G Mantovani

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint GNAS epigenetic defects and pseudohypoparathyroidism: time for a new classification?
    G Mantovani
    Department of Medical Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Horm Metab Res 44:716-23. 2012
  2. doi request reprint Filamin-A is essential for dopamine d2 receptor expression and signaling in tumorous lactotrophs
    Erika Peverelli
    Endocrinology Unit, Department of Medical Sciences, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico Ca Granda Padiglione Granelli, University of Milan, Via Francesco Sforza, 35, 20122 Milan, Italy
    J Clin Endocrinol Metab 97:967-77. 2012
  3. ncbi request reprint Somatic mutational analysis of DAX1 in testes from men with idiopathic azoospermia
    Giovanna Mantovani
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
    Fertil Steril 84:1542-4. 2005
  4. ncbi request reprint DAX1 and X-linked adrenal hypoplasia congenita: clinical and molecular analysis in five patients
    Giovanna Mantovani
    Institute of Endocrine Sciences, University of Milan, Padiglione Granelli, Ospedale Maggiore IRCCS, Via F Sforza 35, 20122 Milan, Italy
    Eur J Endocrinol 154:685-9. 2006
  5. doi request reprint Recombinant human GH replacement therapy in children with pseudohypoparathyroidism type Ia: first study on the effect on growth
    Giovanna Mantovani
    Endocrinology Unit, Department of Medical Sciences, University of Milan, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico Ca Granda Policlinico, Milan, Italy
    J Clin Endocrinol Metab 95:5011-7. 2010
  6. ncbi request reprint Mutations in the Gs alpha gene causing hormone resistance
    Giovanna Mantovani
    Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena IRCCS, Via F Sforza, 35, 20122 Milan, Italy
    Best Pract Res Clin Endocrinol Metab 20:501-13. 2006
  7. doi request reprint Clinical review: Pseudohypoparathyroidism: diagnosis and treatment
    Giovanna Mantovani
    Endocrinology and Diabetology Unit, Department of Medical Sciences, Universita degli Studi di Milano, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    J Clin Endocrinol Metab 96:3020-30. 2011
  8. pmc Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjects
    Giovanna Mantovani
    Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    Diabetes 58:620-6. 2009
  9. ncbi request reprint Genetic analysis and evaluation of resistance to thyrotropin and growth hormone-releasing hormone in pseudohypoparathyroidism type Ib
    Giovanna Mantovani
    Department of Medical Sciences, Endocrine Unit, Fondazione Policlinico Instituto di Ricovero e Cura a Carattere Scientifico, University of Milan, 20122 Milan, Italy
    J Clin Endocrinol Metab 92:3738-42. 2007
  10. doi request reprint Pseudohypoparathyroidism and GNAS epigenetic defects: clinical evaluation of albright hereditary osteodystrophy and molecular analysis in 40 patients
    Giovanna Mantovani
    Unità di Endocrinologia, Padiglione Granelli, Fondazione Ospedale Maggiore Instituto di Ricovero e Cura a Carattere Scientifico, Via Francesco Sforza, 35, 20122 Milano, Italy
    J Clin Endocrinol Metab 95:651-8. 2010

Detail Information

Publications45

  1. doi request reprint GNAS epigenetic defects and pseudohypoparathyroidism: time for a new classification?
    G Mantovani
    Department of Medical Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Horm Metab Res 44:716-23. 2012
    ....
  2. doi request reprint Filamin-A is essential for dopamine d2 receptor expression and signaling in tumorous lactotrophs
    Erika Peverelli
    Endocrinology Unit, Department of Medical Sciences, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico Ca Granda Padiglione Granelli, University of Milan, Via Francesco Sforza, 35, 20122 Milan, Italy
    J Clin Endocrinol Metab 97:967-77. 2012
    ..Recently, D2R was found to associate with filamin-A (FLNA), a widely expressed cytoskeleton protein with scaffolding properties, in melanoma and neuronal cells...
  3. ncbi request reprint Somatic mutational analysis of DAX1 in testes from men with idiopathic azoospermia
    Giovanna Mantovani
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
    Fertil Steril 84:1542-4. 2005
    ..We conclude that somatic abnormalities in DAX1 are absent or uncommon in these patients...
  4. ncbi request reprint DAX1 and X-linked adrenal hypoplasia congenita: clinical and molecular analysis in five patients
    Giovanna Mantovani
    Institute of Endocrine Sciences, University of Milan, Padiglione Granelli, Ospedale Maggiore IRCCS, Via F Sforza 35, 20122 Milan, Italy
    Eur J Endocrinol 154:685-9. 2006
    ..The aim of this study was to characterize clinically and genetically five patients with AHC...
  5. doi request reprint Recombinant human GH replacement therapy in children with pseudohypoparathyroidism type Ia: first study on the effect on growth
    Giovanna Mantovani
    Endocrinology Unit, Department of Medical Sciences, University of Milan, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico Ca Granda Policlinico, Milan, Italy
    J Clin Endocrinol Metab 95:5011-7. 2010
    ....
  6. ncbi request reprint Mutations in the Gs alpha gene causing hormone resistance
    Giovanna Mantovani
    Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena IRCCS, Via F Sforza, 35, 20122 Milan, Italy
    Best Pract Res Clin Endocrinol Metab 20:501-13. 2006
    ..This review will focus on inactivating mutations leading to hormone resistance syndromes, i.e., pseudohypoparathyroidism types Ia and Ib...
  7. doi request reprint Clinical review: Pseudohypoparathyroidism: diagnosis and treatment
    Giovanna Mantovani
    Endocrinology and Diabetology Unit, Department of Medical Sciences, Universita degli Studi di Milano, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    J Clin Endocrinol Metab 96:3020-30. 2011
    ..The two main subtypes of PHP, PHP type Ia, and Ib (PHP-Ia, PHP-Ib) are caused by molecular alterations within or upstream of the imprinted GNAS gene, which encodes Gsα and other translated and untranslated products...
  8. pmc Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjects
    Giovanna Mantovani
    Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    Diabetes 58:620-6. 2009
    ..The aim of the study was to investigate possible differences in R2B expression, PKA activity, and lipolysis in adipose tissues from obese and nonobese subjects...
  9. ncbi request reprint Genetic analysis and evaluation of resistance to thyrotropin and growth hormone-releasing hormone in pseudohypoparathyroidism type Ib
    Giovanna Mantovani
    Department of Medical Sciences, Endocrine Unit, Fondazione Policlinico Instituto di Ricovero e Cura a Carattere Scientifico, University of Milan, 20122 Milan, Italy
    J Clin Endocrinol Metab 92:3738-42. 2007
    ..No study addressed the question of GH deficiency in PHP-Ib patients...
  10. doi request reprint Pseudohypoparathyroidism and GNAS epigenetic defects: clinical evaluation of albright hereditary osteodystrophy and molecular analysis in 40 patients
    Giovanna Mantovani
    Unità di Endocrinologia, Padiglione Granelli, Fondazione Ospedale Maggiore Instituto di Ricovero e Cura a Carattere Scientifico, Via Francesco Sforza, 35, 20122 Milano, Italy
    J Clin Endocrinol Metab 95:651-8. 2010
    ....
  11. doi request reprint Analysis of GNAS1 and PRKAR1A gene mutations in human cardiac myxomas not associated with multiple endocrine disorders
    G Mantovani
    Endocrine Unit, Department of Medical Sciences, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, 20122 Milan, Italy
    J Endocrinol Invest 32:501-4. 2009
    ..This is the first study including a large series of sporadic, isolated cardiac myxomas and showing that these cardiac neoplasms do not share the same mutations found in familial forms...
  12. ncbi request reprint HESX1 expression in human normal pituitaries and pituitary adenomas
    G Mantovani
    Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
    Mol Cell Endocrinol 247:135-9. 2006
    ..This is the first study on HESX1 expression in humans during adult life...
  13. ncbi request reprint Modulation of cyclin D1 expression in human tumoral parathyroid cells: effects of growth factors and calcium sensing receptor activation
    S Corbetta
    Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, Policlinico SDonato IRCCS, Via Morandi 30, 20097, SDonato Mse MI, Italy
    Cancer Lett 255:34-41. 2007
    ..These data further support the oncogenic role of cyclin D1, which resulted to be target for stimulation by bFGF and EGF and inhibition by CaSR and TGFbeta signalling in the parathyroid...
  14. ncbi request reprint Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation
    G Mantovani
    Department of Medical Sciences, University of Milan, Fondazione Policlinico IRCCS, Milan, Italy
    Exp Cell Res 314:123-30. 2008
    ..In conclusion, we propose that a high R1/R2 ratio favors the proliferation of well differentiated and hormone producing adrenocortical cells, while unbalanced expression of these subunits is not required for malignant transformation...
  15. ncbi request reprint Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas
    L Persani
    Institute of Endocrine Sciences, University of Milan, Istituto Auxologico Italiano IRCCS
    J Clin Endocrinol Metab 85:2872-8. 2000
    ....
  16. ncbi request reprint Evaluation of proopiomelanocortin mRNA in the peripheral blood from patients with Cushing's syndrome of different origin
    S Bondioni
    Endocrine Unit, Department of Medical Sciences, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, University of Milan, Milan, Italy
    J Endocrinol Invest 30:828-32. 2007
    ..These data were confirmed by the more sensitive RT-PCR technique. This study further underlines the need for alternative approaches in the diagnosis of ACTH-dependent Cushing's syndrome...
  17. ncbi request reprint Absence of thyroid transcription factor-1 expression in human parathyroid and pituitary glands
    G Mantovani
    Institute of Endocrine Sciences, University of Milan-Ospedale Maggiore IRCCS, Pad. Granelli, Via Francesco Sforza 35, 21022 Milan, Italy
    Mol Cell Endocrinol 182:13-7. 2001
    ....
  18. ncbi request reprint Effect of cyclic adenosine 3',5'-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas
    G Mantovani
    Institute of Endocrine Sciences, Ospedale Maggiore, IRCCS, University of Milan, Italy
    J Clin Endocrinol Metab 90:6721-4. 2005
    ..In particular, activating mutations of the G(s)alpha gene and protein kinase A (PKA) overactivity due to low expression of PKA regulatory subunit 1A (R1A) have been implicated in somatotroph proliferation...
  19. doi request reprint Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients
    E Peverelli
    Endocrinology and Diabetology Unit, Department of Medical Sciences, University of Milan, Padiglione Granelli, Fondazione Ospedale Maggiore IRCCS, Via F Sforza, 35, 20122 Milan, Italy
    Eur J Endocrinol 161:687-94. 2009
    ..The aim of the study was to screen acromegalic patients for the presence of variants of phosphodiesterase type 11A (PDE11A) gene, which have been recently identified in adrenocortical and testicular tumors...
  20. ncbi request reprint Gonadotropin-releasing hormone initiates multiple signaling pathways in human GH-secreting adenomas
    A Lania
    Institute of Endocrine Sciences, Milan, Italy
    J Endocrinol Invest 27:328-33. 2004
    ..The ability of GnRH to signal through Gsalpha protein may account for the lack of GH responses to GnRH observed in acromegalic patients with tumors carrying gsp mutation...
  21. ncbi request reprint Somatostatin receptor subtype 2 and 5 in human GH-secreting pituitary adenomas: analysis of gene sequence and mRNA expression
    S Corbetta
    Ospedale Maggiore IRCCS, University of Milan, San Raffaele IRCCS, Via Francesco Sforza 35, 21022 Milan, Italy
    Eur J Clin Invest 31:208-14. 2001
    ..Moreover, both SSTR2 and SSTR5 DNA from tumours resistant to somatostatin analogues were found to possess intact coding sequences...
  22. ncbi request reprint High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells
    G Mantovani
    Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore IRCCS, Milan, Italy
    Oncogene 27:1834-43. 2008
    ....
  23. doi request reprint Growth hormone receptor variants and response to pegvisomant in monotherapy or in combination with somatostatin analogs in acromegalic patients: a multicenter study
    M Filopanti
    University of Milan, Department of Medical Sciences, Via F Sforza, 35, Milan 20122, Italy
    J Clin Endocrinol Metab 97:E165-72. 2012
    ..The influence of full-length GH receptor (GHR) and exon 3-deleted GHR (d3GHR) on responsiveness to pegvisomant (PEG-V) in acromegalic patients is uncertain...
  24. ncbi request reprint Genetic abnormalities of somatostatin receptors in pituitary tumors
    A Lania
    Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore IRCCS, Milan, Italy
    Mol Cell Endocrinol 286:180-6. 2008
    ..Nevertheless, polymorphic variants in SST2 and SST5 genes seem to have a minor, if any, role in determining the different responsiveness to somatostatin analogs in patients with acromegaly...
