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Genomes and Genes | Piero MarchettiSummaryAffiliation: University of Pisa Country: Italy Publications
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Publications
The beta-cell in human type 2 diabetesPiero Marchetti
Department of Endocrinology and Metabolism, Cisanello Hospital, 56124 Pisa, Italy
Adv Exp Med Biol 654:501-14. 2010..Encouraging, although preliminary, data show that some of these defects might be directly counteracted, at least in part, by appropriate in vitro pharmacological intervention...
New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003Jaime Davidson
Endocrine and Diabetes Association of Texas, Dallas, TX, USA
Transplantation 75:SS3-24. 2003- Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metforminPiero Marchetti
Department of Endocrinology and Metabolism and Diabetes, Transplant Unit, University of Pisa, Italy
J Clin Endocrinol Metab 89:5535-41. 2004..Thus, T2D islets have several functional and survival defects, which can be ameliorated by metformin; the beneficial effects of the drug are mediated, at least in part, by a reduction of oxidative stress... - An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatmentPiero Marchetti
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
Regul Pept 146:4-11. 2008..Interestingly, however, pharmacological intervention can improve several defects of Type 2 diabetes islet cells in vitro, suggesting that progression of the disease might not be relentless... - The metabolic effects of cyclosporin and tacrolimusP Marchetti
Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Italy
J Endocrinol Invest 23:482-90. 2000.... - New-onset diabetes after liver transplantation: from pathogenesis to managementPiero Marchetti
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
Liver Transpl 11:612-20. 2005..In conclusion, prospective trials are necessary to properly define antidiabetic therapy and immunosuppressive strategies in this population... - New-onset diabetes after transplantationPiero Marchetti
Dipartimento di Endocrinologia e Metabolismo, Ospedale Cisanello, Pisa, Italy
J Heart Lung Transplant 23:S194-201. 2004..These management approaches should help to lower the risk of new-onset diabetes after heart transplantation and reduce the possible long-term consequences of the condition... - The pancreatic beta-cell in human Type 2 diabetesPiero Marchetti
Department of Endocrinology and Metabolism, Metabolic Section, University of Pisa, Pisa, Italy
Nutr Metab Cardiovasc Dis 16:S3-6. 2006..There is growing evidence that the beta-cell is central to the development of Type 2 diabetes. In this brief review we discuss the factors predisposing to beta-cell dysfunction and some characteristics of islet cells in Type 2 diabetes... - The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patientsP Marchetti
Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, University of Pisa, Via Paradisa 2, 56100, Pisa, Italy
Diabetologia 50:2486-94. 2007..Since ER stress has been associated with beta cell dysfunction, we studied several features of beta cell ER in human type 2 diabetes... - Autophagy and the pancreatic beta-cell in human type 2 diabetesPiero Marchetti
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Autophagy 5:1055-6. 2009.... - Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphismPiero Marchetti
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
Diabetes 51:1419-24. 2002..These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1... - Long-term (5 years) efficacy and safety of pancreas transplantation alone in type 1 diabetic patientsUgo Boggi
Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
Transplantation 93:842-6. 2012.... - Efficacy and safety of basiliximab in kidney transplantationUgo Boggi
Division of Surgery in Uremic and Diabetic Patients General and Transplant Surgery, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
Expert Opin Drug Saf 4:473-90. 2005..However, life-threatening reactions were reported following re-exposure to basiliximab in recipients who lost graft function early after transplantation and, therefore, discontinued all immunosuppressive agents... - Functional and molecular defects of pancreatic islets in human type 2 diabetesSilvia Del Guerra
Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy
Diabetes 54:727-35. 2005..In this regard, it is suggested that reducing islet cell oxidative stress is a potential target of human type 2 diabetes therapy... - Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patientsRoberto Lupi
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
Diabetes Metab Res Rev 20:246-51. 2004.... - The direct effects of tacrolimus and cyclosporin A on isolated human islets: A functional, survival and gene expression studyMarco Bugliani
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Islets 1:106-10. 2009..In conclusion, Tac and CsA affect features of beta-cell differently, with several changes occurring at the molecular level... - The beneficial effects of pancreas transplant alone on diabetic nephropathyAlberto Coppelli
Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56100 Pisa, Italy
Diabetes Care 28:1366-70. 2005..None of these changes occurred in the nontransplanted group. CONCLUSIONS: Successful pancreas transplant alone, through restoration of sustained normoglycemia, improves diabetic nephropathy in type 1 diabetic patients... - Lipotoxicity in human pancreatic islets and the protective effect of metforminRoberto Lupi
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
Diabetes 51:S134-7. 2002..Metformin prevents these deleterious effects, supporting a direct protective action on human beta-cells... - The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic isletsRoberto Lupi
Metabolic Unit, Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56100 Pisa, Italy
Eur J Endocrinol 154:355-61. 2006..Together, these findings provide evidence that the possible beneficial effects of ACE inhibitors in human diabetes are due, at least in part, to a protective action on pancreatic beta-cells... - Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulatedRoberto Lupi
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Diabetes 51:1437-42. 2002..The cytostatic action is likely to be due to the FFA-induced reduction of intraislet glucose metabolism, and the proapoptotic effects are mostly caspase mediated, partially dependent on ceramide pathway, and possibly Bcl-2 regulated... - Beneficial effect of the nonpeptidyl low molecular weight radical scavenger IAC on cultured human islet functionRita Mancarella
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
Cell Transplant 17:1271-6. 2008..We found that IAC markedly reduced oxidative stress and ameliorated islets function. These results suggest that the use of IAC could be an interesting pharmacological approach for the treatment of the islets before transplantation... - Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case reportMariella Tancredi
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Islets 3:231-3. 2011..These findings suggest that in this case of human GD there might mainly be a defect of β-cell amount, not due to increased apoptosis, but possibly to insufficient regeneration... - Effects of pancreas-kidney transplantation on diabetic retinopathyRosa Giannarelli
Department of Endocrinology and Metabolism-Metabolic Unit, University of Pisa, I-56121, Pisa, Italy
Transpl Int 18:619-22. 2005..In conclusion, despite a relatively short follow-up period, successful PTx in our cohort of patients was associated with improvement and/or stabilization of DR in the majority of recipients... - Transplantation of the pancreasUgo Boggi
Division of General and Transplant Surgery, Azienda Ospedaliera Universitaria Pisana, Universita di Pisa, Via Paradisa 2, 56124, Pisa, Italy
Curr Diab Rep 12:568-79. 2012..Refinements in graft preservation, surgical techniques, immunosuppression, and prophylactic treatments are expected to further improve the results of pancreas transplantation... - The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic isletsLorella Marselli
Dipartimento di Endocrinologia e Metabolismo, Sezione Metabolismo, Universita di Pisa, Via Paradisa 2, Ospedale Cisanello, 56100 Pisa, Italy
Eur J Endocrinol 151:207-14. 2004..We hypothesized that PBRs can have a role in human islet physiopathology, and evaluated the effects of prolonged exposure to two specific PBR ligands, PK11195 and Ro5-4864 on the function and survival of isolated human islets... - Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human isletsSilvia Del Guerra
Metabolic Unit, Department of Endocrinology and Metabolism, Cisanello Hospital Pisa, Pisa 56100, Italy
J Diabetes Complications 19:60-4. 2005..In conclusion, prolonged exposure of human islets to different sulphonylureas causes different disturbances of islet cell function, with glimepiride showing milder effects, as compared with chlorpropamide and glibenclamide... - Pancreas transplant alone determines early improvement of cardiovascular risk factors and cardiac function in type 1 diabetic patientsAlberto Coppelli
Department of Endocrinology and Metabolism, Metabolic Unit, Cisanello Hospital-Pisa University, Pisa, Italy
Transplantation 76:974-6. 2003..None of the measured parameters changed in the control patients. CONCLUSIONS: PTA with portal drainage induces an early improvement of CRF and ameliorates cardiac function in patients with T1DM... - Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes modelMichela Novelli
Dipartimento di Patologia Sperimentale, University of Pisa, Pisa, Italy
Pancreas 35:e10-7. 2007.... - Effects of C-peptide on isolated human pancreatic islet cellsMarco Bugliani
Department of Endocrinology and Metabolism Metabolic Unit, University of Pisa, Pisa, Italy
Diabetes Metab Res Rev 23:215-9. 2007..Recent data have demonstrated that pro-insulin-derived C-peptide can affect the function of several different cell types. We hypothesized that C-peptide might have an influence on the function and survival of isolated human islets... - Laparoscopic robot-assisted pancreas transplantation: first world experienceUgo Boggi
Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy
Transplantation 93:201-6. 2012..The da Vinci surgical system, a computer-assisted electromechanical device, provides the unique opportunity to test whether laparoscopy can reduce the morbidity of pancreas transplantation... - Hepatitis C virus infection and human pancreatic beta-cell dysfunctionMatilde Masini
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa and Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
Diabetes Care 28:940-1. 2005 
Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic isletsLuisa Martino
Department of Experimental Pathology, University of Pisa, Pisa, Italy
PLoS ONE 7:e36188. 2012....- Current perspectives on laparoscopic robot-assisted pancreas and pancreas-kidney transplantationUgo Boggi
Division of General and Transplant Surgery, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
Rev Diabet Stud 8:28-34. 2011..There is no proof that progressive graft warming produces actual damage to transplanted organs, unless exceedingly long. However, this important question is likely to elicit a vibrant discussion in the transplant community... - Surgical techniques for pancreas transplantationUgo Boggi
Division of General and Transplant Surgery in Uremic and Diabetic Patientss, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
Curr Opin Organ Transplant 15:102-11. 2010..The purpose of this review is to examine recent surgical advances and discuss their contribution to improved graft function... - A role for autophagy in β-cell life and deathMatilde Masini
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Islets 1:157-9. 2009.... - Results of pancreas transplantation alone with special attention to native kidney function and proteinuria in type 1 diabetes patientsUgo Boggi
Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
Rev Diabet Stud 8:259-67. 2011..Further improvements were recorded in several cardiovascular risk factors, retinopathy, and neuropathy. We conclude that PTA was an effective and reasonably safe procedure in this single-center experience... - A benefit-risk assessment of basiliximab in renal transplantationUgo Boggi
Division of General Surgery and Transplants, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
Drug Saf 27:91-106. 2004.... - A technique for retroperitoneal pancreas transplantation with portal-enteric drainageUgo Boggi
Divisione di Chirurgia Generale e Trapianti, Universita di Pisa, Ospedale di Cisanello, Pisa, Italy
Transplantation 79:1137-42. 2005..We describe a new technique that circumvents these difficulties... - Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetesPiero Marchetti
Department of Clinical and Experimental Medicine, University of Pisa, Cisanello AOUP University Hospital, Pisa, Italy
Intern Emerg Med 8:S55-6. 2013.... - Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunctionMarco Bugliani
Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa 56124, Italy
Mol Cell Endocrinol 367:1-10. 2013..These results show the presence of many changes in islet transcriptome in T2D islets and underline the importance of the association between UPS alterations and beta cell dysfunction in human T2D... - Pancreas preservation with University of Wisconsin and Celsior solutions: a single-center, prospective, randomized pilot studyUgo Boggi
Divisione di Chirurgia Generale e Trapianti, Dipartimento di Oncologia, Trapianti e Nuove Tecnologie in Medicina, Universita di Pisa, Pisa, Italy
Transplantation 77:1186-90. 2004..We report the results of a single-center, prospective, randomized pilot study specifically designed to compare the safety profile of Celsior solution with University of Wisconsin (UW) solution in clinical pancreas transplantation... - Is tacrolimus associated with fewer surgical complications than ciclosporin after kidney-pancreas transplantation?Ugo Boggi
Divisione di Chirurgia nell Uremico e nel Diabetico Chirurgia Generale e Trapiantologica Università di Pisa Ospedale di Cisanello, Via Paradisa 2, 56124, Pisa, Italy
Nat Clin Pract Nephrol 1:76-7. 2005 - Follow-up of secondary diabetic complications after pancreas transplantationUgo Boggi
Division of General and Transplant Surgery, University of Pisa, Pisa, Italy
Curr Opin Organ Transplant 18:102-10. 2013..We herein review the available literature to define the impact of pancreas transplantation on chronic complications of diabetes mellitus... - Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetesMatilde Masini
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Scuola Medica, 56126 Pisa, Italy
Acta Diabetol 49:S247-52. 2012..In conclusion, we detected significant changes in the intracellular distribution of insulin secretory granules within the beta cell that might be related with the alterations in insulin secretion observed in type 2 diabetes patients... - beta-cell function and anti-diabetic pharmacotherapyStefano Del Prato
