M Maggi

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi Erectile dysfunction: from biochemical pharmacology to advances in medical therapy
    M Maggi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Italy
    Eur J Endocrinol 143:143-54. 2000
  2. ncbi Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinic
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 18:190-7. 2006
  3. ncbi Difficulties in achieving vs maintaining erection: organic, psychogenic and relational determinants
    G Corona
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    Int J Impot Res 17:252-8. 2005
  4. ncbi Psychobiological correlates of smoking in patients with erectile dysfunction
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 17:527-34. 2005
  5. ncbi Effect of sildenafil administration on penile hypoxia induced by cavernous neurotomy in the rat
    L Vignozzi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 20:60-7. 2008
  6. doi Elevated body mass index correlates with higher seminal plasma interleukin 8 levels and ultrasonographic abnormalities of the prostate in men attending an andrology clinic for infertility
    F Lotti
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Endocrinol Invest 34:e336-42. 2011
  7. doi The age-related decline of testosterone is associated with different specific symptoms and signs in patients with sexual dysfunction
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 32:720-8. 2009
  8. ncbi The impotent couple: low desire
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence Italy
    Int J Androl 28:46-52. 2005
  9. ncbi Identification, localization and functional in vitro and in vivo activity of oxytocin receptor in the rat penis
    X H Zhang
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Endocrinol 184:567-76. 2005
  10. ncbi Frequency of sexual activity and cardiovascular risk in subjects with erectile dysfunction: cross-sectional and longitudinal analyses
    G Corona
    Sexual Medicine and Andrology Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy Endocrinology Unit, Medical Department, Azienda USL, Maggiore Bellaria Hospital, Bologna, Italy
    Andrology 1:864-71. 2013

Collaborators

Detail Information

Publications76

  1. ncbi Erectile dysfunction: from biochemical pharmacology to advances in medical therapy
    M Maggi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Italy
    Eur J Endocrinol 143:143-54. 2000
    ....
  2. ncbi Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinic
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 18:190-7. 2006
    ..Our results show that hypogonadism is frequently associated with type II DM, at least in the 6th decade. DMAH might exacerbate sexual dysfunction by reducing libido and mood and further compromising penile vascular reactivity...
  3. ncbi Difficulties in achieving vs maintaining erection: organic, psychogenic and relational determinants
    G Corona
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    Int J Impot Res 17:252-8. 2005
    ....
  4. ncbi Psychobiological correlates of smoking in patients with erectile dysfunction
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 17:527-34. 2005
    ..Our report demonstrates that smoking has a strong negative impact on male sexual life, even if it is associated at an apparently more sexual-favourable hormonal milieu...
  5. ncbi Effect of sildenafil administration on penile hypoxia induced by cavernous neurotomy in the rat
    L Vignozzi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 20:60-7. 2008
    ..Sildenafil treatment was able to counteract all these alterations (penile hypoxygenation, hyper-sensitivity to IRL-1620 and ETB overexpression), with its effect being more evident the earlier it was administered...
  6. doi Elevated body mass index correlates with higher seminal plasma interleukin 8 levels and ultrasonographic abnormalities of the prostate in men attending an andrology clinic for infertility
    F Lotti
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Endocrinol Invest 34:e336-42. 2011
    ....
  7. doi The age-related decline of testosterone is associated with different specific symptoms and signs in patients with sexual dysfunction
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 32:720-8. 2009
    ..In particular, low T is associated with sexual dysfunction more often in the oldest subjects...
  8. ncbi The impotent couple: low desire
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence Italy
    Int J Androl 28:46-52. 2005
    ..In conclusion, HSD is associated with several biological, psychological, and relational factors that can be simultaneously identified and quantified using the SIEDY structured interview...
  9. ncbi Identification, localization and functional in vitro and in vivo activity of oxytocin receptor in the rat penis
    X H Zhang
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Endocrinol 184:567-76. 2005
    ..05 vs control), but not at the maximal frequency (16 Hz). Our data showed that OTR is present in the rat penis and mediates contractility both in vitro and in vivo, therefore suggesting a role for OT in maintaining penile detumescence...
