G Mancia

Summary

Affiliation: University of Milano-Bicocca
Country: Italy

Publications

  1. ncbi request reprint Metabolic syndrome in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study: daily life blood pressure, cardiac damage, and prognosis
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Milan, Italy
    Hypertension 49:40-7. 2007
  2. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by r
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Doublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:E1-40. 2007
  3. ncbi request reprint The autonomic nervous system and hypertension
    Giuseppe Mancia
    From the IRCCS Istituto Auxologico Italiano, Milano, Italy G M Clinica Medica, Dipartimento di Scienze della Salute, Universita Milano Bicocca, Monza Monza e Brianza, Italy G M, G G and IRCCS Multimedica, Sesto San Giovanni, Milano, Italy G G
    Circ Res 114:1804-14. 2014
  4. pmc Incidence of adverse events with telmisartan compared with ACE inhibitors: evidence from a pooled analysis of clinical trials
    Giuseppe Mancia
    Universita degli Studi Milano Bicocca, Ospedale San Gerardo di Monza, Milan, Italy
    Patient Prefer Adherence 6:1-9. 2012
  5. doi request reprint The central sympathetic nervous system in hypertension
    Giuseppe Mancia
    Department of Prevention, Clinica Medica, Ospedale San Gerardo, Monza Milan, Italy Electronic address
    Handb Clin Neurol 117:329-35. 2013
  6. doi request reprint Long-term prognostic value of white coat hypertension: an insight from diagnostic use of both ambulatory and home blood pressure measurements
    Giuseppe Mancia
    Department of Health Sciences, University of Milano Bicocca, Milan, Italy
    Hypertension 62:168-74. 2013
  7. doi request reprint Dihydropiridinic Calcium-Channel Antagonists in the 2007 ESH/ESC Hypertension Guidelines
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, University of Milano Bicocca, Ospedale San Gerardo di Monza, Monza, Monza, Milan, Italy
    High Blood Press Cardiovasc Prev 15:85-90. 2008
  8. doi request reprint Ambulatory blood pressure values in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET)
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Monza, Italy
    Hypertension 60:1400-6. 2012
  9. doi request reprint Visit-to-visit blood pressure variability, carotid atherosclerosis, and cardiovascular events in the European Lacidipine Study on Atherosclerosis
    Giuseppe Mancia
    Clinica Medica and Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milan, Italy
    Circulation 126:569-78. 2012
  10. doi request reprint Visit-to-visit blood pressure variability in the European Lacidipine Study on Atherosclerosis: methodological aspects and effects of antihypertensive treatment
    Giuseppe Mancia
    Clinica Medica and Department of Clinical Medicine and Prevention, University of Milano Bicocca and San Gerardo Hospital, Monza, Italy
    J Hypertens 30:1241-51. 2012

Collaborators

Detail Information

Publications189 found, 100 shown here

  1. ncbi request reprint Metabolic syndrome in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study: daily life blood pressure, cardiac damage, and prognosis
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Milan, Italy
    Hypertension 49:40-7. 2007
    ..The contribution of metabolic syndrome components to the risk, however, is unbalanced and mainly related to blood pressure and glucose abnormalities...
  2. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by r
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Doublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:E1-40. 2007
  3. ncbi request reprint The autonomic nervous system and hypertension
    Giuseppe Mancia
    From the IRCCS Istituto Auxologico Italiano, Milano, Italy G M Clinica Medica, Dipartimento di Scienze della Salute, Universita Milano Bicocca, Monza Monza e Brianza, Italy G M, G G and IRCCS Multimedica, Sesto San Giovanni, Milano, Italy G G
    Circ Res 114:1804-14. 2014
    ....
  4. pmc Incidence of adverse events with telmisartan compared with ACE inhibitors: evidence from a pooled analysis of clinical trials
    Giuseppe Mancia
    Universita degli Studi Milano Bicocca, Ospedale San Gerardo di Monza, Milan, Italy
    Patient Prefer Adherence 6:1-9. 2012
    ..Telmisartan and ACE inhibitors are suitable for the prevention of cardiovascular events in high-risk patients, but telmisartan is better tolerated, particularly with regard to cough...
  5. doi request reprint The central sympathetic nervous system in hypertension
    Giuseppe Mancia
    Department of Prevention, Clinica Medica, Ospedale San Gerardo, Monza Milan, Italy Electronic address
    Handb Clin Neurol 117:329-35. 2013
    ..The above mentioned sympathetic abnormalities explain why adrenergic overdrive represents an important therapeutic target in the treatment of hypertension. ..
