Piero Marchetti

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. doi The beta-cell in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, Cisanello Hospital, 56124 Pisa, Italy
    Adv Exp Med Biol 654:501-14. 2010
  2. ncbi Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
    Piero Marchetti
    Department of Endocrinology and Metabolism and Diabetes, Transplant Unit, University of Pisa, Italy
    J Clin Endocrinol Metab 89:5535-41. 2004
  3. ncbi An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Regul Pept 146:4-11. 2008
  4. ncbi New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003
    Jaime Davidson
    Endocrine and Diabetes Association of Texas, Dallas, TX, USA
    Transplantation 75:SS3-24. 2003
  5. ncbi The metabolic effects of cyclosporin and tacrolimus
    P Marchetti
    Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Italy
    J Endocrinol Invest 23:482-90. 2000
  6. ncbi The pancreatic beta-cell in human Type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Section, University of Pisa, Pisa, Italy
    Nutr Metab Cardiovasc Dis 16:S3-6. 2006
  7. ncbi Autophagy and the pancreatic beta-cell in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Autophagy 5:1055-6. 2009
  8. ncbi New-onset diabetes after transplantation
    Piero Marchetti
    Dipartimento di Endocrinologia e Metabolismo, Ospedale Cisanello, Pisa, Italy
    J Heart Lung Transplant 23:S194-201. 2004
  9. ncbi The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
    P Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, University of Pisa, Via Paradisa 2, 56100, Pisa, Italy
    Diabetologia 50:2486-94. 2007
  10. ncbi New-onset diabetes after liver transplantation: from pathogenesis to management
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Liver Transpl 11:612-20. 2005

Detail Information

Publications75

  1. doi The beta-cell in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, Cisanello Hospital, 56124 Pisa, Italy
    Adv Exp Med Biol 654:501-14. 2010
    ..Encouraging, although preliminary, data show that some of these defects might be directly counteracted, at least in part, by appropriate in vitro pharmacological intervention...
  2. ncbi Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
    Piero Marchetti
    Department of Endocrinology and Metabolism and Diabetes, Transplant Unit, University of Pisa, Italy
    J Clin Endocrinol Metab 89:5535-41. 2004
    ..Thus, T2D islets have several functional and survival defects, which can be ameliorated by metformin; the beneficial effects of the drug are mediated, at least in part, by a reduction of oxidative stress...
  3. ncbi An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Regul Pept 146:4-11. 2008
    ..Interestingly, however, pharmacological intervention can improve several defects of Type 2 diabetes islet cells in vitro, suggesting that progression of the disease might not be relentless...
  4. ncbi New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003
    Jaime Davidson
    Endocrine and Diabetes Association of Texas, Dallas, TX, USA
    Transplantation 75:SS3-24. 2003
  5. ncbi The metabolic effects of cyclosporin and tacrolimus
    P Marchetti
    Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Italy
    J Endocrinol Invest 23:482-90. 2000
    ....
  6. ncbi The pancreatic beta-cell in human Type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Section, University of Pisa, Pisa, Italy
    Nutr Metab Cardiovasc Dis 16:S3-6. 2006
    ..There is growing evidence that the beta-cell is central to the development of Type 2 diabetes. In this brief review we discuss the factors predisposing to beta-cell dysfunction and some characteristics of islet cells in Type 2 diabetes...
  7. ncbi Autophagy and the pancreatic beta-cell in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Autophagy 5:1055-6. 2009
    ....
  8. ncbi New-onset diabetes after transplantation
    Piero Marchetti
    Dipartimento di Endocrinologia e Metabolismo, Ospedale Cisanello, Pisa, Italy
    J Heart Lung Transplant 23:S194-201. 2004
    ..These management approaches should help to lower the risk of new-onset diabetes after heart transplantation and reduce the possible long-term consequences of the condition...
  9. ncbi The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
    P Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, University of Pisa, Via Paradisa 2, 56100, Pisa, Italy
    Diabetologia 50:2486-94. 2007
    ..Since ER stress has been associated with beta cell dysfunction, we studied several features of beta cell ER in human type 2 diabetes...
