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Genomes and Genes | Enrico MaggiSummaryAffiliation: University of Florence Country: Italy Publications
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Publications
Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytesFrancesco Annunziato
Department of Internal Medicine, University Florence, Italy
J Exp Med 196:379-87. 2002....
Thymic regulatory T cellsEnrico Maggi
Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
Autoimmun Rev 4:579-86. 2005..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens...- Tako-Tsubo-like syndrome during anaphylactic reactionAlessandra Vultaggio
Department of Biomedicine, Unit of Immunology and Cellular Therapy, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
Eur J Heart Fail 9:209-11. 2007..We describe the case of a young woman who experienced a profound reversible cardiomyopathy with typical features of Tako-Tsubo's syndrome during an anaphylactic reaction... 
Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interactionFrancesco Liotta
Excellence Center for Research, Transfer, and High Education, De Novo Therapy, University of Florence, Florence, Italy
J Allergy Clin Immunol 121:1000-5.e8. 2008..The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear...- Regeneration of glomerular podocytes by human renal progenitorsElisa Ronconi
Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
J Am Soc Nephrol 20:322-32. 2009.... - T-cell responses during allergen-specific immunotherapyEnrico Maggi
Section of Immunoallergology, Department of Internal Medicine, Center of Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
Curr Opin Allergy Clin Immunol 12:1-6. 2012.... - Acute infusion reactions induced by monoclonal antibody therapyEnrico Maggi
Center for Research, Transfer and High Education DENOthe, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
Expert Rev Clin Immunol 7:55-63. 2011..The anaphylaxis occurring during therapy with the anti-TNF-α mAb infliximab, largely used in immune-mediated diseases, has been taken as a paradigm... - T-cell responses induced by allergen-specific immunotherapyE Maggi
Department of Internal Medicine, Center of Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
Clin Exp Immunol 161:10-8. 2010.... - Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytesLorenzo Cosmi
Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
Blood 102:4107-14. 2003..These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells... - TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cellsVeronica Santarlasci
Centre of Excellence DENOthe, University of Florence, Florence, Italy
Eur J Immunol 39:207-15. 2009..These data suggest that TGF-beta is not critical for the differentiation of human Th17 cells, but indirectly favors their expansion because Th17 cells are poorly susceptible to its suppressive effects... - CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine productionPaola Romagnani
Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
J Allergy Clin Immunol 116:1372-9. 2005..This might represent an internal regulatory pathway of TH cell responses and might contribute to the modulation of chronic inflammatory reactions, including allergy... - Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signalingFrancesco Liotta
Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
Stem Cells 26:279-89. 2008.... - Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokinesLorenzo Cosmi
Department of Internal Medicine, University of Florence, Florence, Italy
Blood 103:3117-21. 2004.... - Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursorLorenzo Cosmi
Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
J Exp Med 205:1903-16. 2008..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor... - Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individualsLaura Maggi
Excellence Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
J Allergy Clin Immunol 120:429-36. 2007..CD4(+)CD25(+)Foxp3(+) T-regulatory (Treg) cells play a fundamental role in the control of autoimmunity. Whether human CD4(+)CD25(+)Foxp3(+) Treg cells that recognize foreign antigens also exist is less clear... - Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4Lorenzo Cosmi
Centre of Excellence DENOthe, University of Florence, Florence, Italy
J Allergy Clin Immunol 125:222-30.e1-4. 2010..IL-17A has been suggested to play a pathogenic role in bronchial asthma and other allergic disorders... - Vascular endothelial growth factor receptor-2 and low affinity VEGF binding sites on human glomerular endothelial cells: Biological effects and advanced glycosilation end products modulationLaura Pala
