ADRIANA CATERINA MAGGI

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint In vivo dynamics of estrogen receptor activity: the ERE-Luc model
    Adriana Maggi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy Electronic address
    J Steroid Biochem Mol Biol 139:262-9. 2014
  2. pmc A lack of ovarian function increases neuroinflammation in aged mice
    Valeria Benedusi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Endocrinology 153:2777-88. 2012
  3. ncbi request reprint Molecular imaging
    A Maggi
    Centre of Excellence of Neurodegenerative Diseases, Institute of Pharmacological Sciences, University of Milan, Milan, Italy
    Q J Nucl Med Mol Imaging 51:95. 2007
  4. ncbi request reprint Techniques: reporter mice - a new way to look at drug action
    Adriana Maggi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Trends Pharmacol Sci 25:337-42. 2004
  5. ncbi request reprint Estrogens in the nervous system: mechanisms and nonreproductive functions
    Adriana Maggi
    University of Milan, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, Via Balzaretti 920129 Milan, Italy
    Annu Rev Physiol 66:291-313. 2004
  6. ncbi request reprint Diabetes undermines estrogen control of inducible nitric oxide synthase function in rat aortic smooth muscle cells through overexpression of estrogen receptor-beta
    Adriana Maggi
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Disease, University of Milan, Italy
    Circulation 108:211-7. 2003
  7. pmc Molecular imaging provides novel insights on estrogen receptor activity in mouse brain
    Alessia Stell
    Center for Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Mol Imaging 7:283-92. 2008
  8. pmc Liganded and unliganded activation of estrogen receptor and hormone replacement therapies
    Adriana Maggi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Biochim Biophys Acta 1812:1054-60. 2011
  9. ncbi request reprint Identification of estrogen target genes in human neural cells
    A Maggi
    Center Milan Molecular Pharmacology Laboratory, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    J Steroid Biochem Mol Biol 74:319-25. 2000
  10. ncbi request reprint Multimodality imaging: novel pharmacological applications of reporter systems
    A Stell
    Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Q J Nucl Med Mol Imaging 51:127-38. 2007