  10. ncbi New-onset diabetes after liver transplantation: from pathogenesis to management
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Liver Transpl 11:612-20. 2005
    ..In conclusion, prospective trials are necessary to properly define antidiabetic therapy and immunosuppressive strategies in this population...
  11. ncbi Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes 51:1419-24. 2002
    ..These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1...
  12. doi Long-term (5 years) efficacy and safety of pancreas transplantation alone in type 1 diabetic patients
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Transplantation 93:842-6. 2012
    ....
  13. ncbi Efficacy and safety of basiliximab in kidney transplantation
    Ugo Boggi
    Division of Surgery in Uremic and Diabetic Patients General and Transplant Surgery, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Expert Opin Drug Saf 4:473-90. 2005
    ..However, life-threatening reactions were reported following re-exposure to basiliximab in recipients who lost graft function early after transplantation and, therefore, discontinued all immunosuppressive agents...
  14. ncbi Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    Roberto Lupi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetes 51:1437-42. 2002
    ..The cytostatic action is likely to be due to the FFA-induced reduction of intraislet glucose metabolism, and the proapoptotic effects are mostly caspase mediated, partially dependent on ceramide pathway, and possibly Bcl-2 regulated...
  15. ncbi Functional and molecular defects of pancreatic islets in human type 2 diabetes
    Silvia Del Guerra
    Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Diabetes 54:727-35. 2005
    ..In this regard, it is suggested that reducing islet cell oxidative stress is a potential target of human type 2 diabetes therapy...
  16. doi Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction
    Marco Bugliani
    Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa 56124, Italy
    Mol Cell Endocrinol 367:1-10. 2013
    ..These results show the presence of many changes in islet transcriptome in T2D islets and underline the importance of the association between UPS alterations and beta cell dysfunction in human T2D...
  17. ncbi Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report
    Mariella Tancredi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 3:231-3. 2011
    ..These findings suggest that in this case of human GD there might mainly be a defect of β-cell amount, not due to increased apoptosis, but possibly to insufficient regeneration...
  18. ncbi The beneficial effects of pancreas transplant alone on diabetic nephropathy
    Alberto Coppelli
    Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56100 Pisa, Italy
    Diabetes Care 28:1366-70. 2005
    ..We evaluated whether restoration of long-lasting normoglycemia by pancreas transplant alone might have beneficial action on diabetic nephropathy...
  19. ncbi The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets
    Roberto Lupi
    Metabolic Unit, Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56100 Pisa, Italy
    Eur J Endocrinol 154:355-61. 2006
    ....
  20. ncbi Lipotoxicity in human pancreatic islets and the protective effect of metformin
    Roberto Lupi
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes 51:S134-7. 2002
    ..Metformin prevents these deleterious effects, supporting a direct protective action on human beta-cells...
  21. doi The direct effects of tacrolimus and cyclosporin A on isolated human islets: A functional, survival and gene expression study
    Marco Bugliani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 1:106-10. 2009
    ..In conclusion, Tac and CsA affect features of beta-cell differently, with several changes occurring at the molecular level...
  22. ncbi The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets
    Lorella Marselli
    Dipartimento di Endocrinologia e Metabolismo, Sezione Metabolismo, Universita di Pisa, Via Paradisa 2, Ospedale Cisanello, 56100 Pisa, Italy
    Eur J Endocrinol 151:207-14. 2004
    ..We hypothesized that PBRs can have a role in human islet physiopathology, and evaluated the effects of prolonged exposure to two specific PBR ligands, PK11195 and Ro5-4864 on the function and survival of isolated human islets...
  23. ncbi Beneficial effect of the nonpeptidyl low molecular weight radical scavenger IAC on cultured human islet function
    Rita Mancarella
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Cell Transplant 17:1271-6. 2008
    ..We found that IAC markedly reduced oxidative stress and ameliorated islets function. These results suggest that the use of IAC could be an interesting pharmacological approach for the treatment of the islets before transplantation...
