D Marazziti

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint Distribution of [3H]GR65630 binding in human brain postmortem
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Clinica Psichiatrica, University of Pisa, Italy
    Neurochem Res 26:187-90. 2001
  2. ncbi request reprint Insight in obsessive-compulsive disorder: a study of an Italian sample
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    Eur Psychiatry 17:407-10. 2002
  3. ncbi request reprint The neurobiology of attraction
    D Marazziti
    Department of Psychiatry, Neurobiology, Pharmachology and Biotechnologies, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:58-60. 2003
  4. ncbi request reprint Binding of 3H-WIN-35,428 and 125I-RTI-121 to human platelet membranes
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Neurochem Res 31:361-5. 2006
  5. doi request reprint Pharmacokinetics and pharmacodynamics of psychotropic drugs: effect of sex
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, University of Pisa, Pisa, Italy
    CNS Spectr 18:118-27. 2013
  6. ncbi request reprint The relationship between epilepsy and depression: an update
    M Catena-Dell'Osso
    Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Curr Med Chem 20:2861-7. 2013
  7. ncbi request reprint The role of platelet/lymphocyte serotonin transporter in depression and beyond
    Donatella Marazziti
    Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Via Roma 67, Pisa, Italy
    Curr Drug Targets 14:522-30. 2013
  8. ncbi request reprint Prefrontal cortex, dopamine, and jealousy endophenotype
    Donatella Marazziti
    Department of Psychiatry, University of Pisa, Pisa, Italy
    CNS Spectr 18:6-14. 2013
  9. pmc The neurobiology of moral sense: facts or hypotheses?
    Donatella Marazziti
    Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Via Roma 67, Pisa, 56100, Italy
    Ann Gen Psychiatry 12:6. 2013
  10. ncbi request reprint Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Curr Med Chem 20:371-7. 2013

Detail Information

Publications98

  1. ncbi request reprint Distribution of [3H]GR65630 binding in human brain postmortem
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Clinica Psichiatrica, University of Pisa, Italy
    Neurochem Res 26:187-90. 2001
    ..These observations extend previous findings on the distribution of 5-HT3 receptors and confirm interspecies variations that might explain the heterogeneous properties of 5-HT3 receptors in different animals...
  2. ncbi request reprint Insight in obsessive-compulsive disorder: a study of an Italian sample
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    Eur Psychiatry 17:407-10. 2002
    ..Further studies seem to be necessary in order to establish whether or not OCD patients with poor insight represent a distinct sub-group of patients...
  3. ncbi request reprint The neurobiology of attraction
    D Marazziti
    Department of Psychiatry, Neurobiology, Pharmachology and Biotechnologies, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:58-60. 2003
    ..This paper will make some general speculations on the attraction process, in the light of the experience of the Authors...
  4. ncbi request reprint Binding of 3H-WIN-35,428 and 125I-RTI-121 to human platelet membranes
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Neurochem Res 31:361-5. 2006
    ..In conclusions, therefore, platelets would not seem to be a useful model for exploring the DAT, given the prevalence therein of the SERT and the difficulty of labelling the DAT with the currently available ligands...
  5. doi request reprint Pharmacokinetics and pharmacodynamics of psychotropic drugs: effect of sex
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, University of Pisa, Pisa, Italy
    CNS Spectr 18:118-27. 2013
    ..Further studies are, however, necessary to explore more thoroughly the impact of sex on the pharmacokinetics and pharmacodynamics of psychotropic drugs, in order to reach the most appropriate and tailored prescription for each patient...
  6. ncbi request reprint The relationship between epilepsy and depression: an update
    M Catena-Dell'Osso
    Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Curr Med Chem 20:2861-7. 2013
    ..In spite of the large amount of data, several questions remain open and further studies are necessary to explore more thoroughly the complex and bidirectional relationships between epilepsy and depression. ..
  7. ncbi request reprint The role of platelet/lymphocyte serotonin transporter in depression and beyond
    Donatella Marazziti
    Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Via Roma 67, Pisa, Italy
    Curr Drug Targets 14:522-30. 2013
    ....
  8. ncbi request reprint Prefrontal cortex, dopamine, and jealousy endophenotype
    Donatella Marazziti
    Department of Psychiatry, University of Pisa, Pisa, Italy
    CNS Spectr 18:6-14. 2013
    ..In any case,empirical investigation of the neural bases of jealousy is just beginning, and further studies are strongly needed to elucidate the biological roots of this complex emotion...
