P M Mannucci

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Inhibitor development, immune tolerance and prophylaxis in haemophilia A--the need for an evidence-based approach
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital of Milan, Milan, Italy
    Haemophilia 12:429-34. 2006
  2. pmc Genome-wide association studies in myocardial infarction and coronary artery disease
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Universita degli Studi di Milano, Milan, Italy
    J Tehran Heart Cent 5:116-21. 2010
  3. pmc Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes
    Luca A Lotta
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, U O S Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    BMC Med Genomics 5:7. 2012
  4. doi request reprint Advantages and limits of ADAMTS13 testing in the prognostic assessment of thrombotic thrombocytopenic purpura
    Pier Mannuccio Mannucci
    Scientific Direction, IRCCS Cà Granda Foundation Maggiore Hospital, 20122 Milan, Italy
    Presse Med 41:e157-62. 2012
  5. ncbi request reprint Venous thrombosis: the history of knowledge
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy
    Pathophysiol Haemost Thromb 32:209-12. 2002
  6. pmc Evidence-based recommendations on the treatment of von Willebrand disease in Italy
    Pier Mannuccio Mannucci
    Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Dipartimento di Medicina e Specialità Mediche, Università di Milano e IRCCS Fondazione Ospedale Maggiore, Italy
    Blood Transfus 7:117-26. 2009
  7. ncbi request reprint [HIV-related thrombocytopenias]
    P M Mannucci
    Dipartimento di Medicina Interna, Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Universita degli Studi di Milano
    Ann Ital Med Int 15:20-7. 2000
  8. ncbi request reprint The molecular basis of inherited thrombophilia
    P M Manucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milano, Italy
    Vox Sang 78:39-45. 2000
  9. doi request reprint Back to the future: a recent history of haemophilia treatment
    P M Mannucci
    Department of Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan and IRCCS Maggiore Hospital, Milan, Italy
    Haemophilia 14:10-8. 2008
  10. ncbi request reprint Aspects of the clinical management of hereditary thrombophilia: a personal perspective
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Haemostasis 30:11-5. 2000

Collaborators

Detail Information

Publications170 found, 100 shown here

  1. ncbi request reprint Inhibitor development, immune tolerance and prophylaxis in haemophilia A--the need for an evidence-based approach
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital of Milan, Milan, Italy
    Haemophilia 12:429-34. 2006
  2. pmc Genome-wide association studies in myocardial infarction and coronary artery disease
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Universita degli Studi di Milano, Milan, Italy
    J Tehran Heart Cent 5:116-21. 2010
    ..This review article summarizes the progress achieved in the genetic basis of MI and CAD by means of genome-wide association studies and the potential clinical applications of these findings...
  3. pmc Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes
    Luca A Lotta
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, U O S Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    BMC Med Genomics 5:7. 2012
    ....
  4. doi request reprint Advantages and limits of ADAMTS13 testing in the prognostic assessment of thrombotic thrombocytopenic purpura
    Pier Mannuccio Mannucci
    Scientific Direction, IRCCS Cà Granda Foundation Maggiore Hospital, 20122 Milan, Italy
    Presse Med 41:e157-62. 2012
    ..Current knowledge on the diagnostic and prognostic value of ADAMTS13 and anti-ADAMTS13 assays is summarized in this review...
  5. ncbi request reprint Venous thrombosis: the history of knowledge
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy
    Pathophysiol Haemost Thromb 32:209-12. 2002
    ..Raoul was cured as described above in the year 1271 and was still alive and well in 1282. Not only this is the first case of venous thrombosis, the young age of the patients leads us to suspect that Raoul had a thrombophilic condition...
  6. pmc Evidence-based recommendations on the treatment of von Willebrand disease in Italy
    Pier Mannuccio Mannucci
    Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Dipartimento di Medicina e Specialità Mediche, Università di Milano e IRCCS Fondazione Ospedale Maggiore, Italy
    Blood Transfus 7:117-26. 2009
    ..The aim of treatment is to correct the dual defect of haemostasis caused by the abnormal/reduced VWF and the concomitant deficiency of factor VIII (FVIII)...
  7. ncbi request reprint [HIV-related thrombocytopenias]
    P M Mannucci
    Dipartimento di Medicina Interna, Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Universita degli Studi di Milano
    Ann Ital Med Int 15:20-7. 2000
    ..On the whole, thrombocytopenia is generally a relatively mild complication of the human immunodeficiency virus infection and aggressive treatment is often unwarranted...
