C Marcocci

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. doi request reprint Update on the use of cinacalcet in the management of primary hyperparathyroidism
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 35:90-5. 2012
  2. doi request reprint Aryl hydrocarbon receptor interacting protein (AIP) mutations occur rarely in sporadic parathyroid adenomas
    Elena Pardi
    Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 98:2800-10. 2013
  3. doi request reprint Treatment of mild, moderate-to-severe and very severe Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, 56127 Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 26:325-37. 2012
  4. doi request reprint Treatment options for Graves' orbitopathy
    Claudio Marcocci
    University of Pisa, Department of Endocrinology and Metabolism, 56127 Pisa, Italy
    Expert Opin Pharmacother 13:795-806. 2012
  5. doi request reprint Selenium and the course of mild Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    N Engl J Med 364:1920-31. 2011
  6. doi request reprint Fatal and non-fatal adverse events of glucocorticoid therapy for Graves' orbitopathy: a questionnaire survey among members of the European Thyroid Association
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 166:247-53. 2012
  7. ncbi request reprint Cigarette smoking and treatment outcomes in Graves ophthalmopathy
    L Bartalena
    University of Pisa, Italy
    Ann Intern Med 129:632-5. 1998
  8. ncbi request reprint Growth hormone secretion in primary and secondary hyperparathyroidism
    E Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 28:113-6. 2005
  9. ncbi request reprint Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy: results of a prospective, single-blind, randomized study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:3562-7. 2001
  10. doi request reprint Cinacalcet efficacy in patients with moderately severe primary hyperparathyroidism according to the European Medicine Agency prescription labeling
    F Cetani
    Department of Endocrinology and Metabolism, Section of Endocrinology and Bone Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Endocrinol Invest 35:655-60. 2012

Collaborators

Detail Information

Publications44

  1. doi request reprint Update on the use of cinacalcet in the management of primary hyperparathyroidism
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 35:90-5. 2012
    ..Moreover, there are no data as to whether long-term treatment with cinacalcet can prevent the complications of PHPT. Finally, more data are needed on the long-term safety of cinacalcet, particularly at the renal level...
  2. doi request reprint Aryl hydrocarbon receptor interacting protein (AIP) mutations occur rarely in sporadic parathyroid adenomas
    Elena Pardi
    Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 98:2800-10. 2013
    ..The molecular pathogenesis of primary hyperparathyroidism is still largely unknown. The aryl hydrocarbon receptor interacting protein (AIP) gene has a major role in the pathogenesis of familial isolated pituitary adenoma...
  3. doi request reprint Treatment of mild, moderate-to-severe and very severe Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, 56127 Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 26:325-37. 2012
    ..Rehabilitative surgery should be deferred until GO becomes inactive...
  4. doi request reprint Treatment options for Graves' orbitopathy
    Claudio Marcocci
    University of Pisa, Department of Endocrinology and Metabolism, 56127 Pisa, Italy
    Expert Opin Pharmacother 13:795-806. 2012
    ..Treatment of Graves' orbitopathy (GO) is a difficult challenge and should be performed through a multidisciplinary approach...
  5. doi request reprint Selenium and the course of mild Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    N Engl J Med 364:1920-31. 2011
    ..Oxygen free radicals and cytokines play a pathogenic role in Graves' orbitopathy...
  6. doi request reprint Fatal and non-fatal adverse events of glucocorticoid therapy for Graves' orbitopathy: a questionnaire survey among members of the European Thyroid Association
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 166:247-53. 2012
    ..The objective of this study was to investigate the side effects of glucocorticoid (GC) therapy observed by European thyroidologists during the treatment of Graves' orbitopathy (GO)...
  7. ncbi request reprint Cigarette smoking and treatment outcomes in Graves ophthalmopathy
    L Bartalena
    University of Pisa, Italy
    Ann Intern Med 129:632-5. 1998
    ..It is unclear whether smoking affects the course of Graves ophthalmopathy and therapeutic outcomes...
