Claudio Marcocci

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi Fluoride and anabolic steroids in the treatment of glucocorticoid-induced osteoporosis
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia e Medicina del Lavoro, , Pisa, Italia
    Front Horm Res 30:165-73. 2002
  2. ncbi Long-term safety of orbital radiotherapy for Graves' ophthalmopathy
    Claudio Marcocci
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:3561-6. 2003
  3. ncbi Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 94:2766-72. 2009
  4. ncbi Current medical management of Graves ophthalmopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Ophthal Plast Reconstr Surg 18:402-8. 2002
  5. ncbi A treatment strategy for Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Nat Clin Pract Endocrinol Metab 3:430-6. 2007
  6. ncbi Novel aspects of immunosuppressive and radiotherapy management of Graves' ophthalmopathy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:272-80. 2004
  7. ncbi Graves' ophthalmopathy and 131I therapy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Q J Nucl Med 43:307-12. 1999
  8. ncbi The course of Graves' ophthalmopathy is not influenced by near total thyroidectomy: a case-control study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Pisa, Italy
    Clin Endocrinol (Oxf) 51:503-8. 1999
  9. ncbi TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells
    Roberta Botta
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy
    Thyroid 16:1097-104. 2006
  10. ncbi Identification and functional characterization of loss-of-function mutations of the calcium-sensing receptor in four Italian kindreds with familial hypocalciuric hypercalcemia
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 160:481-9. 2009

Detail Information

Publications82

  1. ncbi Fluoride and anabolic steroids in the treatment of glucocorticoid-induced osteoporosis
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia e Medicina del Lavoro, , Pisa, Italia
    Front Horm Res 30:165-73. 2002
  2. ncbi Long-term safety of orbital radiotherapy for Graves' ophthalmopathy
    Claudio Marcocci
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:3561-6. 2003
    ..Although no secondary tumors were detected, due to the long latency of radiation-induced tumors, OR should be restricted to patients older than 35 yr...
  3. ncbi Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 94:2766-72. 2009
    ..Patients with persistent primary hyperparathyroidism (PHPT) after parathyroidectomy or with contraindications to parathyroidectomy often require chronic treatment for hypercalcemia...
  4. ncbi Current medical management of Graves ophthalmopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Ophthal Plast Reconstr Surg 18:402-8. 2002
  5. ncbi A treatment strategy for Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Nat Clin Pract Endocrinol Metab 3:430-6. 2007
    ..After glucocorticoid withdrawal, however, the patient's eye motility worsened and there was a reduction of visual acuity in the left eye. She was then referred to our hospital for further advice and treatment...
  6. ncbi Novel aspects of immunosuppressive and radiotherapy management of Graves' ophthalmopathy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:272-80. 2004
    ..New data on recently performed placebo-controlled studies on orbital radiotherapy are discussed, together with studies on long-term safety of orbital radiotherapy...
  7. ncbi Graves' ophthalmopathy and 131I therapy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Q J Nucl Med 43:307-12. 1999
    ..Glucocorticoid treatment should be limited, in our opinion, to patients with clinically evident eye disease and to those without ophthalmopathy but with other known risk factors, such as smoking...
  8. ncbi The course of Graves' ophthalmopathy is not influenced by near total thyroidectomy: a case-control study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Pisa, Italy
    Clin Endocrinol (Oxf) 51:503-8. 1999
    ..Although controversial, radioiodine may be followed by progression of eye disease, preventable by glucocorticoid administration. Whether thyroidectomy affects the course of ophthalmopathy is uncertain...
  9. ncbi TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells
    Roberta Botta
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy
    Thyroid 16:1097-104. 2006
    ..Based on these findings, we concluded that RAP is expressed by thyrocytes in a TSH-dependent manner, both in cultured thyroid cells and in vivo...
  10. ncbi Identification and functional characterization of loss-of-function mutations of the calcium-sensing receptor in four Italian kindreds with familial hypocalciuric hypercalcemia
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 160:481-9. 2009
    ..Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia...
  11. ncbi Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 156:547-54. 2007
    ..The aim of our study was to extend parafibromin studies in a series of benign and malignant parathyroid tumors and cross-validate the results of immunohistochemistry with those of HRPT2 analysis...
  12. ncbi Thyroid dysfunction in megalin deficient mice
    Simonetta Lisi
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Mol Cell Endocrinol 236:43-7. 2005
    ..Although the serological phenotype in megalin-/- mice was not associated with histological alterations or goiter, our results support a major role of megalin in thyroid hormone secretion...
