Claudio Marcocci

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint Long-term safety of orbital radiotherapy for Graves' ophthalmopathy
    Claudio Marcocci
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:3561-6. 2003
  2. ncbi request reprint A treatment strategy for Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Nat Clin Pract Endocrinol Metab 3:430-6. 2007
  3. ncbi request reprint Fluoride and anabolic steroids in the treatment of glucocorticoid-induced osteoporosis
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia e Medicina del Lavoro, Universita di Pisa, Pisa, Italia
    Front Horm Res 30:165-73. 2002
  4. ncbi request reprint Novel aspects of immunosuppressive and radiotherapy management of Graves' ophthalmopathy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:272-80. 2004
  5. ncbi request reprint Current medical management of Graves ophthalmopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Ophthal Plast Reconstr Surg 18:402-8. 2002
  6. ncbi request reprint Graves' ophthalmopathy and 131I therapy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Q J Nucl Med 43:307-12. 1999
  7. pmc Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 94:2766-72. 2009
  8. ncbi request reprint The course of Graves' ophthalmopathy is not influenced by near total thyroidectomy: a case-control study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Pisa, Italy
    Clin Endocrinol (Oxf) 51:503-8. 1999
  9. doi request reprint Identification and functional characterization of loss-of-function mutations of the calcium-sensing receptor in four Italian kindreds with familial hypocalciuric hypercalcemia
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 160:481-9. 2009
  10. ncbi request reprint TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells
    Roberta Botta
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy
    Thyroid 16:1097-104. 2006

Detail Information

Publications86

  1. ncbi request reprint Long-term safety of orbital radiotherapy for Graves' ophthalmopathy
    Claudio Marcocci
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:3561-6. 2003
    ..Although no secondary tumors were detected, due to the long latency of radiation-induced tumors, OR should be restricted to patients older than 35 yr...
  2. ncbi request reprint A treatment strategy for Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Nat Clin Pract Endocrinol Metab 3:430-6. 2007
    ..After glucocorticoid withdrawal, however, the patient's eye motility worsened and there was a reduction of visual acuity in the left eye. She was then referred to our hospital for further advice and treatment...
  3. ncbi request reprint Fluoride and anabolic steroids in the treatment of glucocorticoid-induced osteoporosis
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia e Medicina del Lavoro, Universita di Pisa, Pisa, Italia
    Front Horm Res 30:165-73. 2002
  4. ncbi request reprint Novel aspects of immunosuppressive and radiotherapy management of Graves' ophthalmopathy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:272-80. 2004
    ..New data on recently performed placebo-controlled studies on orbital radiotherapy are discussed, together with studies on long-term safety of orbital radiotherapy...
  5. ncbi request reprint Current medical management of Graves ophthalmopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Ophthal Plast Reconstr Surg 18:402-8. 2002
  6. ncbi request reprint Graves' ophthalmopathy and 131I therapy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Q J Nucl Med 43:307-12. 1999
    ..Glucocorticoid treatment should be limited, in our opinion, to patients with clinically evident eye disease and to those without ophthalmopathy but with other known risk factors, such as smoking...
  7. pmc Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 94:2766-72. 2009
    ..Patients with persistent primary hyperparathyroidism (PHPT) after parathyroidectomy or with contraindications to parathyroidectomy often require chronic treatment for hypercalcemia...
  8. ncbi request reprint The course of Graves' ophthalmopathy is not influenced by near total thyroidectomy: a case-control study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Pisa, Italy
    Clin Endocrinol (Oxf) 51:503-8. 1999
    ..Although controversial, radioiodine may be followed by progression of eye disease, preventable by glucocorticoid administration. Whether thyroidectomy affects the course of ophthalmopathy is uncertain...
  9. doi request reprint Identification and functional characterization of loss-of-function mutations of the calcium-sensing receptor in four Italian kindreds with familial hypocalciuric hypercalcemia
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 160:481-9. 2009
    ..Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia...
  10. ncbi request reprint TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells
    Roberta Botta
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy
    Thyroid 16:1097-104. 2006
    ..Based on these findings, we concluded that RAP is expressed by thyrocytes in a TSH-dependent manner, both in cultured thyroid cells and in vivo...