  10. ncbi Frequency of sexual activity and cardiovascular risk in subjects with erectile dysfunction: cross-sectional and longitudinal analyses
    G Corona
    Sexual Medicine and Andrology Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy Endocrinology Unit, Medical Department, Azienda USL, Maggiore Bellaria Hospital, Bologna, Italy
    Andrology 1:864-71. 2013
    ..Identifying among mild-to-moderate ED subjects those with lower frequency of sexual activity might provide an opportunity to modify their behaviour and to discover subthreshold comorbidities, possibly preventing forthcoming CV events. ..
  11. ncbi Sexual dysfunction in subjects with Klinefelter's syndrome
    G Corona
    Andrology Unit and Endocrinology Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    Int J Androl 33:574-80. 2010
    ..Further studies are needed to evaluate the efficacy of testosterone substitution in ameliorating the hypoactive sexual desire often reported in subjects with KS...
  12. doi Clinical implications of measuring prolactin levels in males of infertile couples
    F Lotti
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Italy
    Andrology 1:764-71. 2013
    ..We report a positive association among PRL and ejaculate and SV volume, before and after ejaculation. Low PRL is associated with a lessened ability to control ejaculation. ..
  13. ncbi Peripheral regulatory mechanisms in erection
    A Morelli
    Andrology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Int J Androl 28:23-7. 2005
    ....
  14. doi Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples
    F Lotti
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Andrology 1:229-39. 2013
    ..Recognizing MetS could help patients to improve not only fertility but also sexual and overall health...
  15. ncbi Gene expression of endothelin-1, endothelin-converting enzyme-1, and endothelin receptors in human epididymis
    A Peri
    Endocrinology Unit, University of Florence, Italy
    J Clin Endocrinol Metab 82:3797-806. 1997
    ..These receptors mediate the contractile activity of the epididymis in vitro, thus suggesting that ET-1 can be responsible of sperm progression through this organ, acting via a paracrine mode of action...
  16. ncbi Effects of NCX 4050, a new NO donor, in rabbit and human corpus cavernosum
    S Filippi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Int J Androl 26:101-8. 2003
    ..Our results provide a rationale for a possible future use of NCX 4050 in the pharmacotherapy of erectile dysfunction linked to an impaired release of NO from the endothelium...
  17. ncbi Expression of functional estrogen receptors in human fetal male external genitalia
    C Crescioli
    Department of Clinical Physiopathology, Endocrinology Unit, University of Florence, Italy
    J Clin Endocrinol Metab 88:1815-24. 2003
    ....
  18. doi Seminal vesicles ultrasound features in a cohort of infertility patients
    F Lotti
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
    Hum Reprod 27:974-82. 2012
    ..The aim of this study was to evaluate the volume and the emptying characteristics of the SV and their possible correlations with scrotal and transrectal ultrasound features...
  19. ncbi Aging and pathogenesis of erectile dysfunction
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 16:395-402. 2004
    ..A better understanding of the relative contribution of age-related pathogenetic factors of ED could be of help in the design of appropriate therapeutic approaches...
  20. ncbi Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasia
    C Crescioli
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Eur J Endocrinol 150:591-603. 2004
    ..We here report the preclinical characterization of BXL-628, an analogue selected for an ongoing double-blind, randomized, placebo-controlled phase II trial in BPH...
  21. ncbi Chronic inflammation in the pathogenesis of benign prostatic hyperplasia
    B Fibbi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 33:475-88. 2010
    ..The mechanism of action of VDR agonists supports an important role of chronic inflammation in BPH pathogenesis and strengthens the concept of these agents as a therapeutic option for pharmacological treatment of BPH...
  22. ncbi Sex steroid modulation of neurohypophysial hormone receptors in human nonpregnant myometrium
    M Maggi
    Department of Clinical Physiopathology, University of Florence, Italy
    J Clin Endocrinol Metab 74:385-92. 1992
    ..Furthermore, they imply that neurohypophysial hormones are involved in the control of uterine activity during the menstrual cycle...
  23. doi Premature and delayed ejaculation: two ends of a single continuum influenced by hormonal milieu
    G Corona
    Department of Clinical Physiopathology, Andrology Unit and Endocrinology, University of Florence, Florence, Italy
    Int J Androl 34:41-8. 2011
    ..056, 0.047 and -0.059 for PRL, TSH and testosterone, respectively; all p < 0.05). This study indicates endocrine system is involved in the control of ejaculatory function and that PRL, TSH and testosterone play an independent role...