  13. ncbi Improvement of growth hormone deficiency in patients with primary hyperparathyroidism after parathyroidectomy: results of a prospective study
    Elisabetta Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:1213-6. 2004
    ..Accordingly, GH deficiency in PHP patients must be considered a functional phenomenon for which GH therapy is not recommended...
  14. ncbi Genetic analyses in familial isolated hyperparathyroidism: implication for clinical assessment and surgical management
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 64:146-52. 2006
    ..Design Genetic analyses of MEN1, HRPT2 and CASR genes in FIHP...
  15. ncbi Sortilin is a putative postendocytic receptor of thyroglobulin
    Roberta Botta
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy
    Endocrinology 150:509-18. 2009
    ..Our findings provide a novel pathway of Tg trafficking and a novel function of sortilin in the thyroid gland, the functional impact of which remains to be established...
  16. ncbi Effects of total thyroid ablation versus near-total thyroidectomy alone on mild to moderate Graves' orbitopathy treated with intravenous glucocorticoids
    Francesca Menconi
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1653-8. 2007
    ..Total thyroid ablation (TTA) may be beneficial for GO through removal of shared antigen(s) and autoreactive T-lymphocytes, but randomized studies are lacking...
  17. ncbi Surgery or surveillance for mild asymptomatic primary hyperparathyroidism: a prospective, randomized clinical trial
    Elena Ambrogini
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 92:3114-21. 2007
    ..It is unclear whether patients with asymptomatic primary hyperparathyroidism (PHPT) do better with parathyroidectomy (PTx) as compared with conservative medical management...
  18. ncbi The reduction of bone mineral density in postmenopausal women with primary hyperparathyroidism is higher in the presence of concomitant GH secretion impairment
    Elisabetta Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Ospedale, Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 155:41-5. 2006
    ..CONCLUSIONS: Concomitant impairment of GH secretion may play a pathogenetic role in the occurrence of changes in bone mass observed in PHP and contribute to make them more severe...
  19. ncbi Orbital decompression in graves' ophthalmopathy by medial and lateral wall removal
    Stefano Sellari-Franceschini
    Department of Neuroscience, Ia ENT division, Pisa, Italy
    Otolaryngol Head Neck Surg 133:185-9. 2005
    ..The objective of this study is to describe a technique for balanced orbital decompression and to analyze the results...
  20. ncbi Morphometric vertebral fractures in postmenopausal women with primary hyperparathyroidism
    Edda Vignali
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 94:2306-12. 2009
    ..An increased risk of fracture in patients with primary hyperparathyroidism (PHPT) compared to the general population has been reported, but available data are controversial...
  21. ncbi Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5583-91. 2004
    ..The finding that two of the seven patients with sporadic parathyroid cancer carried an HRPT2 germline mutation suggests that they might have occult HPT-JT. Our results also confirm the need for testing HRPT2 gene in FIHP families...
  22. ncbi Enalapril reduces proliferation and hyaluronic acid release in orbital fibroblasts
    Roberta Botta
    Endocrinology, University of Pisa, Pisa, Italy
    Thyroid 23:92-6. 2013
    ....
  23. ncbi Glycosaminoglycans provide a binding site for thyroglobulin in orbital tissues of patients with thyroid-associated ophthalmopathy
    Michele Marino
    Department of Endocrinology, University of Pisa, Pisa, Italy
    Thyroid 13:851-9. 2003
    ..Therefore, we conclude that GAGs provide binding sites for Tg in orbital tissues, which may explain the presence of Tg in orbital tissues of patients with TAO...
  24. ncbi Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice
    Simonetta Lisi
    Department of Endocrinology, University of Pisa, Via Paradisa 2, I 56124 Pisa, Italy
    Am J Physiol Cell Physiol 290:C1160-7. 2006
    ..In conclusion, RAP is required for the establishment of Tg reservoirs, but its absence does not affect hormone secretion...
  25. ncbi Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release
    Simonetta Lisi
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Proc Natl Acad Sci U S A 100:14858-63. 2003
    ..Our study points to a major role of megalin in thyroid homeostasis with possible implications in thyroid diseases...
  26. ncbi Management of thyroid eye disease
    Luigi Bartalena
    Department of Endocrinology, University of Insubria, Ospedale di Circolo, Viale Borri, 57, 21100 Varese, Italy
    Eur J Nucl Med Mol Imaging 29:S458-65. 2002
    ..A coordinated approach to the treatment of hyperthyroidism and TED is also required. Novel promising treatments, to be verified in large series of patients, include somatostatin analogues and cytokine antagonists...
