I Martinelli

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis
    Valerio De Stefano
    Institute of Haematology, Catholic University, Rome, Italy
    Br J Haematol 135:386-91. 2006
  2. ncbi The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or both
    I Martinelli
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, University of Milan, Italy
    Br J Haematol 111:1223-9. 2000
  3. ncbi Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 87:791-5. 2002
  4. ncbi Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 86:800-3. 2001
  5. ncbi Risk factors in venous thromboembolism
    I Martinelli
    Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 86:395-403. 2001
  6. ncbi Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Epidemiology Unit, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Blood 92:2353-8. 1998
  7. ncbi Genetic risk factors for superficial vein thrombosis
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 82:1215-7. 1999
  8. ncbi Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia
    I Martinelli
    Department of Internal Medicine and Medical Specialties, Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital Policlinico, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 5:98-101. 2007
  9. ncbi Prothrombin A19911G polymorphism and the risk of venous thromboembolism
    I Martinelli
    Department of Internal Medicine and Medical Specialties, A Bianchi Bonomi Haemophilia and Thrombosis Center, University of Milan, and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 4:2582-6. 2006
  10. doi The risk of first venous thromboembolism during pregnancy and puerperium in double heterozygotes for factor V Leiden and prothrombin G20210A
    I Martinelli
    A Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University of Milan and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 6:494-8. 2008

