G Marchesini

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. doi request reprint Under-treatment of migrants with diabetes in a universalistic health care system: The ARNO Observatory
    G Marchesini
    Unit of Metabolic Diseases and Clinical Dietetics, Alma Mater Studiorum University, Bologna, Italy Italian Diabetes Society, Rome, Italy Electronic address
    Nutr Metab Cardiovasc Dis 24:393-9. 2014
  2. pmc Clinical and psychological correlates of health-related quality of life in obese patients
    Edoardo Mannucci
    Department of Critical Care, University of Florence, Florence, Italy
    Health Qual Life Outcomes 8:90. 2010
  3. ncbi request reprint Snoring, hypertension and Type 2 diabetes in obesity. Protection by physical activity
    G Marchesini
    Dipartimento di Medicina Intema e Gastroenterologia, Alma Mater Studiorum University of Bologna, Italy
    J Endocrinol Invest 27:150-7. 2004
  4. doi request reprint The direct economic cost of pharmacologically-treated diabetes in Italy-2006. The ARNO observatory
    G Marchesini
    Unit of Metabolic Diseases and Clinical Dietetics, Alma Mater Studiorum University, Bologna, Italy
    Nutr Metab Cardiovasc Dis 21:339-46. 2011
  5. doi request reprint Obesity-associated liver disease
    Giulio Marchesini
    University of Bologna, Via Massarenti, 9, I 40138 Bologna, Italy
    J Clin Endocrinol Metab 93:S74-80. 2008
  6. ncbi request reprint Plasma ghrelin concentrations, food intake, and anorexia in liver failure
    Giulio Marchesini
    Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University of Bologna, I 40138 Bologna, Italy
    J Clin Endocrinol Metab 89:2136-41. 2004
  7. ncbi request reprint Metabolic syndrome and NASH
    Giulio Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University of Bologna, Policlinico S Orsola, Bologna, Italy
    Clin Liver Dis 11:105-17, ix. 2007
  8. doi request reprint Treatment of non-alcoholic fatty liver disease with focus on emerging drugs
    Giulio Marchesini
    University of Bologna, Unit of Metabolic Diseases and Clinical Dietetics, 9, Via Massarenti, I 40138 Bologna, Italy
    Expert Opin Emerg Drugs 16:121-36. 2011
  9. doi request reprint Managing the combination of nonalcoholic fatty liver disease and metabolic syndrome
    Simona Moscatiello
    University of Bologna, Alma Mater Studiorum, Unit of Metabolic Diseases and Clinical Dietetics, Policlinico S Orsola, Via Massarenti, 9, 40138 Bologna, Italy
    Expert Opin Pharmacother 12:2657-72. 2011
  10. ncbi request reprint Low ghrelin concentrations in nonalcoholic fatty liver disease are related to insulin resistance
    G Marchesini
    Unit of Metabolic Diseases, Alma Mater Studiorum, University of Bologna, I 40138 Bologna, Italy
    J Clin Endocrinol Metab 88:5674-9. 2003

Detail Information

Publications100

  1. doi request reprint Under-treatment of migrants with diabetes in a universalistic health care system: The ARNO Observatory
    G Marchesini
    Unit of Metabolic Diseases and Clinical Dietetics, Alma Mater Studiorum University, Bologna, Italy Italian Diabetes Society, Rome, Italy Electronic address
    Nutr Metab Cardiovasc Dis 24:393-9. 2014
    ..To assess whereas prevalence, treatment and direct costs of drug-treated diabetes were similar in migrants and in people of Italian citizenship under the universalistic Italian health care system...
  2. pmc Clinical and psychological correlates of health-related quality of life in obese patients
    Edoardo Mannucci
    Department of Critical Care, University of Florence, Florence, Italy
    Health Qual Life Outcomes 8:90. 2010
    ..We aimed to determine factors associated with poor HRQL in obese patients seeking weight loss in medical units, outside specific research projects...
  3. ncbi request reprint Snoring, hypertension and Type 2 diabetes in obesity. Protection by physical activity
    G Marchesini
    Dipartimento di Medicina Intema e Gastroenterologia, Alma Mater Studiorum University of Bologna, Italy
    J Endocrinol Invest 27:150-7. 2004
    ..These data underline the importance of lifestyle interventions to limit the burden of obesity and associated diseases...
  4. doi request reprint The direct economic cost of pharmacologically-treated diabetes in Italy-2006. The ARNO observatory
    G Marchesini
    Unit of Metabolic Diseases and Clinical Dietetics, Alma Mater Studiorum University, Bologna, Italy
    Nutr Metab Cardiovasc Dis 21:339-46. 2011
    ..To estimate the prevalence and the direct cost of pharmacologically-treated diabetes in Italy...
  5. doi request reprint Obesity-associated liver disease
    Giulio Marchesini
    University of Bologna, Via Massarenti, 9, I 40138 Bologna, Italy
    J Clin Endocrinol Metab 93:S74-80. 2008
    ..Accordingly, the worldwide epidemic of obesity is likely to become a relevant source of morbidity and mortality in the general population...