  27. ncbi Thyroid volume and severity of graves' orbitopathy
    Maria Antonietta Profilo
    Endocrinology Unit, University Hospital of Pisa, Pisa, Italy
    Thyroid 23:97-102. 2013
    ..Thus, we evaluated retrospectively whether there is a correlation between the degree of GO at its first observation and, among other parameters, the thyroid volume...
  28. ncbi Outcome of Graves' orbitopathy after total thyroid ablation and glucocorticoid treatment: follow-up of a randomized clinical trial
    Marenza Leo
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 97:E44-8. 2012
    ....
  29. ncbi Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipocytic differentiation
    Patrizia Agretti
    Dipartimento di Endocrinologia e Metabolismo, Centro Eccellenza AmbiSEN Università di Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 152:777-84. 2005
    ..Thyroid-associated ophthalmopathy (TAO) is a chronic autoimmune disorder characterized by an increased volume of adipose/connective tissue in the human orbit...
  30. ncbi Familial hypocalciuric hypercalcemia in a woman with metastatic breast cancer: a case report of mistaken identity
    Claudio Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Universita degli Studi di Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:5132-6. 2003
    ..In conclusion, we describe a case of familial hypocalciuric hypercalcemia due to a novel CaR mutation, in a woman with breast cancer in whom hypercalcemia was initially attributed to hypercalcemia of malignancy...
  31. ncbi Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy: results of a prospective, single-blind, randomized study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:3562-7. 2001
    ....
  32. ncbi Rehabilitative orbital decompression for Graves' orbitopathy: risk factors influencing the new onset of diplopia in primary gaze, outcome, and patients' satisfaction
    Roberto Rocchi
    Unit of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Thyroid 22:1170-5. 2012
    ..Moreover, we investigated the results in terms of proptosis reduction, and the long-term subjective satisfaction of patients treated with OD with regard to their appearance and ocular function...
  33. ncbi Microvessel density in human normal and neoplastic parathyroids
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Endocr Pathol 17:175-81. 2006
    ..Therefore, angiogenesis in parathyroid adenomas and carcinomas appears to be an early event, which does not follow a parallel increase in size...
  34. ncbi Genetic analysis of the MEN1 gene and HPRT2 locus in two Italian kindreds with familial isolated hyperparathyroidism
    Filomena Cetani
    Dipartimenti di Endocrinologia e Metabolismo, Ortopedia e Traumatologia e Medicina del Lavoro, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Clin Endocrinol (Oxf) 56:457-64. 2002
    ..Therefore, an extensive analysis of the genes involved in these diseases should be performed in families with familial isolated hyperparathyroidism to identify the subset linked to the MEN1 gene or to the HPRT2 locus...
  35. ncbi Impaired GH secretion to provocative stimuli in two families with hypocalciuric hypercalcaemia
    Elisabetta Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 59:604-6. 2003
    ..CONCLUSIONS: The results of the present study support the concept that elevated serum calcium levels impair GH secretion. However, the clinical relevance of GH deficiency in FHH remains to be elucidated...
  36. ncbi Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutation
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, , Pisa, Italy
    Clin Endocrinol (Oxf) 58:199-206. 2003
    ....
  37. ncbi Treatment options for Graves' orbitopathy
    Claudio Marcocci
    University of Pisa, Department of Endocrinology and Metabolism, 56127 Pisa, Italy
    Expert Opin Pharmacother 13:795-806. 2012
    ..Oral GC should be given to patients with risk factors or active GO, if radioiodine is used...
  38. ncbi Fatal and non-fatal adverse events of glucocorticoid therapy for Graves' orbitopathy: a questionnaire survey among members of the European Thyroid Association
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 166:247-53. 2012
    ..The objective of this study was to investigate the side effects of glucocorticoid (GC) therapy observed by European thyroidologists during the treatment of Graves' orbitopathy (GO)...
  39. ncbi Selenium and the course of mild Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    N Engl J Med 364:1920-31. 2011
    ..Oxygen free radicals and cytokines play a pathogenic role in Graves' orbitopathy...
  40. ncbi Treatment of mild, moderate-to-severe and very severe Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, 56127 Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 26:325-37. 2012
    ..Rehabilitative surgery should be deferred until GO becomes inactive...
