Daniela Massi

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. doi request reprint Atypical Spitzoid melanocytic tumors: a morphological, mutational, and FISH analysis
    Daniela Massi
    Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
    J Am Acad Dermatol 64:919-35. 2011
  2. doi request reprint Notch signaling and the developing skin epidermis
    Daniela Massi
    Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
    Adv Exp Med Biol 727:131-41. 2012
  3. pmc A juvenile case of conjunctival atypical nevus
    Cristina Colarossi
    Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande, CT, Italy
    Diagn Pathol 8:64. 2013
  4. ncbi request reprint Analysis of protease-activated receptor-1 and -2 in human scar formation
    S Materazzi
    Department of Critical Care Medicine and Surgery, University of Florence, Italy
    J Pathol 212:440-9. 2007
  5. ncbi request reprint Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors
    Daniela Massi
    Dipartimento di Patologia Umana ed Oncologia, Universita di Firenze, Florence 50134, Italy
    Hum Pathol 38:1516-25. 2007
  6. ncbi request reprint Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 19:246-54. 2006
  7. pmc Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study
    D Massi
    Department of Human Pathology and Oncology, University of Florence, I 50134 Florence, Italy
    J Clin Pathol 59:166-73. 2006
  8. ncbi request reprint Primary cutaneous osteosarcoma of the scalp: a case report and review of the literature
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    J Cutan Pathol 34:61-4. 2007
  9. ncbi request reprint Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Histopathology 56:251-62. 2010
  10. doi request reprint Inducible nitric oxide synthase expression in melanoma: implications in lymphangiogenesis
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 22:21-30. 2009

Detail Information

Publications125 found, 100 shown here

  1. doi request reprint Atypical Spitzoid melanocytic tumors: a morphological, mutational, and FISH analysis
    Daniela Massi
    Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
    J Am Acad Dermatol 64:919-35. 2011
    ..Identification of the clinical behavior of atypical Spitzoid tumors with conflicting histopathologic features remains controversial...
  2. doi request reprint Notch signaling and the developing skin epidermis
    Daniela Massi
    Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
    Adv Exp Med Biol 727:131-41. 2012
    ..Data from ongoing studies indicate that Notch signaling orchestrates the process of epidermal differentiation and proliferation through the sequential activity of different Notch ligands, receptors and downstream pathways...
  3. pmc A juvenile case of conjunctival atypical nevus
    Cristina Colarossi
    Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande, CT, Italy
    Diagn Pathol 8:64. 2013
    ..The final diagnosis relied on morphological and immunohistochemical characterization of the large epithelioid melanocytic cells, and on the results of FISH analysis...
  4. ncbi request reprint Analysis of protease-activated receptor-1 and -2 in human scar formation
    S Materazzi
    Department of Critical Care Medicine and Surgery, University of Florence, Italy
    J Pathol 212:440-9. 2007
    ....
  5. ncbi request reprint Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors
    Daniela Massi
    Dipartimento di Patologia Umana ed Oncologia, Universita di Firenze, Florence 50134, Italy
    Hum Pathol 38:1516-25. 2007
    ..However, macrophages stimulated by murine melanoma cells secreted a level of NO compatible with an antitumor activity only in the presence of interferon gamma...
  6. ncbi request reprint Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 19:246-54. 2006
    ..These results indicate that the activation of Notch may represent an early event in melanocytic tumor growth and upregulation of Notch signaling may sustain tumor progression...
  7. pmc Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study
    D Massi
    Department of Human Pathology and Oncology, University of Florence, I 50134 Florence, Italy
    J Clin Pathol 59:166-73. 2006
    ..Cutaneous melanoma spreads preferentially through the lymphatic route and sentinel lymph node (SLN) status is regarded as the most important predictor of survival...
  8. ncbi request reprint Primary cutaneous osteosarcoma of the scalp: a case report and review of the literature
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    J Cutan Pathol 34:61-4. 2007
    ..The clinico-pathological features of the case are discussed in light of the rare cases previously described in the literature...
  9. ncbi request reprint Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Histopathology 56:251-62. 2010
    ..The aim was to verify whether the clinical behaviour of purely dermal LMS is different from that of LMS with minimal subcutis invasion...
  10. doi request reprint Inducible nitric oxide synthase expression in melanoma: implications in lymphangiogenesis
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 22:21-30. 2009
    ..Mechanistic studies are needed to address the possibility that inducible nitric oxide synthase controls lymphangiogenesis, dissemination and lymphatic borne metastases...
  11. doi request reprint The impact of histopathologic examination of graft-versus-host disease in the era of reduced-intensity conditioning regimen: a study from the Gruppo Italiano Trapianto di Midollo Osseo
    Daniela Massi
    Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence, Italy
    Hum Pathol 42:254-68. 2011
    ....
