Mariano Malaguarnera

Summary

Affiliation: University of Catania
Country: Italy

Publications

  1. ncbi request reprint Efficacy of human recombinant erythropoietin plus IFN-alpha in patients affected by chronic hepatitis C
    Ignazio Di Fazio
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Italy
    J Interferon Cytokine Res 24:594-9. 2004
  2. ncbi request reprint Probiotics in the gastrointestinal diseases of the elderly
    G Malaguarnera
    Department of Microbiology, University of Catania, Catania, Italy
    J Nutr Health Aging 16:402-10. 2012
  3. doi request reprint Carnitine derivatives: clinical usefulness
    Mariano Malaguarnera
    Research Centre The Great Senescence, University of Catania, Catania, Italy
    Curr Opin Gastroenterol 28:166-76. 2012
  4. ncbi request reprint Decrease of serum carnitine levels in patients with or without gastrointestinal cancer cachexia
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Cannizzaro Hospital, Catania, Italy
    World J Gastroenterol 12:4541-5. 2006
  5. ncbi request reprint Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial
    Mariano Malaguarnera
    Dipartimento di Scienze della Senescenza, Urologiche e Neurologiche, Universita di Catania, Via Messina 829, 95128, Catania, Italia
    Dig Dis Sci 51:2242-7. 2006
  6. ncbi request reprint Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Viale Andrea Doria 69, 95126, Catania, Italy
    Dig Dis Sci 52:3259-65. 2007
  7. ncbi request reprint A single dose of rasburicase in elderly patients with hyperuricaemia reduces serum uric acid levels and improves renal function
    Mariano Malaguarnera
    Department of Senescence, University of Catania, Urological and Neurological Sciences, Ospedale Cannizzaro, Catania, Italy
    Expert Opin Pharmacother 10:737-42. 2009
  8. ncbi request reprint L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial
    Mariano Malaguarnera
    Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania, Italy
    Am J Clin Nutr 86:1738-44. 2007
  9. doi request reprint Acetyl-L-carnitine treatment in minimal hepatic encephalopathy
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Via Messina 829, 95125, Catania, Italy
    Dig Dis Sci 53:3018-25. 2008
  10. doi request reprint Sexual dysfunction in chronic hepatitis C virus patients treated with interferon alpha and ribavirin
    Mariano Malaguarnera
    Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania, Italy
    J Interferon Cytokine Res 28:603-9. 2008

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Efficacy of human recombinant erythropoietin plus IFN-alpha in patients affected by chronic hepatitis C
    Ignazio Di Fazio
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Italy
    J Interferon Cytokine Res 24:594-9. 2004
    ..Our study confirms the important role played by iron in the response to IFN treatment, suggesting that the use of rHuEPO induces a better response to IFN in patients with chronic hepatitis C by activation of erythropoiesis...
  2. ncbi request reprint Probiotics in the gastrointestinal diseases of the elderly
    G Malaguarnera
    Department of Microbiology, University of Catania, Catania, Italy
    J Nutr Health Aging 16:402-10. 2012
    ....
  3. doi request reprint Carnitine derivatives: clinical usefulness
    Mariano Malaguarnera
    Research Centre The Great Senescence, University of Catania, Catania, Italy
    Curr Opin Gastroenterol 28:166-76. 2012
    ..Carnitine and its derivatives are natural substances involved in both carbohydrate and lipid metabolism. This review summarizes the recent progress in the field in relation to the molecular mechanisms...
  4. ncbi request reprint Decrease of serum carnitine levels in patients with or without gastrointestinal cancer cachexia
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Cannizzaro Hospital, Catania, Italy
    World J Gastroenterol 12:4541-5. 2006
    ..To evaluate the levels of serum carnitine in patients with cancer in digestive organs and to compare them with other cancers in order to provide new insights into the mechanisms of cachexia...