  8. ncbi request reprint The molecular basis of inherited thrombophilia
    P M Manucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milano, Italy
    Vox Sang 78:39-45. 2000
    ..Other causes of inherited thrombophilia are much rarer, such as dysfibrinogenemia, or not firmly established, such as abnormalities of the fibrinolytic system (plasminogen, histidin-rich glycoprotein) and thrombomodulin...
  9. doi request reprint Back to the future: a recent history of haemophilia treatment
    P M Mannucci
    Department of Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan and IRCCS Maggiore Hospital, Milan, Italy
    Haemophilia 14:10-8. 2008
    ....
  10. ncbi request reprint Aspects of the clinical management of hereditary thrombophilia: a personal perspective
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Haemostasis 30:11-5. 2000
    ..Which treatment strategy to adopt for intermediate-risk patients is more controversial -- prolongation of oral anticoagulant therapy to at least 12 months is suggested...
  11. ncbi request reprint Treatment of von Willebrand disease
    P M Mannucci
    Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 86:149-53. 2001
    ..Concentrates treated with virus inactivation methods should be preferred to cryoprecipitate because they are equally effective and perceived as safer...
  12. ncbi request reprint Changes in health and disease of the metalloprotease that cleaves von Willebrand factor
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico Maggiore Hospital, University of Milan, Italy
    Blood 98:2730-5. 2001
    ..In conclusion, low plasma levels of the vWF cleaving protease are not a specific beacon of TTP because the protease is also low in several physiological and pathologic conditions...
  13. ncbi request reprint Hemophilia: treatment options in the twenty-first century
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Maggiore Hospital, Italy
    J Thromb Haemost 1:1349-55. 2003
    ..Affordable gene transfer will be the ultimate solution for hemophilia in the third world as in the first. Thus it may be confidently predicted that the early new millennium will see an end to this ancient scourge...
  14. ncbi request reprint Treatment of von Willebrand's Disease
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and the Department of Internal Medicine and Dermatology, Istituto di Ricovero e Cura a Carattere Scientifico Maggiore Hospital and the University of Milan, Milan
    N Engl J Med 351:683-94. 2004
  15. ncbi request reprint How I treat patients with von Willebrand disease
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy
    Blood 97:1915-9. 2001
    ..Concentrates treated with virucidal methods should be preferred to cryoprecipitate because they are equally effective and are perceived as safer. (Blood. 2001;97:1915-1919)..
  16. doi request reprint New antiplatelet agents: why they are needed
    Massimo Franchini
    Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Italy
    Eur J Intern Med 20:733-8. 2009
    ....
  17. doi request reprint Mechanism of hemostasis defects and management of bleeding in patients with acute coronary syndromes
    Pier Mannuccio Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, IRCCS Cà Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
    Eur J Intern Med 21:254-9. 2010
    ..In conclusion, evidence-based recommendations for the management of bleeding in patients with ACS are currently lacking, so that prevention through accurate assessment of the individual risk is the most valid strategy...
  18. doi request reprint The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease
    P M Mannucci
    Centro Emofilia e Trombosi A Bianchi Bonomi, Scientific Direction, IRCCS Fondazione Cà Granda Ospedale Maggiore, Universita degli Studi di Milano, Milan, Italy
    J Thromb Haemost 8:2116-21. 2010
    ....
  19. ncbi request reprint Choice of replacement therapy for hemophilia: recombinant products only?
    P M Mannucci
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy
    Hematol J 1:72-6. 2000
    ..However, availability and cost still oblige most physicians to ration recombinant products and prioritize certain patient groups (previously untreated, previously uninfected)...
  20. doi request reprint Severe hemophilia with mild bleeding phenotype: molecular characterization and global coagulation profile
    E Santagostino
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Department of Medicine and Medical Specialties, IRCCS Ca Granda Foundation, Policlinico Maggiore Hospital, Luigi Villa Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 8:737-43. 2010
    ..Such global coagulation tests as thrombin generation assays are tools with which to investigate different coagulation profiles among severe hemophiliacs...
  21. ncbi request reprint Expression studies of missense mutations p.D141Y, p.C275S located in the propeptide of von Willebrand factor in patients with type 3 von Willebrand disease
    L Baronciani
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Foundation IRCCS Maggiore Policlinico Hospital, Mangiagalli, Regina Elena and University of Milan, Milan, Italy
    Haemophilia 14:549-55. 2008
    ..Co-expression of hybrid rVWFs confirmed the recessive inheritance pattern of these missense mutations...