  12. pmc S100A13 is a new angiogenic marker in human melanoma
    Daniela Massi
    Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
    Mod Pathol 23:804-13. 2010
    ..Therefore, S100A13 may represent a new angiogenic and prognostic marker in melanoma...
  13. doi request reprint Application of a filtration- and isolation-by-size technique for the detection of circulating tumor cells in cutaneous melanoma
    Vincenzo de Giorgi
    Department of Critical Care Medicine and Surgery, Dermatology Unit, University of Florence, Florence, Italy
    J Invest Dermatol 130:2440-7. 2010
    ..001). CTC detection corroborated by suitable molecular characterization may assist in the identification and monitoring of more appropriate therapies in melanoma patients...
  14. ncbi request reprint Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression
    Francesca Bianchini
    Department of Experimental Pathology and Oncology, University of Florence, Viale G B Morgagni 50, I 50134 Florence, Italy
    Prostaglandins Other Lipid Mediat 83:320-8. 2007
    ..On the whole, the results of in vivo and in vitro studies suggest that COX-2 expressed in TAMs appears to act as an effective biomarker of melanoma progression, and melanoma cells themselves might stimulate COX-2 in macrophages...
  15. ncbi request reprint Vasculogenic mimicry has no prognostic significance in pT3 and pT4 cutaneous melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Hum Pathol 35:496-502. 2004
    ..05). In conclusion, our results suggest that there is a mismatch between vasculogenic mimicry and tumor angiogenesis and do not support any prognostic role of vasculogenic mimicry in thick cutaneous melanoma...
  16. ncbi request reprint Expression of Notch-1 and alteration of the E-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma)
    John Panelos
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 22:959-68. 2009
    ..Downregulation of E-cadherin and diffuse membranous beta-catenin expression suggest a dysregulation of the E-cadherin/beta-catenin complex in Merkel cell carcinoma. This may contribute to local invasion and distant metastasis...
  17. doi request reprint Excess body weight and increased Breslow thickness in melanoma patients: a retrospective study
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Eur J Cancer Prev 22:480-5. 2013
    ..Despite limitations because of both the study design and the relatively small numbers of patients in certain subgroups, overweight status may be associated with an increased Breslow thickness in postmenopausal women...
  18. ncbi request reprint The prognostic impact of the anatomical sites in the 'head and neck melanoma': scalp versus face and neck
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Italy
    Melanoma Res 22:402-5. 2012
    ..7% for scalp. HNM has different and worse prognostic features with respect to other sites, but this trend is not only because of scalp melanoma but is also determined by F&N melanoma, which we believe to be underestimated until now...
  19. doi request reprint Polymorphisms of estrogen receptors: risk factors for invasive melanoma - a prospective study
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Oncology 80:232-7. 2011
    ..8 and 39.5%, respectively. These results suggest that a polymorphism at the AluIrestriction site correlates with a higher proportion of melanoma. Thus, the polymorphism of ERβ could ascribe to a higher susceptibility to melanoma...
  20. ncbi request reprint In vivo characterization of the inflammatory infiltrate and apoptotic status in imiquimod-treated basal cell carcinoma
    Vincenzo de Giorgi
    Dipartimento di Scienze Dermatologiche, Universita degli Studi di Firenze, Florence, Italy
    Int J Dermatol 48:312-21. 2009
    ..Imiquimod use in the treatment of basal cell carcinoma (BCC) has proven to be successful in a large percentage of cases, inducing tumor regression; however, the exact cellular mechanism has not been fully clarified...
  21. doi request reprint Tyrosinase mRNA levels in the blood of uveal melanoma patients: correlation with the number of circulating tumor cells and tumor progression
    Pamela Pinzani
    Department of Clinical Physiopathology, Centre of Experimental and Clinical Oncology, University of Florence, Florence, Italy
    Melanoma Res 20:303-10. 2010
    ..The mRNA tyrosinase levels can be taken as an indirect parameter correlated to the number of CTC isolated from blood by ISET...
  22. doi request reprint Specific challenges in the management of subungual melanoma
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Piazza indipendenza 11, Firenze 50100, Italy
    Expert Rev Anticancer Ther 11:749-61. 2011
    ..The correct management of SUM hinges on early diagnosis and selection of the most appropriate surgical technique. Curative treatment of SUM currently entails surgical excision when the extent of invasion is limited...
  23. ncbi request reprint Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor-C expression in head and neck squamous cell carcinoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    J Pathol 208:439-45. 2006
    ..Taken together, our results indicate that iNOS activity may promote lymphangiogenesis and spread to lymph nodes in HNSCC, with the possible involvement of VEGF-C...