  24. doi Inhibitors of 5α-reductase-related side effects in patients seeking medical care for sexual dysfunction
    G Corona
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Endocrinol Invest 35:915-20. 2012
    ..However, the real impact of 5ARI on sex hormones and sexual function is controversial...
  25. doi Semen apoptotic M540 body levels correlate with testis abnormalities: a study in a cohort of infertile subjects
    F Lotti
    Department of Clinical Physiopathology, Sexual Medicine and Andrology and Endocrinology Units, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Hum Reprod 27:3393-402. 2012
    ..What are the associations between semen apoptotic M540 bodies and other parameters of semen quality and sonographic alterations of the male genital tract in a cohort of infertile subjects?..
  26. ncbi Testosterone and sexual activity
    L Vignozzi
    Andrology Unit, Department of Physiopathology, University of Florence, Florence, Italy
    J Endocrinol Invest 28:39-44. 2005
    ..In fact, penile erections are often present even without T. The main action of T is to timely adjust the erectile process as a function of sexual desire, therefore finalizing erections to sex...
  27. ncbi Effects of hypoxia on endothelin-1 sensitivity in the corpus cavernosum
    S Filippi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Italy
    Mol Hum Reprod 9:765-74. 2003
    ....
  28. ncbi Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens
    R Mancina
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, 50139, Florence, Italy
    Mol Hum Reprod 11:107-15. 2005
    ..Our results provide a hypothesis explaining the beneficial effects of PDE inhibitors in patients with rapid ejaculation...
  29. ncbi Psycho-biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions
    G Corona
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur Urol 46:615-22. 2004
    ....
  30. doi Diagnosis and treatment of late-onset hypogonadism: systematic review and meta-analysis of TRT outcomes
    G Corona
    Sexual Medicine and Andrology Unit Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy Endocrinology Unit, Maggiore Bellaria Hospital, Medical Department, Azienda USL Bologna, Bologna, Italy
    Best Pract Res Clin Endocrinol Metab 27:557-79. 2013
    ..However, it should be recognized that the number of studies on benefits of T supplementation is too limited to draw final conclusions. Longer and larger studies are needed to better clarify the role of TRT in such chronic conditions. ..
  31. ncbi Endothelin-1 production by prostate cancer cell lines is up-regulated by factors involved in cancer progression and down-regulated by androgens
    S Granchi
    Department of Clinical Physiopathology, Unit of Andrology, University of Florence, Florence, Italy
    Prostate 49:267-77. 2001
    ..In view of the role exerted by ET-1 in the process of bone metastasis, our data suggest the use of ET-1 receptor antagonists in the treatment of advanced prostate cancer...
  32. ncbi Pre-clinical evidence and clinical translation of benign prostatic hyperplasia treatment by the vitamin D receptor agonist BXL-628 (Elocalcitol)
    M Maggi
    Department of Clinical Physiopathology, Center of Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    J Endocrinol Invest 29:665-74. 2006
    ..The pronounced effects of BXL-628 on bladder smooth muscle cells and its anti-inflammatory properties indeed anticipate beneficial effects also on BPH-related lower urinary tract symptoms...
  33. doi Testosterone and cardiovascular risk in patients with erectile dysfunction
    G Corona
    Sexual Medicine and Andrology and Unit, Department of Clinical Physiopathology, University of Florence, Italy
    J Endocrinol Invest 35:809-16. 2012
    ..The relationship between cardiovascular (CV) diseases (CVD) and testosterone (T) levels in men has not been completely clarified...
  34. doi Type 2 diabetes mellitus and testosterone: a meta-analysis study
    G Corona
    Andrology Unit and Endocrinology, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 34:528-40. 2011
    ..Although only few RCTs have been reported, TRT seems to improve glycometabolic control as well as fat mass in T2DM subjects...
  35. doi Hypogonadism and metabolic syndrome
    G Corona
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Endocrinol Invest 34:557-67. 2011
    ..The relationship between metabolic syndrome (MetS), male hypogonadism and their possible interaction in cardiovascular (CV) risk stratification are not completely understood...
  36. ncbi Erectile dysfunction: molecular biology, pathophysiology and pharmacological treatment
    A Morelli
    Andrology Unit, Department of Clinical Pathophysiology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Minerva Urol Nefrol 57:85-90. 2005
    ..In conclusion, a better understanding of the pathogenic factors of ED will be useful to appropriately design pharmacotherapy and improve clinical management depending on the unique condition of each patient...
