of Modena and Reggio Emilia, Via Gottardi 100, Modena, Italy
    Curr Gene Ther 11:399-405. 2011
    ..This region (AAVS1) has characteristics that make it an ideal target for somatic transgenesis...
  4. pmc Transcription factor binding sites are genetic determinants of retroviral integration in the human genome
    Barbara Felice
    IFOM, FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    PLoS ONE 4:e4571. 2009
    ..lentiviral vectors for human gene therapy applications...
  5. doi request reprint Correction of laminin-5 deficiency in human epidermal stem cells by transcriptionally targeted lentiviral vectors
    Francesca Di Nunzio
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Mol Ther 16:1977-85. 2008
    ..These vectors are therefore an effective, and potentially more safe, alternative to MLV-based retroviral vectors in gene therapy of JEB.Molecular Therapy (2008) 16 12, 1977-1985 doi:10.1038/mt.2008.204...
  6. doi request reprint PPARdelta is a ligand-dependent negative regulator of vitamin D3-induced monocyte differentiation
    Athina Lymboussaki
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
    Carcinogenesis 30:230-7. 2009
    ....
  7. pmc Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination
    Andrea Coluccio
    Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Mol Ther 21:1695-704. 2013
    ..GFP-positive clones were observed in all grafts up to 18 weeks post-transplantation. By histological and molecular analysis, we were able to demonstrate highly efficient targeting of the AAVS1 locus in human repopulating EpSCs...
  8. ncbi request reprint Mechanisms of retroviral integration and mutagenesis
    Alessia Cavazza
    Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
    Hum Gene Ther 24:119-31. 2013
    ..This review summarizes the current knowledge on the interactions between retroviruses and the human genome and addresses the impact of target site selection on the safety of retroviral vector-mediated gene therapy...
  9. pmc Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design
    Giulietta Maruggi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Mol Ther 17:851-6. 2009
    ..This study indicates that insertional gene activation is determined by the characteristics of the transcriptional regulatory elements carried by the vector, and is largely independent from the vector type or design...
  10. doi request reprint Tracking gene-modified T cells in vivo
    Alessandra Recchia
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Methods Mol Biol 506:391-401. 2009
    ..This chapter provides a description of these techniques and clues to their rational use in a clinical setting...
  11. doi request reprint Role of CD34 antigen in myeloid differentiation of human hematopoietic progenitor cells
    Simona Salati
    Department of Biomedical Sciences, Biological Chemistry Section, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Stem Cells 26:950-9. 2008
    ....
  12. ncbi request reprint Competitive engraftment of hematopoietic stem cells genetically modified with a truncated erythropoietin receptor
    Fabrizia Urbinati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
    Hum Gene Ther 16:594-608. 2005
    ....
  13. ncbi request reprint Gene therapy of skin adhesion disorders (mini review)
    Alessia Cavazza
    Center for Regenerative Medicine, University of Modena and Reggio Emilia, Via Gottardi 100, 41125 Modena, Italy
    Curr Pharm Biotechnol 13:1868-76. 2012
    ..This paper critically reviews the progress and prospects of gene therapy for skin adhesion defects, and the factors currently limiting its development...
  14. ncbi request reprint Site-specific integration into the human genome: ready for clinical application?
    Alessandra Recchia
    Department of Biochemical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Rejuvenation Res 9:446-9. 2006
    ....
  15. ncbi request reprint The future of gene therapy
    Marina Cavazzana-Calvo
    Immunology and Pediatric Haematology Unit, Hospital Necker, 75743 Paris, Cedex 15, France
    Nature 427:779-81. 2004
  16. ncbi request reprint Long-term engraftment of single genetically modified human epidermal holoclones enables safety pre-assessment of cutaneous gene therapy
    Fernando Larcher
    Epithelial Biomedicine Division, Centro de Investigaciones Energéticas Medioambientales y Tecnologicas, Centro de Investigación Biomédica en Red de Enfermedades, Raras, Madrid, Spain
    Mol Ther 15:1670-6. 2007
    ..Our results provide an experimental basis for previously untested assumptions about the in vivo behavior of epidermal stem cells prospectively isolated in vitro and pave the way for a safer approach to cutaneous gene therapy...
  17. pmc Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy
    Alessandro Aiuti
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    J Clin Invest 117:2233-40. 2007
    ..These data have important implications for the biology of retroviral vectors, the dynamics of genetically modified HSCs, and the safety of gene therapy...
