Giuliano Mariani

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi Anaplastic thyroid cancer: prevalence, diagnosis and treatment
    S Chiacchio
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    Minerva Endocrinol 33:341-57. 2008
  2. ncbi A review on the clinical uses of SPECT/CT
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma 67, 56126 Pisa, Italy
    Eur J Nucl Med Mol Imaging 37:1959-85. 2010
  3. ncbi Preoperative localization and radioguided parathyroid surgery
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 44:1443-58. 2003
  4. ncbi Radioguided sentinel lymph node biopsy in patients with malignant cutaneous melanoma: the nuclear medicine contribution
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Surg Oncol 85:141-51. 2004
  5. ncbi Radionuclide gastroesophageal motor studies
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 45:1004-28. 2004
  6. ncbi Receptor-mediated tumor targeting with radiolabeled peptides: there is more to it than somatostatin analogs
    Giuliano Mariani
    University of Pisa Medical School Pisa, Italy
    J Nucl Med 47:1904-7. 2006
  7. ncbi Is the "ideal" gamma-probe for intraoperative radioguided surgery conceivable?
    Giuliano Mariani
    University Hospital and University of Pisa Medical School Pisa, Italy
    J Nucl Med 46:388-90. 2005
  8. ncbi Is PET always an advantage versus planar and SPECT imaging?
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma 67, 56126, Pisa, Italy
    Eur J Nucl Med Mol Imaging 35:1560-5. 2008
  9. ncbi Radionuclide evaluation of the lower gastrointestinal tract
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 49:776-87. 2008
  10. ncbi Lymphoscintigraphic and intraoperative detection of the sentinel lymph node in breast cancer patients: the nuclear medicine perspective
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Surg Oncol 85:112-22. 2004

Detail Information

Publications88

  1. ncbi Anaplastic thyroid cancer: prevalence, diagnosis and treatment
    S Chiacchio
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    Minerva Endocrinol 33:341-57. 2008
    ..Surgery, chemotherapy and radiotherapy are the conventional therapeutic strategies performed in the attempt to improve survival. Unfortunately, very often they do not succeed any clinical benefit but only palliative..
  2. ncbi A review on the clinical uses of SPECT/CT
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma 67, 56126 Pisa, Italy
    Eur J Nucl Med Mol Imaging 37:1959-85. 2010
    ..Finally, the applications of SPECT/CT to other clinical disorders or malignant tumours is currently under extensive investigation, with encouraging results in terms of diagnostic accuracy...
  3. ncbi Preoperative localization and radioguided parathyroid surgery
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 44:1443-58. 2003
    ..Specific guidelines should be followed when selecting patients for gamma-probe-guided MIP...
  4. ncbi Radioguided sentinel lymph node biopsy in patients with malignant cutaneous melanoma: the nuclear medicine contribution
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Surg Oncol 85:141-51. 2004
    ..The procedure is becoming the standard of care for patients with cutaneous melanoma because of its high prognostic value that has led to include the procedure in the most recent version of the TNM staging system...
  5. ncbi Radionuclide gastroesophageal motor studies
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 45:1004-28. 2004
    ....
  6. ncbi Receptor-mediated tumor targeting with radiolabeled peptides: there is more to it than somatostatin analogs
    Giuliano Mariani
    University of Pisa Medical School Pisa, Italy
    J Nucl Med 47:1904-7. 2006
  7. ncbi Is the "ideal" gamma-probe for intraoperative radioguided surgery conceivable?
    Giuliano Mariani
    University Hospital and University of Pisa Medical School Pisa, Italy
    J Nucl Med 46:388-90. 2005
  8. ncbi Is PET always an advantage versus planar and SPECT imaging?
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma 67, 56126, Pisa, Italy
    Eur J Nucl Med Mol Imaging 35:1560-5. 2008
  9. ncbi Radionuclide evaluation of the lower gastrointestinal tract
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 49:776-87. 2008
    ..Quantitation is particularly relevant for prognostic purposes and for monitoring the efficacy of therapy...
  10. ncbi Lymphoscintigraphic and intraoperative detection of the sentinel lymph node in breast cancer patients: the nuclear medicine perspective
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Surg Oncol 85:112-22. 2004
    ..Randomized clinical trials should elucidate the impact of avoiding axillary node dissection in patients with a negative sentinel lymph node on the long-term clinical outcome of patients...
