Giulia Marchetti

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Interleukin-2 immunotherapy exerts a differential effect on CD4 and CD8 T cell dynamics
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Italy
    AIDS 18:211-6. 2004
  2. ncbi request reprint Partial immune reconstitution following highly active antiretroviral therapy: can adjuvant interleukin-2 fill the gap?
    Giulia Marchetti
    Institute of Infectious Disease and Tropical Medicine, University of Milan, Luigi Sacco Hospital, Milan, Italy
    J Antimicrob Chemother 55:401-9. 2005
  3. doi request reprint Serum alpha-fetoprotein levels predict early virologic response in HIV-positive subjects treated for chronic hepatitis C
    Marco Bongiovanni
    J Acquir Immune Defic Syndr 48:361-3. 2008
  4. pmc Role of in vitro stimulation with lipopolysaccharide on T-cell activation in HIV-infected antiretroviral-treated patients
    Camilla Tincati
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Via A Di Rudini 8, 20142 Milan, Italy
    Clin Dev Immunol 2012:935425. 2012
  5. pmc Evidence for polymicrobic flora translocating in peripheral blood of HIV-infected patients with poor immune response to antiretroviral therapy
    Esther Merlini
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    PLoS ONE 6:e18580. 2011
  6. pmc T-cell phenotypes, apoptosis and inflammation in HIV+ patients on virologically effective cART with early atherosclerosis
    Esther Merlini
    Clinic of Infectious Diseases and Tropical Medicine, Department of Health Sciences, University of Milan, San Paolo Hospital, Italy
    PLoS ONE 7:e46073. 2012
  7. pmc Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy
    Giusi Maria Bellistri
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    PLoS ONE 5:e15663. 2010
  8. doi request reprint Immune activation and microbial translocation in liver disease progression in HIV/hepatitis co-infected patients: results from the Icona Foundation study
    Giulia Marchetti
    Department of Health Sciences Clinic of Infectious Diseases San Paolo Hospital, University of Milan, Via A, Di Rudinì, 8 20142 Milan, Italy
    BMC Infect Dis 14:79. 2014
  9. ncbi request reprint Immune reconstitution in HIV+ subjects on lopinavir/ritonavir-based HAART according to the severity of pre-therapy CD4+
    Giulia Marchetti
    Dept of Medicine, Surgery and Dentistry Clinic of Infectious Diseases San Paolo Hospital University of Milan, Milan, Italy
    Curr HIV Res 10:597-605. 2012
  10. pmc Circulating sCD14 is associated with virological response to pegylated-interferon-alpha/ribavirin treatment in HIV/HCV co-infected patients
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, University of Milan, San Paolo Hospital, Milan, Italy
    PLoS ONE 7:e32028. 2012

Detail Information

Publications36

  1. ncbi request reprint Interleukin-2 immunotherapy exerts a differential effect on CD4 and CD8 T cell dynamics
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Italy
    AIDS 18:211-6. 2004
    ..The hallmark of interleukin-2 (IL-2)-induced immune reconstitution is the selective outgrowth of CD4 through undefined mechanisms...
  2. ncbi request reprint Partial immune reconstitution following highly active antiretroviral therapy: can adjuvant interleukin-2 fill the gap?
    Giulia Marchetti
    Institute of Infectious Disease and Tropical Medicine, University of Milan, Luigi Sacco Hospital, Milan, Italy
    J Antimicrob Chemother 55:401-9. 2005
    ..However, whether or not these immunological effects translate into an actual immunological competency and therefore clinical benefit, still awaits demonstration from ongoing large, controlled clinical studies...
  3. doi request reprint Serum alpha-fetoprotein levels predict early virologic response in HIV-positive subjects treated for chronic hepatitis C
    Marco Bongiovanni
    J Acquir Immune Defic Syndr 48:361-3. 2008
  4. pmc Role of in vitro stimulation with lipopolysaccharide on T-cell activation in HIV-infected antiretroviral-treated patients
    Camilla Tincati
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Via A Di Rudini 8, 20142 Milan, Italy
    Clin Dev Immunol 2012:935425. 2012
    ....
  5. pmc Evidence for polymicrobic flora translocating in peripheral blood of HIV-infected patients with poor immune response to antiretroviral therapy
    Esther Merlini
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    PLoS ONE 6:e18580. 2011
    ..Failure to control microbial translocation on HAART is associated with a polymicrobic flora circulating in peripheral blood that is not substantially modified by therapy...
  6. pmc T-cell phenotypes, apoptosis and inflammation in HIV+ patients on virologically effective cART with early atherosclerosis
    Esther Merlini
    Clinic of Infectious Diseases and Tropical Medicine, Department of Health Sciences, University of Milan, San Paolo Hospital, Italy
    PLoS ONE 7:e46073. 2012
    ....
  7. pmc Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy
    Giusi Maria Bellistri
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    PLoS ONE 5:e15663. 2010
    ....
  8. doi request reprint Immune activation and microbial translocation in liver disease progression in HIV/hepatitis co-infected patients: results from the Icona Foundation study
    Giulia Marchetti
    Department of Health Sciences Clinic of Infectious Diseases San Paolo Hospital, University of Milan, Via A, Di Rudinì, 8 20142 Milan, Italy
    BMC Infect Dis 14:79. 2014
    ..We evaluated whether immune activation (IA) and microbial translocation (MT) might play a role in accelerating liver disease progression in HIV-HBV/HCV co-infected patients...
  9. ncbi request reprint Immune reconstitution in HIV+ subjects on lopinavir/ritonavir-based HAART according to the severity of pre-therapy CD4+
    Giulia Marchetti
    Dept of Medicine, Surgery and Dentistry Clinic of Infectious Diseases San Paolo Hospital University of Milan, Milan, Italy
    Curr HIV Res 10:597-605. 2012
    ..We aimed to assess the impact of TDF/FTC +LPV/r-based HAART on the quality of immune reconstitution and on microbial translocation (MT) in HIV-infected antiretroviral-na�ve late presenting patients...
  10. pmc Circulating sCD14 is associated with virological response to pegylated-interferon-alpha/ribavirin treatment in HIV/HCV co-infected patients
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, University of Milan, San Paolo Hospital, Milan, Italy
    PLoS ONE 7:e32028. 2012
    ..We asked whether increased MT and immune activation may hamper anti-HCV response in HIV/HCV patients...
  11. doi request reprint Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Italy
    AIDS 25:1385-94. 2011
    ..We investigated the significance of microbial translocation measured on average 3 years after HIV seroconversion in driving disease progression in HIV untreated patients with high CD4(+) cell count...
  12. doi request reprint Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    AIDS 24:1455-60. 2010
    ..Analysis of functionally defined T-cell differentiation in HIV-infected patients with low CD4(+) on virologically suppressive HAART is crucial to design clinically efficacious treatments...
  13. doi request reprint HIV-infected long-term nonprogressors display a unique correlative pattern between the interleukin-7/interleukin-7 receptor circuit and T-cell homeostasis
    G Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Via A Di Rudini, Milan 8 20142, Italy
    HIV Med 10:422-31. 2009
    ....
  14. ncbi request reprint Low-dose prolonged intermittent interleukin-2 adjuvant therapy: results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairment
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    J Infect Dis 186:606-16. 2002
    ..Thus, adjuvant IL-2 therapy in immunologic nonresponders resulted in a clinical benefit, suggesting that the quantitative cell recovery involves functionally competent immune cells...
  15. doi request reprint Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    AIDS 22:2035-8. 2008
    ..These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation...
  16. ncbi request reprint The challenge of IL-2 immunotherapy in HIV disease: "no through road" or turning point?
