A Marchetti

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. pmc Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 78:73-8. 1998
  2. ncbi Int6 expression can predict survival in early-stage non-small cell lung cancer patients
    Fiamma Buttitta
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Clin Cancer Res 11:3198-204. 2005
  3. ncbi Assessing EGFR mutations
    Antonio Marchetti
    N Engl J Med 354:526-8; author reply 526-8. 2006
  4. ncbi Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features
    Fiamma Buttitta
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Int J Cancer 119:2586-91. 2006
  5. doi Recommendations for the analysis of ALK gene rearrangements in non-small-cell lung cancer: a consensus of the Italian Association of Medical Oncology and the Italian Society of Pathology and Cytopathology
    Antonio Marchetti
    Center of Predictive Molecular Medicine, Center of Excellence on Aging, University Foundation, Chieti, Italy
    J Thorac Oncol 8:352-8. 2013
  6. pmc Complex mutations & subpopulations of deletions at exon 19 of EGFR in NSCLC revealed by next generation sequencing: potential clinical implications
    Antonio Marchetti
    Center of Predictive Molecular Medicine, University Foundation, Chieti, Italy
    PLoS ONE 7:e42164. 2012
  7. ncbi EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    J Clin Oncol 23:857-65. 2005
  8. ncbi mRNA markers of breast cancer nodal metastases: comparison between mammaglobin and carcinoembryonic antigen in 248 patients
    A Marchetti
    Department of Oncology and Neurosciences, University Gabriele D Annunzio, 66100 Chieti, Italy
    J Pathol 195:186-90. 2001
  9. ncbi Reduced expression of INT-6/eIF3-p48 in human tumors
    A Marchetti
    Department of Oncology and Neurosciences, University Gabriele D Annunzio, Chieti, Italy
    Int J Oncol 18:175-9. 2001
  10. doi Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Hum Mutat 29:609-16. 2008