  11. ncbi Severity of bone marrow involvement in patients with Gaucher's disease evaluated by scintigraphy with 99mTc-sestamibi
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma 67, I 56126 Pisa, Italy
    J Nucl Med 44:1253-62. 2003
    ..The aim of this study was to assess the reliability of (99m)Tc-sestamibi scintigraphy for direct evaluation of bone marrow involvement...
  12. ncbi Radionuclide therapy and integrated protocols for bone metastases
    S Chiacchio
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    Q J Nucl Med Mol Imaging 55:431-47. 2011
    ..Finally, the available data on combination therapies showing encouraging results as to potential anti-tumor efficacy are also reviewed...
  13. ncbi Radiolabeled WBC scintigraphy in the diagnostic workup of patients with suspected device-related infections
    Paola A Erba
    Department of Translational Research and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy Electronic address
    JACC Cardiovasc Imaging 6:1075-86. 2013
    ....
  14. ncbi A study of the possibility of curing Graves' disease based on the desired reduction of thyroid mass (volume) as a consequence of 131I therapy: a speculative paper
    Antonio C Traino
    Sezione di Fisica Medica, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    Nucl Med Commun 27:439-46. 2006
    ..In this paper the relationship between maximum uptake of 131I, fractional reduction of thyroid volume and outcome of Graves' disease is discussed...
  15. ncbi The role of 99mTc-tetrofosmin scintigraphy for staging patients with laryngeal cancer
    Bruno Fattori
    Ear, Nose and Throat Unit, Department of Neurosciences, University of Pisa Medical School, Pisa, Italy
    Cancer Biother Radiopharm 20:27-35. 2005
    ..56 for CT and J = 0.50 for (99m)Tc-tetrofosmin scintigraphy). (99m)Tc-tetrofosmin scintigraphy is a useful complement to CT for staging laryngeal tumors, especially for detecting metastatic lymph nodes and distant metastases...
  16. doi Current role of 111In-DTPA-octreotide scintigraphy in diagnosis of thymic masses
    Federica Guidoccio
    Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy
    Tumori 97:191-5. 2011
    ..The aim of this study was to further investigate the role of radionuclide techniques in the diagnosis, staging and follow-up of these tumors...
  17. ncbi Radioguided sentinel lymph node biopsy in malignant cutaneous melanoma
    Giuliano Mariani
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 43:811-27. 2002
    ....
  18. doi Optimal detection of sentinel lymph node metastases by intraoperative radioactive threshold and molecular analysis in patients with melanoma
    Gianpiero Manca
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 49:1769-75. 2008
    ....
  19. doi Clinical impact of SPECT/CT with In-111 biotin on the management of patients with suspected spine infection
    Elena Lazzeri
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    Clin Nucl Med 35:12-7. 2010
    ..Early identification and localization of spine infection is necessary for adequate therapeutic strategy. To localize the precise site of infection we evaluated In-111 Biotin SPECT/CT versus planar and SPECT imaging...
  20. doi Adrenal masses in patients with cancer: PET/CT characterization with combined CT histogram and standardized uptake value PET analysis
    Marzio Perri
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Italy
    AJR Am J Roentgenol 197:209-16. 2011
    ..Our purpose was to determine the diagnostic performance of 18F-FDG PET/CT for characterizing adrenal masses in patients with cancer, combining standardized uptake value (SUV) and CT histogram analysis...
  21. ncbi Off-label use of sunitinib in patients with advanced, epithelial thyroid cancer: a retrospective analysis
    Giuseppe Pasqualetti
    Geriatrics Unit, Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Recent Pat Endocr Metab Immune Drug Discov 6:171-6. 2012
    ..These results confirm sunitinib as a potential useful tool for the treatment of advanced thyroid cancers and may open the way for new patents of molecules with more specific target selectivity...
  22. doi The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with iodine-131
    Angela Dardano
    Geriatrics and Gerontology Section, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Thyroid 22:318-24. 2012
    ....
  23. doi Time course of Paclitaxel-induced apoptosis in an experimental model of virus-induced breast cancer
    Paola A Erba
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 51:775-81. 2010
    ..This study was performed to define the time course of apoptosis induced by the chemotherapeutic agent paclitaxel in a model of virus-induced murine breast cancer...