  22. ncbi request reprint Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia
    I Martinelli
    Department of Internal Medicine and Medical Specialties, Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital Policlinico, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 5:98-101. 2007
    ..For prothrombin G20210A, data are scanty and controversial...
  23. ncbi request reprint Congenital afibrinogenemia: mutations leading to premature termination codons in fibrinogen A alpha-chain gene are not associated with the decay of the mutant mRNAs
    R Asselta
    Department of Biology and Genetics for Medical Sciences, University of Milan, Italy
    Blood 98:3685-92. 2001
    ..Moreover, ex vivo analysis at the protein level demonstrated that the presence of each mutation was sufficient to abolish fibrinogen secretion...
  24. ncbi request reprint Prothrombin A19911G polymorphism and the risk of venous thromboembolism
    I Martinelli
    Department of Internal Medicine and Medical Specialties, A Bianchi Bonomi Haemophilia and Thrombosis Center, University of Milan, and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 4:2582-6. 2006
    ..The A > G polymorphism at position 19911 of the prothrombin gene is associated with increased plasma prothrombin levels but its role as a risk factor for venous thromboembolism (VTE) is not established...
  25. ncbi request reprint A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function
    E Biguzzi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milano, Italy
    Thromb Haemost 86:945-8. 2001
    ..Further clinical studies of adequate samples size are necessary to establish whether or not the EPCR insertion predisposes to the development of thrombotic events...
  26. ncbi request reprint Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 86:800-3. 2001
    ..On the basis of these findings we recommend that these women receive anticoagulant prophylaxis at least in the postpartum, that should perhaps be extended to the whole pregnancy in homozygous carriers...
  27. ncbi request reprint Laboratory screening of thrombophilia. Evaluation of the diagnostic efficacy of a global test to detect congenital deficiencies of the protein C anticoagulant pathway
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milan, Italy
    Blood Coagul Fibrinolysis 9:485-9. 1998
    ....
  28. ncbi request reprint Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Epidemiology Unit, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Blood 92:2353-8. 1998
    ..In addition, individuals with factor V Leiden develop less severe thrombotic manifestations, such as superficial vein thrombosis...
  29. ncbi request reprint Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S deficiency, or activated protein C resistance: a multicenter collaborative family study
    P Bucciarelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy
    Arterioscler Thromb Vasc Biol 19:1026-33. 1999
    ..AT deficiency seems to have a higher risk for VTE than the other genetic defects. There is a relation between age and occurrence of thrombosis for both men and women. The latter had the peak of incidence earlier than the former...
  30. ncbi request reprint The JAK2 V617F mutation in patients with cerebral venous thrombosis
    S M Passamonti
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicina and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
    J Thromb Haemost 10:998-1003. 2012
    ..It is currently unclear whether or not cerebral venous thrombosis, such as splanchnic venous thrombosis, can be the first manifestation of an underlying myeloproliferative neoplasm...
  31. doi request reprint Source and purity of factor VIII products as risk factors for inhibitor development in patients with hemophilia A
    M E Mancuso
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
    J Thromb Haemost 10:781-90. 2012
    ..Inhibitor development is influenced by several factors and the type of factor VIII (FVIII) products may play a role...
  32. doi request reprint Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly
    L Pasina
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Intern Med 22:205-10. 2011
    ..Inappropriate prescription is of particular concern among elderly patients, who have often multiple comorbidities and need many drugs...
  33. ncbi request reprint The risk of first venous thromboembolism during pregnancy and puerperium in double heterozygotes for factor V Leiden and prothrombin G20210A
    I Martinelli
    A Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University of Milan and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 6:494-8. 2008
    ..Hence, whether or not these women deserve antithrombotic prophylaxis when pregnant is unknown...
  34. ncbi request reprint The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or both
    I Martinelli
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, University of Milan, Italy
    Br J Haematol 111:1223-9. 2000
    ..Anticoagulant prophylaxis seems to be indicated only when transient risk factors for thrombosis coexist with mutations...
  35. ncbi request reprint Afibrinogenemia: first identification of a splicing mutation in the fibrinogen gamma chain gene leading to a major gamma chain truncation
    R Asselta
    Department of Biology and Genetics for Medical Sciences, University of Milan Institute of Veterinary Physiology and Biochemistry, University of Milan, Italy
    Blood 96:2496-500. 2000
    ....