  6. ncbi request reprint Plasma ghrelin concentrations, food intake, and anorexia in liver failure
    Giulio Marchesini
    Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University of Bologna, I 40138 Bologna, Italy
    J Clin Endocrinol Metab 89:2136-41. 2004
    ..In the presence of anorexia, hyperghrelinemia might indicate a compensatory mechanism trying to stimulate food intake, which is nonetheless ineffective in the physiological range...
  7. ncbi request reprint Metabolic syndrome and NASH
    Giulio Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University of Bologna, Policlinico S Orsola, Bologna, Italy
    Clin Liver Dis 11:105-17, ix. 2007
    ..This evidence has precise therapeutic implications: only a behavioral approach to lifestyle correction will address all alterations characterizing the metabolic syndrome, including metabolic liver disease...
  8. doi request reprint Treatment of non-alcoholic fatty liver disease with focus on emerging drugs
    Giulio Marchesini
    University of Bologna, Unit of Metabolic Diseases and Clinical Dietetics, 9, Via Massarenti, I 40138 Bologna, Italy
    Expert Opin Emerg Drugs 16:121-36. 2011
    ..Non-alcoholic fatty liver disease (NAFLD) is becoming one of the most common causes of chronic liver disease worldwide. The economic and social cost of disease is very high and there is a need for effective treatments...
  9. doi request reprint Managing the combination of nonalcoholic fatty liver disease and metabolic syndrome
    Simona Moscatiello
    University of Bologna, Alma Mater Studiorum, Unit of Metabolic Diseases and Clinical Dietetics, Policlinico S Orsola, Via Massarenti, 9, 40138 Bologna, Italy
    Expert Opin Pharmacother 12:2657-72. 2011
    ..The prevalence of NAFLD is expected to rise, owing to the increasing worldwide prevalence of obesity and MetS; therefore, the identification of factors responsible for disease progression is essential to devise therapeutic strategies...
  10. ncbi request reprint Low ghrelin concentrations in nonalcoholic fatty liver disease are related to insulin resistance
    G Marchesini
    Unit of Metabolic Diseases, Alma Mater Studiorum, University of Bologna, I 40138 Bologna, Italy
    J Clin Endocrinol Metab 88:5674-9. 2003
    ..79; 95% confidence interval, 2.62-12.81; P < 0.0001) and specifically in NAFLD (2.96; 1.12-7.79; P = 0.028). The study suggests that insulin resistance is a major factor controlling ghrelin levels in subjects with and without NAFLD...
  11. ncbi request reprint Branched-chain amino acid supplementation in patients with liver diseases
    Giulio Marchesini
    Department of Internal Medicine, Alma Mater Studiorum, University of Bologna, Italy
    J Nutr 135:1596S-601S. 2005
    ..The number of patients who cannot tolerate dietary proteins in amounts sufficient to meet the higher catabolism of advanced liver disease is probably low, but BCAAs remain the sole treatment of proved efficacy in this specific setting...
  12. ncbi request reprint Is liver disease a threat to patients with metabolic disorders?
    Giulio Marchesini
    Unit of Metabolic Diseases, Alma Mater Studiorum University, Bologna, and San Giovanni Battista Hospital, Turin, Italy
    Ann Med 37:333-46. 2005
    ....
  13. ncbi request reprint Review article: the treatment of fatty liver disease associated with the metabolic syndrome
    G Marchesini
    Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 22:37-9. 2005
    ..Several uncontrolled and controlled studies have documented an improvement in liver biochemistry and in histology, but the long-term results remain unsettled. This is an area where significant advances are expected in the next few years...
  14. ncbi request reprint Aminotransferase and gamma-glutamyltranspeptidase levels in obesity are associated with insulin resistance and the metabolic syndrome
    G Marchesini
    Metabolic Unit, Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Endocrinol Invest 28:333-9. 2005
    ..We conclude that in obesity insulin resistance is a risk factor for raised liver enzyme levels, possibly related to NAFLD...
  15. ncbi request reprint Hepatotoxicity of fast food?
    Giulio Marchesini
    Clinical Dietetics, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, 9, Via Massarenti, I 40138 Bologna, Italy
    Gut 57:568-70. 2008
  16. ncbi request reprint Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
    ..NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistance...
  17. doi request reprint Are behavioural approaches feasible and effective in the treatment of type 2 diabetes? A propensity score analysis vs. prescriptive diet
    G Forlani
    Unit of Metabolic Diseases, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Nutr Metab Cardiovasc Dis 19:313-20. 2009
    ..We report a prospective cohort study, carried out in 822 consecutive subjects with type 2 diabetes, first seen in a 4-year period in a diabetes unit of an academy hospital...
  18. ncbi request reprint Psychiatric distress and health-related quality of life in obesity
    G Marchesini
    Metabolic Unit, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Diabetes Nutr Metab 16:145-54. 2003
    ..In a large proportion of patients psychopathological distress is also present and its role on poor HRQL has never been quantified...
