Rossella Marcucci

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. doi Gender and anti-thrombotic therapy: from biology to clinical implications
    Rossella Marcucci
    Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50050, Florence, Italy
    J Cardiovasc Transl Res 7:72-81. 2014
  2. doi Reticulated platelets predict cardiovascular death in acute coronary syndrome patients. Insights from the AMI-Florence 2 Study
    F Cesari
    Department of Clinical and Experimental Medicine, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Largo Brambilla 3, Florence, Italy
    Thromb Haemost 109:846-53. 2013
  3. doi High on-treatment platelet reactivity by ADP and increased risk of MACE in good clopidogrel metabolizers
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Viale Morgagni 85, Florence, Italy
    Platelets 23:586-93. 2012
  4. doi Antiplatelets in acute coronary syndrome: personal perspectives
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Expert Rev Cardiovasc Ther 10:1487-96. 2012
  5. doi High on-treatment platelet reactivity by more than one agonist predicts 12-month follow-up cardiovascular death and non-fatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Thromb Haemost 104:279-86. 2010
  6. doi Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up
    Rossella Marcucci
    Department of Medical and Surgical Critical Care and Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Circulation 119:237-42. 2009
  7. ncbi ADAMTS-13 activity in the presence of elevated von Willebrand factor levels as a novel mechanism of residual platelet reactivity in high risk coronary patients on antiplatelet treatment
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Thromb Res 123:130-6. 2008
  8. ncbi Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function
    Anna Maria Gori
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Thromb Haemost 100:1136-45. 2008
  9. doi High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI
    Guido Parodi
    Department of Cardiology, Careggi Hospital, Florence, Italy
    JAMA 306:1215-23. 2011
  10. doi Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients
    Rita Paniccia
    Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Florence, Italy
    Thromb Haemost 104:287-92. 2010

Collaborators

Detail Information

Publications73

  1. doi Gender and anti-thrombotic therapy: from biology to clinical implications
    Rossella Marcucci
    Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50050, Florence, Italy
    J Cardiovasc Transl Res 7:72-81. 2014
    ..In summary, there are some gender-related aspects of guidance in the complex spectrum of the net clinical benefit related to antithrombotic treatment. ..
  2. doi Reticulated platelets predict cardiovascular death in acute coronary syndrome patients. Insights from the AMI-Florence 2 Study
    F Cesari
    Department of Clinical and Experimental Medicine, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Largo Brambilla 3, Florence, Italy
    Thromb Haemost 109:846-53. 2013
    ..Future prospective studies to evaluate the role of RP in determining cardiovascular events are warranted...
  3. doi High on-treatment platelet reactivity by ADP and increased risk of MACE in good clopidogrel metabolizers
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Viale Morgagni 85, Florence, Italy
    Platelets 23:586-93. 2012
    ..Therefore, both phenotype and genotype are clinically relevant for the evaluation of the antiplatelet effect of clopidogrel and for the prognostic stratification of ACS patients...
  4. doi Antiplatelets in acute coronary syndrome: personal perspectives
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Expert Rev Cardiovasc Ther 10:1487-96. 2012
    ....
  5. doi High on-treatment platelet reactivity by more than one agonist predicts 12-month follow-up cardiovascular death and non-fatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Thromb Haemost 104:279-86. 2010
    ..Isolated platelet hyperreactivity to only one agonist has not a predictive value for clinical recurrences...
  6. doi Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up
    Rossella Marcucci
    Department of Medical and Surgical Critical Care and Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Circulation 119:237-42. 2009
    ....
  7. ncbi ADAMTS-13 activity in the presence of elevated von Willebrand factor levels as a novel mechanism of residual platelet reactivity in high risk coronary patients on antiplatelet treatment
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Thromb Res 123:130-6. 2008
    ..In the acute phase of coronary artery disease large amounts of ultra large VWF multimers (ULVWF) are released and cleaved by the activity of ADAMTS-13...
  8. ncbi Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function
    Anna Maria Gori
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Thromb Haemost 100:1136-45. 2008
    ..This prospective study documents that the evaluation of platelet reactivity addressed to identify patients at risk of thrombotic events on dual antiplatelet treatment has to be carried out by methods able to explore different pathways...
  9. doi High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI
    Guido Parodi
    Department of Cardiology, Careggi Hospital, Florence, Italy
    JAMA 306:1215-23. 2011
    ..High residual platelet reactivity (HRPR) in patients receiving clopidogrel has been associated with high risk of ischemic events after percutaneous coronary intervention (PCI)...
  10. doi Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients
    Rita Paniccia
    Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Florence, Italy
    Thromb Haemost 104:287-92. 2010
    ..MEA might represent a reliable method and valid alternative in comparison with other available platelet function assays. It might help to guide antiplatelet therapy and thus improve clinical outcome of high-risk CAD patients...
  11. ncbi Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Am J Cardiol 103:806-11. 2009
    ..These findings could impact on the future design of pharmacogenetic antiaggregant strategies...
  12. pmc Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility
    Betti Giusti
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    PLoS ONE 2:e495. 2007
    ..Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF...
  13. ncbi Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients
    Lucia Mannini
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
    Clin Hemorheol Microcirc 35:175-81. 2006
    ....
  14. ncbi Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Atherosclerosis 198:223-7. 2008
    ..In conclusion, the present study documents, on a large sample of patients, that low vitamin B6 levels, low folic acid levels and elevated Hcy levels are each independently associated with RVO...
  15. ncbi Comparison of the degree of platelet aggregation inhibition with prasugrel versus clopidogrel and clinical outcomes in patients with unprotected left main disease treated with everolimus-eluting stents
    Angela Migliorini
    Department of Cardiology, Careggi Hospital, Florence, Italy
    Am J Cardiol 112:1843-8. 2013
    ..17; 95% confidence interval 0.04 to 0.77, p = 0.022). In conclusion, in patients treated with EES for ULMD, prasugrel compared with clopidogrel is associated with increased platelet aggregation inhibition and a better clinical outcome. ..
  16. ncbi Usefulness of aspirin resistance after percutaneous coronary intervention for acute myocardial infarction in predicting one-year major adverse coronary events
    Rossella Marcucci
    Department of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
    Am J Cardiol 98:1156-9. 2006
    ..9, 95% confidence interval 1.1 to 9.2, p <0.05). In conclusion, our data demonstrate that aspirin resistance after PCI is a significant and independent predictor of MACEs in patients with AMI undergoing primary PCI...
  17. ncbi Atherosclerotic and thrombophilic risk factors in patients with ischemic central retinal vein occlusion
    Andrea Sodi
    Eye Clinic, University of Florence, Florence, Italy
    Retina 31:724-9. 2011
    ..To investigate atherosclerotic and thrombophilic risk factors in patients affected by acute ischemic and nonischemic central retinal vein occlusions (CRVOs)...
  18. ncbi Role of haemorheological factors in patients with retinal vein occlusion
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Thromb Haemost 98:1215-9. 2007
    ..In conclusion, our data indicate that an alteration of haemorheological parameters may modulate the susceptibility to the RVO, by possibly helping to identify patients who may benefit from haemodilution...
  19. ncbi Comparison of different methods to evaluate the effect of aspirin on platelet function in high-risk patients with ischemic heart disease receiving dual antiplatelet treatment
    Rita Paniccia
    Department of Medical and Surgical Critical Care, Thrombosis Center, Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Italy
    Am J Clin Pathol 128:143-9. 2007
    ..0001). Assuming LTA as the reference method, PFA-100 and VerifyNow showed sensitivity of 62.1% and 39.3% and specificity of 80.2% and 96.4%, respectively. The cutoff values for POC methods need to be defined for clinical use...
