Enrico Maggi

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. pmc Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    Francesco Annunziato
    Department of Internal Medicine, University Florence, Italy
    J Exp Med 196:379-87. 2002
  2. ncbi request reprint Thymic regulatory T cells
    Enrico Maggi
    Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
    Autoimmun Rev 4:579-86. 2005
  3. ncbi request reprint Tako-Tsubo-like syndrome during anaphylactic reaction
    Alessandra Vultaggio
    Department of Biomedicine, Unit of Immunology and Cellular Therapy, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Eur J Heart Fail 9:209-11. 2007
  4. doi request reprint Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction
    Francesco Liotta
    Excellence Center for Research, Transfer, and High Education, De Novo Therapy, University of Florence, Florence, Italy
    J Allergy Clin Immunol 121:1000-5.e8. 2008
  5. pmc Regeneration of glomerular podocytes by human renal progenitors
    Elisa Ronconi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
    J Am Soc Nephrol 20:322-32. 2009
  6. doi request reprint T-cell responses during allergen-specific immunotherapy
    Enrico Maggi
    Section of Immunoallergology, Department of Internal Medicine, Center of Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Curr Opin Allergy Clin Immunol 12:1-6. 2012
  7. pmc T-cell responses induced by allergen-specific immunotherapy
    E Maggi
    Department of Internal Medicine, Center of Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Clin Exp Immunol 161:10-8. 2010
  8. doi request reprint Acute infusion reactions induced by monoclonal antibody therapy
    Enrico Maggi
    Center for Research, Transfer and High Education DENOthe, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Expert Rev Clin Immunol 7:55-63. 2011
  9. ncbi request reprint Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    Lorenzo Cosmi
    Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
    Blood 102:4107-14. 2003
  10. doi request reprint TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells
    Veronica Santarlasci
    Centre of Excellence DENOthe, University of Florence, Florence, Italy
    Eur J Immunol 39:207-15. 2009

Collaborators

Detail Information

Publications63

  1. pmc Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    Francesco Annunziato
    Department of Internal Medicine, University Florence, Italy
    J Exp Med 196:379-87. 2002
    ....
  2. ncbi request reprint Thymic regulatory T cells
    Enrico Maggi
    Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
    Autoimmun Rev 4:579-86. 2005
    ..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens...
  3. ncbi request reprint Tako-Tsubo-like syndrome during anaphylactic reaction
    Alessandra Vultaggio
    Department of Biomedicine, Unit of Immunology and Cellular Therapy, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Eur J Heart Fail 9:209-11. 2007
    ..We describe the case of a young woman who experienced a profound reversible cardiomyopathy with typical features of Tako-Tsubo's syndrome during an anaphylactic reaction...
  4. doi request reprint Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction
    Francesco Liotta
    Excellence Center for Research, Transfer, and High Education, De Novo Therapy, University of Florence, Florence, Italy
    J Allergy Clin Immunol 121:1000-5.e8. 2008
    ..The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear...
  5. pmc Regeneration of glomerular podocytes by human renal progenitors
    Elisa Ronconi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
    J Am Soc Nephrol 20:322-32. 2009
    ....
  6. doi request reprint T-cell responses during allergen-specific immunotherapy
    Enrico Maggi
    Section of Immunoallergology, Department of Internal Medicine, Center of Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Curr Opin Allergy Clin Immunol 12:1-6. 2012
    ....
  7. pmc T-cell responses induced by allergen-specific immunotherapy
    E Maggi
    Department of Internal Medicine, Center of Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Clin Exp Immunol 161:10-8. 2010
    ....
  8. doi request reprint Acute infusion reactions induced by monoclonal antibody therapy
    Enrico Maggi
    Center for Research, Transfer and High Education DENOthe, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Expert Rev Clin Immunol 7:55-63. 2011
    ..The anaphylaxis occurring during therapy with the anti-TNF-α mAb infliximab, largely used in immune-mediated diseases, has been taken as a paradigm...
  9. ncbi request reprint Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    Lorenzo Cosmi
    Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
    Blood 102:4107-14. 2003
    ..These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells...
  10. doi request reprint TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells
    Veronica Santarlasci
    Centre of Excellence DENOthe, University of Florence, Florence, Italy
    Eur J Immunol 39:207-15. 2009
    ..These data suggest that TGF-beta is not critical for the differentiation of human Th17 cells, but indirectly favors their expansion because Th17 cells are poorly susceptible to its suppressive effects...