  11. ncbi request reprint Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 156:547-54. 2007
    ..The aim of our study was to extend parafibromin studies in a series of benign and malignant parathyroid tumors and cross-validate the results of immunohistochemistry with those of HRPT2 analysis...
  12. ncbi request reprint Genetic analyses in familial isolated hyperparathyroidism: implication for clinical assessment and surgical management
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 64:146-52. 2006
    ..Design Genetic analyses of MEN1, HRPT2 and CASR genes in FIHP...
  13. ncbi request reprint Improvement of growth hormone deficiency in patients with primary hyperparathyroidism after parathyroidectomy: results of a prospective study
    Elisabetta Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:1213-6. 2004
    ..Accordingly, GH deficiency in PHP patients must be considered a functional phenomenon for which GH therapy is not recommended...
  14. ncbi request reprint Effects of total thyroid ablation versus near-total thyroidectomy alone on mild to moderate Graves' orbitopathy treated with intravenous glucocorticoids
    Francesca Menconi
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1653-8. 2007
    ..Total thyroid ablation (TTA) may be beneficial for GO through removal of shared antigen(s) and autoreactive T-lymphocytes, but randomized studies are lacking...
  15. ncbi request reprint Thyroid dysfunction in megalin deficient mice
    Simonetta Lisi
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Mol Cell Endocrinol 236:43-7. 2005
    ..Although the serological phenotype in megalin-/- mice was not associated with histological alterations or goiter, our results support a major role of megalin in thyroid hormone secretion...
  16. doi request reprint Sortilin is a putative postendocytic receptor of thyroglobulin
    Roberta Botta
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy
    Endocrinology 150:509-18. 2009
    ..Our findings provide a novel pathway of Tg trafficking and a novel function of sortilin in the thyroid gland, the functional impact of which remains to be established...
  17. doi request reprint Enalapril reduces proliferation and hyaluronic acid release in orbital fibroblasts
    Roberta Botta
    Endocrinology, University of Pisa, Pisa, Italy
    Thyroid 23:92-6. 2013
    ....
  18. ncbi request reprint The reduction of bone mineral density in postmenopausal women with primary hyperparathyroidism is higher in the presence of concomitant GH secretion impairment
    Elisabetta Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Ospedale, Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 155:41-5. 2006
    ..To investigate, in a large group of postmenopausal primary hyperparathyroidism (PHP) women, whether the concomitance of GH deficiency (GHD) may contribute to the development of changes in bone mineral density (BMD)...
  19. ncbi request reprint Surgery or surveillance for mild asymptomatic primary hyperparathyroidism: a prospective, randomized clinical trial
    Elena Ambrogini
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 92:3114-21. 2007
    ..It is unclear whether patients with asymptomatic primary hyperparathyroidism (PHPT) do better with parathyroidectomy (PTx) as compared with conservative medical management...
  20. ncbi request reprint Orbital decompression in graves' ophthalmopathy by medial and lateral wall removal
    Stefano Sellari-Franceschini
    Department of Neuroscience, Ia ENT division, Pisa, Italy
    Otolaryngol Head Neck Surg 133:185-9. 2005
    ..The objective of this study is to describe a technique for balanced orbital decompression and to analyze the results...
  21. doi request reprint Aryl hydrocarbon receptor interacting protein (AIP) mutations occur rarely in sporadic parathyroid adenomas
    Elena Pardi
    Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 98:2800-10. 2013
    ..The molecular pathogenesis of primary hyperparathyroidism is still largely unknown. The aryl hydrocarbon receptor interacting protein (AIP) gene has a major role in the pathogenesis of familial isolated pituitary adenoma...
  22. doi request reprint Thyroid volume and severity of Graves' orbitopathy
    Maria Antonietta Profilo
    Endocrinology Unit, University Hospital of Pisa, Pisa, Italy
    Thyroid 23:97-102. 2013
    ..Thus, we evaluated retrospectively whether there is a correlation between the degree of GO at its first observation and, among other parameters, the thyroid volume...
  23. doi request reprint Rehabilitative orbital decompression for Graves' orbitopathy: risk factors influencing the new onset of diplopia in primary gaze, outcome, and patients' satisfaction
    Roberto Rocchi
    Unit of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Thyroid 22:1170-5. 2012
    ..Moreover, we investigated the results in terms of proptosis reduction, and the long-term subjective satisfaction of patients treated with OD with regard to their appearance and ocular function...
  24. pmc Morphometric vertebral fractures in postmenopausal women with primary hyperparathyroidism
    Edda Vignali
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 94:2306-12. 2009
    ..An increased risk of fracture in patients with primary hyperparathyroidism (PHPT) compared to the general population has been reported, but available data are controversial...
  25. ncbi request reprint Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5583-91. 2004
    ..The finding that two of the seven patients with sporadic parathyroid cancer carried an HRPT2 germline mutation suggests that they might have occult HPT-JT. Our results also confirm the need for testing HRPT2 gene in FIHP families...
  26. pmc Spontaneous improvement of untreated mild graves' ophthalmopathy: Rundle's curve revisited
    Francesca Menconi
    1 Endocrinology, University Hospital of Pisa, Pisa, Italy
    Thyroid 24:60-6. 2014
    ..To our knowledge, no studies have tried to replicate Rundle's curve, and very few have investigated the natural history of GO. Here, we studied GO natural history retrospectively and tried to identify factors that may affect it...
  27. pmc Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release
    Simonetta Lisi
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Proc Natl Acad Sci U S A 100:14858-63. 2003
    ..Our study points to a major role of megalin in thyroid homeostasis with possible implications in thyroid diseases...
  28. ncbi request reprint Glycosaminoglycans provide a binding site for thyroglobulin in orbital tissues of patients with thyroid-associated ophthalmopathy
    Michele Marino
    Department of Endocrinology, University of Pisa, Pisa, Italy
    Thyroid 13:851-9. 2003
    ..Therefore, we conclude that GAGs provide binding sites for Tg in orbital tissues, which may explain the presence of Tg in orbital tissues of patients with TAO...
  29. ncbi request reprint Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice
    Simonetta Lisi
    Department of Endocrinology, University of Pisa, Via Paradisa 2, I 56124 Pisa, Italy
    Am J Physiol Cell Physiol 290:C1160-7. 2006
    ..In conclusion, RAP is required for the establishment of Tg reservoirs, but its absence does not affect hormone secretion...
  30. ncbi request reprint Management of thyroid eye disease
    Luigi Bartalena
    Department of Endocrinology, University of Insubria, Ospedale di Circolo, Viale Borri, 57, 21100 Varese, Italy
    Eur J Nucl Med Mol Imaging 29:S458-65. 2002
    ..A coordinated approach to the treatment of hyperthyroidism and TED is also required. Novel promising treatments, to be verified in large series of patients, include somatostatin analogues and cytokine antagonists...
  31. doi request reprint Outcome of Graves' orbitopathy after total thyroid ablation and glucocorticoid treatment: follow-up of a randomized clinical trial
    Marenza Leo
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 97:E44-8. 2012
    ....
  32. ncbi request reprint Familial hypocalciuric hypercalcemia in a woman with metastatic breast cancer: a case report of mistaken identity
    Claudio Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Universita degli Studi di Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:5132-6. 2003
    ..In conclusion, we describe a case of familial hypocalciuric hypercalcemia due to a novel CaR mutation, in a woman with breast cancer in whom hypercalcemia was initially attributed to hypercalcemia of malignancy...
  33. ncbi request reprint Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipocytic differentiation
    Patrizia Agretti
    Dipartimento di Endocrinologia e Metabolismo, Centro Eccellenza AmbiSEN Università di Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 152:777-84. 2005
    ..Thyroid-associated ophthalmopathy (TAO) is a chronic autoimmune disorder characterized by an increased volume of adipose/connective tissue in the human orbit...
  34. ncbi request reprint Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy: results of a prospective, single-blind, randomized study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:3562-7. 2001
    ....
  35. ncbi request reprint Microvessel density in human normal and neoplastic parathyroids
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Endocr Pathol 17:175-81. 2006
    ..Therefore, angiogenesis in parathyroid adenomas and carcinomas appears to be an early event, which does not follow a parallel increase in size...