  41. ncbi Real-time PCR provides evidence for thyrotropin receptor mRNA expression in orbital as well as in extraorbital tissues
    Patrizia Agretti
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Via Paradisa 2, 56124 Cisanello, Pisa, Italy
    Eur J Endocrinol 147:733-9. 2002
    ..These data suggest an illegitimate TSHr mRNA transcription in all the tissues examined apart from thyroid...
  42. ncbi The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:920-7. 2010
    ..A compensatory CYP 2C9-derived EDHF pathway is activated to sustain endothelium-dependent vasodilation. This PHPT-related endothelial dysfunction is reversed after PTx...
  43. ncbi A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer
    Filomena Cetani
    Dipartimenti di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, , Pisa, Italy
    Clin Endocrinol (Oxf) 60:99-106. 2004
    ..Retention of heterozygosity seems to exclude parathyroid malignancy, which is suggested by the combined finding of LOH and lack of protein expression...
  44. ncbi A proteomic approach to study parathyroid glands
    Laura Giusti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via, Bonanno 6, 56126 Pisa, Italy
    Mol Biosyst 7:687-99. 2011
    ..The functional role of these proteins in the network of intracellular pathways is discussed...
  45. ncbi Management of Graves' ophthalmopathy: reality and perspectives
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Italy
    Endocr Rev 21:168-99. 2000
    ..In addition, thyroid ablation may prove beneficial for the ophthalmopathy in view of the pathogenetic model relating eye disease to autoimmune reactions directed against antigens shared by the thyroid and the orbit...
  46. ncbi Biochemical and ultrasound tests for early diagnosis of active neuro-osteoarthropathy (NOA) of the diabetic foot
    A Piaggesi
    Department of Endocrinology and Metabolism, Division of Diabetes, University of Pisa, Via Paradisa 2, 56100, Pisa, Italy
    Diabetes Res Clin Pract 58:1-9. 2002
    ....
  47. ncbi MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, Orthopedics and Traumatology, and Occupational Medicine, University of Pisa, Italy
    J Endocrinol Invest 25:508-12. 2002
    ..In conclusion, MEN1 gene alterations are rather common in sporadic PHPT and their presence does not correlate with the clinical manifestations of the disease...
  48. ncbi Different somatic alterations of the HRPT2 gene in a patient with recurrent sporadic primary hyperparathyroidism carrying an HRPT2 germline mutation
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 14:493-9. 2007
    ....
  49. ncbi Multidetector CT in diagnostic work-up of patients with primary hyperparathyroidism
    S Mazzeo
    Divisione di Radiologia Diagnostica e Interventistica, Dipartimento di Oncologia, Trapianti e Nuove Tecnologie in Medicina, Pisa, Italy
    Radiol Med 112:763-75. 2007
    ..This study was performed to evaluate the accuracy of multidetector computed tomography (MDCT) in detecting parathyroid lesions in patients with primary hyperparathyroidism...
  50. ncbi Soluble interleukin-1 receptor antagonist concentration in patients with Graves' ophthalmopathy is neither related to cigarette smoking nor predictive of subsequent response to glucocorticoids
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 52:647-51. 2000
    ..The aim of the present study was to evaluate serum soluble interleukin-1 receptor antagonist (sIL-1RA) concentration and its relationship with the degree of cigarette smoking in patients with Graves' ophthalmopathy (GO)...
  51. ncbi Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 17:1-6. 2010
    ..Our results suggest that the Wnt/beta-catenin signaling pathway is not involved in the development of parathyroid carcinomas and adenomas...
  52. ncbi Spontaneous short-term remission of primary hyperparathyroidism from infarction of a parathyroid adenoma
    F Cetani
    J Endocrinol Invest 27:687-90. 2004
    ..0 x 1.2 cm parathyroid adenoma with areas of necrosis with hemosiderinladen macrophages. In conclusion, we describe a case of spontaneous short-term remission of PHPT due to infarction of parathyroid adenoma...
  53. ncbi Autoimmune hepatitis during intravenous glucocorticoid pulse therapy for Graves' ophthalmopathy treated successfully with glucocorticoids themselves
    M Marino
    Department of Endocrinology, University Hospital of Pisa, Pisa, Italy
    J Endocrinol Invest 28:280-4. 2005
    ..Complete normalization was achieved two months later, while the patient was still receiving a low maintenance dose of oral prednisone...