  11. ncbi request reprint Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release
    Lucia Filì
    DENOthe Center for Research, Transfer and High Education, University of Florence, Via Morgagni 85, 50134 Florence, Italy
    J Allergy Clin Immunol 118:511-7. 2006
    ....
  12. ncbi request reprint Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines
    Lorenzo Cosmi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Blood 103:3117-21. 2004
    ....
  13. ncbi request reprint CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production
    Paola Romagnani
    Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
    J Allergy Clin Immunol 116:1372-9. 2005
    ..Two variants of the CXCR3 receptor exist, one (CXCR3-A) reactive with CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both variants are contemporarily expressed by human T cells...
  14. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
    ..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor...
  15. ncbi request reprint Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling
    Francesco Liotta
    Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
    Stem Cells 26:279-89. 2008
    ....
  16. doi request reprint Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4
    Lorenzo Cosmi
    Centre of Excellence DENOthe, University of Florence, Florence, Italy
    J Allergy Clin Immunol 125:222-30.e1-4. 2010
    ..IL-17A has been suggested to play a pathogenic role in bronchial asthma and other allergic disorders...
  17. ncbi request reprint Vascular endothelial growth factor receptor-2 and low affinity VEGF binding sites on human glomerular endothelial cells: Biological effects and advanced glycosilation end products modulation
    Laura Pala
    Department of Clinical Pathophysiology, Endocrinology Unit, Diabetes and Metabolic Diseases Section, University of Florence, viale Pieraccini 6 501354 Florence, Italy
    Microvasc Res 70:179-88. 2005
    ..The presence of AGEs, up-regulating the VEGFR-2 and decreasing HSPG sites might participate to the block of glomerular angiogenesis addressing the VEGF effects on glomerular permeability...
  18. ncbi request reprint Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individuals
    Laura Maggi
    Excellence Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
    J Allergy Clin Immunol 120:429-36. 2007
    ..CD4(+)CD25(+)Foxp3(+) T-regulatory (Treg) cells play a fundamental role in the control of autoimmunity. Whether human CD4(+)CD25(+)Foxp3(+) Treg cells that recognize foreign antigens also exist is less clear...
  19. pmc Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells
    Benedetta Mazzinghi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50121 Florence, Italy
    J Exp Med 205:479-90. 2008
    ....
  20. ncbi request reprint PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion
    Laura Lasagni
    Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Florence, Italy
    Blood 109:4127-34. 2007
    ..These results demonstrate that CXCL4 and CXCL4L1 exhibit a distinct subcellular localization and are secreted in a differentially regulated manner, suggesting distinct roles in inflammatory or homeostatic processes...
  21. doi request reprint The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines
    Alessandra Vultaggio
    Immunoallergology Unit, Careggi Hospital, 50134 Florence, Italy
    J Immunol 186:4707-15. 2011
    ..These findings suggest that such TLR7 agonist downregulating Th17 (as well as Th2) response has to be considered a valid candidate for novel vaccine formulations in allergy...
  22. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
    ....
  23. doi request reprint T cells specific for Candida albicans antigens and producing type 2 cytokines in lesional mucosa of untreated HIV-infected patients with pseudomembranous oropharyngeal candidiasis
    Alessandra Vultaggio
    Department of Internal Medicine, University of Firenze, Viale Morgagni 85, 50134 Firenze, Italy
    Microbes Infect 10:166-74. 2008
    ..These findings, showing a non-protective Th0/Th2 response to C. albicans antigen in the blood and lesional mucosa of HIV-infected patients with POPC, may explain the high susceptibility of candidiasis in these subjects...
  24. doi request reprint CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC
    Laura Maggi
    Centre of Excellence DENOthe, University of Florence, Italy
    Eur J Immunol 40:2174-81. 2010
    ..Taken together, these data allow to conclude that T-cell subsets able to produce IL-17, as well as precursors of IL-17-producing T cells, exhibit surface expression of CD161, and that this feature is at least in part RORC2-dependent...
  25. ncbi request reprint Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7
    Alessandra Vultaggio
    Center for Research, Transfer and High Education DENOthe, Department of Internal Medicine, University of Florence, Florence, Italy
    J Immunol 182:880-9. 2009
    ....
  26. ncbi request reprint Regenerative potential of embryonic renal multipotent progenitors in acute renal failure
    Elena Lazzeri
    Excellence Center for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy
    J Am Soc Nephrol 18:3128-38. 2007
    ..The ability of these cells to repair renal damage, together with their apparent lack of tumorigenicity, suggests their potential in the treatment of renal failure...