  5. ncbi request reprint Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial
    Mariano Malaguarnera
    Dipartimento di Scienze della Senescenza, Urologiche e Neurologiche, Universita di Catania, Via Messina 829, 95128, Catania, Italia
    Dig Dis Sci 51:2242-7. 2006
    ..No side effects were observed in our study series. Our study demonstrates that LAC administration improved neurological and biohumoral symptoms in selective cirrhotic patients with hepatic coma...
  6. ncbi request reprint Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Viale Andrea Doria 69, 95126, Catania, Italy
    Dig Dis Sci 52:3259-65. 2007
    ..000). We conclude that the improvement in biochemical and neuropsychological tests of the group treated with Bifidobacterium longum+FOS are interesting and merit further, close examination...
  7. ncbi request reprint A single dose of rasburicase in elderly patients with hyperuricaemia reduces serum uric acid levels and improves renal function
    Mariano Malaguarnera
    Department of Senescence, University of Catania, Urological and Neurological Sciences, Ospedale Cannizzaro, Catania, Italy
    Expert Opin Pharmacother 10:737-42. 2009
    ..Our purpose was to evaluate the reduction of serum uric acid and the improvement in renal function...
  8. ncbi request reprint L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial
    Mariano Malaguarnera
    Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania, Italy
    Am J Clin Nutr 86:1738-44. 2007
    ..Centenarians are characterized by weakness, decreasing mental health, impaired mobility, and poor endurance. L-Carnitine is an important contributor to cellular energy metabolism...
  9. doi request reprint Acetyl-L-carnitine treatment in minimal hepatic encephalopathy
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Via Messina 829, 95125, Catania, Italy
    Dig Dis Sci 53:3018-25. 2008
    ..The benefits of ALC in comparison with placebo are demonstrated in greater reductions in serum ammonia levels, as well as in improvements of neuropsychological functioning...
  10. doi request reprint Sexual dysfunction in chronic hepatitis C virus patients treated with interferon alpha and ribavirin
    Mariano Malaguarnera
    Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania, Italy
    J Interferon Cytokine Res 28:603-9. 2008
    ..Our study provided some more information in quantification and qualification of sexual disturbances related to IFN plus Ribavirin administration in the treatment of chronic hepatitis C...
  11. doi request reprint L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Catania, Italy
    Am J Clin Nutr 89:71-6. 2009
    ..Patients with type 2 diabetes are under high oxidative stress, and levels of hyperglycemia correlate strongly with levels of LDL oxidation. Carnitine favorably modulates oxidative stress...
  12. doi request reprint Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: a randomized and controlled double blind study
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Italy
    Eur J Gastroenterol Hepatol 21:762-70. 2009
    ..The aim of this work has been to evaluate the efficacy of the LAC and branched chain amino acids (BCAA) versus BCAA, administered in intravenous infusion, in patients with cirrhotic hepatic coma...
  13. doi request reprint Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, 829 95125 Catania, Italy
    Metabolism 58:1618-23. 2009
    ..001) and HDL increased (0.2 vs 0.11 mmol/L, P < .001). We observed that patients treated with carnitine and simvastatin showed a reduction in small-sized LDL proportion and an increase in LDL particle size...
  14. doi request reprint Bifidobacterium combined with fructo-oligosaccharide versus lactulose in the treatment of patients with hepatic encephalopathy
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Catania 95120, Italy
    Eur J Gastroenterol Hepatol 22:199-206. 2010
    ..Hepatic encephalopathy (HE) is a reversible neuropsychiatric syndrome in patients with liver disease. It was suggested that Bifidobacterium+fructo-oligosaccharides (FOS) may decrease blood and brain ammonia levels...
  15. doi request reprint L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis--a randomized and controlled clinical trial
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Catania, Italy
    Am J Gastroenterol 105:1338-45. 2010
    ..The aim of this study was to evaluate the effects of L-carnitine's supplementation on regression of NASH...
