Alessandro Martorana

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. doi request reprint L-dopa modulates motor cortex excitability in Alzheimer's disease patients
    Alessandro Martorana
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma, Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    J Neural Transm 115:1313-9. 2008
  2. doi request reprint Dopamine modulates cholinergic cortical excitability in Alzheimer's disease patients
    Alessandro Martorana
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Roma, Italy
    Neuropsychopharmacology 34:2323-8. 2009
  3. doi request reprint Dopamine D₂-agonist rotigotine effects on cortical excitability and central cholinergic transmission in Alzheimer's disease patients
    Alessandro Martorana
    Clinica Neurologica, Dipartimento di Neuroscienze, Centro di Riferimento per la Malattia di Alzheimer, Universita di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy
    Neuropharmacology 64:108-13. 2013
  4. doi request reprint Cerebrospinal fluid levels of Aβ42 relationship with cholinergic cortical activity in Alzheimer's disease patients
    Alessandro Martorana
    Dipartimento di Neuroscienze, Universita di Roma Torvergata, Viale Oxford 81, 00133, Rome, Italy
    J Neural Transm 119:771-8. 2012
  5. doi request reprint Plasmin system of Alzheimer's disease patients: CSF analysis
    Alessandro Martorana
    Department of Neuroscience, University of Rome Tor Vergata, 1 Montpellier Street, 00133, Rome, Italy
    J Neural Transm 119:763-9. 2012
  6. doi request reprint Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?
    Alessandro Martorana
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    CNS Neurosci Ther 16:235-45. 2010
  7. doi request reprint Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients
    Giacomo Koch
    Stroke Unit, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Clin Neurophysiol 122:703-7. 2011
  8. doi request reprint CSF tau levels influence cortical plasticity in Alzheimer's disease patients
    Giacomo Koch
    Dipartimento di Neuroscienze, Policlinico Tor Vergata, Universita di Roma Tor Vergata, Rome, Italy
    J Alzheimers Dis 26:181-6. 2011
  9. doi request reprint In vivo electrophysiology of dopamine-denervated striatum: focus on the nitric oxide/cGMP signaling pathway
    Salvatore Galati
    Division of Neurology, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Synapse 62:409-20. 2008
  10. doi request reprint Abeta1-42 Detection in CSF of Alzheimer's disease is influenced by temperature: indication of reversible Abeta1-42 aggregation?
    Giulia M Sancesario
    Clinical Biochemistry and Molecular Biology, Rome, Italy
    Exp Neurol 223:371-6. 2010