  27. ncbi request reprint The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells
    Francesca Brugnolo
    Department of Internal Medicine, Immunoallergology and Respiratory Disease Unit, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
    J Allergy Clin Immunol 111:380-8. 2003
    ..In experimental models, imidazoquinolines exhibit several immunomodulatory activities via Toll-like receptor signaling on cells of the innate immunity...
  28. doi request reprint The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation
    Francesco Annunziato
    Center of Excellence for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Florence, Italy
    Int Immunol 20:1361-8. 2008
    ....
  29. ncbi request reprint IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells
    Veronica Santarlasci
    Department of Experimental and Clinical Medicine and DENOTHE Center, University of Florence, Florence, Italy
    Eur J Immunol 44:654-61. 2014
    ....
  30. ncbi request reprint Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosis
    Lorenzo Cosmi
    Center for High Research DENOthe, University of Florence, Florence, Italy
    Int Arch Allergy Immunol 143:1-9. 2007
    ....
  31. doi request reprint Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells
    Laura Maggi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Firenze, Italy
    Eur J Immunol 42:3180-8. 2012
    ....
  32. ncbi request reprint Brief report: etanercept inhibits the tumor necrosis factor α-driven shift of Th17 lymphocytes toward a nonclassic Th1 phenotype in juvenile idiopathic arthritis
    Laura Maggi
    University of Florence, Florence, Italy
    Arthritis Rheumatol 66:1372-7. 2014
    ..To evaluate the effects of etanercept on the phenotype of CD4+ T helper lymphocytes from patients with juvenile idiopathic arthritis (JIA)...
  33. doi request reprint A novel allergen-adjuvant conjugate suitable for specific immunotherapy of respiratory allergy
    Lucia Filì
    Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    J Allergy Clin Immunol 132:84-92. 2013
    ..Several approaches to find a better adjuvant, focus immunomodulation, and reduce allergenicity are under investigation to improve the efficacy and safety of specific immunotherapy...
  34. doi request reprint Rarity of human T helper 17 cells is due to retinoic acid orphan receptor-dependent mechanisms that limit their expansion
    Veronica Santarlasci
    Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
    Immunity 36:201-14. 2012
    ..Our findings suggest that the rarity of human Th17 cells in inflamed tissues results from RORC-dependent mechanisms limiting their expansion...
  35. pmc An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4
    Laura Lasagni
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Exp Med 197:1537-49. 2003
    ....
  36. doi request reprint Human Th17 cells: are they different from murine Th17 cells?
    Francesco Annunziato
    Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
    Eur J Immunol 39:637-40. 2009
    ..However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects...
  37. doi request reprint Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma
    Francesco Liotta
    Excellence Center for Research, Transfer, and High Education DENOthe, Department of Urology, University of Florence, Florence, Italy
    BJU Int 107:1500-6. 2011
    ..To verify in vitro the inhibitory activity of tumour isolated Tregs on the effector T cells and, finally, to assess the prognostic role of Treg frequency determination...
  38. ncbi request reprint CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors
    Paola Romagnani
    Center for Research, Transfer and High Education DENOthe, University of Florence, Italy
    Circ Res 97:314-22. 2005
    ....
  39. doi request reprint Properties and origin of human Th17 cells
    Sergio Romagnani
    Department of Internal Medicine and Excellence Center DENOTHE, University of Florence, Firenze 50134, Italy
    Mol Immunol 47:3-7. 2009
    ..By contrast, TGF-beta does not play a direct role in human Th17 differentiation, but can only favour their expansion by inhibiting T-bet expression and the development of Th1 cells...
  40. doi request reprint CD4+CD161+ T lymphocytes infiltrate Crohn's disease-associated perianal fistulas and are reduced by anti-TNF-α local therapy
    Laura Maggi
    Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Int Arch Allergy Immunol 161:81-6. 2013
    ..In this work we assessed the presence and the functional features of CD161 T helper lymphocytes infiltrating CD-associated perianal fistulas, both before and after inoculation of anti-TNF-α mAbs along the fistula...
  41. doi request reprint Main features of human T helper 17 cells
    Francesco Annunziato
    Laboratory of Immunology, Allergology and Cellular Therapies, Department of Internal Medicine and DENOTHE Center, University of Florence, Italy
    Ann N Y Acad Sci 1284:66-70. 2013
    ..The possible role of Th17 cells in human tumors is still unclear and even controversial...