  6. doi request reprint Long-term prognostic value of white coat hypertension: an insight from diagnostic use of both ambulatory and home blood pressure measurements
    Giuseppe Mancia
    Department of Health Sciences, University of Milano Bicocca, Milan, Italy
    Hypertension 62:168-74. 2013
    ..89; P<0.0001). Thus, WCH includes subjects with a widely different long-term risk of a cardiovascular event. To identify those at higher risk, measurements of both out-of-office BPs are desirable...
  7. doi request reprint Dihydropiridinic Calcium-Channel Antagonists in the 2007 ESH/ESC Hypertension Guidelines
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, University of Milano Bicocca, Ospedale San Gerardo di Monza, Monza, Monza, Milan, Italy
    High Blood Press Cardiovasc Prev 15:85-90. 2008
    ..e. atherosclerosis. This is in line with the modern view of cardiovascular prevention as a strategy that should delay the progression to high cardiovascular risk, which, once reached, is partly irreversible...
  8. doi request reprint Ambulatory blood pressure values in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET)
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Monza, Italy
    Hypertension 60:1400-6. 2012
    ....
  9. doi request reprint Visit-to-visit blood pressure variability, carotid atherosclerosis, and cardiovascular events in the European Lacidipine Study on Atherosclerosis
    Giuseppe Mancia
    Clinica Medica and Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milan, Italy
    Circulation 126:569-78. 2012
    ....
  10. doi request reprint Visit-to-visit blood pressure variability in the European Lacidipine Study on Atherosclerosis: methodological aspects and effects of antihypertensive treatment
    Giuseppe Mancia
    Clinica Medica and Department of Clinical Medicine and Prevention, University of Milano Bicocca and San Gerardo Hospital, Monza, Italy
    J Hypertens 30:1241-51. 2012
    ....
  11. ncbi request reprint Secondary prevention of stroke: old and new evidence
    Giuseppe Mancia
    Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Aging Clin Exp Res 14:216-20. 2002
  12. ncbi request reprint Outcomes with nifedipine GITS or Co-amilozide in hypertensive diabetics and nondiabetics in Intervention as a Goal in Hypertension (INSIGHT)
    Giuseppe Mancia
    University of Milano Bicocca, St Gerardo Hospital, Monza, Milan, Italy
    Hypertension 41:431-6. 2003
    ..Our results suggest that nifedipine could be considered as first-line therapy for hypertensive diabetics...
  13. ncbi request reprint Daily life blood pressure changes are steeper in hypertensive than in normotensive subjects
    Giuseppe Mancia
    Dipartimento di Medicina Clinica, Prevenzione e Tecnologie Sanitarie, Universita di Milano Bicocca, Milano and Ospedale San Gerardo, Via Donizetti 106, 20052 Monza
    Hypertension 42:277-82. 2003
    ....
  14. ncbi request reprint The role of blood pressure variability in end-organ damage
    Giuseppe Mancia
    Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    J Hypertens Suppl 21:S17-23. 2003
    ..Future directions for research and treatment of hypertension will need to consider the circadian cycle of blood pressure, the effect of treatment on blood pressure variability, and the magnitude of blood pressure changes in daily life...
  15. ncbi request reprint Tolerability and treatment compliance with angiotensin II receptor antagonists
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Monza, Milan, Italy
    Am J Hypertens 16:1066-73. 2003
    ..Finally it provides an overview of the tolerability and compliance profile of the angiotensin II receptor antagonists, a new class of antihypertensive drugs characterized by an efficacy and safety profile...
  16. ncbi request reprint [Practice guidelines 2007 for the treatment of arterial hypertension]
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 Monza, MI
    G Ital Cardiol (Rome) 8:389-479. 2007
  17. ncbi request reprint The role of blood pressure variability in end-organ damage
    Giuseppe Mancia
    Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, , Ospedale San Gerardo, Monza, Italy
    J Hypertens Suppl 21:S17-23. 2003
    ..Future directions for research and treatment of hypertension will need to consider the circadian cycle of blood pressure, the effect of treatment on blood pressure variability, and the magnitude of blood pressure changes in daily life...
  18. ncbi request reprint 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension
    Giuseppe Mancia
    University of Milano Bicocca, Ospedale San Gerardo, Milan, Italy
    J Hypertens 25:1751-62. 2007
  19. ncbi request reprint Clinical benefits of consistent reduction in the daily blood pressure of hypertensive patients
    Giuseppe Mancia
    Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita di Milano Bicocca and Clinica Medica Ospedale S Gerardo di Tintori, Milano, Italy
    J Clin Hypertens (Greenwich) 4:9-14. 2002
    ..The most important aim of antihypertensive therapy should be the dynamic control of BP-lower BP and lower BP variability...