Research Grants

Collaborators

Detail Information

Publications20

  1. doi request reprint In vivo dynamics of estrogen receptor activity: the ERE-Luc model
    Adriana Maggi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy Electronic address
    J Steroid Biochem Mol Biol 139:262-9. 2014
    ..This article is part of a Special Issue entitled 'Phytoestrogens'. ..
  2. pmc A lack of ovarian function increases neuroinflammation in aged mice
    Valeria Benedusi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Endocrinology 153:2777-88. 2012
    ..Taken together, the present results show that aging is associated with decreased ER activity, despite continuous ER synthesis, and that age-dependent neuroinflammation is strongly influenced by hormone deprivation...
  3. ncbi request reprint Molecular imaging
    A Maggi
    Centre of Excellence of Neurodegenerative Diseases, Institute of Pharmacological Sciences, University of Milan, Milan, Italy
    Q J Nucl Med Mol Imaging 51:95. 2007
  4. ncbi request reprint Techniques: reporter mice - a new way to look at drug action
    Adriana Maggi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Trends Pharmacol Sci 25:337-42. 2004
    ....
  5. ncbi request reprint Estrogens in the nervous system: mechanisms and nonreproductive functions
    Adriana Maggi
    University of Milan, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, Via Balzaretti 920129 Milan, Italy
    Annu Rev Physiol 66:291-313. 2004
    ..These findings are of major interest because estradiol might become an important therapeutic agent to maintain neural functions during aging and in selected neural diseases...
  6. ncbi request reprint Diabetes undermines estrogen control of inducible nitric oxide synthase function in rat aortic smooth muscle cells through overexpression of estrogen receptor-beta
    Adriana Maggi
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Disease, University of Milan, Italy
    Circulation 108:211-7. 2003
    ..In this study, we investigated the effect of 17beta-estradiol on iNOS function in aortic SMC from streptozotocin-diabetic rats...
  7. pmc Molecular imaging provides novel insights on estrogen receptor activity in mouse brain
    Alessia Stell
    Center for Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Mol Imaging 7:283-92. 2008
    ..Because of its reproducibility and sensitivity, this novel bioluminescence application stands as a candidate as an innovative methodology for the study and development of drugs targeting brain estrogen receptors...
  8. pmc Liganded and unliganded activation of estrogen receptor and hormone replacement therapies
    Adriana Maggi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Biochim Biophys Acta 1812:1054-60. 2011
    ..This article is part of a Special Issue entitled: Translating Nuclear receptors from health to disease...
  9. ncbi request reprint Identification of estrogen target genes in human neural cells
    A Maggi
    Center Milan Molecular Pharmacology Laboratory, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    J Steroid Biochem Mol Biol 74:319-25. 2000
    ....
  10. ncbi request reprint Multimodality imaging: novel pharmacological applications of reporter systems
    A Stell
    Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Q J Nucl Med Mol Imaging 51:127-38. 2007
    ....
  11. ncbi request reprint Decrease of the number of opioid receptors and of the responsiveness to morphineduring neuronal differentiation induced by 17beta-estradiol in estrogen receptor-transfected neuroblastoma cells (SK-ER3)
    R Maggi
    Department of Endocrinology, Institute of Pharmacological Sciences, University of Milan, Italy
    Neuroendocrinology 69:54-62. 1999
    ..Binding experiments performed using selective ligands suggest that the micro subclass of opioid receptors is down-regulated by estradiol in SK-ER3 cells...
  12. ncbi request reprint The dynamics of estrogen receptor activity
    P Ciana
    Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Maturitas 54:315-20. 2006
    ..This discovery may pave the way to a rational basis for the development of novel, more selective and effective treatments for menopause...
  13. ncbi request reprint Molecular imaging: a new way to study molecular processes in vivo
    L Ottobrini
    Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Mol Cell Endocrinol 246:69-75. 2006
    ....
  14. ncbi request reprint Activation of brain estrogen receptors in mice lactating from mothers exposed to DDT
    P Mussi
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Brain Res Bull 65:241-7. 2005
    ..Taken together these data lead to hypothesize that the delayed DDT time course on estrogen receptor activation in vivo might be due to a necessary step of metabolism of the compound...
  15. ncbi request reprint Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2
    S Belcredito
    Center of Excellence for Neurodegenerative Disorders and Department of Pharmacological Sciences University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Brain Res Brain Res Rev 37:335-42. 2001
    ....
  16. ncbi request reprint Nucleotide sequence of estrogen receptor cDNA from Sprague-Dawley rat
    E Spreafico
    Milano Molecular Pharmacology Laboratory, University of Milan, Italy
    Eur J Pharmacol 227:353-6. 1992
    ..Since tryptophan was found at the same position in chicken, human and mouse estrogen receptors, it is proposed that the Wistar rat could represent an interesting natural mutant for estrogen receptor studies...
  17. ncbi request reprint Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia
    E Vegeto
    Milano Molecular Pharmacology Lab, and Institute of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 21:1809-18. 2001
    ..Our study proposes a novel explanation for the protective effects of estrogen in neurodegenerative and inflammatory diseases and provides new molecular and cellular targets for the screening of ER ligands acting in the CNS...
  18. pmc The conundrum of estrogen receptor oscillatory activity in the search for an appropriate hormone replacement therapy
    Sara Della Torre
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Endocrinology 152:2256-65. 2011
    ..Thus, this mechanism needs to be taken in due consideration to develop novel, more efficacious, and safer hormone replacement therapies...
  19. ncbi request reprint Estrogen and inflammation: hormone generous action spreads to the brain
    E Vegeto
    Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Mol Psychiatry 7:236-8. 2002
  20. pmc An innovative method to classify SERMs based on the dynamics of estrogen receptor transcriptional activity in living animals
    Gianpaolo Rando
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Mol Endocrinol 24:735-44. 2010
    ..The application of this methodology is expected to simplify the identification of families of molecules functionally correlated and to speed up the process of drug discovery...

Research Grants5

  1. Menopause: Decreased Response to Increasing Inflammation
    Adriana Maggi; Fiscal Year: 2007
    ....
  2. Menopause: Decreased Response to Increasing Inflammation
    ADRIANA CATERINA MAGGI; Fiscal Year: 2010
    ....