  19. ncbi request reprint Weight cycling in treatment-seeking obese persons: data from the QUOVADIS study
    G Marchesini
    Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Int J Obes Relat Metab Disord 28:1456-62. 2004
    ..To determine parameters of weight history useful for the assessment of weight cycling and their association with psychological distress and binge eating...
  20. ncbi request reprint Metabolic syndrome, psychological status and quality of life in obesity: the QUOVADIS Study
    F Corica
    Department of Internal Medicine, University of Messina, Messina, Italy
    Int J Obes (Lond) 32:185-91. 2008
    ..In particular, our aim was to investigate the relative impact of physical symptoms, somatic diseases and psychological distress on both the physical and the mental domains of HRQL...
  21. ncbi request reprint Eating behavior affects quality of life in type 2 diabetes mellitus
    F Cerrelli
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
    Eat Weight Disord 10:251-7. 2005
    ..A disordered eating behavior may be present in T2DM patients, and is associated with poor HRQL. This condition must be considered for an olistic approach to weight control...
  22. ncbi request reprint Psychological status and depression in patients with liver cirrhosis
    G Bianchi
    Department of Internal Medicine, Cardioangiology, Hepatology, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Dig Liver Dis 37:593-600. 2005
    ..Previous studies reported an impairment of both the physical and mental dimensions of quality of life in patients with cirrhosis. Very few data are available on the psychological impact of the disease and its relation to liver function...
  23. ncbi request reprint Effects of hyperglycaemia and hyperinsulinaemia on plasma amino acid levels in obese subjects with normal glucose tolerance
    G Marchesini
    Department of Internal Medicine and Gastroenterology, Unit of Metabolic Diseases, University of Bologna, Bologna, Italy
    Int J Obes Relat Metab Disord 24:552-8. 2000
    ..To investigate the effects of hyperglycaemia and hyperinsulinaemia on amino acid disposal in human obesity...
  24. ncbi request reprint Prevalence of elevated liver enzymes in Type 2 diabetes mellitus and its association with the metabolic syndrome
    G Forlani
    Unit of Metabolic Diseases and Clinical Dietetics, Alma Mater Studiorum University, Bologna, Italy
    J Endocrinol Invest 31:146-52. 2008
    ..A large amount of diabetes patients may require a thorough clinical, laboratory and histological investigation...
  25. ncbi request reprint WHO and ATPIII proposals for the definition of the metabolic syndrome in patients with Type 2 diabetes
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Diabet Med 21:383-7. 2004
    ..Its identification is of particular importance for coronary risk assessment...
  26. doi request reprint A controlled, class-based multicomponent intervention to promote healthy lifestyle and to reduce the burden of childhood obesity
    E Centis
    Unit of Metabolic Diseases and Clinical Dietetics, Alma Mater Studiorum University, Bologna, Italy
    Pediatr Obes 7:436-45. 2012
    ..Overweight and obesity prevention in childhood and adolescence represent a priority for public health; school is a privileged place for health promotion interventions...
  27. doi request reprint Venesection for non-alcoholic fatty liver disease unresponsive to lifestyle counselling--a propensity score-adjusted observational study
    L Valenti
    Department of Internal Medicine, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    QJM 104:141-9. 2011
    ....
  28. ncbi request reprint A physical activity program to reinforce weight maintenance following a behavior program in overweight/obese subjects
    N Villanova
    Department Internal Medicine and Gastroenterology, Unit of Metabolic Diseases, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Int J Obes (Lond) 30:697-703. 2006
    ..To investigate the effects of a specific program to implement physical activity (fitness program) on weight loss maintenance, activity level and resting energy expenditure (REE)...
  29. ncbi request reprint Splanchnic haemodynamics in non-alcoholic fatty liver disease: effect of a dietary/pharmacological treatment. A pilot study
    D Magalotti
    Department of Internal Medicine, Cardioangiology and Hepatology, Policlinico S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Dig Liver Dis 36:406-11. 2004
    ..Previous studies demonstrated that in experimental animals fatty liver is associated with reduced hepatic blood flow and that metformin reverses steatosis, while no data were reported in humans...
  30. ncbi request reprint Impaired insulin-mediated amino acid plasma disappearance in non-alcoholic fatty liver disease: a feature of insulin resistance
    G Bianchi
    Department of Internal Medicine, Cardioangiology, Hepatology, Universita di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    Dig Liver Dis 35:722-7. 2003
    ..It is usually measured on glucose metabolism; the effects on amino acid regulation have never been assessed. In particular, no data are available on insulin-dependent branched-chain amino acid metabolism, which is under insulin control...
  31. ncbi request reprint Which treatment for nonalcoholic fatty liver disease?