  24. pmc Multiparametric analysis of cell-free DNA in melanoma patients
    Francesca Salvianti
    Department of Clinical Physiopathology, Clinical Biochemistry Unit, Universita di Firenze, Firenze, Italy
    PLoS ONE 7:e49843. 2012
    ..90) and methylated RASSF1A (AUC:0.89).An approach based on the simultaneous determination of three biomarkers (total cfDNA, integrity index 180/67 and methylated RASSF1A) could improve the diagnostic performance in melanoma...
  25. doi request reprint Features of small melanocytic lesions: does small mean benign? A clinical-dermoscopic study
    Vincenzo de Giorgi
    Department of Dermatology, Division of Pathological Anatomy, University of Florence, Florence, Italy
    Melanoma Res 22:252-6. 2012
    ..However, the use of dermoscopy, even if not nullifying, allows a better classification of small, melanocytic lesions through pattern analysis...
  26. doi request reprint Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy
    Riccardo Cicchi
    L E N S and Department of Physics, University of Florence, Sesto Fiorentino, Italy
    J Biophotonics 3:34-43. 2010
    ..This multiple scoring method represents a promising tool to be extended to other collagen disorders, as well as to be used in in-vivo skin-imaging applications...
  27. ncbi request reprint Melanocytic aggregation in the skin: diagnostic clues from lentigines to melanoma
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Via Lorenzo il Magnifico 104, 5019 Florence, Italy
    Dermatol Clin 25:303-20, vii-viii. 2007
    ..The authors have systematically analyzed the clinical and dermoscopic features of melanocytic skin lesions, so as to increase in vivo diagnostic accuracy...
  28. ncbi request reprint Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Hum Pathol 36:676-85. 2005
    ..Conversely, the significance of PAR-2 up-regulation in both benign and malignant melanocytic lesions requires further research...
  29. doi request reprint Estrogens, estrogen receptors and melanoma
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Piazza indipendenza 11, Firenze 50100, Italy
    Expert Rev Anticancer Ther 11:739-47. 2011
    ..Therefore, if future large-scale immunohistochemical and molecular studies point towards ERβ as an important factor in malignant melanoma progression, they will open up novel and targeted prognostic and therapeutic perspectives...
  30. ncbi request reprint Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    Cancer 101:973-8. 2004
    ..In the current study, the authors investigated whether tumor lymphangiogenesis may be related to the risk of lymph node metastasis and to clinical outcome in patients with HNSCC...
  31. ncbi request reprint Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis
    Silvia Moretti
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    Histol Histopathol 24:849-57. 2009
    ..In particular, increased TNF-alpha could contribute to keratinocyte apoptosis, which results in reduced release of melanogenic cytokines and ultimately in melanocyte disappearance...
  32. doi request reprint Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions
    Clelia Miracco
    Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Hum Pathol 41:503-12. 2010
    ..Our results, therefore, indicate that beclin 1 and LC3 II autophagic gene expression is altered also in melanocytic neoplasms...
  33. doi request reprint Increase in FOXP3+ regulatory T cells in GVHD skin biopsies is associated with lower disease severity and treatment response
    Cristina Fondi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Biol Blood Marrow Transplant 15:938-47. 2009
    ..Larger studies are required to confirm that evaluation of Tregs in minimally invasive skin biopsies assists the diagnosis and prognosis of GVHD patients...
  34. doi request reprint BRAFV600E detection in melanoma is highly improved by COLD-PCR
    Pamela Pinzani
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Clin Chim Acta 412:901-5. 2011
    ..Our aim was to investigate COLD-PCR (co-amplification at lower denaturation temperature-PCR) as a new approach for the pre-analytical enrichment of the BRAFV600E variant in formalin fixed paraffin embedded (FFPE) melanoma tissues...
  35. doi request reprint Circulating cell-free DNA in plasma of melanoma patients: qualitative and quantitative considerations
    Pamela Pinzani
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Clin Chim Acta 412:2141-5. 2011
    ..In conclusion, DNA integrity indexes can be considered suitable parameters for monitoring cfDNA fragmentation in melanoma patients...
  36. ncbi request reprint Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, IT 50121 Firenze, Italy
    Acta Derm Venereol 90:283-6. 2010
    ..Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation. Long-term studies are required to clarify the pathogenesis of these rare associations...
  37. ncbi request reprint Dermoscopic features of combined melanocytic nevi
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    J Cutan Pathol 31:600-4. 2004
    ..Conversely, combined nevi including a Spitz nevus component may be difficult to classify even by dermoscopy, thus requiring careful monitoring or surgical excision...