  36. ncbi request reprint Genetic analysis of the MEN1 gene and HPRT2 locus in two Italian kindreds with familial isolated hyperparathyroidism
    Filomena Cetani
    Dipartimenti di Endocrinologia e Metabolismo, Ortopedia e Traumatologia e Medicina del Lavoro, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Clin Endocrinol (Oxf) 56:457-64. 2002
    ....
  37. ncbi request reprint Impaired GH secretion to provocative stimuli in two families with hypocalciuric hypercalcaemia
    Elisabetta Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 59:604-6. 2003
    ..To determine whether hypercalcemia per se might be responsible for an impairment in GH secretion...
  38. ncbi request reprint Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutation
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 58:199-206. 2003
    ..Description of two unrelated Italian kindreds with familial hypocalciuric hypercalcaemia (FHH), an autosomal dominant disease mostly caused by heterozygous inactivating mutations of the Ca2+ sensing receptor (CaR)...
  39. doi request reprint Cinacalcet in the management of primary hyperparathyroidism: post marketing experience of an Italian multicentre group
    Federica Saponaro
    Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 79:20-6. 2013
    ..To report the Italian experience on cinacalcet use following its approval by the European Medical Agency (EMA) to control hypercalcaemia in patients with primary hyperparathyroidism (PHPT)...
  40. doi request reprint Treatment options for Graves' orbitopathy
    Claudio Marcocci
    University of Pisa, Department of Endocrinology and Metabolism, 56127 Pisa, Italy
    Expert Opin Pharmacother 13:795-806. 2012
    ..Treatment of Graves' orbitopathy (GO) is a difficult challenge and should be performed through a multidisciplinary approach...
  41. doi request reprint Fatal and non-fatal adverse events of glucocorticoid therapy for Graves' orbitopathy: a questionnaire survey among members of the European Thyroid Association
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 166:247-53. 2012
    ..The objective of this study was to investigate the side effects of glucocorticoid (GC) therapy observed by European thyroidologists during the treatment of Graves' orbitopathy (GO)...
  42. doi request reprint Selenium and the course of mild Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    N Engl J Med 364:1920-31. 2011
    ..Oxygen free radicals and cytokines play a pathogenic role in Graves' orbitopathy...
  43. doi request reprint Treatment of mild, moderate-to-severe and very severe Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, 56127 Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 26:325-37. 2012
    ..Rehabilitative surgery should be deferred until GO becomes inactive...
  44. doi request reprint The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:920-7. 2010
    ..A compensatory CYP 2C9-derived EDHF pathway is activated to sustain endothelium-dependent vasodilation. This PHPT-related endothelial dysfunction is reversed after PTx...
  45. ncbi request reprint Real-time PCR provides evidence for thyrotropin receptor mRNA expression in orbital as well as in extraorbital tissues
    Patrizia Agretti
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Via Paradisa 2, 56124 Cisanello, Pisa, Italy
    Eur J Endocrinol 147:733-9. 2002
    ..Whether this receptor is expressed in extrathyroidal tissues, and whether it participates directly in the pathogenesis of thyroid-associated ophthalmopathy (TAO) is unclear...
  46. doi request reprint A proteomic approach to study parathyroid glands
    Laura Giusti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via, Bonanno 6, 56126 Pisa, Italy
    Mol Biosyst 7:687-99. 2011
    ..The functional role of these proteins in the network of intracellular pathways is discussed...
  47. ncbi request reprint Spontaneous short-term remission of primary hyperparathyroidism from infarction of a parathyroid adenoma
    F Cetani
    J Endocrinol Invest 27:687-90. 2004
    ..0 x 1.2 cm parathyroid adenoma with areas of necrosis with hemosiderinladen macrophages. In conclusion, we describe a case of spontaneous short-term remission of PHPT due to infarction of parathyroid adenoma...
  48. ncbi request reprint Multidetector CT in diagnostic work-up of patients with primary hyperparathyroidism
    S Mazzeo
    Divisione di Radiologia Diagnostica e Interventistica, Dipartimento di Oncologia, Trapianti e Nuove Tecnologie in Medicina, Pisa, Italy
    Radiol Med 112:763-75. 2007
    ..This study was performed to evaluate the accuracy of multidetector computed tomography (MDCT) in detecting parathyroid lesions in patients with primary hyperparathyroidism...