  36. ncbi request reprint Severe factor V deficiency: exon skipping in the factor V gene causing a partial deletion of the C1 domain
    R Asselta
    Department of Biology and Genetics for Medical Sciences, University of Milan, via Viotti 3 5, 20133 Milan, Italy
    J Thromb Haemost 1:1237-44. 2003
    ..Among rare inherited coagulopathies, FV deficiency is the least characterized from a molecular point of view (only 12 mutations have been reported)...
  37. ncbi request reprint Laboratory investigation of thrombophilia
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Via Pace 9, 20122 Milan, Italy
    Clin Chem 47:1597-606. 2001
    ..Hyperhomocysteinemia can be diagnosed by HPLC methods or by fluorescence polarization immunoassays...
  38. ncbi request reprint Familial dysfunction of protein S
    P M Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milano, Italy
    Thromb Haemost 62:763-6. 1989
    ..We postulate that the defect is due to a dysfunctional protein S present in plasma in normal amounts and with normal proportions of the free and complexed forms of the protein...
  39. doi request reprint Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis
    I Martinelli
    A Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    Eur J Neurol 17:1482-5. 2010
    ..Its role in cerebral sinus-venous thrombosis (CSVT) is not known...
  40. ncbi request reprint Biochemical characterization of a recombinant von Willebrand factor (VWF) with combined type 2B and type 1 defects in the VWF gene in two patients with a type 2A phenotype of von Willebrand disease
    L Baronciani
    Department of Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 5:282-8. 2007
    ..The two brothers were compound heterozygotes (C275R/P1337L), whereas the others members of the family were heterozygous for C275R (a novel mutation in the D1 domain) or P1337L (a type 2B mutation in the A1 domain)...
  41. ncbi request reprint Interaction between the G20210A mutation of the prothrombin gene and oral contraceptive use in deep vein thrombosis
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, and Epidemiology Unit, IRCCS Maggiore Hospital, University of Milan, Italy
    Arterioscler Thromb Vasc Biol 19:700-3. 1999
    ..We conclude that carriers of the prothrombin mutation who use oral contraceptives have a markedly increased risk of deep vein thrombosis, much higher than the risk conferred by either factor alone...
  42. doi request reprint Hepatitis C virus/human immunodeficiency virus coinfection in hemophiliacs: high rates of sustained virologic response to pegylated interferon and ribavirin therapy
    M E Mancuso
    Department of Medicine and Medical Specialities, Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 7:1997-2005. 2009
    ..Nonetheless, in HCV-infected hemophiliacs, who are considered to constitute a difficult-to-treat population, current treatment strategies yielded rates of SVR similar to those obtained in non-hemophiliacs...
  43. ncbi request reprint Optimising local therapy during oral surgery in patients with von Willebrand disease: effective results from a retrospective analysis of 63 cases
    A B Federici
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre and Department of Internal Medicine, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Haemophilia 6:71-7. 2000
    ....
  44. ncbi request reprint Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Italy
    Arterioscler Thromb Vasc Biol 17:755-9. 1997
    ..Homozygosity for the 4G allele, despite its association with impaired fibrinolysis, is compatible with successful aging...
  45. ncbi request reprint Coinheritance of the HR2 haplotype in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (factor V Leiden)
    E M Faioni
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Internal Medicine, IRCCS Maggiore Hospital and University of Milano, Milan, Italy
    Blood 94:3062-6. 1999
    ....
  46. doi request reprint Central nervous system bleeding in patients with rare bleeding disorders
    S M Siboni
    Centro Emofilia e Trombosi A Bianchi Bonomi, Dipartimento di Medicina Interna e Specialita Mediche, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano, Universita degli Studi di Milano, Milano, Italy
    Haemophilia 18:34-8. 2012
    ..Our results indicate that some RBDs require early prophylactic treatment to prevent CNS bleeding. Optimal dosage and frequency of treatment need further evaluation...
  47. ncbi request reprint Factor V Leiden and G20210A prothrombin mutation and the risk of subclavian vein thrombosis in patients with breast cancer and a central venous catheter
    M Mandala
    Division of Medical Oncology, European Institute of Oncology, Milan, Italy
    Ann Oncol 15:590-3. 2004
    ....
  48. ncbi request reprint Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
    M Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Milan, Italy
    Blood 80:2787-96. 1992
    ....
  49. ncbi request reprint Expression studies on a novel type 2B variant of the von Willebrand factor gene (R1308L) characterized by defective collagen binding
    L Baronciani
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 3:2689-94. 2005
    ..The latter finding suggests a more important role than recognized so far for the VWF A1 domain in VWF binding to collagen, which may contribute to the in vivo hemostatic defect associated with type 2B VWD...
