G Malerba

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. ncbi request reprint A review of asthma genetics: gene expression studies and recent candidates
    Giovanni Malerba
    Department of Mother and Child and Biology Genetics, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    J Appl Genet 46:93-104. 2005
  2. pmc Imputation reliability on DNA biallelic markers for drug metabolism studies
    Vladan Mijatovic
    Dep, of Life and Reproductions Sciences, Sec, of Biology and Genetics University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    BMC Bioinformatics 13:S7. 2012
  3. pmc Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease
    Ugo Cavallari
    Department of Mother and Child and of Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    BMC Med Genet 8:59. 2007
  4. doi request reprint SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease
    Giovanni Malerba
    Department of Mother and Child, and Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    Lipids 43:289-99. 2008
  5. ncbi request reprint Chromosome 7p linkage and GPR154 gene association in Italian families with allergic asthma
    G Malerba
    Department of Mother and Child, Biology and Genetics, University of Verona, Verona, Italy
    Clin Exp Allergy 37:83-9. 2007
  6. ncbi request reprint Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children
    G Malerba
    Department of Mother and Child, Biology and Genetics, and Department of Pathology, University of Verona, Verona, Italy
    Am J Respir Crit Care Med 162:1587-90. 2000
  7. ncbi request reprint Linkage to atopy on chromosome 19 in north-eastern Italian families with allergic asthma
    S Venanzi
    Department of Mother and Child, Biology and Genetics (DMIBG, University of Verona, Verona, Italy
    Clin Exp Allergy 31:1220-4. 2001
  8. ncbi request reprint PTCH1 gene haplotype association with basal cell carcinoma after transplantation
    A Begnini
    Department of Mother and Child, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Br J Dermatol 163:364-70. 2010
  9. doi request reprint PPARG2 Pro12Ala and ADAMTS9 rs4607103 as "insulin resistance loci" and "insulin secretion loci" in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4
    M Trombetta
    Division of Endocrinology and Metabolism, Department of Medicine, Ospedale Civile Maggiore, University of Verona, Piazzale Stefani 1, 37126, Verona, Italy
    Acta Diabetol 50:401-8. 2013
  10. ncbi request reprint No linkage or association of five polymorphisms in the interleukin-4 receptor alpha gene with atopic asthma in Italian families
    C Migliaccio
    Department of Mother and Child, University of Verone, Verone, Italy
    Eur J Immunogenet 30:349-53. 2003

Detail Information

Publications32

  1. ncbi request reprint A review of asthma genetics: gene expression studies and recent candidates
    Giovanni Malerba
    Department of Mother and Child and Biology Genetics, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    J Appl Genet 46:93-104. 2005
    ..The role of these and other genetic determinants has to be confirmed in future, preferably longitudinal, studies...
  2. pmc Imputation reliability on DNA biallelic markers for drug metabolism studies
    Vladan Mijatovic
    Dep, of Life and Reproductions Sciences, Sec, of Biology and Genetics University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    BMC Bioinformatics 13:S7. 2012
    ....
  3. pmc Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease
    Ugo Cavallari
    Department of Mother and Child and of Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    BMC Med Genet 8:59. 2007
    ..No data are available on its association with coronary artery disease (CAD)...
  4. doi request reprint SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease
    Giovanni Malerba
    Department of Mother and Child, and Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    Lipids 43:289-99. 2008
    ....
  5. ncbi request reprint Chromosome 7p linkage and GPR154 gene association in Italian families with allergic asthma
    G Malerba
    Department of Mother and Child, Biology and Genetics, University of Verona, Verona, Italy
    Clin Exp Allergy 37:83-9. 2007
    ..A fine mapping in Finnish and French-Canadian populations has associated the GPR154 gene (also known as G-protein-coupled receptor for asthma susceptibility, GPRA) with elevated IgE or asthma...
  6. ncbi request reprint Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children
    G Malerba
    Department of Mother and Child, Biology and Genetics, and Department of Pathology, University of Verona, Verona, Italy
    Am J Respir Crit Care Med 162:1587-90. 2000
    ..The region of interest centers around marker D12S390 (maximum logarithm of odds [mlod] = 2.81; p = 0.003). These results provide additional support that asthma susceptibility factors are located on chromosome 12q...
  7. ncbi request reprint Linkage to atopy on chromosome 19 in north-eastern Italian families with allergic asthma
    S Venanzi
    Department of Mother and Child, Biology and Genetics (DMIBG, University of Verona, Verona, Italy
    Clin Exp Allergy 31:1220-4. 2001
    ..3) and modest evidence of linkage of marker D19S591 (19p13.3) to the atopic phenotypes investigated were found. These results suggest that these regions may contain susceptibility loci associated to atopic phenotypes...
  8. ncbi request reprint PTCH1 gene haplotype association with basal cell carcinoma after transplantation
    A Begnini
    Department of Mother and Child, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Br J Dermatol 163:364-70. 2010
    ..Associations have been reported between PTCH1 polymorphisms and BCC susceptibility in nontransplanted individuals...
  9. doi request reprint PPARG2 Pro12Ala and ADAMTS9 rs4607103 as "insulin resistance loci" and "insulin secretion loci" in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4
    M Trombetta
    Division of Endocrinology and Metabolism, Department of Medicine, Ospedale Civile Maggiore, University of Verona, Piazzale Stefani 1, 37126, Verona, Italy
    Acta Diabetol 50:401-8. 2013
    ..03, respectively). PPARG2 and ADAMTS9 variants are both associated with T2DM and with insulin resistance, whereas only ADAMTS9 may be related to βF. Thus, at least in Italians, they may be considered bona fide "insulin resistance genes"...
  10. ncbi request reprint No linkage or association of five polymorphisms in the interleukin-4 receptor alpha gene with atopic asthma in Italian families
    C Migliaccio
    Department of Mother and Child, University of Verone, Verone, Italy
    Eur J Immunogenet 30:349-53. 2003
    ..No multipoint haplotype was associated with any phenotype. In conclusion, the IL4RA gene does not seem to play an important role in genetic predisposition to atopic asthma in the population tested...
  11. ncbi request reprint Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation
    M Gomez Lira
    Department of Mother and Child, Section of Biology and Genetics, University of Verona, Verona, Italy
    Br J Dermatol 157:49-57. 2007
    ....
  12. ncbi request reprint FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine and the Section of Biology and Genetics, University of Verona, Verona, Italy
    Am J Clin Nutr 88:941-9. 2008
    ..Single-nucleotide polymorphisms (SNPs) in FADS1 and FADS2 have been associated with different concentrations of AA and LA, and those associations have possible functional consequences for desaturase activity...
  13. ncbi request reprint The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study
    Nicola Martinelli
    University of Verona, Department of Clinical and Experimental Medicine, Italy
    Atherosclerosis 191:409-17. 2007
    ..Different genotypes, i.e., APOA5 and APOC3 variants, may lead to similar biochemical phenotypes, namely hypertriglyceridemia, but to contrasting clinical phenotypes such as the presence of angiographically proven CAD...
  14. doi request reprint Mutational and haplotype map of NOTCH3 in a cohort of Italian patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    S Testi
    Department of Neurological, Neuropsychological, Morphological and Movement Sciences Section of Neuropathology, University of Verona, Italy
    J Neurol Sci 319:37-41. 2012
    ..S396C mutation which clustered in a restricted geographical area of northeast Italy. The results added on to the genetic heterogeneity of CADASIL and emphasized difficulties in designing algorithms for molecular diagnosis...
  15. ncbi request reprint Chromosome 14 linkage analysis and mutation study of 2 serpin genes in allergic asthmatic families
    G Malerba
    Department of Mother and Child, Biology and Genetics, University of Verona, Strada La Grazie 8, 37134 Verona, Italy
    J Allergy Clin Immunol 107:654-8. 2001
    ..Genome and chromosome screens reported DNA markers on chromosome 14 linked to allergic asthma or intermediate phenotypes in several populations...
  16. doi request reprint Variants and haplotypes of TCF7L2 are associated with β-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1
    S Bonetti
    Department of Medicine, University of Verona, Verona, Italy
    J Clin Endocrinol Metab 96:E389-93. 2011
    ..Intronic variants of TCF7L2 are confirmed genetic risk factors for type 2 diabetes and are associated to alterations in beta cell function in nondiabetic individuals...
  17. ncbi request reprint On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease
    Elisabetta Trabetti
    Department of Mother and Child and of Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    Eur J Hum Genet 14:127-30. 2006
    ..Even if the OLR1 genotype frequency distribution data in CAD or AMI subjects here reported do not fully confirm the positive results of some other association studies, an association with a marker of CAD severity was observed...
  18. doi request reprint Fully non-homogeneous hidden Markov model double net: a generative model for haplotype reconstruction and block discovery
    Alessandro Perina
    Department of Computer Science, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy
    Artif Intell Med 45:135-50. 2009
    ..Such tasks are usually addressed separately, but recently, statistical techniques have permitted them to be solved jointly. Following this trend we propose a generative model that permits researchers to solve the two problems jointly...
  19. ncbi request reprint ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study
    Domenico Girelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Eur J Hum Genet 15:959-66. 2007
    ..Our angiography-based study suggests a possible modest role of ALOX5AP in the development of the atheroma rather than in its late thrombotic complications such as MI...
  20. ncbi request reprint Charcot-Marie-Tooth disease type 2E, a disorder of the cytoskeleton
    Gian Maria Fabrizi
    Section of Clinical Neurology, Department of Neurological and Visual Sciences, University of Verona, Italy
    Brain 130:394-403. 2007
    ..The pathological phenotype correlated with the pattern of nerve conduction alterations and indicated that NEFL mutations cause a profound alteration of the cytoskeleton possibly related to defective targeting of NF...
  21. doi request reprint Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile
    Nicola Martinelli
    Department of Medicine, University of Verona, Verona, Italy
    Blood 116:5688-97. 2010
    ..67 with 95% confidence interval, 1.10-2.54). Haplotype analysis confirmed such results. Our data suggest that polymorphisms at LDLR locus modulate FVIII:c levels and may be associated with CAD risk independently from plasma lipids...
  22. doi request reprint Upregulated expression of Toll-like receptor 4 in peripheral blood of ischaemic stroke patients correlates with cyclooxygenase 2 expression
    S Ferronato
    Department of Life and Reproduction Sciences, Section of Biology and Genetics, University of Verona, Verona, Italy
    Eur J Vasc Endovasc Surg 41:358-63. 2011
    ..The aim of the study was to investigate if genes involved in the cyclooxygenase 2 (COX-2) pathway are upregulated at peripheral level in patients after transient ischaemic attack (TIA) and stroke...
  23. ncbi request reprint COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk
    S Mazzola
    Department of Mother and Child, Biology and Genetics, Section Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Int J Immunogenet 34:71-4. 2007
    ..Screening of the proximal 5' regulatory region and genotyping of -765G>C and -62C>G showed that polymorphisms in this COX-2 region are unlikely to be involved in MS susceptibility...
  24. doi request reprint IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C
    G Fattovich
    Clinic of Gastroenterology, Department of Medicine, University of Verona, Piazzale L A Scuro 10, Verona, Italy
    Aliment Pharmacol Ther 33:1162-72. 2011
    ..Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma and the identification of the predictors of response to antiviral therapy is an important clinical issue...
  25. ncbi request reprint Glutathione S-transferase and CYP1A1 gene polymorphisms and non-melanoma skin cancer risk in Italian transplanted patients
    Macarena Gomez Lira
    Section of Biology and Genetics, University of Verona, Verona, Italy
    Exp Dermatol 15:958-65. 2006
    ....
  26. pmc Genetic risk for recurrent urinary tract infections in humans: a systematic review
    M Zaffanello
    Department of Mother Child and Biology Genetics, Section of Pediatrics, University of Verona, Piazzale L Scuro 10, 37134 Verona, Italy
    J Biomed Biotechnol 2010:321082. 2010
    ..In particular, the HSPA1B, CXCR1 & 2, TLR2, TLR4, TGF-beta1 genes seem to be associated with an alteration of the host response to UTIs at various levels...
  27. ncbi request reprint Relationship among VDR (BsmI and FokI), COLIA1, and CTR polymorphisms with bone mass, bone turnover markers, and sex hormones in men
    V Braga
    Rheumatology Unit, Valeggio S M, University of Verona, Italy
    Calcif Tissue Int 70:457-62. 2002
    ..The lower BMD in CC genotype is apparently associated in males with depressed bone formation and lower estradiol levels...
  28. ncbi request reprint Association of CTR and COLIA1 alleles with BMD values in peri- and postmenopausal women
    V Braga
    Department of Rheumatology, Valeggio S M, University of Verona, Verona, Italy
    Calcif Tissue Int 67:361-366. 2000
    ..These findings suggest an association between the COLIA1 gene polymorphism more with the age-related rate of bone loss than with peak bone mass, which apparently is somewhat affected by CTR gene polymorphism...
  29. ncbi request reprint The genetic background of osteoporosis in cystic fibrosis: association analysis with polymorphic markers in four candidate genes
    Carlo Castellani
    Cystic Fibrosis Center, Pediatric Department, Azienda Ospedaliera, Verona, Italy
    J Cyst Fibros 5:229-35. 2006
    ..Reduced Bone Mass Density (BMD) is frequent in Cystic Fibrosis (CF). Potentially, other genes than the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene may contribute to the bone phenotype variability in CF patients...
  30. ncbi request reprint Association of the interleukin-1 receptor antagonist gene with asthma
    Henning Gohlke
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Am J Respir Crit Care Med 169:1217-23. 2004
    ..The most frequent haplotype constructed from these SNPs was 1.4-fold overtransmitted in the German family sample...
  31. pmc IRAK-M is involved in the pathogenesis of early-onset persistent asthma
    Lenuta Balaci
    Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Cagliari, Onserrato, Italy
    Am J Hum Genet 80:1103-14. 2007
    ..Our data suggest a mechanistic link between hyperactivation of the innate immune system and chronic airway inflammation and indicate IRAK-M as a potential target for therapeutic intervention against asthma...
  32. ncbi request reprint Complement receptor 1 gene polymorphisms in sarcoidosis
    Michele Zorzetto
    Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, Pavia, Italy
    Am J Respir Cell Mol Biol 27:17-23. 2002
    ..The same genotype was particularly associated to disease in females (OR = 7.05; 95% CI 3.10-16.61 versus healthy control subjects). These findings agree with speculations on the role of CR1 gene as a possible susceptibility factor...