  20. ncbi Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis
    Piergiovanni Buonamici
    Department of Cardiology, Careggi Hospital, Florence, Italy
    J Am Coll Cardiol 49:2312-7. 2007
    ..We sought to determine whether nonresponsiveness to clopidogrel as revealed by high in vitro post-treatment platelet reactivity is predictive of drug-eluting stent (DES) thrombosis...
  21. doi Evaluation of traditional and emerging cardiovascular risk factors in patients with non-arteritic anterior ischemic optic neuropathy: a case-control study
    Barbara Giambene
    Eye Clinic, University of Florence, Viale Morgagni, 85 50134, Florence, Italy
    Graefes Arch Clin Exp Ophthalmol 247:693-7. 2009
    ..This study aims at evaluating the role of traditional and emerging cardiovascular risk factors on the development of NAION...
  22. ncbi Relationship between high platelet turnover and platelet function in high-risk patients with coronary artery disease on dual antiplatelet therapy
    Francesca Cesari
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Thromb Haemost 99:930-5. 2008
    ..This study indicates that a high rate of platelet turnover is a new mechanism associated with platelet reactivity in high risk CAD patients on dual antiplatelet therapy...
  23. ncbi Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Pharmacogenet Genomics 17:1057-64. 2007
    ....
  24. ncbi Cardiovascular and thrombophilic risk factors in patients with retinal artery occlusion
    Rossella Marcucci
    Department of Heart and Vessels, Thrombosis Center, Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Blood Coagul Fibrinolysis 18:321-6. 2007
    ..Our findings may have implications for the management of these patients, suggesting the need for an intensive and tailored secondary prevention and new therapeutic approaches...
  25. ncbi Lone and secondary nonvalvular atrial fibrillation: role of a genetic susceptibility
    Cinzia Fatini
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Int J Cardiol 120:59-65. 2007
    ..The aim of this study was to investigate the role of the ACE I/D polymorphism in relation to the different clinical forms of AF, lone and secondary nonvalvular atrial fibrillation (NVAF)...
  26. doi Effect of blood hematocrit and erythrocyte deformability on adenosine 5'-diphosphate platelet reactivity in patients with acute coronary syndromes on dual antiplatelet therapy
    Emanuele Cecchi
    Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Am J Cardiol 104:764-8. 2009
    ..In conclusion, these results demonstrate the influence of hematocrit and of erythrocyte deformability on ADP platelet reactivity. These variables could be considered to optimize treatment with antiplatelet therapy in these patients...
  27. doi Light transmittance aggregometry induced by different concentrations of adenosine diphosphate to monitor clopidogrel therapy: a methodological study
    Rita Paniccia
    Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Florence, Italy
    Ther Drug Monit 33:94-8. 2011
    ..This suggests that a concentration of 10 μmol/L ADP may be considered adequate for the identification of RPR of patients on clopidogrel and should be preferred for standardization LTA...
  28. doi Comparison of prasugrel and ticagrelor loading doses in ST-segment elevation myocardial infarction patients: RAPID (Rapid Activity of Platelet Inhibitor Drugs) primary PCI study
    Guido Parodi
    Department of Cardiology, Careggi Hospital, Florence, Italy
    J Am Coll Cardiol 61:1601-6. 2013
    ..This study sought to compare the action of prasugrel and ticagrelor in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI)...
  29. ncbi Culprit factors for the failure of well-conducted warfarin therapy to prevent ischemic events in patients with atrial fibrillation: the role of homocysteine
    Daniela Poli
    Department of Critical Care Medicine, Thrombosis Centre, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
    Stroke 36:2159-63. 2005
    ..In this study, we prospectively investigated the role of classic risk factors and homocysteine levels in the occurrence of ischemic complications in 364 AF patients on OAT...
  30. doi The thrombophilic pattern of different clinical manifestations of venous thromboembolism: a survey of 443 cases of venous thromboembolism
    Elisa Grifoni
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Semin Thromb Hemost 38:230-4. 2012
    ..In conclusion, the thrombophilic burden seems different in isolated PE versus DVT with or without PE, suggesting that PE may encompass a different pathophysiological process of thrombosis to DVT...
  31. ncbi eNOS gene influences platelet phenotype in acute coronary syndrome patients on dual antiplatelet treatment
    Cinzia Fatini
    Department of Medical and Surgical Critical Care, Department of Heart and Vessels, Azienda Ospedaliero Universitaria Careggi, University of Florence, 50134 Florence, Italy
    Platelets 20:548-54. 2009
    ..02). This study evidences a role for eNOS gene in moderately, but significantly, modulating platelet phenotype in a high-risk population on dual antiplatelet treatment...
  32. ncbi Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy
    Rossella Marcucci
    Department of Heart and Vessels, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy
    Atherosclerosis 195:e217-23. 2007
    ..These results provide indications for the selection of patients for whom the evaluation of platelet reactivity could be useful...
  33. ncbi Platelet and leukocyte ROS production and lipoperoxidation are associated with high platelet reactivity in Non-ST elevation myocardial infarction (NSTEMI) patients on dual antiplatelet treatment
    Matteo Becatti
    Department of Experimental and Clinical Medicine, University of Florence, Italy Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
    Atherosclerosis 231:392-400. 2013
    ..Several studies have shown that reactive oxygen species (ROS) may be involved in modulating platelet function...
  34. ncbi Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment
    Betti Giusti
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Atherosclerosis 196:341-8. 2008
    ....
  35. ncbi Clopidogrel non-responsiveness and risk of cardiovascular morbidity. An updated meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Thromb Haemost 103:841-8. 2010
    ....
  36. doi High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Biochem Genet 46:406-23. 2008
    ..2% concordance. We also performed a haplotype analysis. This approach could represent a useful tool to investigate the genotype-phenotype correlation and the association of these genes with hyperhomocysteinemia and correlated diseases...
  37. ncbi Relationship between exercise capacity, endothelial progenitor cells and cytochemokines in patients undergoing cardiac rehabilitation
    Francesca Cesari
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Thromb Haemost 101:521-6. 2009
    ..Finally, CD34+/KDR+ EPCs showed significant correlation with IL-8 at T1. In conclusion, a short period of CR intervention determines a different pattern of modifications for EPCs in relation to the improvement of exercise capacity...
  38. ncbi Protein Z levels and prognosis in patients with acute coronary syndromes
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Florence, Italy
    Clin Chem Lab Med 44:1098-102. 2006
    ..The aims of this study were to test changes in protein Z and their association with outcome at 1-year follow-up in 193 (150 male, 43 female) patients with ACS...
  39. ncbi Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents
    Anna Maria Gori
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    J Am Coll Cardiol 52:734-9. 2008
    ..This study sought to determine the incidence of aspirin nonresponsiveness in addition to clopidogrel nonresponsiveness and whether this association identifies patients at an increased risk of drug-eluting stent (DES) thrombosis...
  40. doi High lipoprotein (a) levels are associated with an increased risk of retinal vein occlusion
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Atherosclerosis 210:278-81. 2010
    ..The aim of this study was to investigate, in a large group of RVO patients, the role of such an emerging thrombophilic parameter on the pathogenesis of RVO...
  41. ncbi Residual platelet reactivity on aspirin therapy and recurrent cardiovascular events--a meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Int J Cardiol 128:166-71. 2008
    ..The aim of this study was to systematically assess the relationship between RPR on acetylic salicylic acid (ASA) therapy and the occurrence of recurrent events in a meta-analysis of prospective studies...
  42. doi The quality of anticoagulation on functional outcome and mortality for TIA/stroke in atrial fibrillation patients
    Daniela Poli
    Department of Medical and Surgical Critical Care, Thrombosis Centre, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
    Int J Cardiol 132:109-13. 2009
    ..However, fluctuation of anticoagulation levels is intrinsically related to OAT and often international normalized ratio (INR) is out of the therapeutic range...
