Research Topics
Genomes and Genes | Fabio MalavasiSummaryAffiliation: University of Turin Country: Italy Publications
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Publications
CD157, the Janus of CD38 but with a unique personalityErika Ortolan
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Turin, Italy
Cell Biochem Funct 20:309-22. 2002..Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell...- CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cellsSilvia Deaglio
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, Via Santena 19, 10126 Turin, Italy
Blood 102:2146-55. 2003..Finally, CD38 signaling in IL-2-treated B-CLL cells prolonged survival and induced the appearance of plasmablasts, providing a pathogenetic hypothesis for the occurrence of Richter syndrome... 
CD38 and chronic lymphocytic leukemia: a decade laterFabio Malavasi
Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Torino, Italy
Blood 118:3470-8. 2011..The second decade of studies on CD38 in CLL will tell if the molecule is an effective target for antibody-mediated therapy in this currently incurable leukemia...- CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunityFabio Malavasi
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
Mol Med 12:334-41. 2006..As an extra analytical tool, we try to follow in the history of life when the enzymatic and receptorial functions were generated, mixing ontogeny, membrane localization, and cell anchorage... 
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathologyFabio Malavasi
Laboratory of Immunogenetics, Department of Genetics, Biology, and Biochemistry and Centro di Ricerca in Medicina Sperimentale, University of Torino Medical School, Torino, Italy
Physiol Rev 88:841-86. 2008..The concluding remarks try to frame all of the currently available information within a unified working model that takes into account both the enzymatic and receptorial functions of the molecules...- The hidden life of NAD+-consuming ectoenzymes in the endocrine systemFabio Malavasi
Laboratory of Immunogenetics and CeRMS, Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Turin, Italy
J Mol Endocrinol 45:183-91. 2010..This review will try to read the available evidence in a hypothesis-oriented perspective, starting from the description of NAD(+) and of ecto- and endoenzymes involved in its metabolism... - CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survivalSilvia Deaglio
Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
Blood 105:3042-50. 2005.... - CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?Semra Aydin
Department of Genetics, Biology, and Biochemistry, University of Torino Medical School, Turin, Italy
Blood 111:5646-53. 2008..Multivariate analysis on a total of 30 RS patients confirmed that the probability of transformation is strongly associated with G allele, likely representing an independent risk factor for RS development... - CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell deathSara Serra
Human Genetics Foundation HuGeF, Turin, Italy
Blood 118:6141-52. 2011..These data are consistent with the existence of an autocrine adenosinergic loop, and support engraftment of leukemic cells in growth-favorable niches, while simultaneously protecting from the action of chemotherapeutic agents... - CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cellsSilvia Deaglio
Department of Genetics, Biology and Biochemistry, of Torino Medical School, Turin, Italy
Mol Med 16:87-91. 2010..These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites... - CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potentialSilvia Deaglio
Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy
Blood 110:4012-21. 2007.... - Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaqueEnza Ferrero
Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 19 and the CeRMS Research Center for Experimental Medicine, 10126 Torino, Italy
BMC Immunol 5:21. 2004..This study originated from an inherent interest in studying CD38 in the cynomolgus monkey (Macaca fascicularis), a species closely related to humans that also represents a cogent animal model for the biomedical analysis of CD38... - In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemiaSilvia Deaglio
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Italy
Blood 108:1135-44. 2006..This would result in acquisition of increased survival potential, providing clues to the poorer prognosis of CD38(+) patients... - Binding of prostate-specific membrane antigen to dendritic cells: a critical step in vaccine preparationStefano Garetto
Laboratory of Tumor Immunology, Department of Internal Medicine, University of Turin, Turin, Italy
Cytotherapy 11:1090-100. 2009..We evaluated the actual binding of selected HLA-A2-restricted PSMA peptides to HLA class I molecules on ex vivo-generated mature (m) DC... - CD38/CD19: a lipid raft-dependent signaling complex in human B cellsSilvia Deaglio
Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
Blood 109:5390-8. 2007..Our inability to identify a correlation between the production of cADPR and the receptorial functions support the hypothesis that CD38 is a pleiotropic molecule whose behavior as a receptor is independent from its enzymatic activity... - CD157 plays a pivotal role in neutrophil transendothelial migrationErika Ortolan
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Medical School, Via Santena 19, 10126 Torino, Italy
Blood 108:4214-22. 2006..These findings are relevant in vivo because CD157-deficient neutrophils obtained from patients with paroxysmal nocturnal hemoglobinuria are characterized by a severely impaired diapedesis... - CD38 at the junction between prognostic marker and therapeutic targetSilvia Deaglio
Department of Genetics, Laboratory of Immunogenetics, Biology and Biochemistry and CERMS, Via Santena 19, 10126 Torino, Italy
Trends Mol Med 14:210-8. 2008..The use of reagents specifically blocking the molecule might provide a new approach for interfering with deleterious growth circuits, therefore increasing the susceptibility of leukemic cells to conventional chemotherapy... - CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbusAlberto L Horenstein
Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
Mol Med 15:76-84. 2009..The presence and characteristics of these ectoenzymes may be exploited to design drugs for wound repair or for applications in tissue transplantation... - CD157 is an important mediator of neutrophil adhesion and migrationAda Funaro
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 19, 10126 Torino, Italy
Blood 104:4269-78. 2004..These neutrophils showed constant defects in adhesion and migration. Our data attribute specific and crucial roles to CD157 in the regulation of innate immunity during inflammation... - Human CD38 and CD16 are functionally dependent and physically associated in natural killer cellsSilvia Deaglio
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, Turin, Italy
Blood 99:2490-8. 2002..This molecule is CD16 in NK cells... - Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cellsLuisella Righi
Department of Genetics, Biology, and Biochemistry, Laboratory of Immunogenetics, University of Torino Medical School, Torino, Italy
Am J Pathol 162:1163-74. 2003..In conclusion, CD31 expression reverts the undifferentiated morphology and aggressive behavior of MDA-MB-231 cells, indicating its active role in the morphogenesis of breast ductal in situ carcinomas... - Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cellsAda Funaro
Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Torino, Italy
BMC Biotechnol 8:85. 2008.... - Functional, structural, and distribution analysis of the chorionic gonadotropin receptor using murine monoclonal antibodiesAda Funaro
Department of Genetics, Biology and Biochemistry and Research Center for Experimental Medicine, University of Torino, Torino 10126, Italy
J Clin Endocrinol Metab 88:5537-46. 2003..This observation suggests that the mAb recognizes an epitope that is included in the domain of the receptor involved in the interaction with the natural ligand... - Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic optionsValentina Audrito
Department of Medical Sciences, University of Turin, School of Medicine, Turin, Italy Human Genetics Foundation HuGeF, Turin, Italy
Cancer Lett 328:27-35. 2013..At the same time, it seeks to hone in on which discrete molecular elements are best suited as targets for treating this still incurable disease... - Contribution of dendritic cells' FcgammaRI and FcgammaRIII to cross-presentation of tumor cells opsonized with the anti-MHC class I monoclonal antibodiesElena Signorino
Laboratory of Tumor Immunology, University of Turin, Turin, Italy
Cancer Biol Ther 6:1932-7. 2007.... - Ectoenzymes and innate immunity: the role of human CD157 in leukocyte traffickingAda Funaro
Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Torino, Italy
Front Biosci 14:929-43. 2009..Indeed, CD157-mediated signals promote cell polarization, regulate chemotaxis induced through the high affinity fMLP receptor and control transendothelial migration... - NAD+-metabolizing ecto-enzymes shape tumor-host interactions: the chronic lymphocytic leukemia modelTiziana Vaisitti
Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
FEBS Lett 585:1514-20. 2011..We have exploited chronic lymphocytic leukemia as a model to test the role of the ecto-enzyme network, starting by analyzing the individual elements that make up the whole picture... - Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor networkValentina Audrito
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Turin, Rome, Italy
Cancer Res 71:4473-83. 2011..These observations suggested the therapeutic potential of nicotinamide, a novel, safe, and inexpensive drug, to be used in addition to chemotherapy for CLL patients with wt p53... - Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserumSilvia Deaglio
Laboratory of Immunogenetics, Department of Genetics, Biology, and Biochemistry, the Experimental Medicine Research Center, University of Turin Medical School, Italy
Blood 100:3782-9. 2002..The tissue distribution pattern, the behavior following exposure to iron-loaded TF, and the features of the disease resulting from TFR-2 inactivation support the hypothesis that TFR-2 contributes to body iron sensing... - CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cellsSilvia Deaglio
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy
Semin Cancer Biol 20:416-23. 2010..In addition to driving the clinical outcome of the disease, CD38 is thus an excellent candidate therapeutic target for a significant subset of CLL patients... - Design and scaleup of downstream processing of monoclonal antibodies for cancer therapy: from research to clinical proof of principleAlberto L Horenstein
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy
J Immunol Methods 275:99-112. 2003..Not less importantly, all the techniques applied are characterized by costs which are affordable to medium-sized laboratories. They represent the basis for implementing immunotherapeutic protocols transferable to clinical medicine... - Purification of clinical-grade monoclonal antibodies by chromatographic methodsAlberto L Horenstein
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School and Research Center for Experimental Medicine (CeRMS, San Giovanni Battista Hospital, Turin, Italy
Methods Mol Biol 308:191-208. 2005 - Different aquaporin-4 expression in glioblastoma multiforme patients with and without seizuresGianluca Isoardo
Unit of Clinical Neurophysiology, Department of Neurosurgery, CTO Hospital, Torino, Italy
Mol Med 18:1147-51. 2012..001). We conclude that reduced expression of cell surface AQP-4 is characteristic of GBM patients without seizures, likely attributable to a posttranslational mechanism... - Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapsePilar Munoz
Departamento de Biología Celular e Immunología, Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Armilla, Spain
Blood 111:3653-64. 2008..These results reveal a new role for CD38 in modulating antigen-mediated T-cell responses during IS formation... - Peripheral blood CD38 expression predicts time to progression in B-cell chronic lymphocytic leukemia after first-line therapy with high-dose chlorambucilFortunato Morabito
Haematologica 87:217-8. 2002.... - CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifsMercedes Zubiaur
Hospital Universitario San Cecilio, Granada 18012, Spain
J Biol Chem 277:13-22. 2002.... - Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemiaJan Dürig
Department of Hematology, Medical Faculty, University of Essen, Germany
Blood 101:2748-55. 2003..05). Our data show that gene expression profiling can help identify B-CLL subtypes with different clinical characteristics. Furthermore, our results suggest a role of translation-associated genes in the pathogenesis of B-CLL... - CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptorPilar Munoz
Instituto de Parasitologia y Biomedicina, Consejo Superior de Investigaciones Cientificas, 18001 Granada, Spain
J Biol Chem 278:50791-802. 2003..Overall, these findings provide the first evidence that CD38 operates in two functionally distinct microdomains of the plasma membrane... - Prognostic significance of combined analysis of ZAP-70 and CD38 in chronic lymphocytic leukemiaGiovanni D'Arena
Hematology Oncology Unit, National Cancer Institute, Fondazione G Pascale, Via Mariano Semmola, Naples, Italy
Am J Hematol 82:787-91. 2007.... - CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytesRoberto Lande
Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, 00161, Rome, Italy
Cell Immunol 220:30-8. 2002..The key element for the receptor mediated signaling is represented by surface density of CD38 on resting monocytes... - CD38 is a marker of human lactealsInger Nina Farstad
Laboratory for Immunohistochemistry and Immunopathology, Rikshospitalet, University of Oslo, Norway
Virchows Arch 441:605-13. 2002..CD38 was not detected on lymphatics in other organs or in rodent lacteals. We propose that CD38 is a novel marker of human small intestinal lymphatic vessels... - Simultaneous expression of CD38 and its ligand CD31 by chronic lymphocytic leukemia B-cells: anecdotal observation or pathogenetic hypothesis for the clinical outcome?Fortunato Morabito
Haematologica 88:354-5. 2003 - A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigensInes Parusel
Institute of Immunology, University Hospital, Hamburg, Germany
Cell Immunol 236:59-65. 2005..Neither of the mAbs reacted with mouse ART4-transfected cells, but NONI-B63 and MIMA-53 did react with a mouse/human ART4 chimera, indicating that the epitope recognized by these mAbs lies in the C-terminal half of the protein... - CD38 is expressed on human mature monocyte-derived dendritic cells and is functionally involved in CD83 expression and IL-12 inductionGiorgio Fedele
Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanit, Rome, Italy
Eur J Immunol 34:1342-50. 2004..Activation via agonistic anti-CD38 mAb induces up-regulation of CD83 expression and IL-12 secretion, whereas disruption of CD38/CD31 interaction inhibits CD83 expression, IL-12 secretion and MDDC-induced allogeneic T cell proliferation... - Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformationFriedrich Koch-Nolte
Institute of Immunology, University Hospital, 20246 Hamburg, Germany
Cell Immunol 236:66-71. 2005..ART1 and ART4 have been assigned the designations: CD296, and CD297, respectively... - TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathwayAlessia Calzolari
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Rome, Italy
J Cell Sci 119:4486-98. 2006..In conclusion, the present study indicates that TfR2 localizes in LDTI microdomains, where it promotes cell signalling, and is exported out of the cells through the exosome pathway, where it acts as an intercellular messenger... - Retinoic acid-induced CD38 antigen as a target for immunotoxin-mediated killing of leukemia cellsKapil Mehta
Department of Bioimmunotherapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Mol Cancer Ther 3:345-52. 2004..Our results suggest that RA combined with anti-CD38-based therapeutic agent may offer exciting opportunities for the treatment of myeloid leukemias despite their multiplicity of genetic and clinical varieties... - Death of T cell precursors in the human thymus: a role for CD38Claudya Tenca
Section of Human Anatomy, Department of Experimental Medicine, University of Genova, 16132 Genova, Italy
Int Immunol 15:1105-16. 2003..In addition, CD28 expression on developing thymocytes also appears to play a role for their selection and it synergizes with CD38 to induce apoptosis of DP thymocytes... - The role of platelet/endothelial cell adhesion molecule 1 (CD31) and CD38 antigens in marrow microenvironmental retention of acute myelogenous leukemia cellsNathalie Gallay
INSERM ESPRI EA3855, Universite Francois Rabelais, Tours, France
Cancer Res 67:8624-32. 2007..Importantly, the excess of CD31 in those samples was associated with a higher peripheral WBC count. These findings indicate that bone marrow retention of AML cells depends on CD31 and CD38 coexpression levels... - CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cellsLoredana Frasca
Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
Blood 107:2392-9. 2006..These findings may lay out the basis to assess the functional role(s) of human CD38 in infections, autoimmune diseases, and neoplastic disorders... - Human CD38 interferes with HIV-1 fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120Andrea Savarino
Laboratory of Immunology, Interdisciplinary Research Center of Autoimmune Diseases, Department of Medical Science, University of Eastern Piedmont, Novara, Italy
FASEB J 17:461-3. 2003..Conversely, a deletion in the V3-like region abrogated the anti-HIV-1 activity of CD38 and its lateral association with CD4. These findings may provide new insights into the early events of HIV-1 fusion and strategies to intervene... - Transferrin receptor 2 protein is not expressed in normal erythroid cellsAlessia Calzolari
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Biochem J 381:629-34. 2004..The implications of this observation for the understanding of the phenotypic features of haemochromatosis due to mutation of the TFR2 gene are discussed... - Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosineChristian Krebs
Institute of Immunology, University Hospital, Martinistrasse 52, D-20246, Hamburg, Germany
Anal Biochem 314:108-15. 2003..The immunoblot 1G4 staining assay can also be used to identify etheno-ADP-ribosylated target proteins. These new assays hold promise for many interesting applications in biochemistry and cell biology... - Radioimmunotherapy in advanced ovarian cancer: is there a role for pre-targeting with (90)Y-biotin?Chiara Grana
Division of Nuclear Medicine, European Institute of Oncology, Milano, Italy
Gynecol Oncol 93:691-8. 2004..Pre-targeting RIT, based on the avidin-biotin system, has been the objective of previous studies performed by our group... - Immunodetection of anti-MAG IgM antibody by cross-reactivity to LA-N-1 neuroblastoma cellsGianluca Isoardo
SOC Neurologia, Ospedale Civile di Asti, 14100 Asti, Italy
J Neuroimmunol 161:78-86. 2005..We report here on the evaluation of the LA-N-1 cell line as an appropriate substrate for the detection of anti-MAG antibody by indirect immunoflourescence... - CD molecules 2005: human cell differentiation moleculesHeddy Zola
Child Health Research Institute, 72 King William Rd, North Adelaide 5006, South Australia, Australia
Blood 106:3123-6. 2005.... - Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effectsGermano Baj
Laboratories of Gynecologic Oncology, University of Eastern Piedmont A. Avogadro, Novara, Italy
Breast Cancer Res Treat 73:61-73. 2002.... - Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cellsAnna Corcione
Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
Int Immunol 14:883-92. 2002..CCR1, CCR2 and CCR4 were detected by flow cytometry on non-GC (i.e. naive and memory) B cells, whereas they were absent (CCR1 and CCR2) or poorly expressed (CCR4) on GC B cells... - IFN-gamma arms human dendritic cells to perform multiple effector functionsLoredana Frasca
Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
J Immunol 180:1471-81. 2008..These data also help understand the dual role exerted by this cytokine as both an inducer and a regulator of inflammation and immune response... - The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virusSonia Molina
INSERM, U632, Hepatic Physiopathology, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
J Hepatol 46:411-9. 2007..The direct implication of low-density lipoprotein receptor (LDLR) in hepatitis C virus (HCV) infection of human hepatocyte has not been demonstrated. Normal primary human hepatocytes infected by serum HCV were used to document this point... - CD molecules 2006--human cell differentiation moleculesHeddy Zola
Child Health Research Institute and Adelaide University Discipline of Paediatrics, 72 King William Road, North Adelaide, South Australia 5006, Australia
J Immunol Methods 319:1-5. 2007..At that meeting the Council, acting as Nomenclature Committee, approved a number of new CD designations and changes to some pre-existing CD designations, which are summarized in this report... - Transferrin receptor 2 is frequently expressed in human cancer cell linesAlessia Calzolari
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Blood Cells Mol Dis 39:82-91. 2007..Furthermore, our studies indicate that, at least in tumor cells, TfR2 expression is modulated by iron through different biochemical mechanisms, whose molecular basis remains to be determined...