  20. ncbi request reprint Relationship of office, home, and ambulatory blood pressure to blood glucose and lipid variables in the PAMELA population
    Giuseppe Mancia
    Istituto di Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Ospedale S Gerardo, Monza, Milan, Italy
    Hypertension 45:1072-7. 2005
    ..Thus, in the PAMELA population, glucose and lipid values are independently related to blood pressure. This is also the case when daily life blood pressure values are considered...
  21. ncbi request reprint 2007 ESH-ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mansia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    Blood Press 16:135-232. 2007
  22. ncbi request reprint [ESH/ESC 2007 Guidelines for the management of arterial hypertension]
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Monza, Milano, Italia
    Rev Esp Cardiol 60:968.e1-94. 2007
  23. ncbi request reprint Twenty-four hour ambulatory blood pressure in the International Nifedipine GITS Study Intervention as a Goal in Hypertension Treatment (INSIGHT)
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    J Hypertens 20:545-53. 2002
    ....
  24. pmc Cardiac and vascular protection: the potential of ONTARGET
    Giuseppe Mancia
    Department of Medicine, University of Milano Bicocca, San Gerardo Hospital, Monza, Milan, Italy
    Medscape J Med 10:S7. 2008
    ..The results of the ONTARGET program are due in 2008, and the findings are expected to have important clinical implications for the management of patients at high cardiovascular risk...
  25. ncbi request reprint The association of hypertension and diabetes: prevalence, cardiovascular risk and protection by blood pressure reduction
    G Mancia
    University of Milano Bicocca, San Gerardo Hospital, Department of Clinical Medicine, Via Donizetti 106, I 20052 Monza, Milan, Italy
    Acta Diabetol 42:S17-25. 2005
    ..Such concerns should be considered in the selection of antihypertensive therapy...
  26. ncbi request reprint Blood pressure reduction and cardiovascular outcomes: past, present, and future
    Giuseppe Mancia
    Department of Medicine, University of Milan Bicocca, San Gerardo Hospital, Milan, Italy
    Am J Cardiol 100:3J-9J. 2007
    ....
  27. ncbi request reprint Prevention and treatment of stroke in patients with hypertension
    Giuseppe Mancia
    University of Milano Bicocca, St Gerardo Hospital, Monza, Milan, Italy
    Clin Ther 26:631-48. 2004
    ..Despite intensive research efforts, few effective treatments are available once stroke has occurred; thus, stroke prevention should be a primary focus for all health care providers...
  28. ncbi request reprint Guiding antihypertensive treatment decisions using ambulatory blood pressure monitoring
    Giuseppe Mancia
    Department of Clinical Medicine, Prevention and Applied Biotechnologies, and Clinica Medica, University of Milano Bicocca, St Gerardo Hospital, Via Donizetti 106, 20052 Monza, Milano, Italy
    Curr Hypertens Rep 8:330-7. 2006
    ....
  29. ncbi request reprint Hypertension and the heart
    Giuseppe Mancia
    Clinica Medica, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Milano, Italy
    Semin Cardiothorac Vasc Anesth 10:198-202. 2006
    ..Both phenomena have important clinic and therapeutic implications potentiating the cardiovascular risk profile of the hypertensive patient...
  30. ncbi request reprint Antihypertensive treatment and new-onset diabetes mellitus
    Tonje Amb Aksnes
    Clinica Medica, Ospedale S Gerardo, University of Milan Bicocca, Via Donizetti 106, 200 52 Monza, Italy
    Curr Hypertens Rep 7:298-303. 2005
    ....
  31. ncbi request reprint Blood pressure control and risk of stroke in untreated and treated hypertensive patients screened from clinical practice: results of the ForLife study
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Milan, Italy
    J Hypertens 23:1575-81. 2005
    ..The aims of this study were to assess the risk of stroke in a large cohort of hypertensive patients, and to determine the percentage with controlled blood pressure, to establish the contribution of this factor to the risk of stroke...
  32. ncbi request reprint Joint National Committee VII and European Society of Hypertension/European Society of Cardiology guidelines for evaluating and treating hypertension: a two-way road?
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Italy
    J Am Soc Nephrol 16:S74-7. 2005
    ..It also highlights the major agreements and disagreements between the two sets of guidelines and their implications for daily clinical practice...
  33. ncbi request reprint The sympathetic nervous system and the metabolic syndrome
    Giuseppe Mancia
    Ospedale San Gerardo dei Tintori, Universita Milano Bicocca, Monza, Milan, Italy
    J Hypertens 25:909-20. 2007
    ..This will be followed by an analysis of the role played by neuroadrenergic factors in disease progression as well as in the pathogenesis of its complications. Finally, the therapeutic implications of these findings will be highlighted...
  34. ncbi request reprint Assessment of long-term antihypertensive treatment by clinic and ambulatory blood pressure: data from the European Lacidipine Study on Atherosclerosis
    Giuseppe Mancia
    Clinica Medica and Department of Clinical Medicine and Prevention, University of Milano Bicocca and Ospedale S Gerardo, Monza, Milan, Italy
    J Hypertens 25:1087-94. 2007
    ..Information on the features of long-term modifications of clinic and 24-h ambulatory blood pressure (ABP) by treatment is limited. The present study aimed to address this issue...
  35. ncbi request reprint Long-term prognostic value of blood pressure variability in the general population: results of the Pressioni Arteriose Monitorate e Loro Associazioni Study
    Giuseppe Mancia
    Clinica Medica and Dipartimento di Medicina Clinica e Prevenzione, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Milan, Italy
    Hypertension 49:1265-70. 2007
    ..They also provide the first evidence that short-term erratic components of blood pressure variability play a prognostic role, with their increase being accompanied by an increased cardiovascular risk...
  36. ncbi request reprint Candesartan plus hydrochlorothiazide fixed combination vs previous monotherapy plus diuretic in poorly controlled essential hypertensive patients
    Giuseppe Mancia
    Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Blood Press Suppl 2:11-7. 2004
    ..To assess efficacy and tolerability of candesartan cilexetil (CC) plus hydrochlorothiazide (HCTZ) fixed combination vs previous monotherapy (PM) plus HCTZ in hypertension...
  37. ncbi request reprint Blood pressure control according to new guidelines targets in low- to high-risk hypertensives managed in specialist practice
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Monza, Italy
    J Hypertens 22:2387-96. 2004
    ..Few reports are available on BP control in relation to the cardiovascular risk profile in patients followed by specialist physicians...
  38. ncbi request reprint 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    Eur Heart J 28:1462-536. 2007
  39. ncbi request reprint 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    J Hypertens 25:1105-87. 2007
  40. ncbi request reprint Hypertension prevalence, awareness, control and association with metabolic abnormalities in the San Marino population: the SMOOTH study
    Giuseppe Mancia
    Clinica Medica and Department Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita di Milano Bicocca, Italy
    J Hypertens 24:837-43. 2006
    ....
  41. ncbi request reprint Long-term risk of mortality associated with selective and combined elevation in office, home, and ambulatory blood pressure
    Giuseppe Mancia
    Clinica Medica, Universita Milano Bicocca, Ospedale San Gerardo, Milan, Italy
    Hypertension 47:846-53. 2006
    ..Indeed, each BP elevation (office, home, or ambulatory) carries an increase in risk mortality that adds to that of the other BP elevations...
  42. doi request reprint Long-term risk of diabetes, hypertension and left ventricular hypertrophy associated with the metabolic syndrome in a general population
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    J Hypertens 26:1602-11. 2008
    ..Limited or no evidence exists on whether and to what extent metabolic syndrome increases the risk of developing office hypertension, daily-life hypertension and left ventricular hypertrophy...
  43. ncbi request reprint Relation between blood pressure variability and carotid artery damage in hypertension: baseline data from the European Lacidipine Study on Atherosclerosis (ELSA)
    G Mancia
    Clinica Medica, Università di Milano Bicocca and Ospedale San Gerardo, Monza, Italy
    J Hypertens 19:1981-9. 2001
    ..The aim of the present study was to determine whether IMT independently relates to additional information obtained through ambulatory BP, in particular to SBP or PP variability...
  44. ncbi request reprint Blood pressure control and improved cardiovascular outcomes in the International Verapamil SR-Trandolapril Study
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione, Universita Milano Bicocca, Milan, Italy
    Hypertension 50:299-305. 2007
    ..Consistency of BP control during treatment provides additional information on the protective effect of antihypertensive treatment. Physicians need to be concerned at each visit if BP is not controlled...
  45. pmc Statins, antihypertensive treatment, and blood pressure control in clinic and over 24 hours: evidence from PHYLLIS randomised double blind trial
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milan, Italy
    BMJ 340:c1197. 2010
    ..To investigate the possibility that statins reduce blood pressure as well as cholesterol concentrations through clinic and 24 hour ambulatory blood pressure monitoring...
  46. doi request reprint Impact of different definitions of the metabolic syndrome on the prevalence of organ damage, cardiometabolic risk and cardiovascular events
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Ospedale San Gerardo dei Tintori, Italy
    J Hypertens 28:999-1006. 2010
    ....
  47. doi request reprint Increased long-term risk of new-onset diabetes mellitus in white-coat and masked hypertension
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    J Hypertens 27:1672-8. 2009
    ..A sustained blood pressure elevation is associated with an increased risk of new-onset diabetes mellitus. Whether this is the case also in white-coat and masked hypertension is unknown...
  48. ncbi request reprint Management of essential hypertension
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, Università Milano, Milan, Italy
    Br Med Bull 94:189-99. 2010
    ....
  49. doi request reprint Protection of patients with diabetes, with or without hypertension: implications of ADVANCE for clinical practice
    Giuseppe Mancia
    Clinica Medica, Department of Medicine and Prevention, San Gerardo Hospital, University of Milan Bicocca, Monza, Milan, Italy
    J Hypertens Suppl 27:S19-23. 2009
    ....
  50. ncbi request reprint Antihypertensive efficacy of manidipine and enalapril in hypertensive diabetic patients
    G Mancia
    Clinica Medica, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    J Cardiovasc Pharmacol 35:926-31. 2000
    ..Markers of glucose and lipid metabolism and renal function were not significantly modified by treatment both with M and with E. In the diabetic hypertensives, M was as effective and metabolically neutral as the ACE-inhibitor E...
  51. ncbi request reprint Long-term risk of sustained hypertension in white-coat or masked hypertension
    Giuseppe Mancia
    Clinica Medica, Ospedale S Gerardo dei Tintori, Via Pergolesi 33, 20052 Milan, Italy
    Hypertension 54:226-32. 2009
    ..Subjects with WCHT and MHT are at increased risk of developing SHT. This may contribute to their prognosis that appears to be worse as compared with that of normotensive subjects...
  52. doi request reprint Defining blood pressure goals: is it enough to manage total cardiovascular risk?
    Giuseppe Mancia
    Clinica Medica and Dipartimento di Medicina Clinica e Prevenzione, Universita, Milano Bicocca, Ospedale San Gerardo, Monza, Milan, Italy
    J Hypertens Suppl 27:S3-8. 2009
    ..A further consideration in managing total cardiovascular risk is the need for multiple antihypertensive agents to control BP...
  53. ncbi request reprint The role of ambulatory blood pressure monitoring in elderly hypertensive patients
    G Mancia
    Clinica Medica, St Gerardo Hospital, Monza, Italy
    Blood Press Suppl 2:12-6. 2000
    ..Since 24-h blood pressure control is now widely accepted as an important goal of antihypertensive therapy, ABPM has a potentially useful role in monitoring treatment in clinical trials in elderly patients...
  54. doi request reprint Blood pressure control by the nifedipine GITS-telmisartan combination in patients at high cardiovascular risk: the TALENT study
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Italy
    J Hypertens 29:600-9. 2011
    ..Because of the complementary mechanism of action and the evidence of cardiovascular protective effects they include the combination of a calcium antagonist and an angiotensin receptor antagonist among the priorital ones to employ...
  55. ncbi request reprint What changes we may expect in 2010 hypertension diagnosis and management: Insights from the European update document
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, Universita Milano Bicocca, Ospedale San Gerardo, Monza Milan, Italy
    Curr Vasc Pharmacol 8:788-91. 2010
    ..This paper will review the novelties of the ESH update document and the implications of the "new guidelines" for current clinical practice...
  56. doi request reprint Blood pressure targets recommended by guidelines and incidence of cardiovascular and renal events in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET)
    Giuseppe Mancia
    Clinica Medica, University of Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Circulation 124:1727-36. 2011
    ..We investigated the CV and renal benefits associated with these BP targets in the high-CV-risk population of the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial (ONTARGET)...
  57. doi request reprint Heterogeneity in antihypertensive treatment discontinuation between drugs belonging to the same class
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
    J Hypertens 29:1012-8. 2011
    ..This is clinically relevant because treatment discontinuation is mainly responsible for poor blood pressure control in the antihypertensive population...
  58. doi request reprint Protective effects of renin-angiotensin blockade beyond blood pressure control
    G Mancia
    Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, Universita di Milano Bicocca, Ospedale San Gerardo, Milan, Italy
    J Hum Hypertens 23:570-7. 2009
    ..Conclusive demonstration that these blood pressure-independent effects do exist will require, however, a much more accurate and extended assessment of the blood pressure effects of the drugs...
  59. doi request reprint Impact of body mass index and waist circumference on the long-term risk of diabetes mellitus, hypertension, and cardiac organ damage
    Michele Bombelli
    Clinica Medica, Ospedale S Gerardo, Via Pergolesi 33, 20052 Monza, Italy
    Hypertension 58:1029-35. 2011
    ....
  60. doi request reprint Impact of new clinical trials on recent guidelines on hypertension management
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo dei Tintori Monza, Universita Milano Bicocca, Milan, Italy
    Ann Med 43:124-32. 2011
    ..This paper will be focused on the 2007 guidelines document and the 2009 update paper, highlighting the new concepts and recommendations provided by the most recent intervention trials...
  61. ncbi request reprint Twenty-four hour ambulatory blood pressure in the Hypertension Optimal Treatment (HOT) study
    G Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    J Hypertens 19:1755-63. 2001
    ..Office measurement, however, gives no information about blood pressure outside the office. This paper describes a HOT substudy in which patients underwent both office measurement and 24 h ambulatory blood pressure monitoring...
  62. doi request reprint Hypertension and migraine comorbidity: prevalence and risk of cerebrovascular events: evidence from a large, multicenter, cross-sectional survey in Italy (MIRACLES study)
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, St Gerardo Hospital, Monza, Milan, Italy
    J Hypertens 29:309-18. 2011
    ....
  63. ncbi request reprint Patterns of regional sympathetic nerve traffic in preascitic and ascitic cirrhosis
    M Pozzi
    Cattedra di Medicina Interna, Universita degli Studi di Milano Bicocca, Divisione di Medicina 1, Milano, Italy
    Hepatology 34:1113-8. 2001
    ..The role of drugs modulating sympathoactivation should be investigated in preascitic cirrhosis...
  64. ncbi request reprint Sympathetic and reflex abnormalities in heart failure secondary to ischaemic or idiopathic dilated cardiomyopathy
    G Grassi
    Clinica Medica, University of Milano-Bicocca, Ospedale San Gerardo dei Tintori, Via Donizetti 106, 20052 Monza-Milan, Italy
    Clin Sci (Lond) 101:141-6. 2001
    ..Thus the neuroadrenergic and reflex abnormalities characterizing CHF are independent of its aetiology...
  65. ncbi request reprint Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol) are associated with alterations in carotid intima-media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lo
    A Zanchetti
    Istituto di Clinica Medica and Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore, Milano, Italy
    J Hypertens 19:79-88. 2001
    ..While the study is in progress, baseline data are here reported to clarify the association of various risk factors with carotid IMT in these medium-high risk hypertensive patients...
  66. ncbi request reprint Alterations of cardiac structure in patients with isolated office, ambulatory, or home hypertension: Data from the general population (Pressione Arteriose Monitorate E Loro Associazioni [PAMELA] Study)
    R Sega
    Clinica Medica e Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, , Ospedale San Gerardo, Monza (Milano
    Circulation 104:1385-92. 2001
    ....
  67. ncbi request reprint Extracardiac organ damage in essential hypertensives with left ventricular concentric remodelling
    C Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    J Hum Hypertens 24:380-6. 2010
    ..These findings support the view that LVCR should be searched for and regarded as a marker of target OD with an additional value for cardiovascular risk stratification in patients with normal LVM...
  68. ncbi request reprint Progression of functional and structural cardiac alterations in young normotensive uncomplicated patients with type 1 diabetes mellitus
    S Carugo
    Department of Clinical Medicine, Prevention and Applied Biotechnology, , S. Gerardo Hospital, Monza, Italy
    J Hypertens 19:1675-80. 2001
    ..8%). CONCLUSIONS : Uncomplicated type I diabetes mellitus is characterized by early structural and functional cardiac alterations. Some of these alterations show a measurable progression within a relatively short time span...
  69. ncbi request reprint Indexation of left ventricular mass to body surface area and height to allometric power of 2.7: is the difference limited to obese hypertensives?
    C Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    J Hum Hypertens 23:728-34. 2009
    ..To avoid a systematic misclassification of cardiovascular risk, LVM should be routinely indexed to height(2.7) in overweight and obese patients representing a large percentage of the hypertensive population...
  70. ncbi request reprint Ambulatory heart rate and target organ damage in never-treated essential hypertensives
    C Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    J Hum Hypertens 22:89-95. 2008
    ..Our findings showing that 48-h ambulatory HR is not associated with markers of TOD do not support the view that a faster HR may have an additive value in predicting organ damage in the early phases of essential hypertension...
  71. ncbi request reprint Age and target organ damage in essential hypertension: role of the metabolic syndrome
    Cesare Cuspidi
    Department of Clinical Medicine, Prevention and Applied Biotechnologies, University of Milano Bicocca, Milan, Italy
    Am J Hypertens 20:296-303. 2007
    ..We sought to investigate the association of the metabolic syndrome (MS) with cardiovascular alterations in essential hypertensives in relation to age...
  72. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  73. ncbi request reprint The smoothness index: a new, reproducible and clinically relevant measure of the homogeneity of the blood pressure reduction with treatment for hypertension
    G Parati
    Medicina Interna I, Ospedale S Gerardo, Monza, Italy
    J Hypertens 16:1685-91. 1998
    ....
  74. doi request reprint Metabolic syndrome and biventricular hypertrophy in essential hypertension
    C Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    J Hum Hypertens 23:168-75. 2009
    ..Our study shows that in human hypertension, structural and functional cardiac changes induced by MS are not limited to the LV but also involve the right one...
  75. ncbi request reprint Role of echocardiography and carotid ultrasonography in stratifying risk in patients with essential hypertension: the Assessment of Prognostic Risk Observational Survey
    Cesare Cuspidi
    Istituto di Clinica Medica e Terapia Medica, Universita di Milano, Centro di Fisiologia Clinica e Ipertensione, Ospedale Maggiore and Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 20:1307-14. 2002
    ..However, current guidelines do not recommend systematic use of ultrasound examination of heart and large arteries in evaluating the cardiovascular risk in patients with hypertension...
  76. ncbi request reprint Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial
    Alberto Zanchetti
    University of Milan, Ospedale Maggiore, Istituto Auxologico Italiano, Milan, Italy
    Circulation 106:2422-7. 2002
    ..Most cardiovascular events associated with hypertension are complications of atherosclerosis. Some antihypertensive agents influence experimental models of atherosclerosis through mechanisms independent of blood pressure lowering...
  77. ncbi request reprint A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial
    Carl J Pepine
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    JAMA 290:2805-16. 2003
    ..Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials...
  78. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  79. ncbi request reprint The effect of antihypertensive agents on new-onset diabetes mellitus: time to amend the guidelines?
    Tonje Amb Aksnes
    Department of Cardiology, Ullevaal University Hospital, Oslo, Norway
    Am J Cardiovasc Drugs 6:139-47. 2006
    ..However, the key goal is still to reduce BP, and this usually requires combinations of drugs...
  80. ncbi request reprint Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives
    Guido Grassi
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita di Milano Bicocca, Milano, Italy
    J Hypertens 22:2363-9. 2004
    ..The present study was set out to compare the effects of peripheral versus central obesity on sympathetic, metabolic and reflex function...
  81. ncbi request reprint Prevalence of left ventricular hypertrophy in hypertensive patients without and with blood pressure control: data from the PAMELA population. Pressioni Arteriose Monitorate E Loro Associazioni
    Giuseppe Mancia
    Clinica Medica e Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie, Universita Milano Bicocca, Ospedale San Gerardo, Monza Milano, Italy
    Hypertension 39:744-9. 2002
    ..They also imply that even effective treatment of hypertension does not allow complete reversal of the cardiac organ damage characterizing high BP states...
  82. ncbi request reprint Clinical outcomes in the diabetes cohort of the INternational VErapamil SR-Trandolapril study
    George L Bakris
    Rush Medical University, 1700 W Van Buren St, Suite 470, Chicago, IL
    Hypertension 44:637-42. 2004
    ..Thus, a verapamil SR-based antihypertensive treatment strategy is an alternative to a beta-blocker-based strategy in adults with CAD and diabetes...
  83. ncbi request reprint The Framingham prediction rule is not valid in a European population of treated hypertensive patients
    Sylvie Bastuji-Garin
    Department of Public Health, Henri Mondor Hospital, AP HP, Paris XII University, Creteil, France
    J Hypertens 20:1973-80. 2002
    ..Stratification of population groups according to cardiovascular risk level is recommended for primary prevention...
  84. ncbi request reprint Cardiovascular risk profile and blood pressure control in Italian hypertensive patients under specialist care
    Giuseppe Mancia
    Istituto Auxologico Italiano IRCCS, Milano
    J Hypertens 22:51-7. 2004
    ..Furthermore, data on the rate of blood pressure control in the Italian hypertensive population are restricted to some Italian regions only, and refer usually to surveys performed, in most instances, several years ago...
  85. ncbi request reprint Nitric oxide dependent vasodilation in young spontaneously hypertensive rats
    A Radaelli
    Centro di Fisiologia Clinica e Ipertensione, Cattedra di Cardioangiologia Medica, Universita di Milano, Ospedale Maggiore, Milano, Italy
    Hypertension 32:735-9. 1998
    ....
  86. ncbi request reprint Short-versus long-term effects of different dihydropyridines on sympathetic and baroreflex function in hypertension
    Guido Grassi
    Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Monza, Milano, Italy
    Hypertension 41:558-62. 2003
    ..The acute sympathoexcitation, but not the small between-drugs differential chronic adrenergic effect, is accounted for by baroreflex impairment...
  87. ncbi request reprint Comparative effects of candesartan and hydrochlorothiazide on blood pressure, insulin sensitivity, and sympathetic drive in obese hypertensive individuals: results of the CROSS study
    Guido Grassi
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Monza, Italy
    J Hypertens 21:1761-9. 2003
    ....
  88. ncbi request reprint Prevalence and incidence of the metabolic syndrome in the European Lacidipine Study on Atherosclerosis (ELSA) and its relation with carotid intima-media thickness
    Alberto Zanchetti
    Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Università di Milano and Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 25:2463-70. 2007
    ..About 35% of subjects in both groups received additional hydrochlorothiazide (12.5-25 mg/day). The patients were followed up for carotid intima-media thickness (IMT) changes for 3.7 years...
  89. ncbi request reprint Sympathetic and baroreflex function in hypertensive or heart failure patients with ventricular arrhythmias
    Guido Grassi
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Italy
    J Hypertens 22:1747-53. 2004
    ..To determine whether in hypertension and in heart failure the occurrence of ventricular arrhythmias is associated with alterations in sympathetic drive and baroreflex function...
  90. ncbi request reprint Cardiac, neuroadrenergic, and portal hemodynamic effects of prolonged aldosterone blockade in postviral child A cirrhosis
    Massimo Pozzi
    Clinica Medica, Universita Milano Bicocca, Dipartimento di Radiologia, Ospedale San Gerardo, Monza, Italy
    Am J Gastroenterol 100:1110-6. 2005
    ....
  91. doi request reprint Verapamil-sustained release-based treatment strategy is equivalent to atenolol-based treatment strategy at reducing cardiovascular events in patients with prior myocardial infarction: an INternational VErapamil SR-Trandolapril (INVEST) substudy
    Sripal Bangalore
    Division of Cardiovascular Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Am Heart J 156:241-7. 2008
    ..The purpose of the study was to compare a beta-blocker-based strategy with a heart rate-lowering calcium antagonists-based strategy in patients with prior MI...
  92. ncbi request reprint Predictors of adverse outcome among patients with hypertension and coronary artery disease
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 47:547-51. 2006
    ..We sought to determine predictors for adverse outcomes in hypertensive patients with coronary artery disease (CAD)...
  93. ncbi request reprint Relationship between ambulatory blood pressure and follow-up clinic blood pressure in elderly patients with systolic hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Catholic University of Leuven, Leuven, Belgium
    J Hypertens 22:81-7. 2004
    ..On the contrary, current guidelines emphasize repeated clinic blood pressure measurements for the initiation of antihypertensive therapy...
  94. ncbi request reprint Attenuation of the "white-coat effect" by antihypertensive treatment and regression of target organ damage
    G Parati
    Clinica Medica, University of Milano Bicocca and Ospedale S Gerardo, Monza, Italy
    Hypertension 35:614-20. 2000
    ....
  95. ncbi request reprint Left ventricular and carotid structure in untreated, uncomplicated essential hypertension: results from the Assessment Prognostic Risk Observational Survey (APROS)
    C Cuspidi
    Istituto di Medicina Cardiovascolare, Universita di Milano, Milano, Italy
    J Hum Hypertens 18:891-6. 2004
    ....
  96. ncbi request reprint Lack of association between serum uric acid and organ damage in a never-treated essential hypertensive population at low prevalence of hyperuricemia
    Cesare Cuspidi
    Departement of Clinical Medicine and Prevention, University of Milano Bicocca, Italy
    Am J Hypertens 20:678-85. 2007
    ..We sought to investigate the association of SUA with subclinical cardiac, vascular, and renal alterations in never-treated uncomplicated essential hypertensives...
  97. ncbi request reprint Absolute and relative changes in carotid intima-media thickness and atherosclerotic plaques during long-term antihypertensive treatment: further results of the European Lacidipine Study on Atherosclerosis (ELSA)
    Alberto Zanchetti
    Centro Interuniversitario di Fisiologia Clinica e lpertensione, University of Milan, Milan, Italy
    J Hypertens 22:1201-12. 2004
    ....
  98. ncbi request reprint Nonpharmacologic treatment of hypertension by respiratory exercise in the home setting
    Ester Meles
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita degli Studi di Milano Bicocca, S Gerardo Hospital Monza, Italy
    Am J Hypertens 17:370-4. 2004
    ..Device-guided breathing exercises at home have a potential to become a nonpharmacologic treatment of high blood pressure (BP). The aim of this study was to evaluate the impact of device-guided breathing exercises on both office and home BP...
  99. ncbi request reprint Left ventricular geometry, ambulatory blood pressure and extra-cardiac organ damage in untreated essential hypertension
    Cesare Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    Blood Press Monit 15:124-31. 2010
    ..Thus, in untreated essential hypertensives we assessed the relationship between LV geometry, ambulatory BP and markers of vascular and renal OD...
  100. ncbi request reprint Sympathetic response to ventricular extrasystolic beats in hypertension and heart failure
    Guido Grassi
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Milan, Italy
    Hypertension 39:886-91. 2002
    ..This may represent an important factor for the genesis of the life-threatening ventricular arrhythmias that characterize CHF...