Giuseppe Matullo

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. doi request reprint Next generation sequencing and rare genetic variants: from human population studies to medical genetics
    Giuseppe Matullo
    Dipartimento di Scienze Mediche, Universita di Torino, Torino, Italy
    Environ Mol Mutagen 54:518-32. 2013
  2. pmc Genetic variants associated with increased risk of malignant pleural mesothelioma: a genome-wide association study
    Giuseppe Matullo
    Human Genetics Foundation, HuGeF, Turin, Italy
    PLoS ONE 8:e61253. 2013
  3. doi request reprint ERCC1 haplotypes modify bladder cancer risk: a case-control study
    Fulvio Ricceri
    Unit of Epidemiology and Life Sciences, ISI Foundation, Turin, Italy
    DNA Repair (Amst) 9:191-200. 2010
  4. doi request reprint Association between total number of deaths, diabetes mellitus, incident cancers, and haplotypes in chromosomal region 8q24 in a prospective study
    Simonetta Guarrera
    Department of Genetics, Biology and Biochemistry, Universityof Torino, Torino, Italy
    Am J Epidemiol 175:479-87. 2012
  5. pmc Role of TGF-beta1 haplotypes in the occurrence of myocardial infarction in young Italian patients
    Francesca Crobu
    Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena, Turin, Italy
    BMC Med Genet 9:13. 2008
  6. pmc Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy
    Carlotta Sacerdote
    HuGeF Human Genetics Foundation, Torino, Italy
    Int J Cancer 133:2004-9. 2013
  7. ncbi request reprint Lactase persistence and bitter taste response: instrumental variables and mendelian randomization in epidemiologic studies of dietary factors and cancer risk
    Carlotta Sacerdote
    Centre for cancer Epidemiology and Prevention CPO Piemonte, Turin, Italy
    Am J Epidemiol 166:576-81. 2007
  8. ncbi request reprint Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer
    Carlotta Sacerdote
    Unità di epidemiologia dei tumori, Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino and CPO Piemonte, Torino, Italy
    Mutagenesis 22:281-5. 2007
  9. doi request reprint Involvement of MRE11A and XPA gene polymorphisms in the modulation of DNA double-strand break repair activity: a genotype-phenotype correlation study
    Fulvio Ricceri
    Human Genetics Foundation HuGeF, Turin, Italy
    DNA Repair (Amst) 10:1044-50. 2011
  10. doi request reprint Role of the 12q24.12 locus in the onset of preeclampsia: an Italian case-control study
    Cornelia Di Gaetano
    Department of Genetics, Biology and Biochemistry, University of Turin, Italy
    J Matern Fetal Neonatal Med 25:1228-32. 2012

Detail Information

Publications31

  1. doi request reprint Next generation sequencing and rare genetic variants: from human population studies to medical genetics
    Giuseppe Matullo
    Dipartimento di Scienze Mediche, Universita di Torino, Torino, Italy
    Environ Mol Mutagen 54:518-32. 2013
    ....
  2. pmc Genetic variants associated with increased risk of malignant pleural mesothelioma: a genome-wide association study
    Giuseppe Matullo
    Human Genetics Foundation, HuGeF, Turin, Italy
    PLoS ONE 8:e61253. 2013
    ..These results showed that genetic risk factors may play an additional role in the development of MPM, and that these should be taken into account to better estimate individual MPM risk in individuals who have been exposed to asbestos...
  3. doi request reprint ERCC1 haplotypes modify bladder cancer risk: a case-control study
    Fulvio Ricceri
    Unit of Epidemiology and Life Sciences, ISI Foundation, Turin, Italy
    DNA Repair (Amst) 9:191-200. 2010
    ..A detailed characterization of DNA repair genetic variation is warranted and might ultimately help to identify multiple susceptibility variants that could be responsible for joint effects on the risk...
  4. doi request reprint Association between total number of deaths, diabetes mellitus, incident cancers, and haplotypes in chromosomal region 8q24 in a prospective study
    Simonetta Guarrera
    Department of Genetics, Biology and Biochemistry, Universityof Torino, Torino, Italy
    Am J Epidemiol 175:479-87. 2012
    ..This observation can shed light on the mechanisms underlying reported associations between 8q24 variants and disparate chronic diseases...
  5. pmc Role of TGF-beta1 haplotypes in the occurrence of myocardial infarction in young Italian patients
    Francesca Crobu
    Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena, Turin, Italy
    BMC Med Genet 9:13. 2008
    ..In this study, we evaluated the influence of TGF-beta1 polymorphisms/haplotypes on the onset and progression of AMI in young Italian population...
  6. pmc Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy
    Carlotta Sacerdote
    HuGeF Human Genetics Foundation, Torino, Italy
    Int J Cancer 133:2004-9. 2013
    ..This finding may have clinical implications for the choice of therapy. ..