  24. ncbi Effects of pancreas-kidney transplantation on diabetic retinopathy
    Rosa Giannarelli
    Department of Endocrinology and Metabolism Metabolic Unit, University of Pisa, I 56121, Pisa, Italy
    Transpl Int 18:619-22. 2005
    ..In conclusion, despite a relatively short follow-up period, successful PTx in our cohort of patients was associated with improvement and/or stabilization of DR in the majority of recipients...
  25. ncbi Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients
    Roberto Lupi
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes Metab Res Rev 20:246-51. 2004
    ..Type 1 diabetes results from the destruction of pancreatic beta-cell as a consequence of an autoimmune process. To date, information on the properties of islets isolated from type 1 diabetic patients is very scant...
  26. ncbi Transplantation of the pancreas
    Ugo Boggi
    Division of General and Transplant Surgery, Azienda Ospedaliera Universitaria Pisana, Universita di Pisa, Via Paradisa 2, 56124, Pisa, Italy
    Curr Diab Rep 12:568-79. 2012
    ..Refinements in graft preservation, surgical techniques, immunosuppression, and prophylactic treatments are expected to further improve the results of pancreas transplantation...
  27. ncbi Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets
    Silvia Del Guerra
    Metabolic Unit, Department of Endocrinology and Metabolism, Cisanello Hospital Pisa, Pisa 56100, Italy
    J Diabetes Complications 19:60-4. 2005
    ..In conclusion, prolonged exposure of human islets to different sulphonylureas causes different disturbances of islet cell function, with glimepiride showing milder effects, as compared with chlorpropamide and glibenclamide...
  28. ncbi Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model
    Michela Novelli
    Dipartimento di Patologia Sperimentale, University of Pisa, Pisa, Italy
    Pancreas 35:e10-7. 2007
    ....
  29. ncbi Effects of C-peptide on isolated human pancreatic islet cells
    Marco Bugliani
    Department of Endocrinology and Metabolism Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes Metab Res Rev 23:215-9. 2007
    ..Recent data have demonstrated that pro-insulin-derived C-peptide can affect the function of several different cell types. We hypothesized that C-peptide might have an influence on the function and survival of isolated human islets...
  30. doi Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetes
    Piero Marchetti
    Department of Clinical and Experimental Medicine, University of Pisa, Cisanello AOUP University Hospital, Pisa, Italy
    Intern Emerg Med 8:S55-6. 2013
    ....
  31. ncbi Pancreas transplant alone determines early improvement of cardiovascular risk factors and cardiac function in type 1 diabetic patients
    Alberto Coppelli
    Department of Endocrinology and Metabolism, Metabolic Unit, Cisanello Hospital Pisa University, Pisa, Italy
    Transplantation 76:974-6. 2003
    ..The effects of pancreas transplant alone (PTA) on cardiovascular risk factors (CRF) and cardiac function in type 1 diabetes mellitus (T1DM) patients are still unsettled...
  32. doi Laparoscopic robot-assisted pancreas transplantation: first world experience
    Ugo Boggi
    Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy
    Transplantation 93:201-6. 2012
    ..The da Vinci surgical system, a computer-assisted electromechanical device, provides the unique opportunity to test whether laparoscopy can reduce the morbidity of pancreas transplantation...
  33. doi Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes
    Matilde Masini
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Scuola Medica, 56126 Pisa, Italy
    Acta Diabetol 49:S247-52. 2012
    ..In conclusion, we detected significant changes in the intracellular distribution of insulin secretory granules within the beta cell that might be related with the alterations in insulin secretion observed in type 2 diabetes patients...
  34. pmc Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets
    Luisa Martino
    Department of Experimental Pathology, University of Pisa, Pisa, Italy
    PLoS ONE 7:e36188. 2012
    ....
  35. doi Surgical techniques for pancreas transplantation
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patientss, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Curr Opin Organ Transplant 15:102-11. 2010
    ..The purpose of this review is to examine recent surgical advances and discuss their contribution to improved graft function...