  50. ncbi request reprint Quality of life is associated to the orthopaedic status in haemophilic patients with inhibitors
    L Scalone
    Centre of Pharmacoeconomics, Department of Pharmacological Sciences, University of Milan, and Department of Internal Medicine and Dermatology, Mangiagalli Hospital Foundation, Milan, Italy
    Haemophilia 12:154-62. 2006
    ....
  51. ncbi request reprint Anti-beta 2 glycoprotein I antibodies and the risk of myocardial infarction in young premenopausal women
    P L Meroni
    Department of Internal Medicine, University of Milan, Milan, Italy
    J Thromb Haemost 5:2421-8. 2007
    ..This discrepancy is perhaps related to the confounding effect of traditional risk factors. Among them, coronary atherosclerosis appears to be the most important in studies conducted in middle-aged and elderly patients...
  52. ncbi request reprint Autosomal recessive deficiencies of coagulation factors
    F Peyvandi
    The Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milano, Via Pace 9, 20122 Milan, Italy
    Rev Clin Exp Hematol 5:369-88. 2001
    ..This article reviews these disorders, in terms of clinical manifestations and characterization of the molecular defects. The general principles of management are also discussed...
  53. ncbi request reprint Plasma levels of activated protein C in healthy subjects and patients with previous venous thromboembolism: relationships with plasma homocysteine levels
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
    Arterioscler Thromb Vasc Biol 18:1371-5. 1998
    ..This study indicates that APC plasma levels are sensitive markers of activation of the hemostatic system in vivo and that Hcy does not interfere with the activation of PC in vivo...
  54. ncbi request reprint Genetic risk factors for superficial vein thrombosis
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 82:1215-7. 1999
    ..Hence, a laboratory search of these alterations is recommended in patients with SVT, because it allows the identification of patients at high risk of DVT in whom antithrombotic prophylaxis is particularly warranted...
  55. ncbi request reprint Low borderline plasma levels of antithrombin, protein C and protein S are risk factors for venous thromboembolism
    P Bucciarelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Milan
    J Thromb Haemost 10:1783-91. 2012
    ..They are usually defined by laboratory cut-offs (in our setting 81, 70 and 63 IU dL(-1), respectively), which give only a rough idea of the VTE risk associated with plasma levels of these proteins...
  56. ncbi request reprint The international normalized ratio to prioritize patients for liver transplantation: problems and possible solutions
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 6:243-8. 2008
    ....
  57. ncbi request reprint Low levels of heparin-releasable tissue factor pathway inhibitor in young patients with thrombosis
    R A Ariëns
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Ospedale Maggiore IRCCS and University of Milan, Italy
    Thromb Haemost 81:203-7. 1999
    ..However, the causative role of low heparin-releasable TFPI remains uncertain, because co-segregation of the defect with thrombotic symptoms could not be demonstrated in the small number of families studied...
  58. ncbi request reprint Identification of four novel polymorphisms in the Aalpha and gamma fibrinogen genes and analysis of association with plasma levels of the protein
    M Menegatti
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Department of Internal Medicine, University of Milan, Milan, Italy
    Thromb Res 103:299-307. 2001
    ..In the multivariate linear regression analysis, no statistically significant association with plasma fibrinogen levels was found...
  59. ncbi request reprint Guidelines for the diagnosis and management of von Willebrand disease in Italy
    A B Federici
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
    Haemophilia 8:607-21. 2002
    ..Platelet concentrates or desmopressin can be used as adjunctive treatments when poor correction of BT after plasma concentrate treatment is associated with continued bleeding...
  60. ncbi request reprint Treatment of acquired von Willebrand syndrome in patients with monoclonal gammopathy of uncertain significance: comparison of three different therapeutic approaches
    A B Federici
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milano and Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    Blood 92:2707-11. 1998
    ....
  61. ncbi request reprint Efficacy and safety of highly purified, doubly virus-inactivated VWF/FVIII concentrates in inherited von Willebrand's disease: results of an Italian cohort study on 120 patients characterized by bleeding severity score
    A B Federici
    Angelo Bianchi Bonomi Hemophilia Thrombosis Center, Department of Medicine and Medical Specialties, IRCCS Foundation Ospedale Maggiore, Mangiagalli, Regina Elena and Universita degli Studi di Milano, Via Pace 9, Milan, Italy
    Haemophilia 16:101-10. 2010
    ..These results confirm the efficacy and safety of the study concentrates, not only in the management of bleeding and surgery but also in secondary prophylaxis of severe VWD...