  8. ncbi request reprint Growth hormone secretion in primary and secondary hyperparathyroidism
    E Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 28:113-6. 2005
    ..Thus, hypercalcemia rather than increased serum PTH is responsible for the abnormality of GH secretion...
  9. ncbi request reprint Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy: results of a prospective, single-blind, randomized study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:3562-7. 2001
    ....
  10. doi request reprint Cinacalcet efficacy in patients with moderately severe primary hyperparathyroidism according to the European Medicine Agency prescription labeling
    F Cetani
    Department of Endocrinology and Metabolism, Section of Endocrinology and Bone Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Endocrinol Invest 35:655-60. 2012
    ..Patients with primary hyperparathyroidism (PHPT) with contraindications to parathyroidectomy (PTx) or persistent PHPT have few non surgical options...
  11. ncbi request reprint The course of Graves' ophthalmopathy is not influenced by near total thyroidectomy: a case-control study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Pisa, Italy
    Clin Endocrinol (Oxf) 51:503-8. 1999
    ..Although controversial, radioiodine may be followed by progression of eye disease, preventable by glucocorticoid administration. Whether thyroidectomy affects the course of ophthalmopathy is uncertain...
  12. ncbi request reprint Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 25:614-9. 2002
    ..The A986S polymorphism does not correlate with serum calcium levels in normal Italian subjects...
  13. ncbi request reprint Graves' ophthalmopathy and 131I therapy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Q J Nucl Med 43:307-12. 1999
    ..Glucocorticoid treatment should be limited, in our opinion, to patients with clinically evident eye disease and to those without ophthalmopathy but with other known risk factors, such as smoking...
  14. ncbi request reprint Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women
    F Cetani
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
    Eur J Endocrinol 148:603-7. 2003
    ..We investigated whether the presence of 986S allele was associated with bone mineral density (BMD) and osteoporotic fractures...
  15. ncbi request reprint The impact of thyroidectomy on parathyroid glands: a biochemical and clinical profile
    P Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    J Endocrinol Invest 30:666-71. 2007
    ..This study aims to monitor the parathyroid function during total thyroidectomy through intra-operative serial samples for calcium and PTH...
  16. ncbi request reprint MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, Orthopedics and Traumatology, and Occupational Medicine, University of Pisa, Italy
    J Endocrinol Invest 25:508-12. 2002
    ..In conclusion, MEN1 gene alterations are rather common in sporadic PHPT and their presence does not correlate with the clinical manifestations of the disease...
  17. doi request reprint Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 17:1-6. 2010
    ..Our results suggest that the Wnt/beta-catenin signaling pathway is not involved in the development of parathyroid carcinomas and adenomas...
  18. ncbi request reprint Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment
    F Cetani
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 31:900-4. 2008
    ..A lung 1.5-cm nodule detected by computed tomography was excised. Histology showed a metastasis of parathyroid carcinoma. HRPT2 gene studies improved the diagnostic accuracy in 2 parathyroid tumors that are of uncertain type...
  19. ncbi request reprint GH secretion is impaired in patients with primary hyperparathyroidism
    M Gasperi
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:1961-4. 2002
    ..Accordingly, PHP should be mentioned as a further example of a metabolic condition in which GH secretion in adults is reduced...
  20. doi request reprint Quercetin decreases proliferation of orbital fibroblasts and their release of hyaluronic acid
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 34:521-7. 2011
    ..Inhibition of fibroblast (FB) proliferation and hyaluronic acid (HA) production may be a therapeutic approach to Graves' ophthalmopathy (GO). The flavonoid quercetin has a wide range of activities, including reduction of FB growth...
  21. doi request reprint Lateral wall orbital decompression in Graves' orbitopathy
    S Sellari-Franceschini
    Unit of Otorhinolaryngology, Department of Neuroscience, University of Pisa, Pisa, Italy
    Int J Oral Maxillofac Surg 39:16-20. 2010
    ..In the authors' opinion, when a single-wall approach is feasible, lateral wall decompression should be the first choice because of its effectiveness in terms of proptosis reduction and safeness in terms of postoperative diplopia...
  22. ncbi request reprint Role of thyroglobulin in the pathogenesis of Graves' ophthalmopathy: the hypothesis of Kriss revisited
    M Marino
    Department of Endocrinology, University of Pisa, Italy
    J Endocrinol Invest 27:230-6. 2004
    ..Our current view is that, provided that Tg plays a role, it is unlikely the only factor involved and Tg in orbital tissues may rather reinforce or worsen a damage initiated by other mechanisms...
  23. ncbi request reprint Increased prevalence of primary hyperparathyroidism in treated breast cancer
    P Fierabracci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 24:315-20. 2001
    ..We suggest that serum PTH should be determined in all BC patients with increased serum calcium concentration, especially in those with no evidence of metastatic disease...
  24. ncbi request reprint Different somatic alterations of the HRPT2 gene in a patient with recurrent sporadic primary hyperparathyroidism carrying an HRPT2 germline mutation
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 14:493-9. 2007
    ....
  25. ncbi request reprint Novel aspects of immunosuppressive and radiotherapy management of Graves' ophthalmopathy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:272-80. 2004
    ..New data on recently performed placebo-controlled studies on orbital radiotherapy are discussed, together with studies on long-term safety of orbital radiotherapy...
  26. ncbi request reprint Autoimmune hepatitis during intravenous glucocorticoid pulse therapy for Graves' ophthalmopathy treated successfully with glucocorticoids themselves
    M Marino
    Department of Endocrinology, University Hospital of Pisa, Pisa, Italy
    J Endocrinol Invest 28:280-4. 2005
    ..Complete normalization was achieved two months later, while the patient was still receiving a low maintenance dose of oral prednisone...
  27. ncbi request reprint Management of Graves' ophthalmopathy: reality and perspectives
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Italy
    Endocr Rev 21:168-99. 2000
    ..In addition, thyroid ablation may prove beneficial for the ophthalmopathy in view of the pathogenetic model relating eye disease to autoimmune reactions directed against antigens shared by the thyroid and the orbit...
  28. ncbi request reprint High-intensity focused ultrasound as an alternative to the surgical approach in primary hyperparathyroidism: a preliminary experience
    C E Ambrosini
    Department of Surgery, University of Pisa, Via Paradisa, Pisa, Italy
    J Endocrinol Invest 34:655-9. 2011
    ..Recently, high-intensity focused ultrasound (HIFU), a totally non-invasive technique, has become available to cure solid tumors...
  29. doi request reprint Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Endocrinol Invest 34:e200-3. 2011
    ..The aim of the study was to evaluate whether vitamin D [25-(OH) D3] status affects serum IGFI concentrations in healthy subjects...
  30. ncbi request reprint Effects of hormonal replacement treatment on bone mineral density and metabolism in hypogonadal patients
    D Canale
    Dipartimento di Endocrinologia, Universita di Pisa, Ospedale di Cisanello, Via Paradisa, 2, 56124, Pisa, Italy
    Mol Cell Endocrinol 161:47-51. 2000
    ..71, P<0.005 for the vertebrae, and r=0.60, P<0.01 for the femur. A weak correlation was also present between onset of HRT and BMD: r=0.6, P<0.01 at the lumbar level, and r=0.47, P<0.05 at the femoral neck...
  31. ncbi request reprint Molecular pathogenesis of primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 34:35-9. 2011
    ..FHH and NSHPT represent the mildest and severest variants of PHPT, caused by heterozygous and homozygous mutations in the calcium sensing receptor (CASR) gene, respectively...
  32. ncbi request reprint Poorly specific binding of thyroglobulin to orbital fibroblasts from patients with Graves' ophthalmopathy
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 28:420-4. 2005
    ..Because no appreciable inhibition of binding of biotin-labeled Tg was produced by unlabeled Tg, we concluded that binding was poorly specific and it is unlikely to be involved in the pathogenesis of GO...