    S Moscatiello
    Unit of Clinical Dietetics, Alma Mater Studiorum University of Bologna, Policlinico S Orsola, Via Massarenti, 9, I 40138 Bologna, Italy
    Mini Rev Med Chem 8:767-75. 2008
    ..Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes...
  32. doi request reprint Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
    Anna Ludovica Fracanzani
    Department of Internal Medicine, Scientific Institute of Recovery and Cure Foundation IRCCS, Hospital Maggiore Policlinico, University of Milan, Milan, Italy
    Hepatology 48:792-8. 2008
    ..07; 95% CI, 1.02-1.14), and diabetes (OR, 1.8; 95% CI, 1.4-2.3) in the overall series, serum ferritin and diabetes in those with increased ALT, and only HOMA-IR (OR, 1.97; 95% CI, 1.2-3.7) in patients with normal ALT...
  33. ncbi request reprint WHO and ADA criteria for the diagnosis of diabetes mellitus in relation to body mass index. Insulin sensitivity and secretion in resulting subcategories of glucose tolerance
    N Melchionda
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Bologna, Italy
    Int J Obes Relat Metab Disord 26:90-6. 2002
    ....
  34. ncbi request reprint Factors associated with poor health-related quality of life of patients with cirrhosis
    G Marchesini
    Universita di Bologna, Bologna, Italy
    Gastroenterology 120:170-8. 2001
    ..In cirrhosis, both physical functioning and mental well-being may be altered, but no study has investigated factors associated with a poor perceived health status...
  35. ncbi request reprint Reduced quality of life in patients with chronic hepatitis C: effects of interferon treatment
    G Bianchi
    Department of Internal Medicine, University of Bologna, Italy
    Dig Liver Dis 32:398-405. 2000
    ..Quality of life is an area of increasing interest in hepatology. Studies, so far, have assessed quality of life in patients with chronic virus C-related hepatitis in relation to antiviral therapy by means of generic questionnaires...
  36. ncbi request reprint Effects of cognitive-behavioural therapy on health-related quality of life in obese subjects with and without binge eating disorder
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Int J Obes Relat Metab Disord 26:1261-7. 2002
    ..To measure the effects of cognitive-behavioural therapy on health-related quality of life (HRQL) in obese patients, in relation to binge eating disorder...
  37. ncbi request reprint Non-alcoholic fatty liver and insulin resistance: a cause-effect relationship?
    E Bugianesi
    Gastroenterology Department, University of Turin, Turin, Italy
    Dig Liver Dis 36:165-73. 2004
    ..Future trials need to be performed in order to test the long-term effectiveness of these treatments on the basis of clinically relevant histological outcomes...
  38. ncbi request reprint An empowerment-based educational program improves psychological well-being and health-related quality of life in Type 1 diabetes
    G Forlani
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum University, Bologna, Italy
    J Endocrinol Invest 29:405-12. 2006
    ..Repeated educational interventions are the way towards a normal life with Type 1 DM...
  39. ncbi request reprint The QUOVADIS Study: features of obese Italian patients seeking treatment at specialist centers
    N Melchionda
    University of Bologna, Italy
    Diabetes Nutr Metab 16:115-24. 2003
    ....
  40. ncbi request reprint Diabetes and liver disease: an ominous association
    Simona Moscatiello
    Unit of Metabolic Diseases, Alma Mater Studiorum University, Policlinico S Orsola, Via Massarenti 9, I 40138 Bologna, Italy
    Nutr Metab Cardiovasc Dis 17:63-70. 2007
    ....
  41. ncbi request reprint Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver
    Elisabetta Bugianesi
    Division of Gastro Hepatology, Department of Internal Medicine, University of Turin, Turin, Italy
    Hepatology 39:179-87. 2004
    ..Increased ferritin levels are markers of severe histologic damage, but not of iron overload. Iron burden and HFE mutations do not contribute significantly to hepatic fibrosis in the majority of patients with NAFLD...
  42. doi request reprint Metabolic syndrome and insulin resistance in subjects with morbid obesity
    Valentina Soverini
    Clinical Dietetics, Alma Mater Studiorum University, S Orsola Malpighi Hospital, Bologna, Italy
    Obes Surg 20:295-301. 2010
    ..We aimed to assess the prevalence of the metabolic syndrome (MS) in nondiabetic subjects with morbid obesity (body mass index (BMI) > or = 40 kg/m2) and its correlation with insulin resistance...
  43. doi request reprint HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease
    Luca Valenti
    Department of Internal Medicine, Universita degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Gastroenterology 138:905-12. 2010
    ..We investigated whether these factors also contribute to the progression of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD)...
  44. ncbi request reprint Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    Elisabetta Bugianesi
    Department of Gastroenterology, Ospedale S Giovanni Battista, University of Turin, Turin, Italy
    Gastroenterology 123:134-40. 2002
    ..Nonalcoholic steatohepatitis (NASH) may progress to cirrhosis; whether NASH plays also a role in the development of hepatocellular carcinoma (HCC) is unknown...
