Mohamad Maghnie

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi request reprint Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement
    Mohamad Maghnie
    Department of Pediatrics, University of Pavia, Italy
    Eur J Endocrinol 152:589-96. 2005
  2. ncbi request reprint Adult height in patients with permanent growth hormone deficiency with and without multiple pituitary hormone deficiencies
    Mohamad Maghnie
    Department of Pediatrics, Instituto di Ricovero e Cura a Carattere Scientifico Giannina Gaslini, University of Genoa, Largo Gerolamo Gaslini 5, 16147 Genoa, Italy
    J Clin Endocrinol Metab 91:2900-5. 2006
  3. ncbi request reprint Novel HESX1 mutations associated with a life-threatening neonatal phenotype, pituitary aplasia, but normally located posterior pituitary and no optic nerve abnormalities
    Marie Laure Sobrier
    Institut National de la Sante et de la Recherche Medicale, U654, Hopital Henri Mondor, Creteil F 94010, France
    J Clin Endocrinol Metab 91:4528-36. 2006
  4. doi request reprint The glucagon test in the diagnosis of growth hormone deficiency in children with short stature younger than 6 years
    Andrea Secco
    Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini Institute, University of Genova, 16147 Genova, Italy
    J Clin Endocrinol Metab 94:4251-7. 2009
  5. doi request reprint Reassessment of the growth hormone status in young adults with childhood-onset growth hormone deficiency: reappraisal of insulin tolerance testing
    Andrea Secco
    Department of Pediatrics, Instituto di Ricovero e Cura aCarattere Scientifico, Giannina Gaslini Institute, University of Genova, 16147 Genova, Italy
    J Clin Endocrinol Metab 94:4195-204. 2009
  6. ncbi request reprint Relationship between the morphological evaluation of the pituitary and the growth hormone (GH) response to GH-releasing hormone Plus arginine in children and adults with congenital hypopituitarism
    M Maghnie
    Department of Pediatrics, IRCCS Policlinico S Matteo, University of Pavia, I 27100 Pavia, Italy
    J Clin Endocrinol Metab 86:1574-9. 2001
  7. ncbi request reprint Dynamic endocrine testing and magnetic resonance imaging in the long-term follow-up of childhood langerhans cell histiocytosis
    M Maghnie
    Department of Pediatrics, University, IRCCS Policlinico S Matteo, Pavia, Italy
    J Clin Endocrinol Metab 83:3089-94. 1998
  8. ncbi request reprint Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults
    M Maghnie
    Department of Pediatrics, University, IRCCS Policlinico S Matteo, Pavia, Italy
    J Clin Endocrinol Metab 84:1324-8. 1999
  9. ncbi request reprint Idiopathic central diabetes insipidus is associated with abnormal blood supply to the posterior pituitary gland caused by vascular impairment of the inferior hypophyseal artery system
    Mohamad Maghnie
    Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S Matteo, University of Pavia, 27100 Pavia
    J Clin Endocrinol Metab 89:1891-6. 2004
  10. ncbi request reprint Central diabetes insipidus in children and young adults
    M Maghnie
    Department of Pediatrics, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Italy
    N Engl J Med 343:998-1007. 2000

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement
    Mohamad Maghnie
    Department of Pediatrics, University of Pavia, Italy
    Eur J Endocrinol 152:589-96. 2005
    ....
  2. ncbi request reprint Adult height in patients with permanent growth hormone deficiency with and without multiple pituitary hormone deficiencies
    Mohamad Maghnie
    Department of Pediatrics, Instituto di Ricovero e Cura a Carattere Scientifico Giannina Gaslini, University of Genoa, Largo Gerolamo Gaslini 5, 16147 Genoa, Italy
    J Clin Endocrinol Metab 91:2900-5. 2006
    ..However, the outcome of patients with permanent GH deficiency (GHD) has not yet been reported...
  3. ncbi request reprint Novel HESX1 mutations associated with a life-threatening neonatal phenotype, pituitary aplasia, but normally located posterior pituitary and no optic nerve abnormalities
    Marie Laure Sobrier
    Institut National de la Sante et de la Recherche Medicale, U654, Hopital Henri Mondor, Creteil F 94010, France
    J Clin Endocrinol Metab 91:4528-36. 2006
    ..Very few HESX1 mutations have been identified in humans; although in those cases the disease phenotype shows considerable variability, all but one of the patients display an ectopic posterior pituitary and/or optic nerve abnormalities...
  4. doi request reprint The glucagon test in the diagnosis of growth hormone deficiency in children with short stature younger than 6 years
    Andrea Secco
    Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini Institute, University of Genova, 16147 Genova, Italy
    J Clin Endocrinol Metab 94:4251-7. 2009
    ..Few studies have addressed the diagnostic role of the glucagon test in children with suspected GH deficiency (GHD)...
  5. doi request reprint Reassessment of the growth hormone status in young adults with childhood-onset growth hormone deficiency: reappraisal of insulin tolerance testing
    Andrea Secco
    Department of Pediatrics, Instituto di Ricovero e Cura aCarattere Scientifico, Giannina Gaslini Institute, University of Genova, 16147 Genova, Italy
    J Clin Endocrinol Metab 94:4195-204. 2009
    ....
  6. ncbi request reprint Relationship between the morphological evaluation of the pituitary and the growth hormone (GH) response to GH-releasing hormone Plus arginine in children and adults with congenital hypopituitarism
    M Maghnie
    Department of Pediatrics, IRCCS Policlinico S Matteo, University of Pavia, I 27100 Pavia, Italy
    J Clin Endocrinol Metab 86:1574-9. 2001
    ....
  7. ncbi request reprint Dynamic endocrine testing and magnetic resonance imaging in the long-term follow-up of childhood langerhans cell histiocytosis
    M Maghnie
    Department of Pediatrics, University, IRCCS Policlinico S Matteo, Pavia, Italy
    J Clin Endocrinol Metab 83:3089-94. 1998
    ..Similarly, a standard MRI was not predictive, although dynamic imaging may be informative regarding evolving pituitary hormone deficiency...
  8. ncbi request reprint Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults
    M Maghnie
    Department of Pediatrics, University, IRCCS Policlinico S Matteo, Pavia, Italy
    J Clin Endocrinol Metab 84:1324-8. 1999
    ....
  9. ncbi request reprint Idiopathic central diabetes insipidus is associated with abnormal blood supply to the posterior pituitary gland caused by vascular impairment of the inferior hypophyseal artery system
    Mohamad Maghnie
    Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S Matteo, University of Pavia, 27100 Pavia
    J Clin Endocrinol Metab 89:1891-6. 2004
    ..This is in keeping with vascular impairment of the inferior hypophyseal artery system and suggests that abnormal blood supply to the posterior pituitary gland is associated with what, until now, has been considered idiopathic CDI...
  10. ncbi request reprint Central diabetes insipidus in children and young adults
    M Maghnie
    Department of Pediatrics, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Italy
    N Engl J Med 343:998-1007. 2000
    ..Central diabetes insipidus is rare in children and young adults, and up to 50 percent of cases are idiopathic. The clinical presentation and the long-term course of this disorder are largely undefined...
  11. ncbi request reprint Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests
    M Maghnie
    Department of Pediatrics, University of Pavia, Italy
    Eur J Endocrinol 152:735-41. 2005
    ....
  12. ncbi request reprint Magnetic resonance imaging of the hypothalamus-pituitary unit in childrensuspected of hypopituitarism: who, how and when toinvestigate
    M Maghnie
    Department of Pediatrics, IRCCS S Matteo Policlinic, University of Pavia, Pavia, Italy
    J Endocrinol Invest 27:496-509. 2004
    ....
  13. ncbi request reprint GHRH plus arginine in the diagnosis of acquired GH deficiency of childhood-onset
    Mohamad Maghnie
    Department of Pediatrics, IRCCS Policlinico S Matteo, University of Pavia, Viale Golgi 2, I 27100 Pavia, Italy
    J Clin Endocrinol Metab 87:2740-4. 2002
    ..Finally, the number of pituitary hormone deficits and the patient's age affect the GH response to GHRH plus ARG...
  14. doi request reprint The accuracy of the glucagon test compared to the insulin tolerance test in the diagnosis of adrenal insufficiency in young children with growth hormone deficiency
    Natascia Di Iorgi
    Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, University of Genova, Largo Gerolamo Gaslini, 5, 16147, Genova, Italy
    J Clin Endocrinol Metab 95:2132-9. 2010
    ..The accuracy of the glucagon test in the diagnosis of central adrenal insufficiency in young children has not yet been definitively established...
  15. doi request reprint Thyroid function and structure are affected in childhood obesity
    Giorgio Radetti
    Department of Pediatrics, Regional Hospital, Via L Boehler 5, 39100 Bolzano, Italy
    J Clin Endocrinol Metab 93:4749-54. 2008
    ..The aim of our study was to evaluate the involvement of the thyroid gland in a large group of obese children...
  16. doi request reprint Diabetes insipidus--diagnosis and management
    Natascia Di Iorgi
    Department of Pediatrics, IRCCS G Gaslini, University of Genoa, Largo Gerolamo Gaslini 5, Genoa, Italy
    Horm Res Paediatr 77:69-84. 2012
    ..MRI STIR (short-inversion-time inversion recovery sequencing) is a promising technology for the early identification of LCH-dependent CDI...
  17. doi request reprint Developmental abnormalities of the posterior pituitary gland
    Natascia Di Iorgi
    Department of Pediatrics, Gaslini Institute, University of Genova, Genova, Italy
    Endocr Dev 14:83-94. 2009
    ....
  18. ncbi request reprint Diabetes insipidus in craniopharyngioma: postoperative management of water and electrolyte disorders
    Stefano Ghirardello
    Department of Pediatrics, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    J Pediatr Endocrinol Metab 19:413-21. 2006
    ..We review here the pathophysiology and management of the multiple fluid disorders encountered following surgery for craniopharyngiomas...
  19. doi request reprint Pituitary gland imaging and outcome
    Natascia Di Iorgi
    Department of Pediatrics, IRCCS Giannina Gaslini Institute, University of Genova, Genova, Italy
    Endocr Dev 23:16-29. 2012
    ....
  20. ncbi request reprint Transient beneficial effect of GH replacement therapy and topical GH application on skin ulcers in a boy with prolidase deficiency
    V Monafo
    Department of Pediatric Sciences, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Pediatr Dermatol 17:227-30. 2000
    ....
  21. ncbi request reprint Endoscopic approaches to the cranial base: perspectives and realities
    D Locatelli
    Neurosurgical Clinic, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Childs Nerv Syst 16:686-91. 2000
    ....
  22. doi request reprint Magnetic resonance imaging of CNS in 15 043 children with GH deficiency in KIGS (Pfizer International Growth Database)
    Mohamad Maghnie
    Department of Pediatrics, IRCCS Giannina Gaslini, University of Genova, Largo G Gaslini 5, 16 147 Genova, Italy
    Eur J Endocrinol 168:211-7. 2013
    ..The aim of the study was to document the frequency of neuroanatomical abnormalities in a very large cohort of children with GHD and to relate these findings to patient clinical characteristics...
  23. ncbi request reprint Adult height in children with short stature and idiopathic delayed puberty after different management
    Stefano Zucchini
    Department of Pediatrics, Azienda Ospedaliero Universitaria di Bologna S Orsola Malpighi, Via Massarenti 11, 40138, Bologna, Italy
    Eur J Pediatr 167:677-81. 2008
    ..Our data do not support the usefulness of growth-hormone therapy in improving adult height in subjects with short stature and delayed puberty, particularly in the female sex...
  24. doi request reprint Quantitative ultrasound detects bone impairment after bone marrow transplantation in children and adolescents affected by hematological diseases
    Natascia Di Iorgi
    Department of Pediatrics, IRCCS G Gaslini, University of Genova, Largo Gerolamo Gaslini, 5, 16147, Genova, Italy
    Bone 43:177-82. 2008
    ..We investigated bone status with quantitative ultrasound (QUS) technique in children and adolescents with hematological diseases before and after BMT...
  25. ncbi request reprint Current perspective on the pathogenesis of central diabetes insipidus
    Stefano Ghirardello
    Department of Pediatrics, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    J Pediatr Endocrinol Metab 18:631-45. 2005
    ..Molecular biology in selected patients may identify those with apparently idiopathic diabetes insipidus carrying the vasopressin-neurophysin II gene mutation...
  26. ncbi request reprint Diabetes insipidus
    Mohamad Maghnie
    Department of Paediatrics, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Horm Res 59:42-54. 2003
    ..Biopsy of enlarged pituitary stalk should be reserved for patients with a hypothalamic-pituitary mass and progressive thickening of the pituitary stalk, since spontaneous recovery may occur...
  27. ncbi request reprint Growth hormone secretory pattern and response to treatment in children with short stature followed to adult height
    Giorgio Radetti
    Department of Pediatrics, Regional Hospital of Bolzano, Bolzano, Department of Pediatrics, University of Brescia, Brescia, Italy
    Clin Endocrinol (Oxf) 59:27-33. 2003
    ..To compare the relative utility of GH stimulation tests and assays of spontaneous GH secretion as predictors of change in height standard deviation score at the end of GH treatment in children with short stature...
  28. ncbi request reprint Failure to increase insulin-like growth factor-I synthesis is involved in the mechanisms of growth retardation of children with inherited liver disorders
    M Maghnie
    Department of Pediatrics, University of Pavia, IRCCS Policlinico S Matteo, Italy
    Clin Endocrinol (Oxf) 48:747-55. 1998
    ....
  29. ncbi request reprint Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: a proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)
    G Federico
    Department of Pediatrics, Azienda Ospedaliero Universitaria Pisana, 56125 Pisa, Italy
    J Endocrinol Invest 29:732-7. 2006
    ..We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal children...
  30. ncbi request reprint Idiopathic central diabetes insipidus in children and young adults is commonly associated with vasopressin-cell antibodies and markers of autoimmunity
    Mohamad Maghnie
    Department of Paediatrics, IRCCS G Gaslini Institute, University of Genova, Italy
    Clin Endocrinol (Oxf) 65:470-8. 2006
    ..Autoimmune targeting of hypothalamic-neurohypophyseal structures in children and young adults with posterior pituitary and anterior pituitary dysfunction, as well as pituitary stalk involvement, are not yet completely understood...
  31. ncbi request reprint Timing of pituitary stalk assessment in Langerhans cell histiocytosis: "when" is sometimes more important than "what"
    Mohamad Maghnie
    J Clin Endocrinol Metab 89:4166; author reply 4166-7. 2004
  32. ncbi request reprint Cut-off limits of the GH response to GHRH plus arginine test and IGF-I levels for the diagnosis of GH deficiency in late adolescents and young adults
    Ginevra Corneli
    Endocrinology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Novara, Via Solaroli, 17, 28100 Novara, Italy
    Eur J Endocrinol 157:701-8. 2007
    ..To define the appropriate diagnostic cut-off limits for the GH response to GHRH+arginine (ARG) test and IGF-I levels, using receiver operating characteristics (ROC) curve analysis, in late adolescents and young adults...
  33. ncbi request reprint Results of early reevaluation of growth hormone secretion in short children with apparent growth hormone deficiency
    Sandro Loche
    Servizio di Endocrinologia Pediatrica, Ospedale Regionale per le Microcitemie, Cagliari, Clinica Pediatrica, Servizio Analisi Chimico Cliniche, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    J Pediatr 140:445-9. 2002
    ....
  34. ncbi request reprint Deterioration of growth hormone (GH) response and anterior pituitary function in young adults with childhood-onset GH deficiency and ectopic posterior pituitary: a two-year prospective follow-up study
    Natascia Di Iorgi
    AssociateDepartment of Pediatrics Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, University of Genova, Largo Gerolamo Gaslini, 5, 16147 Genova, Italy
    J Clin Endocrinol Metab 92:3875-84. 2007
    ..The current criteria for definition of partial GHD in young adults are still a subject of debate...
  35. ncbi request reprint Genetic analysis and evaluation of resistance to thyrotropin and growth hormone-releasing hormone in pseudohypoparathyroidism type Ib
    Giovanna Mantovani
    Department of Medical Sciences, Endocrine Unit, Fondazione Policlinico Instituto di Ricovero e Cura a Carattere Scientifico, University of Milan, 20122 Milan, Italy
    J Clin Endocrinol Metab 92:3738-42. 2007
    ..No study addressed the question of GH deficiency in PHP-Ib patients...
  36. ncbi request reprint The advantage of measuring spontaneous growth hormone (GH) secretion compared with the insulin tolerance test in the diagnosis of GH deficiency in young adults
    Giorgio Radetti
    Department of Paediatrics, Regional Hospital of Bolzano, Italy
    Clin Endocrinol (Oxf) 67:78-84. 2007
    ..The current GH threshold for biochemical definition of GHD in young adults is still a subject of debate...
  37. ncbi request reprint The pre-operative endocrine assessment of craniopharyngiomas
    Neil Hopper
    Department of Paediatric Endocrinology, St George s Hospital, London, UK
    J Pediatr Endocrinol Metab 19:325-7. 2006
    ..We review the available published data on pre-operative endocrine dysfunction and suggest an approach to assessment and management before surgery...
  38. ncbi request reprint GH response to ghrelin in subjects with congenital GH deficiency: evidence that ghrelin action requires hypothalamic-pituitary connections
    Mohamad Maghnie
    Department of Paediatrics, IRCCS Giannina Gaslini, University of Genova, Largo Gerolamo Gaslini, 5, 16147 Genova, Italy
    Eur J Endocrinol 156:449-54. 2007
    ..We aimed to investigate the GH-releasing effect of ghrelin in children and young adults with childhood-onset GHD...
  39. ncbi request reprint Is growth hormone treatment in young children safe for the heart?
    Giorgio Radetti
    J Clin Endocrinol Metab 89:5271-2. 2004
  40. ncbi request reprint Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development
    Giampiero I Baroncelli
    Department of Reproductive Medicine and Pediatrics, Division of Pediatrics, University of Pisa, and Paediatric Clinic, Genoa, Italy
    Bone 39:159-73. 2006
    ..It may be a useful tool to assess bone mineral status from early childhood to young-adulthood with a very small confounding effect related to bone sizes and without exposing the subjects to a source of radiation...
  41. ncbi request reprint Growth hormone-releasing hormone resistance in pseudohypoparathyroidism type ia: new evidence for imprinting of the Gs alpha gene
    Giovanna Mantovani
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, 20122 Milan, Italy
    J Clin Endocrinol Metab 88:4070-4. 2003
    ..In conclusion, we report that in addition to PTH and TSH resistance, patients with PHP Ia display variable degrees of GHRH resistance, consistent with Gs alpha imprinting in human pituitary...
  42. ncbi request reprint Vasopressin and desmopressin in central diabetes insipidus: adverse effects and clinical considerations
    Roy J Kim
    Division of Endocrinology R J K, T M, Department of Pediatrics, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Endocrinol Rev 2:115-23. 2004
    ..Herein we review the adverse effects of DDAVP and its predecessor, vasopressin, as well as discuss important clinical considerations when using these agents to treat central diabetes insipidus...
  43. ncbi request reprint Pituitary magnetic resonance imaging in idiopathic and genetic growth hormone deficiency
    Mohamad Maghnie
    J Clin Endocrinol Metab 88:1911; author reply 1911-2. 2003
  44. ncbi request reprint The diagnosis of children with central diabetes insipidus
    Stefano Ghirardello
    Institute of Pediatrics and Neonatology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Italy
    J Pediatr Endocrinol Metab 20:359-75. 2007
    ....
  45. ncbi request reprint Growth hormone in growth hormone deficiency. Deficiency cannot be diagnosed solely on the results of stimulation tests
    Sandro Loche
    BMJ 325:1037. 2002
  46. ncbi request reprint Inaccuracy of insulin-like growth factor (IGF) binding protein (IGFBP)-3 assessment in the diagnosis of growth hormone (GH) deficiency from childhood to young adulthood: association to low GH dependency of IGF-II and presence of circulating IGFBP-3 18-kil
    Stefano Cianfarani
    Rina Balducci Center of Pediatric Endocrinology, Department of Public Health and Cell Biology, Room E 178, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy
    J Clin Endocrinol Metab 90:6028-34. 2005
    ..Poor sensitivity of IGF binding protein (IGFBP)-3 assessment in the work-up of GH deficiency (GHD) has been ascribed to the equal affinity of IGFBP-3 for IGF-I and IGF-II and to IGFBP-3 proteolysis...