  54. ncbi Effects of hormonal replacement treatment on bone mineral density and metabolism in hypogonadal patients
    D Canale
    Dipartimento di Endocrinologia, Universita di Pisa, Ospedale di Cisanello, Via Paradisa, 2, 56124, Pisa, Italy
    Mol Cell Endocrinol 161:47-51. 2000
    ..71, P<0.005 for the vertebrae, and r=0.60, P<0.01 for the femur. A weak correlation was also present between onset of HRT and BMD: r=0.6, P<0.01 at the lumbar level, and r=0.47, P<0.05 at the femoral neck...
  55. ncbi Cigarette smoking and treatment outcomes in Graves ophthalmopathy
    L Bartalena
    University of Pisa, Italy
    Ann Intern Med 129:632-5. 1998
    ..It is unclear whether smoking affects the course of Graves ophthalmopathy and therapeutic outcomes...
  56. ncbi Role of thyroglobulin in the pathogenesis of Graves' ophthalmopathy: the hypothesis of Kriss revisited
    M Marino
    Department of Endocrinology, University of Pisa, Italy
    J Endocrinol Invest 27:230-6. 2004
    ..Our current view is that, provided that Tg plays a role, it is unlikely the only factor involved and Tg in orbital tissues may rather reinforce or worsen a damage initiated by other mechanisms...
  57. ncbi Minimally invasive surgery for thyroid small nodules: preliminary report
    P Miccoli
    Surgery Department, University of Pisa, Italy
    J Endocrinol Invest 22:849-51. 1999
    ..No complications were registered. Cosmetical result was excellent in all patients. MIVA hemythyroidectomy is safe and effective; indications and limits of this new procedure require further studies...
  58. ncbi Increased prevalence of primary hyperparathyroidism in treated breast cancer
    P Fierabracci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 24:315-20. 2001
    ..We suggest that serum PTH should be determined in all BC patients with increased serum calcium concentration, especially in those with no evidence of metastatic disease...
  59. ncbi Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment
    F Cetani
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 31:900-4. 2008
    ..A lung 1.5-cm nodule detected by computed tomography was excised. Histology showed a metastasis of parathyroid carcinoma. HRPT2 gene studies improved the diagnostic accuracy in 2 parathyroid tumors that are of uncertain type...
  60. ncbi Lateral wall orbital decompression in Graves' orbitopathy
    S Sellari-Franceschini
    Unit of Otorhinolaryngology, Department of Neuroscience, University of Pisa, Pisa, Italy
    Int J Oral Maxillofac Surg 39:16-20. 2010
    ..In the authors' opinion, when a single-wall approach is feasible, lateral wall decompression should be the first choice because of its effectiveness in terms of proptosis reduction and safeness in terms of postoperative diplopia...
  61. ncbi The impact of thyroidectomy on parathyroid glands: a biochemical and clinical profile
    P Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    J Endocrinol Invest 30:666-71. 2007
    ..This study aims to monitor the parathyroid function during total thyroidectomy through intra-operative serial samples for calcium and PTH...
  62. ncbi Bone disease in primary hyperparathyrodism
    Claudio Marcocci
    Section of Endocrinology and Bone Metabolism, Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Ther Adv Musculoskelet Dis 4:357-68. 2012
    ..Cinacalcet stably decreased serum calcium levels across a broad range of PHPT severity, but no change in BMD occurred in patients treated for up to 5.5 years...
  63. ncbi Poorly specific binding of thyroglobulin to orbital fibroblasts from patients with Graves' ophthalmopathy
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 28:420-4. 2005
    ..Because no appreciable inhibition of binding of biotin-labeled Tg was produced by unlabeled Tg, we concluded that binding was poorly specific and it is unlikely to be involved in the pathogenesis of GO...
  64. ncbi Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 25:614-9. 2002
    ..The A986S polymorphism does not correlate with serum calcium levels in normal Italian subjects...
  65. ncbi Orbital radiotherapy for Graves' ophthalmopathy: useful or useless? Safe or dangerous?
    L Bartalena
    Department of Endocrinology, University of Insubria, Varese, Italy
    J Endocrinol Invest 26:5-16. 2003
    ..It is recommended that a large, multi-center, prospective, randomized and controlled study with well defined inclusion criteria be carried out to draw sound conclusions on the role of OR in the management of Graves' ophthalmopathy...
  66. ncbi Subclinical vitamin D deficiency
    Luisella Cianferotti
    Department of Endocrinology and Metabolism, Unit of Endocrinology and Bone Metabolism, University of Pisa, University Hospital of Pisa, Via Paradisa, 2 56124 Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 26:523-37. 2012
    ....
  67. ncbi Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glands
    Elena Donadio
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonnanno 6, Pisa, 56126, Italy
    Proteome Sci 9:29. 2011
    ..abstract:..
  68. ncbi Growth hormone secretion in primary and secondary hyperparathyroidism
    E Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 28:113-6. 2005
    ..Thus, hypercalcemia rather than increased serum PTH is responsible for the abnormality of GH secretion...
  69. ncbi Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women
    F Cetani
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
    Eur J Endocrinol 148:603-7. 2003
    ..We investigated whether the presence of 986S allele was associated with bone mineral density (BMD) and osteoporotic fractures...
  70. ncbi Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:1105-10. 2003
    ..Therefore, we concluded that RAP is involved in Tg secretion by FRTL-5 cells suggesting that RAP may function as a Tg molecular chaperone...
  71. ncbi GH secretion is impaired in patients with primary hyperparathyroidism
    M Gasperi
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:1961-4. 2002
    ..Accordingly, PHP should be mentioned as a further example of a metabolic condition in which GH secretion in adults is reduced...
  72. ncbi A quick intraoperative parathyroid hormone assay in the surgical management of patients with primary hyperparathyroidism: a study of 206 consecutive cases
    E Vignali
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, , Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 146:783-8. 2002
    ..It indicates whether all hyperfunctioning parathyroid tissue has been removed, limiting the procedure to a unilateral neck exploration in most cases...
  73. ncbi Primary hyperparathyroidism is associated with an impaired secretion of growth hormone but not of the other anterior pituitary hormones
    E Cecconi
    Department of Endocrinology, University of Pisa, Italy
    J Endocrinol Invest 25:RC7-9. 2002
    ..Thus, PHP is associated with an impaired secretion of GH, but not of the other anterior pituitary hormones. The reason why only GH secretion is affected in PHP is unknown...
  74. ncbi Post-menopausal osteoporosis: is it an autoimmune disease?
    E Ambrogini
    Department of Endocrinology and Metabolism, University of Pisa, Pisa Italy
    J Endocrinol Invest 28:43-7. 2005
    ..The protective role of estrogen on bone loss is mediated by type beta transforming growth factor (TGF-beta), which blocks T-cell activation and T-cell TNF-alpha production by repressing antigen presentation...
  75. ncbi Parafibromin as a tool for the diagnosis of parathyroid tumors
    Claudio Marcocci
    Adv Anat Pathol 15:179; author reply 179-80. 2008
  76. ncbi Epidemiology of primary hyperparathyroidism in Europe
    Silvano Adami
    Rheumatologic Unit, University of Verona, Italy
    J Bone Miner Res 17:N18-23. 2002
    ..quot; Other environmental, nutritional, or iatrogenic factors might influence the incidence of the disease, but the overall effect is unlikely to be relevant...
  77. ncbi Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience
    Mark F Prummel
    Department of Endocrinology and Metabolism, F5 171 Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 148:491-5. 2003
    ..The European Group on Graves' Orbitopathy aims to overcome this and has designed a preliminary case record form (CRF) to assess Graves' orbitopathy patients. This form was used in this first multi-center study...
  78. ncbi Graves' ophthalmopathy: a preventable disease?
    Luigi Bartalena
    Cattedra di Endocrinologia, University of Insubria, Varese, Italy
    Eur J Endocrinol 146:457-61. 2002
    ....
  79. ncbi Orbital radiotherapy for Graves' ophthalmopathy
    Luigi Bartalena
    J Clin Endocrinol Metab 89:13-4. 2004
  80. ncbi Orbital radiotherapy for Graves' ophthalmopathy
    Luigi Bartalena
    Cattedra di Endocrinologia, University of Insubria, Varese, Italy
    Thyroid 12:245-50. 2002
    ..g., in patients with diabetes) is a contraindication to this treatment for the risk of further retinal damage. No case of radiation-induced tumors has so far been described after orbital radiotherapy for Graves' ophthalmopathy...
  81. ncbi Somatostatin analogs for Graves' ophthalmopathy: do they bounce off like a rubber bullet?
    Luigi Bartalena
    J Clin Endocrinol Metab 89:5908-9. 2004
  82. ncbi Novel immunomodulating agents for Graves orbitopathy
    Luigi Bartalena
    Department of Clinical Medicine, University of Insubria, Division of Endocrinology, Ospedale di Circolo, Varese, Italy
    Ophthal Plast Reconstr Surg 24:251-6. 2008