Jeanette A M Maier

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Expression analysis and modulation by HIV-Tat of the tyrosine phosphatase HD-PTP
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Italy
    J Cell Biochem 98:301-8. 2006
  2. ncbi request reprint Gravitational unloading induces an anti-angiogenic phenotype in human microvascular endothelial cells
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi 74, Milan, Italy
    J Cell Biochem 104:129-35. 2008
  3. ncbi request reprint Insights into the mechanisms involved in magnesium-dependent inhibition of primary tumor growth
    Jeanette A M Maier
    Dipartimento di Scienze Precliniche LITA Vialba, Universita di Milano, Milano, Italy
    Nutr Cancer 59:192-8. 2007
  4. doi request reprint Endothelial cells and magnesium: implications in atherosclerosis
    Jeanette A M Maier
    Dipartimento di Scienze Cliniche L Sacco, Universita di Milano, Via G B Grassi 74, Milano, Italy
    Clin Sci (Lond) 122:397-407. 2012
  5. doi request reprint HD-PTP inhibits endothelial migration through its interaction with Src
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi 74, Milan, Italy
    Int J Biochem Cell Biol 41:687-93. 2009
  6. ncbi request reprint Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis
    Jeanette A M Maier
    Department of Preclinical Sciences LITA Vialba, University of Milan, Via GB Grassi 74, 20157, Milan, Italy
    Biochim Biophys Acta 1689:13-21. 2004
  7. ncbi request reprint High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro
    Jeanette A M Maier
    University of Milan, Department of Preclinical Sciences LITA Vialba, Via GB Grassi 74, 20157 Milano, Italy
    Biochim Biophys Acta 1689:6-12. 2004
  8. ncbi request reprint Low magnesium and atherosclerosis: an evidence-based link
    Jeanette A M Maier
    Dipartimento di Scienze Precliniche LITA Vialba, Universita di Milano, Via GB Grassi 74, Milano 20157, Italy
    Mol Aspects Med 24:137-46. 2003
  9. ncbi request reprint The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Front Biosci 11:2138-43. 2006
  10. ncbi request reprint Low-magnesium induces senescent features in cultured human endothelial cells
    Silvia Ferrè
    University of Milan, Department of Preclinical Sciences LITA Vialba, Milano, Italy
    Magnes Res 20:66-71. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Expression analysis and modulation by HIV-Tat of the tyrosine phosphatase HD-PTP
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Italy
    J Cell Biochem 98:301-8. 2006
    ..These results suggest that HD-PTP amounts might be regulated both at the transcriptional and post-transcriptional levels...
  2. ncbi request reprint Gravitational unloading induces an anti-angiogenic phenotype in human microvascular endothelial cells
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi 74, Milan, Italy
    J Cell Biochem 104:129-35. 2008
    ..Our data might also explain why bioengineered tissues to be used for regenerative medicine fail to neovascularize when assembled in simulated hypogravity...
  3. ncbi request reprint Insights into the mechanisms involved in magnesium-dependent inhibition of primary tumor growth
    Jeanette A M Maier
    Dipartimento di Scienze Precliniche LITA Vialba, Universita di Milano, Milano, Italy
    Nutr Cancer 59:192-8. 2007
    ..Our results suggest that Mg has multiple and complex roles in tumor development...
  4. doi request reprint Endothelial cells and magnesium: implications in atherosclerosis
    Jeanette A M Maier
    Dipartimento di Scienze Cliniche L Sacco, Universita di Milano, Via G B Grassi 74, Milano, Italy
    Clin Sci (Lond) 122:397-407. 2012
    ....
  5. doi request reprint HD-PTP inhibits endothelial migration through its interaction with Src
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi 74, Milan, Italy
    Int J Biochem Cell Biol 41:687-93. 2009
    ....
  6. ncbi request reprint Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis
    Jeanette A M Maier
    Department of Preclinical Sciences LITA Vialba, University of Milan, Via GB Grassi 74, 20157, Milan, Italy
    Biochim Biophys Acta 1689:13-21. 2004
    ....
  7. ncbi request reprint High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro
    Jeanette A M Maier
    University of Milan, Department of Preclinical Sciences LITA Vialba, Via GB Grassi 74, 20157 Milano, Italy
    Biochim Biophys Acta 1689:6-12. 2004
    ..Moreover, because it induces the synthesis of nitric oxide, this cation could be a helpful tool in hypertension as well as in preventing thrombosis...
  8. ncbi request reprint Low magnesium and atherosclerosis: an evidence-based link
    Jeanette A M Maier
    Dipartimento di Scienze Precliniche LITA Vialba, Universita di Milano, Via GB Grassi 74, Milano 20157, Italy
    Mol Aspects Med 24:137-46. 2003
    ..Magnesium, which is an inexpensive, natural and rather safe element, could be useful in preventing atherosclerosis and as an adjuvant therapy in patients with clinical manifestations of the disease...
  9. ncbi request reprint The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Front Biosci 11:2138-43. 2006
    ..HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor does not affect protein levels, Fibroblast Growth Factor-2 induces HD-PTP degradation via the proteasome system...
  10. ncbi request reprint Low-magnesium induces senescent features in cultured human endothelial cells
    Silvia Ferrè
    University of Milan, Department of Preclinical Sciences LITA Vialba, Milano, Italy
    Magnes Res 20:66-71. 2007
    ..Since endothelial senescence contributes to atherogenesis, our findings indicating that low Mg promotes senescence may shed some light on the molecular mechanisms linking Mg deficiency to cardiovascular diseases...
  11. doi request reprint Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB
    Silvia Ferrè
    Department of Clinical Sciences L Sacco, Universita di Milano, Milano, Italy
    Biochim Biophys Acta 1802:952-8. 2010
    ..These results indicate that low magnesium promotes endothelial dysfunction by inducing pro-inflammatory and pro-atherogenic events...
  12. ncbi request reprint N6-isopentenyladenosine and its analogue N6-benzyladenosine induce cell cycle arrest and apoptosis in bladder carcinoma T24 cells
    Sara Castiglioni
    Dipartimento di Scienze Biomediche e Cliniche Luigi Sacco, Universita di Milano, Milano, Italy
    Anticancer Agents Med Chem 13:672-8. 2013
    ....
  13. doi request reprint Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells
    Erika Baldoli
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Via GB Grassi, 74, 20157 Milano, Italy
    Angiogenesis 15:47-57. 2012
    ..Our results point to magnesium and TRPM7 as a modulators of the angiogenic phenotype of microvascular endothelial cells...
  14. ncbi request reprint Alterations of the actin cytoskeleton and increased nitric oxide synthesis are common features in human primary endothelial cell response to changes in gravity
    Silvia Versari
    CNR ISTM, Istituto di Scienze e Tecnologie Molecolari, Via Golgi, 19, Milano, Italy
    Biochim Biophys Acta 1773:1645-52. 2007
    ..Our results indicate that cytoskeletal alterations and increased nitric oxide production represent common denominators in endothelial responses to both hypogravity and hypergravity...
  15. doi request reprint Synthesis and evaluation of in vitro anticancer activity of some novel isopentenyladenosine derivatives
    Roberta Ottria
    Dipartimento di Scienze Cliniche Luigi Sacco, Via G B Grassi 74, Universita degli Studi di Milano, 20157 Milano, Italy
    Bioorg Med Chem 18:4249-54. 2010
    ..We conclude that the integrity of ribosidic and purine moiety and the N(6) position of the chain are essential for maintaining the antiproliferative activity...
  16. ncbi request reprint Magnesium and microvascular endothelial cells: a role in inflammation and angiogenesis
    Daniela Bernardini
    University of Milan, Department of Preclinical Sciences LITA Vialba, Milano, Italy
    Front Biosci 10:1177-82. 2005
    ..Our results demonstrate a direct role of Mg in modulating microvascular functions and provide a molecular explanation to the link among Mg, angiogenesis and inflammation observed in in vivo models...
  17. doi request reprint Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation
    Marzia Leidi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Italy
    J Nutr Biochem 23:1224-9. 2012
    ....
  18. ncbi request reprint Differential expression of EDF-1 and endothelial nitric oxide synthase by proliferating, quiescent and senescent microvascular endothelial cells
    Daniela Bernardini
    University of Milan, Department of Preclinical Sciences LITA Vialba, Via GB Grassi, 74 20157 Milan, Italy
    Biochim Biophys Acta 1745:265-72. 2005
    ..The modulation of EDF-1 in microvascular endothelial cells might offer new insights into the molecular events involved in angiogenesis and in microvascular dysfunctions in the elderly...
  19. doi request reprint The effects of silencing EDF-1 in human endothelial cells
    Marzia Leidi
    Department of Clinical Sciences, Università di Milano Medical School, Via GB Grassi 74, 20157 Milano, Italy
    Atherosclerosis 211:55-60. 2010
    ..To understand whether EDF-1 is implicated in regulating endothelial function, we silenced EDF-1 expression using small hairpin (sh) RNA...
  20. doi request reprint Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Cancer Lett 273:155-63. 2009
    ..Following stimulation with EGF, HD-PTP is tyrosine-phosphorylated and releases FAK which will ultimately contribute to the turn-over of focal adhesion and, therefore, to cell motility...
  21. pmc Regulation and function of TRPM7 in human endothelial cells: TRPM7 as a potential novel regulator of endothelial function
    Erika Baldoli
    Dipartimento di Scienze Biomediche e Cliniche L Sacco, Universita di Milano, Milano, Italy
    PLoS ONE 8:e59891. 2013
    ..Our results indicate that TRPM7 modulates endothelial behavior and that any condition leading to TRPM7 upregulation might impair endothelial function...
  22. doi request reprint EDF-1 contributes to the regulation of nitric oxide release in VEGF-treated human endothelial cells
    Marzia Leidi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Milano, Italy
    Eur J Cell Biol 89:654-60. 2010
    ..Our results suggest EDF-1 as a novel contributor to the complex regulation of eNOS activity in human endothelial cells...
  23. ncbi request reprint Differential response to Tat and FGF-2 of two novel clonal populations derived from murine Kaposi-like lesions developing in Tat transgenic mice
    Zhihao Wu
    Universita di Milano, DISP Vialba, Via G B Grassi, 74 Milan, Italy
    Microvasc Res 63:19-26. 2002
    ..We conclude that (i) the response of SC to Tat is density dependent and (ii) the angiogenic effect of Tat on both MEC and SC requires the presence of FGF-2...
  24. doi request reprint The tyrosine phosphatase HD-PTP (PTPN23) is degraded by calpains in a calcium-dependent manner
    Sara Castiglioni
    Department of Clinical Sciences L Sacco, Universita di Milano, Via GB Grassi, 74 Milano, Italy
    Biochem Biophys Res Commun 421:380-3. 2012
    ....
  25. ncbi request reprint The tyrosine phosphatase HD-PTP: A novel player in endothelial migration
    Sara Castiglioni
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Biochem Biophys Res Commun 364:534-9. 2007
    ..We suggest that HD-PTP contributes to the regulation of endothelial motility by modulating the tyrosine phosphorylation of FAK...
  26. ncbi request reprint Impact of modeled microgravity on microvascular endothelial cells
    Sabrina Cotrupi
    Dipartimento di Scienze Precliniche, Universita di Milano, Medical School, Milan, Italy
    Biochim Biophys Acta 1746:163-8. 2005
    ....
  27. doi request reprint High magnesium inhibits human osteoblast differentiation in vitro
    Marzia Leidi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Milano, Italy
    Magnes Res 24:1-6. 2011
    ..We conclude that high magnesium levels impair osteoblast activity and might therefore contribute to bone disease...
  28. ncbi request reprint Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization
    Sofia I M Carlsson
    Department of Preclinical Sciences, LITA Vialba, Universita di Milano, Via GB Grassi 74, Milan, Italy
    Biochim Biophys Acta 1642:173-9. 2003
    ..We hypothesize that the reduction in the amounts of actin in response to microgravity represents an adaptative mechanism to avoid the accumulation of redundant actin fibers...
  29. doi request reprint Novel isopentenyladenosine analogues: synthesis, characterization, and evaluation of antiproliferative activity on bladder carcinoma cells
    Roberta Ottria
    Dipartimento di Scienze Precliniche LITA Vialba Universita degli Studi di Milano, Milano, Italy
    Nucleosides Nucleotides Nucleic Acids 28:736-51. 2009
    ..These results indicate that the integrity of the ribose ring is required for the cytostatic activity of iPA...
  30. doi request reprint Magnesium and cancer: a dangerous liason
    Sara Castiglioni
    Universita di Milano, Dipartimento di Scienze Cliniche Luigi Sacco, Milano, Italy
    Magnes Res 24:S92-100. 2011
    ..More studies should be undertaken in order to disclose whether a simple and inexpensive intervention to optimize magnesium intake might be helpful in the prevention and treatment of cancer...
  31. ncbi request reprint Is HSP70 upregulation crucial for cellular proliferative response in simulated microgravity?
    Sabrina Cotrupi
    University of Milan, Department of Preclinical Sciences LITA Vialba, Milan, Italy
    J Gravit Physiol 11:P173-6. 2004
    ..We therefore propose that only the cells which sense microgravity as a stressful condition and, consequently, overexpress HSP70 maintain their proliferative potential in simulated microgravity...
  32. pmc Magnesium and osteoporosis: current state of knowledge and future research directions
    Sara Castiglioni
    Department of Biomedical and Clinical Sciences L Sacco, University of Milan, Via GB Grassi 74, Milan I 20157, Italy
    Nutrients 5:3022-33. 2013
    ..Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity. ..
  33. doi request reprint Extracellular magnesium and in vitro cell differentiation: different behaviour of different cells
    Sara Castiglioni
    Dipartimento di Scienze Biomediche e Cliniche L Sacco, Universita di Milano, Milano I 20157, Italy
    Magnes Res 26:24-31. 2013
    ..We conclude that the extracellular magnesium concentration affects the differentiation of various cell types...
  34. doi request reprint Transcriptional coactivator EDF-1 is required for PPARgamma-stimulated adipogenesis
    Marzia Leidi
    Department of Preclinical Sciences, Università di Milano Medical School, Via GB Grassi 74, Milan, Italy
    Cell Mol Life Sci 66:2733-42. 2009
    ..These results demonstrate that EDF-1 is required for PPARgamma transcriptional activation during 3T3-L1 differentiation...
  35. ncbi request reprint Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription
    Fabrizio Bolognese
    University of Milan, Dipartimento di Scienze Precliniche LITA Vialba, Via GB Grassi 74, Milan, Italy
    Gene 374:87-95. 2006
    ..Deletion of Sp1/Sp3 and NF-Y consensus sequences resulted in the total loss of EDF-1 promoter activity. Our studies indicate that Sp1 and NFY binding is essential for EDF-1 promoter activity...
  36. ncbi request reprint Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice
    Anna Nasulewicz
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R Weigl Street, 53 114 Wrocław, Poland
    Biochim Biophys Acta 1739:26-32. 2004
    ..In conclusion, our results demonstrate a direct role of magnesium in tumor growth and also point at deleterious effect of low magnesium status on tumor metastasis...
  37. pmc A connection between magnesium deficiency and aging: new insights from cellular studies
    David W Killilea
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA, USA
    Magnes Res 21:77-82. 2008
    ....
  38. ncbi request reprint Magnesium and the inflammatory response: potential physiopathological implications
    Andrzej Mazur
    Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR 1019, Centre de Recherche en Nutrition Humaine d Auvergne, INRA, Theix, St Genes Champanelle, France
    Arch Biochem Biophys 458:48-56. 2007
    ....
  39. ncbi request reprint Magnesium deficiency and endothelial dysfunction: is oxidative stress involved?
    Federica I Wolf
    Istituto di Patologia Generale, e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Roma, Italy
    Magnes Res 21:58-64. 2008
    ..We conclude that low Mg transiently leads to pro-oxidant effects. We suggest that different molecules, including pro-inflammatory cytokines, might be involved in promoting endothelial dysfunction...