  24. doi Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa and CNR Institute of Clinical Physiology, Via Roma, 67, 56126, Pisa, Italy
    Eur J Nucl Med Mol Imaging 36:137-43. 2009
    ..To evaluate the association of gallium-67 ((67)Ga)-citrate thyroid uptake with the presence of thyroid disorders in patients with sarcoidosis (S patients)...
  25. doi 99mTc-sestamibi scintigraphy to monitor the long-term efficacy of enzyme replacement therapy on bone marrow infiltration in patients with Gaucher disease
    Paola A Erba
    Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy
    J Nucl Med 54:1717-24. 2013
    ..Assessing the skeletal response to enzyme replacement therapy (ERT) in Gaucher disease (GD) is problematic. We investigated the reliability of (99m)Tc-sestamibi scintigraphy in monitoring changes in bone marrow involvement induced by ERT...
  26. ncbi Clinical benefit of bone-targeted radiometabolic therapy with 153Sm-EDTMP combined with chemotherapy in patients with metastatic hormone-refractory prostate cancer
    Sergio Ricci
    Division of Medical Oncology, Department of Oncology, University Hospital, Pisa, Italy
    Eur J Nucl Med Mol Imaging 34:1023-30. 2007
    ..We retrospectively investigated the possible synergistic effect on survival of 153Sm-EDTMP (given to HRPC patients for bone pain palliation) and chemotherapy...
  27. ncbi Comparison of different thyroid committed doses in radioiodine therapy for Graves' hyperthyroidism
    Mariano Grosso
    Regional Center of Nuclear Medicine, University of Pisa Medical School, I 56126 Pisa, Italy
    Cancer Biother Radiopharm 20:218-23. 2005
    ....
  28. doi Possibility of limiting the un-justified irradiation in (131)I therapy of Graves' disease: a thyroid mass-reduction based method for the optimum activity calculation
    Antonio C Traino
    Sezione di Fisica Medica, U O Fisica Sanitaria, Azienda Ospedaliero Universitaria Pisana, Via Roma 67, I56125 Pisa, Italy
    Phys Med 26:71-9. 2010
    ..In this paper a new approach to the (131)I therapy in Graves' disease, based on the optimum value of the final thyroid mass, is presented...
  29. ncbi Cerebral blood flow in depressed patients with systemic lupus erythematosus
    Giampiero Giovacchini
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Rheumatol 37:1844-51. 2010
    ..To characterize the neural circuitry involved in depression associated with systemic lupus erythematosus (SLE), we used single photon emission computed tomography (SPECT) to study regional cerebral blood flow (CBF) in patients with SLE...
  30. doi 111In-DTPA-Biotin uptake by Staphylococcus aureus
    Paola Anna Erba
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Pisa, Italy
    Nucl Med Commun 31:994-7. 2010
    ..Our data seem to demonstrate a passive transport of In-DTPA-Biotin into the cells of the microorganisms...
  31. ncbi Assessment of swallowing by oropharyngoesophageal scintigraphy in patients with amyotrophic lateral sclerosis
    Bruno Fattori
    Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy
    Dysphagia 21:280-6. 2006
    ....
  32. ncbi Sentinel lymph node mapping in melanoma: the issue of false-negative findings
    Gianpiero Manca
    From the Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo Department of Oncology, University of Pisa Medical School, Pisa, Italy and Department of Radiology, University of Southern California, Los Angeles, CA
    Clin Nucl Med 39:e346-54. 2014
    ..Standardization and accuracy of SLN identification, removal, and analysis are required. ..
  33. doi Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors
    Grazia Chiellini
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    J Endocrinol 213:223-30. 2012
    ..Thus, while T1AM has a systemic distribution, TAARs are only expressed in certain tissues suggesting that other high-affinity molecular targets besides TAARs exist...
  34. ncbi Detection of bilateral, multifocal breast cancer and assessment of tumour response to neoadjuvant chemotherapy by Tc-99m sestamibi imaging - a case report
    Mariano Grosso
    Regional Cetre of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy
    Nucl Med Rev Cent East Eur 11:70-2. 2008
    ..Furthermore, Tc-99m sestamibi scintimammography was effective in monitoring response to chemotherapy in the studied case...
  35. doi Scintigraphic imaging of vertebral osteomyelitis with 111in-biotin
    Elena Lazzeri
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Italy
    Spine (Phila Pa 1976) 33:E198-204. 2008
    ..All patients suspected to have vertebral infection underwent radiologic imaging and In-Biotin scintigraphy...
