Valerio Magnaghi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc GABA-B receptors in the PNS have a role in Schwann cells differentiation?
    Patrizia Procacci
    Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano Milan, Italy
    Front Cell Neurosci 6:68. 2012
  2. pmc The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells
    Alessandro Faroni
    Blond McIndoe Laboratories, Regenerative Biomedicine, School of Medicine, The University of Manchester Manchester, UK
    Front Endocrinol (Lausanne) 2:103. 2011
  3. doi request reprint Altered peripheral myelination in mice lacking GABAB receptors
    Valerio Magnaghi
    Department of Endocrinology and Centre of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Mol Cell Neurosci 37:599-609. 2008
  4. doi request reprint Biological performance of a novel biodegradable polyamidoamine hydrogel as guide for peripheral nerve regeneration
    Valerio Magnaghi
    Department of Endocrinology, Pathophysiology, and Applied Biology, Universita degli Studi di Milano, via G Balzaretti 9, 20133 Milan, Italy
    J Biomed Mater Res A 98:19-30. 2011
  5. ncbi request reprint GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Mol Neurosci 28:89-102. 2006
  6. ncbi request reprint GABAB receptors in Schwann cells influence proliferation and myelin protein expression
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur J Neurosci 19:2641-9. 2004
  7. ncbi request reprint Neuroactive steroids: A therapeutic approach to maintain peripheral nerve integrity during neurodegenerative events
    Emanuela Leonelli
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Mol Neurosci 28:65-76. 2006
  8. ncbi request reprint Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence of Neurodegenerative Diseases, University of Milan, Milan, Italy
    J Peripher Nerv Syst 11:111-8. 2006
  9. doi request reprint Degradable poly(amidoamine) hydrogels as scaffolds for in vitro culturing of peripheral nervous system cells
    Nicolò Mauro
    Dipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy
    Macromol Biosci 13:332-47. 2013
  10. ncbi request reprint Peripheral nerves: a target for the action of neuroactive steroids
    Roberto C Melcangi
    Department of Endocrinology, University of Milan, Italy
    Brain Res Brain Res Rev 48:328-38. 2005

Collaborators

Detail Information

Publications27

  1. pmc GABA-B receptors in the PNS have a role in Schwann cells differentiation?
    Patrizia Procacci
    Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano Milan, Italy
    Front Cell Neurosci 6:68. 2012
    ..Data from the literature and our recent findings corroborate the role of the GABAergic system and GABA-B receptors in the peripheral nervous system, opening new perspectives on the mechanisms controlling the differentiation of SC...
  2. pmc The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells
    Alessandro Faroni
    Blond McIndoe Laboratories, Regenerative Biomedicine, School of Medicine, The University of Manchester Manchester, UK
    Front Endocrinol (Lausanne) 2:103. 2011
    ....
  3. doi request reprint Altered peripheral myelination in mice lacking GABAB receptors
    Valerio Magnaghi
    Department of Endocrinology and Centre of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Mol Cell Neurosci 37:599-609. 2008
    ..In summary, our findings implicate GABA(B) receptors in the PNS myelination process and raise the possibility that PNS alterations contribute to the sensory phenotypes of GABA(B1)-deficient mice...
  4. doi request reprint Biological performance of a novel biodegradable polyamidoamine hydrogel as guide for peripheral nerve regeneration
    Valerio Magnaghi
    Department of Endocrinology, Pathophysiology, and Applied Biology, Universita degli Studi di Milano, via G Balzaretti 9, 20133 Milan, Italy
    J Biomed Mater Res A 98:19-30. 2011
    ..Moreover, nerve regeneration was morphologically sound and the quality of functional recovery satisfactory. In conclusion, PAA hydrogel scaffolds may represent a novel and promising material for peripheral nerve regeneration...
  5. ncbi request reprint GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Mol Neurosci 28:89-102. 2006
    ..The results suggest, at least in the myelinating cells of the PNS, a cross-interaction within the GABAergic receptor system, via GABAA and GABAB receptors and neuroactive steroids...
  6. ncbi request reprint GABAB receptors in Schwann cells influence proliferation and myelin protein expression
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur J Neurosci 19:2641-9. 2004
    ..e. glycoprotein Po, peripheral myelin protein 22, myelin-associated glycoprotein, connexin 32), providing evidence for a physiological role of GABA(B) receptors in the glial cells of the peripheral nervous system...
  7. ncbi request reprint Neuroactive steroids: A therapeutic approach to maintain peripheral nerve integrity during neurodegenerative events
    Emanuela Leonelli
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Mol Neurosci 28:65-76. 2006
    ..On this basis, the hypothesis that neuroactive steroids might represent a new therapeutic strategy for peripheral neuropathy is proposed...
  8. ncbi request reprint Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence of Neurodegenerative Diseases, University of Milan, Milan, Italy
    J Peripher Nerv Syst 11:111-8. 2006
    ..This finding might represent an important background for sex-specific therapies of acquired and inherited peripheral neuropathies...
  9. doi request reprint Degradable poly(amidoamine) hydrogels as scaffolds for in vitro culturing of peripheral nervous system cells
    Nicolò Mauro
    Dipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy
    Macromol Biosci 13:332-47. 2013
    ....
  10. ncbi request reprint Peripheral nerves: a target for the action of neuroactive steroids
    Roberto C Melcangi
    Department of Endocrinology, University of Milan, Italy
    Brain Res Brain Res Rev 48:328-38. 2005
    ....
  11. doi request reprint Schwann-like adult stem cells derived from bone marrow and adipose tissue express γ-aminobutyric acid type B receptors
    Alessandro Faroni
    Blond McIndoe Laboratories, Regenerative Biomedicine, The University of Manchester, Manchester, United Kingdom
    J Neurosci Res 89:1351-62. 2011
    ..The presence of functional GABA-B receptors on differentiated stem cells opens new opportunities for a possible pharmacological modulation of their physiology and phenotype...
  12. doi request reprint Cobalamin deficiency-induced changes of epidermal growth factor (EGF)-receptor expression and EGF levels in rat spinal cord
    Elena Mutti
    Città Studi Department, Laboratory of Neuropathology, University of Milan, Via Mangiagalli 31, I 20133 Milano, Italy
    Brain Res 1376:23-30. 2011
    ..These findings demonstrate that Cbl deficiency dysregulates the EGFR-EGF dyad in these tissues...
  13. ncbi request reprint The synthesis of glycoprotein Po and peripheral myelin protein 22 in sciatic nerve of male rats is modulated by testosterone metabolites
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, via G Balzaretti 9, 20133 Milan, Italy
    Brain Res Mol Brain Res 126:67-73. 2004
    ..The observations here reported clearly show similarities and dissimilarities with the effects exerted by other members of neuroactive steroid family, like for instance progesterone derivatives, which will be discussed in text...
  14. ncbi request reprint Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats
    Emanuela Leonelli
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, via G Balzaretti 9, 20133 Milano, Italy
    Mech Ageing Dev 126:1159-63. 2005
    ..These findings support the potential role of PBR ligands to prevent aging-associated peripheral nerve degeneration...
  15. ncbi request reprint Actions of progesterone and its 5alpha-reduced metabolites on the major proteins of the myelin of the peripheral nervous system
    Luciano Martini
    Department of Endocrinology, Center of Excellence on Neurodegenerative Diseases, University of Milan, via G Balzaretti 9, 20133 Milan, Italy
    Steroids 68:825-9. 2003
    ....
  16. doi request reprint GABA synthesis in Schwann cells is induced by the neuroactive steroid allopregnanolone
    Valerio Magnaghi
    Department of Endocrinology, Physiopathology and Applied Biology, Universita degli Studi di Milano, Milan, Italy
    J Neurochem 112:980-90. 2010
    ....
  17. doi request reprint Expression of functional γ-aminobutyric acid type A receptors in Schwann-like adult stem cells
    Alessandro Faroni
    Blond McIndoe Laboratories, The University of Manchester, School of Biomedicine, 3 108 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    J Mol Neurosci 47:619-30. 2012
    ..Functional GABA-A and GABA-B receptors represent a possible pharmacological target to modulate SC-like stem cells physiology...
  18. doi request reprint Baclofen modulates the expression and release of neurotrophins in schwann-like adipose stem cells
    Alessandro Faroni
    Blond McIndoe Laboratories, Manchester Academic Health Science Centre, The University of Manchester, School of Biomedicine, 3 108 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    J Mol Neurosci 49:233-43. 2013
    ..The possibility to modulate the neurotrophic potential of adult stem cell, acting on functional GABAergic receptors, could represent a novel pharmacological approach to improve nerve regeneration...
  19. doi request reprint Chapter 15: Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration
    Valerio Magnaghi
    Department of Endocrinology, Physiopathology, Applied Biology, Universita degli Studi di Milano, 20133 Milan, Italy
    Int Rev Neurobiol 87:295-315. 2009
    ..In this review, we survey the latest findings on these factors and assess their potential as novel promising treatments for peripheral neuropathies caused by injury...
  20. ncbi request reprint Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence of Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Mol Neurosci 31:149-57. 2007
    ....
  21. doi request reprint Comparative proteomic profile of rat sciatic nerve and gastrocnemius muscle tissues in ageing by 2-D DIGE
    Daniele Capitanio
    Department of Sciences and Biomedical Technologies, University of Milan, Segrate, MI, Italy
    Proteomics 9:2004-20. 2009
    ..Only beta enolase and tropomyosin 1alpha were differentially expressed in the tissues...
  22. doi request reprint Perineuronal satellite cells in mouse spinal ganglia express the gap junction protein connexin43 throughout life with decline in old age
    Patrizia Procacci
    Institute of Histology, Embryology and Neurocytology, University of Milan, Via Mangiagalli 14, Milan, Italy
    Brain Res Bull 75:562-9. 2008
    ..This latter finding is consistent with observations in non-nervous tissues, and the hypothesis that a prominent decrease in Cx43 is a marker of senescence...
  23. doi request reprint Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers
    Alessandro Faroni
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy Blond McIndoe Laboratories, The University of Manchester, Institute of Inflammation and Repair, M13 9PT, Manchester, United Kingdom
    Glia 62:548-65. 2014
    ....
  24. doi request reprint Neurosteroid allopregnanolone regulates EAAC1-mediated glutamate uptake and triggers actin changes in Schwann cells
    Carla Perego
    Department of Molecular Sciences Applied to Biosystems, Universita degli Studi di Milano, Milan, Italy
    J Cell Physiol 227:1740-51. 2012
    ..Glutamate transporters may represent a potential therapeutic target to control Schwann cell physiology...
  25. ncbi request reprint Decreased GFAP-mRNA expression in spinal cord of cobalamin-deficient rats
    Valerio Magnaghi
    Institute of General Pathology, University of Milan, 20133 Milan, Italy
    FASEB J 16:1820-2. 2002
    ..These results demonstrate that: a) the neurotrophic action of Cbl in rat CNS occurs in a zonal manner; and b) Cbl deficiency does not affect myelin synthesis (with the sole exception of the hypothalamus)...
  26. ncbi request reprint Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain
    Paola Sacerdote
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Via Vanvitelli 32, 20129 Milan, Italy
    J Neuroimmune Pharmacol 8:202-11. 2013
    ..The modulation of inflammatory molecules appears to be a common trait accomplished throughout different mechanisms by different drugs that might converge in neuropathic pain modulation...
  27. ncbi request reprint Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats
    Inigo Azcoitia
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense, E 28040 Madrid, Spain
    Neurobiol Aging 24:853-60. 2003
    ..These data suggest that P, DHP and THP may represent useful therapeutic alternatives to maintain peripheral nerve integrity in aged animals...