  16. doi request reprint Serum markers of hepatocellular carcinoma
    Giulia Malaguarnera
    Department of Biomedical Science, University of Catania, Via Androne 83, 95124, Catania, Italy
    Dig Dis Sci 55:2744-55. 2010
    ..The hepatocellular carcinoma is one of the most common malignant tumors and carries a poor survival rate. The management of patients at risk for developing HCC remains intricate...
  17. doi request reprint Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Ospedale Cannizzaro, Catania, Italy
    Scand J Gastroenterol 46:750-9. 2011
    ..Acetyl-L-carnitine (ALC) has been shown to be useful in improving blood ammonia and cognitive functions in cirrhotic patients with MHE...
  18. ncbi request reprint Effects of L-carnitine in patients with hepatic encephalopathy
    Mariano Malaguarnera
    Ospedale Cannizzaro, Via Messina, 829 95125 Catania, Italy
    World J Gastroenterol 11:7197-202. 2005
    ..To evaluate the influence of L-carnitine on mental conditions and ammonia effects on patients with hepatic encephalopathy (HE)...
  19. ncbi request reprint Interleukin-2 plus ribavirin versus interferon-alpha-2b plus ribavirin in patients with chronic hepatitis C who did not respond to previous interferon-alpha-2b treatment
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Cannizzaro Hospital, Via Messina 829, 95126 Catania, Italy
    BioDrugs 18:407-13. 2004
    ....
  20. doi request reprint The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-α 2b plus ribavirin
    Michele Malaguarnera
    Research Center The Great Senescence, University of Catania, Catania, Italy
    J Interferon Cytokine Res 31:653-9. 2011
    ..This, in turn, may increase the percentage of patients achieving a sustained virological response...
  21. ncbi request reprint Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease
    Mariano Malaguarnera
    Department of Internal Medicine, University of Catania, Catania, Italy
    Clin Chem Lab Med 42:1032-5. 2004
    ..New therapeutic strategies are necessary, considering that available pharmaceutical forms of vitamin B12 are not utilized by neurons in oxidative stress conditions...
  22. doi request reprint Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus
    Fabio Galvano
    University of Catania, Department of Biological Chemistry, Medical Chemistry and Molecular Biology, Viale A Doria 6, 95125 Catania, Italy
    Expert Opin Pharmacother 10:1875-82. 2009
    ..The aim of the present study was to compare the effects of simvastatin and L-carnitine coadministration versus simvastatin monotherapy on lipid profile, lipoprotein(a) (Lp(a)) and apoprotein(a) (Apo(a)) levels in type II diabetic patients...
  23. pmc L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin
    Michele Malaguarnera
    Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Viale Messina 829, Catania, Italy
    World J Gastroenterol 17:4414-20. 2011
    ..To evaluate the efficacy of L-carnitine on alleviating anemia, thrombocytopenia and leukopenia, and minimizing dose reductions in patients with chronic hepatitis C virus (HCV) in treatment with Interferon α (IFN-α) plus ribavirin...
  24. ncbi request reprint L-carnitine treatment reduces steatosis in patients with chronic hepatitis C treated with alpha-interferon and ribavirin
    Marcello Romano
    Department of Senescence, Urological And Neurological Sciences Ospedale Cannizzaro, Viale Messina, 829 95125 Catania, Italy
    Dig Dis Sci 53:1114-21. 2008
    ..Interferon alpha exerts both antiviral and immunomodulating actions, and influences on lipid metabolism. The aim of our study was to test whether L-carnitine reduces steatosis in patients treated with interferon and ribavirin...
  25. doi request reprint Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study
    Michele Malaguarnera
    Department of Biological Chemistry, Medical Chemistry, and Molecular Biology, University of Catania, Italy
    Am J Clin Nutr 93:799-808. 2011
    ..Fatigue is frequently reported in hepatic encephalopathy (HE) and may be related to hyperammonemia. Acetyl-L-carnitine (ALC) offers neuroprotective benefits and improves mitochondrial energetics and function...
  26. ncbi request reprint L-Carnitine in the treatment of mild or moderate hepatic encephalopathy
    Mariano Malaguarnera
    Dipartimento di Scienze della Senescenza, Urologiche e Neurologiche, Universita degli Studi di Catania, Italia
    Dig Dis 21:271-5. 2003
    ..A significant therapeutic effect of LC was also observed in the NCT-A, which is an accepted and reliable psychometric test for the assessment of mental function in cirrhotic patients with HE...
  27. doi request reprint A combination of glycosylated hemoglobin, impaired fasting glucose and waist circumference is effective in screening for individuals at risk for future type 2 diabetes
    Massimo Motta
    Department of Aging Sciences, Research Center The Extreme Senescence, University of Catania, Cannizzaro Hospital, Via Messina 829, I 95124 Catania, Italy
    Arch Gerontol Geriatr 50:105-9. 2010
    ....
  28. ncbi request reprint Intravenous immunoglobulin plus interferon-alpha in autoimmune hepatitis C
    Mariano Malaguarnera
    Institute of Internal Medicine and Geriatrics, University of Catania, Italy
    BioDrugs 18:63-70. 2004
    ..To evaluate the possible role of intravenous immunoglobulins (IVIg) in the response of patients treated with IFNalpha, we administered IVIg plus IFNalpha and compared the results with a group of patients treated with IFNalpha alone...
  29. ncbi request reprint An evaluation of efficacy and safety of reboxetine in elderly patients affected by "retarded" post-stroke depression. A random, placebo-controlled study
    Liborio Rampello
    Department of Neurosciences, University of Catania, Azienda Policlinico Neurologia, Via S Sofia 78, Catania I 95125, Italy
    Arch Gerontol Geriatr 40:275-85. 2005
    ..We conclude that reboxetine is well tolerated and may be a useful therapeutic option in PSD patients with "retarded" depression...
  30. ncbi request reprint Evaluation of the prophylactic efficacy of amitriptyline and citalopram, alone or in combination, in patients with comorbidity of depression, migraine, and tension-type headache
    Liborio Rampello
    Department of Neurosciences, University of Catania, Catania, Italy
    Neuropsychobiology 50:322-8. 2004
    ..The results indicate that a combined therapy with amitriptyline and citalopram may be particularly beneficial for patients with TTH, migraine and comorbid depression that do not respond to monotherapy...
  31. doi request reprint The metabolic syndrome (MS) in the elderly: considerations on the diagnostic criteria of the International Diabetes Federation (IDF) and some proposed modifications
    Massimo Motta
    Research Center The Great Senescence, University of Catania, Cannizzaro Hospital, Via Messina 829, I 95126 Catania, Italy
    Arch Gerontol Geriatr 48:380-4. 2009
    ..Our conclusion is that it seems to be necessary to verify the validity of our proposed criteria on wider long-term epidemiological studies...
  32. ncbi request reprint Value and significance of new diagnostic criteria of diabetes mellitus in older people
    Massimo Motta
    Department of Senescence Sciences, University of Catania, Cannizzaro Hospital, Via Messina 829, I 95124 Catania, Italy
    Arch Gerontol Geriatr 45:103-8. 2007
    ..In conclusion, in elderly subjects with FPG of 126-140mg/dl, the diagnosis of diabetes is not stable and requires further confirmation...
  33. ncbi request reprint Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer's disease and vascular dementia
    Lucia Malaguarnera
    Department of Biomedical Sciences, University of Catania, Italy
    Neuropathology 26:307-12. 2006
    ..Moreover, as different modifications were detected in the patients affected by AD and VaD, we propose that IL-18 and TGF-beta1 plasma levels might represent possible differential biomarkers...
  34. ncbi request reprint Insulin-resistance (IR) in older age
    Massimo Motta
    Department of Aging Sciences, Urology and Neurology, University of Catania, Cannizzaro Hospital, Via Messina 829, I 95124 Catania, Italy
    Arch Gerontol Geriatr 46:203-9. 2008
    ..The results seem to confirm the possibility that the normoglycemic elderly subjects having a compensatory insulin hypersecretion against the IR, may develop a type 2 diabetes or a metabolic syndrome...
  35. pmc Rosuvastatin reduces nonalcoholic fatty liver disease in patients with chronic hepatitis C treated with α-interferon and ribavirin: Rosuvastatin reduces NAFLD in HCV patients
    Michele Malaguarnera
    Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy
    Hepat Mon 11:92-8. 2011
    ..Interferon and ribavirin combination therapy is the standard treatment for chronic hepatitis C, but if present, NAFLD can reduce the virological response to anti-HCV therapies...
  36. doi request reprint The significance of apolipoprotein-B (Apo-B) in the elderly as a predictive factor of cardio-cerebrovascular complications
    Massimo Motta
    Department of Longevity Sciences, Urology and Neurology, University of Catania, Cannizzaro Hospital, Via Messina 829, I 95124 Catania, Italy
    Arch Gerontol Geriatr 49:162-4. 2009
    ..However, it cannot be considered as an independent factor of preventive diagnosis of the non-fatal cardio-cerebrovascular complications...
  37. ncbi request reprint A review on the actual trends of insulin treatment in elderly with diabetes
    Massimo Motta
    Department of Aging Sciences, Research Centre The Extreme Senescence, University of Catania, Cannizzaro Hospital, Via Messina 829, I 95124 Catania, Italy
    Arch Gerontol Geriatr 47:151-61. 2008
    ..A better compliance can be obtained, being a fundamental aspect in the elderly diabetics, and a reduction of the number and severity of the hypoglycemia, which are the most important aspects in the elderly diabetes...
  38. doi request reprint Rhabdomyolysis induced by rosuvastatin and sildenafil
    Giovanni Pennisi
    Department of Neurosciences, University of Catania, Catania, Italy and Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania, Italy
    South Med J 103:1052-4. 2010
    ..Several days after interruption of therapy, muscle pain and penile erection disappeared. This case demonstrates the interaction of sildenafil with rosuvastatin might result in myopathy...
  39. ncbi request reprint L-carnitine decreases severity and type of fatigue induced by interferon-alpha in the treatment of patients with hepatitis C
    Sergio Neri
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Catania, Italy
    Neuropsychobiology 47:94-7. 2003
    ..Fatigue is a common complaint in patients with liver disease. The aim of our study was to evaluate the efficacy of carnitine on IFN-induced fatigue in subjects with chronic hepatitis C...
  40. doi request reprint Molecular mechanisms involved in NAFLD progression
    Mariano Malaguarnera
    Department of Internal Medicine, University of Catania, Catania, Italy
    J Mol Med (Berl) 87:679-95. 2009
    ..This review aims to assess the potential molecular mediators initiating and supporting the progression of NASH to establish precocious diagnosis and to plan more specific treatment for this disease...
  41. ncbi request reprint New possibilities of treatment for panic attacks in elderly patients: escitalopram versus citalopram
    Liborio Rampello
    Department of Neurosciences, University of Catania, Italy
    J Clin Psychopharmacol 26:67-70. 2006
    ..Here, we compare the efficacy and safety of citalopram, with its S-enantiomer escitalopram at half dosage as to citalopram, in elderly patients who have panic attacks...
  42. ncbi request reprint Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue
    Giovanni Pistone
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Catania, Italy
    Drugs Aging 20:761-7. 2003
    ..Levocarnitine is an important contributor to cellular energy metabolism. This study aims to evaluate the effects of levocarnitine supplementation on body composition, lipid profile and fatigue in elderly subjects with rapid muscle fatigue...
  43. ncbi request reprint Prediction of the response to citalopram and reboxetine in post-stroke depressed patients
    Liborio Rampello
    Department of Neurosciences, Neurologia, Azienda Policlinico, University of Catania, Via S Sofia 78, 95123 Catania, Italy
    Psychopharmacology (Berl) 173:73-8. 2004
    ....
  44. pmc Toxic hepatitis in occupational exposure to solvents
    Giulia Malaguarnera
    Research Centre The Great Senescence, University of Catania, 95100 Catania, Italy
    World J Gastroenterol 18:2756-66. 2012
    ..The health impact of exposure to solvents in the workplace remains an interesting and worrying question for professional health work...
  45. doi request reprint The role of immunity in elderly cancer
    Lucia Malaguarnera
    Department of Biomedical Sciences, University of Catania, Italy
    Crit Rev Oncol Hematol 74:40-60. 2010
    ..Here, we summarize the knowledge on the major changes in the immune system associated with aging in primary lymphoid organs as well as a description of molecular mechanisms, and the impact on cancer development...
  46. ncbi request reprint Elevated plasma total homocysteine in centenarians
    Mariano Malaguarnera
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Catania, Italy
    Clin Chem Lab Med 42:307-10. 2004
    ..On the other hand, it can by hypothesized that good vitamin intake is essential to live over 100 years...
  47. ncbi request reprint Chitotriosidase and inflammatory mediator levels in Alzheimer's disease and cerebrovascular dementia
    Michelino Di Rosa
    Department of Biomedical Sciences, University of Catania, Italy
    Eur J Neurosci 23:2648-56. 2006
    ..In addition, the present findings suggest that ChT could also play a crucial role in pathological conditions such as CvD in which the inflammatory process is activated...
  48. doi request reprint Human chitotriosidase polymorphism is associated with human longevity in Mediterranean nonagenarians and centenarians
    Lucia Malaguarnera
    Department of Biomedical Science, University of Catania, Via Androne 83, Catania, Italy
    J Hum Genet 55:8-12. 2010
    ..These data indicate that the heterozygosis for a 24-bp duplication in the CHIT-1 gene could have a protective effect in human longevity...
  49. ncbi request reprint Plasma levels of interleukin-12 (IL-12), interleukin-18 (IL-18) and transforming growth factor beta (TGF-beta) in Plasmodium falciparum malaria
    Lucia Malaguarnera
    Department of Biomedical Sciences, University of Catania, Italy
    Eur Cytokine Netw 13:425-30. 2002
    ..This finding suggests that fine mechanisms regulate the interaction between IL-12, IL-18 and TGF-beta in the immune response to Plasmodium falciparum...
  50. doi request reprint Rasburicase for the treatment of tumor lysis in hematological malignancies
    Giulia Malaguarnera
    Department of Internal Medicine and Systemic Pathologies, Ospedale Cannizzaro, Viale Messina, 829 95125 Catania, Italy
    Expert Rev Hematol 5:27-38. 2012
    ..Rasburicase is well tolerated and was approved in the EU and in the USA for the management of acute hyperuricemia...
  51. ncbi request reprint The chromogranin-A (CgA) in prostate cancer
    Salvatore Ranno
    Department of Senescence, Urological and Neurological Sciences, University of Catania, Cannizzaro Hospital, Via Messina 829, I 95126 Catania, Italy
    Arch Gerontol Geriatr 43:117-26. 2006
    ..These results support the concept that serum CgA level determination before treatment is a potential prognostic factor for prostate cancer...
  52. ncbi request reprint Serum markers of cutaneous melanoma
    Rosario Perrotta
    Department of Plastic Surgery, University of Catania, Via Messina 829, 95126 Catania, Italy
    Front Biosci (Elite Ed) 2:1115-22. 2010
    ..Tenascin-c, Hyaluronan, Laminin-1 and type VI Collagen are involved in melanoma development and extracellular matrix remodelling during melanoma progression...