Collaborators

Detail Information

Publications33

  1. doi request reprint L-dopa modulates motor cortex excitability in Alzheimer's disease patients
    Alessandro Martorana
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma, Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    J Neural Transm 115:1313-9. 2008
    ..In addition, considering that L-dopa showed a pharmacological profile similar to the one of cholinomimetics, L-dopa might represent a reliable tool to study new therapeutic perspective and strategies for AD...
  2. doi request reprint Dopamine modulates cholinergic cortical excitability in Alzheimer's disease patients
    Alessandro Martorana
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Roma, Italy
    Neuropsychopharmacology 34:2323-8. 2009
    ..These alterations might be responsible, at least in part, for the progressive cognitive decline observed in AD patients...
  3. doi request reprint Dopamine D₂-agonist rotigotine effects on cortical excitability and central cholinergic transmission in Alzheimer's disease patients
    Alessandro Martorana
    Clinica Neurologica, Dipartimento di Neuroscienze, Centro di Riferimento per la Malattia di Alzheimer, Universita di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy
    Neuropharmacology 64:108-13. 2013
    ..This article is part of a Special Issue entitled 'Cognitive Enhancers'...
  4. doi request reprint Cerebrospinal fluid levels of Aβ42 relationship with cholinergic cortical activity in Alzheimer's disease patients
    Alessandro Martorana
    Dipartimento di Neuroscienze, Universita di Roma Torvergata, Viale Oxford 81, 00133, Rome, Italy
    J Neural Transm 119:771-8. 2012
    ..We suggest that coupling of CSF biomarkers with neurophysiological parameters of central cholinergic function could be important to better detect ongoing mechanisms of neural degeneration in vivo...
  5. doi request reprint Plasmin system of Alzheimer's disease patients: CSF analysis
    Alessandro Martorana
    Department of Neuroscience, University of Rome Tor Vergata, 1 Montpellier Street, 00133, Rome, Italy
    J Neural Transm 119:763-9. 2012
    ..Unfortunately, the CSF detection of plasmin system could not be a useful biomarker for either AD diagnosis or disease progression. However, these findings do not exclude the possible involvement of the plasmin system in AD...
  6. doi request reprint Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?
    Alessandro Martorana
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    CNS Neurosci Ther 16:235-45. 2010
    ....
  7. doi request reprint Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients
    Giacomo Koch
    Stroke Unit, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Clin Neurophysiol 122:703-7. 2011
    ..Mechanisms of synaptic plasticity like long term depression (LTD) are altered in experimental models of Alzheimer's disease (AD). LTD-like plasticity mechanisms has not been yet fully investigated in AD patients...
  8. doi request reprint CSF tau levels influence cortical plasticity in Alzheimer's disease patients
    Giacomo Koch
    Dipartimento di Neuroscienze, Policlinico Tor Vergata, Universita di Roma Tor Vergata, Rome, Italy
    J Alzheimers Dis 26:181-6. 2011
    ..These data could be interpreted as the consequence of CSF t-Tau mediated abnormal excitatory activity and could suggest that CSF t-Tau may impact mechanisms of cortical plasticity...
  9. doi request reprint In vivo electrophysiology of dopamine-denervated striatum: focus on the nitric oxide/cGMP signaling pathway
    Salvatore Galati
    Division of Neurology, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Synapse 62:409-20. 2008
    ..In addition, these findings suggest a functional cross-talk between NO, spontaneously active interneurons, and projection neurons that becomes critical in the parkinsonian state...
  10. doi request reprint Abeta1-42 Detection in CSF of Alzheimer's disease is influenced by temperature: indication of reversible Abeta1-42 aggregation?
    Giulia M Sancesario
    Clinical Biochemistry and Molecular Biology, Rome, Italy
    Exp Neurol 223:371-6. 2010
    ..Moreover, our study suggests that low temperature could induce Abeta1-42 conformational changes and multimeric aggregates in probable AD, but, more importantly, Abeta1-42 aggregation could be reversible...
  11. ncbi request reprint CSF markers in Alzheimer disease patients are not related to the different degree of cognitive impairment
    Alessandro Stefani
    IRCCS Fondazione S Lucia, Rome, Italy
    J Neurol Sci 251:124-8. 2006
    ..Conversely, t-tau concentration correlates with the transition towards marked cognitive impairment...
  12. ncbi request reprint Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy study
    Alessandro Martorana
    Santa Lucia Foundation IRCCS Hospital, Laboratory of Neuroanatomy, Via del Fosso Fiorano 64, Rome, Italy
    Eur J Neurosci 24:732-8. 2006
    ..Such observation reinforces the concept of an involvement of TRPC1 in mGluR1-mediated excitatory inputs in rat dopamine neurons...
  13. ncbi request reprint Neurotensin effects on N-type calcium currents among rat pallidal neurons: an electrophysiological and immunohistochemical study
    Alessandro Martorana
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Synapse 60:371-83. 2006
    ..This hypothesis might have implications on both sensori-motor and associative functions of the GP and should be tested in DA-denervated disease models...
  14. ncbi request reprint AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosis
    Alessandro Stefani
    CERC IRCCS Fondazione Santa Lucia, Rome, Italy
    J Neurol Sci 237:83-8. 2005
    ..VD patients and possibly to improve diagnostic accuracy in clinical forms, improperly classified as "mixed dementia" based on radiological vascular lesions...
  15. ncbi request reprint Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain
    Francesca R Fusco
    Basal Ganglia Unit, Laboratory of Experimental Neurorehabilitation, Santa Lucia Foundation IRCCS, Via Ardeatina 306, Rome 00179, Italy
    Eur J Neurosci 18:1093-102. 2003
    ....
  16. doi request reprint Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis
    Diego Centonze
    Neurologic Clinic, Department of Neuroscience, Tor Vergata University, 00133 Rome, Italy
    J Neurosci 29:3442-52. 2009