  33. ncbi request reprint Kidney abnormalities in low density lipoprotein receptor associated protein knockout mice
    S Lisi
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Endocrinol Invest 31:57-61. 2008
    ..Therefore, we concluded that disruption of the RAP gene determines not only thyroid abnormalities, but also a severe defect of megalin expression and function in the kidney...
  34. doi request reprint Is the risk of primary hyperparathyroidism increased in patients with untreated breast cancer?
    V Belardi
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Endocrinol Invest 36:321-5. 2013
    ..An increased frequency of primary hyperparathyroidism (PHP) has been reported in patients with treated breast cancer (BC). PHP has been found in about 7% of BC patients after surgery and radio-, chemio- or hormonal therapy...
  35. ncbi request reprint A quick intraoperative parathyroid hormone assay in the surgical management of patients with primary hyperparathyroidism: a study of 206 consecutive cases
    E Vignali
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 146:783-8. 2002
    ..The traditional surgical approach for patients with primary hyperparathyroidism (PHPT) consists of the identification of at least four glands and in the removal of all hyperfunctioning parathyroid tissue...
  36. doi request reprint Efficacy and safety of three different cumulative doses of intravenous methylprednisolone for moderate to severe and active Graves' orbitopathy
    L Bartalena
    Department of Clinical and Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, 21100 Varese, Italy
    J Clin Endocrinol Metab 97:4454-63. 2012
    ..Optimal doses of i.v. glucocorticoids for Graves' orbitopathy (GO) are undefined...
  37. ncbi request reprint Minimally invasive surgery for thyroid small nodules: preliminary report
    P Miccoli
    Surgery Department, University of Pisa, Italy
    J Endocrinol Invest 22:849-51. 1999
    ..No complications were registered. Cosmetical result was excellent in all patients. MIVA hemythyroidectomy is safe and effective; indications and limits of this new procedure require further studies...
  38. ncbi request reprint A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis
    F Cetani
    Dipartimento di Endocrinologia e Metabolismo, Universita degli Studi di Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:4747-52. 2001
    ..The G228W mutation acts in a dominant fashion and may shed light on the structure-function relationship of the autoimmune regulator protein...
  39. ncbi request reprint The role of PPARĪ³ for the osteoblastic differentiation
    G Viccica
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Endocrinol Invest 33:9-12. 2010
    ..Moreover, the modulation of the PPARĪ³ expression is also implicated in the effects of mechanical loading on bone and in age-related bone loss...
  40. ncbi request reprint Soluble interleukin-1 receptor antagonist concentration in patients with Graves' ophthalmopathy is neither related to cigarette smoking nor predictive of subsequent response to glucocorticoids
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 52:647-51. 2000
    ..The aim of the present study was to evaluate serum soluble interleukin-1 receptor antagonist (sIL-1RA) concentration and its relationship with the degree of cigarette smoking in patients with Graves' ophthalmopathy (GO)...
  41. ncbi request reprint Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:1105-10. 2003
    ..Therefore, we concluded that RAP is involved in Tg secretion by FRTL-5 cells suggesting that RAP may function as a Tg molecular chaperone...
  42. ncbi request reprint Post-menopausal osteoporosis: is it an autoimmune disease?
    E Ambrogini
    Department of Endocrinology and Metabolism, University of Pisa, Pisa Italy
    J Endocrinol Invest 28:43-7. 2005
    ..The protective role of estrogen on bone loss is mediated by type beta transforming growth factor (TGF-beta), which blocks T-cell activation and T-cell TNF-alpha production by repressing antigen presentation...
  43. ncbi request reprint Primary hyperparathyroidism is associated with an impaired secretion of growth hormone but not of the other anterior pituitary hormones
    E Cecconi
    Department of Endocrinology, University of Pisa, Italy
    J Endocrinol Invest 25:RC7-9. 2002
    ..Thus, PHP is associated with an impaired secretion of GH, but not of the other anterior pituitary hormones. The reason why only GH secretion is affected in PHP is unknown...
  44. ncbi request reprint Role of the cholesterol biosynthetic pathway in osteoblastic differentiation
    G Viccica
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 30:8-12. 2007
    ....