  36. doi FDG-PET in cardiac infections
    Paola A Erba
    Regional Center of Nuclear Medicine, Department of Translational Research and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Semin Nucl Med 43:377-95. 2013
    ....
  37. doi Added value of 99mTc-HMPAO-labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis
    Paola A Erba
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 53:1235-43. 2012
    ....
  38. doi Higher level gait disorders in subcortical chronic vascular encephalopathy: a single photon emission computed tomography study
    Maria Chiara Carboncini
    Neurorehabilitation Unit, Department of Neurosciences, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Age Ageing 38:302-7. 2009
    ..The aim of the study was to investigate brain activation during walking in subjects with high-level gait disorders due to chronic subcortical vascular encephalopathy...
  39. ncbi Microdosing, imaging biomarkers and SPECT: a multi-sided tripod to accelerate drug development
    Ernest K J Pauwels
    University Medical School Pisa, Pisa, Italy
    Curr Pharm Des 15:928-34. 2009
    ..Eventually this approach facilitates and accelerates new drug approval. The present paper highlights how these techniques make drug development easier in the field of oncology and neurology...
  40. doi Creatinine clearance, cystatin C, beta2-microglobulin and TATI as markers of renal function in patients with proteinuria
    Gianfranco Tramonti
    Nephrology Unit, Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Nephrol 25:976-82. 2012
    ..The aim of this study was to examine the relationship between CrCl, CYST, ß(2)-microglobulin (B2M) and TATI, with glomerular filtration rate (GFR) in patients with different levels of proteinuria...
  41. ncbi Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1485-90. 2007
    ..Forty healthy subjects and 40 patients with autoimmune thyroiditis served as control groups...
  42. doi No evidence of chromosome damage in children and adolescents with differentiated thyroid carcinoma after receiving 131I radiometabolic therapy, as evaluated by micronucleus assay and microarray analysis
    Giovanni Federico
    Department of Pediatrics, Unit of Pediatric Endocrinology and Diabetes, Azienda Ospedaliero Universitaria Pisana, Ospedali Riuniti S Chiara, Via Roma 67, 56126, Pisa, Italy
    Eur J Nucl Med Mol Imaging 35:2113-21. 2008
    ....
  43. ncbi Simultaneous detection of breast tumor resection margins and radioguided sentinel node biopsy using an intraoperative electronically collimated probe with variable energy window: a case report
    Gianpiero Manca
    From the Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy and Breast Unit, University Hospital of Pisa, Department of Oncology Transplants and Advanced Technologies in Medicine, University of Pisa, Italy
    Clin Nucl Med 36:e196-8. 2011
    ....
  44. ncbi Intraoperative radioguided sentinel lymph node biopsy in non-small cell lung cancer
    Franca M A Melfi
    Division of Thoracic Surgery, Cardiac and Thoracic Department, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Cardiothorac Surg 23:214-20. 2003
    ..The aim of this study was to determine the accuracy and the role of the sentinel lymph node (SLN) technique in patients with early non-small cell lung cancer (NSCLC)...
  45. ncbi Cerebral perfusional effects of cholinesterase inhibitors in Alzheimer disease
    Roberto Ceravolo
    Department of Neuroscience, University of Pisa, Italy
    Clin Neuropharmacol 27:166-70. 2004
    ..These data suggest that cognitive or behavioral benefits after ChE inhibitor therapy are related to a clear increase of rCBF in crucial areas specifically involved in the attentional and limbic networks...
  46. ncbi Radioimmunotherapy with radretumab in patients with relapsed hematologic malignancies
    Paola A Erba
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 53:922-7. 2012
    ....
  47. doi Radio-guided thoracoscopic surgery (RGTS) of small pulmonary nodules
    Marcello Carlo Ambrogi
    Division of Thoracic Surgery, Cardiac Thoracic and Vascular Department, University of Pisa, Via Paradisa, 2, 56124, Pisa, Italy
    Surg Endosc 26:914-9. 2012
    ..Difficulties in localizing smaller and deeper nodules have been approached with different techniques. Herein we report our 13-years' experience with radio-guided thoracoscopic resection...
  48. ncbi Role of 18F-DOPA PET/CT in diagnosis and follow-up of adrenal and extra-adrenal paragangliomas
    Alessandra Bacca
    From the Department of Clinical and Experimental Medicine and Regional Center of Nuclear Medicine, University of Pisa Department of Radiodiagnostic, Vascular, and Interventional Radiology and Nuclear Medicine and Medical Genetics Laboratory, Department of Medical Laboratories, University Hospital of Pisa and Department of Surgical, Molecular, Clinical Pathology and of Critical Care, University of Pisa, Pisa, Italy
    Clin Nucl Med 39:14-20. 2014
    ..The objective of this study was to establish the clinical value of F-DOPA PET/CT in patients with adrenal and extra-adrenal paragangliomas (PGLs)...
  49. ncbi A predictive mathematical model for the calculation of the final mass of Graves' disease thyroids treated with 131I
    Antonio C Traino
    Sezione di Fisica Medica U O Fisica Sanitaria, Azienda Ospedaliera Universitaria Pisana, Via Roma 67, 56125 Pisa, Italy
    Phys Med Biol 50:2181-91. 2005
    ..81). The possibility, for the physician, to decide a therapeutic activity based on the desired decrease of thyroid mass instead of on a fixed thyroid absorbed dose could be a new opportunity to cure Graves' disease...
  50. doi Fatty acid facts, Part IV: docosahexaenoic acid and Alzheimer's disease. A story of mice, men and fish
    Ernest K J Pauwels
    Leiden University Medical Center, Leiden, the Netherlands Dept Nuclear Medicine, Pisa University Medical School, Pisa, Italy
    Drug News Perspect 22:205-13. 2009
    ..This review will provide an overview on the available knowledge with regard to the role of DHA in AD with a focus on mechanistic and epidemiological investigations...
  51. ncbi Evaluation of renal function and upper urinary tract morphology in the ileal orthotopic neobladder with no antireflux mechanism
    Andrea Minervini
    Department of Surgery, Nuclear Medicine Division, University of Pisa, Ospedale S Chiara, Via Roma 67, 56122 Pisa, Italy
    J Urol 173:144-7. 2005
    ....
  52. ncbi Formation of micronuclei and of clastogenic factor(s) in patients receiving therapeutic doses of iodine-131
    Michela Ballardin
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Pisa, Italy
    Mutat Res 514:77-85. 2002
    ..The possibility of reducing the genotoxic activity of radionuclide therapy by chemoprevention of CFs with antioxidant drugs remains to be explored...
  53. ncbi Metastatic prostate cancer after orchiectomy, radiotherapy, and testosterone replacement in a patient with bilateral seminoma
    Francesca Manassero
    Department of Urology, University of Pisa, Ospedale Santa Chiara, Via Roma 67, 56126 Pisa, Italy
    J Androl 28:10-2. 2007
  54. ncbi Risk factors for development of coronary heart disease in patients with acromegaly: a five-year prospective study
    Fausto Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124, Pisa, Italy
    J Clin Endocrinol Metab 92:4271-7. 2007
    ..Data on coronary heart disease (CHD) are scanty and matter of argument in acromegalic patients...
  55. ncbi Clinical feasibility of two-step streptavidin/111In-biotin scintigraphy in patients with suspected vertebral osteomyelitis
    Elena Lazzeri
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    Eur J Nucl Med Mol Imaging 31:1505-11. 2004
    ..The objective of this investigation was to determine the diagnostic performance of two-step streptavidin/111In-biotin imaging for evaluating patients with suspected vertebral osteomyelitis...
  56. ncbi Inflammation and infection: imaging properties of 18F-FDG-labeled white blood cells versus 18F-FDG
    Daniela Pellegrino
    Nuclear Medicine Division, Department of Oncology, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 46:1522-30. 2005
    ..In the present study, the imaging properties of both radiotracers were compared in sterile and septic inflammation models...
  57. ncbi Effects of long-term Donepezil therapy on rCBF of Alzheimer's patients
    Flavio Nobili
    Clinical Neurophysiology Service, Department of Internal Medicine, University of Genoa, Viale Benedetto XV, 6 I 16132 Genoa, Italy
    Clin Neurophysiol 113:1241-8. 2002
    ....
  58. ncbi Brain perfusion follow-up in Alzheimer's patients during treatment with acetylcholinesterase inhibitors
    Flavio Nobili
    Clinical Neurophysiology, Department of Internal Medicine, University of Genoa, Italy
    J Nucl Med 43:983-90. 2002
    ..The aim of this study was to evaluate brain perfusion changes by SPECT in AD patients during chronic AChEI therapy in relation to their cognitive evolution...
  59. ncbi Analysis of technical and clinical variables affecting sentinel node localization in patients with breast cancer after a single intradermal injection of 99mTc nanocolloidal albumin
    Domenico Rubello
    Nuclear Medicine Service, S Maria della Misericordia Rovigo Hospital, Rovigo, Italy
    Nucl Med Commun 25:1119-24. 2004
    ....
  60. ncbi Hand-held gamma probe or hand-held miniature gamma camera for minimally invasive parathyroidectomy: competition, evolution or synergy?
    Domenico Rubello
    Eur J Nucl Med Mol Imaging 34:162-4. 2007
  61. ncbi The incidental discovery of follicular thyroid cancer with in-111 pentetreotide scintigraphy in a patient with carcinoid tumor of the lung
    Giuseppe Villa
    Nuclear Medicine Service, University of Genoa Medical School, Genoa, Italy
    Clin Nucl Med 28:45-6. 2003
  62. ncbi Contribution of SLN investigation with 99mTc-nanocolloid in clinical staging of thyroid cancer: technical feasibility
    Maria Rosa Pelizzo
    Nuclear Medicine, PET Unit, S Maria della Misericordia Hospital, Istituto Oncologico Veneto IOV, Viale Tre Martiri, 140, 45100, Rovigo, and Department of Surgical Science, University of Padova, Italy
    Eur J Nucl Med Mol Imaging 34:934-8. 2007
    ..The aim of this study was to evaluate the feasibility of preoperative 99mTc-nanocolloid lymphoscintigraphy and an intra-operative SLN procedure in the management of PTC patients...
  63. ncbi Minimally invasive radioguided parathyroidectomy: an attractive therapeutic option for elderly patients with primary hyperparathyroidism
    Domenico Rubello
    Nuclear Medicine Service, S Maria della Misericordia Rovigo Hospital, Azienda ULSS 18 Rovigo, Istituto Oncologico Veneto, Viale Tre Martiri 140, 45100 Rovigo, Italy
    Nucl Med Commun 25:901-8. 2004
    ..The aim of the present study was to define the efficacy of minimally invasive radioguided surgery (MIRS) in PHPT patients with a high probability of a solitary PA with particular regard to benefits achievable in elderly patients...
  64. ncbi Radionuclide therapy with iodine-125 and other auger-electron-emitting radionuclides: experimental models and clinical applications
    Lisa Bodei
    Nuclear Medicine Division, European Institute of Oncology, Milan, Italy
    Cancer Biother Radiopharm 18:861-77. 2003
    ..Investigators continue to seek molecules that can carry Auger-electron emitters to nuclear DNA, especially those radionuclides with higher Auger-electron yields and varying half-lives...
  65. ncbi Radioiodine treatment with 30 mCi after recombinant human thyrotropin stimulation in thyroid cancer: effectiveness for postsurgical remnants ablation and possible role of iodine content in L-thyroxine in the outcome of ablation
    Daniele Barbaro
    Sezione Endocrinologia, Diabetologia e Malattie Metaboliche, Spedali Riuniti, Azienda Sanitaria Locale 6, 57100 Livorno, Italy
    J Clin Endocrinol Metab 88:4110-5. 2003
    ..The cost of rhTSH seems modest compared with the high cost of complex therapeutic regimens in other areas of oncology and in consideration of the well-being of patients and of the high level of effectiveness of the treatment...
  66. ncbi Radiotoxicity of iodine-125 and other auger-electron-emitting radionuclides: background to therapy
    S James Adelstein
    Experimental Nuclear Medicine, Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Biother Radiopharm 18:301-16. 2003
    ..We have also learned that radiobiologic responses to Auger-electron emission are particularly sensitive to the site of decay, not only within the cell but also in the nucleus within the fine structure of chromatin...
  67. ncbi Radioguided surgery of primary hyperparathyroidism using the low-dose 99mTc-sestamibi protocol: multiinstitutional experience from the Italian Study Group on Radioguided Surgery and Immunoscintigraphy (GISCRIS)
    Domenico Rubello
    Nuclear Medicine Service, S Maria della Misericordia Hospital, Rovigo, Italy
    J Nucl Med 46:220-6. 2005
    ..The study was undertaken under the aegis of the Italian Study Group on Radioguided Surgery and Immunoscintigraphy (GISCRIS)...
  68. ncbi Long-term prognostic value of 18F-FDG PET in patients with locally advanced rectal cancer previously treated with neoadjuvant radiochemotherapy
    Carlo Capirci
    Radiotherapy Department, S Maria della Misericordia Hospital, Rovigo, Italy
    AJR Am J Roentgenol 187:W202-8. 2006
    ..The purpose of this study was to assess the prognostic value of (18)F-FDG PET performed at restaging in patients with locally advanced rectal cancer who previously underwent neoadjuvant radiochemotherapy...
  69. ncbi Minimally invasive radio-guided parathyroidectomy: long-term results with the 'low 99mTc-sestamibi protocol'
    Domenico Rubello
    Nuclear Medicine Service, S Maria della Misericordia Hospital, Rovigo, Italy
    Nucl Med Commun 27:709-13. 2006
    ....
  70. ncbi Role of 99mTc-sestamibi SPECT in accurate selection of primary hyperparathyroid patients for minimally invasive radio-guided surgery
    Domenico Rubello
    Nuclear Medicine Service PET Unit, S Maria della Misericordia Hospital, Istituto Oncologico Veneto, Viale Tre Martiri, 140, 45100 Rovigo, Italy
    Eur J Nucl Med Mol Imaging 33:1091-4. 2006
    ..The aim of this study was to evaluate the clinical role or (99m)Tc-sestamibi SPECT in selecting patients for this procedure...
  71. ncbi Minimally invasive radio-guided parathyroidectomy
    Domenico Rubello
    Nuclear Medicine Service PET Unit, Santa Maria della Misericordia Hospital, Istituto Oncologico Veneto IOV, Viale Tre Martiti, 140, 45100 Rovigo, Italy
    Biomed Pharmacother 60:134-8. 2006
    ..A low 1 mCi Sestamibi dose appears sufficient to perform MIRP. Patients with concomitant Sestamibi avid thyroid nodules should be excluded from MIRP...
  72. ncbi Receptor radionuclide therapy of tumors: a road from basic research to clinical applications
    Lisa Bodei
    European Institute of Oncology Milan, Italy
    J Nucl Med 47:375-7. 2006
  73. ncbi 11C-methionine PET/CT in 99mTc-sestamibi-negative hyperparathyroidism in patients with renal failure on chronic haemodialysis
    Domenico Rubello
    Nuclear Medicine Service, PET Unit, S Maria della Misericordia Hospital, Insituto Oncologico Veneto, IOV, Viale Tre Martiri, 140, 45100 Rovigo, Italy
    Eur J Nucl Med Mol Imaging 33:453-9. 2006
    ..The purpose of this study was to investigate the use of (11)C-methionine PET/CT to detect hyperfunctioning parathyroid glands in patients with renal failure on chronic haemodialysis who had (99m)Tc-sestamibi-negative HPT...
  74. ncbi Comparison between remnant and red-marrow absorbed dose in thyroid cancer patients submitted to 131I ablative therapy after rh-TSH stimulation versus hypothyroidism induced by L-thyroxine withdrawal
    Angela Vaiano
    U O Fisica Sanitaria, Azienda Ospedaliero Universitaria Pisana, Azienda Ospedaliero Universitaria Pisana ed Università di Pisa, Italy
    Nucl Med Commun 28:215-23. 2007
    ..In this paper the I remnant and red-marrow doses calculated in differentiated thyroid cancer (DTC) patients pre-treated with rh-TSH are compared to those calculated in patients in hypothyroidism induced by L-T4 withdrawal...
  75. ncbi Treatment of local and regional recurrences of differentiated thyroid cancer by radio-guided surgery with iodine-131
    Massimo Salvatori
    Institute of Nuclear Medicine, Policlinico Gemelli, Universita Cattolica del Sacro Cuore, Roma, Italy
    Nucl Med Rev Cent East Eur 9:119-24. 2006
    ..Day 7--post-surgery TxWBS was performed using the remaining radioactivity...
  76. ncbi Scintigraphic techniques in primary hyperparathyroidism: from pre-operative localisation to intra-operative imaging
    Domenico Rubello
    Service of Nuclear Medicine, S Maria della Misericordia Hospital, Viale Tre Martiti, 140, 45100, Rovigo, and Regional Center of Nuclear Medicine, University of Pisa, Italy
    Eur J Nucl Med Mol Imaging 34:926-33. 2007
    ..Fifty percent or more of newly diagnosed PHPT patients are asymptomatic, and there is debate among endocrinologists and endocrine surgeons about whether or not such patients should be treated...
  77. ncbi Radio-guided surgery of differentiated thyroid cancer using (131)I or 99mTc-Sestamibi
    Domenico Rubello
    Nucl Med Commun 27:1-4. 2006
    ....
  78. ncbi A new severity score index for phenotypic classification and evaluation of responses to treatment in type I Gaucher disease
    Maja Di Rocco
    Rare Disease Unit, II Division of Pediatrics, Gaslini Institute, Genova, Italy
    Haematologica 93:1211-8. 2008
    ..This variability in clinical response justifies the development of a severity score index to assess disease activity, stage and prognosis, and to quantify the effects of treatment...
  79. ncbi Sequential FDG-PET/CT reliably predicts response of locally advanced rectal cancer to neo-adjuvant chemo-radiation therapy
    Carlo Capirci
    Division of Radiotherapy, S Maria della Misericordia Hospital, Rovigo, Italy
    Eur J Nucl Med Mol Imaging 34:1583-93. 2007
    ..The aim of this study was to prospectively assess the value of sequential FDG-PET scans in predicting the response of locally advanced rectal cancer to neo-adjuvant CRT...
  80. ncbi Evidence-based recommendations for monitoring bone disease and the response to enzyme replacement therapy in Gaucher patients
    Stephan vom Dahl
    Department of Internal Medicine, St Franziskus Hospital, Cologne, Germany
    Curr Med Res Opin 22:1045-64. 2006
    ..Enzyme replacement therapy reverses many of the clinical signs of Gaucher bone disease but early assessment and treatment, and regular monitoring, are essential in optimising outcomes...
  81. ncbi Organic alternatives to quantum dots for intraoperative near-infrared fluorescent sentinel lymph node mapping
    Shunsuke Ohnishi
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Imaging 4:172-81. 2005
    ..This preclinical study, performed on large animals approaching the size of humans, should serve as a foundation for future clinical studies...
  82. ncbi Radioguided surgery of parathyroid adenomas and recurrent thyroid cancer using the "low sestamibi dose" protocol
    Domenico Rubello
    Nuclear Medicine Service, S Maria della Misericordia Hospital, Rovigo, Italy
    Cancer Biother Radiopharm 21:194-205. 2006
    ....
  83. ncbi The role of somatostatin in vasogenic meningioma associated brain edema
    Sabina Pistolesi
    Department of Surgery, University of Pisa, Italy
    Tumori 89:136-40. 2003
    ..58, P < 0.001) and between sst2 and vascular endothelial growth factor expression (P = 0.03). This suggests that somatostatin analogues may be relevant for the treatment of meningiomas...
  84. doi Assessment of tumor tissue oxygenation: agents, methods and clinical significance
    Ernest K J Pauwels
    Department of Radiological Sciences, Leiden University Medical Center, Leiden, The Netherlands
    Drug News Perspect 20:619-26. 2007
    ..This paper reviews the state-of-the-art in this field. In addition, this paper mentions the related research and new agents to target hypoxia-related makers to interfere with tumor survival and growth...
  85. ncbi Multidrug resistance in cancer: its mechanism and its modulation
    Ernest K J Pauwels
    Leiden University, The Netherlands
    Drug News Perspect 20:371-7. 2007
    ..However, in spite of considerable progress in research regarding multidrug resistance, the phase of efficacious clinical use of this knowledge has not been reached yet...
  86. ncbi Recombinant human thyroid-stimulating hormone is effective for radioiodine ablation of post-surgical thyroid remnants
    Daniele Barbaro
    Spedali Riuniti di Livorno, Italy
    Nucl Med Commun 27:627-32. 2006
    ..To investigate whether recombinant human thyroid-stimulating factor (rhTSH) is effective for the radiometabolic ablation of post-surgery thyroid remnants, using low doses of (131)I...
  87. ncbi Allergen biodistribution in humans
    Marcello Bagnasco
    Allergy and Clinical Immunology Unit, Department of Internal Medicine, Genoa University, Genoa, Italy
    Chem Immunol Allergy 82:33-43. 2003
    ..These data are potentially useful to improve immunotherapy treatment protocols by noninjectable routes...
  88. ncbi Procedure guideline for brain death scintigraphy
    Kevin J Donohoe
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Nucl Med 44:846-51. 2003