  49. ncbi request reprint Role of thyroglobulin in the pathogenesis of Graves' ophthalmopathy: the hypothesis of Kriss revisited
    M Marino
    Department of Endocrinology, University of Pisa, Italy
    J Endocrinol Invest 27:230-6. 2004
    ..Our current view is that, provided that Tg plays a role, it is unlikely the only factor involved and Tg in orbital tissues may rather reinforce or worsen a damage initiated by other mechanisms...
  50. ncbi request reprint Cigarette smoking and treatment outcomes in Graves ophthalmopathy
    L Bartalena
    University of Pisa, Italy
    Ann Intern Med 129:632-5. 1998
    ..It is unclear whether smoking affects the course of Graves ophthalmopathy and therapeutic outcomes...
  51. ncbi request reprint Soluble interleukin-1 receptor antagonist concentration in patients with Graves' ophthalmopathy is neither related to cigarette smoking nor predictive of subsequent response to glucocorticoids
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 52:647-51. 2000
    ..The aim of the present study was to evaluate serum soluble interleukin-1 receptor antagonist (sIL-1RA) concentration and its relationship with the degree of cigarette smoking in patients with Graves' ophthalmopathy (GO)...
  52. ncbi request reprint Management of Graves' ophthalmopathy: reality and perspectives
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Italy
    Endocr Rev 21:168-99. 2000
    ..In addition, thyroid ablation may prove beneficial for the ophthalmopathy in view of the pathogenetic model relating eye disease to autoimmune reactions directed against antigens shared by the thyroid and the orbit...
  53. ncbi request reprint Effects of hormonal replacement treatment on bone mineral density and metabolism in hypogonadal patients
    D Canale
    Dipartimento di Endocrinologia, Universita di Pisa, Ospedale di Cisanello, Via Paradisa, 2, 56124, Pisa, Italy
    Mol Cell Endocrinol 161:47-51. 2000
    ..71, P<0.005 for the vertebrae, and r=0.60, P<0.01 for the femur. A weak correlation was also present between onset of HRT and BMD: r=0.6, P<0.01 at the lumbar level, and r=0.47, P<0.05 at the femoral neck...
  54. ncbi request reprint Minimally invasive surgery for thyroid small nodules: preliminary report
    P Miccoli
    Surgery Department, University of Pisa, Italy
    J Endocrinol Invest 22:849-51. 1999
    ..No complications were registered. Cosmetical result was excellent in all patients. MIVA hemythyroidectomy is safe and effective; indications and limits of this new procedure require further studies...
  55. doi request reprint Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 17:1-6. 2010
    ..Our results suggest that the Wnt/beta-catenin signaling pathway is not involved in the development of parathyroid carcinomas and adenomas...
  56. ncbi request reprint Different somatic alterations of the HRPT2 gene in a patient with recurrent sporadic primary hyperparathyroidism carrying an HRPT2 germline mutation
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 14:493-9. 2007
    ....
  57. ncbi request reprint Biochemical and ultrasound tests for early diagnosis of active neuro-osteoarthropathy (NOA) of the diabetic foot
    A Piaggesi
    Department of Endocrinology and Metabolism, Division of Diabetes, University of Pisa, Via Paradisa 2, 56100, Pisa, Italy
    Diabetes Res Clin Pract 58:1-9. 2002
    ....
  58. ncbi request reprint Autoimmune hepatitis during intravenous glucocorticoid pulse therapy for Graves' ophthalmopathy treated successfully with glucocorticoids themselves
    M Marino
    Department of Endocrinology, University Hospital of Pisa, Pisa, Italy
    J Endocrinol Invest 28:280-4. 2005
    ..Complete normalization was achieved two months later, while the patient was still receiving a low maintenance dose of oral prednisone...
  59. ncbi request reprint MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, Orthopedics and Traumatology, and Occupational Medicine, University of Pisa, Italy
    J Endocrinol Invest 25:508-12. 2002
    ..In conclusion, MEN1 gene alterations are rather common in sporadic PHPT and their presence does not correlate with the clinical manifestations of the disease...