  38. ncbi request reprint Dermoscopy in pigmented squamous cell carcinoma
    Vincenzo de Giorgi
    Departments of Dermatology and Human Pathology and Oncology, University of Florence, Florence, Italy
    J Cutan Med Surg 13:326-9. 2009
    ..However, its potential role has been hampered so far by the fact that little is known about the dermoscopic features of pigmented SCC...
  39. ncbi request reprint Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    J Am Acad Dermatol 54:341-4. 2006
    ..In the light of our experience, pattern analysis is the most reliable method for diagnosing these particular lesions correctly because it allows in-depth morphologic analysis of the few parameters found...
  40. ncbi request reprint Features of regression in dermoscopic diagnosis: a confounding factor? Two clinical, dermoscopic-pathologic case studies
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Dermatol Surg 32:282-6. 2006
    ..Regression may indeed be one of the most confounding dermoscopic parameters because it tends to cover, or rather to destroy, other parameters, thus often hindering a correct diagnosis...
  41. doi request reprint Tumour suppressor gene TP53 mutations in atypical vascular lesions of breast skin following radiotherapy
    Raffaella Santi
    Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
    Histopathology 58:455-66. 2011
    ..The aim of the present study was to investigate alterations of tumour suppressor gene TP53 in a series of radiation-induced AVL and angiosarcomas (AS)...
  42. doi request reprint Circulating benign nevus cells detected by ISET technique: warning for melanoma molecular diagnosis
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Via della Pergola 60, 50132 Florence, Italy
    Arch Dermatol 146:1120-4. 2010
    ..Isolation by size of epithelial tumor cells (ISET) allows the identification of circulating tumor cells by filtration according to size...
  43. doi request reprint Prognostic significance of the alterations of the G1-S checkpoint in localized leiomyosarcoma of the peripheral soft tissue
    John Panelos
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Ann Surg Oncol 18:566-71. 2011
    ....
  44. ncbi request reprint Application of optical coherence tomography in non-invasive characterization of skin vascular lesions
    Camilla Salvini
    Department of Dermatology, University of Florence, Florence, Italy
    Skin Res Technol 14:89-92. 2008
    ..Knowledge of the size and depth of the vascular structures can be useful for the diagnosis and for choosing the best treatment...
  45. doi request reprint Allele specific Taqman-based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients
    Pamela Pinzani
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Clin Chim Acta 411:1319-24. 2010
    ..As this event occurs early in melanoma progression, the quantification of BRAF-mutated alleles in plasma may represent a useful biomarker for noninvasive diagnosis and prediction of response to therapy...
  46. doi request reprint The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway
    Claudia Di Serio
    Department of Critical Care Medicine and Surgery, Geriatric Medicine Unit, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Cancer Lett 267:67-74. 2008
    ..Our data indicate a novel role for Akt in supporting the progression of human melanomas and advocate the need for new treatments targeting PI3K/Akt signaling pathway, to control tumor development and progression...
  47. ncbi request reprint Superficial cutaneous leiomyosarcoma: a rare, misleading tumor
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Am J Clin Dermatol 9:185-7. 2008
    ..We present the case of an 81-year-old man with cutaneous leiomyosarcoma on the forehead...
  48. doi request reprint Outcome of patients with melanoma and histologically negative sentinel lymph nodes: one institution's experience
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Oncology 73:401-6. 2007
    ..The aim of our study was to evaluate over time a cohort of patients who, having undergone SLN treatment, were found negative for metastases using routine histopathological and immunohistochemical analyses...
  49. doi request reprint Estrogen receptor expression in cutaneous melanoma: a real-time reverse transcriptase-polymerase chain reaction and immunohistochemical study
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Via della Pergola 60, 50121 Florence, Italy
    Arch Dermatol 145:30-6. 2009
    ..To evaluate estrogen receptor (ER) expression in human melanoma tissues and in the adjacent healthy skin with the aim of explaining whether the ERalpha:ERbeta expression ratio has a role in neoplastic progression...
  50. ncbi request reprint Possible histopathologic correlates of dermoscopic features in pigmented melanocytic lesions identified by means of optical coherence tomography
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Via degli Alfani, 37 50121 Firenze, Italy
    Exp Dermatol 14:56-9. 2005
    ..The resolution is not high enough to reveal the morphology of the single cells, but it is possible to evaluate the architecture of a lesion...
  51. ncbi request reprint Expression and prognostic significance of matrix metalloproteinases and their tissue inhibitors in primary neuroendocrine carcinoma of the skin
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Hum Pathol 34:80-8. 2003
    ..It is conceivable that future attempts to specifically block MMP-1 and MMP-3 activity may provide a novel means to inhibit invasiveness and distant spread in selected patients with PNC...
  52. ncbi request reprint Fluorescence in-situ hybridization and dermoscopy in the assessment of controversial melanocytic tumors
    Giovanni Ponti
    Departments of aHead and Neck Surgery bPlastic and Reconstructive Surgery cClinical and Diagnostic Medicine and Public Health, Division of Clinical Pathology, University Hospital of Modena and Reggio Emilia, University of Modena and Reggio Emilia, Modena dDepartment of Critical Care Medicine and Surgery, Division of Pathological Anatomy, Florence, Italy
    Melanoma Res 23:474-80. 2013
    ..Cytogenetic abnormalities detected by FISH are markers of malignancy that can be useful in the characterization of difficult-to-diagnose melanocytic tumors, when the dermatologist and the pathologist have a different opinions. ..
  53. ncbi request reprint β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines
    Silvia Moretti
    Section of Clinical, Preventive and Oncologic Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
    Lab Invest 93:279-90. 2013
    ..The observation that β-ARs are upregulated in malignant melanoma tissues support the hypothesis that circulating catecholamines NE and E, by activating their receptors, favour melanoma progression in vivo...
  54. doi request reprint Multiple cutaneous precanceroses and carcinomas from combined iatrogenic/professional exposure to arsenic
    Daniele Torchia
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    Int J Dermatol 47:592-3. 2008
  55. ncbi request reprint Results of surveillance programme aimed at early diagnosis of cutaneous melanoma in high risk Mediterranean subjects
    Paolo Carli
    Department of Dermatology, University of Florence, Italy
    Eur J Dermatol 13:482-6. 2003
    ..To compare the number of observed cases of melanoma in the cohort to that expected number in the general population of the same area...
  56. ncbi request reprint Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism
    Claudia Di Serio
    Department of Critical Care Medicine and Surgery, University of Firenze, Firenze, Italy
    Basic Clin Pharmacol Toxicol 101:63-9. 2007
    ..These data suggest that, in view of the development of PAR1-selective antagonists as therapeutic agents, effects potentially unrelated to PAR1 inhibition should be carefully scrutinized...
  57. ncbi request reprint Pigmented Bowen's disease mimicking cutaneous melanoma: clinical and dermoscopic aspects
    Marcello Stante
    Department of Dermatology, University of Florence, Via degli Alfani 37, 50121 Florence, Italy
    Dermatol Surg 30:541-4. 2004
    ..Pigmented Bowen's disease (BD) (squamous cell carcinoma in situ) has been rarely described among white patients...
  58. ncbi request reprint Keratinocyte growth factor receptors
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Via della Pergola 60, 50100 Florence, Italy
    Dermatol Clin 25:477-85, vii. 2007
    ..This article reviews the architecture, the ligand binding activated-signaling pathways, and the biologic effects of KGFR and EGFR on keratinocytes...
  59. ncbi request reprint Eruptive multiple blue nevi of the penis: a clinical dermoscopic pathologic case study
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    J Cutan Pathol 31:185-8. 2004
    ..Because of the well-known diagnostic value of the blue hue in the diagnosis of malignancy by dermoscopy, a careful examination of these lesions should be made in order to minimize any risk of misclassification with melanoma...
  60. doi request reprint Orbital solitary fibrous tumor: a case report and review of the literature
    Giuseppe Leoncini
    Department of Human Pathology and Oncology, University of Florence, Viale GB Morgagni 85, 50134, Florence, Italy
    Pathol Oncol Res 14:213-7. 2008
    ..We review the clinical, histopathological, and immunohistochemical features of the orbital SFT described so far, with particular emphasis on differential diagnosis with other spindle cell orbital neoplasms...
  61. doi request reprint Combined fluorescence-Raman spectroscopic setup for the diagnosis of melanocytic lesions
    Riccardo Cicchi
    National Institute of Optics, National Research Council INO CNR, Largo E Fermi 6, 50125, Florence, Italy European Laboratory for Non linear Spectroscopy LENS, Via Nello Carrara 1, 50019, Sesto Fiorentino, Italy
    J Biophotonics 7:86-95. 2014
    ..Discrimination of lesions based on their fluorescence and Raman spectra showed good correlation with the subsequent histological examination...
  62. ncbi request reprint Immediate local and regional recurrence after the excision of a polypoid melanoma: tumor dormancy or tumor activation?
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Dermatol Surg 29:664-7. 2003
    ..Here, the case of a woman is discussed in whom the surgical removal of a polypoid melanoma was followed, in less than a month, by local recurrence and locoregional lymph nodal metastases, which were previously clinically absent...
  63. ncbi request reprint Expression of p16 in sinonasal malignant melanoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Virchows Arch 449:667-72. 2006
    ..At variance from cutaneous melanoma, loss of p16 is not correlated with the prognosis of patients affected by sinonasal melanoma...
  64. ncbi request reprint Dermoscopic features of mucosal melanosis
    Francesca Mannone
    Department of Dermatology, University of Florence, Florence, Italy
    Dermatol Surg 30:1118-23. 2004
    ..Melanosis, particularly when occurring on genitalia, can clinically mimic mucosal melanoma thus creating concern in both the patient and the physician...
  65. ncbi request reprint Blue hue in the dermoscopy setting: homogeneous blue pigmentation, gray-blue area, and/or whitish blue veil?
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Via degli Alfani 37, 50121 Florence, Italy
    Dermatol Surg 29:965-7. 2003
    ..An assessment of the lesion by means of dermoscopy was performed. The purpose of this report was to analyze the Blue Hue in dermoscopy with its histopathologic correlates, starting with the discussion of a clinical case...
  66. ncbi request reprint Hyalinizing spindle cell tumor with giant rosettes and low-grade fibromyxoid sarcoma: an immunohistochemical and ultrastructural comparative investigation
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Ultrastruct Pathol 27:349-55. 2003
    ....
  67. ncbi request reprint Dilation of intercellular spaces is associated with laryngo-pharyngeal reflux: an ultrastructural morphometric analysis of laryngeal epithelium
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134, Firenze, Italy
    Eur Arch Otorhinolaryngol 264:907-11. 2007
    ..If this result will be confirmed in larger series it may provide a useful diagnostic tool for the identification of LPR...
  68. ncbi request reprint Tumor angiogenesis as a prognostic factor in thick cutaneous malignant melanoma. A quantitative morphologic analysis
    Daniela Massi
    Dipartimento di Patologia Umana ed Oncologia, Universita degli Studi di Firenze, Florence, Italy
    Virchows Arch 440:22-8. 2002
    ..Its prognostic significance is better assessed by quantification of vessel area, equivalent circle diameter, and microvessel branching, whereas microvessel count and vascular density do not provide significant prognostic information...
  69. doi request reprint Skin metastasis from typical carcinoid tumor of the lung
    Raffaella Santi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    J Cutan Pathol 35:418-22. 2008
    ....
  70. ncbi request reprint The comparative role of immunohistochemistry and electron microscopy in the identification of myogenic differentiation in soft tissue pleomorphic sarcomas
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Ultrastruct Pathol 29:295-304. 2005
    ..In conclusion, the results indicate that immunohistochemistry and electron microscopy can usefully complement each other in the classification of soft tissue pleomorphic sarcomas...
  71. ncbi request reprint Ungual basal cell carcinoma on the fifth toe mimicking chronic dermatitis: case study
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Dermatol Surg 31:723-5. 2005
    ..The finger, toe, and nail unit are rare sites of basal cell carcinoma (BCC). Only a few patients with BCC of the foot have been described in the world literature, and ungual BCC is even less frequent...
  72. ncbi request reprint Idiopathic atrophie blanche
    Lauretta Amato
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    Skinmed 5:151-4. 2006
    ..The patient was treated with dapsone (50 mg p.o. q.d.) and pentoxifylline (400 mg p.o. t.i.d.) with pain relief and complete resolution of the ulcerations after 6 weeks of therapy...
  73. ncbi request reprint Vulvar lichen planus associated with ulcerative colitis. A case report
    Barbara Giomi
    Department of Dermatology, Universita degli Studi di Firenze, Via degli Alfani, 23, 50121, Firenze, Italy
    J Reprod Med 48:209-12. 2003
    ..The condition should be managed by both dermatologists and gynecologists because the association between vulvar LP and other immune-mediated disorders occurs frequently...
  74. ncbi request reprint Disseminated superficial actinic porokeratosis in a patient with Sjögren syndrome
    Margherita Terranova
    The Department of Dermatological Sciences, University of Florence, Florence, Italy
    Skinmed 2:390-1. 2003
  75. doi request reprint Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents
    Romina Nassini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    FASEB J 24:4904-16. 2010
    ..This novel pathway, distinguished from the tissue-damaging effect of NAPQI, may contribute to the risk of COPD and asthma associated with therapeutic APAP use...
  76. ncbi request reprint Clinically and dermoscopically featureless melanoma: when prevention fails
    Paolo Carli
    Department of Dermatology, University of Florence, Italy
    J Am Acad Dermatol 46:957-9. 2002
    ..The risk of false-negative diagnosis by both clinical examination and dermoscopy during melanoma screening as well as the possible role of dermoscopy in the diagnosis of amelanotic melanoma are discussed...