  18. pmc Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells
    Alessandra Recchia
    Cancer Immunotherapy and Gene Therapy Program, and Bone Marrow Transplantation Unit, Istituto Scientifico H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 103:1457-62. 2006
    ..Despite the potentially dangerous interactions with the T cell genome, retroviral integration has therefore little consequence on the safety and efficacy of T cell transplantation...
  19. ncbi request reprint Towards a gene therapy clinical trial for epidermolysis bullosa
    Stefano Ferrari
    Epithelial Stem Cell Research Centre, Veneto Eye Bank Foundation, Ospedale Civile SS Giovanni e Paolo, Sestiere Castello 6777, 30122 Venezia, Italy
    Rev Recent Clin Trials 1:155-62. 2006
    ....
  20. ncbi request reprint The choice of a suitable lentivirus vector: transcriptional targeting
    Francesco Lotti
    HSR Telethon Institute of Gene Therapy, Istituto Scientifico H San Raffaele, Milan, Italy
    Methods Mol Biol 229:17-27. 2003
  21. pmc C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells
    Vanessa Barbaro
    Epithelial Stem Cell Research Center, The Veneto Eye Bank Foundation, H SS Giovanni and Paolo, 30100 Venice, Italy
    J Cell Biol 177:1037-49. 2007
    ....
  22. ncbi request reprint Hot spots of retroviral integration in human CD34+ hematopoietic cells
    Claudia Cattoglio
    Italian Institute of Technology, Unit of Molecular Neuroscience, Istituto Scientifico H San Raffaele, Milan, Italy
    Blood 110:1770-8. 2007
    ..The lower propensity of LV vectors for integrating in potentially dangerous regions of the human genome may be a factor determining a better safety profile for gene therapy applications...
  23. ncbi request reprint Gene therapy in combination with tissue engineering to treat epidermolysis bullosa
    Stefano Ferrari
    Epithelial Stem Cell Research Centre, Veneto Eye Bank Foundation, Ospedale Civile SS Giovanni e Paolo, Sestiere Castello 6777, 30122 Venezia, Italy
    Expert Opin Biol Ther 6:367-78. 2006
    ..The progress made has led the authors' group to submit a request for a Phase I/II ex vivo therapy clinical trial for patients with junctional EB...
  24. ncbi request reprint T Lymphocytes transduced with a lentiviral vector expressing F12-Vif are protected from HIV-1 infection in an APOBEC3G-independent manner
    Giuliana Vallanti
    Molmed SpA, Milan, Italy
    Mol Ther 12:697-706. 2005
    ..Surprisingly, however, the F12-Vif-mediated inhibition does not depend on the reestablishment of the AP3G function...
  25. ncbi request reprint Gene therapy approaches for epidermolysis bullosa
    Stefano Ferrari
    Epithelial Stem Cell Research Centre, Veneto Eye Bank Foundation, 30122 Venice, Italy
    Clin Dermatol 23:430-6. 2005
    ..Gene modification of stem cells in combination with advanced tissue-engineering techniques could therefore represent a realistic option for patients with epidermolysis bullosa...
  26. ncbi request reprint Stem cell plasticity: time for a reappraisal?
    Roberto M Lemoli
    Istituto di Ematologia e Oncologia Medica L e A Seragnoli, Universita di Bologna, Bologna, Italia
    Haematologica 90:360-81. 2005
    ..In addition to the authors' own work, the present review examines articles published in journals covered by the Science Citation Index and Medline...
  27. ncbi request reprint Site-specific integration of functional transgenes into the human genome by adeno/AAV hybrid vectors
    Alessandra Recchia
    Istituto Scientifico H San Raffaele, 20132 Milan, Italy
    Mol Ther 10:660-70. 2004
    ..Nonrandom integration of double-stranded DNA can therefore be obtained ex vivo and in vivoby the use of hybrid Ad/AAV vectors, in the absence of toxicity and with efficiency compatible with gene therapy applications...
  28. ncbi request reprint Myogenic stem cells from the bone marrow: a therapeutic alternative for muscular dystrophy?
    Giuliana Ferrari
    TIGET, Istituto Scientifico H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Neuromuscul Disord 12:S7-10. 2002
    ..Expansion and active recruitment to myogenic differentiation of transplanted haematopoietic cells are therefore critical factors for a future use of bone marrow transplantation in cell/gene therapy of muscular dystrophy...
  29. pmc Transcriptional targeting of lentiviral vectors by long terminal repeat enhancer replacement
    Francesco Lotti
    TIGET, Istituto Scientifico H San Raffaele, 20132 Milan, Italy
    J Virol 76:3996-4007. 2002
    ....