Francesca Marini

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. doi request reprint The future of pharmacogenetics for osteoporosis
    Francesca Marini
    Metabolic Bone Unit, Department of Surgery and Translation Medicine, University of Florence, Florence, Italy
    Pharmacogenomics 14:641-53. 2013
  2. doi request reprint Pharmacogenetics of osteoporosis: what is the evidence?
    Francesca Marini
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy
    Curr Osteoporos Rep 10:221-7. 2012
  3. doi request reprint Pharmacogenetics of osteoporosis: future perspectives
    Francesca Marini
    Mineral and Bone Metabolism Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    Calcif Tissue Int 84:337-47. 2009
  4. pmc Multiple endocrine neoplasia type 1
    Francesca Marini
    Regional Center for Hereditary Endocrine Tumours, Department of Internal Medicine, University of Florence, Florence, Italy
    Orphanet J Rare Dis 1:38. 2006
  5. pmc Multiple endocrine neoplasia type 2
    Francesca Marini
    Regional Center for Hereditary Endocrine Tumors, Department of Internal Medicine, University of Florence, Florence, Italy
    Orphanet J Rare Dis 1:45. 2006
  6. doi request reprint Genetic epidemiology of Paget's disease of bone in italy: sequestosome1/p62 gene mutational test and haplotype analysis at 5q35 in a large representative series of sporadic and familial Italian cases of Paget's disease of bone
    Alberto Falchetti
    Department of Internal Medicine, University of Florence, Florence, Italy
    Calcif Tissue Int 84:20-37. 2009
  7. doi request reprint Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors
    Alberto Falchetti
    Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Florence, Italy
    Genet Med 11:825-35. 2009
  8. doi request reprint The regulatory network menin-microRNA 26a as a possible target for RNA-based therapy of bone diseases
    Ettore Luzi
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    Nucleic Acid Ther 22:103-8. 2012
  9. ncbi request reprint Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw
    Francesca Marini
    Department of Internal Medicine, University of Florence, Medical School, Florence, Italy
    Front Biosci (Elite Ed) 3:364-70. 2011
  10. pmc The negative feedback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the "Knudson's second hit"
    Ettore Luzi
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    PLoS ONE 7:e39767. 2012