  62. ncbi request reprint The hemostatic system through aging and menopause
    P Bucciarelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University of Milan and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Climacteric 12:47-51. 2009
    ..g. diabetes mellitus, arterial hypertension, dyslipidemia, obesity, smoking)...
  63. ncbi request reprint Tissue plasminogen activator antigen is strongly associated with myocardial infarction in young women
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Luigi Villa and Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milano, Milano, Italy
    J Thromb Haemost 3:280-6. 2005
    ..66-25.20), respectively. In conclusion, there is a strong association between non-fatal AMI and increased plasma levels of tPA antigen. This finding is thought to be the expression of a reduced rather than enhanced fibrinolytic activity...
  64. ncbi request reprint Type 2A (IIH) von Willebrand disease is due to mutations that affect von Willebrand factor multimerization
    L Baronciani
    Department of Medicine and Medical Specialties, Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Policlinico Hospital, Mangiagalli, Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 7:1114-22. 2009
    ..Type IIH von Willebrand disease was reported 20 years ago as a novel variant characterized by the loss of the largest multimers in plasma and platelets and absence of the typical triplet structure...
  65. ncbi request reprint Multicenter study of homocysteine measurement--performance characteristics of different methods, influence of standards on interlaboratory agreement of results
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 85:291-5. 2001
    ..Between-lab comparability of results is still a problem. The establishment of an international plasma standard would be of help to harmonize tHcy measurement across laboratories...
  66. ncbi request reprint Transmission of hepatitis A to patients with hemophilia by factor VIII concentrates treated with organic solvent and detergent to inactivate viruses. The Italian Collaborative Group
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Milan, Italy
    Ann Intern Med 120:1-7. 1994
    ..To determine whether an outbreak of hepatitis A virus (HAV) infection that occurred in 52 patients with hemophilia in Italy was acquired through infusion of contaminated factor VIII or through environmental enteric transmission...
  67. ncbi request reprint Occurrence of inhibitors in previously untreated or minimally treated patients with haemophilia A after exposure to a plasma-derived solvent-detergent factor VIII concentrate
    A Gringeri
    Department of Internal Medicine and Dermatology, IRCCS Maggiore Policlinic, Regina Elena, Mangiagalli Hospital Foundation, and Department of Pharmacological Sciences, University of Milan, Italy
    Haemophilia 12:128-32. 2006
    ....
  68. doi request reprint Platelet reactive conformation and multimeric pattern of von Willebrand factor in acquired thrombotic thrombocytopenic purpura during acute disease and remission
    L A Lotta
    UOS Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre and Scientific Direction, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Fondazione Luigi Villa, Universita degli Studi di Milano, Milan, Italy
    J Thromb Haemost 9:1744-51. 2011
    ..Binding of von Willebrand factor (VWF) multimers of ultra-large size to platelets is considered the triggering mechanism of microvascular thrombosis in thrombotic thrombocytopenic purpura (TTP)...
  69. ncbi request reprint In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production
    M Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, I R C C S Maggiore Hospital, Italy
    Thromb Res 62:717-24. 1991
    ..In conclusion, picotamide inhibits the TxA2/PE-dependent platelet responses to agonists by a double mechanism: (i), TxA2/PE antagonism; (ii) inhibition of thromboxane synthase...
  70. ncbi request reprint High thrombin generation measured in the presence of thrombomodulin is associated with an increased risk of recurrent venous thromboembolism
    A Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan
    J Thromb Haemost 6:1327-33. 2008
    ..Because of the large numbers of such putative parameters, the assessment in individual patients is complex. Application of global assays reflecting the pro-/anti-coagulant balance in vivo would be desirable...
  71. ncbi request reprint Von Willebrand factor in high-purity factor VIII complex concentrates: chaperone protein or key to therapies? A meeting report
    A B Federici
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia Thrombosis Center, IRCCS Foundation Maggiore Policlinico Hospital, Mangiagalli, Regina Elena and University of Milan, Milan, Italy
    Haemophilia 14:133-9. 2008
  72. ncbi request reprint International collaborative study for the calibration of a proposed reference preparation for thromboplastin, human recombinant, plain. On behalf of the Subcommittee on Control of Anticoagulation
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 79:439-43. 1998
    ..The assigned ISI (SE of the mean) value is 0.940 (0.0060) and the interlaboratory coefficient of variation 4.7%...