  45. ncbi request reprint Oxidative stress and anti-oxidant metabolites in patients with hyperthyroidism: effect of treatment
    G Bianchi
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Universita di Bologna, Policlinico S Orsola, Italy
    Horm Metab Res 31:620-4. 1999
    ..Experimental studies showed an elevated oxidative stress during hyperthyroidism, which is reduced by treatment. Therapy per se might decrease oxidative stress...
  46. ncbi request reprint Liver inflammatory cells, apoptosis, regeneration and stellate cell activation in non-alcoholic steatohepatitis
    M Susca
    Dept. Internal Medicine, University of Bologna, S. Orsola Hospital, Italy
    Dig Liver Dis 33:768-77. 2001
    ..This makes liver biopsy an essential part of the clinical setting supporting diagnosis, evaluation of severity and possibly definition of the evolutionary trend...
  47. ncbi request reprint Hepatic steatosis in obese patients: clinical aspects and prognostic significance
    D Festi
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Obes Rev 5:27-42. 2004
    ..Modifications in lifestyle (e.g. diet and exercise) to reduce obesity remain the mainstay of prevention and treatment of a disease, which puts a large number of individuals at risk of advanced liver disease in the near future...
  48. ncbi request reprint Health-related quality of life in obesity: the role of eating behaviour
    G Marchesini
    Servizio di Malattie del Metabolismo, Universita di Bologna, Azienda Ospedaliera S Orsola Malpighi, Italy
    Diabetes Nutr Metab 13:156-64. 2000
    ..Treatment of binge eating may be as important as any weight-reducing intervention for the overall well-being of the majority of obese persons...
  49. ncbi request reprint Health-related quality of life in patients with thyroid disorders
    G P Bianchi
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Universita di Bologna, Italy
    Qual Life Res 13:45-54. 2004
    ..HRQL was significantly reduced in patients with thyroid diseases referred to a secondary level endocrinology unit. Perceived health status may be considered as an additional outcome of management and therapy of thyroid disorders...
  50. ncbi request reprint The burden of obesity on everyday life: a role for osteoarticular and respiratory diseases
    G Marchesini
    Servizio di Malattie del Metabolismo, Alma Mater Studiorum Universita di Bologna, Azienda Ospedaliera S Orsola Malpighi, Via Massarenti 9, 1 40138 Bologna, Italy
    Diabetes Nutr Metab 16:284-90. 2003
    ..Osteoarticular and respiratory diseases are major determinants of poor HRQL in obesity. Prevention strategies and treatment of somatic diseases are mandatory for a comprehensive approach to obesity...
  51. ncbi request reprint Non-alcoholic steatohepatitis in patients cared in metabolic units
    Giulio Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Alma Mater Studiorum, Via Massarenti 9, Policlinico S Orsola, I 40138 Bologna, Italy
    Diabetes Res Clin Pract 63:143-51. 2004
    ..Liver biopsy is recommended for diagnostic and prognostic purposes, as well as for testing treatment effects in controlled trials...
  52. doi request reprint Metabolic syndrome in liver transplantation: relation to etiology and immunosuppression
    Giampaolo Bianchi
    Dipartimento di Medicina Interna and Centro Trapianti di Fegato e Multiorgano, Alma Mater Studiorum, Universita di Bologna, Bologna, Italy
    Liver Transpl 14:1648-54. 2008
    ..Disorders related to MS are frequent in LTx patients, and are related to both pre-LTx conditions and to weight gain. Weight control is mandatory in LTx patients to prevent risk factors of premature atherosclerosis...
  53. ncbi request reprint Nonalcoholic fatty liver disease and the metabolic syndrome
    Giulio Marchesini
    Unit of Metabolic Diseases, Alma Mater Studiorum University of Bologna, Italy
    Curr Opin Lipidol 16:421-7. 2005
    ..Insulin resistance is the common factor connecting obesity, diabetes, hypertension and dyslipidemia with fatty liver and the progression of hepatic disease to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma...
  54. ncbi request reprint Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial
    Giulio Marchesini
    Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Gastroenterology 124:1792-801. 2003
    ..The role of oral supplementation with branched-chain amino acids (BCAA) in advanced cirrhosis is far from settled. A nutritional approach might prevent progressive liver failure and improve nutritional parameters and quality of life...
  55. ncbi request reprint Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    Giulio Marchesini
    Unit of Metabolic Diseases and Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Hepatology 37:917-23. 2003
    ..The increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades...
  56. doi request reprint Adiponectin isoforms, insulin resistance and liver histology in nonalcoholic fatty liver disease
    Giampaolo Bianchi
    Department of Internal Medicine, Alma Mater Studiorum University, Bologna, Italy
    Dig Liver Dis 43:73-7. 2011
    ..Nonalcoholic fatty liver disease is associated with insulin resistance and low adiponectin levels. Adiponectin circulates as high-, medium- and low-molecular weight complexes, possibly exerting different insulin-sensitising effects...