  36. pmc Current perspectives on laparoscopic robot-assisted pancreas and pancreas-kidney transplantation
    Ugo Boggi
    Division of General and Transplant Surgery, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
    Rev Diabet Stud 8:28-34. 2011
    ..There is no proof that progressive graft warming produces actual damage to transplanted organs, unless exceedingly long. However, this important question is likely to elicit a vibrant discussion in the transplant community...
  37. doi A role for autophagy in β-cell life and death
    Matilde Masini
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 1:157-9. 2009
    ....
  38. ncbi Pancreas preservation with University of Wisconsin and Celsior solutions: a single-center, prospective, randomized pilot study
    Ugo Boggi
    Divisione di Chirurgia Generale e Trapianti, Dipartimento di Oncologia, Trapianti e Nuove Tecnologie in Medicina, Universita di Pisa, Pisa, Italy
    Transplantation 77:1186-90. 2004
    ..We report the results of a single-center, prospective, randomized pilot study specifically designed to compare the safety profile of Celsior solution with University of Wisconsin (UW) solution in clinical pancreas transplantation...
  39. ncbi Hepatitis C virus infection and human pancreatic beta-cell dysfunction
    Matilde Masini
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa and Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
    Diabetes Care 28:940-1. 2005
  40. pmc Results of pancreas transplantation alone with special attention to native kidney function and proteinuria in type 1 diabetes patients
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Rev Diabet Stud 8:259-67. 2011
    ..Further improvements were recorded in several cardiovascular risk factors, retinopathy, and neuropathy. We conclude that PTA was an effective and reasonably safe procedure in this single-center experience...
  41. ncbi A benefit-risk assessment of basiliximab in renal transplantation
    Ugo Boggi
    Division of General Surgery and Transplants, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Drug Saf 27:91-106. 2004
    ....
  42. ncbi A technique for retroperitoneal pancreas transplantation with portal-enteric drainage
    Ugo Boggi
    Divisione di Chirurgia Generale e Trapianti, Universita di Pisa, Ospedale di Cisanello, Pisa, Italy
    Transplantation 79:1137-42. 2005
    ..We describe a new technique that circumvents these difficulties...
  43. ncbi Is tacrolimus associated with fewer surgical complications than ciclosporin after kidney-pancreas transplantation?
    Ugo Boggi
    Divisione di Chirurgia nell Uremico e nel Diabetico Chirurgia Generale e Trapiantologica Università di Pisa Ospedale di Cisanello, Via Paradisa 2, 56124, Pisa, Italy
    Nat Clin Pract Nephrol 1:76-7. 2005
  44. doi Follow-up of secondary diabetic complications after pancreas transplantation
    Ugo Boggi
    Division of General and Transplant Surgery, University of Pisa, Pisa, Italy
    Curr Opin Organ Transplant 18:102-10. 2013
    ..We herein review the available literature to define the impact of pancreas transplantation on chronic complications of diabetes mellitus...
  45. doi Zinc transporter 8 autoantibodies increase the predictive value of islet autoantibodies for function loss of technically successful solitary pancreas transplant
    Margherita Occhipinti
    Department of Endocrinology and Metabolism, Cisanello University Hospital, Pisa, Italy
    Transplantation 92:674-7. 2011
    ..Despite the success rate of solitary pancreas transplantation in type 1 diabetes with preserved kidney function has greatly improved in recent years, a residual proportion of failures persists...
  46. ncbi beta-cell function and anti-diabetic pharmacotherapy
    Stefano Del Prato
    Department of Endocrinology and Metabolism, Section of Diabetes and Metabolic Diseases, University of Pisa, Pisa, Italy
    Diabetes Metab Res Rev 23:518-27. 2007
    ..Moreover, promising future approaches aiming at preserving beta-cell function and mass are discussed...
  47. ncbi Prolonged in vitro exposure to autoantibodies against CD38 impairs the function and survival of human pancreatic islets
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetes 51:S474-7. 2002
    ..9 +/- 0.4, P < 0.01). We conclude that prolonged exposure of human islets to sera positive for the presence of CD38Abs with [Ca(2+)](i)-mobilizing activity impairs beta-cell function and viability in cultured human pancreatic islets...