  7. ncbi request reprint Lactase persistence and bitter taste response: instrumental variables and mendelian randomization in epidemiologic studies of dietary factors and cancer risk
    Carlotta Sacerdote
    Centre for cancer Epidemiology and Prevention CPO Piemonte, Turin, Italy
    Am J Epidemiol 166:576-81. 2007
    ..These results suggest that the LCT and TAS2R38 variants are good candidates for Mendelian randomization studies of cancer and other health outcomes...
  8. ncbi request reprint Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer
    Carlotta Sacerdote
    Unità di epidemiologia dei tumori, Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino and CPO Piemonte, Torino, Italy
    Mutagenesis 22:281-5. 2007
    ..This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms...
  9. doi request reprint Involvement of MRE11A and XPA gene polymorphisms in the modulation of DNA double-strand break repair activity: a genotype-phenotype correlation study
    Fulvio Ricceri
    Human Genetics Foundation HuGeF, Turin, Italy
    DNA Repair (Amst) 10:1044-50. 2011
    ..This suggests that successful DSBR may require both DSBR and non-DSBR mechanisms...
  10. doi request reprint Role of the 12q24.12 locus in the onset of preeclampsia: an Italian case-control study
    Cornelia Di Gaetano
    Department of Genetics, Biology and Biochemistry, University of Turin, Italy
    J Matern Fetal Neonatal Med 25:1228-32. 2012
    ..To our knowledge, no study has been published so far investigating the role of this locus in the pathogenesis of preeclampsia (PE)...
  11. pmc Telomere length variation in juvenile acute myocardial infarction
    Alessia Russo
    Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    PLoS ONE 7:e49206. 2012
    ..Based on present cohort of young Italian patients, the LTL did not represent a marker of acute myocardial infarction nor had a predictive role at medium term follow up...
  12. pmc Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age
    Erica Franco
    Department of Internal Medicine, Cardiology Division, San Giovanni Battista Hospital, University of Turin, Italy
    BMC Med Genet 8:27. 2007
    ....
  13. pmc Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure
    Roberto Bono
    Department of Public Health and Microbiology, University of Turin, Italy, Via Santena 5 bis, Turin, Italy
    Chem Res Toxicol 23:1342-8. 2010
    ..075, Pearson correlation) in the formation of M(1)-dG, only in nonsmokers. Working in the reduction rooms and exposure to air-formaldehyde concentrations higher than 66 microg/m(3) are associated with increased levels of M(1)-dG adducts...
  14. doi request reprint Shorter leukocyte telomere length is independently associated with poor survival in patients with bladder cancer
    Alessia Russo
    Genomic Variation in Human Population and Complex Diseases Unit, Human Genetics Foundation, Turin, Italy Department of Medical Sciences, University of Turin, Turin, Italy
    Cancer Epidemiol Biomarkers Prev 23:2439-46. 2014
    ..Therefore, we investigated the impact of TL on bladder cancer survival...
  15. doi request reprint Validation of the nucleotide excision repair comet assay on cryopreserved PBMCs to measure inter-individual variation in DNA repair capacity
    Alessandra Allione
    Human Genetics Foundation, Turin, Italy
    Mutagenesis 28:65-70. 2013
    ..In the present study the APC-block NER comet assay on cryopreserved PBMCs seemed to be a reliable method to measure DRC variation in epidemiological studies; LCLs were not a good surrogate in this assay...
  16. pmc An overview of the genetic structure within the Italian population from genome-wide data
    Cornelia Di Gaetano
    Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    PLoS ONE 7:e43759. 2012
    ..Northern Italy = 3.040 and Northern Italy vs. CEU = 1.427), warning against confounding effects of hidden relatedness and population substructure in association studies...
  17. pmc Sardinians genetic background explained by runs of homozygosity and genomic regions under positive selection
    Cornelia Di Gaetano
    Department of Medical Sciences, University of Turin, Turin, Italy HuGeF Human Genetics Foundation, Turin, Italy
    PLoS ONE 9:e91237. 2014
    ..With the present study we confirmed the high genetic homogeneity of Sardinia that may be explained by the shared ancestry combined with the action of evolutionary forces...
  18. doi request reprint Is there evidence of involvement of DNA repair polymorphisms in human cancer?
    Fulvio Ricceri
    Human Genetics Foundation, Torino, Italy
    Mutat Res 736:117-21. 2012
    ....
  19. ncbi request reprint Expression of DNA repair and metabolic genes in response to a flavonoid-rich diet
    Simonetta Guarrera
    Institute for Scientific Interchange Foundation, Section of Life Sciences, Viale Settimio Severo 65, Torino, Italy
    Br J Nutr 98:525-33. 2007
    ..Larger studies are needed to clarify the possible effects of flavonoids in vivo; our preliminary results could help to better plan new studies on gene expression and diet...
  20. ncbi request reprint XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review
    Maurizio Manuguerra
    Section of Epidemiology, ISI Foundation, Torino, Italy
    Am J Epidemiol 164:297-302. 2006
    ....