  57. ncbi request reprint Homocysteine and psychological traits: a study in obesity
    Giulio Marchesini
    Department of Internal Medicine and Gastroenterology, Unit of Metabolic Diseases, University of Bologna, Bologna, Italy
    Nutrition 18:403-7. 2002
    ..Further, homocysteine might be the link between psychological traits (namely anger and hostility) and cardiovascular disease, mediated by stressful events and sympathetic nervous tone...
  58. ncbi request reprint Effects of long-term oral misoprostol administration on hepatic amino acid-nitrogen metabolism in patients with cirrhosis
    Giampaolo Bianchi
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Alma Mater Studiorum, Universita di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    J Hepatol 37:15-21. 2002
    ..The acute infusion of a Prostaglandin of E series 1 (PGE1) analogue results in nitrogen sparing in cirrhosis...
  59. ncbi request reprint Reduced quality of life of patients with hepatocellular carcinoma
    G Bianchi
    Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Policlinico S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Dig Liver Dis 35:46-54. 2003
    ..It has been shown that health-related quality of life is reduced in patients with cirrhosis and with chronic hepatitis in relation to antiviral therapy. No data are available on patients with hepatocellular carcinoma...
  60. ncbi request reprint Update on nutritional supplementation with branched-chain amino acids
    Giampaolo Bianchi
    Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Curr Opin Clin Nutr Metab Care 8:83-7. 2005
    ..In addition, the competitive action of BCAAs on amino acid transport across the blood-brain barrier may ultimately alter the synthesis of brain neurotransmitters, involved in neurological diseases...
  61. ncbi request reprint Nonalcoholic fatty liver disease and the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Minerva Cardioangiol 54:229-39. 2006
    ..Prevention and intervention programs based on lifestyle are therefore mandatory to reduce the burden of metabolic liver disease...
  62. ncbi request reprint Role of nutrition in gastrointestinal oncological patients
    R Di Luzio
    Clinical Dietetics, Alma Mater Studiorum University, Bologna, Italy
    Eur Rev Med Pharmacol Sci 14:277-84. 2010
    ....
  63. ncbi request reprint Insulin resistance: a metabolic pathway to chronic liver disease
    Elisabetta Bugianesi
    Gastroenterology Department, University of Turin, Turin, Italy
    Hepatology 42:987-1000. 2005
    ..Finally, the ability of insulin-sensitizing, pharmacological agents to treat NAFLD by reducing IR in the liver (metformin) and in the periphery (thiazolidinediones) are discussed...
  64. doi request reprint Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C
    Ester Vanni
    Division of Gastro Hepatology, San Giovanni Battista Hospital, University of Turin, Turin, Italy
    Hepatology 50:697-706. 2009
    ..Substrate competition by increased lipid oxidation and possibly enhanced hepatic expression of inflammatory cytokines/mediators could be involved in the defective glucose regulation...
  65. ncbi request reprint The effect of obesity management on body image in patients seeking treatment at medical centers
    Riccardo Dalle Grave
    Unit of Metabolic Diseases, Alma Mater University of Bologna, Policlinico S Orsola, Via Massarenti, 9, I 40138 Bologna, Italy
    Obesity (Silver Spring) 15:2320-7. 2007
    ..Body image dissatisfaction is common in treatment-seeking patients with obesity. We aimed to investigate the effects of obesity management on body image in patients with obesity attending Italian medical centers for weight loss programs...
  66. ncbi request reprint Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study
    Luca Valenti
    Department of Internal Medicine, Universita di Milano, Ospedale Policlinico Mangiagalli Regina Elena IRCCS, Milano, Italy
    Am J Gastroenterol 102:1251-8. 2007
    ..Aims of this study were to define the relationship between ferritin and iron stores in patients with NAFLD, the effect of iron depletion on insulin resistance, and whether basal ferritin levels influence treatment outcome...
  67. ncbi request reprint Insulin glargine improves glycemic control and health-related quality of life in type 1 diabetes
    Rita Manini
    Unit of Metabolic Disease, Alma Mater Studiorum University of Bologna, S Orsola Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Nutr Metab Cardiovasc Dis 17:493-8. 2007
    ..To date, only one study has measured the effects of glargine on health-related quality of life (HRQL); the aim of this study was therefore to confirm the beneficial effects of glargine on disease-specific HRQL in type 1 diabetes...
  68. ncbi request reprint Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease
    Nicola Villanova
    Unit of Metabolic Diseases, Alma Mater Studiorum University of Bologna, Policlinico S Orsola Malpighi, Via Massarenti 9, I 40138 Bologna, Italy
    Hepatology 42:473-80. 2005
    ..The risk of advanced liver disease is well recognized in NAFLD patients, but the large majority of cases might experience cardiovascular disease in the long term, indirectly limiting the burden of liver failure...