  77. ncbi request reprint Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns
    Alessandro Franchi
    Department of Human Pathology and Oncology, Medical School, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Am J Surg Pathol 26:1597-604. 2002
    ..Moreover, these findings support the hypothesis that SNUC is a separate entity from SCC and NPTC of the sinonasal tract...
  78. ncbi request reprint Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop
    Marco Santucci
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Cancer 97:610-27. 2003
    ....
  79. pmc Pyostomatitis vegetans: cellular immune profile and expression of IL-6, IL-8 and TNF-alpha
    Giuseppe Ficarra
    Reference Center for the Study of Oral Diseases, Florence, Italy
    Head Neck Pathol 4:1-9. 2010
    ..However, the complexity of the cytokine network and their numerous functions require further studies in order to confirm our findings...
  80. ncbi request reprint Images in clinical medicine. Plantar melanoma--a false vegetant wart
    Vincenzo de Giorgi
    Universita di Firenze, 50131 Florence, Italy
    N Engl J Med 355:e13. 2006
  81. ncbi request reprint Radiation-induced cutaneous carcinoma of the head and neck: is there an early role for p53 mutations?
    A Franchi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Clin Exp Dermatol 31:793-8. 2006
    ..Little is known about the molecular mechanisms underlying ionizing radiation-induced carcinogenesis of the skin...
  82. doi request reprint Nonlinear laser imaging of skin lesions
    R Cicchi
    L E N S and Department of Physics, University of Florence, Via Nello Carrara 1, 50019 Sesto Fiorentino, Italy
    J Biophotonics 1:62-73. 2008
    ..Finally, we demonstrated the use of methyl-aminolevulinate as a contrast agent to increase the contrast in BCC border detection. The results obtained represent further support for in-vivo noninvasive imaging of diseased skin...
  83. ncbi request reprint Cutaneous endometriosis: non-invasive analysis by epiluminescence microscopy
    V de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Clin Exp Dermatol 28:315-7. 2003
    ..Within this typical pigmentation there were small red globular structures, but more defined and of a deeper hue, which we called 'red atolls'. ELM thus revealed a distinctive pattern in cutaneous endometriosis...
  84. ncbi request reprint Dermoscopic features of naevus-associated melanoma
    M Stante
    Department of Dermatology, University of Florence, Florence, Italy
    Clin Exp Dermatol 28:476-80. 2003
    ..Atypical pigment networks and regression patterns are the most useful dermoscopic criteria suggested to make a diagnosis of naevus-associated melanoma...
  85. ncbi request reprint Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis
    S Ketabchi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Oral Dis 13:419-25. 2007
    ..Protease-Activated Receptors (PARs) play a role in inflammatory diseases in diverse human tissues. The aim of the study was to investigate the expression of PAR-1, PAR-2, MMP-2, MMP-9, COX-1, and COX-2 in tissues taken from OFG patients...
  86. ncbi request reprint A case of difficult Pyoderma gangrenosum diagnosis. Case report
    S Giorgini
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    G Ital Dermatol Venereol 143:219-23. 2008
    ..We report a case of Pyoderma gangrenosum of difficult diagnosis due to its gradual and slow evolution. We believe that cyclosporine A is a valid drug in the management of this strange disease...
  87. ncbi request reprint Improvement of malignant/benign ratio in excised melanocytic lesions in the 'dermoscopy era': a retrospective study 1997-2001
    P Carli
    Human Pathology and Oncology, University of Florence, Italy
    Br J Dermatol 150:687-92. 2004
    ..Because of the many limitations of studies based on the diagnostic setting of excised lesions, the impact of dermoscopy (epiluminescence microscopy, dermatoscopy) in melanoma screening during practice remains to be established...
  88. ncbi request reprint CDX-2, cytokeratin 7 and cytokeratin 20 immunohistochemical expression in the differential diagnosis of primary adenocarcinomas of the sinonasal tract
    A Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    Virchows Arch 445:63-7. 2004
    ..Staining for CDX-2 and cytokeratin 20 has potential use in separating ITACs from other primary malignant glandular neoplasms of the nasal cavities and paranasal sinuses...
  89. ncbi request reprint Giant exophytic basal cell carcinoma treated with radiotherapy
    R Rossi
    Department of Dermatological Sciences, University of Florence, Italy
    J Eur Acad Dermatol Venereol 16:374-6. 2002
    ..The man refused complete surgical removal and therefore was treated with roentgentherapy, with satisfactory results and no complications in the irradiated area. No recurrences had manifested after 1 year follow-up...