  60. doi request reprint Lateral wall orbital decompression in Graves' orbitopathy
    S Sellari-Franceschini
    Unit of Otorhinolaryngology, Department of Neuroscience, University of Pisa, Pisa, Italy
    Int J Oral Maxillofac Surg 39:16-20. 2010
    ..In the authors' opinion, when a single-wall approach is feasible, lateral wall decompression should be the first choice because of its effectiveness in terms of proptosis reduction and safeness in terms of postoperative diplopia...
  61. ncbi request reprint Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment
    F Cetani
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 31:900-4. 2008
    ..A lung 1.5-cm nodule detected by computed tomography was excised. Histology showed a metastasis of parathyroid carcinoma. HRPT2 gene studies improved the diagnostic accuracy in 2 parathyroid tumors that are of uncertain type...
  62. ncbi request reprint Increased prevalence of primary hyperparathyroidism in treated breast cancer
    P Fierabracci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 24:315-20. 2001
    ..We suggest that serum PTH should be determined in all BC patients with increased serum calcium concentration, especially in those with no evidence of metastatic disease...
  63. ncbi request reprint The impact of thyroidectomy on parathyroid glands: a biochemical and clinical profile
    P Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    J Endocrinol Invest 30:666-71. 2007
    ..This study aims to monitor the parathyroid function during total thyroidectomy through intra-operative serial samples for calcium and PTH...
  64. ncbi request reprint A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer
    Filomena Cetani
    Dipartimenti di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 60:99-106. 2004
    ..Some histological features may suggest the malignant nature of a parathyroid tumour. However, the diagnosis of parathyroid cancer can only be definitively established in the presence of local invasion or metastases...
  65. pmc Bone disease in primary hyperparathyrodism
    Claudio Marcocci
    Section of Endocrinology and Bone Metabolism, Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Ther Adv Musculoskelet Dis 4:357-68. 2012
    ..Cinacalcet stably decreased serum calcium levels across a broad range of PHPT severity, but no change in BMD occurred in patients treated for up to 5.5 years...
  66. ncbi request reprint Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 25:614-9. 2002
    ..The A986S polymorphism does not correlate with serum calcium levels in normal Italian subjects...
  67. ncbi request reprint Orbital radiotherapy for Graves' ophthalmopathy: useful or useless? Safe or dangerous?
    L Bartalena
    Department of Endocrinology, University of Insubria, Varese, Italy
    J Endocrinol Invest 26:5-16. 2003
    ..It is recommended that a large, multi-center, prospective, randomized and controlled study with well defined inclusion criteria be carried out to draw sound conclusions on the role of OR in the management of Graves' ophthalmopathy...
  68. ncbi request reprint Poorly specific binding of thyroglobulin to orbital fibroblasts from patients with Graves' ophthalmopathy
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 28:420-4. 2005
    ..Because no appreciable inhibition of binding of biotin-labeled Tg was produced by unlabeled Tg, we concluded that binding was poorly specific and it is unlikely to be involved in the pathogenesis of GO...
  69. doi request reprint Recent advances in the assessment of the ratios of cortisol to cortisone and of some of their metabolites in urine by LC-MS-MS
    Alessandro Saba
    Dipartimento di Chimica e Chimica Industriale, Universita di Pisa, Via Risorgimento 35, 56126 Pisa, Italy
    J Mass Spectrom 44:541-8. 2009
    ..Finally, the improved method has been used to run real samples from healthy volunteers, with satisfactory results...
  70. doi request reprint Subclinical vitamin D deficiency
    Luisella Cianferotti
    Department of Endocrinology and Metabolism, Unit of Endocrinology and Bone Metabolism, University of Pisa, University Hospital of Pisa, Via Paradisa, 2 56124 Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 26:523-37. 2012
    ....
  71. pmc Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glands
    Elena Donadio
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonnanno 6, Pisa, 56126, Italy
    Proteome Sci 9:29. 2011
    ..abstract:..
  72. ncbi request reprint Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women
    F Cetani
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
    Eur J Endocrinol 148:603-7. 2003
    ..We investigated whether the presence of 986S allele was associated with bone mineral density (BMD) and osteoporotic fractures...
  73. ncbi request reprint Growth hormone secretion in primary and secondary hyperparathyroidism
    E Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 28:113-6. 2005
    ..Thus, hypercalcemia rather than increased serum PTH is responsible for the abnormality of GH secretion...
  74. ncbi request reprint Primary hyperparathyroidism is associated with an impaired secretion of growth hormone but not of the other anterior pituitary hormones
    E Cecconi
    Department of Endocrinology, University of Pisa, Italy
    J Endocrinol Invest 25:RC7-9. 2002
    ..Thus, PHP is associated with an impaired secretion of GH, but not of the other anterior pituitary hormones. The reason why only GH secretion is affected in PHP is unknown...
  75. ncbi request reprint GH secretion is impaired in patients with primary hyperparathyroidism
    M Gasperi
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:1961-4. 2002
    ..Accordingly, PHP should be mentioned as a further example of a metabolic condition in which GH secretion in adults is reduced...
  76. ncbi request reprint A quick intraoperative parathyroid hormone assay in the surgical management of patients with primary hyperparathyroidism: a study of 206 consecutive cases
    E Vignali
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 146:783-8. 2002
    ..The traditional surgical approach for patients with primary hyperparathyroidism (PHPT) consists of the identification of at least four glands and in the removal of all hyperfunctioning parathyroid tissue...
  77. ncbi request reprint Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:1105-10. 2003
    ..Therefore, we concluded that RAP is involved in Tg secretion by FRTL-5 cells suggesting that RAP may function as a Tg molecular chaperone...
  78. ncbi request reprint Post-menopausal osteoporosis: is it an autoimmune disease?
    E Ambrogini
    Department of Endocrinology and Metabolism, University of Pisa, Pisa Italy
    J Endocrinol Invest 28:43-7. 2005
    ..The protective role of estrogen on bone loss is mediated by type beta transforming growth factor (TGF-beta), which blocks T-cell activation and T-cell TNF-alpha production by repressing antigen presentation...
  79. ncbi request reprint Epidemiology of primary hyperparathyroidism in Europe
    Silvano Adami
    Rheumatologic Unit, University of Verona, Italy
    J Bone Miner Res 17:N18-23. 2002
    ..quot; Other environmental, nutritional, or iatrogenic factors might influence the incidence of the disease, but the overall effect is unlikely to be relevant...
  80. ncbi request reprint Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience
    Mark F Prummel
    Department of Endocrinology and Metabolism, F5 171 Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 148:491-5. 2003
    ..The European Group on Graves' Orbitopathy aims to overcome this and has designed a preliminary case record form (CRF) to assess Graves' orbitopathy patients. This form was used in this first multi-center study...
  81. doi request reprint Parafibromin as a tool for the diagnosis of parathyroid tumors
    Claudio Marcocci
    Adv Anat Pathol 15:179; author reply 179-80. 2008
  82. ncbi request reprint Somatostatin analogs for Graves' ophthalmopathy: do they bounce off like a rubber bullet?
    Luigi Bartalena
    J Clin Endocrinol Metab 89:5908-9. 2004
  83. ncbi request reprint Graves' ophthalmopathy: a preventable disease?
    Luigi Bartalena
    Cattedra di Endocrinologia, University of Insubria, Varese, Italy
    Eur J Endocrinol 146:457-61. 2002
    ....
  84. ncbi request reprint Orbital radiotherapy for Graves' ophthalmopathy
    Luigi Bartalena
    J Clin Endocrinol Metab 89:13-4. 2004
  85. ncbi request reprint Orbital radiotherapy for Graves' ophthalmopathy
    Luigi Bartalena
    Cattedra di Endocrinologia, University of Insubria, Varese, Italy
    Thyroid 12:245-50. 2002
    ..g., in patients with diabetes) is a contraindication to this treatment for the risk of further retinal damage. No case of radiation-induced tumors has so far been described after orbital radiotherapy for Graves' ophthalmopathy...
  86. doi request reprint Novel immunomodulating agents for Graves orbitopathy
    Luigi Bartalena
    Department of Clinical Medicine, University of Insubria, Division of Endocrinology, Ospedale di Circolo, Varese, Italy
    Ophthal Plast Reconstr Surg 24:251-6. 2008