  69. pmc Body composition changes after transjugular intrahepatic portosystemic shunt in patients with cirrhosis
    Jonathan Montomoli
    Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna S Orsola Malpighi Hospital, Via Albertoni 15, I 40138 Bologna, Italy
    World J Gastroenterol 16:348-53. 2010
    ..To investigate the effect of transjugular intrahepatic porto-systemic shunt (TIPS) on malnutrition in portal hypertensive cirrhotic patients...
  70. ncbi request reprint Update on branched-chain amino acid supplementation in liver diseases
    Giampaolo Bianchi
    Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Italy
    Curr Opin Gastroenterol 21:197-200. 2005
    ..In addition, the competitive action of BCAAs on amino acid transport across the blood-brain barrier may improve hepatic encephalopathy...
  71. ncbi request reprint Construct validity of the Short Form-36 Health Survey and its relationship with BMI in obese outpatients
    Francesco Corica
    Department of Internal Medicine, University of Messina, Messina, Italy
    Obesity (Silver Spring) 14:1429-37. 2006
    ..To investigate the construct validity of the Short Form-36 (SF-36) Health Survey questionnaire in obese patients...
  72. doi request reprint The effect of lifestyle changes in non-alcoholic fatty liver disease
    Elena Centis
    Clinical Dietetics, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Dig Dis 28:267-73. 2010
    ..Only a synergistic approach and a global societal response might be effective in reducing the burden of advanced liver disease and premature death due to NAFLD/NASH (non-alcoholic steatohepatitis)...
  73. pmc Adherence to chronic cardiovascular therapies: persistence over the years and dose coverage
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 63:346-55. 2007
    ..To evaluate adherence to chronic cardiovascular drug treatments, in terms of long-term persistence and dose coverage...
  74. ncbi request reprint Gender, fatty liver and GGT
    Lucia Carulli
    Hepatology 44:278-9. 2006
  75. ncbi request reprint Psychological distress in morbid obesity in relation to weight history
    Maria Letizia Petroni
    Nutrition Rehabilitation Unit, IRCCS Istituto Auxologico Italiano, Piancavallo Verbania, Italy
    Obes Surg 17:391-9. 2007
    ..In subjects with childhood obesity, psychological distress might be better than in adult-onset obesity, because of progressive adaptation to the social stigma...
  76. ncbi request reprint Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity
    Elisabetta Bugianesi
    Division of Gastroenterology, University of Turin, Ospedale San Giovanni Battista, Corso Bramante 88, I 10126 Torino, Italy
    J Clin Endocrinol Metab 90:3498-504. 2005
    ..Hypoadiponectinemia in NAFLD is part of a metabolic disturbance characterized by ectopic fat accumulation in the central compartment...
  77. ncbi request reprint Weight loss expectations in obese patients seeking treatment at medical centers
    Riccardo Dalle Grave
    Department of Nutritional Rehabilitation, Villa Garda Hospital, Garda, Italy
    Obes Res 12:2005-12. 2004
    ....
  78. ncbi request reprint Weight loss expectations in obese patients and treatment attrition: an observational multicenter study
    Riccardo Dalle Grave
    Villa Garda Hospital, Garda, Verona, Italy
    Obes Res 13:1961-9. 2005
    ..To investigate the influence of weight loss expectations (expected 1-year BMI loss, dream and maximum acceptable BMI) on attrition in obese patients seeking treatment...
  79. ncbi request reprint Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): treatment
    Elisabetta Bugianesi
    Department of Gastroenterology, San Giovanni Battista Hospital, University of Turin, Corso Bramante 88, I 10127 Turin, Italy
    Best Pract Res Clin Gastroenterol 18:1105-16. 2004
    ..Large, long-term, placebo-controlled randomized studies are eagerly awaited. Outside controlled studies, nutritional counselling and physical exercise aimed at moderate weight loss remain the basis of any therapeutic intervention...
  80. ncbi request reprint Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    Giorgio Bedogni
    Centro Studi Fegato, Area Science Park, Basovizza, and Department of BBCM, University of Trieste, Italy
    Hepatology 42:44-52. 2005
    ..In conclusion, NAFLD is highly prevalent in the general population, is not associated with SLD, but is associated with many features of the metabolic syndrome...
  81. ncbi request reprint Correspondence between the International Diabetes Federation criteria for metabolic syndrome and insulin resistance in a cohort of Italian nondiabetic Caucasians: the GISIR database
    Giorgio Sesti
    Diabetes Care 30:e33. 2007
  82. ncbi request reprint Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
    Diabetes Care 30:2638-40. 2007
  83. ncbi request reprint NASH: from liver diseases to metabolic disorders and back to clinical hepatology
    Giulio Marchesini
    Hepatology 35:497-9. 2002
  84. ncbi request reprint The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:846-54. 2007
    ..By applying this model, a liver biopsy would have been avoided in 549 (75%) of the 733 patients, with correct prediction in 496 (90%)...
  85. ncbi request reprint The metabolic syndrome in treatment-seeking obese persons
    Giulio Marchesini
    Department of Diabetes and Endocrinology, Birmingham Heartlands Hospital, Birmingham, UK
    Metabolism 53:435-40. 2004
    ..It is time to move towards a more integrated approach and to reconsider resource allocation to improve lifestyle changes for large-scale control of obesity...
