F Marra

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi Integrin-mediated stimulation of monocyte chemotactic protein-1 expression
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    FEBS Lett 414:221-5. 1997
  2. ncbi Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    Am J Pathol 152:423-30. 1998
  3. ncbi Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 30:951-8. 1999
  4. ncbi Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Gastroenterology 119:466-78. 2000
  5. ncbi Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes
    A Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Italy
    J Biol Chem 276:9945-54. 2001
  6. ncbi Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 29:140-8. 1999
  7. ncbi Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells
    E Efsen
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 33:713-21. 2001
  8. ncbi CXCR3 and alphaEbeta7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes
    F Annunziato
    Center for Research, Transfer, and High Education DENOthe, Dipartimento di Medicina Interna, Universita di Firenze, Viale Morgagni 85, Firenze 50134 Italy
    Gut 55:961-8. 2006
  9. ncbi Role of adipocytokines in hepatic fibrosis
    C Bertolani
    Dipartimento di Medicina Interna, Viale Morgagni 85, I 50134 Florence, Italy
    Curr Pharm Des 16:1929-40. 2010
  10. ncbi Adipokines and liver fibrosis
    F Marra
    Dipartimento di Medicina Interna, Transfer, and High Education MCIDNENT, University of Florence, Italy
    Eur Rev Med Pharmacol Sci 9:279-84. 2005

Collaborators

Detail Information

Publications29

  1. ncbi Integrin-mediated stimulation of monocyte chemotactic protein-1 expression
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    FEBS Lett 414:221-5. 1997
    ..These findings indicate a novel mechanism of MCP-1 regulation possibly relevant in those conditions where HSC interact with an altered extracellular matrix...
  2. ncbi Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    Am J Pathol 152:423-30. 1998
    ..These data expand previous in vitro studies showing that secretion of MCP-1 may contribute to the formation and maintenance of the inflammatory infiltrate observed during chronic liver disease...
  3. ncbi Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 30:951-8. 1999
    ..The results of this study indicate that ERK activation regulates proliferation and chemotaxis of HSC, and modulates nuclear signaling. Acute liver damage in vivo leads to activation of ERK in HSC...
  4. ncbi Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Gastroenterology 119:466-78. 2000
    ..We explored the effects of PPAR-gamma agonists on the biological actions of cultured human HSCs...
  5. ncbi Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes
    A Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Italy
    J Biol Chem 276:9945-54. 2001
    ..These data characterize CXCR3 signaling in pericytes and clarify the relevance of downstream pathways in the modulation of different biologic responses...
  6. ncbi Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 29:140-8. 1999
    ..MCP-1-dependent signals in these cells are not transduced by CCR2 and may be mediated by alternative chemokine receptors. (HEPATOLOGY 1999;29:140-148.)..
  7. ncbi Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells
    E Efsen
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 33:713-21. 2001
    ..These findings indicate that cross-talk between cytokines and a prostaglandin-cAMP pathway differentially regulates the proinflammatory potential of HSC, contributing to the modulation of liver tissue inflammation...
  8. ncbi CXCR3 and alphaEbeta7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes
    F Annunziato
    Center for Research, Transfer, and High Education DENOthe, Dipartimento di Medicina Interna, Universita di Firenze, Viale Morgagni 85, Firenze 50134 Italy
    Gut 55:961-8. 2006
    ....
  9. ncbi Role of adipocytokines in hepatic fibrosis
    C Bertolani
    Dipartimento di Medicina Interna, Viale Morgagni 85, I 50134 Florence, Italy
    Curr Pharm Des 16:1929-40. 2010
    ..The variations in the circulating levels and intrahepatic expression of different adipocytokines in patients with fibrogenic liver diseases are also discussed...
  10. ncbi Adipokines and liver fibrosis
    F Marra
    Dipartimento di Medicina Interna, Transfer, and High Education MCIDNENT, University of Florence, Italy
    Eur Rev Med Pharmacol Sci 9:279-84. 2005
    ..The clinical and experimental findings accumulating on this class of molecules could represent the basis to devise a better management strategy for the patients with chronic liver disease...
  11. ncbi Cytokine receptors and signaling in hepatic stellate cells
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, I 50134 Florence, Italy
    Semin Liver Dis 21:397-416. 2001
    ..In the past decade the major intracellular signaling pathways elicited by these factors in HSCs have been greatly elucidated...
  12. ncbi ADMA correlates with portal pressure in patients with compensated cirrhosis
    F Vizzutti
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Florence, Italy
    Eur J Clin Invest 37:509-15. 2007
    ..We therefore investigated the possible implication of ADMA in chronic liver diseases-induced portal hypertension...
  13. ncbi Review article: the pathogenesis of fibrosis in non-alcoholic steatohepatitis
    F Marra
    Dipartimento di Medicina Interna, University of Florence, Florence, Italy
    Aliment Pharmacol Ther 22:44-7. 2005
    ..Finally, recent developments indicating the possible contribution of cytokines derived from adipose tissue (adipokines) to liver fibrosis is discussed...
  14. ncbi Lack of nitric oxide- and guanosine 3':5'-cyclic monophosphate-dependent regulation of alpha-thrombin-induced calcium transient in endothelial cells of spontaneously hypertensive rat hearts
    P Failli
    Department of Pharmacology, Viale Pieraccini, 6 50139 Florence, Italy
    Br J Pharmacol 130:1468-76. 2000
    ..In WKY ECs, SNAP dose-dependently (10 - 100 microM) reduced also bradykinin-induced calcium transient, while in SHR ECs was ineffective. We concluded that in SHR ECs, the cyclic GMP-dependent regulation of calcium transient is lost...
  15. ncbi Role of hepatic stellate cells in the pathogenesis of portal hypertension
    F Marra
    Dipartimento di Medicina Interna, , Firenze, Italy
    Nefrologia 22:34-40. 2002
  16. ncbi Constitutive activation of the MAPK pathway mediates v-fes-induced mitogenesis in murine macrophages
    E Rovida
    Department of Experimental Pathology and Oncology, , Florence, Italy
    Blood 95:3959-63. 2000
    ..Blood. 2000;95:3959-3963)..
  17. ncbi Coagulation defects in cirrhosis--old dogmas not yet ready for burial
    G Laffi
    Dipartimento di Medicina Interna, University of Florence, Florence, Italy
    J Thromb Haemost 4:2068-9. 2006
  18. ncbi Thiazolidinediones and hepatic fibrosis: don't wait too long
    F Marra
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I-50134 Florence, Italy
    Gut 55:917-9. 2006
  19. ncbi c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells
    P Cirri
    Dipartimento di Scienze Biochimiche, Instituto di Medicina Interna, Universita di Firenze, Italy
    Biochem Biophys Res Commun 239:493-7. 1997
    ..Taken together, these data suggest that c-Src is involved in activation of both STAT1 and 3 in PDGF signal transduction...
  20. ncbi Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+
    P Romagnani
    Department of Physiopathology, Endocrinology Unit, and the Department of Internal Medicine, University of Florence, Florence, Italy
    Blood 97:601-7. 2001
    ....
  21. ncbi Renaming cytokines: MCP-1, major chemokine in pancreatitis
    F Marra
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I-50134 Florence, Italy
    Gut 54:1679-81. 2005
  22. ncbi Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease. A decalogue from the Italian Association for the Study of the Liver (AISF) Expert Committee
    P Loria
    Dipartimento di Medicina Interna, Endocrinologia, Metabolismo e Geriatria, Universita di Modena e Reggio Emilia, Nuovo Ospedale Sant Agostino Estense di Baggiovara, Via del Pozzo 71, Modena, MO, Italy
    Dig Liver Dis 42:272-82. 2010
    ....
  23. ncbi Phosphatidylinositol 3-kinase inhibition enhances human sperm motility
    M Luconi
    Dipartimenti di Fisiopatologia Clinica, , , Italy
    Hum Reprod 16:1931-7. 2001
    ..CONCLUSIONS: Our results suggest a negative role for PI3K in the development and maintenance of sperm motility and suggest a possible use of PI3K inhibitors to enhance motility in cases of asthenozoospermia...
  24. ncbi Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C
    U Arena
    Department of Internal Medicine, University of Firenze, Firenze, Italy
    Gut 57:1288-93. 2008
    ..Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in patients with chronic liver disease...
  25. ncbi Dose dependent and divergent effects of superoxide anion on cell death, proliferation, and migration of activated human hepatic stellate cells
    E Novo
    , Dip Medicina e Oncologia Sperimentale, C so Raffaello 30, 10125 Torino, Italy
    Gut 55:90-7. 2006
    ..CONCLUSIONS: Low non-cytotoxic levels of extracellularly generated O(2)(.-) may stimulate selected profibrogenic responses in human HSC/MFs without affecting proliferation...
  26. ncbi Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans
    E Novo
    Dip Medicina e Oncologia Sperimentale, University of Torino, Italy
    Gut 55:1174-82. 2006
    ..CONCLUSIONS: Human activated HSC/MFs are resistant to most proapoptotic stimuli due to Bcl-2 overexpression and this feature may play a key role in the progression of fibrosis in chronic liver diseases...
  27. ncbi Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin
    C Ostacolo
    Dipartimento di Chimica Farmaceutica e Tossicologica, , Via D. Montesano 49, 80181 Naples, Italy
    J Control Release 99:403-13. 2004
    ..Finally, the enzymatic metabolism of these new derivatives generates not only VE, but also components that can have a further advantageous action on skin...
  28. ncbi Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?
    G Targher
    Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Verona, Italy
    Diabetologia 51:1947-53. 2008
    ..The clinical impact of NAFLD on CVD risk deserves particular attention in view of the implications for screening and surveillance strategies in the growing number of patients with NAFLD...
  29. ncbi Successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant
    F Marra
    Pharmacy and Vaccine Services, BC Centre for Disease Control, Vancouver, Canada
    Int J Tuberc Lung Dis 8:905-9. 2004
    ..Our findings raise the possibility that the CFX and PZA combination was responsible for the hepatic necrosis. The patient also illustrates that active, even MDR tuberculosis is not a contraindication to hepatic transplant...