Department of Endocrinology and Metabolism, Section of Diabetes and Metabolic Diseases, University of Pisa, Pisa, Italy
Diabetes Metab Res Rev 23:518-27. 2007..Moreover, promising future approaches aiming at preserving beta-cell function and mass are discussed... - Prolonged in vitro exposure to autoantibodies against CD38 impairs the function and survival of human pancreatic isletsPiero Marchetti
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Diabetes 51:S474-7. 2002..9 +/- 0.4, P < 0.01). We conclude that prolonged exposure of human islets to sera positive for the presence of CD38Abs with [Ca(2+)](i)-mobilizing activity impairs beta-cell function and viability in cultured human pancreatic islets... - Zinc transporter 8 autoantibodies increase the predictive value of islet autoantibodies for function loss of technically successful solitary pancreas transplantMargherita Occhipinti
Department of Endocrinology and Metabolism, Cisanello University Hospital, Pisa, Italy
Transplantation 92:674-7. 2011..Despite the success rate of solitary pancreas transplantation in type 1 diabetes with preserved kidney function has greatly improved in recent years, a residual proportion of failures persists... - The pancreatic beta cells in human type 2 diabetesPiero Marchetti
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Adv Exp Med Biol 771:288-309. 2012..Continuous improvements in our knowledge of the beta cells in human Type 2 diabetes will lead to more targeted and effective strategies for the prevention and treatment of the disease... - Segmental live donor pancreas transplantation: review and critique of rationale, outcomes, and current recommendationsUgo Boggi
Divisione di Chirurgia Generale e Trapianti nell Uremico e nel Diabetico, Università di Pisa e Azienda Ospedaliero Universitaria, Pisana, Pisa, Italy
Clin Transplant 25:4-12. 2011..Furthermore, LD allows recipient pre-conditioning and/or pair donor exchange. In conclusion, LD PTx may offer significant advantages to well-selected diabetic recipients. LDs are exposed to relatively small risks... - Early improvement of unstable diabetic retinopathy after solitary pancreas transplantationRosa Giannarelli
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Italy
Diabetes Care 25:2358-9. 2002 - Phasic insulin release and metabolic regulation in type 2 diabetesStefano Del Prato
Department of Endocrinology and Metabolism, Section of Diabetes, University of Pisa, Pisa, Italy
Diabetes 51:S109-16. 2002..In type 2 diabetes, loss of the early surge of insulin release is an early and quite common defect that may have a pathogenetic role in the development of postprandial hyperglycemia, possibly requiring specific therapeutic intervention... - NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugsVincenzo Calderone
Dipartimento di Psichiatria, Neurobiologia, Farmacologia, Biotecnologie, Universita di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
Bioorg Med Chem 17:5426-32. 2009.... - From genotype to human β cell phenotype and beyondPiero Marchetti
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Islets 4:323-32. 2012.... - Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable isletsPaul De Vos
Immunoendocrinology, Dept of Pathology and Laboratory Medicine, Section of Medical Biology, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
Trends Mol Med 8:363-6. 2002..The advantages and pitfalls of the approaches developed so far are discussed and compared, together with some recent progress, in view of applicability in clinical islet transplantation... - A simplified technique for the en bloc procurement of abdominal organs that is suitable for pancreas and small-bowel transplantationUgo Boggi
Divisione di Chirurgia Generale e Trapianti, Dipartimento di Oncologia, Trapianti e Nuove Tecnologie in Medicina, , and U.O. Nefrologia e Trapianti, Azienda Ospedaliera Pisana, Italy
Surgery 135:629-41. 2004..CONCLUSIONS: This procurement method has high yields, allows pancreas and small-bowel procurement, and can be learned readily... - Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?Nils Welsh
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Diabetes 54:3238-44. 2005..This makes it unlikely that locally produced IL-1beta is an important mediator of glucotoxicity to human islets and argues against the IL-1beta-NF-kappaB-Fas pathway as a common mediator for beta-cell death in type 1 and type 2 diabetes... - Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cellsFrancesco Andreozzi
Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-Tor Vergata, Rome, Italy
FASEB J 18:959-61. 2004..Increased routing of glucose through this metabolic pathway results in impaired activation of the IR/IRSs/PI3-kinase/Akt survival pathway by induction of O-glycosylation of signaling molecules... - A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjectsGiorgio Sesti
Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115 11800 Catanzaro, Italy
Diabetes 52:1280-3. 2003..These results indicate that the common -866G/A polymorphism in the UCP2 gene may contribute to the biological variation of insulin secretion in humans... - Guidelines for the treatment and management of new-onset diabetes after transplantationAlan Wilkinson
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Clin Transplant 19:291-8. 2005.... - Transcription factors of beta-cell differentiation and maturation in isolated human islets: effects of high glucose, high free fatty acids and type 2 diabetesRoberto Lupi
Nutr Metab Cardiovasc Dis 16:e7-8. 2006 - Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patientsFrancesco Dotta
Department of Internal Medicine, Endocrine and Metabolic Sciences, and Biochemistry, University of Siena, 53100 Siena, Italy
Proc Natl Acad Sci U S A 104:5115-20. 2007..These studies provide direct evidence that enterovirus can infect beta cells in patients with type 1 diabetes and that infection is associated with inflammation and functional impairment... - Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetesValeriya Lyssenko
Department of Clinical Sciences, Diabetes and Endocrinology, and Lund University Diabetes Center, Lund University, Malmo, Sweden
J Clin Invest 117:2155-63. 2007..In conclusion, the increased risk of T2D conferred by variants in TCF7L2 involves the enteroinsular axis, enhanced expression of the gene in islets, and impaired insulin secretion... - The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetesGiorgio Sesti
Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia, Viale Europa, località Germaneto, 88100 Catanzaro, Italy
J Clin Endocrinol Metab 91:2334-9. 2006..Several studies suggest that genetic factors may play a role in the different responses to antidiabetic therapy; however, conclusive evidence is still lacking... - The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1Thierry Brun
Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
Hum Mol Genet 17:478-89. 2008..The latter highlights fundamental differences between human and rodent islet physiology and emphasizes the importance of validating results obtained with animal models in human tissues... - Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokinesCarmela Santangelo
National Center for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Rome, Italy
Eur J Endocrinol 152:485-9. 2005.... - Initiation and execution of lipotoxic ER stress in pancreatic beta-cellsDaniel A Cunha
Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
J Cell Sci 121:2308-18. 2008..In conclusion, saturated FFA induce ER stress via ER Ca(2+) depletion. The IRE1 and resulting JNK activation contribute to beta-cell apoptosis. PERK activation by palmitate also contributes to beta-cell apoptosis via CHOP... - Myalgia: an uncommon or underestimated side effect of mycophenolate mophetil after transplantation?Giorgina B Piccoli
Nephrol Dial Transplant 19:1940-2. 2004 - Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cellsFrancesco Andreozzi
Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
Endocrinology 145:2845-57. 2004..These changes result in impaired coupling of IRS-1 and PI 3-kinase, and activation of the Akt/mammalian target of rapamycin/phosphorylated heat- and acid-stable protein-1/p70S6 kinase pathway... - The grafted kidney takes over: disappearance of the nephrotic syndrome after preemptive pancreas-kidney and kidney transplantation in diabetic nephropathyGiorgina Barbara Piccoli
Department of Nephrology, Department of Internal Medicine, University of Turin, Italy
Transplantation 78:627-30. 2004..These data confirm the efficacy of preemptive kidney and kidney-pancreas transplantation in diabetic nephrotic syndrome and indicate that a regulatory hemodynamic effect should be investigated... - Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic isletsM Letizia Trincavelli
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, , Via Bonnanno 6, 56126 Pisa, Italy
J Cell Biochem 84:636-44. 2002..These results suggest a possible role of peripheral benzodiazepine receptors in the organism response to tissue damage associated with inflammatory mediator production... - Solitary pancreas transplantation in Wolfram syndromeAlberto Coppelli
Transplantation 76:1535-6. 2003 - Disappearance of nephrotic syndrome in type 1 diabetic patients following pancreas transplant aloneAlberto Coppelli
Transplantation 81:1067-8. 2006 - Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell lineMarta Menegazzi
Dipartimento di Scienze Morfologiche e Biomediche, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
Int J Biochem Cell Biol 40:1509-21. 2008..Thus, they are potentially valuable for the prevention or limitation of beta-cell loss in diabetes... - Multilayer nanoencapsulation. New approach for immune protection of human pancreatic isletsSilke Krol
Department of Physics, University of Genoa, Via Dodecaneso 33, 16146 Genoa, Italy
Nano Lett 6:1933-9. 2006..In these first measurements the encapsulation with a multilayer nanocapsule was shown to be a possible alternative to the more space-consuming and random islet-trapping microencapsulation...