  42. doi request reprint Drug-specific Th2 cells and IgE antibodies in a patient with anaphylaxis to rituximab
    Alessandra Vultaggio
    Immunoallergology Unit, Department of Biomedicine, Azienda Ospedaliero Universitaria Careggi, Florence, Italy vultaggioa aou careggi toscana it
    Int Arch Allergy Immunol 159:321-6. 2012
    ..Our results show the presence of RTX-specific Th2-type cells and IgE antibodies, thus suggesting that type I hypersensitivity may be an additional mechanism to CRS in the development of RTX reactions...
  43. ncbi request reprint Functional features of human CD25+ regulatory thymocytes
    Francesco Liotta
    Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy
    Microbes Infect 7:1017-22. 2005
    ..This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes...
  44. ncbi request reprint Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys
    Costanza Sagrinati
    Interdepartmental Laboratory of Cellular and Molecular Nephrology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    J Am Soc Nephrol 17:2443-56. 2006
    ....
  45. doi request reprint Defining the human T helper 17 cell phenotype
    Francesco Annunziato
    Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
    Trends Immunol 33:505-12. 2012
    ....
  46. ncbi request reprint Type 1 T helper cells specific for Candida albicans antigens in peripheral blood and vaginal mucosa of women with recurrent vaginal candidiasis
    Marie Pierre Piccinni
    Immunoallergology Section, Department of Internal Medicine, University of Florence, Florence, Italy
    J Infect Dis 186:87-93. 2002
    ..These findings provide direct evidence that RVC is characterized by a highly polarized local and circulating type 1 T helper cell-like response against C. albicans antigens...
  47. ncbi request reprint AT1 and AT2 receptors in human glomerular endothelial cells at different passages
    Barbara Cresci
    Department of Clinical Pathophysiology, Endocrinology Unit, Diabetes and Metabolic Diseases Section, University of Florence, Viale Pieraccini 6 50134, Florence, Italy
    Microvasc Res 66:22-9. 2003
    ..AngII regulates the mitogenic effect through AT1a receptors (in later cell passages 4p-15p) involving the release of PDGF-BB, while AT2 (in early cell passage 2p) showed a predominant negative growth control...
  48. ncbi request reprint Association between "sarcoidosis-like" disease and common variable immunodeficiency (CVI): a new CVI variant showing an activation of the immune system
    Alessandra Vultaggio
    Department of Biomedicine, Immunoallergology Unit, Policlinico di Careggi, AOUC Firenze, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 24:127-33. 2007
    ..Particular interest has been recently addressed to the association between a Granulomatous Sarcoidosis-like Disease (GSa-LD) and Common Variable Immunodeficiency (CVI)...
  49. doi request reprint Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis
    Lorenzo Cosmi
    University of Florence and Excellence Centre for Research, Transfer and Higher Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, Florence, Italy
    Arthritis Rheum 63:2504-15. 2011
    ..To investigate the phenotype and function of CD4+ T cells in synovial fluid (SF) from the affected joints of children with oligoarticular-onset juvenile idiopathic arthritis (JIA), and to establish a possible link with disease activity...
  50. doi request reprint Type 17 T helper cells-origins, features and possible roles in rheumatic disease
    Francesco Annunziato
    Department of Internal Medicine, University of Florence, Firenze 50134, Italy
    Nat Rev Rheumatol 5:325-31. 2009
    ....
  51. ncbi request reprint Hypergravity speeds up the development of T-lymphocyte motility
    Massimo Galimberti
    LENS European Laboratory for Non Linear Spectroscopy, University of Florence, Sesto Fiorentino, FI, Italy
    Eur Biophys J 35:393-400. 2006
    ..We found that T cells, activated and then cultured in hypergravity, become motile earlier than cells cultured at normal gravity. These results suggest that hypergravity stimulates T cell migration...
  52. doi request reprint HLA-G5 induces IL-4 secretion critical for successful pregnancy through differential expression of ILT2 receptor on decidual CD4⁺ T cells and macrophages
    Letizia Lombardelli
    Department of Experimental and Clinical Medicine, Center of Excellence for the study at molecular and clinical level of chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, 50134 Florence, Italy
    J Immunol 191:3651-62. 2013
    ..Therefore, HLA-G5 could be responsible, at least in part, via its interaction with ILT2, for decidual T cell IL-4 production, known to be crucial for successful pregnancy. ..