  86. doi request reprint Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Am J Gastroenterol 103:1136-44. 2008
    ..We aimed to assess whether increasing degrees of IR, up to overt diabetes, are linked to steatosis and higher stages of fibrosis in patients with CHC resulting from genotype 1 HCV (G1-HCV)...
  87. ncbi request reprint Behavior therapy for nonalcoholic fatty liver disease: The need for a multidisciplinary approach
    Stefano Bellentani
    Liver and Nutrition Center, Ramazzini Hospital, Carpi, Modena, Italy
    Hepatology 47:746-54. 2008
    ..Alternatively, general practitioners and physicians working in gastrointestinal units should limit their intervention to engage patients with NAFLD before referral to specialized teams set up for the treatment of diabetes and obesity...
  88. doi request reprint Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Hepatology 48:28-37. 2008
    ..045; 95% confidence interval, 1.020 to 1.070; P = 0.0004), whereas waist circumference was associated with moderate-severe steatosis in NAFLD (odds ratio, 1.095; 95% confidence interval, 1.007 to 1.192; P = 0.03)...
  89. doi request reprint Compulsive exercise to control shape or weight in eating disorders: prevalence, associated features, and treatment outcome
    Riccardo Dalle Grave
    Department of Eating Disorder and Obesity, Villa Garda Hospital, 37016 Garda Vr, Italy
    Compr Psychiatry 49:346-52. 2008
    ..The study was aimed at assessing the prevalence of compulsive exercising to control shape and weight in eating disorders (EDs) and its relationship with treatment outcome...
  90. ncbi request reprint NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes
    Elisabetta Bugianesi
    Division of Gastro Hepatology, University of Turin, S Giovanni Battista Hospital, Corso Bramante 88, Turin 10126, Italy
    Curr Diab Rep 7:175-80. 2007
    ..Although cardiovascular risk remains the major cause for excess mortality in type 2 diabetes mellitus, the risk of progressive liver disease should no longer be underscored...
  91. ncbi request reprint A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    Elisabetta Bugianesi
    Department of Gastroenterology, University of Turin, Italy
    Am J Gastroenterol 100:1082-90. 2005
    ..We aimed to compare the usefulness of metformin versus prescriptive diet or vitamin E...
  92. doi request reprint Personality dimensions and treatment drop-outs among eating disorder patients treated with cognitive behavior therapy
    Riccardo Dalle Grave
    Department of Eating and Weight Disorder, Villa Garda Hospital, Via Montebaldo, 89, 37016 Garda Vr, Italy
    Psychiatry Res 158:381-8. 2008
    ..Eating disorder patients with low Persistence scores are significantly less likely to complete inpatient treatment...
  93. ncbi request reprint A positive blood alcohol concentration is the main predictor of recurrent motor vehicle crash
    Andrea Fabbri
    Dipartimento di Urgenza Accettazione, Azienda Unità Sanitaria Locale di Forlì, Forli, Italy
    Ann Emerg Med 46:161-7. 2005
    ..Our objective is to determine the main variables predicting recurrent crashes in subjects attending an emergency department (ED) for injuries after motor vehicle crash...
  94. ncbi request reprint Diabetes prevention strategy in offspring of type 2 diabetic patients with a direct involvement of the diseased parents
    Katia Bonomo
    Nutr Metab Cardiovasc Dis 15:237-8. 2005
  95. ncbi request reprint NAFLD treatment: cognitive-behavioral therapy has entered the arena
    Giulio Marchesini
    J Hepatol 43:926-8. 2005
  96. ncbi request reprint Non-alcoholic fatty liver disease (NAFLD)--a novel common aspect of the metabolic syndrome
    Katerina Bogdanova
    Department of Pathological Physiology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:101-4. 2006
    ..There is urgent need in terms of both intensive research pursuits and effective practical measures to deal with this common threat...
  97. ncbi request reprint Metabolic syndrome and health-related quality of life: does psychological well-being matter?
    Andrea Corsonello
    Ann Epidemiol 18:592-3. 2008
  98. ncbi request reprint The effect of inpatient cognitive-behavioral therapy for eating disorders on temperament and character
    Riccardo Dalle Grave
    Department of Eating and Weight Disorder, Villa Garda Hospital, Garda, Verona, Italy
    Behav Res Ther 45:1335-44. 2007
    ..These results are relevant for future studies based on TCI...
  99. ncbi request reprint Monitoring intervention programmes for out-of-hospital cardiac arrest in a mixed urban and rural setting
    Andrea Fabbri
    Dipartimento dell Emergenza, Azienda USL Forlì, Italy
    Resuscitation 71:180-7. 2006
    ....
  100. ncbi request reprint Type 2 diabetes and the Naaman syndrome
    Giulio Marchesini
    Diabetes Care 26:3195. 2003