  73. ncbi request reprint Early presence of activated ('exhausted') platelets in malignant tumors (breast adenocarcinoma and malignant melanoma)
    P M Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Italy
    Eur J Cancer Clin Oncol 25:1413-7. 1989
    ..Our data indicate that the presence of exhausted platelets is an early finding in patients with malignant tumors...
  74. ncbi request reprint Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion
    S Duga
    Department of Biology and Genetics for Medical Sciences, the Institute of Veterinary Physiology and Biochemistry, The Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Italy
    Blood 95:1336-41. 2000
    ..These findings demonstrated that missense mutations in the Bbeta fibrinogen gene could cause congenital afibrinogenemia by impairing fibrinogen secretion. (Blood. 2000;95:1336-1341)..
  75. ncbi request reprint Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, University of Milano, Italy
    Circulation 110:566-70. 2004
    ..Risk factors for primary upper-extremity DVT are not well established, and the recurrence rate is unknown...
  76. ncbi request reprint Mutations in coagulation factors in women with unexplained late fetal loss
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico Maggiore Hospital, University of Milan, Italy
    N Engl J Med 343:1015-8. 2000
    ..Whether any of these mutations is associated with an increased risk of late fetal death is not known...
  77. ncbi request reprint Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 87:791-5. 2002
    ..Among thrombophilic abnormalities, the prothrombin mutation was the weakest risk factor. Thrombosis occurred more frequently in puerperium than in pregnancy, whether or not thrombophilia was diagnosed...
  78. ncbi request reprint Identification and three-dimensional structural analysis of nine novel mutations in patients with prothrombin deficiency
    S Akhavan
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, Italy
    Thromb Haemost 84:989-97. 2000
    ..The dysprothrombinemia mutations were inferred to directly affect catalytic function through their location at the active site crevice or exosite 1 within the serine protease domain...
  79. ncbi request reprint Effect of abciximab on prothrombin activation and thrombin generation in patients with acute myocardial infarction also receiving reteplase
    Piera Angelica Merlini
    Division of Cardiology, Ospedale Niguarda, Milan, Italy
    Am J Cardiol 93:195-8. 2004
    ....
  80. ncbi request reprint International sensitivity index calibration of the near-patient testing prothrombin time monitor, ProTime
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and Istituto Ricovero e Cura a Carattere Scientifico Maggiore Hospital, Milano, Italy
    Am J Clin Pathol 119:241-5. 2003
    ..Confirmation of these results in a large multicenter study is warranted...
  81. ncbi request reprint Von Willebrand factor: another janus-faced hemostasis protein
    Massimo Franchini
    Immunohematology and Transfusion Centre, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Italy
    Semin Thromb Hemost 34:663-9. 2008
    ..In addition, high plasma levels of VWF have been associated with an increased risk of atherothrombosis. The current article reviews the literature and provides evidence for the two-faced character that VWF therefore represents...
  82. ncbi request reprint Oral surgery in patients on oral anticoagulant therapy: a randomized comparison of different intensity targets
    R Sacco
    Istituto Stomatologico Italiano, Milan, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:e18-21. 2007
    ..To evaluate whether or not it is possible to perform oral surgery in patients on oral anticoagulant therapy (OAT) without stopping treatment...
  83. ncbi request reprint Comparison of two immunoassays for the complement protein C4b-binding protein in health and disease
    R Coppola
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, Milan, Italy
    Int J Clin Lab Res 25:88-92. 1995
    ..223 +/- 67%). In these patients crossed immunoelectrophoresis showed a pattern different from that of normal individuals, which may explain the lower values found with the Laurell method...
  84. ncbi request reprint Treatment of hemophilia: recombinant factors only? No
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Italy
    J Thromb Haemost 1:216-7. 2003
  85. pmc Hypercoagulability in splenectomized thalassemic patients detected by whole-blood thromboelastometry, but not by thrombin generation in platelet-poor plasma
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Haematologica 94:1520-7. 2009
    ..They might be related to the effects of red blood cell or endothelial cell derangements, increased numbers of platelets as well as abnormal plasma coagulation...
  86. ncbi request reprint A prospective randomized trial of high and standard dosages of recombinant factor VIIa for treatment of hemarthroses in hemophiliacs with inhibitors
    E Santagostino
    Department of Internal Medicine and Dermatology, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 4:367-71. 2006
    ....
  87. ncbi request reprint Activated partial thromboplastin time (APTT). New indications for an old test?
    A Tripodi
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 4:750-1. 2006
  88. ncbi request reprint Abnormal secretion and function of recombinant human factor VII as the result of modification to a calcium binding site caused by a 15-base pair insertion in the F7 gene
    F Peyvandi
    Hematology Section, Department of Medicine, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA
    Blood 97:960-5. 2001
    ..These results demonstrate that a combination of secretion and functional defects is the mechanism whereby this insertion causes VII deficiency...