Department of Clinical Pathophysiology, Endocrinology Unit, Diabetes and Metabolic Diseases Section, University of Florence, viale Pieraccini 6 501354 Florence, Italy
Microvasc Res 70:179-88. 2005..The presence of AGEs, up-regulating the VEGFR-2 and decreasing HSPG sites might participate to the block of glomerular angiogenesis addressing the VEGF effects on glomerular permeability... - Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cellsBenedetta Mazzinghi
Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50121 Florence, Italy
J Exp Med 205:479-90. 2008.... - PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretionLaura Lasagni
Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Florence, Italy
Blood 109:4127-34. 2007..These results demonstrate that CXCL4 and CXCL4L1 exhibit a distinct subcellular localization and are secreted in a differentially regulated manner, suggesting distinct roles in inflammatory or homeostatic processes... - The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokinesAlessandra Vultaggio
Immunoallergology Unit, Careggi Hospital, 50134 Florence, Italy
J Immunol 186:4707-15. 2011..These findings suggest that such TLR7 agonist downregulating Th17 (as well as Th2) response has to be considered a valid candidate for novel vaccine formulations in allergy... - Phenotypic and functional features of human Th17 cellsFrancesco Annunziato
Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
J Exp Med 204:1849-61. 2007.... - T cells specific for Candida albicans antigens and producing type 2 cytokines in lesional mucosa of untreated HIV-infected patients with pseudomembranous oropharyngeal candidiasisAlessandra Vultaggio
Department of Internal Medicine, University of Firenze, Viale Morgagni 85, 50134 Firenze, Italy
Microbes Infect 10:166-74. 2008..These findings, showing a non-protective Th0/Th2 response to C. albicans antigen in the blood and lesional mucosa of HIV-infected patients with POPC, may explain the high susceptibility of candidiasis in these subjects... - Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7Alessandra Vultaggio
Center for Research, Transfer and High Education DENOthe, Department of Internal Medicine, University of Florence, Florence, Italy
J Immunol 182:880-9. 2009.... - CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORCLaura Maggi
Centre of Excellence DENOthe, University of Florence, Italy
Eur J Immunol 40:2174-81. 2010..Taken together, these data allow to conclude that T-cell subsets able to produce IL-17, as well as precursors of IL-17-producing T cells, exhibit surface expression of CD161, and that this feature is at least in part RORC2-dependent... - Regenerative potential of embryonic renal multipotent progenitors in acute renal failureElena Lazzeri
Excellence Center for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy
J Am Soc Nephrol 18:3128-38. 2007..The ability of these cells to repair renal damage, together with their apparent lack of tumorigenicity, suggests their potential in the treatment of renal failure... - Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN releaseLucia Filì
DENOthe Center for Research, Transfer and High Education, University of Florence, Via Morgagni 85, 50134 Florence, Italy
J Allergy Clin Immunol 118:511-7. 2006.... - The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammationFrancesco Annunziato
Center of Excellence for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Florence, Italy
Int Immunol 20:1361-8. 2008.... - The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cellsFrancesca Brugnolo
Department of Internal Medicine, Immunoallergology and Respiratory Disease Unit, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
J Allergy Clin Immunol 111:380-8. 2003..CONCLUSIONS: These results suggest that R-848, and probably other imidazoquinolines, might be used as adjuvants in view of novel allergen-specific immunotherapeutic regimens for the treatment of allergic disorders... - Distinctive features of classic and nonclassic (Th17 derived) human Th1 cellsLaura Maggi
Department of Internal Medicine and DENOTHE Center, University of Florence, Firenze, Italy
Eur J Immunol 42:3180-8. 2012.... - Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosisLorenzo Cosmi
Center for High Research DENOthe, University of Florence, Florence, Italy
Int Arch Allergy Immunol 143:1-9. 2007.... - Rarity of human T helper 17 cells is due to retinoic acid orphan receptor-dependent mechanisms that limit their expansionVeronica Santarlasci
Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
Immunity 36:201-14. 2012..Our findings suggest that the rarity of human Th17 cells in inflamed tissues results from RORC-dependent mechanisms limiting their expansion... - Human Th17 cells: are they different from murine Th17 cells?Francesco Annunziato
Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
Eur J Immunol 39:637-40. 2009..However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects... - An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4Laura Lasagni
Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
J Exp Med 197:1537-49. 2003.... - Properties and origin of human Th17 cellsSergio Romagnani
Department of Internal Medicine and Excellence Center DENOTHE, University of Florence, Firenze 50134, Italy
Mol Immunol 47:3-7. 2009..By contrast, TGF-beta does not play a direct role in human Th17 differentiation, but can only favour their expansion by inhibiting T-bet expression and the development of Th1 cells... - CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitorsPaola Romagnani
Center for Research, Transfer and High Education DENOthe, University of Florence, Italy
Circ Res 97:314-22. 2005.... - Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinomaFrancesco Liotta
Excellence Center for Research, Transfer, and High Education DENOthe, Department of Urology, University of Florence, Florence, Italy
BJU Int 107:1500-6. 2011..To verify in vitro the inhibitory activity of tumour isolated Tregs on the effector T cells and, finally, to assess the prognostic role of Treg frequency determination... - Drug-Specific Th2 Cells and IgE Antibodies in a Patient with Anaphylaxis to RituximabAlessandra Vultaggio
Immunoallergology Unit, Department of Biomedicine, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Int Arch Allergy Immunol 159:321-6. 2012..Our results show the presence of RTX-specific Th2-type cells and IgE antibodies, thus suggesting that type I hypersensitivity may be an additional mechanism to CRS in the development of RTX reactions... - Functional features of human CD25+ regulatory thymocytesFrancesco Liotta
Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy
Microbes Infect 7:1017-22. 2005..This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes... - Defining the human T helper 17 cell phenotypeFrancesco Annunziato
Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
Trends Immunol 33:505-12. 2012.... - Type 1 T helper cells specific for Candida albicans antigens in peripheral blood and vaginal mucosa of women with recurrent vaginal candidiasisMarie-Pierre Piccinni
Immunoallergology Section, Department of Internal Medicine, University of Florence, Florence, Italy
J Infect Dis 186:87-93. 2002..These findings provide direct evidence that RVC is characterized by a highly polarized local and circulating type 1 T helper cell-like response against C. albicans antigens... - AT1 and AT2 receptors in human glomerular endothelial cells at different passagesBarbara Cresci
Department of Clinical Pathophysiology, Endocrinology Unit, Diabetes and Metabolic Diseases Section, University of Florence, Viale Pieraccini 6-50134, Florence, Italy
Microvasc Res 66:22-9. 2003..AngII regulates the mitogenic effect through AT1a receptors (in later cell passages 4p-15p) involving the release of PDGF-BB, while AT2 (in early cell passage 2p) showed a predominant negative growth control... - CD4+CD161+ T Lymphocytes Infiltrate Crohn's Disease-Associated Perianal Fistulas and Are Reduced by Anti-TNF-α Local TherapyLaura Maggi
Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
Int Arch Allergy Immunol 161:81-6. 2013.... - Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneysCostanza Sagrinati
Interdepartmental Laboratory of Cellular and Molecular Nephrology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
J Am Soc Nephrol 17:2443-56. 2006.... - Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritisLorenzo Cosmi
University of Florence and Excellence Centre for Research, Transfer and Higher Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, Florence, Italy
Arthritis Rheum 63:2504-15. 2011..To investigate the phenotype and function of CD4+ T cells in synovial fluid (SF) from the affected joints of children with oligoarticular-onset juvenile idiopathic arthritis (JIA), and to establish a possible link with disease activity... - Type 17 T helper cells-origins, features and possible roles in rheumatic diseaseFrancesco Annunziato
Department of Internal Medicine, University of Florence, Firenze 50134, Italy
Nat Rev Rheumatol 5:325-31. 2009.... - Association between "sarcoidosis-like" disease and common variable immunodeficiency (CVI): a new CVI variant showing an activation of the immune systemAlessandra Vultaggio
Department of Biomedicine, Immunoallergology Unit, Policlinico di Careggi, AOUC Firenze, Italy
Sarcoidosis Vasc Diffuse Lung Dis 24:127-33. 2007..Particular interest has been recently addressed to the association between a Granulomatous Sarcoidosis-like Disease (GSa-LD) and Common Variable Immunodeficiency (CVI)... - Multiorgan infiltration by CD8+ T cells and 1p;16p translocation in a patient with hypogammaglobulinemia and a reduced number of B cellsAlessandra Vultaggio
Immunoallergology Unit, Department of Biomedicine, AOU Careggi, Florence, Italy
Int Arch Allergy Immunol 158:206-10. 2012..This suggests that a chromosomal abnormality plays a role in the clinical features of this phenotypic variant of CVID... - Role of low nuclear grading of renal carcinoma cells in the functional profile of tumor-infiltrating T cellsLuca Puccetti
Urology Unit, Department of Critical Medicine, Santa Maria Annunziata Hospital, University of Florence, Florence, Italy
Int J Cancer 98:674-81. 2002..These data address the association of the nuclear grading of neoplastic cells with different local tumor-specific T-cell responses in RCC... - Hypergravity speeds up the development of T-lymphocyte motilityMassimo Galimberti
LENS European Laboratory for Non Linear Spectroscopy, University of Florence, Sesto Fiorentino, FI, Italy
Eur Biophys J 35:393-400. 2006..We found that T cells, activated and then cultured in hypergravity, become motile earlier than cells cultured at normal gravity. These results suggest that hypergravity stimulates T cell migration... - Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malariaMaria G Torcia
Department of Clinical Physiopathology, University of Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
Proc Natl Acad Sci U S A 105:646-51. 2008..The results suggest that the higher resistance to malaria of the Fulani could derive from a functional deficit of T regulatory cells... - ["Sarcoidosis-like" granulomatous disease in patients with common variable hypogammaglobulinemia]Andrea Matucci
Sezione di Immunoallergologia e Malattie Respiratorie, Cattedra di Allergologia e Immunologia Clinica, Dipartimento di Medicina Interna, Universita degli Studi di Firenze
Ann Ital Med Int 17:108-16. 2002..In turn, the latter could be responsible for a more efficacious effector phase of the immune response. This may explain the reduced rate of infectious diseases and consequently of bronchiectasies observed in CVI patients... - Kimura's disease: case report of an Italian young male and response to oral cyclosporine A in an 8 years follow-upEnrico Beccastrini
Department of Biomedicine, Allergology and Clinical Immunology, University of Florence, V le Morgagni, 85, 50134 Florence, Italy
Clin Rheumatol 32:S55-7. 2013.... - Assessment of the risk of polyomavirus JC reactivation in patients with immune-mediated diseases during long-term treatment with infliximabSimone Giannecchini
Virology Unit, Department of Public Health, University of Florence, Florence, Italy
J Neurovirol 18:55-61. 2012..Although infliximab treatment in this study did not affect directly JCV reactivation, further investigation on host factor(s) regulated by it will be of warranty in the understanding the mechanism(s) that may affect viral persistence... - IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxidePaola Romagnani
Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
J Am Soc Nephrol 13:53-64. 2002..These data also indicate that the production of IP-10 and Mig by human mesangial cells can be downregulated by NO donors through cGMP-independent inhibition of NF-kappaB activation... - Th2-oriented profile of male offspring T cells present in women with systemic sclerosis and reactive with maternal major histocompatibility complex antigensCristina Scaletti
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, Florence 50134, Italy
Arthritis Rheum 46:445-50. 2002.... - Anti-cyclic citrullinated peptide antibodies are highly associated with severe bone lesions in rheumatoid arthritis anti-CCP and bone damage in RASusanna Maddali Bongi
Department of Medical and Surgical Care, Rheumatology Unit, University of Florence, Italy
Autoimmunity 37:495-501. 2004..25%). Data here reported confirm that the presence of anti-CCP are specific for diagnosis of RA, of recent onset also and they are potentially useful as prognostic index of bone involvement... - Immune regulation by mesenchymal stem cells derived from adult spleen and thymusMauro Krampera
Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
Stem Cells Dev 16:797-810. 2007..Our data suggest that not only do spleen and thymus have a stem cell reservoir to build up their stromal architecture, but also contain microenviromental immunoregulatory cells with the same properties of BM-MSCs... - Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cellsMauro Krampera
Department of Clinical and Experimental Medicine, University of Verona, Italy
Stem Cells 24:386-98. 2006..These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma...