Fabio Malavasi

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi CD157, the Janus of CD38 but with a unique personality
    Erika Ortolan
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Turin, Italy
    Cell Biochem Funct 20:309-22. 2002
  2. doi Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
    Fabio Malavasi
    Laboratory of Immunogenetics, Department of Genetics, Biology, and Biochemistry and Centro di Ricerca in Medicina Sperimentale, University of Torino Medical School, Torino, Italy
    Physiol Rev 88:841-86. 2008
  3. pmc CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity
    Fabio Malavasi
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Mol Med 12:334-41. 2006
  4. doi The hidden life of NAD+-consuming ectoenzymes in the endocrine system
    Fabio Malavasi
    Laboratory of Immunogenetics and CeRMS, Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Turin, Italy
    J Mol Endocrinol 45:183-91. 2010
  5. ncbi CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells
    Silvia Deaglio
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, Via Santena 19, 10126 Turin, Italy
    Blood 102:2146-55. 2003
  6. pmc CD38 and chronic lymphocytic leukemia: a decade later
    Fabio Malavasi
    Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Torino, Italy
    Blood 118:3470-8. 2011
  7. pmc The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia
    Davide Brusa
    Human Genetics Foundation HuGeF and Department of Medical Sciences, University of Turin, Turin, Italy
    Haematologica 98:953-63. 2013
  8. doi CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?
    Semra Aydin
    Department of Genetics, Biology, and Biochemistry, University of Torino Medical School, Turin, Italy
    Blood 111:5646-53. 2008
  9. ncbi CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival
    Silvia Deaglio
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Blood 105:3042-50. 2005
  10. pmc CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
    Sara Serra
    Human Genetics Foundation HuGeF, Turin, Italy
    Blood 118:6141-52. 2011

Detail Information

Publications67

  1. ncbi CD157, the Janus of CD38 but with a unique personality
    Erika Ortolan
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Turin, Italy
    Cell Biochem Funct 20:309-22. 2002
    ..Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell...
  2. doi Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
    Fabio Malavasi
    Laboratory of Immunogenetics, Department of Genetics, Biology, and Biochemistry and Centro di Ricerca in Medicina Sperimentale, University of Torino Medical School, Torino, Italy
    Physiol Rev 88:841-86. 2008
    ..The concluding remarks try to frame all of the currently available information within a unified working model that takes into account both the enzymatic and receptorial functions of the molecules...
  3. pmc CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity
    Fabio Malavasi
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Mol Med 12:334-41. 2006
    ..As an extra analytical tool, we try to follow in the history of life when the enzymatic and receptorial functions were generated, mixing ontogeny, membrane localization, and cell anchorage...
  4. doi The hidden life of NAD+-consuming ectoenzymes in the endocrine system
    Fabio Malavasi
    Laboratory of Immunogenetics and CeRMS, Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Turin, Italy
    J Mol Endocrinol 45:183-91. 2010
    ..This review will try to read the available evidence in a hypothesis-oriented perspective, starting from the description of NAD(+) and of ecto- and endoenzymes involved in its metabolism...
  5. ncbi CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells
    Silvia Deaglio
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, Via Santena 19, 10126 Turin, Italy
    Blood 102:2146-55. 2003
    ..Finally, CD38 signaling in IL-2-treated B-CLL cells prolonged survival and induced the appearance of plasmablasts, providing a pathogenetic hypothesis for the occurrence of Richter syndrome...
  6. pmc CD38 and chronic lymphocytic leukemia: a decade later
    Fabio Malavasi
    Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Torino, Italy
    Blood 118:3470-8. 2011
    ..The second decade of studies on CD38 in CLL will tell if the molecule is an effective target for antibody-mediated therapy in this currently incurable leukemia...
  7. pmc The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia
    Davide Brusa
    Human Genetics Foundation HuGeF and Department of Medical Sciences, University of Turin, Turin, Italy
    Haematologica 98:953-63. 2013
    ..These observations suggest that pharmacological manipulation of the PD-1/PD-L1 axis may contribute to restoring T-cell functions in the chronic lymphocytic leukemia microenvironment...
  8. doi CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?
    Semra Aydin
    Department of Genetics, Biology, and Biochemistry, University of Torino Medical School, Turin, Italy
    Blood 111:5646-53. 2008
    ..Multivariate analysis on a total of 30 RS patients confirmed that the probability of transformation is strongly associated with G allele, likely representing an independent risk factor for RS development...
  9. ncbi CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival
    Silvia Deaglio
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Blood 105:3042-50. 2005
    ....
  10. pmc CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
    Sara Serra
    Human Genetics Foundation HuGeF, Turin, Italy
    Blood 118:6141-52. 2011
    ..These data are consistent with the existence of an autocrine adenosinergic loop, and support engraftment of leukemic cells in growth-favorable niches, while simultaneously protecting from the action of chemotherapeutic agents...
  11. ncbi CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential
    Silvia Deaglio
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy
    Blood 110:4012-21. 2007
    ....
  12. pmc CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells
    Silvia Deaglio
    Department of Genetics, Biology and Biochemistry, of Torino Medical School, Turin, Italy
    Mol Med 16:87-91. 2010
    ..These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites...
  13. pmc Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque
    Enza Ferrero
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 19 and the CeRMS Research Center for Experimental Medicine, 10126 Torino, Italy
    BMC Immunol 5:21. 2004
    ..This study originated from an inherent interest in studying CD38 in the cynomolgus monkey (Macaca fascicularis), a species closely related to humans that also represents a cogent animal model for the biomedical analysis of CD38...
  14. ncbi In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia
    Silvia Deaglio
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Italy
    Blood 108:1135-44. 2006
    ..This would result in acquisition of increased survival potential, providing clues to the poorer prognosis of CD38(+) patients...
  15. ncbi CD38/CD19: a lipid raft-dependent signaling complex in human B cells
    Silvia Deaglio
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Blood 109:5390-8. 2007
    ..Our inability to identify a correlation between the production of cADPR and the receptorial functions support the hypothesis that CD38 is a pleiotropic molecule whose behavior as a receptor is independent from its enzymatic activity...
  16. ncbi CD157 plays a pivotal role in neutrophil transendothelial migration
    Erika Ortolan
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Medical School, Via Santena 19, 10126 Torino, Italy
    Blood 108:4214-22. 2006
    ..These findings are relevant in vivo because CD157-deficient neutrophils obtained from patients with paroxysmal nocturnal hemoglobinuria are characterized by a severely impaired diapedesis...
  17. doi CD38 at the junction between prognostic marker and therapeutic target
    Silvia Deaglio
    Department of Genetics, Laboratory of Immunogenetics, Biology and Biochemistry and CERMS, Via Santena 19, 10126 Torino, Italy
    Trends Mol Med 14:210-8. 2008
    ..The use of reagents specifically blocking the molecule might provide a new approach for interfering with deleterious growth circuits, therefore increasing the susceptibility of leukemic cells to conventional chemotherapy...
  18. doi Binding of prostate-specific membrane antigen to dendritic cells: a critical step in vaccine preparation
    Stefano Garetto
    Laboratory of Tumor Immunology, Department of Internal Medicine, University of Turin, Turin, Italy
    Cytotherapy 11:1090-100. 2009
    ..We evaluated the actual binding of selected HLA-A2-restricted PSMA peptides to HLA class I molecules on ex vivo-generated mature (m) DC...
  19. pmc CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbus
    Alberto L Horenstein
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Mol Med 15:76-84. 2009
    ..The presence and characteristics of these ectoenzymes may be exploited to design drugs for wound repair or for applications in tissue transplantation...
  20. ncbi CD157 is an important mediator of neutrophil adhesion and migration
    Ada Funaro
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 19, 10126 Torino, Italy
    Blood 104:4269-78. 2004
    ..These neutrophils showed constant defects in adhesion and migration. Our data attribute specific and crucial roles to CD157 in the regulation of innate immunity during inflammation...
  21. pmc Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells
    Luisella Righi
    Department of Genetics, Biology, and Biochemistry, Laboratory of Immunogenetics, University of Torino Medical School, Torino, Italy
    Am J Pathol 162:1163-74. 2003
    ..In conclusion, CD31 expression reverts the undifferentiated morphology and aggressive behavior of MDA-MB-231 cells, indicating its active role in the morphogenesis of breast ductal in situ carcinomas...
  22. ncbi Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells
    Silvia Deaglio
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, Turin, Italy
    Blood 99:2490-8. 2002
    ..This molecule is CD16 in NK cells...
  23. pmc Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells
    Ada Funaro
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Torino, Italy
    BMC Biotechnol 8:85. 2008
    ....
  24. ncbi Functional, structural, and distribution analysis of the chorionic gonadotropin receptor using murine monoclonal antibodies
    Ada Funaro
    Department of Genetics, Biology and Biochemistry and Research Center for Experimental Medicine, University of Torino, Torino 10126, Italy
    J Clin Endocrinol Metab 88:5537-46. 2003
    ..This observation suggests that the mAb recognizes an epitope that is included in the domain of the receptor involved in the interaction with the natural ligand...
  25. doi CD38 and CD157: a long journey from activation markers to multifunctional molecules
    Valeria Quarona
    Department of Medical Sciences, Laboratory of Immunogenetics, University of Torino Medical School, Torino, Italy
    Cytometry B Clin Cytom 84:207-17. 2013
    ..Future tasks will be to explore their potential as targets for in vivo therapeutic interventions and as regulators of the immune response...
  26. doi Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options
    Valentina Audrito
    Department of Medical Sciences, University of Turin, School of Medicine, Turin, Italy Human Genetics Foundation HuGeF, Turin, Italy
    Cancer Lett 328:27-35. 2013
    ..At the same time, it seeks to hone in on which discrete molecular elements are best suited as targets for treating this still incurable disease...
  27. doi NAD+-metabolizing ecto-enzymes shape tumor-host interactions: the chronic lymphocytic leukemia model
    Tiziana Vaisitti
    Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    FEBS Lett 585:1514-20. 2011
    ..We have exploited chronic lymphocytic leukemia as a model to test the role of the ecto-enzyme network, starting by analyzing the individual elements that make up the whole picture...
  28. doi Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network
    Valentina Audrito
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Turin, Rome, Italy
    Cancer Res 71:4473-83. 2011
    ..These observations suggested the therapeutic potential of nicotinamide, a novel, safe, and inexpensive drug, to be used in addition to chemotherapy for CLL patients with wt p53...
  29. ncbi Ectoenzymes and innate immunity: the role of human CD157 in leukocyte trafficking
    Ada Funaro
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Torino, Italy
    Front Biosci (Landmark Ed) 14:929-43. 2009
    ..Indeed, CD157-mediated signals promote cell polarization, regulate chemotaxis induced through the high affinity fMLP receptor and control transendothelial migration...
  30. ncbi Contribution of dendritic cells' FcgammaRI and FcgammaRIII to cross-presentation of tumor cells opsonized with the anti-MHC class I monoclonal antibodies
    Elena Signorino
    Laboratory of Tumor Immunology, University of Turin, Turin, Italy
    Cancer Biol Ther 6:1932-7. 2007
    ....
  31. ncbi CD157 at the intersection between leukocyte trafficking and epithelial ovarian cancer invasion
    Nicola Lo Buono
    Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy
    Front Biosci (Landmark Ed) 19:366-78. 2014
    ..In this review, we will discuss the biological mechanisms underpinning the role of CD157 in the control of leukocyte migration and ovarian cancer dissemination. ..
  32. ncbi Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum
    Silvia Deaglio
    Laboratory of Immunogenetics, Department of Genetics, Biology, and Biochemistry, the Experimental Medicine Research Center, University of Turin Medical School, Italy
    Blood 100:3782-9. 2002
    ..The tissue distribution pattern, the behavior following exposure to iron-loaded TF, and the features of the disease resulting from TFR-2 inactivation support the hypothesis that TFR-2 contributes to body iron sensing...
  33. ncbi CD38 and bone marrow microenvironment
    Antonella Chillemi
    Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino Medical School, Via Santena 19, 10126 Torino, Italy
    Front Biosci (Landmark Ed) 19:152-62. 2014
    ..Consequently, not only might CD38 be a prime target for mAb-mediated therapy, but its functional block may contribute to general improvement in cancer immunotherapy and outcomes. ..
  34. ncbi Design and scaleup of downstream processing of monoclonal antibodies for cancer therapy: from research to clinical proof of principle
    Alberto L Horenstein
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy
    J Immunol Methods 275:99-112. 2003
    ..Not less importantly, all the techniques applied are characterized by costs which are affordable to medium-sized laboratories. They represent the basis for implementing immunotherapeutic protocols transferable to clinical medicine...
  35. doi CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cells
    Silvia Deaglio
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy
    Semin Cancer Biol 20:416-23. 2010
    ..In addition to driving the clinical outcome of the disease, CD38 is thus an excellent candidate therapeutic target for a significant subset of CLL patients...
  36. pmc Anti-CD38 antibody therapy: windows of opportunity yielded by the functional characteristics of the target molecule
    Antonella Chillemi
    Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino Medical School, Torino, Italy
    Mol Med 19:99-108. 2013
    ..Consequently, not only might CD38 be a prime target for mAb-mediated therapy, but its functional block may contribute to general improvement in cancer immunotherapy and outcomes...
  37. ncbi Purification of clinical-grade monoclonal antibodies by chromatographic methods
    Alberto L Horenstein
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School and Research Center for Experimental Medicine CeRMS, San Giovanni Battista Hospital, Turin, Italy
    Methods Mol Biol 308:191-208. 2005
  38. pmc Different aquaporin-4 expression in glioblastoma multiforme patients with and without seizures
    Gianluca Isoardo
    Unit of Clinical Neurophysiology, Department of Neurosurgery, CTO Hospital, Torino, Italy
    Mol Med 18:1147-51. 2012
    ..001). We conclude that reduced expression of cell surface AQP-4 is characteristic of GBM patients without seizures, likely attributable to a posttranslational mechanism...
  39. ncbi CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells
    Loredana Frasca
    Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Blood 107:2392-9. 2006
    ..These findings may lay out the basis to assess the functional role(s) of human CD38 in infections, autoimmune diseases, and neoplastic disorders...
  40. ncbi CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor
    Pilar Munoz
    Instituto de Parasitologia y Biomedicina, Consejo Superior de Investigaciones Cientificas, 18001 Granada, Spain
    J Biol Chem 278:50791-802. 2003
    ..Overall, these findings provide the first evidence that CD38 operates in two functionally distinct microdomains of the plasma membrane...
  41. ncbi CD38 is expressed on human mature monocyte-derived dendritic cells and is functionally involved in CD83 expression and IL-12 induction
    Giorgio Fedele
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 34:1342-50. 2004
    ..Activation via agonistic anti-CD38 mAb induces up-regulation of CD83 expression and IL-12 secretion, whereas disruption of CD38/CD31 interaction inhibits CD83 expression, IL-12 secretion and MDDC-induced allogeneic T cell proliferation...
  42. ncbi CD38 is a marker of human lacteals
    Inger Nina Farstad
    Laboratory for Immunohistochemistry and Immunopathology, Rikshospitalet, University of Oslo, Norway
    Virchows Arch 441:605-13. 2002
    ..CD38 was not detected on lymphatics in other organs or in rodent lacteals. We propose that CD38 is a novel marker of human small intestinal lymphatic vessels...
  43. ncbi Peripheral blood CD38 expression predicts time to progression in B-cell chronic lymphocytic leukemia after first-line therapy with high-dose chlorambucil
    Fortunato Morabito
    Haematologica 87:217-8. 2002
    ....
  44. ncbi Death of T cell precursors in the human thymus: a role for CD38
    Claudya Tenca
    Section of Human Anatomy, Department of Experimental Medicine, University of Genova, 16132 Genova, Italy
    Int Immunol 15:1105-16. 2003
    ..In addition, CD28 expression on developing thymocytes also appears to play a role for their selection and it synergizes with CD38 to induce apoptosis of DP thymocytes...
  45. ncbi CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifs
    Mercedes Zubiaur
    Hospital Universitario San Cecilio, Granada 18012, Spain
    J Biol Chem 277:13-22. 2002
    ....
  46. ncbi Retinoic acid-induced CD38 antigen as a target for immunotoxin-mediated killing of leukemia cells
    Kapil Mehta
    Department of Bioimmunotherapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mol Cancer Ther 3:345-52. 2004
    ..Our results suggest that RA combined with anti-CD38-based therapeutic agent may offer exciting opportunities for the treatment of myeloid leukemias despite their multiplicity of genetic and clinical varieties...
  47. ncbi Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia
    Jan Dürig
    Department of Hematology, Medical Faculty, University of Essen, Germany
    Blood 101:2748-55. 2003
    ..05). Our data show that gene expression profiling can help identify B-CLL subtypes with different clinical characteristics. Furthermore, our results suggest a role of translation-associated genes in the pathogenesis of B-CLL...
  48. ncbi Human CD38 interferes with HIV-1 fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120
    Andrea Savarino
    Laboratory of Immunology, Interdisciplinary Research Center of Autoimmune Diseases, Department of Medical Science, University of Eastern Piedmont, Novara, Italy
    FASEB J 17:461-3. 2003
    ..Conversely, a deletion in the V3-like region abrogated the anti-HIV-1 activity of CD38 and its lateral association with CD4. These findings may provide new insights into the early events of HIV-1 fusion and strategies to intervene...
  49. ncbi CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes
    Roberto Lande
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, 00161, Rome, Italy
    Cell Immunol 220:30-8. 2002
    ..The key element for the receptor mediated signaling is represented by surface density of CD38 on resting monocytes...
  50. ncbi TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway
    Alessia Calzolari
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Cell Sci 119:4486-98. 2006
    ..In conclusion, the present study indicates that TfR2 localizes in LDTI microdomains, where it promotes cell signalling, and is exported out of the cells through the exosome pathway, where it acts as an intercellular messenger...
  51. ncbi Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation
    Friedrich Koch-Nolte
    Institute of Immunology, University Hospital, 20246 Hamburg, Germany
    Cell Immunol 236:66-71. 2005
    ..ART1 and ART4 have been assigned the designations: CD296, and CD297, respectively...
  52. ncbi Simultaneous expression of CD38 and its ligand CD31 by chronic lymphocytic leukemia B-cells: anecdotal observation or pathogenetic hypothesis for the clinical outcome?
    Fortunato Morabito
    Haematologica 88:354-5. 2003
  53. ncbi Prognostic significance of combined analysis of ZAP-70 and CD38 in chronic lymphocytic leukemia
    Giovanni D'Arena
    Hematology Oncology Unit, National Cancer Institute, Fondazione G Pascale, Via Mariano Semmola, Naples, Italy
    Am J Hematol 82:787-91. 2007
    ....
  54. ncbi The role of platelet/endothelial cell adhesion molecule 1 (CD31) and CD38 antigens in marrow microenvironmental retention of acute myelogenous leukemia cells
    Nathalie Gallay
    INSERM ESPRI EA3855, Universite Francois Rabelais, Tours, France
    Cancer Res 67:8624-32. 2007
    ..Importantly, the excess of CD31 in those samples was associated with a higher peripheral WBC count. These findings indicate that bone marrow retention of AML cells depends on CD31 and CD38 coexpression levels...
  55. ncbi A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens
    Ines Parusel
    Institute of Immunology, University Hospital, Hamburg, Germany
    Cell Immunol 236:59-65. 2005
    ..Neither of the mAbs reacted with mouse ART4-transfected cells, but NONI-B63 and MIMA-53 did react with a mouse/human ART4 chimera, indicating that the epitope recognized by these mAbs lies in the C-terminal half of the protein...
  56. doi Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse
    Pilar Munoz
    Departamento de Biología Celular e Immunología, Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Armilla, Spain
    Blood 111:3653-64. 2008
    ..These results reveal a new role for CD38 in modulating antigen-mediated T-cell responses during IS formation...
  57. ncbi IFN-gamma arms human dendritic cells to perform multiple effector functions
    Loredana Frasca
    Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 180:1471-81. 2008
    ..These data also help understand the dual role exerted by this cytokine as both an inducer and a regulator of inflammation and immune response...
  58. ncbi The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus
    Sonia Molina
    INSERM, U632, Hepatic Physiopathology, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    J Hepatol 46:411-9. 2007
    ..The direct implication of low-density lipoprotein receptor (LDLR) in hepatitis C virus (HCV) infection of human hepatocyte has not been demonstrated. Normal primary human hepatocytes infected by serum HCV were used to document this point...
  59. ncbi CD molecules 2006--human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute and Adelaide University Discipline of Paediatrics, 72 King William Road, North Adelaide, South Australia 5006, Australia
    J Immunol Methods 319:1-5. 2007
    ..At that meeting the Council, acting as Nomenclature Committee, approved a number of new CD designations and changes to some pre-existing CD designations, which are summarized in this report...
  60. pmc Transferrin receptor 2 protein is not expressed in normal erythroid cells
    Alessia Calzolari
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochem J 381:629-34. 2004
    ..The implications of this observation for the understanding of the phenotypic features of haemochromatosis due to mutation of the TFR2 gene are discussed...
  61. ncbi Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effects
    Germano Baj
    Laboratories of Gynecologic Oncology, University of Eastern Piedmont A Avogadro, Novara, Italy
    Breast Cancer Res Treat 73:61-73. 2002
    ....
  62. ncbi Immunodetection of anti-MAG IgM antibody by cross-reactivity to LA-N-1 neuroblastoma cells
    Gianluca Isoardo
    SOC Neurologia, Ospedale Civile di Asti, 14100 Asti, Italy
    J Neuroimmunol 161:78-86. 2005
    ..We report here on the evaluation of the LA-N-1 cell line as an appropriate substrate for the detection of anti-MAG antibody by indirect immunoflourescence...
  63. ncbi Transferrin receptor 2 is frequently expressed in human cancer cell lines
    Alessia Calzolari
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Blood Cells Mol Dis 39:82-91. 2007
    ..Furthermore, our studies indicate that, at least in tumor cells, TfR2 expression is modulated by iron through different biochemical mechanisms, whose molecular basis remains to be determined...
  64. ncbi Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Int Immunol 14:883-92. 2002
    ..CCR1, CCR2 and CCR4 were detected by flow cytometry on non-GC (i.e. naive and memory) B cells, whereas they were absent (CCR1 and CCR2) or poorly expressed (CCR4) on GC B cells...
  65. ncbi Radioimmunotherapy in advanced ovarian cancer: is there a role for pre-targeting with (90)Y-biotin?
    Chiara Grana
    Division of Nuclear Medicine, European Institute of Oncology, Milano, Italy
    Gynecol Oncol 93:691-8. 2004
    ..Pre-targeting RIT, based on the avidin-biotin system, has been the objective of previous studies performed by our group...
  66. ncbi Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine
    Christian Krebs
    Institute of Immunology, University Hospital, Martinistrasse 52, D 20246, Hamburg, Germany
    Anal Biochem 314:108-15. 2003
    ..The immunoblot 1G4 staining assay can also be used to identify etheno-ADP-ribosylated target proteins. These new assays hold promise for many interesting applications in biochemistry and cell biology...
  67. ncbi CD molecules 2005: human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute, 72 King William Rd, North Adelaide 5006, South Australia, Australia
    Blood 106:3123-6. 2005
    ....