  37. ncbi Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells
    M Maggi
    Department of Clinical Physiopathology, University of Florence, Italy
    Regul Pept 56:175-84. 1995
    ..In neuroblastoma cells, AII does not stimulate DNA synthesis, suggesting other roles rather than mitogenesis. Neuroblastoma cells represents an interesting model to investigate the function of AII in neural crest derived tissues...
  38. doi Stable extramarital affairs are breaking the heart
    A D Fisher
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 35:11-7. 2012
    ..Therefore, infidelity induces not only heart trouble in the betrayed partners, but seems to be also able to increase the betrayer's heart-related events...
  39. ncbi Somatostatin receptor type 2 gene expression in neuroblastoma, measured by competitive RT-PCR, is related to patient survival and to somatostatin receptor imaging by indium -111-pentetreotide
    C Orlando
    Dep of Clinical Physiopathology, University of Florence, Italy
    Med Pediatr Oncol 36:224-6. 2001
    ..We also found that high level of sst2 expression were positively related to patient survival...
  40. ncbi Psycho-biological correlates of hypoactive sexual desire in patients with erectile dysfunction
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 16:275-81. 2004
    ..In conclusion, HSD in ED is associated with several biological, psychological, and relational factors that can be simultaneously identified and quantified using the SIEDY structured interview...
  41. doi Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation
    P Comeglio
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, V le Pieraccini 6, 50139 Florence, Italy
    J Endocrinol Invest 33:730-8. 2010
    ..Prostatic urethra actively participates in determining progression of LUTS associated with BPH...
  42. ncbi Cardiovascular risk engines can help in selecting patients to be evaluated by dynamic penile color doppler ultrasound
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Endocrinol Invest 31:1058-62. 2008
    ..Estimated cardiovascular risk, assessed through risk engines, could be used to identify patients who should undergo D-PCDU evaluation for the diagnosis of AED...
  43. doi Opposite effects of tamoxifen on metabolic syndrome-induced bladder and prostate alterations: a role for GPR30/GPER?
    P Comeglio
    Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
    Prostate 74:10-28. 2014
    ..In addition to ERs, GPR30/GPER is able to mediate several estrogenic non-genomic actions...
  44. ncbi Inhibition of spontaneous and androgen-induced prostate growth by a nonhypercalcemic calcitriol analog
    C Crescioli
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Endocrinology 144:3046-57. 2003
    ..BXL-353 and other vitamin D(3) analogs might thus represent an interesting class of compounds for treating patients with BPH...
  45. doi Seminal, clinical and colour-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples
    F Lotti
    Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
    Andrology 2:30-41. 2014
    ..In conclusion, NIH-CPSI scores and PLS evaluated in males of infertile couples, are not related to sperm parameters, but mainly to clinical and CDU signs of infection/inflammation. ..
  46. ncbi Endothelin-1: a new autocrine/paracrine factor in rat testis
    G Fantoni
    Department of Clinical Physiopathology, University of Florence, Italy
    Am J Physiol 265:E267-74. 1993
    ..Specific 125I-ET-1 binding sites are present also in Sertoli cells but are 50-fold less concentrated than in Leydig cells. Our results suggest an autocrine/paracrine role for ET-1 in rat testis...
  47. ncbi Type-2 somatostatin receptor mRNA levels in breast and colon cancer determined by a quantitative RT-PCR assay based on dual label fluorogenic probe and the TaqMan technology
    P Pinzani
    Clinical Biochemistry, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    Regul Pept 99:79-86. 2001
    ..For a correct evaluation of sst2 mRNA expression, it seems very important to measure the sst2 expression both in tumor and in the non-tumoral non-adjacent tumor specimens...
  48. doi Prolactin levels independently predict major cardiovascular events in patients with erectile dysfunction
    G Corona
    Andrology Unit and Endocrinology, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 34:217-24. 2011
    ..In subjects at high risk for cardiovascular diseases, such as those with ED, a relatively high PRL plasma level is associated with an overall decreased chance of MACE, independently from other known risk factors...