Collaborators

Detail Information

Publications33

  1. pmc Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 78:73-8. 1998
    ..002). Our data suggest that lung adenocarcinomas developed in subjects who had never smoked represent a distinct biological entity involving a co-alteration of the p53 gene and the FHIT locus in 20% of cases...
  2. ncbi Int6 expression can predict survival in early-stage non-small cell lung cancer patients
    Fiamma Buttitta
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Clin Cancer Res 11:3198-204. 2005
    ..This study aimed to investigate the prognostic role of Int6 in a large series of stage I non-small cell lung cancers (NSCLC) patients with long-term follow-up...
  3. ncbi Assessing EGFR mutations
    Antonio Marchetti
    N Engl J Med 354:526-8; author reply 526-8. 2006
  4. ncbi Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features
    Fiamma Buttitta
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Int J Cancer 119:2586-91. 2006
    ..3%) cases. EGFR, HER2 and K-ras mutations were found to be mutually exclusive events. The presence of HER2 mutations in a subset of patients with lung adenocarcinoma raise hope to treat these patients with HER2 specific kinase inhibitors...
  5. doi Recommendations for the analysis of ALK gene rearrangements in non-small-cell lung cancer: a consensus of the Italian Association of Medical Oncology and the Italian Society of Pathology and Cytopathology
    Antonio Marchetti
    Center of Predictive Molecular Medicine, Center of Excellence on Aging, University Foundation, Chieti, Italy
    J Thorac Oncol 8:352-8. 2013
    ..The European Medicines Agency accepted the regulatory submission of crizotinib for the treatment of these patients. Therefore, ALK gene testing has become mandatory to choose the most appropriate therapy...
  6. pmc Complex mutations & subpopulations of deletions at exon 19 of EGFR in NSCLC revealed by next generation sequencing: potential clinical implications
    Antonio Marchetti
    Center of Predictive Molecular Medicine, University Foundation, Chieti, Italy
    PLoS ONE 7:e42164. 2012
    ..In conclusion, NGS analysis of EGFR exon 19 in NSCLCs allowed us to formulate a new interpretative hypothesis for complex mutations and revealed the presence of subpopulations of deletions with potential pathogenetic and clinical impact...
  7. ncbi EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    J Clin Oncol 23:857-65. 2005
    ..Moreover, all lung adenocarcinomas were analyzed for K-ras mutations at codon 12 by allele-specific oligoprobe hybriditations...
  8. ncbi mRNA markers of breast cancer nodal metastases: comparison between mammaglobin and carcinoembryonic antigen in 248 patients
    A Marchetti
    Department of Oncology and Neurosciences, University Gabriele D Annunzio, 66100 Chieti, Italy
    J Pathol 195:186-90. 2001
    ..The detection sensitivity of the mammaglobin RT-PCR is far superior to that of the CEA RT-PCR, allowing the diagnosis of occult metastases in nearly one-third of cases...
  9. ncbi Reduced expression of INT-6/eIF3-p48 in human tumors
    A Marchetti
    Department of Oncology and Neurosciences, University Gabriele D Annunzio, Chieti, Italy
    Int J Oncol 18:175-9. 2001
    ..Additional studies on larger series of tumor specimens with long-term follow-up are needed to determine whether Int-6/eIF3-p48 expression may represent a new prognostic or predictive marker...
  10. doi Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Hum Mutat 29:609-16. 2008
    ..Such mutational events could represent an important step in the cancerogenesis of these tumors and may have potential implications for the selection of patients for targeted therapy...
  11. ncbi Telomerase activity as a prognostic indicator in stage I non-small cell lung cancer
    A Marchetti
    Department of Oncology and Neurosciences, University Gabriele D Annunzio, Chieti, Italy
    Clin Cancer Res 5:2077-81. 1999
    ..0173) and overall survival (P = 0.0187). Our data indicate that telomerase activity can be an important prognostic factor that should be considered in future prospective trials of adjuvant therapy for high-risk stage I NSCLC patients...
  12. ncbi Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome
    Antonio Marchetti
    Department of Oncology, University G D Annunzio, Chieti, Italy
    Clin Cancer Res 10:1338-43. 2004
    ..The aim of this study was to evaluate the prevalence and the clinical significance of HIN-1 mRNA expression in early stage non-small cell lung carcinomas (NSCLCs)...
  13. ncbi FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    J Pathol 184:240-6. 1998
    ..In conclusion, these results indicate that FHIT alterations are frequently involved in BAC tumourigenesis and that genetic changes in the p53 and K-ras genes can distinguish between different histotypes of BAC...
  14. pmc Evaluation of FHIT gene alterations in ovarian cancer
    F Buttitta
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 77:1048-51. 1998
    ..In none of these cases was the FHITgene found to be altered. Our results indicate that FHITplays a role in a small proportion of ovarian carcinomas...
  15. ncbi Cyclin D1 and retinoblastoma susceptibility gene alterations in non-small cell lung cancer
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    Int J Cancer 75:187-92. 1998
    ..Abnormalities of cyclin D1 and/or RB at the gene and/or expression level were present in more than 90% of cases, stressing that cyclin D1 and/or RB alterations represent an important step in lung tumorigenesis...
  16. ncbi Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract
    M A Caligo
    Department of Oncology, Division of Pathology, Labaratory of Molecular Genetics, University of Pisa, I 56126 Pisa, Italy
    Oncol Rep 7:1371-5. 2000
    ..Mutations in the repeated nucleotide stretches within the coding sequences of TGFbetaRII, IGFRII and bax genes were found only in colon tumors with a high unstable phenotype (more than 3 microsatellite loci altered)...
  17. ncbi Prediction of survival in stage I lung carcinoma patients by telomerase function evaluation
    Antonio Marchetti
    Department of Oncology and Neurosciences, University of Chieti, Chieti, Italy
    Lab Invest 82:729-36. 2002