  9. pmc The neurobiology of moral sense: facts or hypotheses?
    Donatella Marazziti
    Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Via Roma 67, Pisa, 56100, Italy
    Ann Gen Psychiatry 12:6. 2013
    ..Since converging observations outline how lesions of the proposed neural networks may underlie some personality changes and criminal behaviours, the implications of the studies in this field encompass many areas of the scientific domain...
  10. ncbi request reprint Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Curr Med Chem 20:371-7. 2013
    ..The present paper is a comprehensive review on the state of art of the 5-HT6 receptors, while highlighting the potential clinical applications of 5-HT6 receptor agonists/antagonists...
  11. doi request reprint [New developments on the serotonin hypothesis of depression: shunt of tryptophan]
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotechnologie, Universita di Pisa, Italy
    Riv Psichiatr 48:23-34. 2013
    ....
  12. doi request reprint Serotonin receptor of type 6 (5-HT6) in human prefrontal cortex and hippocampus post-mortem: an immunohistochemical and immunofluorescence study
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neurochem Int 62:182-8. 2013
    ..This study, taking into account all the limitations due to the postmortem model used, represents the starting point to explore the 5-HT(6) receptor functionality and its sub-cellular distribution...
  13. ncbi request reprint Latest advancements in the pharmacological treatment of binge eating disorder
    D Marazziti
    Department of Psychiatry, University of Pisa, Italy
    Eur Rev Med Pharmacol Sci 16:2102-7. 2012
    ..Binge-eating disorder (BED) is a relatively new disorder characterized by binge eating without purging...
  14. doi request reprint A link between oxytocin and serotonin in humans: supporting evidence from peripheral markers
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Eur Neuropsychopharmacol 22:578-83. 2012
    ....
  15. doi request reprint Plasma fluvoxamine levels and OCD symptoms/response in adult patients
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Hum Psychopharmacol 27:397-402. 2012
    ..In this study, we explored the possible relationships between plasma fluvoxamine levels and clinical features and/or response in adult obsessive-compulsive disorder (OCD) patients treated with this drug for 6 months...
  16. doi request reprint Distribution of serotonin receptor of type 6 (5-HT₆) in human brain post-mortem. A pharmacology, autoradiography and immunohistochemistry study
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Neurochem Res 37:920-7. 2012
    ..In addition, they would suggest that striatum is one of the major potential CNS targets linked to 5-HT(6) receptor modulation...
  17. ncbi request reprint Cognitive, psychological and psychiatric effects of ionizing radiation exposure
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Curr Med Chem 19:1864-9. 2012
    ....
  18. ncbi request reprint Psychiatric disorders and mitochondrial dysfunctions
    D Marazziti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology School of Medicine, University of Pisa, Pisa, Italy
    Eur Rev Med Pharmacol Sci 16:270-5. 2012
    ..The aim of this paper is to highlight the relationships between psychiatric disorders, especially schizophrenia, bipolar disorder (BD), autism, attention deficit-hyperactivity disorder (ADHD) and Alzheimer's dementia...
  19. ncbi request reprint Treatment strategies of obsessive-compulsive disorder and panic disorder/agoraphobia
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Curr Top Med Chem 12:238-53. 2012
    ....
  20. ncbi request reprint Augmentation strategy with olanzapine in resistant obsessive compulsive disorder: an Italian long-term open-label study
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    J Psychopharmacol 19:392-4. 2005
    ..The addition of olanzapine would appear to be a useful short- and long-term strategy for augmenting SRI effectiveness in resistant OCD patients, especially in those presenting comorbidity with bipolar disorders...
  21. ncbi request reprint Decreased density of peripheral benzodiazepine receptors in psychiatric patients after a suicide attempt
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67 I 56100 Pisa, Italy
    Life Sci 77:3268-75. 2005
    ....
  22. ncbi request reprint Presence and characterization of the dopamine transporter in human resting lymphocytes
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Neurochem Res 33:1011-6. 2008
    ..The pharmacological characterization of both binding and reuptake was overlapping. These findings would indicate that human resting lymphocytes carry the DAT, whose functions in periphery are still unknown...
  23. ncbi request reprint Romantic attachment in patients with mood and anxiety disorders
    Donatella Marazziti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
    CNS Spectr 12:751-6. 2007
    ..The aim of the present study was to compare romantic attachment styles among patients with different mood and anxiety disorders and control subjects...
  24. ncbi request reprint Thermal balneotherapy induces changes of the platelet serotonin transporter in healthy subjects
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 31:1436-9. 2007
    ....
  25. ncbi request reprint Presence of D4 dopamine receptors in human prefrontal cortex: a postmortem study
    Donatella Marazziti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
    Rev Bras Psiquiatr 29:148-52. 2007
    ..It was therefore necessary to devise a unique assay method in order to distinguish and detect the D4 component...
  26. ncbi request reprint Common alterations in the serotonin transporter in platelets and lymphocytes of psychotic patients
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Pharmacopsychiatry 39:35-8. 2006
    ....
  27. ncbi request reprint Insight in body dysmorphic disorder with and without comorbid obsessive-compulsive disorder
    Donatella Marazziti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
    CNS Spectr 11:494-8. 2006
    ..The aim of this study was to compare the level of insight in patients with body dysmorphic disorder (BDD) with and without comorbid obsessive-compulsive disorder (OCD), and to measure its possible relationships with clinical features...
  28. ncbi request reprint Effectiveness of risperidone in psychogenic stiff neck
    Donatella Marazziti
    Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy
    CNS Spectr 10:443-4. 2005
    ..This case report suggests that risperidone may be effective in some neurological motor disorders comorbid with mood disorders...
  29. ncbi request reprint Mitochondrial alterations and neuropsychiatric disorders
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Curr Med Chem 18:4715-21. 2011
    ....
  30. doi request reprint Treatment strategies for obsessive-compulsive disorder
    Donatella Marazziti
    University of Pisa, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Via Roma 67, 56100 Pisa, Italy
    Expert Opin Pharmacother 11:331-43. 2010
    ....
  31. doi request reprint Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Psychiatry Res 175:54-7. 2010
    ..These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures...
  32. ncbi request reprint Second messenger modulation: a novel target of future antidepressants?
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, 56100 Pisa, Italy
    Curr Med Chem 16:4679-90. 2009
    ....
  33. doi request reprint Cognitive impairment in major depression
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Eur J Pharmacol 626:83-6. 2010
    ....
  34. doi request reprint [(3)H]-YM-09151-2 binding sites in human brain postmortem
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neurochem Int 55:643-7. 2009
    ..In conclusion, these findings underline that it is possible to label D(4) receptors by means of [(3)H]-YM-09151-2, provided that D(2), D(3) and sigma receptors are blocked...
  35. ncbi request reprint Heterogeneity of the jealousy phenomenon in the general population: an Italian study
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    CNS Spectr 15:19-24. 2010
    ..Despite the general agreement that normal jealousy is heterogenous, little is known about this specific topic...
  36. ncbi request reprint Past, present and future drugs for the treatment of obsessive-compulsive disorder
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Curr Med Chem 17:3410-21. 2010
    ....
  37. ncbi request reprint Is androstadienone a putative human pheromone?
    D Marazziti
    Dipartimento di Psichiatria Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Med Chem 18:1213-9. 2011
    ..The aim of this paper is to review all relevant data regarding androstadienone, in order to ascertain whether it may be considered a physiological pheromone and, as such, a possible target of future modulators of some human behaviors...
  38. ncbi request reprint Effectiveness of long-term augmentation with citalopram to clomipramine in treatment-resistant OCD patients
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    CNS Spectr 13:971-6. 2008
    ..The meager information available on the association of two serotonergic drugs prompted us to explore the possible effectiveness and tolerability of citalopram+clomipramine in resistant OCD patients...
  39. ncbi request reprint Serotonin receptors of type 6 (5-HT6): what can we expect from them?
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Curr Med Chem 18:2783-90. 2011
    ..Therefore, with the present paper we aimed at reporting a comprehensive review on the status of art of the 5-HT6 receptors, while highlighting the potential clinical applications of 5-HT6 receptor agonists/antagonists...
  40. doi request reprint Decreased density of the platelet serotonin transporter in pathological gamblers
    Donatella Marazziti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
    Neuropsychobiology 57:38-43. 2008
    ....
  41. pmc Executive function abnormalities in pathological gamblers
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Clin Pract Epidemiol Ment Health 4:7. 2008
    ..Our study aimed to evaluate a group of patients suffering from PG by means of some neuropsychological tests in order to explore the brain areas related to the disorder...
  42. ncbi request reprint The role of oxytocin in neuropsychiatric disorders
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Curr Med Chem 15:698-704. 2008
    ....
  43. ncbi request reprint Novel treatment options of binge eating disorder
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Curr Med Chem 18:5159-64. 2011
    ..In addition, the preliminary findings on the possibility of modulating appetite through the interference with the ghrelin system suggest new and intriguing ways of intervention in BED...
  44. doi request reprint Male axillary extracts modify the affinity of the platelet serotonin transporter and impulsiveness in women
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Physiol Behav 100:364-8. 2010
    ..The substances responsible for this effect remain to be identified...
  45. ncbi request reprint Absence of NK1 receptors in human blood lymphocytes and granulocytes
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Neuropsychobiology 50:221-5. 2004
    ..These findings would question the presence of NK1 receptors in human circulating cells...
  46. ncbi request reprint Decreased platelet [3H]paroxetine binding sites in suicide attempters
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    Psychiatry Res 103:125-31. 2001
    ..The results, showing a decreased number of [3H]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior...
  47. ncbi request reprint Pharmacological characterization of the serotonin transporter in young and elderly subjects
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neuropsychobiology 44:78-83. 2001
    ....
  48. ncbi request reprint Citalopram in refractory obsessive-compulsive disorder: an open study
    D Marazziti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
    Int Clin Psychopharmacol 16:215-9. 2001
    ..The use of citalopram would appear to be an useful strategy in refractory OCD cases...
  49. ncbi request reprint Increased density of the platelet serotonin transporter in autism
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Pharmacopsychiatry 33:165-8. 2000
    ....
  50. ncbi request reprint Increased inhibitory activity of protein kinase C on the serotonin transporter in OCD
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neuropsychobiology 41:171-7. 2000
    ..These findings could indicate the presence of hyperactivity of PKC in OCD that could be the result of increased activity of the phosphatidylinositol pathway. In addition, this suggests new potential therapeutic targets in OCD...
  51. ncbi request reprint Platelet [3H]paroxetine binding in patients with OCD-related disorders
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Psychiatry Res 89:223-8. 1999
    ....
  52. ncbi request reprint Distribution and characterization of [3H]mesulergine binding in human brain postmortem
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotechnologie, University of Pisa, Italy
    Eur Neuropsychopharmacol 10:21-6. 1999
    ..These findings, showing a wide distribution of [3H]mesulergine binding sites in the human brain, could provide anatomical bases for the different functions attributable to 5-HT2C receptors in humans...
  53. ncbi request reprint Decreased platelet 3H-paroxetine binding in untreated panic disorder patients
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Life Sci 65:2735-41. 1999
    ..This abnormality reverted after one year of treatment with specific drugs that provoked the symptom remission in all cases, which would suggest a link with the clinical improvement...
  54. ncbi request reprint Prevalence of headache syndromes in panic disorder
    D Marazziti
    Dipartimento di Psichiatria, University of Pisa, Italy
    Int Clin Psychopharmacol 14:247-51. 1999
    ..This suggests that the comorbidity of headache with panic disorder renders this condition more severe and possibly responsive to different treatments compared to panic disorder alone...
  55. ncbi request reprint Effect of aging and sex on the [3H]-paroxetine binding to human platelets
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotechnologie, University of Pisa, Italy
    J Affect Disord 50:11-5. 1998
    ..This might indicate modifications in the 5-HT transporter that could form the basis of a sex-related difference in vulnerability to disorders, such as depression, where a dysfunction at this level is hypothesized...
  56. ncbi request reprint Platelet sulfotransferase in different psychiatric disorders
    D Marazziti
    Institute of Psychiatry, University of Pisa, Italy
    Psychiatry Res 65:73-8. 1996
    ..It would therefore seem that different neuropsychiatric disorders are associated with different levels of PST activity...
  57. ncbi request reprint Latest advancements on serotonin and dopamine transporters in lymphocytes
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, Pisa, Italy
    Mini Rev Med Chem 10:32-40. 2010
    ..This papers aims to review most of the available literature on this topic, while highlighting the possible role of SERT and DAT, as well as that of their substrates including antidepressants on the immune system...
  58. ncbi request reprint Correlation between platelet alpha(2)-adrenoreceptors and symptom severity in major depression
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neuropsychobiology 44:122-5. 2001
    ..The presence of alpha(2)-adrenoreceptors in blood platelets, similar to those in the brain, prompted us to evaluate them in depressed patients, as compared with healthy controls...
  59. ncbi request reprint Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Universita di Pisa, Italy
    Int J Neuropsychopharmacol 5:131-40. 2002
    ..These findings suggest a region-related action of flibanserin and buspirone on forskolin-stimulated AC activity in human brain...
  60. ncbi request reprint Hormonal changes when falling in love
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Psychoneuroendocrinology 29:931-6. 2004
    ..In conclusion, the findings of the present study would indicate that to fall in love provokes transient hormonal changes some of which seem to be specific to each sex...
  61. ncbi request reprint Platelet alpha2-adrenoreceptors in obsessive-compulsive disorder
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Pisa, Italy
    Neuropsychobiology 49:81-3. 2004
    ....
  62. doi request reprint Normalisation of immune cell imbalance after pharmacological treatments of patients suffering from obsessive-compulsive disorder
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa 56100, Italy
    J Psychopharmacol 23:567-73. 2009
    ..These data suggest that the alterations of immune cells reported in patients with OCD at baseline may be reverted by treatment with SRIs and should be considered a state-dependent marker, perhaps related to a condition of stress...
  63. ncbi request reprint Venlafaxine treatment of obsessive-compulsive disorder: case reports
    Donatella Marazziti
    Department of Psychiatry, Section of Psychiatry, University of Pisa, Pisa, Italy
    CNS Spectr 8:421-2. 2003
    ..This article reports experiences with venlafaxine in patients with obsessive-compulsive disorder who did not respond or did not tolerate serotonergic drugs...
  64. ncbi request reprint No correlation between aggression and platelet (3)H-paroxetine binding in obsessive-compulsive disorder patients
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neuropsychobiology 43:117-22. 2001
    ..This suggests that aggression in OCD is a complex phenomenon that probably requires specific instruments of evaluation...
  65. ncbi request reprint Normal and obsessional jealousy: a study of a population of young adults
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Eur Psychiatry 18:106-11. 2003
    ..Jealousy is a heterogenous emotion ranging from normality to pathology. Several problems still exist in the distinction between normal and pathological jealousy...
  66. ncbi request reprint Decreased lymphocyte 3H-paroxetine binding in obsessive-compulsive disorder
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Neuropsychobiology 47:128-30. 2003
    ....
  67. ncbi request reprint Decreased inhibitory activity of PKC in OCD patients after six months of treatment
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Psychoneuroendocrinology 27:769-76. 2002
    ..These findings could indicate that, in OCD patients, SRIs increase the rate of reuptake and decrease the inhibitory effect of PKC and that the two phenomena may be linked, the first perhaps depending upon the second...
  68. ncbi request reprint [3H]-ketanserin binding sites in different psychiatric disorders
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Neurochem Int 42:511-6. 2003
    ....
  69. ncbi request reprint Jealousy and subthreshold psychopathology: a serotonergic link
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, I 56100 Pisa, Italy
    Neuropsychobiology 47:12-6. 2003
    ....
  70. ncbi request reprint Kleptomania in impulse control disorders, obsessive-compulsive disorder, and bipolar spectrum disorder: clinical and therapeutic implications
    Donatella Marazziti
    Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Via Rome 67, Italy
    Curr Psychiatry Rep 5:36-40. 2003
    ..This paper aims to critically review currently available data on kleptomania and to analyze the possible future evolution of clinical research and therapeutic strategies...
  71. doi request reprint Plasma clomipramine levels in adult patients with obsessive-compulsive disorder
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Int Clin Psychopharmacol 27:55-60. 2012
    ..These findings would highlight the potential impact of assessing clomipramine plasma levels and their relationships with specific symptoms, as well as the influence of the sex on the drug response...
  72. ncbi request reprint Lack of stereoselectivity of 8-hydroxy-2(di-N-propylamino)tetralin-mediated inhibition of forskolin-stimulated adenylyl cyclase activity in human pre- and post-synaptic brain regions
    L Palego
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neurochem Int 36:225-32. 2000
    ..Moreover, such results have significant implication, as they support the notion that human 5-HT1A receptors might vary from one brain region to the other...
  73. ncbi request reprint Obsessive-compulsive disorder in childhood and adolescence
    S Presta
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Roma 67, I 56100 Pisa, Italy
    Psychopathology 36:55-64. 2003
    ..The aim of this paper is to present a critical review of paediatric OCD, with a special attention towards the most compelling reports available up to now and towards the most interesting areas for future research...
  74. doi request reprint Patterns of caffeine consumption in psychiatric patients. An Italian study
    A Ciapparelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    Eur Psychiatry 25:230-5. 2010
    ..The aim of the present study was to explore and compare the caffeine intake, intoxication, withdrawal and dependence prevalence in Italian psychiatric patients and healthy subjects...
  75. ncbi request reprint Gender and age-related variation in adenylyl cyclase activity in the human prefrontal cortex, hippocampus and dorsal raphe nuclei
    L Palego
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neurosci Lett 279:53-6. 2000
    ..Overall, the findings suggest that sex and/or age-related differences in brain adenylyl cyclase vary from one cerebral region to the other...
  76. ncbi request reprint Platelet imipramine binding in intensive care unit suicidal patients
    D De Leo
    Department of Psychiatry, University of Padua, School of Medicine, Italy
    Eur Arch Psychiatry Clin Neurosci 241:85-7. 1991
    ..Although it is impossible to attribute a suicidal attempt to the alteration or to a predisposing pre-existent condition, this biological marker may be useful in evaluating suicidal risk and also short- and long-term prognosis...
  77. ncbi request reprint Inflammatory and neurodegenerative pathways in depression: a new avenue for antidepressant development?
    M Catena-Dell'Osso
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Curr Med Chem 18:245-55. 2011
    ....
  78. ncbi request reprint Simultaneous analysis of clozapine, clomipramine and their metabolites by reversed-phase liquid chromatography
    L Palego
    Department of Psychiatry, University of Pisa, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 25:519-33. 2001
    ..The simultaneous evaluation of these two drugs with adequate sensitivity and precision makes it particularly useful for therapeutic drug monitoring during mono- or polypharmacotherapy...
  79. ncbi request reprint Comorbidity with axis I anxiety disorders in remitted psychotic patients 1 year after hospitalization
    Antonio Ciapparelli
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
    CNS Spectr 12:913-9. 2007
    ..Comorbid anxiety disorders are frequently encountered in psychoses and mainly assessed during the hospitalization...
  80. ncbi request reprint Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron
    Massimo Bellini
    Section of Gastroenterology, Department of Internal Medicine, University of Pisa, Ospedale Santa Chiara, Via Roma 67, 56126 Pisa, Italy
    Am J Gastroenterol 98:2705-11. 2003
    ....
  81. ncbi request reprint Kleptomania: clinical features and comorbidity in an Italian sample
    Silvio Presta
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Compr Psychiatry 43:7-12. 2002
    ..Family history also showed a high prevalence of psychiatric disorders. Our study indicates clear connections between kleptomania and different psychiatric disorders, the exact nature of which has yet to be clarified...
  82. ncbi request reprint mRNA expression of serotonin receptors of type 2C and 5A in human resting lymphocytes
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy
    Neuropsychobiology 43:123-6. 2001
    ..These findings, while revealing the presence of 5-HT(2C) and 5-HT(5A) receptor mRNAs in an easily available tissue, can be considered preliminary for future quantitative analyses in patients with different psychiatric conditions...
  83. ncbi request reprint Health-related quality of life and functioning in remitted bipolar I outpatients
    Armando Piccinni
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, 56127 Pisa, Italy
    Compr Psychiatry 48:323-8. 2007
    ..An affectively biased cognition may explain the gap between patient's perception of functioning and estimated functional adjustment, as assessed by clinicians...
  84. ncbi request reprint Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments
    Armando Piccinni
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    J Affect Disord 105:279-83. 2008
    ..The aim of this study was to assess the possible relationships between depressive symptoms and serum and/or plasma BDNF levels during 1 year of antidepressant treatment...
  85. ncbi request reprint Serotonergic activity measured by platelet [3H]paroxetine binding in patients with eating disorders
    Carla E Ramacciotti
    Department of Psychiatry, Pharmacology, Neurobiology and Biotechnologies, Section of Psychiatry, University of Pisa, Italy
    Psychiatry Res 118:33-8. 2003
    ..Although ED patients share a dysregulation in serotonergic activity, DSM-IV subtype classification was not validated by [3H]paroxetine binding, and hence does not correspond to a specific 5-HT profile...
  86. doi request reprint Plasma Brain-Derived Neurotrophic Factor in treatment-resistant depressed patients receiving electroconvulsive therapy
    Armando Piccinni
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, Pisa, Italy
    Eur Neuropsychopharmacol 19:349-55. 2009
    ..These findings would suggest the potential usefulness of baseline plasma BDNF levels as predictors of response to ECT in treatment-resistant depressed patients...
  87. ncbi request reprint Lifetime subthreshold mania is related to suicidality in posttraumatic stress disorder
    Liliana Dell'Osso
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    CNS Spectr 14:262-6. 2009
    ..The aim of the present study was, thus, to explore the frequency and relationship between subthreshold mood symptoms, assessed by a specific and validated questionnaire, and suicidality in PTSD patients...
  88. ncbi request reprint Lymphocyte subsets, cardiovascular measures and anxiety state before and after a professional examination
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa Via Roma, 67, Pisa, 56100 Italy
    Stress 10:93-9. 2007
    ..However, individual differences, related to both sex and personality traits yet to be identified, seem to have an impact in shaping the stress response...
  89. doi request reprint Switching from serotonin reuptake inhibitors to duloxetine in patients with resistant obsessive compulsive disorder: a case series
    Bernardo Dell'Osso
    Department of Psychiatry, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Psychopharmacol 22:210-3. 2008
    ..Duloxetine may be helpful in patients with treatment-resistant OCD, although larger and controlled studies are warranted to confirm this preliminary observation...
  90. ncbi request reprint Analgesia by nefopam: does it act through serotonin?
    D Marazziti
    Institute of the Psychiatric Clinic, University of Pisa, Italy
    Drugs Exp Clin Res 17:259-61. 1991
    ..This finding suggests a possible intervention of serotonergic mechanisms in nefopam-related analgesia...
  91. doi request reprint Diurnal variation of plasma brain-derived neurotrophic factor (BDNF) in humans: an analysis of sex differences
    Armando Piccinni
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Chronobiol Int 25:819-26. 2008
    ..These findings support the concept of rhythmic variation in plasma BDNF regulation that seems to be sex-related...
  92. ncbi request reprint The rabbit syndrome: state of the art
    Mario Catena
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    Curr Clin Pharmacol 2:212-6. 2007
    ....
  93. doi request reprint Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder
    Liliana Dell'Osso
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 33:899-902. 2009
    ..001), although obtained in a small sample size, would suggest that this NT may be involved in the pathophysiology of PTSD...
  94. pmc Epidemiologic and clinical updates on impulse control disorders: a critical review
    Bernardo Dell'Osso
    Compulsive, Impulsive and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA
    Eur Arch Psychiatry Clin Neurosci 256:464-75. 2006
    ..Particular attention is paid to the relationship between ICDs and obsessive-compulsive disorder (OCD). Finally, current pharmacological options for treating ICDs are presented and discussed...
  95. ncbi request reprint Treatment non-response in OCD: methodological issues and operational definitions
    Stefano Pallanti
    Mount Sinai School of Medicine, New York, NY, USA
    Int J Neuropsychopharmacol 5:181-91. 2002
    ..Better characterization of which patients respond and do not respond to various treatments will enable more accurate clustering of patients, and help facilitate multi-site data collection for future research trials...
  96. ncbi request reprint Refractory obsessive-compulsive disorder: state-of-the-art treatment
    Eric Hollander
    Department of Psychiatry, Compulsive, Impulsive, and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 63:20-9. 2002
    ..The authors synthesize state-of-the-art treatment and give practical advice for clinicians...
  97. ncbi request reprint WCA recommendations for the long-term treatment of obsessive-compulsive disorder in adults
    John H Greist
    Healthcare Technology Systems, Inc, Madison, Wisconsin 53717, USA
    CNS Spectr 8:7-16. 2003
    ..Further, pharmacotherapy for a minimum of 1-2 years is recommended before very gradual withdrawal may be considered...
  98. ncbi request reprint A further support to the hypothesis of a link between serotonin, autism, and the cerebellum
    Donatella Marazziti
    Biol Psychiatry 52:143; author reply 143. 2002