  90. ncbi request reprint Cutaneous collision tumour (melanocytic naevus, basal cell carcinoma, seborrhoeic keratosis): a clinical, dermoscopic and pathological case report
    V de Giorgi
    Department of Dermatology, University of Florence, Via degli Alfani 37, 50121 Florence, Italy
    Br J Dermatol 152:787-90. 2005
    ..Cutaneous collision tumours are extremely difficult to diagnose preoperatively, even with the help of dermoscopy, in particular when one of the lesions is melanocytic...
  91. ncbi request reprint The role of pattern analysis and the ABCD rule of dermoscopy in the detection of histological atypia in melanocytic naevi
    P Carli
    Institute of Dermatology, University of Florence, Via degli Alfani 37, 50121 Florence, Italy
    Br J Dermatol 143:290-7. 2000
    ..Clinical features of melanocytic naevi correlate poorly with the presence, histopathologically, of architectural disorder and cytological atypia, making the detection of histological atypia by means of macroscopic appearance unreliable...
  92. ncbi request reprint Sebaceous carcinoma arising from nevus sebaceus: a case report
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Dermatol Surg 29:105-7. 2003
    ..Sebaceous carcinoma (SC) is a rare, aggressive, malignant tumor that is derived from adnexal epithelium of sebaceous glands that are distributed mostly in the skin of the head, neck, and hair-bearing regions of the body...
  93. ncbi request reprint Multiple pigmented trichoblastomas and syringocystadenoma papilliferum in naevus sebaceous mimicking a malignant melanoma: a clinical dermoscopic-pathological case study
    V de Giorgi
    Department of Dermatology, University of Florence, Via degli Alfani 37, 50121 Firenze, Italy
    Br J Dermatol 149:1067-70. 2003
    ..e. epiluminescence microscopy. In our experience, epiluminescence microscopy does not appear to be more diagnostically accurate than simple clinical examination when diagnosing lesions of the scalp, contrary to other regions...
  94. doi request reprint Atypical Spitz tumour: a 'chameleon' lesion
    V de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Clin Exp Dermatol 33:309-11. 2008
    ..Our case underlines the difficulties present in the controversial chapter of spitzoid melanocytic lesions. The atypical Spitz tumour is a 'chameleon' lesion that can mimic not only melanocytic, but also nonmelanocytic lesions...
  95. ncbi request reprint Circinate sarcoidosis of the face
    Giordana Coronella
    The Department of Dermatologic Sciences, University of Florence, Via della Pergola 58, 50121 Florence, Italy
    Skinmed 2:62-4. 2003
  96. doi request reprint Combined non-linear laser imaging (two-photon excitation fluorescence microscopy, fluorescence lifetime imaging microscopy, multispectral multiphoton microscopy) in cutaneous tumours: first experiences
    V de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    J Eur Acad Dermatol Venereol 23:314-6. 2009
    ..Those techniques offer functional information about the relative quantities of fluorescent molecules, which are correlated with tissue structure in physiological and pathological states...
  97. ncbi request reprint Microsatellite analysis in cutaneous malignant melanoma
    D Massi
    Department of Human Pathology and Oncology, Medical Genetics Unit, University of Florence, Italy
    Melanoma Res 12:577-84. 2002
    ..Genetic analysis of metastatic lesions revealed that the same microsatellite alterations as in the primary tumour are seen, but additional genetic changes may develop during disease progression...
  98. ncbi request reprint Inducible nitric oxide synthase expression in benign and malignant cutaneous melanocytic lesions
    D Massi
    Dipartimento di Patologia Umana ed Oncologia, , Firenze, Italy
    J Pathol 194:194-200. 2001
    ..These data suggest that iNOS may play a role in the malignant transformation of melanocytes and in tumour growth. In addition, iNOS may be useful as an immunohistochemical marker for malignant melanocytic lesions...
  99. ncbi request reprint Vulvar basal cell carcinoma: retrospective study and review of literature
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Via degli Alfani, 37, Firenze 50121, Florence, Italy
    Gynecol Oncol 97:192-4. 2005
    ..The aim of this study is to assess the impact and clinical features of BCCs in the vulva versus other anatomical sites...
  100. ncbi request reprint Eccrine porocarcinoma: a rare but sometimes fatal malignant neoplasm
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Florence, Italy
    Dermatol Surg 33:374-7. 2007
  101. ncbi request reprint Cicatricial alopecia; a dermatopathologic and immunopathologic study of 33 patients (pseudopelade of Brocq is not a specific clinico-pathologic entity)
    L Amato
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    Int J Dermatol 41:8-15. 2002
    ..secondary PB by a combined histopathological and immunopathological study in a series of patients who fulfilled the clinical diagnostic criteria for PB set forth by Braun Falco et al...