Collaborators

Detail Information

Publications41

  1. ncbi The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis
    Valerio De Stefano
    Institute of Haematology, Catholic University, Rome, Italy
    Br J Haematol 135:386-91. 2006
    ..7-31.4) in overall carriers of factor V Leiden and 30% (95%CI 10.7-60.3) in carriers with a pregnancy-related first VTE, with a risk 6.8 times higher than in women without thrombophilia and with a non pregnancy-related first VTE...
  2. ncbi The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or both
    I Martinelli
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, University of Milan, Italy
    Br J Haematol 111:1223-9. 2000
    ..Anticoagulant prophylaxis seems to be indicated only when transient risk factors for thrombosis coexist with mutations...
  3. ncbi Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 87:791-5. 2002
    ..Among thrombophilic abnormalities, the prothrombin mutation was the weakest risk factor. Thrombosis occurred more frequently in puerperium than in pregnancy, whether or not thrombophilia was diagnosed...
  4. ncbi Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 86:800-3. 2001
    ..On the basis of these findings we recommend that these women receive anticoagulant prophylaxis at least in the postpartum, that should perhaps be extended to the whole pregnancy in homozygous carriers...
  5. ncbi Risk factors in venous thromboembolism
    I Martinelli
    Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 86:395-403. 2001
    ..Prevention of first events and recurrences of venous thromboembolism can be optimized only through a knowledge of the main risk factors, their effect, and their interaction with environmental factors...
  6. ncbi Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Epidemiology Unit, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Blood 92:2353-8. 1998
    ..In addition, individuals with factor V Leiden develop less severe thrombotic manifestations, such as superficial vein thrombosis...
  7. ncbi Genetic risk factors for superficial vein thrombosis
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 82:1215-7. 1999
    ..Hence, a laboratory search of these alterations is recommended in patients with SVT, because it allows the identification of patients at high risk of DVT in whom antithrombotic prophylaxis is particularly warranted...
  8. ncbi Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia
    I Martinelli
    Department of Internal Medicine and Medical Specialties, Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital Policlinico, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 5:98-101. 2007
    ..For prothrombin G20210A, data are scanty and controversial...
  9. ncbi Prothrombin A19911G polymorphism and the risk of venous thromboembolism
    I Martinelli
    Department of Internal Medicine and Medical Specialties, A Bianchi Bonomi Haemophilia and Thrombosis Center, University of Milan, and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 4:2582-6. 2006
    ..The A > G polymorphism at position 19911 of the prothrombin gene is associated with increased plasma prothrombin levels but its role as a risk factor for venous thromboembolism (VTE) is not established...
  10. doi The risk of first venous thromboembolism during pregnancy and puerperium in double heterozygotes for factor V Leiden and prothrombin G20210A
    I Martinelli
    A Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University of Milan and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 6:494-8. 2008
    ..Hence, whether or not these women deserve antithrombotic prophylaxis when pregnant is unknown...
  11. doi Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis
    I Martinelli
    A Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    Eur J Neurol 17:1482-5. 2010
    ..Its role in cerebral sinus-venous thrombosis (CSVT) is not known...
  12. doi The JAK2 V617F mutation in patients with cerebral venous thrombosis
    S M Passamonti
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicina and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
    J Thromb Haemost 10:998-1003. 2012
    ..It is currently unclear whether or not cerebral venous thrombosis, such as splanchnic venous thrombosis, can be the first manifestation of an underlying myeloproliferative neoplasm...
  13. ncbi Mutations in coagulation factors in women with unexplained late fetal loss
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico Maggiore Hospital, University of Milan, Italy
    N Engl J Med 343:1015-8. 2000
    ..Whether any of these mutations is associated with an increased risk of late fetal death is not known...
  14. ncbi Interaction between the G20210A mutation of the prothrombin gene and oral contraceptive use in deep vein thrombosis
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, and Epidemiology Unit, IRCCS Maggiore Hospital, University of Milan, Italy
    Arterioscler Thromb Vasc Biol 19:700-3. 1999
    ..We conclude that carriers of the prothrombin mutation who use oral contraceptives have a markedly increased risk of deep vein thrombosis, much higher than the risk conferred by either factor alone...
  15. doi Next-generation sequencing study finds an excess of rare, coding single-nucleotide variants of ADAMTS13 in patients with deep vein thrombosis
    L A Lotta
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano and Fondazione Luigi Villa, Via Pace 9, Milan, Italy
    J Thromb Haemost 11:1228-39. 2013
    ..The ADAMTS13 and VWF genes encode two interconnected proteins with fundamental hemostatic functions, the disruption of which may result in thrombosis...
  16. ncbi Low borderline plasma levels of antithrombin, protein C and protein S are risk factors for venous thromboembolism
    P Bucciarelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Milan
    J Thromb Haemost 10:1783-91. 2012
    ..They are usually defined by laboratory cut-offs (in our setting 81, 70 and 63 IU dL(-1), respectively), which give only a rough idea of the VTE risk associated with plasma levels of these proteins...
  17. ncbi Plasma levels of activated protein C in healthy subjects and patients with previous venous thromboembolism: relationships with plasma homocysteine levels
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
    Arterioscler Thromb Vasc Biol 18:1371-5. 1998
    ..This study indicates that APC plasma levels are sensitive markers of activation of the hemostatic system in vivo and that Hcy does not interfere with the activation of PC in vivo...
  18. ncbi Pros and cons of thrombophilia testing: pros
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and Department of Internal Medicine, University of Milan, Italy
    J Thromb Haemost 1:410-1. 2003
  19. ncbi Risk of venous thromboembolism after air travel: interaction with thrombophilia and oral contraceptives
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico, Maggiore Hospital, University of Milan, Milan, Italy
    Arch Intern Med 163:2771-4. 2003