  89. ncbi request reprint Genetic diagnosis of haemophilia and other inherited bleeding disorders
    F Peyvandi
    Department of Medicine and Medical Specialities, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Luigi Villa Foundation, University of Milan, Milan, Italy
    Haemophilia 12:82-9. 2006
    ..This article reviews the genetic diagnosis of haemophilia, genetics and inhibitor development, genetics of von Willebrand's disease and of rare bleeding disorders...
  90. ncbi request reprint Rare bleeding disorders
    F Peyvandi
    Department of Medicine and Medical Specialities, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, Milan, Italy
    Haemophilia 12:137-42. 2006
    ..This article reviews the genetic basis of RBDs, problems and complications of treatment, problems in the preparation of suitable guidelines for treatment and the future perspectives of the International Registry on RBDs...
  91. ncbi request reprint Immune tolerance induction with a high purity von Willebrand factor/VIII complex concentrate in haemophilia A patients with inhibitors at high risk of a poor response
    A Gringeri
    A Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Medicine and Medical Specialties, University of Milan and IRCCS Maggiore Hospital, Milan, Italy
    Haemophilia 13:373-9. 2007
    ..These findings suggest that high purity VWF/FVIII complex concentrates are effective in ITI, even in patients at high risk of failure...
  92. ncbi request reprint Laboratory control of oral anticoagulant treatment by the INR system in patients with the antiphospholipid syndrome and lupus anticoagulant. Results of a collaborative study involving nine commercial thromboplastins
    A Tripodi
    The Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Br J Haematol 115:672-8. 2001
    ..New thromboplastins, especially those made of relipidated tissue factor, should be checked for their responsiveness to LA before they are used to monitor oral anticoagulant treatment in patients with APS...
  93. ncbi request reprint Abnormal hemostasis tests and bleeding in chronic liver disease: are they related? No
    P M Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 4:721-3. 2006
  94. ncbi request reprint Standardization of the APC resistance test. Effects of normalization of results by means of pooled normal plasma
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 79:564-6. 1998
    ..APC ratios for PNP A by all methods were significantly lower than those for PNP B. Thus, the presence of mutant FV in a proportion as low as 2.5% may reduce the APC ratio of the PNP...
  95. ncbi request reprint Consistency of ADAMTS-13 activity assays: a moderately optimistic view
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    J Thromb Haemost 1:1880-1. 2003
  96. ncbi request reprint Desmopressin (DDAVP) and factor VIII: the tale as viewed from Milan (and Malmö)
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and Department of Internal Medicine, Milan, Italy
    J Thromb Haemost 1:622-4. 2003
  97. ncbi request reprint Optimizing therapy with factor VIII/von Willebrand factor concentrates in von Willebrand disease
    A B Federici
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Haemophilia 4:7-10. 1998
    ....
  98. ncbi request reprint High prevalence of hyperchomocysteinemia in patients with inflammatory bowel disease: a pathogenic link with thromboembolic complications?
    M Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, and Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
    Thromb Haemost 80:542-5. 1998
    ..Since they may have impaired absorption of vitamins that regulate the metabolism of homocysteine, we tested the hypothesis that they have hyperhomocysteinemia, an established risk factor for arterial and venous thrombosis...
  99. doi request reprint Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, IRCCS Cà Granda Ospedale Maggiore Policlinico Foundation and Università degli Studi di Milano, Via Pace 9, 20122 Milan, Italy
    J Thromb Thrombolysis 31:165-72. 2011
    ..These findings might explain the relatively high risk of atherothrombosis and VTE described in these patients...
  100. ncbi request reprint Interference of factor V Leiden on protein S activity: evaluation of a new prothrombin time-based assay
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Blood Coagul Fibrinolysis 18:543-6. 2007
    ..Protein S activity measurement for FVL-positive patients should be performed on diluted plasma and the results interpreted on the basis of the cut-off value specifically determined for diluted plasmas...
  101. ncbi request reprint Management of inherited von Willebrand disease in 2007
    Augusto B Federici
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Medicine and Medical Specialities, IRCCS Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    Ann Med 39:346-58. 2007
    ..In type 3 and in severe forms of types 1 and 2 VWD, DDAVP is not effective and plasma virally inactivated VWF concentrates should be used in bleedings, surgery, and secondary long-term prophylaxis...