    ..0053). Our results suggest that the two techniques used in this study evaluate separate aspects of telomerase function and their combination provides powerful prognostic information in lung cancer patients...
  18. ncbi Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human
    Francesco Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Arterioscler Thromb Vasc Biol 25:1925-31. 2005
    ....
  19. ncbi Human telomerase reverse transcriptase mRNA expression assessed by real-time reverse transcription polymerase chain reaction predicts chemosensitivity in patients with ovarian carcinoma
    Fiamma Buttitta
    Department of Oncology and Neurosciences, University of Chieti, Italy
    J Clin Oncol 21:1320-5. 2003
    ..To evaluate in vivo whether the expression of the human telomerase reverse transcriptase (hTERT) gene, the catalytic subunit of the telomerase complex, is predictive of response to chemotherapy in ovarian cancer patients...
  20. pmc Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: an important role for mutations in minor clones
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, 66013 Chiety, Italy
    Neoplasia 11:1084-92. 2009
    ..The use of sensitive detection methods could allow to more effectively identify treatment-resistant patients...
  21. doi High-risk human papilloma virus infection, tumor pathophenotypes, and BRCA1/2 and TP53 status in juvenile breast cancer
    Gitana Maria Aceto
    Unit of Molecular Pathology and Genomics, Aging Research Center CeSI G d Annunzio University Foundation, Via Colle dell Ara, 66100 Chieti, Italy
    Breast Cancer Res Treat 122:671-83. 2010
    ..Furthermore we implicate BRCA2 in a juvenile breast carcinoma diagnosed at 21 years of age, 4 years after an early full-term pregnancy, in absence of cancer family history...
  22. pmc Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells
    A Di Paolo
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 82:905-12. 2000
    ....
  23. ncbi Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients
    Antonio Marchetti
    Department of Oncology and Neurosciences, University G D Annunzio, Chieti, Italy 66100
    Cancer Res 62:2535-9. 2002
    ..We suggest that 90K expression could be a useful prognostic factor in patients with stage I non-small cell lung cancer, likely as an indicator of the metastatic propensity of the tumor...
  24. ncbi Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas
    Mattia Barbareschi
    Unit of Surgical Pathology, Laboratory of Molecular Pathology S Chiara Hospital, Trento, Italy, and Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Clin Cancer Res 13:6064-9. 2007
    ..We decided to investigate the association of PIK3CA mutations with pathologic features and clinical outcome in a large series of patients with breast cancer...
  25. ncbi PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma
    Fiamma Buttitta
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    J Pathol 208:350-5. 2006
    ....
  26. pmc Survival prediction of stage I lung adenocarcinomas by expression of 10 genes
    Fabrizio Bianchi
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    J Clin Invest 117:3436-44. 2007
    ..Thus, we have identified a predictive signature of limited size that can be analyzed by RT-PCR, a technology that is easy to implement in clinical laboratories...
  27. ncbi Jaagsiekte sheep retrovirus is not detected in human lung adenocarcinomas expressing antigens related to the Gag polyprotein of betaretroviruses
    Marcelo de las Heras
    Departmento de Patologia Animal, Facultad de Veterinaria, Universidad de Zaragoza, C Miguel Servet 177, 50013, Zaragoza, Spain
    Cancer Lett 258:22-30. 2007
    ....
  28. pmc Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers
    Masaharu Nomura
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Med 4:e125. 2007
    ..The objective of this study was to examine distributions of these three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers...
  29. ncbi Survivin gene expression in early-stage non-small cell lung cancer
    Monica Falleni
    Department of Medicine, Surgery and Dental Sciences, Division of Pathology, University of Milan, AO S Paolo, Via A Di Rudini 8, 20142 Milan, Italy
    J Pathol 200:620-6. 2003
    ..In addition, this study also documents that survivin overexpression could be exploited for diagnostic purposes and that quantitative real-time RT-PCR can be a useful tool for evaluating survivin activation in NSCLC...
  30. ncbi HER-2/Neu alterations in non-small cell lung cancer: a comprehensive evaluation by real time reverse transcription-PCR, fluorescence in situ hybridization, and immunohistochemistry
    Caterina Pellegrini
    Division of Pathology, Department of Medicine, Surgery and Dental Sciences, University of Milan, A O S Paolo and IRCCS Ospedale Maggiore, 20142 Milan, Italy
    Clin Cancer Res 9:3645-52. 2003
    ..The main purpose of our investigation includes the evaluation of the prevalence of HER2/neu alterations in non-small cell lung cancer (NSCLC) at different molecular levels...
  31. ncbi Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases
    Isabella Castellano
    Department of Biomedical Sciences and Human Oncology, University of Turin, 10126 Turin, Italy
    Oncol Rep 19:1271-5. 2008
    ..These data suggest that the HER2 FISH analysis may be an effective screening test in breast cancer metastases and G3 tumors, irrespective of the hormone receptor status or presence of lymphovascular invasion...
  32. ncbi Loss of beta4 integrin subunit reduces the tumorigenicity of MCF7 mammary cells and causes apoptosis upon hormone deprivation
    Giulia Bon
    Molecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy
    Clin Cancer Res 12:3280-7. 2006
    ..In this study, we investigated the biological consequences of interference with the endogenous beta4 integrin subunit expression...
  33. ncbi Quantitative evaluation of the apoptosis regulating genes Survivin, Bcl-2 and Bax in inflammatory and malignant pleural lesions
    Monica Falleni
    Department of Medicine Surgery and Dentistry, Division of Pathology, University of Milan, AO San Paolo e IRCCS Ospedale Maggiore, Via A Di Rudini 8, 20142 Milan, Italy
    Lung Cancer 48:211-6. 2005
    ..We aimed to identify defects in the programmed cell death pathway that can be related to pleural malignant mesothelioma (MM) unresponsiveness to chemotherapy...