Mario Maggi

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi request reprint The burden of testosterone deficiency syndrome in adult men: economic and quality-of-life impact
    Mario Maggi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Sex Med 4:1056-69. 2007
  2. doi request reprint Testosterone partially ameliorates metabolic profile and erectile responsiveness to PDE5 inhibitors in an animal model of male metabolic syndrome
    Sandra Filippi
    University of Florence Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction Departments of Pharmacology and Clinical Physiopathology, Florence, Italy
    J Sex Med 6:3274-88. 2009
  3. pmc Metabolic syndrome and prostate abnormalities in male subjects of infertile couples
    Francesco Lotti
    Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
    Asian J Androl 16:295-304. 2014
  4. doi request reprint Dehydroepiandrosterone supplementation in elderly men: a meta-analysis study of placebo-controlled trials
    Giovanni Corona
    Endocrinology Unit, Medical Department, Azienda Unità Sanitaria Locale di Bologna, Maggiore Bellaria Hospital, 40133 Bologna, Italy
    J Clin Endocrinol Metab 98:3615-26. 2013
  5. doi request reprint Hormonal causes of male sexual dysfunctions and their management (hyperprolactinemia, thyroid disorders, GH disorders, and DHEA)
    Mario Maggi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 10:661-77. 2013
  6. doi request reprint Standard operating procedures: pubertas tarda/delayed puberty--male
    Mario Maggi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 10:285-93. 2013
  7. doi request reprint Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract
    Benedetta Fibbi
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:59-69. 2010
  8. doi request reprint Testosterone/estradiol ratio regulates NO-induced bladder relaxation and responsiveness to PDE5 inhibitors
    Linda Vignozzi
    Clinical Physiopathology, Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 9:3028-40. 2012
  9. ncbi request reprint Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes
    Linda Vignozzi
    Andrology Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    J Sex Med 4:620-30; discussion 631-32. 2007
  10. doi request reprint Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome
    Annamaria Morelli
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Steroid Biochem Mol Biol 132:80-92. 2012

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint The burden of testosterone deficiency syndrome in adult men: economic and quality-of-life impact
    Mario Maggi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Sex Med 4:1056-69. 2007
    ..Such associations can lead to substantial economic and quality-of-life implications, the magnitude of which remains largely unknown...
  2. doi request reprint Testosterone partially ameliorates metabolic profile and erectile responsiveness to PDE5 inhibitors in an animal model of male metabolic syndrome
    Sandra Filippi
    University of Florence Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction Departments of Pharmacology and Clinical Physiopathology, Florence, Italy
    J Sex Med 6:3274-88. 2009
    ..Metabolic syndrome (MetS) is a clustering of cardio-metabolic risk factors (hyperglycemia, hypertension, dyslipidemia, visceral fat accumulation) that is also associated with hypogonadism and erectile dysfunction (ED)...
  3. pmc Metabolic syndrome and prostate abnormalities in male subjects of infertile couples
    Francesco Lotti
    Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
    Asian J Androl 16:295-304. 2014
    ....
  4. doi request reprint Dehydroepiandrosterone supplementation in elderly men: a meta-analysis study of placebo-controlled trials
    Giovanni Corona
    Endocrinology Unit, Medical Department, Azienda Unità Sanitaria Locale di Bologna, Maggiore Bellaria Hospital, 40133 Bologna, Italy
    J Clin Endocrinol Metab 98:3615-26. 2013
    ..Age-related dehydroepiandrosterone (DHEA) deficiency has been associated with a broad range of biological abnormalities in males...
  5. doi request reprint Hormonal causes of male sexual dysfunctions and their management (hyperprolactinemia, thyroid disorders, GH disorders, and DHEA)
    Mario Maggi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 10:661-77. 2013
    ..Besides hypogonadism, other endocrine disorders have been associated with male sexual dysfunction (MSD)...
  6. doi request reprint Standard operating procedures: pubertas tarda/delayed puberty--male
    Mario Maggi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 10:285-93. 2013
    ..Delayed puberty (DP) is a condition characterized by the lack of sexual maturation in boys (testis volume <4 mL) at a chronological age that is 2.5 standard deviations above the mean age of puberty in a normal population...