  48. ncbi The pancreatic beta cells in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Adv Exp Med Biol 771:288-309. 2012
    ..Continuous improvements in our knowledge of the beta cells in human Type 2 diabetes will lead to more targeted and effective strategies for the prevention and treatment of the disease...
  49. doi Segmental live donor pancreas transplantation: review and critique of rationale, outcomes, and current recommendations
    Ugo Boggi
    Divisione di Chirurgia Generale e Trapianti nell Uremico e nel Diabetico, Università di Pisa e Azienda Ospedaliero Universitaria, Pisana, Pisa, Italy
    Clin Transplant 25:4-12. 2011
    ..Furthermore, LD allows recipient pre-conditioning and/or pair donor exchange. In conclusion, LD PTx may offer significant advantages to well-selected diabetic recipients. LDs are exposed to relatively small risks...
  50. ncbi Early improvement of unstable diabetic retinopathy after solitary pancreas transplantation
    Rosa Giannarelli
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Italy
    Diabetes Care 25:2358-9. 2002
  51. ncbi Phasic insulin release and metabolic regulation in type 2 diabetes
    Stefano Del Prato
    Department of Endocrinology and Metabolism, Section of Diabetes, University of Pisa, Pisa, Italy
    Diabetes 51:S109-16. 2002
    ..In type 2 diabetes, loss of the early surge of insulin release is an early and quite common defect that may have a pathogenetic role in the development of postprandial hyperglycemia, possibly requiring specific therapeutic intervention...
  52. doi NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia, Biotecnologie, Universita di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Bioorg Med Chem 17:5426-32. 2009
    ....
  53. pmc From genotype to human β cell phenotype and beyond
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 4:323-32. 2012
    ....
  54. ncbi Myalgia: an uncommon or underestimated side effect of mycophenolate mophetil after transplantation?
    Giorgina B Piccoli
    Nephrol Dial Transplant 19:1940-2. 2004
  55. ncbi Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable islets
    Paul De Vos
    Immunoendocrinology, Dept of Pathology and Laboratory Medicine, Section of Medical Biology, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Trends Mol Med 8:363-6. 2002
    ..The advantages and pitfalls of the approaches developed so far are discussed and compared, together with some recent progress, in view of applicability in clinical islet transplantation...
  56. ncbi Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines
    Carmela Santangelo
    National Center for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Rome, Italy
    Eur J Endocrinol 152:485-9. 2005
    ....
  57. ncbi Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
    Nils Welsh
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 54:3238-44. 2005
    ..This makes it unlikely that locally produced IL-1beta is an important mediator of glucotoxicity to human islets and argues against the IL-1beta-NF-kappaB-Fas pathway as a common mediator for beta-cell death in type 1 and type 2 diabetes...
  58. ncbi Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells
    Cristina D'Alessandris
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    FASEB J 18:959-61. 2004
    ..Increased routing of glucose through this metabolic pathway results in impaired activation of the IR/IRSs/PI3-kinase/Akt survival pathway by induction of O-glycosylation of signaling molecules...
  59. ncbi Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells
    Francesco Andreozzi
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
    Endocrinology 145:2845-57. 2004
    ..These changes result in impaired coupling of IRS-1 and PI 3-kinase, and activation of the Akt/mammalian target of rapamycin/phosphorylated heat- and acid-stable protein-1/p70S6 kinase pathway...
  60. ncbi A simplified technique for the en bloc procurement of abdominal organs that is suitable for pancreas and small-bowel transplantation
    Ugo Boggi
    Divisione di Chirurgia Generale e Trapianti, Dipartimento di Oncologia, Trapianti e Nuove Tecnologie in Medicina, Universita di Pisa, and U O Nefrologia e Trapianti, Azienda Ospedaliera Pisana, Italy
    Surgery 135:629-41. 2004
    ..We describe the results of a simplified method for the en bloc procurement of multiple organs, which permits isolated transplantation of all abdominal grafts, including the pancreas and the small bowel, to different recipients...
