M Malatesta

Summary

Affiliation: University of Urbino
Country: Italy

Publications

  1. ncbi Immunocytochemical analysis of the circadian clock protein in mouse hepatocytes
    Manuela Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino, I 61029 Urbino, Italy
    Microsc Res Tech 61:414-8. 2003
  2. ncbi Quantitative ultrastructural changes of hepatocyte constituents in euthermic, hibernating and arousing dormice (Muscardinus avellanarius)
    M Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Via Zeppi, 61029, Urbino, Italy
    Tissue Cell 34:397-405. 2002
  3. ncbi Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Italy
    J Anat 201:409-15. 2002
  4. ncbi Disassembly of nuclear bodies during arousal from hibernation: an in vitro study
    M Malatesta
    Instituto di Istologia ed Analisi di Laboratorio, University of Urbino, Urbino, Italy
    Chromosoma 110:471-7. 2001
  5. ncbi Fine distribution of CLOCK protein in hepatocytes of hibernating dormice
    M Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino, via Zeppi s n, 61029 Urbino, Italy
    Eur J Histochem 47:233-40. 2003
  6. ncbi Ultrastructural and immunocytochemical analyses of opioid treatment effects on PC3 prostatic cancer cells
    Beatrice Baldelli
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, Urbino, Italy
    Microsc Res Tech 64:243-9. 2004
  7. ncbi Fine structural modifications of liver, pancreas and brown adipose tissue mitochondria from hibernating, arousing and euthermic dormice
    M Malatesta
    Institute of Histology and Laboratory Analyses, University of Urbino, Urbino, I 61029, Italy
    Cell Biol Int 25:131-8. 2001
  8. ncbi Nucleoli undergo structural and molecular modifications during hibernation
    M Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino, 61029 Urbino, Italy
    Chromosoma 109:506-13. 2000
  9. ncbi Aging affects the distribution of the circadian CLOCK protein in rat hepatocytes
    Manuela Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino Carlo Bo, Urbino, Italy
    Microsc Res Tech 68:45-50. 2005
  10. ncbi Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean
    M Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, via Zeppi s n, 61029 Urbino, Italy
    Eur J Histochem 49:237-42. 2005

Collaborators

Detail Information

Publications31

  1. ncbi Immunocytochemical analysis of the circadian clock protein in mouse hepatocytes
    Manuela Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino, I 61029 Urbino, Italy
    Microsc Res Tech 61:414-8. 2003
    ..At this time the hepatic transcriptional rate reaches the maximal level, thus suggesting an important role of CLOCK protein in the regulation of liver gene expression...
  2. ncbi Quantitative ultrastructural changes of hepatocyte constituents in euthermic, hibernating and arousing dormice (Muscardinus avellanarius)
    M Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Via Zeppi, 61029, Urbino, Italy
    Tissue Cell 34:397-405. 2002
    ..Such a reduced activity involves profound rearrangement of the euthermic cell structure, which is rapidly resumed upon arousal...
  3. ncbi Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Italy
    J Anat 201:409-15. 2002
    ..In particular, a diet containing significant amount of GM food seems to influence the zymogen synthesis and processing...
  4. ncbi Disassembly of nuclear bodies during arousal from hibernation: an in vitro study
    M Malatesta
    Instituto di Istologia ed Analisi di Laboratorio, University of Urbino, Urbino, Italy
    Chromosoma 110:471-7. 2001
    ....
  5. ncbi Fine distribution of CLOCK protein in hepatocytes of hibernating dormice
    M Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino, via Zeppi s n, 61029 Urbino, Italy
    Eur J Histochem 47:233-40. 2003
    ..Accordingly, in hepatocytes submitted to in vitro conditions mimicking arousal CLOCK protein levels rapidly reach the euthermic values, while amorphous bodies disappear...
  6. ncbi Ultrastructural and immunocytochemical analyses of opioid treatment effects on PC3 prostatic cancer cells
    Beatrice Baldelli
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, Urbino, Italy
    Microsc Res Tech 64:243-9. 2004
    ..Our data suggest that DADLE is able to slow down the synthetic activity of PC3 cells, perhaps interfering with nuclear functions...
  7. ncbi Fine structural modifications of liver, pancreas and brown adipose tissue mitochondria from hibernating, arousing and euthermic dormice
    M Malatesta
    Institute of Histology and Laboratory Analyses, University of Urbino, Urbino, I 61029, Italy
    Cell Biol Int 25:131-8. 2001
    ..These structural modifications are probably related to the changes in cellular energy needs during the euthermia-hibernation-arousal cycle...
  8. ncbi Nucleoli undergo structural and molecular modifications during hibernation
    M Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino, 61029 Urbino, Italy
    Chromosoma 109:506-13. 2000
    ....
  9. ncbi Aging affects the distribution of the circadian CLOCK protein in rat hepatocytes
    Manuela Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino Carlo Bo, Urbino, Italy
    Microsc Res Tech 68:45-50. 2005
    ..This unusual distribution of CLOCK protein during aging could be related to the prolonged diurnal activity of old animals and/or to altered nuclear pathways...
  10. ncbi Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean
    M Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, via Zeppi s n, 61029 Urbino, Italy
    Eur J Histochem 49:237-42. 2005
    ..This suggests that the modifications related to GM soybean are potentially reversible, but also that some modifications are inducible in adult organisms in a short time...
  11. ncbi Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, via Zeppi s n, University of Urbino, Italy
    Cell Struct Funct 27:173-80. 2002
    ..In conclusion, our data suggest that GM soybean intake can influence hepatocyte nuclear features in young and adult mice; however, the mechanisms responsible for such alterations remain unknown...
  12. ncbi Nuclear bodies are usual constituents in tissues of hibernating dormice
    M Malatesta
    Institute of Histology and Laboratory Analyses, University of Urbino, Italy
    Anat Rec 254:389-95. 1999
    ..If they represent storage and/or assembly sites of splicing factors to be rapidly used upon arousal, they could represent a usual structural feature in cells of hibernating species...
  13. ncbi Immunoreactivity, ultrastructural localization, and transcript expression of prostate-specific antigen in human neuroblastoma cell lines
    F Mannello
    Institute of Histology and Laboratory Analysis, Faculty of Sciences, University of Urbino, Italy
    Clin Chem 45:78-84. 1999
    ....
  14. ncbi Histochemical and morpho-metrical study of mouse intestine epithelium after a long term diet containing genetically modified soybean
    S Battistelli
    Department of Biomolecular Sciences, Clinical Biochemistry Section, University of Urbino, Via Ubaldini 7, Urbino PU, Italy
    Eur J Histochem 54:e36. 2010
    ..In particular, the percentage of villous area occupied by acidic and sulpho-mucin granules decreased from controls to GM-fed animals, whereas neutral mucins did not change...
  15. ncbi Cytochemical and immunocytochemical methods for electron microscopic detection of glucose-6-phosphate dehydrogenase in brain areas
    P Ninfali
    Istituto di Chimica Biologica G Fornaini, University of Urbino, Via A Saffi 2, I 61029, Urbino, Italy
    Brain Res Brain Res Protoc 5:115-20. 2000
    ..These protocols are useful to detect peculiar populations of neurons which express high levels of G6PD to sustain processes of neural plasticity in some brain areas...
  16. ncbi Immunoelectron microscope analysis of epidermal growth factor receptor (EGFR) in isolated Mytilus galloprovincialis (Lam.) digestive gland cells: evidence for ligand-induced changes in EGFR intracellular distribution
    L Canesi
    Istituto di Scienze Fisiologiche, Loc Crocicchia, Urbino, Italy
    J Exp Zool 286:690-8. 2000
    ....
  17. ncbi Possible involvement of Pseudomonas fluorescens and Bacillaceae in structural modifications of Tuber borchii fruit bodies
    B Citterio
    Istituto di Scienze Tossicologiche, Igienistiche e Ambientali, , Urbino, Italy
    Can J Microbiol 47:264-8. 2001
    ..Moreover, the presence of P. fluorescens and Bacillaceae on isolated mature spores after decontamination suggests an intimate association between these bacteria and the ascospores...
  18. ncbi Effect of listeriolysin O-loaded erythrocytes on Mycobacterium avium replication within macrophages
    L Rossi
    Institute of Biochemistry G. Fornaini, University of Urbino, Via Saffi, 2, 61029 Urbino (PU, Italy
    J Antimicrob Chemother 53:863-6. 2004
    ..We are confident that the strategy presented could be useful against mycobacteria other than M. avium (such as Mycobacterium tuberculosis and Mycobacterium leprae) by itself or as part of an antimycobacterial treatment...
  19. ncbi Differential distribution of soluble and complexed forms of prostate-specific antigen in cyst fluids of women with gross cystic breast disease
    M Malatesta
    Istituto di Istologia and Analisi di Laboratorio, , , Urbino, Italy
    J Clin Lab Anal 15:81-6. 2001
    ..Our results are consistent with the notion that a prolonged exposure of apocrine breast cells lining the Type I gross cysts to the proteolytic activity of PSA could be involved in the etiopathogenesis of GCBD...
  20. ncbi Glucose-6-phosphate dehydrogenase in small intestine of rabbit: biochemical properties and subcellular localization
    P Ninfali
    Istituto di Chimica Biologica G Fornaini, University of Urbino, Italy
    Acta Histochem 103:287-303. 2001
    ....
  21. ncbi Hibernation as a far-reaching program for the modulation of RNA transcription
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Verona, Italy
    Microsc Res Tech 71:564-72. 2008
    ..Once again natural hibernation appears as a highly programmed hypometabolic state rather than a simple fall of metabolic and physiological functions...
  22. ncbi Effects of ageing on the fine distribution of the circadian CLOCK protein in reticular formation neurons
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, Strada Le Grazie, 8, 37134, Verona, Italy
    Histochem Cell Biol 127:641-7. 2007
    ....
  23. ncbi Influence of temperature on the liver circadian clock in the ruin lizard Podarcis sicula
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, Universita di Verona, Italia
    Microsc Res Tech 70:578-84. 2007
    ....
  24. ncbi The effect of the enkephalin DADLE on transcription does not depend on opioid receptors
    Beatrice Baldelli
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, 61029 Urbino, Italy
    Histochem Cell Biol 126:189-97. 2006
    ..DADLE can, therefore, be envisaged as an extremely promising molecule to be used for inducing a reversible hypometabolic state in various cultured cells, without provoking cell damage or death...
  25. ncbi DADLE induces a reversible hibernation-like state in HeLa cells
    Lorella Vecchio
    Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia Animale, , Piazza Botta 10, 27100, Pavia, Italy
    Histochem Cell Biol 125:193-201. 2006
    ..After recovery, there was a gradual resumption of cell function: transcription and splicing factors had a distribution similar to that of controls; proliferation resumed; nuclear bodies, representing storage sites for RNPs, disappeared...
  26. ncbi Altered RNA structural constituents in aging and vitamin E deficiency
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Urbino, Italy
    Mech Ageing Dev 124:175-81. 2003
    ..Considering the antioxidant action of alpha-tocopherol, our data lend further support to the importance of free radical production and control in the aging process...
  27. ncbi Aging and vitamin E deficiency are responsible for altered RNA pathways
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, Urbino, Italy
    Ann N Y Acad Sci 1019:379-82. 2004
    ..These data document altered RNA pathways in aging and vitamin E deficiency. Considering the antioxidant role of vitamin E, they lend further support to the importance of free radical production and control in the aging process...
  28. ncbi Ultrastructural characterisation of a nuclear domain highly enriched in survival of motor neuron (SMN) protein
    Manuela Malatesta
    Centre of Electron Microscopy, University of Lausanne, 1005 Lausanne, Switzerland
    Exp Cell Res 292:312-21. 2004
    ..Our data reveal a novel SMN/Gemin2 containing nuclear domain and support the idea that it represents the structural counterpart of gems seen in the light microscope...
  29. ncbi Quantification of G6PD in small and large intestine of rat during aging
    Enrica Biagiotti
    Institute of Biochemistry G Fornaini, University of Urbino, Italy
    Acta Histochem 104:225-34. 2002
    ..These data suggest that G6PD activity in epithelium of SI and LI decreases with aging due to the accumulation of significant amounts of enzyme bound to cell organelles, a condition which makes it less active than the soluble enzyme...
  30. ncbi Increased intracellular ionic content is correlated with a decreased perichromatin granule density in old neurons
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, National Institute of Reserach and Care on Aging Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1030:289-96. 2004
    ..In physiological aging, increased ionic strength may lead to age-related DNA dysfunction as well as to alterations in the processing of RNA structural constituents, such as PGs...
  31. ncbi Perichromatin fibrils as early markers of transcriptional alterations
    Marco Biggiogera
    Dipartimento di Biologia Animale, Laboratorio di Biologia Cellulare e Neurobiologia, University of Pavia, and Istituto di Genetica Molecolare del C N R, Piazza Botta 10, 27100 Pavia, Italy
    Differentiation 76:57-65. 2008
    ....