  7. doi request reprint Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract
    Benedetta Fibbi
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:59-69. 2010
    ..PDE5 is highly expressed in rat and human bladder, where it regulates cyclic guanosine monophosphate (cGMP) degradation, muscle tone, and proliferation...
  8. doi request reprint Testosterone/estradiol ratio regulates NO-induced bladder relaxation and responsiveness to PDE5 inhibitors
    Linda Vignozzi
    Clinical Physiopathology, Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 9:3028-40. 2012
    ..Although bladder function regulation is similar among genders, no data are available on PDE5 expression and activity in female bladder...
  9. ncbi request reprint Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes
    Linda Vignozzi
    Andrology Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    J Sex Med 4:620-30; discussion 631-32. 2007
    ..The contractile RhoA/Rho-kinase (ROCK) signaling pathway is upregulated in penile tissue in animal models of experimental diabetes and has been proposed to contribute to diabetes-related erectile dysfunction (ED)...
  10. doi request reprint Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome
    Annamaria Morelli
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Steroid Biochem Mol Biol 132:80-92. 2012
    ..INT-747 showed the most marked effects in counteracting MetS-related RhoA/ROCK overactivity, thus opening novel therapeutic opportunities for this drug...
  11. doi request reprint Priapus is happier with Venus than with Bacchus
    Valentina Boddi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:2831-41. 2010
    ..The relationship between alcohol consumption and erectile function is still not completely clarified...
  12. ncbi request reprint Atorvastatin but not elocalcitol increases sildenafil responsiveness in spontaneously hypertensive rats by regulating the RhoA/ROCK pathway
    Benedetta Fibbi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, V le G Pieraccini, 6, 50139 Florence, Italy
    J Androl 29:70-84. 2008
    ..In conclusion, atorvastatin, but not elocalcitol, ameliorates sildenafil-induced penile erections in SHR, likely by interfering with RhoA/ROCK signaling within the penis...
  13. doi request reprint Vardenafil modulates bladder contractility through cGMP-mediated inhibition of RhoA/Rho kinase signaling pathway in spontaneously hypertensive rats
    Annamaria Morelli
    Department of Clinical Physiopathology, University of Florence, Italy
    J Sex Med 6:1594-608. 2009
    ..Phosphorylation/inactivation of RhoA by cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) activity has been described in vascular smooth muscle...
  14. doi request reprint Risk factors associated with primary and secondary reduced libido in male patients with sexual dysfunction
    Giovanni Corona
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence, Italy
    J Sex Med 10:1074-89. 2013
    ..Reduced libido is a symptom referring more to a reduction in sexual drive for sexual activity...
  15. doi request reprint Autoeroticism, mental health, and organic disturbances in patients with erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence Italy
    J Sex Med 7:182-91. 2010
    ..Masturbation is a common, but often neglected, male sexual behavior...
  16. doi request reprint Acute vardenafil administration improves bladder oxygenation in spontaneously hypertensive rats
    Annamaria Morelli
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:107-20. 2010
    ..In human bladder, phosphodiesterase type 5 (PDE5) is present not only in the muscular wall but also in the vascular beds, suggesting a role for PDE5 inhibitors in favoring bladder blood flow and tissue oxygenation...
  17. ncbi request reprint Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility
    Linda Vignozzi
    Department of Clinical Physiopathology, University of Florence, Italy
    Endocrinology 145:1823-34. 2004
    ..In conclusion, these findings indicate that OT might participate in inducing postorgasmic penile flaccidity and suggest a new role for estrogens in the male: regulation of CC responsiveness to OT...
  18. doi request reprint Atorvastatin ameliorates sildenafil-induced penile erections in experimental diabetes by inhibiting diabetes-induced RhoA/Rho-kinase signaling hyperactivation
    Annamaria Morelli
    University of Florence Andrology Unit, Department of Clinical Physiopathology, Florence, Italy
    J Sex Med 6:91-106. 2009
    ..One of the proposed mechanisms responsible for diabetes-related erectile dysfunction (ED) is overactivity of RhoA/ROCK signaling, as seen in experimental models of chemical diabetes...
  19. doi request reprint Sex steroid receptors in male human bladder: expression and biological function
    Aravinda K Chavalmane
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:2698-713. 2010
    ..Within the bladder, LUTS are linked to RhoA/Rho-kinase (ROCK) pathway overactivity...
  20. ncbi request reprint Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes
    Xin Hua Zhang
    Andrology Unit, Department of Clinical Physiopathology, Center of Research, Transfer and High Education, University of Florence, Florence, Italy
    J Sex Med 3:253-64; discussion 264-5, author reply 265-6. 2006
    ..Hypogonadism is often associated with diabetes and both conditions represent major risk factors for erectile dysfunction (ED)...
  21. doi request reprint Metabolic and cardiovascular outcomes of fatherhood: results from a cohort of study in subjects with sexual dysfunction
    Alessandra D Fisher
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 9:2785-94. 2012
    ..Up to now, no studies have evaluated these associations in a population of men seeking treatment for sexual dysfunction (SD)...
  22. ncbi request reprint Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa
    Annamaria Morelli
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    Endocrinology 145:2253-63. 2004
    ..In conclusion, we demonstrated, for the first time, that androgens positively regulate PDE5, thus providing a possible explanation about the highest abundance of this enzyme in male genital tract...
  23. doi request reprint PDE5 inhibitors blunt inflammation in human BPH: a potential mechanism of action for PDE5 inhibitors in LUTS
    Linda Vignozzi
    Department of Experimental and Clinical Biomedical Sciences, Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy
    Prostate 73:1391-402. 2013
    ..One proposed mechanism of action of PDE5 is the inhibition of intraprostatic inflammation. In this study we investigate whether PDE5i could blunt inflammation in the human prostate...
  24. doi request reprint Hormonal association and sexual dysfunction in patients with impaired fasting glucose: a cross-sectional and longitudinal study
    Giovanni Corona
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 9:1669-80. 2012
    ..The category of impaired fasting glucose (IFG) denotes a state of nondiabetic hyperglycemia, considered a risk factor for the further development of diabetes mellitus (DM) and cardiovascular (CV) diseases...
  25. ncbi request reprint Male sexuality and cardiovascular risk. A cohort study in patients with erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:1918-27. 2010
    ....
  26. doi request reprint Estrogens regulate humans and rabbit epididymal contractility through the RhoA/Rho-kinase pathway
    Benedetta Fibbi
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 6:2173-86. 2009
    ..Because RhoA/Rho-kinase (ROCK) pathway is a contractile effector downstream to both OT and ET-1 receptors, we hypothesized an estrogenic modulation of OT- and ET-1-induced contraction through the up-regulation of RhoA/ROCK signaling...
  27. ncbi request reprint Characterization and functional role of androgen-dependent PDE5 activity in the bladder
    Sandra Filippi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Endocrinology 148:1019-29. 2007
    ....
  28. doi request reprint Dihydrotestosterone and leptin regulate gonadotropin-releasing hormone (GnRH) expression and secretion in human GnRH-secreting neuroblasts
    Annamaria Morelli
    Andrology Unit, Department of Clinical Physiotherapy, University of Florence, Florence, Italy
    J Sex Med 6:397-407. 2009
    ....
  29. ncbi request reprint Oxytocin mediates the estrogen-dependent contractile activity of endothelin-1 in human and rabbit epididymis
    Sandra Filippi
    Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, University of Florence, 50139 Florence, Italy
    Endocrinology 146:3506-17. 2005
    ..Hence, we propose that an ET-1-induced OT/OTR system activation underlies the estrogen-dependent hyperresponsiveness to ET-1. These local sources might promote the spontaneous motility necessary for sperm transport...
  30. ncbi request reprint Effect of chronic tadalafil administration on penile hypoxia induced by cavernous neurotomy in the rat
    Linda Vignozzi
    Andrology Unit, Department of Clinical Physiopathology, Center of Research, Transfer and High Education, University of Florence, Florence, Italy
    J Sex Med 3:419-31. 2006
    ..Numerous men develop postprostatectomy erectile dysfunction (PPED), due to surgery-related nervous damage. PPED is often refractory to phosphodiesterase type 5 (PDE5) inhibitors therapy...
  31. doi request reprint Sociodemographic and clinical features of gender identity disorder: an Italian multicentric evaluation
    Alessandra D Fisher
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 10:408-19. 2013
    ..Currently, no descriptive studies focusing on MtFs and FtMs attending an Italian clinic are available...
  32. doi request reprint Fat boosts, while androgen receptor activation counteracts, BPH-associated prostate inflammation
    Linda Vignozzi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Prostate 73:789-800. 2013
    ..Metabolic syndrome (MetS) and benign prostate hyperplasia (BPH) are often comorbid. Chronic inflammation, a determinant pathogenic factor for BPH, is a putative link between the two conditions...
  33. doi request reprint A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia
    Mauro Gacci
    Department of Urology, University of Florence, Florence, Italy
    Eur Urol 61:994-1003. 2012
    ..However, the results are inconsistent...
  34. doi request reprint Hysterical traits are not from the uterus but from the testis: a study in men with sexual dysfunction
    Elisa Bandini
    University of Florence, Department of Clinical Physiopathology, Florence, Italy
    J Sex Med 6:2321-31. 2009
    ..The relationship between testosterone (T) and psychopathology in subjects with sexual dysfunction has not been completely clarified...
  35. doi request reprint Regulation of epididymal contractility during semen emission, the first part of the ejaculatory process: a role for estrogen
    Linda Vignozzi
    University of Florence Clinical Physiopathology, Andrology Unit, Florence, Italy
    J Sex Med 5:2010-6; quiz 2017. 2008
    ....
  36. doi request reprint Low levels of androgens in men with erectile dysfunction and obesity
    Giovanni Corona
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 5:2454-63. 2008
    ..The relationship between obesity and erectile dysfunction (ED) has not been completely clarified...
  37. doi request reprint Sex steroids and leptin regulate the "first Kiss" (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts
    Annamaria Morelli
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 5:1097-113. 2008
    ..GPR54 mutations cause hypogonadotropic hypogonadism in human and mice. Aim. Our aim was to study regulation of the KiSS-1/GPR54 system using a previously characterized primary culture of human fetal GnRH-secreting neuroblasts, FNC-B4...
  38. doi request reprint The relationship of testosterone to prostate-specific antigen in men with sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:284-92. 2010
    ..Concern about a testosterone (T)-induced prostate-specific antigen (PSA) increase is often perceived as one of the main limitations in treating hypogonadism even when it is symptomatic, such as in subjects with sexual dysfunction (SD)...
  39. ncbi request reprint BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder
    Annamaria Morelli
    Andrology Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education DENOthe, Univesity of Florence, Florence, Italy
    Prostate 67:234-47. 2007
    ..Because bladder smooth muscle cells express VDR, we studied effects of BXL-628 on this pathway...
  40. doi request reprint Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit
    Linda Vignozzi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
    J Endocrinol 212:71-84. 2012
    ..These data highlight that testosterone protects rabbit prostate from MetS-induced prostatic hypoxia, fibrosis, and inflammation, which can play a role toward the development/progression of BPH/LUTS...
  41. doi request reprint Pulse pressure independently predicts major cardiovascular events in younger but not in older subjects with erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 8:247-54. 2011
    ..We previously also reported a negative association between PP and arteriogenic erectile dysfunction (ED). This finding has recently been questioned...
  42. doi request reprint Serum PSA as a predictor of testosterone deficiency
    Giulia Rastrelli
    Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental, and Clinical Sciences, University of Florence, Florence, Italy
    J Sex Med 10:2518-28. 2013
    ..The relationship between serum prostate-specific antigen (PSA) and testosterone (T) levels is still controversial. According to the "saturation hypothesis," a significant relationship is apparent only in the low T range...
  43. doi request reprint The identification of prediabetes condition with ARIC algorithm predicts long-term CV events in patients with erectile dysfunction
    Giovanni Corona
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence, Italy
    J Sex Med 10:1114-23. 2013
    ..Recently, it has been shown to predict another relevant cardiovascular (CV) risk factor, such as chronic kidney disease...
  44. ncbi request reprint Effect of hyperprolactinemia in male patients consulting for sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 4:1485-93. 2007
    ..The physiological role of prolactin (PRL) in male sexual function has not been completely clarified...
  45. doi request reprint Impaired masturbation-induced erections: a new cardiovascular risk factor for male subjects with sexual dysfunction
    Giulia Rastrelli
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence, Italy
    J Sex Med 10:1100-13. 2013
    ..Although autoeroticism is a very common practice, data on masturbation-induced erections as a possible predictor of major adverse cardiovascular events (MACE) are lacking...
  46. ncbi request reprint The effect of statin therapy on testosterone levels in subjects consulting for erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence Italy
    J Sex Med 7:1547-56. 2010
    ..Previous clinical studies on effect of statins treatment on testosterone (T) levels have produced mixed results...
  47. doi request reprint Body mass index regulates hypogonadism-associated CV risk: results from a cohort of subjects with erectile dysfunction
    Giovanni Corona
    Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 8:2098-105. 2011
    ..Obesity is an independent cardiovascular (CV) risk factor. Testosterone (T) is inversely related to body mass index (BMI) in males. There is substantial evidence suggesting that low T could play a role as a moderator of CV mortality in men...
  48. doi request reprint Impairment of couple relationship in male patients with sexual dysfunction is associated with overt hypogonadism
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 6:2591-600. 2009
    ..Couple sexual dysfunction is a common, but not often studied, problem...
  49. ncbi request reprint NCEP-ATPIII-defined metabolic syndrome, type 2 diabetes mellitus, and prevalence of hypogonadism in male patients with sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Fiale Pieraccini 6, 50139 Florence, Italy
    J Sex Med 4:1038-45. 2007
    ..Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are characterized by insulin resistance and often associated with male hypogonadism...
  50. doi request reprint Cavernous neurotomy in the rat is associated with the onset of an overt condition of hypogonadism
    Linda Vignozzi
    Andrology Unit Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    J Sex Med 6:1270-83. 2009
    ..RRP-related ED occurs as a result of surgically elicited neuropraxia, leading to histological changes in the penis, including collagenization of smooth muscle and endothelial damage...
  51. doi request reprint Pulse pressure, an index of arterial stiffness, is associated with androgen deficiency and impaired penile blood flow in men with ED
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 6:285-93. 2009
    ..Pulse pressure (PP; i.e., the arithmetic difference between systolic and diastolic blood pressure) reflects arterial stiffness and has been suggested to be an independent cardiovascular risk factor...
  52. doi request reprint SIEDY scale 3, a new instrument to detect psychological component in subjects with erectile dysfunction
    Giovanni Corona
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence Italy
    J Sex Med 9:2017-26. 2012
    ..We previously developed and validated a structured interview (SIEDY) dealing with the organic (Scale 1), relational (Scale 2), and psychological (Scale 3) components of erectile dysfunction (ED)...
  53. ncbi request reprint The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells
    Sara Marchiani
    Department of Clinical Physiopathology, Andrology Unit, Center of Research, Transfer and High Education DENOthe, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy
    J Cancer Res Clin Oncol 132:408-16. 2006
    ..We have also evaluated the effect of the analogue on KGF stimulation of PI3K/AKT signaling pathway...
  54. doi request reprint Psychobiological correlates of women's sexual interest as perceived by patients with erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence Italy
    J Sex Med 7:2174-83. 2010
    ..No study has ever evaluated the specific impact of men's perception of women's sexual desire on male sexual function and lifestyle attitudes in ED subjects...
  55. doi request reprint Gender identity disorder and eating disorders: similarities and differences in terms of body uneasiness
    Elisa Bandini
    Andrology Unit, Department of Clinical Physiopathology, Florence University School of Medicine, Largo Brambilla 3, Florence, Italy
    J Sex Med 10:1012-23. 2013
    ..To detect similarities and differences between subgroups of GID subjects, on the basis of genotypic sex and transitional stage...
  56. doi request reprint Mechanism of action of phosphodiesterase type 5 inhibition in metabolic syndrome-associated prostate alterations: an experimental study in the rabbit
    Annamaria Morelli
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Prostate 73:428-41. 2013
    ....
  57. doi request reprint Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cells
    Linda Vignozzi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
    J Endocrinol 214:31-43. 2012
    ..In conclusion, our data demonstrate that DHT exerts an immune regulatory role on human prostatic stromal cells, inhibiting their potential to actively induce and/or sustain autoimmune and inflammatory responses...
  58. doi request reprint Poor response to alprostadil ICI test is associated with arteriogenic erectile dysfunction and higher risk of major adverse cardiovascular events
    Giulia Rastrelli
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 8:3433-45. 2011
    ..Intracavernous alprostadil injection (ICI) test has been considered useless in assessing the vascular status of subjects with erectile dysfunction (ED)...
  59. doi request reprint Is metabolic syndrome a useless category in subjects with high cardiovascular risk? Results from a cohort study in men with erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 8:504-11. 2011
    ....
  60. ncbi request reprint Identification, characterization and biological activity of oxytocin receptor in the developing human penis
    Linda Vignozzi
    Department of Clinical Physiopathology, Andrology and Endocrinology Unit, University of Florence, 50139 Florence, Italy
    Mol Hum Reprod 11:99-106. 2005
    ..Thus, OTR might represent an additional target for investigating human fetal MEG organogenesis...
  61. ncbi request reprint A comparison of NCEP-ATPIII and IDF metabolic syndrome definitions with relation to metabolic syndrome-associated sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 4:789-96. 2007
    ..Aim. To investigate the associations between these two recently proposed definitions of MetS with the relative risk of arteriogenic ED and hypogonadism in a large cohort of patients with male sexual dysfunction...
  62. doi request reprint Vardenafil can improve continence recovery after bilateral nerve sparing prostatectomy: results of a randomized, double blind, placebo-controlled pilot study
    Mauro Gacci
    Department of Urology, University of Florence, Careggi Hospital, Florence, Italy
    J Sex Med 7:234-43. 2010
    ..Several trials in men with ED and lower urinary tract symptoms associated with benign prostatic hyperplasia suggest that PDE5-I could improve both erectile function and urinary symptoms...
  63. doi request reprint Different testosterone levels are associated with ejaculatory dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 5:1991-8. 2008
    ..The role of testosterone (T) in pathogenesis of ejaculatory symptoms has not been completely clarified...
  64. doi request reprint Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis
    Giovanni Corona
    Sexual Medicine Andrology Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy
    Eur J Endocrinol 168:829-43. 2013
    ..The aim of this study is to perform a systematic review and meta-analysis of available trials on the effect of body weight loss on sex hormones levels...
  65. doi request reprint Selective serotonin reuptake inhibitor-induced sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    J Sex Med 6:1259-69. 2009
    ..Sexual dysfunctions are often present in subjects with mood disturbances; however. antidepressants can induce per se sexual dysfunctions...
  66. doi request reprint Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study
    Giovanni Corona
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur J Endocrinol 165:687-701. 2011
    ..To verify whether hypogonadism represents a risk factor for cardiovascular (CV) morbidity and mortality and to verify whether testosterone replacement therapy (TRT) improves CV parameters in subjects with known CV diseases (CVDs)...
  67. doi request reprint A randomized, placebo-controlled study to assess safety and efficacy of vardenafil 10 mg and tamsulosin 0.4 mg vs. tamsulosin 0.4 mg alone in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia
    Mauro Gacci
    Department of Urology, University of Florence, Florence, Italy
    J Sex Med 9:1624-33. 2012
    ..Safety and efficacy of tamsulosin and vardenafil are well established: however, there is no report regarding combined therapy with these drugs for lower urinary tract symptoms (LUTSs) secondary to benign prostatic hyperplasia (BPH)...
  68. doi request reprint Phosphodiesterase type 5 expression in human and rat lower urinary tract tissues and the effect of tadalafil on prostate gland oxygenation in spontaneously hypertensive rats
    Annamaria Morelli
    Department of Clinical Physiopathology, Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 8:2746-60. 2011
    ....
  69. ncbi request reprint The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms
    Francesco Lotti
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    J Sex Med 6:2878-87. 2009
    ..No study has ever systematically evaluated the impact of varicocele on sexual function...
  70. doi request reprint The vitamin D receptor agonist elocalcitol upregulates L-type calcium channel activity in human and rat bladder
    Annamaria Morelli
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Am J Physiol Cell Physiol 294:C1206-14. 2008
    ....
  71. doi request reprint Testosterone and metabolic syndrome: a meta-analysis study
    Giovanni Corona
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 8:272-83. 2011
    ..Metabolic syndrome (MetS) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone replacement therapy (TRT) in MetS has not been completely clarified...
  72. ncbi request reprint Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS)
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:1362-80. 2010
    ..Limited information is available concerning the general and sexual health status of European men...