  53. doi request reprint Multiorgan infiltration by CD8+ T cells and 1p;16p translocation in a patient with hypogammaglobulinemia and a reduced number of B cells
    Alessandra Vultaggio
    Immunoallergology Unit, Department of Biomedicine, AOU Careggi, Florence, Italy
    Int Arch Allergy Immunol 158:206-10. 2012
    ..This suggests that a chromosomal abnormality plays a role in the clinical features of this phenotypic variant of CVID...
  54. ncbi request reprint Role of low nuclear grading of renal carcinoma cells in the functional profile of tumor-infiltrating T cells
    Luca Puccetti
    Urology Unit, Department of Critical Medicine, Santa Maria Annunziata Hospital, University of Florence, Florence, Italy
    Int J Cancer 98:674-81. 2002
    ..These data address the association of the nuclear grading of neoplastic cells with different local tumor-specific T-cell responses in RCC...
  55. doi request reprint Kimura's disease: case report of an Italian young male and response to oral cyclosporine A in an 8 years follow-up
    Enrico Beccastrini
    Department of Biomedicine, Allergology and Clinical Immunology, University of Florence, V le Morgagni, 85, 50134 Florence, Italy
    Clin Rheumatol 32:S55-7. 2013
    ....
  56. pmc Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria
    Maria G Torcia
    Department of Clinical Physiopathology, University of Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
    Proc Natl Acad Sci U S A 105:646-51. 2008
    ..The results suggest that the higher resistance to malaria of the Fulani could derive from a functional deficit of T regulatory cells...
  57. ncbi request reprint ["Sarcoidosis-like" granulomatous disease in patients with common variable hypogammaglobulinemia]
    Andrea Matucci
    Sezione di Immunoallergologia e Malattie Respiratorie, Cattedra di Allergologia e Immunologia Clinica, Dipartimento di Medicina Interna, Universita degli Studi di Firenze
    Ann Ital Med Int 17:108-16. 2002
    ..In turn, the latter could be responsible for a more efficacious effector phase of the immune response. This may explain the reduced rate of infectious diseases and consequently of bronchiectasies observed in CVI patients...
  58. doi request reprint Assessment of the risk of polyomavirus JC reactivation in patients with immune-mediated diseases during long-term treatment with infliximab
    Simone Giannecchini
    Virology Unit, Department of Public Health, University of Florence, Florence, Italy
    J Neurovirol 18:55-61. 2012
    ..Although infliximab treatment in this study did not affect directly JCV reactivation, further investigation on host factor(s) regulated by it will be of warranty in the understanding the mechanism(s) that may affect viral persistence...
  59. ncbi request reprint IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxide
    Paola Romagnani
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
    J Am Soc Nephrol 13:53-64. 2002
    ..These data also indicate that the production of IP-10 and Mig by human mesangial cells can be downregulated by NO donors through cGMP-independent inhibition of NF-kappaB activation...
  60. ncbi request reprint Th2-oriented profile of male offspring T cells present in women with systemic sclerosis and reactive with maternal major histocompatibility complex antigens
    Cristina Scaletti
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Arthritis Rheum 46:445-50. 2002
    ..To characterize the cytokine production profile of male-offspring T cells reactive against maternal major histocompatibility complex (MHC) antigens present in the peripheral blood and/or skin from women with systemic sclerosis (SSc)...
  61. ncbi request reprint Anti-cyclic citrullinated peptide antibodies are highly associated with severe bone lesions in rheumatoid arthritis anti-CCP and bone damage in RA
    Susanna Maddali Bongi
    Department of Medical and Surgical Care, Rheumatology Unit, University of Florence, Italy
    Autoimmunity 37:495-501. 2004
    ..25%). Data here reported confirm that the presence of anti-CCP are specific for diagnosis of RA, of recent onset also and they are potentially useful as prognostic index of bone involvement...
  62. ncbi request reprint Immune regulation by mesenchymal stem cells derived from adult spleen and thymus
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Stem Cells Dev 16:797-810. 2007
    ..Our data suggest that not only do spleen and thymus have a stem cell reservoir to build up their stromal architecture, but also contain microenviromental immunoregulatory cells with the same properties of BM-MSCs...
  63. ncbi request reprint Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    Stem Cells 24:386-98. 2006
    ..These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma...