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Species | R ManfrediSummaryAffiliation: University of Bologna Country: Italy Publications
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Publications
Limited access to hospitalization in an Italian infectious disease wardR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Med Mal Infect 34:144-7. 2004....
Prospective, open-label comparative study of liver toxicity in an unselected population of HIV-infected patients treated for the first time with efavirenz or nevirapineRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
HIV Clin Trials 6:302-11. 2005....
Disseminated, lethal prostate cancer during human immunodeficiency virus infection presenting with non-specific features. Open questions for urologists, oncologists, and infectious disease specialistsRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Cancer Detect Prev 30:20-3. 2006....
[The role of a novel antiretroviral class (fusion inhibitors) in the treatment of advanced HIV infection. Preliminary experience with enfuvirtide]Roberto Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Universita degli Studi di Bologna Alma Mater Studiorum, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 96:124-30. 2005..The management of the very frequent site injection reactions represents an adjunctive problem in the treatment of these multi-problematic patients...
[Screening of adult patients with fever of unknown origin. A prospective study on the role of primary cytomegalovirus infection]Roberto Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Divisione di Malattie Infettive, Università di Bologna Alma Mater Studiorum, Azienda Ospedaliera Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 97:79-84. 2006..5%) were found to have a primary Cytomegalovirus infection...
Primary cytomegalovirus infection in otherwise healthy adults with Fever of unknown origin: a 3-year prospective surveyR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, 40138 Bologna, Italy
Infection 34:87-90. 2006..Primary cytomegalovirus disease is probably still underestimated or missed in common clinical practice, and further prevalence studies should be performed, in particular in the setting of fever of under-determined origin (FUO) in adults...
Prospective comparison of first-line nelfinavir therapy versus nelfinavir introduction in rescue antiretroviral regimensRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
AIDS Patient Care STDS 17:105-14. 2003....
Multiple, severe lung infiltrates due to Mycobacterium avium-intracellulare in a patient with decompensated liver cirrhosis: Spontaneous resolution after a two-year follow-upRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Scand J Infect Dis 38:469-73. 2006..Moreover, this extraordinary episode resolved spontaneously within the 2-y follow-up, as documented by bronchoalveolar lavage, culture, high-resolution CT scans, and scintigraphic examination...
[HIV disease, antiretroviral treatment and the liver--emerging problems]Roberto Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universita degli Studi di Bologna Alma Mater Studiorum, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 94:149-53. 2003....
True gynecomastia in congenitally HIV-infected children treated with antiretroviral agentsR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Chemother 16:303-5. 2004..We report the first two cases of true gynecomastia observed in prepubertal congenitally-infected boys, and clinical, antiretroviral, metabolic, hormonal, virological, and immunological aspects...
Dual Candida albicans and Cryptococcus neoformans fungaemia in an AIDS presenter: a unique disease association in the highly active antiretroviral therapy (HAART) eraRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Med Microbiol 51:1135-7. 2002....
HIV disease and advanced age: an increasing therapeutic challengeRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Drugs Aging 19:647-69. 2002..Antiretroviral drug dosage adjustment to take into account underlying pathological conditions or other pharmacological treatments is another emerging issue...
Bladder carcinoma and HIV infection during the highly active antiretroviral therapy era: A rare, but intriguing association. Two case reports and literature reviewRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Scand J Infect Dis 38:566-70. 2006..No relationship was found with the very favourable underlying HIV-related virological and immunological status, and the present 8-12-month follow-up did not show disease relapses...
Gabexate mesilate and/or octreotide in human immunodeficiency virus-associated pancreatic abnormalitiesR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Italy
Aliment Pharmacol Ther 16:1791-4. 2002....
A novel antiretroviral class (fusion inhibitors) in the management of HIV infection. Present features and future perspectives of enfuvirtide (T-20)Roberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Malpighi Hospital, Bologna, Italy
Curr Med Chem 13:2369-84. 2006....
Role of Mycobacterium xenopi disease in patients with HIV infection at the time of highly active antiretroviral therapy (HAART). Comparison with the pre-Haart periodRoberto Manfredi
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Tuberculosis (Edinb) 83:319-28. 2003....
Multiple opportunistic AIDS-associated disorders strictly related to immunodeficiency levels, in a girl with congenital HIV infectionRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Int J STD AIDS 14:638-9. 2003....
[Limitation of access to an infectious disease ward due to lack of compatible hospital room. A four-year survey, and relevant observations]Roberto Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università Alma Mater Studiorum, Ospedale Policlinico S Orsola, Bologna
Recenti Prog Med 95:463-6. 2004..This occurrence happened in nearly 25% of patients trasferred from our Hospital from the year 2000...
Epidemiological, clinical and therapeutic features of AIDS-related Mycobacterium kansasii infection during the HIV pandemic: an 11-year follow-up studyR Manfredi
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna, Alma Mater Studiorum, Bologna, Italy
HIV Med 5:431-6. 2004..Optimal diagnosis and timely treatment of atypical mycobacteriosis, and especially Mycobacterium kansasii disease, remain a serious challenge for clinicians engaged in the management of the immunocompromised host...
Severe pneumococcal meningitis heralding a deep hypogammaglobulinaemia related to common variable immunodeficiency, at the age of 27 yearsRoberto Manfredi
Department of Clinical and Experimental Medicine, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Scand J Infect Dis 36:756-8. 2004..Clinicians should maintain an elevated suspicion for congenital immunodeficiency, especially when observing adult patients with a negligible prior history...
A decade surveillance study of Mycobacterium xenopi disease and antimicrobial susceptibility levels in a reference teaching hospital of northern Italy: HIV-associated versus non-HIV-associated infectionRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases
HIV Clin Trials 5:206-15. 2004....
Severe staphylococcal knee arthritis responding favourably to linezolid, after glycopeptide-rifampicin failure: a case report and literature reviewRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Malpighi Hospital, Bologna, Italy
Scand J Infect Dis 37:513-7. 2005..From a clinical viewpoint, the introduction of a 2-week i.v. linezolid followed by 1 further week of oral linezolid led to complete clinical and microbiological cure, and an unexpected functional success...
Chron's disease, rare association with selective IgA immunodeficiency, and development of life-threatening bacterial infectionsRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Scand J Infect Dis 36:523-4. 2004..This unexpected association of a chronic bowel inflammatory syndrome with prominent IgA abnormalities and severe bacterial infection deserves careful attention by physicians faced with young patients with Chron's disease...
HIV infection and advanced age emerging epidemiological, clinical, and management issuesRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, Azienda Ospedaliera di Bologna, S Orsola Hospital, Policlinico S Orsola Malpighi, Bologna, Italy
Ageing Res Rev 3:31-54. 2004..Moreover, epidemiological figures need an increased focus on older age, while clinical trials specifically targeting on the elderly population are mandatory to have reliable data on all aspects of HAART administration in advanced age...
Changing epidemiology of hepatitis A in the Bologna metropolitan area, northern Italy: importance of counselling and prophylactic measures for the male homo/bisexual populationR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Clin Microbiol Infect 11:845-8. 2005..0032). There is a need to re-emphasise targeted educational programmes and anti-HAV vaccination for at-risk subjects...
Efavirenz versus nevirapine in current clinical practice: a prospective, open-label observational studyRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Acquir Immune Defic Syndr 35:492-502. 2004....
Advanced acute myelogenous leukaemia (AML) during HAART-treated HIV disease, manifesting initially as a thyroid massRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Malpighi General Hospital, Bologna, Italy
Scand J Infect Dis 37:781-3. 2005..A such favourable clinical response to acute, advanced myelogenous leukaemia with an insidious recognition is considered infrequent, especially in the setting of HIV disease...
A case-control study of HIV-associated pancreatic abnormalities during HAART era. Focus on emerging risk factors and specific managementRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Eur J Med Res 9:537-44. 2004..The epidemiological and clinical features of HIV-associated pancreatic abnormalities are expected to change after HAART introduction...
High-risk dysmetabolism disorders associated with HAART-treated HIV disease, and reimbursement of lipid-lowering drugs, in a clinical and a socio-economic perspectiveRoberto Manfredi
Department of Clinical and Experimetal Medicine, Division of Infectious Diseases, University of Bologna, Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
AIDS Rev 7:155-60. 2005....
A re-emerging class of antimicrobial agents: streptogramins (quinupristin/dalfopristin) in the management of multiresistant gram-positive nosocomial cocci in hospital settingRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Mini Rev Med Chem 5:1075-81. 2005....
AIDS-associated Cryptococcus infection before and after the highly active antiretroviral therapy era: emerging management problemsRoberto Manfredi
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Int J Antimicrob Agents 22:449-52. 2003..Clinical suspicion for HIV-associated cryptococcosis should be maintained in immunocompromised subjects. The introduction of HAART has led to significant clinical and laboratory changes of HIV-related cryptococcosis...
Severe Candida albicans panophthalmitis treated with all available and potentially effective antifungal drugs: fluconazole, liposomal amphotericin B, caspofungin, and voriconazoleRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Malpighi Hospital, Bologna, Italy
Scand J Infect Dis 38:950-1. 2006....
A prospective comparison of the two main indications of efavirenz in 2001 highly active antiretroviral therapy (HAART) regimens: first-line versus salvage useRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
J Antimicrob Chemother 49:723-9. 2002..To determine the efficacy of efavirenz introduction in first-line HAART compared with salvage multidrug regimens...
The use of efavirenz as a part of late rescue antiretroviral treatmentR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
HIV Clin Trials 2:413-20. 2001..Because rescue antiretroviral strategies are increasingly needed, patients' response to a late salvage treatment including efavirenz plus a novel protease inhibitor (PI), with or without at least one novel nucleoside analogue, was assessed...
Dual nucleoside analogue treatment in the era of highly active antiretroviral therapy (HAART): a single-centre cross-sectional surveyR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
J Antimicrob Chemother 48:299-302. 2001....
[Economic burden and clinical course of HIV infection and AIDS today: how the variation of natural history, available treatments, and strictly related costs play a role in needs of health care]R Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università Alma Mater, Azienda Ospedaliera Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 92:648-54. 2001....
A new syndrome of long-term idiopathic, severe CD4+ lymphocytopenia: isolated paraparesis and conjunctival ischemic microangiopathyR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Biol Regul Homeost Agents 18:33-7. 2004....
Lack of change in the distribution of AIDS-defining opportunistic diseases and the related degree of immunodeficiency during the periods before and after the introduction of highly active antiretroviral therapyR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
Eur J Clin Microbiol Infect Dis 20:410-3. 2001..Even in recent years, the large majority of patients newly diagnosed with AIDS have not been able to take advantage of HAART prior to diagnosis of their disease...
Limits of deep salvage antiretroviral therapy with nelfinavir plus either efavirenz or nevirapine, in highly pre-treated patients with HIV diseaseR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, I 40138, Bologna, Italy
Int J Antimicrob Agents 17:511-6. 2001..However, the concurrent change of nucleoside analogues significantly improves treatment outcome...
Enterobacter spp. infections complicating the course of HIV diseaseR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Chemother 13:195-201. 2001..Despite the unpredictable antibiotic susceptibility profile of these organisms, HIV-related Enterobacter spp. disease may be properly managed through rapid identification and timely and appropriate antimicrobial treatment...
Gynecomastia associated with highly active antiretroviral therapyR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
Ann Pharmacother 35:438-9. 2001..To report four cases of HIV-associated gynecomastia diagnosed during treatment with nucleoside analogs with or without protease inhibitors...
Carpal tunnel syndrome in HIV-infected patients treated with highly active antiretroviral therapy: other case reportsR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
Rheumatol Int 21:81-3. 2001..In our patients, carpal tunnel syndrome occurred in apparent absence of all presumed risk factors of this disease and metabolic abnormalities potentially related to HIV protease inhibitor administration...
Epidemiology and microbiology of cellulitis and bacterial soft tissue infection during HIV disease: a 10-year surveyRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
J Cutan Pathol 29:168-72. 2002..Cellulitis and soft tissue infection are underestimated complications of HIV disease...
Long-term maintenance antiretroviral therapy with saquinavir hard gel, after voluntary abandonment of successful induction HAARTR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, Italy
J Chemother 14:185-8. 2002....
Emergence of amphotericin B-resistant Cryptococcus laurentii meningoencephalitis shortly after treatment for Cryptococcus neoformans meningitis in a patient with AIDSRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
AIDS Patient Care STDS 20:227-32. 2006..All epidemiologic, diagnostic, clinical, and therapeutic implications are discussed on the basis of the evolving characteristics of opportunism in the era of highly active antiretroviral therapy (HAART)...
American cutaneous leishmaniasis as a rare imported disease in Europe: a case report favourably treated with antimonial derivativesR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Malpighi General Hospital, Italy
Eur J Epidemiol 17:793-5. 2001....
[Sexually transmitted diseases (STD) and their relationship with sexual behaviour and condom use, in a cohort of teenagers referring to a STD centre. A nine-year, prospective study]R Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universit degli Studi di Bologna, Azienda Ospedaliera di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
Infez Med 9:147-53. 2001..Besides their diagnostic and therapeutic role, STD centres are able to carry out permanent monitoring of STD, as a starting point to plan adequate information campaigns and specific prevention strategies...
[HIV infection and AIDS in advanced age. Epidemiological and clinical issues, and therapeutic and management problems]R Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universita degli Studi Alma Mater, Policlinico S.Orsola-Malpighi, Bologna, Italy
Infez Med 12:152-73. 2004....
Human immunodeficiency virus and hepatitis C virus coinfection: epidemiology, natural history, therapeutic options and clinical managementG Verucchi
Dept of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, via G Massarenti 11, I 40138, Bologna, Italy
Infection 32:33-46. 2004..Available data show that the sustained virological response rates in coinfected persons treated with standard IFN plus ribavirin range from 18-40%, and several studies with pegylated IFN plus ribavirin are ongoing...
HIV disease among immigrants coming to Italy from outside of the European Union: a case-control study of epidemiological and clinical featuresR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S. Orsola Hospital, Italy
Epidemiol Infect 127:527-33. 2001..0001), and the shorter mean duration of antiretroviral treatment (11.1 +/- 2.2 months of immigrants vs. 16.2 +/- 6.7 months of controls; P < 0.0001)...
[Pathogenic role of Acinetobacter spp during HIV infection]R Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universit degli Studi di Bologna, Azienda Ospedaliera di Bologna, Policlinico S. Orsola Malpighi, Bologna
Infez Med 9:43-51. 2001..Notwithstanding the high drug resistance profile of the majority of isolated organisms, a timely diagnosis and a treatment based on in vitro assays, contribute to avoid recurrences and potentially life-threatening complications...
Cardiovascular risk factors and ultrasound evaluation of carotid atherosclerosis in patients with HIV-1 infectionL Calza
Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Int J STD AIDS 20:683-9. 2009....
Another emerging event occurring during HIV infection treated with any antiretroviral therapy: frequency and role of gynecomastiaR Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, , Azienda Ospedaliera di Bologna, Policlinico S Orsola-Malpighi, Bologna, Italy
Infez Med 12:51-9. 2004..The frequent association with metabolic abnormalities suggests some common ethiologic pathway with other HAART-related disturbances...
The incidence of cytomegalovirus (CMV) antigenemia and CMV disease is reduced by highly active antiretroviral therapyS Varani
Department of Clinical and Experimental Medicine, University of Bologna, Italy
Eur J Epidemiol 16:433-7. 2000..001, t test)...
Efficacy and tolerability of a fosamprenavir-ritonavir-based versus a lopinavir-ritonavir-based antiretroviral treatment in 82 therapy-naïve patients with HIV-1 infectionL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Hospital, Bologna, Italy
Int J STD AIDS 19:541-4. 2008..5% vs. 25.6% and 69.8% vs. 43.6%, respectively; P < 0.01). In subjects with virological failure, no viral protease resistance mutations were detected by genotype analysis...
[Hyperlactacidemia during antiretroviral therapy: frequency and clinical-therapeutic correlations]R Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universita degli Studi di Bologna, Alma Mater Studiorum, Policlinico S. Orsola, Bologna, Italy
Infez Med 14:33-6. 2006..Our case-control study on an extensive, single centre population treated for HIV infection provides novel insights on these emerging issues, reported and discussed on the basis of the most recently published findings...
Rosuvastatin for the treatment of hyperlipidaemia in HIV-infected patients receiving protease inhibitors: a pilot studyLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola Hospital, Bologna, Italy
AIDS 19:1103-5. 2005..01). In our small pilot study, rosuvastatin was found to be effective for the treatment of PI-associated hyperlipidaemia, in association with a favourable tolerability profile, without significant clinical or laboratory adverse events...
Clinical and microbiological survey of Serratia marcescens infection during HIV diseaseR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
Eur J Clin Microbiol Infect Dis 19:248-53. 2000..organisms. In fact, a rapid diagnosis and an adequate and timely treatment can avoid disease relapses and mortality...
Role of gancyclovir and HAART administration in the treatment of a rare complication of HIV disease: cytomegalovirus-associated Guillain-Barré syndromeL Calza
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Chemother 13:575-7. 2001....
[HIV genotypic mutation selectively induced by the protease inhibitor nelfinavir at codon 30. Case series and consequences for antiretroviral management]Roberto Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, , Azienda Ospedaliera di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
Infez Med 10:151-6. 2002....
First-line efavirenz versus lopinavir-ritonavir-based highly active antiretroviral therapy for naive patientsRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna 'Alma Mater Studiorum, S. Orsola Hospital, Bologna, Italy
AIDS 18:2331-3. 2004..Randomized studies comparing these two recommended first-line treatments are warranted, particularly from a pharmacoeconomic viewpoint...
Frequency, epidemiology, risk factors, clinical and bacteriological features of enterococcal disease in patients with HIV infection in a decade surveyR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, Ospedale Policlinico S. Orsola-Malpighi
New Microbiol 25:179-86. 2002..1% of lethal cases among our septic patients)...
Disseminated histoplasmosis with atypical cutaneous lesions in an Italian HIV-infected patient: another autochtonous caseL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
HIV Med 4:145-8. 2003..Our patient represents the fifth autochtonous case of AIDS-associated histoplasmosis described in Italy...
Voriconazole proves effective in long-term treatment of a cerebral cryptococcoma in a chronic nephropathic HIV-negative patient, after fluconazole failureS Sabbatani
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S. Orsola Hospital, Bologna, Italy
Mycopathologia 158:165-71. 2004..A cerebral cryptococcoma in a chronic nephropathic HIV-negative subject with homocystinuria, completely cured with neurosurgery and voriconazole after fluconazole failure, is described...
An active microbiological surveillance project at an Italian teaching hospital: microbial isolates, recent epidemiological trends, major clinical concerns, and antimicrobial susceptibility rates during a four-year periodR Manfredi
Divisione di Malattie Infettive, Alma Mater Studiorum Universita degli Studi di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
Infez Med 17:219-27. 2009....
Associated actinomycosis and rhinopharyngeal adenocarcinoma during HIV infection: diagnostic and therapeutic issuesSergio Sabbatani
Department of Infectious Diseases, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Infez Med 16:164-72. 2008....
A puzzling microbiological and clinical discrepancy in the management of acute, severe skin-soft tissue and joint staphylococcal infection. In vitro antimicrobial susceptibility to glycopeptides, versus in vivo clinical efficacy of linezolid aloneRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S. Orsola-Malpighi Hospital, Bologna, Italy
Infez Med 14:157-64. 2006..When managing severe multiresistant gram-positive infections, in vitro activity should be carefully evaluated against expected drug penetration rates into the relevant infectious tissues...
Nevirapine versus efavirenz in 742 patients: no link of liver toxicity with female sex, and a baseline CD4 cell count greater than 250 cells/microlRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy
AIDS 20:2233-6. 2006....
Statins and fibrates for the treatment of hyperlipidaemia in HIV-infected patients receiving HAARTLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna, S. Orsola Hospital, Italy
AIDS 17:851-9. 2003..CONCLUSIONS: All administered statins and fibrates revealed a similar, significant efficacy in the treatment of diet-resistant hyperlipidaemia, and showed a favourable tolerability profile...
[Problems in the management of HIV infection in clinical practice. Patients still on dual therapy 8 years after the introduction of HAART]Roberto Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale,
Recenti Prog Med 94:506-7. 2003..Three representative case reports are described, and their implications discussed on the ground of current guidelines of antiretroviral therapy and common clinical practice...
Linezolid in the treatment of severe central nervous system infections resistant to recommended antimicrobial compoundsSergio Sabbatani
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S. Orsola Hospital, Bologna, Italy
Infez Med 13:112-9. 2005..Three representative case reports (two brain abscesses and one post-surgical meningitis) are presented and discussed in light of the current literature: in all these cases, salvage linezolid treatment proved resolutory...
[Nocardiosis as the first opportunistic disease in a patient with missed HIV infection. Pathomorphism of presentation, clinical course, and evolution]Roberto Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, , Policlinico S. Orsola-Malpighi, Bologna
Recenti Prog Med 97:262-5. 2006....
Reversal of major genotypic tipranavir mutations under long-term treatment with tipranavir/ritonavir itself with very limited optimized background, during deep salvage antiretroviral therapySergio Sabbatani
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Curr HIV Res 7:311-3. 2009....
[Reduction of antibiotic resistance of Enterococcus faecalis in infections of the genitourinary tract]Roberto Manfredi
Sezione di Malattie Infettive e Sezione di Microbiologia, Dipartimento di Medicina Clinica e Sperimentale, , Azienda Ospedaliera, Policlinico S. Orsola-Malpighi, Bologna
Recenti Prog Med 93:681-2. 2002..As a result, penicillin , ampicillin, nitrofurantoin and piperacillin may still represent first-line agents in our area when community-acquired urinary tract enterococcal infections is of concern, pending in vitro susceptibility studies...
Prevalence of diabetes mellitus, hyperinsulinaemia and metabolic syndrome among 755 adult patients with HIV-1 infectionL Calza
Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, S Orsola Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Int J STD AIDS 22:43-5. 2011..5% and 9.1%, respectively. A longer exposure to antiretroviral therapy and a diagnosis of lipodystrophy syndrome were significantly associated with both metabolic disturbances...
Diffuse skin spread of HIV-associated visceral leishmaniasis: cumbersome diagnostic and therapeutic issuesR Manfredi
Division of Infectious Diseases, Department of Internal Medicine, Aging and Nephrologic Diseases, S Orsola Malpighi Hospital, Bologna, Italy
G Ital Dermatol Venereol 143:339-46. 2008..v. pentamidine isethionate together with oral paromomycin led to a slow, but complete cure of both visceral leishmaniasis and its related skin dissemination, in absence of adverse events and long-term disease relapses...
[The health professional in the dental/oral field and exposure to risk of infection: epidemiology and prevention]R Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione Malattie Infettive, Ama Mater Studiorum Università degli Studi di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
G Ital Med Lav Ergon 29:11-20. 2007..Epidemiological issues and specific risk factors are treated systematically, together with all available, recommended chemoprophylactic and immunological prophylactic strategies...
Listeria monocytogenes meningitis and multiple brain abscesses in an immunocompetent host. Favorable response to combination linezolid-meropenem treatmentR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater StudiorumUniversity of Bologna, S. Orsola Hospital, Bologna, Italy
J Chemother 18:331-3. 2006
A very particular case of long-term non-progressor: nineteen consecutive years of follow-up in the absence of any detectable HIV-1 viraemiaR Manfredi
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna Alma Mater Studiorum, S Orsola Malpighi Hospital, Bologna, Italy
Int J STD AIDS 19:784-5. 2008....
Abacavir-induced reaction with fever and severe skin rash in a patient tested human leukocyte antigen-B*5701 negativeL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Int J STD AIDS 20:276-7. 2009..Similar reports suggest that not all severe abacavir-induced adverse events occur as a result of classic hypersensitivity reactions, and can present also in HLA-B*5701-negative patients...
Community-acquired Pseudomonas aeruginosa sacro-iliitis in a previously healthy patientL Calza
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Med Microbiol 51:620-2. 2002..The first case of Pseudomonas aeruginosa sacro-iliitis is described, which occurred in a previously healthy young man, without history of prior traumatic events, hospitalisation or chronic underlying disease...
Pentamidine isethionate as treatment and secondary prophylaxis for disseminated cutaneous leishmaniasis during HIV infection: case reportL Calza
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Chemother 13:653-7. 2001....
Merkel cell carcinoma in a human immunodeficiency virus-infected patientL Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, 40138 Bologna, Italy
Br J Dermatol 146:895-8. 2002..A case of this cutaneous malignancy, characterized by a short-term local recurrence and systemic fatal spread in spite of surgical treatment, radiotherapy and chemotherapy, is described in a patient with advanced HIV infection...
Stenotrophomonas (Xanthomonas) maltophilia as an emerging opportunistic pathogen in association with HIV infection: a 10-year surveillance studyL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna, S Orsola Hospital, via G Massarenti 11, I 40138 Bologna, Italy
Infection 31:155-61. 2003..At present very limited information is available concerning its clinical significance in the setting of HIV infection...
Osteonecrosis and highly active antiretroviral therapy during HIV infection: report of a series and literature reviewL Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
AIDS Patient Care STDS 15:385-9. 2001..Five cases of osteonecrosis were observed among over 1300 patients with HIV disease. According to our experience, novel antiretroviral regimens do not represent a constant risk factor for avascular necrosis of bone during HIV infection...
[Anthrax]L Calza
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università Alma Mater, Policlinico S Orsola, Bologna
Recenti Prog Med 92:717-26. 2001..Today, after the new events in the United States, at least 17 nations are believed to have offensive biological weapon programs, and this old bacterial infection became a modern menace to world safety...
Transient reversal of HIV-associated motor neuron disease following the introduction of highly active antiretroviral therapyL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Chemother 16:98-101. 2004..A case of MND in a male HIV-infected patient with significant but transient reversal of neurological symptoms after the use of protease inhibitor-containing antiretroviral regimen is described...
Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrateR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, Bologna, Italy
J Infect 42:181-8. 2001..Specific guidelines for the management of disorders of lipid metabolism in HIV-infected patients are needed...
Iliac osteomyelitis and gluteal muscle abscess caused by Streptococcus intermediusL Calza
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Med Microbiol 50:480-2. 2001....
[Epidemics of bovine spongiform encephalopathy and new variant of Creutzfeldt-Jakob disease in humans. Most recent findings on prion disease]L Calza
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universita degli Studi di Bologna, Policlinico S Orsola, Bologna
Recenti Prog Med 92:140-9. 2001..New epidemiological, clinical, histopathological and experimental data on prion diseases are reviewed, focusing our attention on the possible transmission of prion proteins from animals to humans...
Switch of protease inhibitor-containing HAART in routine clinical practice: a four-year prospective observational studyR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
Int J STD AIDS 12:84-8. 2001....
Development of acute psychotic disorders and HIV-1 infectionD De Ronchi
Institute of Psychiatry, Medical School, University of Bologna, Italy
Int J Psychiatry Med 30:173-83. 2000....
Doxycycline and chloroquine as treatment for chronic Q fever endocarditisL Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
J Infect 45:127-9. 2002..A case of chronic Q fever endocarditis is described in a patient with biological prosthetic aortic valve and aortic homograft, successfully treated with doxycycline and chloroquine for 2 years...
Need to evaluate the cost effectiveness of early diagnosis and treatment of osteopenia and osteoporosis in the setting of HIV and highly active antiretroviral therapyRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy
AIDS Patient Care STDS 20:665-7. 2006
[Therapeutic perspectives of linezolid in the management of infections due to multiresistant Gram-positive pathogens]Roberto Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Alma Mater Studiorum Universita di Bologna, Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 98:143-54. 2007....
Hodgkin's disease in the setting of human immunodeficiency virus infectionLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Hospital, Bologna, Italy
Scand J Infect Dis 35:136-41. 2003..In this report cases of Hodgkin's disease are described among over 1,000 HIV-infected patients referring to a tertiary care centre during a 6 y study period...
Clinical ritonavir and lopinavir hypersensitivity confirmed by a specific in vitro cellular allergen stimulation testRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Curr HIV Res 5:440-2. 2007....
Clozapine-related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatmentRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Pharmacoepidemiol Drug Saf 16:1285-9. 2007....
Prolonged statin administration does not act on the cell-mediated immunity of HIV-infected dyslipidemic patients treated with a steady and effective highly active antiretroviral therapy. A two-year prospective study of statin versus fibrate administrationRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Biol Regul Homeost Agents 20:1-9. 2006....
HIV infection and the pancreas: risk factors and potential management guidelinesRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Int J STD AIDS 19:99-105. 2008..single (gabexate mesilate or ocreotide) therapy. Reduced disease recurrences and a better tolerability of antiretroviral regimens, were also noticed...
Associated thyreoiditis, myasthenia gravis, thymectomy, Chron's disease, and erythema nodosum: pathogenetic and clinical correlations, immune system involvement, and systemic infectious complicationsRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Rheumatol Int 28:1173-5. 2008....