  73. doi request reprint Psychobiological correlates of extramarital affairs and differences between stable and occasional infidelity among men with sexual dysfunctions
    Alessandra D Fisher
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 6:866-75. 2009
    ..The relationship between extramarital affairs and male sexual dysfunctions (SDs) has not been completely clarified...
  74. ncbi request reprint ANDROTEST: a structured interview for the screening of hypogonadism in patients with sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 3:706-15. 2006
    ....
  75. ncbi request reprint Testosterone regulates PDE5 expression and in vivo responsiveness to tadalafil in rat corpus cavernosum
    Xin Hua Zhang
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, V le G Pieraccini, 6, 50139 Florence, Italy
    Eur Urol 47:409-16; discussion 416. 2005
    ..To investigate the effect of testosterone on PDE5 expression and PDE5 inhibitor tadalafil in vivo responsiveness in a rat model...
  76. doi request reprint Perceived reduced sleep-related erections in subjects with erectile dysfunction: psychobiological correlates
    Giovanni Corona
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 8:1780-8. 2011
    ..However, the clinical correlates of PR-SREs have not been thoroughly investigated...
  77. doi request reprint Severe depressive symptoms and cardiovascular risk in subjects with erectile dysfunction
    Elisa Bandini
    University of Florence Andrology Unit, Department of Clinical Physiopathology, Florence, Italy
    J Sex Med 7:3477-86. 2010
    ..Erectile dysfunction (ED) and mood depression are often associated and both are correlated with an increased risk of cardiovascular morbidity and mortality...
  78. ncbi request reprint Psychobiologic correlates of the metabolic syndrome and associated sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Eur Urol 50:595-604; discussion 604. 2006
    ....
  79. doi request reprint Sexual and cardiovascular correlates of male unfaithfulness
    Alessandra D Fisher
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 9:1508-18. 2012
    ..Therefore, the study of this sensitive topic is extremely complex, and its prevalence is often underestimated...
  80. doi request reprint Hypoprolactinemia: a new clinical syndrome in patients with sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 6:1457-66. 2009
    ..The physiological role of prolactin (PRL) in male sexual behavior is poorly understood. Conversely, the association between PRL pathological elevation in both reproductive and sexual behavior is well defined...
  81. ncbi request reprint Low testosterone is associated with an increased risk of MACE lethality in subjects with erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:1557-64. 2010
    ....
  82. ncbi request reprint The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin
    Alessandro Peri
    Department of Clinical Physiopathology, Endocrine Unit, University of Florence, Italy
    Hum Cell 16:95-9. 2003
  83. doi request reprint Testosterone, cardiovascular disease and the metabolic syndrome
    Giovanni Corona
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Best Pract Res Clin Endocrinol Metab 25:337-53. 2011
    ..A meta-analysis on the effect of TRT in MetS-associated hypogonadism demonstrated positive effects of T on some of the components of MetS. Large-scale interventional studies with TRT are therefore advisable...
  84. ncbi request reprint Association between psychiatric symptoms and erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Italy
    J Sex Med 5:458-68. 2008
    ..Erectile dysfunction (ED) is often associated with a wide array of psychiatric symptoms, although few studies systematically address their specific association with ED determinants...
  85. ncbi request reprint Six-month administration of 1% testosterone gel is able to restore erectile function in hypogonadal patients with erectile dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Arch Ital Urol Androl 80:103-8. 2008
    ..The purpose of the present study was to evaluate the efficacy and safety of a 50 mg/day of 1% hydroalcoholic testosterone gel applied on non-scrotal skin for hypogonadal men with sexual dysfunction...
  86. doi request reprint Farnesoid X receptor activation improves erectile function in animal models of metabolic syndrome and diabetes
    Linda Vignozzi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 8:57-77. 2011
    ..The farnesoid X receptor (FXR) is critically involved in the regulation of the hepato-biliary system. Recent data suggest a role for FXR in modulating other metabolic pathways and vascular function...
  87. ncbi request reprint Human bladder as a novel target for vitamin D receptor ligands
    Clara Crescioli
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Clin Endocrinol Metab 90:962-72. 2005
    ....
  88. ncbi request reprint Assessment of the relational factor in male patients consulting for sexual dysfunction: the concept of couple sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, Diabetes Section, Viale Pieraccini 6, Florence, Italy
    J Androl 27:795-801. 2006
    ..Resolving, or at least ameliorating, the relational background and the sexual framework might help in treating male sexual dysfunction...
  89. ncbi request reprint Vardenafil improves urodynamic parameters in men with spinal cord injury: results from a single dose, pilot study
    Mauro Gacci
    Urology Unit, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
    J Urol 178:2040-3; discussion 2044. 2007
    ..We assessed urodynamic changes after vardenafil administration in spinal cord injured male patients on oxybutynin treatment...
  90. ncbi request reprint Role of endothelin-1 in the migration of human olfactory gonadotropin-releasing hormone-secreting neuroblasts
    Roberto G Romanelli
    Department of Anatomy Histology and Forensic Medicine, University of Florence, I 50134 Florence, Italy
    Endocrinology 146:4321-30. 2005
    ..The coordinate interaction between ET receptors and GnRH receptor participates in the fully expressed GnRH-secreting neuron phenotype...
  91. doi request reprint Penile doppler ultrasound in patients with erectile dysfunction (ED): role of peak systolic velocity measured in the flaccid state in predicting arteriogenic ED and silent coronary artery disease
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 5:2623-34. 2008
    ..The use of the penile peak systolic velocity (PSV) measured in the flaccid state during penile color Doppler ultrasound (PCDU) examination has been questioned without substantial evidence...
  92. doi request reprint Perceived ejaculate volume reduction in patients with erectile dysfunction: psychobiologic correlates
    Giovanni Corona
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Androl 32:333-9. 2011
    ..Our results indicate that PEVR is important not only for couple reproductive purposes but also appears to have a distinct role in the couple's sexual performance...
  93. ncbi request reprint Origin and biological significance of DNA fragmentation in human spermatozoa
    Monica Muratori
    Department of Clinical Physiopathology, Center for Research, Transfer and High Education, DENOthe, University of Florence, Viale Pieraccini, 6, I 50139 Florence, Italy
    Front Biosci 11:1491-9. 2006
    ....
  94. doi request reprint Prostate cancer: a model of integration of genomic and non-genomic effects of the androgen receptor in cell lines model
    Lorella Bonaccorsi
    Department of Clinical Physiopathology, Andrology Unit, Viale Pieraccini 6, I 50139 Florence, Italy
    Steroids 73:1030-7. 2008
    ..Our data enlighten that the crosstalk between genotropic and non-genotropic AR signalling interferes with signalling of EGFR in response to ligand leading to a lower invasive phenotype of AR-positive PCa cells...
  95. ncbi request reprint Spontaneous DNA fragmentation in swim-up selected human spermatozoa during long term incubation
    Monica Muratori
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    J Androl 24:253-62. 2003
    ..These findings suggest an involvement of endogenously produced reactive oxygen species as the possible cause of in vitro sperm DNA fragmentation...
  96. ncbi request reprint Estrogens, but not androgens, regulate expression and functional activity of oxytocin receptor in rabbit epididymis
    Sandra Filippi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    Endocrinology 143:4271-80. 2002
    ..Blocking aromatase activity almost completely abolished OT sensitivity. These findings suggest a new function of estrogens in the male: regulation of OT responsiveness in epididymis...
  97. ncbi request reprint Health-related quality of life instruments in studies of adult men with testosterone deficiency syndrome: a critical assessment
    Sue Langham
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 5:2842-52. 2008
    ..This information is becoming increasingly important in policy and clinical decisions. With such a wide range of tools available, careful selection is required to ensure they adequately reflect patient's concerns...
  98. ncbi request reprint Prognostic value of somatostatin receptor subtype 2 expression in colorectal cancer
    Claudia Casini Raggi
    Clinical Biochemistry, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence, Italy
    Regul Pept 132:23-6. 2005
    ....
  99. ncbi request reprint Vitamin D3 analogue inhibits keratinocyte growth factor signaling and induces apoptosis in human prostate cancer cells
    Clara Crescioli
    Department of Clinical Physiopathology, Endocrinology Unit, University of Florence, Florence, Italy
    Prostate 50:15-26. 2002
    ..Hence, there is the need of new treatment opportunities targeting androgen-independent, growth factor-mediated, tumor signaling. One of these new promising opportunities is vitamin D3 and its related analogues...