Collaborators

Detail Information

Publications25

  1. doi request reprint The future of pharmacogenetics for osteoporosis
    Francesca Marini
    Metabolic Bone Unit, Department of Surgery and Translation Medicine, University of Florence, Florence, Italy
    Pharmacogenomics 14:641-53. 2013
    ....
  2. doi request reprint Pharmacogenetics of osteoporosis: what is the evidence?
    Francesca Marini
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy
    Curr Osteoporos Rep 10:221-7. 2012
    ....
  3. doi request reprint Pharmacogenetics of osteoporosis: future perspectives
    Francesca Marini
    Mineral and Bone Metabolism Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    Calcif Tissue Int 84:337-47. 2009
    ..In this paper we review the most recent data on pharmacogenetics of osteoporosis, highlighting the presentations at the Second International Meeting on Pharmacogenetics of Osteoarticular Disorders held in Florence in April 2008...
  4. pmc Multiple endocrine neoplasia type 1
    Francesca Marini
    Regional Center for Hereditary Endocrine Tumours, Department of Internal Medicine, University of Florence, Florence, Italy
    Orphanet J Rare Dis 1:38. 2006
    ....
  5. pmc Multiple endocrine neoplasia type 2
    Francesca Marini
    Regional Center for Hereditary Endocrine Tumors, Department of Internal Medicine, University of Florence, Florence, Italy
    Orphanet J Rare Dis 1:45. 2006
    ..At present, surgical treatment offers the only chance of cure and therefore, early clinical and genetic detection and prophylactic surgery in subjects at risk are the main therapeutic goal...
  6. doi request reprint Genetic epidemiology of Paget's disease of bone in italy: sequestosome1/p62 gene mutational test and haplotype analysis at 5q35 in a large representative series of sporadic and familial Italian cases of Paget's disease of bone
    Alberto Falchetti
    Department of Internal Medicine, University of Florence, Florence, Italy
    Calcif Tissue Int 84:20-37. 2009
    ..This may be helpful in estimating the true rate of de novo mutations. We confirm the data on the existence of both a mutational hotspot at the UBA domain of SQSTM1/p62 and a founder effect in the PDB population...
  7. doi request reprint Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors
    Alberto Falchetti
    Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Florence, Italy
    Genet Med 11:825-35. 2009
    ..The ever increrasing combination of genetic and clinical tools will allow early detection of MEN1-associated neoplasms, potentially improving clinical outcomes and quality of life for both affected patients and their relatives...
  8. doi request reprint The regulatory network menin-microRNA 26a as a possible target for RNA-based therapy of bone diseases
    Ettore Luzi
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    Nucleic Acid Ther 22:103-8. 2012
    ....
  9. ncbi request reprint Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw
    Francesca Marini
    Department of Internal Medicine, University of Florence, Medical School, Florence, Italy
    Front Biosci (Elite Ed) 3:364-70. 2011
    ....
  10. pmc The negative feedback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the "Knudson's second hit"
    Ettore Luzi
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    PLoS ONE 7:e39767. 2012
    ..The functional significance of this regulatory mechanism in MEN1 tumorigenesis is also the basis for opening future developments of RNA antagomir(s)-based strategies in the in vivo control of tumorigenesis in MEN1 carriers...
  11. pmc Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget's disease of bone in an Italian family
    Alberto Falchetti
    Department of Internal Medicine, University of Florence, Florence, Italy
    Arthritis Res Ther 7:R1289-95. 2005
    ....
  12. ncbi request reprint A heterozygous frameshift mutation in exon 1 of CDKN1B gene in a patient affected by MEN4 syndrome
    Francesco Tonelli
    Surgical UnitBone Metabolic Diseases UnitDepartment of Surgery and Translational Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur J Endocrinol 171:K7-K17. 2014
    ..The aim of this study was to characterize the molecular basis of a case of MEN1-like syndrome with a neuroendocrine tumor and persistent primary hyperparathyroidism (PHPT)...
  13. ncbi request reprint In vitro effects of oestrogens, antioestrogens and SERMs on pancreatic solid pseudopapillary neoplasm-derived primary cell culture
    Isabella Tognarini
    Department of Internal Medicine, University of Florence Medical School, Florence, Italy
    Cell Oncol 32:331-43. 2010
    ..The controversial expression of oestrogen receptors (ERs) in SPNs, provide a rationale for studying the effects of oestrogenic molecules on SPN development...
  14. doi request reprint Multiple endocrine neoplasms
    Alberto Falchetti
    Surgery Unit, Department of Clinical Physiopathology, University of Florence, 6 50139 Florence, Italy
    Best Pract Res Clin Rheumatol 22:149-63. 2008
    ..If not diagnosed precociously, MTC can be fatal. MEN1 develops after tissue inactivation of both MEN1 gene copies. Activating mutations of c-RET proto-oncogene causes MEN2...
  15. ncbi request reprint Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis
    Francesca Marini
    Department of Internal Medicine, University of Florence, Florence, Italy
    Curr Med Res Opin 24:2609-15. 2008
    ..Polymorphisms of genes encoding enzymes of the mevalonate pathway could modulate the response to amino-bisphosphonate treatment in postmenopausal osteoporosis...
  16. doi request reprint Molecular diagnosis of parathyroid carcinoma: a reality in the near future
    Alberto Falchetti
    University of Florence and Regional Centre for Hereditary Endocrine Tumors, University Hospital of Careggi, Department of Internal Medicine, Unit of Metabolic Bone Diseases, Viale Pieraccini, 6, 50139 Florence, Italy
    Expert Opin Med Diagn 6:27-37. 2012
    ..The latter issue would be of fundamental importance to assist the surgeon in performing a complete resection of all carcinomatous tissue at the time of the initial surgery, allowing for the greatest likelihood of a cure...
  17. ncbi request reprint Germline mutations in MEN1 and BRCA1 genes in a woman with familial multiple endocrine neoplasia type 1 and inherited breast-ovarian cancer syndromes: a case report
    Laura Papi
    Medical Genetics Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Cancer Genet Cytogenet 195:75-9. 2009
    ..We explore genetic and molecular rationales for an association between these neoplastic processes...
  18. ncbi request reprint Genetic aspects of the Paget's disease of bone: concerns on the introduction of DNA-based tests in the clinical practice. Advantages and disadvantages of its application
    Alberto Falchetti
    Regional Center for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, AOUC, Department of Internal Medicine, University of Florence, Florence, Italy
    Eur J Clin Invest 40:655-67. 2010
    ....
  19. ncbi request reprint Azidothymidine induces apoptosis and inhibits cell growth and telomerase activity of human parathyroid cancer cells in culture
    Alberto Falchetti
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Bone Miner Res 20:410-8. 2005
    ..In vitro exposure of these cells to AZT correlated with inhibition of cell proliferation...
  20. pmc Thyroid cancer: current molecular perspectives
    Francesca Giusti
    Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50135 Florence, Italy
    J Oncol 2010:351679. 2010
    ..This review will briefly report on the histological features and the new entity represented by thyroid microcarcinoma and will focus on both environmental and genetic aspects associated with the occurrence of thyroid cancer...
  21. pmc Age-specific effects of estrogen receptors' polymorphisms on the bone traits in healthy fertile women: the BONTURNO study
    Francesco Massart
    Department of Internal Medicine, University of Florence, Florence, Italy
    Reprod Biol Endocrinol 7:32. 2009
    ..Common variants in the genes encoding for estrogen receptor alpha (ESR1) and beta (ESR2) are proposed as candidates for influencing bone phenotypes at the population level...
  22. ncbi request reprint Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor
    Ettore Luzi
    Metabolic Bone Unit, Laboratory of Molecular Genetics, Department of Internal Medicine, University of Florence, Florence, Italy
    J Bone Miner Res 23:287-95. 2008
    ..Using osteoblast precursors obtained from subcutaneous human adipose tissue, we observed that microRNA-26a modulated late osteoblasts differentiation by targeting the SMAD1 transcription factor...
  23. pmc MicroRNA Role in Thyroid Cancer Development
    Francesca Marini
    Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Thyroid Res 2011:407123. 2011
    ..In this paper we reviewed the available data on miRNA deregulation in different thyroid tumors and describe the putative role of miRNA in thyroid cancer development...
  24. pmc Pharmacogenetics of osteoporosis
    Francesca Marini
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence Viale Pieraccini 6, 50139 Florence Italy
    F1000 Biol Rep 2:63. 2010
    ..This review will provide an overview of the pharmacogenetics of osteoporosis, focusing on the major recent advances in the past two years...
  25. ncbi request reprint Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB)
    Alberto Falchetti
    Department of Internal Medicine, Azienda Ospedaliera Careggi, Florence, Italy
    J Bone Miner Res 19:1013-7. 2004
    ..We describe two novel mutations of sequestosome1 in 62 Italian sporadic patients, confirming the role of the encoded protein in this disorder...