  25. ncbi request reprint Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations
    L Persani
    Institute of Endocrine Sciences, University of Milan, Istituto Auxologico Italiano IRCCS, Milan 20145, Italy
    J Clin Endocrinol Metab 86:3795-800. 2001
    ....
  26. ncbi request reprint Activity and function of the nuclear factor kappaB pathway in human parathyroid tumors
    S Corbetta
    Institute of Endocrine Sciences, Fondazione Ospedale Maggiore IRCCS, University of Milan, Italy
    Endocr Relat Cancer 12:929-37. 2005
    ....
  27. ncbi request reprint Mutational analysis of PRKAR1A and Gs(alpha) in sporadic adrenocortical tumors
    R Libe
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
    Exp Clin Endocrinol Diabetes 113:248-51. 2005
    ..In conclusion, we provide additional evidence that the only mutational changes able to activate the cAMP pathway so far identified, i.e. PRKAR1A mutations and gsp oncogene, are a rare event in adrenocortical tumors...
  28. ncbi request reprint Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2
    E Ferrante
    Institute of Endocrine Sciences, University of Milan, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via Francesco Sforza 35, 20122 Milan, Italy
    Endocr Relat Cancer 13:955-62. 2006
    ..This effect, together with the cytostatic action exerted by both SST2 and SST5 analogs, might account for the tumor shrinkage observed in acromegalic patients treated with long-acting somatostatin analogs...
  29. doi request reprint Role of UGT1A1 and ADH gene polymorphisms in pegvisomant-induced liver toxicity in acromegalic patients
    M Filopanti
    Endocrinology and Diabetology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Padiglione Granelli via F Sforza 35, 20122 Milan, Italy
    Eur J Endocrinol 170:249-56. 2014
    ..Recent studies have found an association between this adverse event and the UGT1A1 allele 28 polymorphism associated with Gilbert's syndrome...
  30. ncbi request reprint Assessing the presence of abnormal regulation of cortisol secretion by membrane hormone receptors: in vivo and in vitro studies in patients with functioning and non-functioning adrenal adenoma
    C Dall'Asta
    Istituto di Scienze Endocrine, Universita degli Studi di Milano, Ospedale Maggiore IRCCS, Italia
    Horm Metab Res 36:578-83. 2004
    ..The finding of receptor expression in normal and non-responsive tumors suggests that different mechanisms are probably involved in inducing in vivo cortisol responses...
  31. ncbi request reprint Patients with macroprolactinaemia: clinical and radiological features
    F Donadio
    Department of Medical Sciences, University of Milan, Unit of Endocrinology and Diabetology, Fondazione Ospedale Maggiore IRCCS, Milan, Italy
    Eur J Clin Invest 37:552-7. 2007
    ....
  32. doi request reprint Cyclic adenosine 3'-5'-monophosphate (cAMP) exerts proliferative and anti-proliferative effects in pituitary cells of different types by activating both cAMP-dependent protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac)
    E Vitali
    Endocrine Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Italy
    Mol Cell Endocrinol 383:193-202. 2014
    ..In conclusion, we demonstrated that cAMP exerted opposite effects on different pituitary cell types proliferation, these effects being mediated by both Epac and PKA. ..
  33. doi request reprint The trans-sphenoidal resection of pituitary adenomas in elderly patients and surgical risk
    M Locatelli
    Neurosurgery Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Pad Monteggia, Via F Sforza 35, 20122 Milan, Italy
    Pituitary 16:146-51. 2013
    ..In conclusion, in specialized centres the surgical treatment of pituitary adenomas via the transsphenoidal route can be a safe and effective procedure even in elderly patients...
  34. ncbi request reprint Mutational analysis of GNAS1 in patients with pseudohypoparathyroidism: identification of two novel mutations
    G Mantovani
    Ospedale Maggiore IRCCS, Institute of Endocrine Sciences, University of Milan, Italy
    J Clin Endocrinol Metab 85:4243-8. 2000
    ..Furthermore, we confirm that these mutations cannot be detected in families with isolated PPHP, suggesting that these forms of AHO are genetically distinct from PHP Ia...