  21. doi request reprint Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients
    Barbara Pardini
    Genomic Variation in Human Population and Complex Diseases and Molecular and Genetic Epidemiology Units, Human Genetics Foundation, 10126 Turin, Italy, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
    Carcinogenesis 36:82-6. 2015
    ..44; 95% CI: 0.20-0.94; adjusted P = 0.03). The present study confirms that variations in miRNA-encoding genes may be an important factor for modulating CRC prognosis and predicting therapy response. ..
  22. pmc Differential Greek and northern African migrations to Sicily are supported by genetic evidence from the Y chromosome
    Cornelia Di Gaetano
    Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    Eur J Hum Genet 17:91-9. 2009
    ..9. The general heterogeneous composition of haplogroups in our Sicilian data is similar to the patterns observed in other major islands of the Mediterranean, reflecting the complex histories of settlements in Sicily...
  23. ncbi request reprint Synergistic effect of renin-angiotensin system and nitric oxide synthase genes polymorphisms in pre-eclampsia
    Chiara Benedetto
    Department of Obstetrics and Gynecology, University of Torino, Torino, Italy
    Acta Obstet Gynecol Scand 86:678-82. 2007
    ..The aim of this study was to assess if interactions among different polymorphisms of the renin-angiotensin system and nitric oxide synthase are involved in the pathogenesis of pre-eclampsia...
  24. doi request reprint Circulating Tissue Factor Levels and Risk of Stroke: Findings From the EPICOR Study
    Licia Iacoviello
    From the Laboratory of Molecular and Nutritional Epidemiology, Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli Is, Italy L I, A D C, A D C, G D G, M B D Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy C A, S G Cancer Registry ASP, Ragusa, Italy G F, R T Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Napoli, Italy A M, S P Department of Medical Sciences, University of Torino, Torino, Italy G M Human Genetics Foundation HuGeF, Turin, Italy G M, C S Unit of Cancer Epidemiology, AO Città della Salute e della Scienza University of Turin, Center for Cancer Prevention CPO Piemonte, Turin, Italy F R, C S and Research Laboratories, Fondazione di Ricerca e Cura Giovanni Paolo II, Campobasso, Italy E N, R L
    Stroke 46:1501-7. 2015
    ..We investigated the association of baseline circulating levels of TF with stroke events occurred in the European Prospective Investigation into Cancer and Nutrition-Italy cohort...
  25. pmc Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects
    Fulvio Ricceri
    Human Genetics Foundation previously at ISI Foundation, Turin, Italy
    Cancer Epidemiol Biomarkers Prev 19:3174-81. 2010
    ..Factors that have been reported to be related to DNA adduct levels include smoking, diet, body mass index (BMI), genetic polymorphisms, the season of collection of biologic material, and air pollutants...
  26. ncbi request reprint Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells
    Federica Saletta
    Section of Life Sciences, ISI Foundation, Turin, Italy
    Cancer Res 67:7088-94. 2007
    ....
  27. doi request reprint DNA repair gene expression level in peripheral blood and tumour tissue from non-small cell lung cancer and head and neck squamous cell cancer patients
    Marina Schena
    SC Oncologia Medica, San Giovanni Battista Hospital, Turin, Italy
    DNA Repair (Amst) 11:374-80. 2012
    ....
  28. pmc A proximity-based method to identify genomic regions correlated with a continuously varying environmental variable
    Cornelia Di Gaetano
    Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy HuGeF, Human Genetics Foundation, Turin, Italy
    Evol Bioinform Online 9:29-42. 2013
    ..Our approach can be applied generally to any measure of association between polymorphic frequencies and continuously varying environmental variables...
  29. ncbi request reprint Association between transforming growth factor beta1 gene polymorphisms and IgA nephropathy
    Sonia Carturan
    Department of Medicine and Experimental Oncology, University of Turin, Turin, Italy
    J Nephrol 17:786-93. 2004
    ..We investigated whether G-800A, C-509T and Leu10-->Pro polymorphisms in the TGF-beta1 gene could be involved in the development and progression of immunoglobulin A nephropathy (IgAN)...
  30. doi request reprint Identification of functional cis-regulatory polymorphisms in the human genome
    Ivan Molineris
    Department of Molecular Biotechnology and Life Sciences, University of Turin, Italy
    Hum Mutat 34:735-42. 2013
    ....
  31. ncbi request reprint Combination of DNA repair gene single nucleotide polymorphisms and increased levels of DNA adducts in a population-based study
    Giuseppe Matullo
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Italy
    Cancer Epidemiol Biomarkers Prev 12:674-7. 2003
    ..18-21.45; five alleles, adjusted OR = 7.65, 95% CI = 0.94-62.2]. Our study suggests that the combined effect of multiple variant alleles may be more important than the investigation of single SNP in modulating DNA repair capacity...