  43. ncbi Impaired fibrinolysis in retinal vein occlusion: a role for genetic determinants of PAI-1 levels
    Anna Maria Gori
    Department of Surgical and Medical Critical Care, Thrombosis Center, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy
    Thromb Haemost 92:54-60. 2004
    ....
  44. ncbi Hyperhomocysteinemia and vitamin B6 deficiency: new risk markers for nonvalvular atrial fibrillation?
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence Italy
    Am Heart J 148:456-61. 2004
    ..Furthermore, the role of these variables in the occurrence of ischemic events was investigated...
  45. ncbi High residual platelet reactivity after clopidogrel loading and long-term clinical outcome after drug-eluting stenting for unprotected left main coronary disease
    Angela Migliorini
    Department of Heart and Vessels, University of Florence, Careggi Hospital, 50134 Florence, Italy
    Circulation 120:2214-21. 2009
    ..No data exist about the impact of high residual platelet reactivity (HRPR) after clopidogrel loading on long-term clinical outcome in patients undergoing drug-eluting stent (DES) implantation for unprotected left main disease (ULMD)...
  46. doi Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy
    Rita Paniccia
    Departments of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Italy
    Am J Clin Pathol 131:834-42. 2009
    ..0001 for all). Multiplate IPA might represent a reliable, handy, rapid tool to monitor antiplatelet therapy in clinical practice and for clinical investigations...
  47. ncbi ACE insertion/deletion, but not -240A>T polymorphism, modulates the severity in heart failure
    Cinzia Fatini
    Department of Medical and Surgical Critical Care, Thrombosis Centre and Centre for the Study at Molecular and Clinical Level of Chronic, University of Florence, Italy
    J Investig Med 56:1004-10. 2008
    ..In this study, we investigated the role of ACE I/D and -240A>T polymorphisms in influencing both severity and clinical outcomes in patients with heart failure, according to New York Heart Association (NYHA) class...
  48. ncbi Risk of bleeding in very old atrial fibrillation patients on warfarin: relationship with ageing and CHADS2 score
    Daniela Poli
    Department of Critical Care Medicine, Thrombosis Centre, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
    Thromb Res 121:347-52. 2007
    ..In atrial fibrillation (AF) patients, age >or=75 years is one of the major risk factors for stroke. However, it is not clear if an upper limit for the indication to OAT exists...
  49. ncbi A hypercoagulable and hypofibrinolytic state is detectable by global methods in patients with retinal vein occlusion
    Anna Paola Cellai
    Thrombosis Centre, Department of Heart and Vessels, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Atherosclerosis 224:97-101. 2012
    ..Further studies should assess the possible clinical value of our data in the management of RVO patients...
  50. ncbi Hyperhomocysteinemia in patients with pulmonary embolism is associated with impaired plasma fibrinolytic capacity
    Anna Paola Cellai
    Department of Heart and Vessels, Thrombosis Centre, Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy
    J Thromb Thrombolysis 38:45-9. 2014
    ..0 95% CI 1.6-15.9; p = 0.006) resulted independently associated with impaired fibrinolytic activity. HHcy affects TAFI-mediated hypofibrinolysis but not fibrin(ogen) structure or function as documented by fibrin degradation analysis...
  51. doi Impact of a cardiac rehabilitation program and inflammatory state on endothelial progenitor cells in acute coronary syndrome patients
    Francesca Cesari
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Int J Cardiol 167:1854-9. 2013
    ..However not all patients respond to CR with an increase of EPC. We performed this study to identify the characteristics of patients who will not benefit from an increase of EPCs at the end of a CR program...
  52. ncbi Hyperviscosity as a possible risk factor for cerebral ischemic complications in atrial fibrillation patients
    Emanuele Cecchi
    Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy
    Am J Cardiol 97:1745-8. 2006
    ..These results should stimulate prospective studies on the role of hemorheologic alterations in the occurrence of cerebral ischemic complications in patients with AF...
  53. pmc Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis
    Maria Rosa Biagini
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgagni 85 50134, Firenze, Italy
    World J Gastroenterol 12:1607-12. 2006
    ..To assess the hypercoagulability in PBC and its relationship with homocysteine (HCY) and various components of the haemostatic system...
  54. ncbi Clinical haemorheology and microcirculation
    Lucia Mannini
    Dipartimento di Area Critica Medico Chirurgica, Sez Clinica Medica Generale e Cliniche Specialistiche, Centro Trombosi, Universita di Firenze, Viale Morgagni 85, 50134 Firenze, Italy
    Ann Ist Super Sanita 43:144-55. 2007
    ..These results suggest that hyperviscosity, either determined by genetic susceptibility or not, can be involved in the pathophysiology of these clinical disorders and can be the target of new therapeutic strategies...
  55. ncbi Lifestyle modifications after acute coronary syndromes in a subset of the AMI-Florence 2 Registry
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    Acta Cardiol 66:791-6. 2011
    ..The aim of this study was to evaluate the adherence to recommendations for secondary prevention of cardiovascular diseases in patients with acute coronary syndromes (ACS)...
  56. ncbi Endothelial nitric oxide synthase -786T>C, but not 894G>T and 4a4b, polymorphism influences plasma homocysteine concentrations in persons with normal vitamin status
    Cinzia Fatini
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Clin Chem 51:1159-64. 2005
    ..The aim of this study was to investigate the role of endothelial nitric oxide synthase (eNOS) -786T>C, 894G>T, and 4a4b polymorphisms in influencing Hcy concentrations...
  57. ncbi Thrombophilic risk factors for symptomatic peripheral arterial disease
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    J Vasc Surg 41:255-60. 2005
    ..The aim of this study was to determine an extended thrombophilic risk profile of patients with symptomatic PAD...
  58. ncbi High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-1 are present in patients with abdominal aortic aneurysm
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Thromb Haemost 94:1094-8. 2005
    ..13; p = 0.005). In conclusion, a significant association between abnormal levels of some metabolic parameters related to thrombosis such as Hcy, Lp(a) and PAI-1 and AAA has been observed...
  59. doi High platelet turnover and reactivity in renal transplant recipients patients
    Francesca Cesari
    Department of Medical and Surgical Critical Care, Thrombosis Centre, Center for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Italy
    Thromb Haemost 104:804-10. 2010
    ..With regard to vWF, RTRs patients showed higher levels than control subjects. We documented a higher platelet turn-over in both groups of RTRs patients and increased platelet reactivity in RTRs patients not on ASA therapy than controls...
  60. doi S38G single-nucleotide polymorphism at the KCNE1 locus is associated with heart failure
    Cinzia Fatini
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Heart Rhythm 7:363-7. 2010
    ..Experimental data demonstrated a higher KCNE1 expression in heart failure (HF)...
  61. doi Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis
    Betti Giusti
    University of Florence and SOD Atherothrombotic Diseases, Department of Medical and Surgical Critical Care, AOU Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Expert Opin Drug Metab Toxicol 6:393-407. 2010
    ..Recently, CYP2C19*2 polymorphism (G681A nucleotide substitution) has been shown to be associated with decreased metabolisation of clopidogrel, poor antiaggregant effect and increased adverse cardiovascular events...
  62. ncbi Increased plasma levels of lipoprotein(a) and the risk of idiopathic and recurrent venous thromboembolism
    Rossella Marcucci
    Dipartimento Area Critica Medico Chirurgica, Clinica Medica Generale e Cardiologia, Florence, Italy
    Am J Med 115:601-5. 2003
    ..Elevated lipoprotein(a) [Lp(a)] levels are a recognized risk factor for cardiovascular disease; however, little is known about their effects on venous thromboembolism...
  63. ncbi Lipoprotein (a) and venous thromboembolism in adults: a meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    Am J Med 120:728-33. 2007
    ..The aim of this article is to systematically examine the published data on the association between high Lp(a) levels and venous thromboembolism...
  64. ncbi Adherence to a healthful life attenuates lipid parameters among a healthy Italian population
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Nutr Metab Cardiovasc Dis 17:642-8. 2007
    ....
  65. doi Diabetes and sex: from pathophysiology to personalized medicine
    Rosanna Abbate
    Department of Medical and Surgical Critical Care, University of Florence, SOD Atherothrombotic Diseases, AOU Careggi, Viale Morgagni, 85, 50134, Florence, Italy
    Intern Emerg Med 7:S215-9. 2012
    ..In relation to diabetes, the sex-related difference in platelet activity and platelet inhibitory response to anti-aggregating therapy, reported in the general population, was observed also in diabetic women...
  66. ncbi Association between homocysteine, vitamin B(6) concentrations and inflammation
    Anna Maria Gori
    Department of Medical and Surgical Critical Care, University of Florence, DeNOTHE Centre for the Study at Molecular and Clinical Level of Chronic, University of Florence, Florence, Italy
    Clin Chem Lab Med 45:1728-36. 2007
    ..This association, independent of the leading factor, may explain, at least in part, why subjects with high concentrations of Hcy and low concentrations of vitamin B(6) have a high risk of developing cardiovascular diseases...
  67. ncbi TAFI activity and antigen plasma levels are not increased in acute coronary artery disease patients admitted to a coronary care unit
    Anna Paola Cellai
    Department of Medical and Surgical Critical Care, Thrombosis Centre, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
    Thromb Res 118:495-500. 2006
    ..There are contradictory results regarding TAFI levels in CAD patients, possibly because the characteristics of patients investigated and the time of blood sampling were different among different studies...
  68. ncbi NT-proBNP and the anti-inflammatory cytokines are correlated with endothelial progenitor cells' response to cardiac surgery
    Francesca Cesari
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Atherosclerosis 199:138-46. 2008
    ..We used cardiac surgery as a model of acute inflammatory response to evaluate the role of the inflammatory mediators in influencing the number of circulating endothelial progenitor cells (EPCs)...
  69. doi Retinal vein occlusions: a review for the internist
    Rossella Marcucci
    Department of Medical and Surgical Critical Area, University of Florence, Florence, Italy
    Intern Emerg Med 6:307-14. 2011
    ..No data are available on the possible role of antithrombotic strategies in the long-term prevention of recurrent RVO or vascular events...
  70. pmc Determinants to optimize response to clopidogrel in acute coronary syndrome
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, SOD Atherothrombotic Diseases, AOU Careggi, Florence, Italy
    Pharmgenomics Pers Med 3:33-50. 2010
    ....
  71. ncbi Retinal vein thrombosis: risk factors, pathogenesis and therapeutic approach
    Domenico Prisco
    Department of Medical and Surgical Critical Area, Section of Clinica Medica Generale e Cliniche Specialistiche, University of Florence, Florence, Italy
    Pathophysiol Haemost Thromb 32:308-11. 2002
    ..However, the approach to CRVO treatment with antithrombotic drugs is not evidence-based yet. There is urgent need of intervention trials to evaluate the role of these drugs in CRVO patients...
  72. ncbi Genetic determinants of fasting and post-methionine hyperhomocysteinemia in patients with retinal vein occlusion
    Rossella Marcucci
    Dipartimento di Area Critica Medico Chirurgica, Sez di Clinica Medica Generale e Cliniche Specialistiche, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy
    Thromb Res 110:7-12. 2003
    ..Moreover, scarce information is available on the usefulness of measuring homocysteine also after methionine loading to increase the diagnostic efficacy of hyperhomocysteinemia in RVO patients...
  73. ncbi Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients
    Rossella Marcucci
    Surgical and Medical Critical Care, Clinica Medica Generale e Cliniche Specialistiche, University of Florence, Italy
    Transplantation 75:1551-5. 2003
    ..The purpose of our study was to document, in hyperhomocysteinemic RTRs, the effect of vitamin supplementation on carotid intima-media thickness (cIMT), which is an early sign of atherosclerosis...