    Giulia Marchetti
    Clinic of Infectious Diseases and Tropical Medicine, Department of Medicine, Surgery and Dentistry, San Paolo Hospital, University of Milan, Milan, Italy
    Curr HIV Res 6:189-99. 2008
    ..This review is meant to thoroughly explore the possibility that the immunological advantages described during IL-2 immunotherapy might translate into actual clinical benefits in the treatment of HIV/AIDS disease...
  17. ncbi request reprint Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART
    Giulia Marchetti
    Department of Clinical Sciences, Chair of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157 Milan, Italy
    AIDS 20:1727-36. 2006
    ..A better understanding of the relationship between T-cell dynamics and the HIV intracellular reservoir in HIV-infected patients failing to recover CD4 cell count following long-term HAART, is required...
  18. ncbi request reprint IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 9:447-52. 2004
    ..Our data confirm the pivotal role of IL-2 and IL-7 in the regulation of T-lymphocyte homeostasis in HIV infection...
  19. ncbi request reprint Early initiation of highly active antiretroviral therapy fails to reverse immunovirological abnormalities in gut-associated lymphoid tissue induced by acute HIV infection
    Camilla Tincati
    Department of Internal Medicine, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Milan, Italy
    Antivir Ther 14:321-30. 2009
    ..During the acute phase of HIV infection, large CD4+ T-cell depletion occurs in the gastrointestinal tract. The kinetics of CD4+ T-cell decrease and highly active antiretroviral therapy (HAART)-mediated immune reconstitution were evaluated...
  20. doi request reprint Reduced CD127 expression on peripheral CD4+ T cells impairs immunological recovery in course of suppressive highly active antiretroviral therapy
    Francesca Bai
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, University of Milan, San Paolo Hospital, Milan, Italy
    AIDS 24:2590-3. 2010
    ..These results suggest a possible role for the IL-7/IL-7R system in the pathogenesis of poor immunological recovery during HAART...
  21. pmc Association between peripheral T-Lymphocyte activation and impaired bone mineral density in HIV-infected patients
    Lidia Gazzola
    Department of Health Sciences, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Via A, Di Rudinì, 8, Milan 20142, Italy
    J Transl Med 11:51. 2013
    ..HIV-infected patients display an increased and early incidence of osteopenia/osteoporosis. We investigated whether bone metabolism disorders in HIV-infected patients are related to immune hyperactivation and premature immune senescence...
  22. doi request reprint Risk of clinical progression among patients with immunological nonresponse despite virological suppression after combination antiretroviral treatment
    Giuseppe Lapadula
    Clinic of Infectious Diseases, San Gerardo de Tintori Hospital, Monza, Italy
    AIDS 27:769-79. 2013
    ..It is unclear whether lack of immunological response despite viral suppression and relatively preserved CD4 T-cell count is associated with increased risk of AIDS or severe non-AIDS events...
  23. ncbi request reprint Immunomodulation induced by tucaresol in HIV infection: results of a 16 week pilot Phase I/II trial
    Andrea Gori
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 9:603-14. 2004
    ..In a Phase I/II clinical trial performed on HIV-positive patients we analysed the safety and immunomodulating effects of tucaresol, a novel compound that has previously been described tn enhance cell-mediated immune responses...
  24. doi request reprint The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options
    Lidia Gazzola
    Department of Medicine, Surgery, and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    Clin Infect Dis 48:328-37. 2009
    ....
  25. doi request reprint CD8 T-cell activation is associated with lipodystrophy and visceral fat accumulation in antiretroviral therapy-treated virologically suppressed HIV-infected patients
    Giovanni Guaraldi
    Department of Medical and Surgical Sciences for Adults and Children, Clinic of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy Department of Medicine, Surgery and Dentistry, Clinic of Infectious and Tropical Diseases, University of Milano, Milan, Italy Serviço de Doenças Infecciosas, Hospital de Joaquim Urbano, Porto, Portugal and Biochimie et Hormonologie, Hôpital Tenon AP HP Paris, CdR Saint Antoine, Inserm U938, Université Paris6 UPMC, Faculte de Medecine Pierre et Marie Curie, Paris, France
    J Acquir Immune Defic Syndr 64:360-6. 2013
    ..Thus, the aim of the study was to search for an association between the presence of clinical lipodystrophy (LD), visceral and subcutaneous abdominal adipose tissue amount (VAT and SAT), and peripheral T-cell immune phenotypes...
  26. ncbi request reprint Successful rescue therapy with a darunavir/ritonavir and etravirine antiretroviral regimen in a child with vertically acquired multidrug-resistant HIV-1
    Alessandra Vigano
    Luigi Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 13:839-43. 2008
    ..The use of experimental agents might become a compelling issue in vertically HIV-infected children born in the era of highly active ART...
  27. pmc Spoligotyping and Mycobacterium tuberculosis
    Andrea Gori
    Institute of Infectious Diseases, L Sacco Hospital, University of Milan, Milan, Italy
    Emerg Infect Dis 11:1242-8. 2005
    ..The rapidity of this method in detection and typing could make it useful in the management of tuberculosis in a clinical setting...
  28. ncbi request reprint Sudden cardiac death in a young HIV-positive man on effective antiretroviral therapy
    Camilla Tincati
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Italy
    Curr HIV Res 6:560-2. 2008
    ..As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection...
  29. doi request reprint Rhodococcus equi infection in a patient with spinocellular carcinoma of unknown origin
    Elisa Borghi
    Department of Public Health Microbiology Virology, University of Milan, Milan, Italy
    J Med Microbiol 57:1431-3. 2008
    ..The patient, a knife-grinder, was promptly treated with levofloxacin plus amikacin followed by rifampicin for 2 months, and he is still in good clinical condition after an 8-month follow-up...
  30. pmc Microbial translocation in the pathogenesis of HIV infection and AIDS
    Giulia Marchetti
    Department of Health Sciences, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    Clin Microbiol Rev 26:2-18. 2013
    ..Given its detrimental effect on overall immunity, several interventions to prevent/block microbial translocation are currently under investigation as novel therapeutic agents for HIV/AIDS...
  31. ncbi request reprint Comparison between spoligotyping and IS6110 restriction fragment length polymorphisms in molecular genotyping analysis of Mycobacterium tuberculosis strains
    Andrea Gori
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, Milan 20157, Italy
    Mol Cell Probes 19:236-44. 2005
    ....
  32. pmc Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis
    Andrea Gori
    Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano Bicocca, Via Solferino 16 20052, Milan, Italy
    J Clin Microbiol 46:757-8. 2008
    ..This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis...
  33. doi request reprint Effective nocturnal oxygen therapy increases circulating level of tumor necrosis factor-alpha in heart failure
    Stefano Guzzetti
    Medicina I, Ospedale Luigi Sacco, Milano, Italy
    J Cardiovasc Med (Hagerstown) 9:64-7. 2008
    ..The aim of the present study was to evaluate whether standard O2 hospital therapy affects plasma concentration of TNF-alpha in stable CHF patients...
  34. doi request reprint Noncirrhotic portal hypertension in HIV-infected patients: a case control evaluation and review of the literature
    Miriam Cesari
    Section of Infectious Diseases and Immunopathology, Department of Clinical Sciences, Universita di Milano, L Sacco Hospital, Milan, Italy
    AIDS Patient Care STDS 24:697-703. 2010
    ....
  35. ncbi request reprint Delayed-type hypersensitivity skin testing can predict CD4 count increase in HIV patients with poor immunologic response to HAART
    Luca Meroni
    J Acquir Immune Defic Syndr 33:277-8. 2003
  36. doi request reprint Untangling the immunological implications of nadir on CD4+ cell recovery during suppressive highly active antiretroviral therapy
    Laurenzia Ferraris
    Clin Infect Dis 46:149-50. 2008