  61. ncbi Transcription factors of beta-cell differentiation and maturation in isolated human islets: effects of high glucose, high free fatty acids and type 2 diabetes
    Roberto Lupi
    Nutr Metab Cardiovasc Dis 16:e7-8. 2006
  62. pmc Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
    Francesco Dotta
    Department of Internal Medicine, Endocrine and Metabolic Sciences, and Biochemistry, University of Siena, 53100 Siena, Italy
    Proc Natl Acad Sci U S A 104:5115-20. 2007
    ..These studies provide direct evidence that enterovirus can infect beta cells in patients with type 1 diabetes and that infection is associated with inflammation and functional impairment...
  63. ncbi The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia, Viale Europa, località Germaneto, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 91:2334-9. 2006
    ..Several studies suggest that genetic factors may play a role in the different responses to antidiabetic therapy; however, conclusive evidence is still lacking...
  64. ncbi The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1
    Thierry Brun
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    Hum Mol Genet 17:478-89. 2008
    ..The latter highlights fundamental differences between human and rodent islet physiology and emphasizes the importance of validating results obtained with animal models in human tissues...
  65. pmc Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, and Lund University Diabetes Center, Lund University, Malmo, Sweden
    J Clin Invest 117:2155-63. 2007
    ..In conclusion, the increased risk of T2D conferred by variants in TCF7L2 involves the enteroinsular axis, enhanced expression of the gene in islets, and impaired insulin secretion...
  66. pmc Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
    Daniel A Cunha
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    J Cell Sci 121:2308-18. 2008
    ..In conclusion, saturated FFA induce ER stress via ER Ca(2+) depletion. The IRE1 and resulting JNK activation contribute to beta-cell apoptosis. PERK activation by palmitate also contributes to beta-cell apoptosis via CHOP...
  67. ncbi Guidelines for the treatment and management of new-onset diabetes after transplantation
    Alan Wilkinson
    David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Clin Transplant 19:291-8. 2005
    ....
  68. ncbi A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115 11800 Catanzaro, Italy
    Diabetes 52:1280-3. 2003
    ..These results indicate that the common -866G/A polymorphism in the UCP2 gene may contribute to the biological variation of insulin secretion in humans...
  69. ncbi Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic islets
    M Letizia Trincavelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonnanno 6, 56126 Pisa, Italy
    J Cell Biochem 84:636-44. 2002
    ..These results suggest a possible role of peripheral benzodiazepine receptors in the organism response to tissue damage associated with inflammatory mediator production...
  70. ncbi The grafted kidney takes over: disappearance of the nephrotic syndrome after preemptive pancreas-kidney and kidney transplantation in diabetic nephropathy
    Giorgina Barbara Piccoli
    Department of Nephrology, Department of Internal Medicine, University of Turin, Italy
    Transplantation 78:627-30. 2004
    ..These data confirm the efficacy of preemptive kidney and kidney-pancreas transplantation in diabetic nephrotic syndrome and indicate that a regulatory hemodynamic effect should be investigated...
  71. ncbi Disappearance of nephrotic syndrome in type 1 diabetic patients following pancreas transplant alone
    Alberto Coppelli
    Transplantation 81:1067-8. 2006
  72. ncbi Multilayer nanoencapsulation. New approach for immune protection of human pancreatic islets
    Silke Krol
    Department of Physics, University of Genoa, Via Dodecaneso 33, 16146 Genoa, Italy
    Nano Lett 6:1933-9. 2006
    ..In these first measurements the encapsulation with a multilayer nanocapsule was shown to be a possible alternative to the more space-consuming and random islet-trapping microencapsulation...
  73. ncbi Solitary pancreas transplantation in Wolfram syndrome
    Alberto Coppelli
    Transplantation 76:1535-6. 2003
  74. doi Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line
    Marta Menegazzi
    Dipartimento di Scienze Morfologiche e Biomediche, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Int J Biochem Cell Biol 40:1509-21. 2008
    ..Thus, they are potentially valuable for the prevention or limitation of beta-cell loss in diabetes...