  35. doi request reprint GNAS imprinting and pituitary tumors
    G Mantovani
    Department of Medical Sciences, Endocrinology and Diabetology Unit, Universita degli Studi di Milano, Fondazione Ca Granda Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    Mol Cell Endocrinol 326:15-8. 2010
    ..Therefore, genetic and epigenetic alterations of the GNAS gene, with subsequent dysregulation of the cAMP pathway, appear, to date, the only molecular hallmark of most GH-secreting adenomas...
  36. ncbi request reprint Inactivating and activating mutations of the Gs alpha gene
    A Spada
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Via F Sforza 35 20122 Milano Italy
    Ann Endocrinol (Paris) 66:258-63. 2005
  37. doi request reprint Screening for GNAS genetic and epigenetic alterations in progressive osseous heteroplasia: first Italian series
    F M Elli
    Department of Clinical Sciences and Community Health, University of Milan, Endocrinology and Diabetology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milano, Italy
    Bone 56:276-80. 2013
    ....
  38. ncbi request reprint Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia
    S Corbetta
    Institute of Endocrine Sciences, University of Milan, Milan, Italy
    Clin Endocrinol (Oxf) 52:339-48. 2000
    ....
  39. doi request reprint Dopamine D2 receptor gene polymorphisms and response to cabergoline therapy in patients with prolactin-secreting pituitary adenomas
    M Filopanti
    Department of Medical Sciences, University of Milan, Endocrine and Diabetes Unit Fondazione Ospedale Maggiore IRCCS, Milan, Italy
    Pharmacogenomics J 8:357-63. 2008
    ..3% of resistants (P=0.021). In conclusion, resistance to CB was associated with DRD2 NcoI-T+ allele, consistent with evidence suggesting that this variant may lead to reduction and instability of DRD2 mRNA or protein...
  40. ncbi request reprint Adiponectin expression in human fetal tissues during mid- and late gestation
    S Corbetta
    Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, Via F Sforza, 35, 20122 Milan, Italy
    J Clin Endocrinol Metab 90:2397-402. 2005
    ..The unexpected pattern of ApN expression in the human fetus may account for the high ApN levels in cord blood and predicts novel roles for ApN during fetal development...
  41. doi request reprint GH response to oral glucose tolerance test: a comparison between patients with acromegaly and other pituitary disorders
    E Verrua
    Department of Medical Sciences, University of Milan, Milan, Italy
    J Clin Endocrinol Metab 96:E83-8. 2011
    ..However, it is uncertain whether the impaired GH inhibition might be related to subtle abnormalities of GH secretion or to functional and/or anatomical hypothalamic-pituitary disconnection due to tumor per se or treatments...
  42. ncbi request reprint G protein mutations in endocrine diseases
    A Lania
    Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, University of Milan, Via F. Sforza 35, 20122 Milan, Italy
    Eur J Endocrinol 145:543-59. 2001
    ....
  43. ncbi request reprint Effect of a topical treatment in organotypic culture of human breast skin after exposure to gamma-rays
    Nicoletta Gagliano
    Department of Human Morphology, Extracellular Matrix Laboratory, University of Milan, Via Fratelli Cervi, 93 20090 Segrate, Milan, Italy
    Eur J Histochem 51:283-90. 2007
    ..TGF-beta1 seems not affected in cream treated samples. HWE may stimulate skin to mount an early defensive response against damage induced by gamma rays...
  44. pmc Prognostic and predictive value of centrally reviewed Ki-67 labeling index in postmenopausal women with endocrine-responsive breast cancer: results from Breast International Group Trial 1-98 comparing adjuvant tamoxifen with letrozole
    Giuseppe Viale
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan, Milan, Italy
    J Clin Oncol 26:5569-75. 2008
    ..To evaluate the prognostic and predictive value of Ki-67 labeling index (LI) in a trial comparing letrozole (Let) with tamoxifen (Tam) as adjuvant therapy in postmenopausal women with early breast cancer...
  45. ncbi request reprint Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur Cytokine Netw 8:271-4. 1997
    ..In contrast, IL-4, IL-13 and IL-10 either did not affect or they amplified MCP-3 induction in EC. EC-produced MCP-3 may be important in the regulation of extravasation of receptor-expressing cells, including NK cells and eosinophils...