  53. ncbi request reprint Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients
    Lucia Malaguarnera
    Department of Biomedical Sciences, University of Catania, Via E De Amicis, 24, 95039 Trecastagni Catania, Italy
    J Hepatol 42:585-91. 2005
    ..We evaluated the relationship between lipid peroxidation and other oxidative stress biomarkers with changes in expression of heme oxygenase-1 (HO-1) in human hepatic steatosis ranging from simple steatosis to NASH...
  54. pmc Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout
    Lisa Cammalleri
    Dept of Senescence, Urological and Neurological Sciences, University of Catania, Catania, Italy
    Int J Med Sci 4:83-93. 2007
    ..A large body of evidence confirms the efficacy and safety of rasburicase, even in comparison to the standard drugs used in the aforementioned pathologies...
  55. ncbi request reprint Cardio-cerebrovascular complications in elderly with diabetes
    Massimo Motta
    Department of Longevity Sciences, Urology and Neurology, University of Catania, Cannizzaro Hospital, Via Messina, 829, I 95124 Catania, Italy
    Arch Gerontol Geriatr 44:261-9. 2007
    ..The subjects affected by both MI and S displayed the worst index of survival in all the three categories considered, therefore, it can be stated that such an association is a determinant factor of mortality...
  56. ncbi request reprint [Thyroid diseases in elderly patients]
    Mario Costanzo
    Universita degli Studi di Catania, Dipartimento Scienze Chirurgiche, Trapianti d Organo e Tecnologie avanzate, Unità Operativa Clinicizzata di Endocrinochirurgia P O U S Luigi S Currò
    Ann Ital Chir 79:447-50. 2008
    ..To evaluate the differences about incidence, kind and clinical features of thyroid diseases in young and elderly patients...
  57. ncbi request reprint Malignant melanoma of nasal cavity: case report and review of the literature
    Mariano Malaguarnera
    Institute of Internal Medicine and Geriatrics, University of Catania, Italy
    Cancer Biother Radiopharm 17:29-34. 2002
  58. pmc Neurotoxicity of acrylamide in exposed workers
    Manuela Pennisi
    Department of Chemistry, University of Catania, Catania 95123, Italy
    Int J Environ Res Public Health 10:3843-54. 2013
    ..Despite all the amount of work which have being carried out on this topic more studies are necessary to fully understand the pathogenetic mechanisms, in order to propose suitable therapies. ..
  59. doi request reprint Prevalence of cardiovascular pathologies in elderly population living in an industrialized area, compared to a control population residing in a rural area
    Antonino Santangelo
    Cattedra di Geriatria, University of Catania c o P O, Cannizzaro Hospital, Via Messina 829, I 95129 Catania, Italy
    Arch Gerontol Geriatr 55:702-5. 2012
    ....
  60. doi request reprint Stabbing headache in patients with autoimmune disorders
    Liborio Rampello
    Department of Neurosciences, University of Catania, 95123 Catania, Italy
    Clin Neurol Neurosurg 114:751-3. 2012
    ..We speculate that stabbing headache may develop as a result of neuroinflammation and, at least in some cases, may be an epiphenomenon of focal demyelinating lesions of the upper or lower brain stem...
  61. doi request reprint Non-melanoma skin cancers in elderly patients
    Rosario Emanuele Perrotta
    Department of Plastic Surgery, University of Catania, Via Messina 829, Catania, Italy
    Crit Rev Oncol Hematol 80:474-80. 2011
    ..The importance of the immune system and its alteration in the genesis of non-melanoma skin cancers is fundamental for the creation of a new therapeutic and less invasive approach...
  62. ncbi request reprint Oxidized LDL antibodies (OLAB) in patients with beta-thalassemia major
    Patrizia Brizzi
    Department of Internal Medicine, University of Sassari, Sassari, Italy
    J Atheroscler Thromb 9:139-44. 2002
    ....
  63. pmc Myopathy with concurrent tadalafil and simvastatin
    Maria Pia Gargante
    Department of Senescence, Urological And Neurological Sciences Ospedale Cannizzaro, Viale Messina, 95125 Catania, Italy
    Case Report Med 2009:378287. 2009
    ..This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system...
  64. ncbi request reprint Increased levels of interleukin-12 in Plasmodium falciparum malaria: correlation with the severity of disease
    Lucia Malaguarnera
    Department of Biomedical Sciences, University of Catania, Italy
    Parasite Immunol 24:387-9. 2002
    ..6 +/- 18.3 pg/ml) in patients who suffered less severely from the disease. In contrast, the levels of IL-12 were found to be lower (13.1 +/- 7.11 pg/ml) in patients who suffered more severely from the disease...
  65. ncbi request reprint Tumor lysis syndrome in elderly
    Vitalinda Pumo
    Department of Longevity Sciences, Urology and Neurology University of Catania, Cannizzaro Hospital, Via Messina 829, I 95126 Catania, Italy
    Crit Rev Oncol Hematol 64:31-42. 2007
    ....
  66. ncbi request reprint The management of tumor lysis syndrome
    Elvira Rampello
    Department of Senescence, Urological and Neurological Sciences, Catania University, Catania, Italy
    Nat Clin Pract Oncol 3:438-47. 2006
    ..Hemodialysis should be considered for every patient with excessively elevated uric acid, phosphate and/or potassium and in those patients with acute renal failure to control urinary volume and manage uremia...
  67. doi request reprint Efficacy and limits of sildenafil citrate in patients with arterial erectile dysfunction: role of peripheral arterial disease and cardiovascular comorbidities
    Enzo Vicari
    Department of Biomedical Sciences, University of Catania, Catania 95123, Italy
    Asian J Androl 10:847-53. 2008
    ....
  68. ncbi request reprint Radioisotopic assessment of gastric emptying of solids in elderly subjects
    Alfio Brogna
    Department of Internal Medicine and Internal Specialities, University of Catania, Catania, Italy
    Aging Clin Exp Res 18:493-6. 2006
    ..Few studies in literature have investigated the gastric emptying of solids in elderly subjects. We assessed the differences between young and elderly subjects in the gastric emptying rate of solids by a radioisotopic method...
  69. ncbi request reprint Potential role of chitotriosidase gene in nonalcoholic fatty liver disease evolution
    Lucia Malaguarnera
    Department of Biomedical Sciences, University of Udine, Udine, Italy
    Am J Gastroenterol 101:2060-9. 2006
    ..We investigated chitotriosidase gene expression in Kupffer cells to determine the potential implication of this enzyme in the inflammation and in the progression from uncomplicated steatosis to steatohepatitis with progressive fibrosis...
  70. ncbi request reprint The extreme longevity: the state of the art in Italy
    Claudio Franceschi
    Exp Gerontol 43:45-52. 2008
  71. ncbi request reprint L-carnitine reduces severity of physical and mental fatigue and improves daily activities in the elderly
    Mariano Malaguarnera
    South Med J 99:315-6. 2006
  72. ncbi request reprint Plasma lipid composition and LDL oxidation
    Patrizia Brizzi
    Diabetes Service, Department of Medicine, University of Sassari, Italy
    Clin Chem Lab Med 41:56-60. 2003
    ..Both LDL/TG and LDL/HDL ratios can be used as predictive parameters of in vivo LDL oxidation...
  73. ncbi request reprint B cells in the aged: CD27, CD5, and CD40 expression
    Giuseppina Colonna-Romano
    Grupppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory, 211, 90134, Palermo, Italy
    Mech Ageing Dev 124:389-93. 2003
    ....
  74. ncbi request reprint Terlipressin and albumin in patients with cirrhosis and type I hepatorenal syndrome
    Sergio Neri
    Department of Internal Medicine and Systemic Diseases, Liver Operative Unit, Catania University Polyclinic, Catania 95123, Italy
    Dig Dis Sci 53:830-5. 2008
    ..Liver and renal function, plasma renin activity, and aldosterone plasma levels were monitored...