M Malatesta

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. doi Hibernation as a far-reaching program for the modulation of RNA transcription
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Verona, Italy
    Microsc Res Tech 71:564-72. 2008
  2. doi Tracing nanoparticles and photosensitizing molecules at transmission electron microscopy by diaminobenzidine photo-oxidation
    M Malatesta
    Department of Neurological and Movement Sciences Anatomy and Histology Section, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy Electronic address
    Micron 59:44-51. 2014
  3. pmc Simultaneous ultrastructural analysis of fluorochrome-photoconverted diaminobenzidine and gold immunolabelling in cultured cells
    M Malatesta
    Dipartimento di Scienze Neurologiche e del Movimento, Sezione di Anatomia e Istologia, Universita di Verona
    Eur J Histochem 57:e26. 2013
  4. pmc Muscleblind-like1 undergoes ectopic relocation in the nuclei of skeletal muscles in myotonic dystrophy and sarcopenia
    M Malatesta
    Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Sezione di Anatomia e Istologia, Universita di Verona, 37134 Verona, Italy
    Eur J Histochem 57:e15. 2013
  5. doi Human myoblasts from skeletal muscle biopsies: in vitro culture preparations for morphological and cytochemical analyses at light and electron microscopy
    Manuela Malatesta
    Sezione di Anatomia e Istologia, Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, University of Verona, Verona, Italy
    Methods Mol Biol 976:67-79. 2013
  6. pmc Cultured myoblasts from patients affected by myotonic dystrophy type 2 exhibit senescence-related features: ultrastructural evidence
    M Malatesta
    Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Sezione di Anatomia e Istologia, University of Verona, Italy
    Eur J Histochem 55:e26. 2011
  7. pmc Skeletal muscle features in myotonic dystrophy and sarcopenia: do similar nuclear mechanisms lead to skeletal muscle wasting?
    M Malatesta
    Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Sezione di Anatomia e Istologia, Universita degli Studi di Verona, Strada Le Grazie 8, Verona, Italy
    Eur J Histochem 56:e36. 2012
  8. pmc Diaminobenzidine photoconversion is a suitable tool for tracking the intracellular location of fluorescently labelled nanoparticles at transmission electron microscopy
    M Malatesta
    Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Italy
    Eur J Histochem 56:e20. 2012
  9. doi Hepatoma tissue culture (HTC) cells as a model for investigating the effects of low concentrations of herbicide on cell structure and function
    M Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Toxicol In Vitro 22:1853-60. 2008
  10. pmc The cell nuclei of skeletal muscle cells are transcriptionally active in hibernating edible dormice
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Italy
    BMC Cell Biol 10:19. 2009

Collaborators

Detail Information

Publications34

  1. doi Hibernation as a far-reaching program for the modulation of RNA transcription
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Verona, Italy
    Microsc Res Tech 71:564-72. 2008
    ..Once again natural hibernation appears as a highly programmed hypometabolic state rather than a simple fall of metabolic and physiological functions...
  2. doi Tracing nanoparticles and photosensitizing molecules at transmission electron microscopy by diaminobenzidine photo-oxidation
    M Malatesta
    Department of Neurological and Movement Sciences Anatomy and Histology Section, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy Electronic address
    Micron 59:44-51. 2014
    ..In addition, DAB photo-oxidized samples are suitable for the ultrastructural detection of organelle-specific molecules by post-embedding gold immunolabeling. ..
  3. pmc Simultaneous ultrastructural analysis of fluorochrome-photoconverted diaminobenzidine and gold immunolabelling in cultured cells
    M Malatesta
    Dipartimento di Scienze Neurologiche e del Movimento, Sezione di Anatomia e Istologia, Universita di Verona
    Eur J Histochem 57:e26. 2013
    ..This simple and reliable procedure exploits a single sample to simultaneously localise the photoconversion product and a variety of antigens allowing a specific identification of subcellular organelles at the ultrastructural level. ..
  4. pmc Muscleblind-like1 undergoes ectopic relocation in the nuclei of skeletal muscles in myotonic dystrophy and sarcopenia
    M Malatesta
    Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Sezione di Anatomia e Istologia, Universita di Verona, 37134 Verona, Italy
    Eur J Histochem 57:e15. 2013
    ....
  5. doi Human myoblasts from skeletal muscle biopsies: in vitro culture preparations for morphological and cytochemical analyses at light and electron microscopy
    Manuela Malatesta
    Sezione di Anatomia e Istologia, Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, University of Verona, Verona, Italy
    Methods Mol Biol 976:67-79. 2013
    ..In their ultrastructural cytochemical application, the protocols are intended for post-embedding techniques, by which ultrathin sections from a single sample may be used for detecting a wide variety of molecular markers...
  6. pmc Cultured myoblasts from patients affected by myotonic dystrophy type 2 exhibit senescence-related features: ultrastructural evidence
    M Malatesta
    Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Sezione di Anatomia e Istologia, University of Verona, Italy
    Eur J Histochem 55:e26. 2011
    ....
  7. pmc Skeletal muscle features in myotonic dystrophy and sarcopenia: do similar nuclear mechanisms lead to skeletal muscle wasting?
    M Malatesta
    Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Sezione di Anatomia e Istologia, Universita degli Studi di Verona, Strada Le Grazie 8, Verona, Italy
    Eur J Histochem 56:e36. 2012
    ..These results suggest possible common cellular mechanisms responsible for skeletal muscle wasting in sarcopenia and in myotonic dystrophy...
  8. pmc Diaminobenzidine photoconversion is a suitable tool for tracking the intracellular location of fluorescently labelled nanoparticles at transmission electron microscopy
    M Malatesta
    Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Italy
    Eur J Histochem 56:e20. 2012
    ....
  9. doi Hepatoma tissue culture (HTC) cells as a model for investigating the effects of low concentrations of herbicide on cell structure and function
    M Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Toxicol In Vitro 22:1853-60. 2008
    ....
  10. pmc The cell nuclei of skeletal muscle cells are transcriptionally active in hibernating edible dormice
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Italy
    BMC Cell Biol 10:19. 2009
    ..The focus was on cell nuclei and mitochondria, which are highly sensitive markers of changing metabolic rate...
  11. ncbi Nuclei of aged myofibres undergo structural and functional changes suggesting impairment in RNA processing
    M Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Italy
    Eur J Histochem 53:97-106. 2009
    ..This failure likely contributes to the reduced responsiveness of muscle cells to anabolic stimuli in the elderly...
  12. doi Distribution of the epilepsy-related Lgi1 protein in rat cortical neurons
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, Universita di Verona, Verona, Italy
    Histochem Cell Biol 132:505-13. 2009
    ....
  13. pmc Pre-mRNA processing is partially impaired in satellite cell nuclei from aged muscles
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, 37134 Verona, Italy
    J Biomed Biotechnol 2010:410405. 2010
    ..We demonstrated that in satellite cells the RNA pathways undergo alterations during aging, possibly hampering their responsiveness to muscle damage...
  14. doi Immunoelectron microscopic characterization of nucleolus-associated domains during hibernation
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Verona, Italy
    Microsc Res Tech 74:47-53. 2011
    ....
  15. pmc Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ
    M Malatesta
    Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Sezione di Anatomia e Istologia, Universita di Verona, Italy
    Eur J Histochem 54:e44. 2010
    ..amp;nbsp;..
  16. doi Physical training modulates structural and functional features of cell nuclei in type II myofibers of old mice
    Manuela Malatesta
    Department of Neurological, Neuropsychological, Morphological and Motor Sciences, Anatomy and Histology Section, University of Verona, Verona, Italy
    Rejuvenation Res 14:543-52. 2011
    ....
  17. doi A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    Histochem Cell Biol 130:967-77. 2008
    ....
  18. ncbi Effects of ageing on the fine distribution of the circadian CLOCK protein in reticular formation neurons
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, Strada Le Grazie, 8, 37134, Verona, Italy
    Histochem Cell Biol 127:641-7. 2007
    ....
  19. doi Perichromatin fibrils accumulation in hepatocyte nuclei reveals alterations of pre-mRNA processing during aging
    Manuela Malatesta
    1 Department of Morphological and Biomedical Sciences, Anatomy and Histology Section, University of Verona, Verona, Italy
    DNA Cell Biol 29:49-57. 2010
    ..Therefore, our data indicate both a decrease in pre-mRNA transcription and a slow down of PF processing and transport during aging...
  20. ncbi Ultrastructure of the adrenal cortex of hibernating, arousing, and euthermic dormouse, Muscardinus avellanarius
    C Zancanaro
    Institute of Anatomy and Histology, University of Verona, Italy
    Anat Rec 249:359-64. 1997
    ..Very limited information is available on the fine structure of the gland during hibernation and on the periodical arousal from hibernation...
  21. ncbi Influence of temperature on the liver circadian clock in the ruin lizard Podarcis sicula
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, Universita di Verona, Italia
    Microsc Res Tech 70:578-84. 2007
    ....
  22. pmc Subcellular distribution of key enzymes of lipid metabolism during the euthermia-hibernation-arousal cycle
    Anna Suozzi
    Dipartimento di Scienze Morfologico Biomediche, University of Verona, Italy
    J Anat 214:956-62. 2009
    ....
  23. ncbi Immunocytochemical analysis of the circadian clock protein in mouse hepatocytes
    Manuela Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino, I 61029 Urbino, Italy
    Microsc Res Tech 61:414-8. 2003
    ..At this time the hepatic transcriptional rate reaches the maximal level, thus suggesting an important role of CLOCK protein in the regulation of liver gene expression...
  24. ncbi Aging and vitamin E deficiency are responsible for altered RNA pathways
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, Urbino, Italy
    Ann N Y Acad Sci 1019:379-82. 2004
    ..These data document altered RNA pathways in aging and vitamin E deficiency. Considering the antioxidant role of vitamin E, they lend further support to the importance of free radical production and control in the aging process...
  25. ncbi Perichromatin fibrils as early markers of transcriptional alterations
    Marco Biggiogera
    Dipartimento di Biologia Animale, Laboratorio di Biologia Cellulare e Neurobiologia, University of Pavia, and Istituto di Genetica Molecolare del C N R, Piazza Botta 10, 27100 Pavia, Italy
    Differentiation 76:57-65. 2008
    ....
  26. ncbi Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, via Zeppi s n, University of Urbino, Italy
    Cell Struct Funct 27:173-80. 2002
    ..In conclusion, our data suggest that GM soybean intake can influence hepatocyte nuclear features in young and adult mice; however, the mechanisms responsible for such alterations remain unknown...
  27. ncbi Aging affects the distribution of the circadian CLOCK protein in rat hepatocytes
    Manuela Malatesta
    Istituto di Istologia ed Analisi di Laboratorio, University of Urbino Carlo Bo, Urbino, Italy
    Microsc Res Tech 68:45-50. 2005
    ..This unusual distribution of CLOCK protein during aging could be related to the prolonged diurnal activity of old animals and/or to altered nuclear pathways...
  28. ncbi Altered RNA structural constituents in aging and vitamin E deficiency
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Urbino, Italy
    Mech Ageing Dev 124:175-81. 2003
    ..Considering the antioxidant action of alpha-tocopherol, our data lend further support to the importance of free radical production and control in the aging process...
  29. pmc Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean
    Manuela Malatesta
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Italy
    J Anat 201:409-15. 2002
    ..In particular, a diet containing significant amount of GM food seems to influence the zymogen synthesis and processing...
  30. ncbi Quantification of G6PD in small and large intestine of rat during aging
    Enrica Biagiotti
    Institute of Biochemistry G Fornaini, University of Urbino, Italy
    Acta Histochem 104:225-34. 2002
    ..These data suggest that G6PD activity in epithelium of SI and LI decreases with aging due to the accumulation of significant amounts of enzyme bound to cell organelles, a condition which makes it less active than the soluble enzyme...
  31. ncbi Ultrastructural characterisation of a nuclear domain highly enriched in survival of motor neuron (SMN) protein
    Manuela Malatesta
    Centre of Electron Microscopy, University of Lausanne, 1005 Lausanne, Switzerland
    Exp Cell Res 292:312-21. 2004
    ..Our data reveal a novel SMN/Gemin2 containing nuclear domain and support the idea that it represents the structural counterpart of gems seen in the light microscope...
  32. ncbi Increased intracellular ionic content is correlated with a decreased perichromatin granule density in old neurons
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, National Institute of Reserach and Care on Aging Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1030:289-96. 2004
    ..In physiological aging, increased ionic strength may lead to age-related DNA dysfunction as well as to alterations in the processing of RNA structural constituents, such as PGs...
  33. ncbi The effect of the enkephalin DADLE on transcription does not depend on opioid receptors
    Beatrice Baldelli
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, 61029 Urbino, Italy
    Histochem Cell Biol 126:189-97. 2006
    ..DADLE can, therefore, be envisaged as an extremely promising molecule to be used for inducing a reversible hypometabolic state in various cultured cells, without provoking cell damage or death...
  34. ncbi Ultrastructural and immunocytochemical analyses of opioid treatment effects on PC3 prostatic cancer cells
    Beatrice Baldelli
    Istituto di Istologia e Analisi di Laboratorio, University of Urbino Carlo Bo, Urbino, Italy
    Microsc Res Tech 64:243-9. 2004
    ..Our data suggest that DADLE is able to slow down the synthetic activity of PC3 cells, perhaps interfering with nuclear functions...