    ..Our data establish a link between neuroinflammation and synaptic degeneration and calls for early neuroprotective therapies in chronic inflammatory diseases of the CNS...
  17. doi request reprint The load of amyloid-β oligomers is decreased in the cerebrospinal fluid of Alzheimer's disease patients
    Giulia M Sancesario
    Tor Vergata General Hospital, Faculty of Medicine and Surgery, The University of Rome Tor Vergata, Rome, Italy
    J Alzheimers Dis 31:865-78. 2012
    ..The low amount of Aβ oligomers detected in native CSF of AD may be inversely related to their levels in the brain, as occurs for Aβ monomers, representing a biomarker for the amyloid pathogenic cascade...
  18. doi request reprint Altered parietal-motor connections in Alzheimer's disease patients
    Sonia Bonnì
    IRCCS Fondazione Santa Lucia, Rome, Italy
    J Alzheimers Dis 33:525-33. 2013
    ..Our findings reveal that parieto-frontal cortico-cortical functional connectivity is altered in AD patients, providing further evidence for a disconnection-based interpretation of AD symptoms...
  19. doi request reprint Impaired LTP- but not LTD-like cortical plasticity in Alzheimer's disease patients
    Giacomo Koch
    Fondazione Santa Lucia IRCCS, Rome, Italy
    J Alzheimers Dis 31:593-9. 2012
    ..These results demonstrate the impairment of LTP-like together with normal LTD-like cortical plasticity in AD patients...
  20. doi request reprint Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurobiol Dis 36:51-9. 2009
    ..Our work suggests that life style and experiences can impact the clinical course of inflammatory neurodegenerative diseases by affecting their synaptic bases...
  21. pmc P2Y1 receptor switches to neurons from glia in juvenile versus neonatal rat cerebellar cortex
    Susanna Amadio
    Santa Lucia Foundation, Roma, Italy
    BMC Dev Biol 7:77. 2007
    ..In the CNS, several P2 receptors for extracellular nucleotides are identified on neurons and glial cells to participate to neuron-neuron, glia-glia and glia-neuron communication...
  22. ncbi request reprint Down-regulation of nitrergic transmission in the rat striatum after chronic nigrostriatal deafferentation
    Giuseppe Sancesario
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Neurosci 20:989-1000. 2004
    ....
  23. doi request reprint Effects of simvastatin on neuroprotection and modulation of Bcl-2 and BAX in the rat quinolinic acid model of Huntington's disease
    Stefano Patassini
    Laboratory of Neuroanatomy, Santa Lucia Foundation IRCCS, European Center for Brain Research, Rome, Italy
    Neurosci Lett 448:166-9. 2008
    ..Our findings show that statins could be explored as possible neuroprotective agents for neurodegenerative disorders such as HD...
  24. ncbi request reprint Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response
    Francesca Spadoni
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Synapse 51:194-205. 2004
    ..The suppression of the kappa response only in striatum reinforces the notion of an imbalance of endogenous opiates as relevant in extrapyramidal motor dysfunctions...
  25. ncbi request reprint Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytes
    Francesca R Fusco
    Laboratory of Experimental Neurorehabilitation, Basal Ganglia Section, Santa Lucia Foundation I R C C S, Via Ardeatina 306, 00179 Rome, Italy
    Neurosci Lett 365:137-42. 2004
    ..Res. Tech. 52 (2001) 672], we can speculate that the distribution of TRPC3 in oligodendrocytes plays a role in myelination and or demyelination processes...
  26. ncbi request reprint Frailty among Alzheimer's disease patients
    Giacomo Koch
    Department of Neuroscience, University of Rome Tor Vergata, 1 Montpellier Street 00133 Rome, Italy
    CNS Neurol Disord Drug Targets 12:507-11. 2013
    ..In the absence of other indices we conclude that patients with these features could well be considered "frail" among AD. ..
  27. ncbi request reprint Tissue plasminogen activator is required for corticostriatal long-term potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Neurosci 16:713-21. 2002
    ....
  28. ncbi request reprint Huntingtin distribution among striatal output neurons of normal rat brain
    Francesca R Fusco
    Laboratory of Experimental Neurorehabilitation, Santa Lucia Foundation IRCCS, Via Ardeatina 306, 00179, Rome, Italy
    Neurosci Lett 339:53-6. 2003
    ..Our data showed that striatopallidal neurons co-containing SP and D1a [Surmeier, D.J., Song, W.J., and Yan, Z., J. Neurosci., 16 (1996) 6579-6591] co-localized with huntingtin in a higher proportion than striatonigral neurons...
  29. doi request reprint CSF and clinical hallmarks of subcortical dementias: focus on DLB and PDD
    Alessandro Stefani
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    J Neural Transm 119:861-75. 2012
    ..However, more complete data, possibly collected in fieri during the progressive derangement of cognitive abilities, are needed to improve our ability to decipher and treat these entities...
  30. ncbi request reprint Adult polyglucosan body disease: proton magnetic resonance spectroscopy of the brain and novel mutation in the GBE1 gene
    Roberto Massa
    Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, Roma, Italy
    Muscle Nerve 37:530-6. 2008
    ....
  31. ncbi request reprint D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation
    Alessandro Stefani
    IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Roma, Italy
    Eur J Neurosci 15:815-25. 2002
    ..A direct D2 modulation of calcium conductance in GP may alter GP firing properties and GABA release onto pallidofugal targets...
  32. pmc Apathy as marker of frail status
    Roberta Semprini
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier, 00133 Rome, Italy
    J Aging Res 2012:436251. 2012
    ..Unfortunately available literature largely underestimates the presence of these factors. Thus to better identify markers of frailty, a good neuropsychological assessment and the evaluation of behavioural disturbances are suggested...
  33. ncbi request reprint Kyphoplasty: a new opportunity for rehabilitation of neurologic disabilities
    Salvatore Masala
    Department of Diagnostics for Images and Interventional Radiology, University of Rome Tor Vergata, Policlinico Tor Vergata General Hospital, Rome, Italy
    Am J Phys Med Rehabil 83:810-2. 2004
    ....