    ..To our knowledge, there are no studies investigating whether individuals with thrombophilia and those taking oral contraceptives are more likely to develop venous thromboembolism during flights than those without these risk factors...
  20. ncbi Recurrent late fetal death in women with and without thrombophilia
    Ida Martinelli
    Thromb Haemost 87:358-9. 2002
  21. ncbi Hyperhomocysteinemia in cerebral vein thrombosis
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore, University of Milan, Italy
    Blood 102:1363-6. 2003
    ..5 (95% CI, 5.7-67.3). In conclusion, hyperhomocysteinemia is associated with a 4-fold increased risk of cerebral vein thrombosis; whether or not its correction with vitamins reduces the risk of the disease remains to be demonstrated...
  22. ncbi Embryo implantation after assisted reproductive procedures and maternal thrombophilia
    Ida Martinelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milano, Via Pace, 9, 20122 Milano, Italy
    Haematologica 88:789-93. 2003
    ....
  23. ncbi Thromboembolism in women
    Ida Martinelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Foundation IRCCS Policlinico, Mangiagalli and Regina Elena, University of Milan, Milan, Italy
    Semin Thromb Hemost 32:709-15. 2006
    ..In this review, the relationship between VTE and risk factors specifically of women is discussed, also in relation to coagulation abnormalities causing inherited thrombophilia...
  24. ncbi Oral contraceptive use, thrombophilia and their interaction in young women with ischemic stroke
    Ida Martinelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Italy
    Haematologica 91:844-7. 2006
    ..The risk of ischemic stroke in oral contraceptive users was 13 times higher in women who were also carriers of factor V Leiden and 9 times higher in those who also had hyperhomocysteinemia...
  25. ncbi Polymorphisms of the protein Z-dependent protease inhibitor (ZPI) gene and the risk of venous thromboembolism
    Cristina Razzari
    Thromb Haemost 95:909-10. 2006
  26. pmc Exposure to particulate air pollution and risk of deep vein thrombosis
    Andrea Baccarelli
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Arch Intern Med 168:920-7. 2008
    ..Particulate air pollution has been linked to heart disease and stroke, possibly resulting from enhanced coagulation and arterial thrombosis. Whether particulate air pollution exposure is related to venous thrombosis is unknown...
  27. ncbi Screening of thrombophilia in women with failure of embryo implantation: far from being recommended
    Ida Martinelli
    Haematologica 88:ELT36. 2003
  28. ncbi Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, University of Milano, Italy
    Circulation 110:566-70. 2004
    ..Risk factors for primary upper-extremity DVT are not well established, and the recurrence rate is unknown...
  29. ncbi A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism
    Armando Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Blood 104:3631-4. 2004
    ..In conclusion, hypercoagulability detected by a shortened APTT is independently associated with VTE. This inexpensive and simple test should be considered in the evaluation of the risk of VTE...
  30. ncbi Risk factors for thrombophilia in extrahepatic portal vein obstruction
    Massimo Primignani
    Gastroenterology and Gastrointestinal Endoscopy Service, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milano, Milan, Italy
    Hepatology 41:603-8. 2005
    ..In conclusion, the risk for EHPVO is increased in the presence of thrombophilia resulting from the prothrombin G20210A mutation and from the deficiencies of the naturally occurring anticoagulant proteins, but not from factor V Leiden...
  31. ncbi Pregnancy-associated deep vein thrombosis in a double homozygous carrier of factor V Leiden and prothrombin G20210A
    Angelo Luigi Beretta
    Internal Medicine Unit, Valduce Hospital Como, Italy
    Thromb Haemost 94:1329-30. 2005
  32. ncbi von Willebrand factor and factor VIII as risk factors for arterial and venous thrombosis
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, IRCCS Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    Semin Hematol 42:49-55. 2005
    ..These findings have no therapeutic implication, but they should be taken into account in the assessment of the individual risk profile...
  33. ncbi Combined estrogen-progestin oral contraceptives
    Ida Martinelli
    N Engl J Med 350:307-8; author reply 307-8. 2004
  34. ncbi Economy-class syndrome: media hype or real risk?
    Ida Martinelli
    Haematologica 88:486-8. 2003
  35. doi Inherited thrombophilia and pregnancy complications revisited
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Obstet Gynecol 112:320-4. 2008
    ....
  36. ncbi Pharmacogenetic aspects of the use of oral contraceptives and the risk of thrombosis
    Ida Martinelli
    A Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Ospedale Maggiore and University of Milan, Italy
    Pharmacogenetics 13:589-94. 2003
    ....
  37. ncbi Haemostatic activation in HIV infected patients treated with different antiretroviral regimens
    Angelo Pan
    Istituto di Malattie Infettive e Tropicali, Spedali Civili, Universita di Brescia, Brescia, Italy
    Curr HIV Res 6:70-6. 2008
    ..In conclusion, a) HIV infection per se may alter the haemostatic markers of cardiovascular risk, b) minor differences were observed among the different classes of HIV infected patients, namely between NNRTI and PI treated patients...
  38. ncbi Unusual forms of venous thrombosis and thrombophilia
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Pathophysiol Haemost Thromb 32:343-5. 2002
    ..In conclusion, there is increasing evidence that inherited and environmental risk factors may interact differently in determining VTE in different sites...
  39. ncbi Hormone therapy and thromboembolic disease
    Tullia Battaglioli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, IRCCS Policlinico, Mangiagalli and Regina Elena Foundation, University of Milan, Italy
    Curr Opin Hematol 14:488-93. 2007
    ..To reduce this risk, changes in dosage, composition and route of administration have been made over the years. This review provides a summary of the available evidence and an update on the most recent findings on the issue...
  40. ncbi Molecular characterization of an Italian patient with plasminogen deficiency and ligneous conjunctivitis
    Simona M Siboni
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, University of Milan, Milan, Italy
    Blood Coagul Fibrinolysis 18:81-4. 2007
    ..By this simple strategy the complete sequence analysis of PLG gene was performed, and a previously reported missense homozygous mutation (K19E) was identified...
  41. ncbi Annexin V C/T-1 polymorphism and pregnancy complications
    Franca Franchi
    Haematologica 91:864. 2006
    ..The presence of the -1 CT or TT genotype did not show a protective effect in normal pregnancies...