  49. pmc Influence of serum testosterone on urinary continence and sexual activity in patients undergoing radical prostatectomy for clinically localized prostate cancer
    M Gacci
    Department of Urology, University of Florence, Careggi Hospital, Florence, Italy
    Prostate Cancer Prostatic Dis 13:168-72. 2010
    ..The correlation between basal T and preoperative erectile function and urinary continence underlines the importance of assessing T before RP...
  50. doi Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 32:587-98. 2009
    ....
  51. ncbi Organic, relational and psychological factors in erectile dysfunction in men with diabetes mellitus
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur Urol 46:222-8. 2004
    ..The aim of the present study is to determine the contribution of organic, relational, and intrapsychic components to the pathogenesis of ED in diabetic in comparison with non-diabetic patients...
  52. doi Investigation on psychological symptoms improves ANDROTEST accuracy in predicting hypogonadism in subjects with sexual dysfunction
    G Rastrelli
    Department of Clinical Physiopathology, Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy
    Int J Impot Res 25:34-9. 2013
    ..05) alone. Hence, combining these two psychological symptoms with a physical scoring system improves its ability in detecting hypogonadism. The combination of the scores should be tested in other studies...
  53. doi Metabolic syndrome and lower urinary tract symptoms: the role of inflammation
    M Gacci
    Department of Urology, Careggi Hospital, University of Florence, Florence, Italy
    Prostate Cancer Prostatic Dis 16:101-6. 2013
    ..Aim of study is to examine the correlation among pre-operatory LUTS/BPH severity, MetS features and inflammatory infiltrates in prostatectomy specimens...
  54. ncbi Which patients with sexual dysfunction are suitable for testosterone replacement therapy?
    A Morelli
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Endocrinol Invest 30:880-8. 2007
    ..However, suspecting LOH/TDS in SD patients is not an easy task. Recently published structured inventories, such as ANDROTEST, might help physicians to recognize hypogonadism and to further pursue its appropriate diagnosis and treatment...
  55. doi Androgen-responsive and -unresponsive prostate cancer cell lines respond differently to stimuli inducing neuroendocrine differentiation
    S Marchiani
    Department of Clinical Physiopathology Andrology, University of Florence, Florence, Italy
    Int J Androl 33:784-93. 2010
    ..CaP cell lines did not respond univocally to treatments inducing NED, suggesting that studies on this topic should be performed in a wide spectrum of cell models which can be more indicative of the tumour variability in vivo...
  56. ncbi Somatostatin receptors and breast cancer
    M Cameron Smith
    Department of Endocrinology, University of Florence, Florence, Italy
    J Endocrinol Invest 26:125-30. 2003
  57. doi Childhood maltreatment in subjects with male-to-female gender identity disorder
    E Bandini
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 23:276-85. 2011
    ..The presence of reported CM in these patients has relevant psychopathological implications, and therefore should be carefully investigated...
  58. ncbi Is obesity a further cardiovascular risk factor in patients with erectile dysfunction?
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 7:2538-46. 2010
    ..Reduced penile blood flow is more common in obese people than in leaner ED subjects...
  59. ncbi Male pubertal development: role of androgen therapy on bone mass and body composition
    L Vignozzi
    Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence, Italy
    J Endocrinol Invest 33:27-32. 2010
    ..However, also genetic variants of genes involved in bone metabolism as well as in osteoblast/osteoclast activation are associated to bone mineral density...
  60. ncbi Role of oxytocin in the ejaculatory process
    S Filippi
    Andrology Unit, Department of Clinical Physiopathology, University of Firenze, Firenze, Italy
    J Endocrinol Invest 26:82-6. 2003
    ..These findings suggest a new function of estrogens in the male: regulation of OT responsiveness in epididymis...
  61. doi Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function
    L Vignozzi
    Sexual Medicine and Andrology Unit, Endocrinology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Mol Hum Reprod 16:418-24. 2010
    ..In conclusion, androgen deficiency more than chromosomal abnormality is the major pathogenic factor of sexual dysfunction in KS...
  62. ncbi Expression and regulation of endothelin-1 and its receptors in human penile smooth muscle cells
    S Granchi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    Mol Hum Reprod 8:1053-64. 2002
    ..In addition, the hfPSMC we have characterized might be a useful model for studying biochemical aspects of the human erectile process in vitro...
  63. ncbi Measurement of somatostatin receptor subtype 2 mRNA in breast cancer and corresponding normal tissue
    C Orlando
    Clinical Biochemistry Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Endocr Relat Cancer 11:323-32. 2004
    ..Featuring a possible role of somatostatin analogs in combined endocrine therapies for breast cancer, our results seem to confirm that the sst2 status of the tumor should be previously investigated...
  64. doi Following the common association between testosterone deficiency and diabetes mellitus, can testosterone be regarded as a new therapy for diabetes?
    G Corona
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 32:431-41. 2009
    ..In addition, we have also reviewed available evidence on potential metabolic benefits of testosterone supplementation in T2DM patients...
  65. ncbi Sex steroid modulation of AT2 receptors in human myometrium
    R Mancina
    Department of Clinical Physiopathology and Andrology, University of Florence, Italy
    J Clin Endocrinol Metab 81:1753-7. 1996
    ..Hence, these data confirm the presence of AT2 receptors in human uterus and indicate their regulation by sex steroids...
  66. doi Klinefelter's syndrome: a clinical and therapeutical update
    G Forti
    Endocrinology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Sex Dev 4:249-58. 2010
    ..Furthermore, the genetic risk to the offspring of Klinefelter patients has recently not been found to be greater than that of patients with nonobstructive azoospermia with normal karyotype...
  67. ncbi Pharmacological profile of MEN 11066, a novel potent and selective aromatase inhibitor
    M Muratori
    Department of Clinical Physiopathology, University of Florence, V le Pieraccini 6, I 50139 Firenze, Italy
    J Steroid Biochem Mol Biol 84:503-12. 2003
    ..These results demonstrated that MEN 11066 is a potent inhibitor of aromatase which does not interfere with the cytochrome P450 involved in the synthesis of other steroids or in the metabolism of xenobiotics...
  68. doi Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility
    F Lotti
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 34:600-13. 2011
    ..Furthermore, sIL-8 positively correlates with CDU signs of ejaculatory duct inflammatory subobstruction...
  69. doi Androgen regulation of prostate cancer: where are we now?
    G Corona
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Endocrinol Invest 34:232-43. 2011
    ..Androgens play an essential role in the development and differentiation of the prostate gland; their contribution to pathological conditions, such as benign prostatic hyperplasia and prostate cancer (PC), remains unclear...
  70. ncbi Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation
    S Filippi
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    Int J Impot Res 14:295-307. 2002
    ..Our data indicate that the relaxant effect of yohimbine is both endothelium and androgen-dependent. This might justify the lack of efficacy of this drug in treatment of some form of organic erectile dysfunction...
  71. ncbi Structured interview on erectile dysfunction (SIEDY): a new, multidimensional instrument for quantification of pathogenetic issues on erectile dysfunction
    L Petrone
    Andrology Unit, University of Florence and International Institute of Sexuology, Florence, Italy
    Int J Impot Res 15:210-20. 2003
    ..Scale 1 (>3) had a sensitivity of 67.9% and a specificity of 67.6% for OC. SIEDY((c)) provides information on ED pathogenesis and might assist physicians in diagnostic and therapeutic choices...
  72. ncbi Des (1-3) IGF-I-stimulated growth of human stromal BPH cells is inhibited by a vitamin D3 analogue
    C Crescioli
    Endocrinology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Mol Cell Endocrinol 198:69-75. 2002
    ..Therefore, vitamin D(3) analogues might be considered for the medical treatment of BPH...
  73. ncbi The use of phosphodiesterase 5 inhibitors with concomitant medications
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Endocrinol Invest 31:799-808. 2008
    ..This is because sildenafil, vardenafil, and tadalafil are metabolized mainly via the CYP3A4 pathway. On the other hand, statins and testosterone seem to have synergic effects with PDE5i on sexual activity...
  74. doi Why can patients with erectile dysfunction be considered lucky? The association with testosterone deficiency and metabolic syndrome
    G Corona
    Department of Clinical Physiopathology, University of Florence, Italy
    Aging Male 11:193-9. 2008
    ....
  75. ncbi Inventories for male and female sexual dysfunctions
    G Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Impot Res 18:236-50. 2006
    ..In addition, SRQs could also be very useful in quantifying disease severity and treatment outcome. On the other hand, SIs help achieve a better patient-physician relationship and reduce the risk of misunderstandings...
  76. ncbi Varicocele and infertility
    G Forti
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Endocrinol Invest 26:564-9. 2003