M Maccarrone

Summary

Affiliation: University of Teramo
Country: Italy

Publications

  1. ncbi request reprint Cholesterol-dependent modulation of the toxicity of HIV-1 coat protein gp120 in human neuroblastoma cells
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 82:1444-52. 2002
  2. ncbi request reprint Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Pizza A Moro 45, 64100 Teramo, Italy
    J Cell Sci 118:4393-404. 2005
  3. pmc Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease
    Claudio D'Addario
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    PLoS ONE 7:e39186. 2012
  4. pmc Differences in the endocannabinoid system of sperm from fertile and infertile men
    Sheena E M Lewis
    School of Medicine, Centre for Public Health, Queen s University Belfast, Institute of Clinical Science, Belfast, United Kingdom
    PLoS ONE 7:e47704. 2012
  5. doi request reprint 5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: data from the ROALD experiment
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    FASEB J 26:1791-8. 2012
  6. pmc Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells
    Monica Bari
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Neuropharmacology 54:45-50. 2008
  7. pmc Good news for CB1 receptors: endogenous agonists are in the right place
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Br J Pharmacol 153:179-81. 2008
  8. ncbi request reprint Central and peripheral interactions between endocannabinoids and steroids, and implications for drug dependence
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Life Sci 77:1559-68. 2005
  9. doi request reprint Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
    Mauro Maccarrone
    Dipartimento di Scienze Biomediche, Università degli Studi di Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
    Nat Neurosci 11:152-9. 2008
  10. doi request reprint Endocannabinoids: friends and foes of reproduction
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, Teramo 64100, Italy
    Prog Lipid Res 48:344-54. 2009

Detail Information

Publications127 found, 100 shown here

  1. ncbi request reprint Cholesterol-dependent modulation of the toxicity of HIV-1 coat protein gp120 in human neuroblastoma cells
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 82:1444-52. 2002
    ..Taken together, these results suggest that membrane fluidity may control the neurotoxic effects of HIV-1 glycoprotein gp120...
  2. ncbi request reprint Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Pizza A Moro 45, 64100 Teramo, Italy
    J Cell Sci 118:4393-404. 2005
    ..These observations open new perspectives on the understanding and treatment of male fertility problems...
  3. pmc Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease
    Claudio D'Addario
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    PLoS ONE 7:e39186. 2012
    ..In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes...
  4. pmc Differences in the endocannabinoid system of sperm from fertile and infertile men
    Sheena E M Lewis
    School of Medicine, Centre for Public Health, Queen s University Belfast, Institute of Clinical Science, Belfast, United Kingdom
    PLoS ONE 7:e47704. 2012
    ..These alterations might also point to new biomarkers to determine male reproductive defects, and identify distinct ECS elements as novel targets for therapeutic exploitation of ECS-oriented drugs to treat male fertility problems...
  5. doi request reprint 5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: data from the ROALD experiment
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    FASEB J 26:1791-8. 2012
    ..Our findings provide a molecular background for the immune dysfunction observed in astronauts during space missions, and reveal potential new markers to monitor health status of ISS crew members...
  6. pmc Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells
    Monica Bari
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Neuropharmacology 54:45-50. 2008
    ..These findings may be relevant for the manifold CB1R-dependent activities of endocannabinoids, like the regulation of apoptosis and of neurodegenerative diseases...
  7. pmc Good news for CB1 receptors: endogenous agonists are in the right place
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Br J Pharmacol 153:179-81. 2008
    ..It also raises an important question about the structural determinants responsible for a different localization of two apparently similar endocannabinoids within lipid bilayers...
  8. ncbi request reprint Central and peripheral interactions between endocannabinoids and steroids, and implications for drug dependence
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Life Sci 77:1559-68. 2005
    ..Finally, I present the hypothesis that retrograde endocannabinoid signaling, by reducing striatal glutamate release, may be part of the molecular events responsible for the influence of steroids on drug abuse...
  9. doi request reprint Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
    Mauro Maccarrone
    Dipartimento di Scienze Biomediche, Università degli Studi di Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
    Nat Neurosci 11:152-9. 2008
    ..Consistently, the interaction between AEA and 2-AG was lost after pharmacological and genetic inactivation of TRPV1 channels...
  10. doi request reprint Endocannabinoids: friends and foes of reproduction
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, Teramo 64100, Italy
    Prog Lipid Res 48:344-54. 2009
    ....
  11. pmc Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo 64100, Italy
    Br J Pharmacol 163:1379-90. 2011
    ..The results of these investigations might be exploited also for the development of novel therapeutics able to combat disorders associated with abnormal activity of CB(1)...
  12. ncbi request reprint Human platelets express authentic CB₁ and CB₂ receptors
    M V Catani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Curr Neurovasc Res 7:311-8. 2010
    ..It seems remarkable that some of these substances have been already used in humans to treat disease states...
  13. ncbi request reprint The endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases
    Diego Centonze
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Curr Pharm Des 14:2370-42. 2008
    ....
  14. doi request reprint The endocannabinoid system and its relevance for nutrition
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Annu Rev Nutr 30:423-40. 2010
    ..The central and peripheral pathways that underlie these effects are discussed, as well as the possible exploitation of ECS components as novel drug targets for therapeutic intervention in eating disorders...
  15. doi request reprint Intracellular trafficking of anandamide: new concepts for signaling
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
    Trends Biochem Sci 35:601-8. 2010
    ....
  16. pmc Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA
    Mauro Maccarrone
    Dipartimento di Scienze Biomediche, Università degli Studi di Teramo, Teramo, Italy
    Neuropsychopharmacology 35:1500-9. 2010
    ....
  17. ncbi request reprint N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity
    M Taccone-Gallucci
    Section of Nephrology, Department of Biopathology and Imaging Techniques, Tor Vergata University, Rome, Italy
    Kidney Int 69:1450-4. 2006
    ..Upregulation of 5-Lox may also be related to the increased mitochondrial damage and apoptosis of PBMCs observed in ESRD patients compared to non-uremic controls. Omega-3 may thus protect PBMCs of ESRD patients against oxidative stress...
  18. pmc CB2 receptors in reproduction
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Br J Pharmacol 153:189-98. 2008
    ..It is hoped that CB2-dependent endocannabinoid signalling might become a useful target for correcting infertility, in both men and women...
  19. ncbi request reprint The photoreceptor protector zeaxanthin induces cell death in neuroblastoma cells
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Anticancer Res 25:3871-6. 2005
    ..Since zeaxanthin can inhibit lipid peroxidation and beta-carotene inhibits lipoxygenase (LOX) activity, it was of concern that zeaxanthin might inhibit apoptosis in these cancer cells...
  20. ncbi request reprint The endocannabinoid pathway in Huntington's disease: a comparison with other neurodegenerative diseases
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Prog Neurobiol 81:349-79. 2007
    ..Also the plastic changes of endocannabinoids in multiple sclerosis will be reviewed, as a paradigm of their impact in neuroinflammatory disorders...
  21. ncbi request reprint Redox regulation by ischemia/reperfusion
    M Maccarrone
    Department of Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy
    Cell Death Differ 13:2002-3. 2006
  22. ncbi request reprint Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Thromb Haemost 95:117-27. 2006
    ....
  23. ncbi request reprint Endocannabinoids and reproductive endocrinology
    Mauro Maccarrone
    University of Teramo, Department of Biomedical Sciences, Piazza A Moro 45, 64100 Teramo, Italy
    Curr Opin Investig Drugs 10:305-10. 2009
    ..The data for endocannabinoids suggest that these molecules can be proposed as novel lipid hormones (lipokines) that are critically involved in reproductive events...
  24. doi request reprint Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum
    Mauro Maccarrone
    Dipartimento di Scienze Biomediche, Università degli Studi di Teramo, Italy
    J Neurochem 109:371-81. 2009
    ..In conclusion, our data indicate that disruption of raft integrity causes a complex alteration of the endocannabinoid signalling in the striatum...
  25. ncbi request reprint Fatty acid amide hydrolase: a potential target for next generation therapeutics
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Italy
    Curr Pharm Des 12:759-72. 2006
    ..In addition, new insights into the promoter region of FAAH gene will be presented, and the therapeutic potential of mimetics of transcription factors of this gene in the management of human infertility will be discussed...
  26. ncbi request reprint New insights into endocannabinoid degradation and its therapeutic potential
    M Bari
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Mini Rev Med Chem 6:257-68. 2006
    ..Finally, the effects of inhibitors of endocannabinoid degradation in animal models of human disease will be reviewed, with an emphasis on their ongoing applications in anxiety, cancer and neurodegenerative disorders...
  27. ncbi request reprint Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Mol Hum Reprod 11:21-8. 2005
    ....
  28. ncbi request reprint Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages
    M Maccarrone
    Departments of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    J Neurochem 78:339-48. 2001
    ..Minor differences were observed in AEA or 2-arachidonoylglycerol content in knockout versus wild-type mice, whereas the other compounds were lower in the hippocampus of knockout versus wild-type animals...
  29. ncbi request reprint Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, Rome, I 00133, Italy
    Arch Biochem Biophys 393:321-8. 2001
    ..These results suggest that lymphocytes take part in regulating the peripheral endocannabinoid system and endocannabinoid homeostasis...
  30. ncbi request reprint Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences and Division of Obstetrics and Gynecology, University of Rome Tor Vergata, Rome, Italy
    J Immunol 166:7183-9. 2001
    ..These results add the endocannabinoids to the hormone-cytokine array involved in the control of human pregnancy...
  31. doi request reprint Evidence for the intracellular accumulation of anandamide in adiposomes
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Cell Mol Life Sci 65:840-50. 2008
    ..Overall, these findings suggest that adiposomes may have a critical role in accumulating anandamide, possibly by connecting plasma membrane to internal organelles along the metabolic route of this endocannabinoid...
  32. ncbi request reprint Endocannabinoids in adipocytes during differentiation and their role in glucose uptake
    V Gasperi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100, Teramo, Italy
    Cell Mol Life Sci 64:219-29. 2007
    ..We also show that AEA binding to peroxisome proliferator-activated receptor-gamma, known to induce differentiation of 3T3-L1 fibroblasts into adipocytes, is not involved in the stimulation of glucose uptake...
  33. ncbi request reprint Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    J Biol Chem 278:32726-32. 2003
    ..These findings might also have critical implications for human fertility...
  34. ncbi request reprint Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    J Biol Chem 275:31938-45. 2000
    ..The data presented indicate a protective role of cannabinoid receptors against apoptosis induced by AEA via vanilloid receptors...
  35. ncbi request reprint Gas chromatography-mass spectrometry analysis of endogenous cannabinoids in healthy and tumoral human brain and human cells in culture
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    J Neurochem 76:594-601. 2001
    ..These ex vivo results fully support the purported roles of endocannabinoids in the nervous system...
  36. ncbi request reprint Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis
    Monica Bari
    Department of Biomedical Sciences, University of Teramo, 64100 Teramo, Italy
    J Biol Chem 280:12212-20. 2005
    ..Altogether, the present data suggest that lipid rafts control CB1R binding and signaling, and that CB1R activation underlies the protective effect of MCD against apoptosis...
  37. ncbi request reprint Tryptic digestion of soybean lipoxygenase-1 generates a 60 kDa fragment with improved activity and membrane binding ability
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    Biochemistry 40:6819-27. 2001
    ....
  38. ncbi request reprint Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route
    M Maccarrone
    Departments of Experimental Medicine and Biochemical Sciences, Nephrology, and Surgery, Tor Vergata University, Rome, Italy
    Am J Kidney Dis 37:964-9. 2001
    ....
  39. doi request reprint TRPV1 channels facilitate glutamate transmission in the striatum
    Alessandra Musella
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Cell Neurosci 40:89-97. 2009
    ..TRPV1-mediated regulation of excitatory transmission in the striatum might be important for the final output to other basal ganglia structures, and might play a role in several physiological and pathological processes...
  40. ncbi request reprint Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo 64100, Italy
    Mol Hum Reprod 10:215-21. 2004
    ..The precise molecular identity of this activator, the first ever reported for FAAH, remains to be elucidated...
  41. doi request reprint Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction
    N Battista
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    J Neuroendocrinol 20:82-9. 2008
    ..In addition, we shall discuss the interplay between ECS, sex hormones and cytokines, which generates an endocannabinoid-hormone-cytokine array critically involved in the control of human reproduction...
  42. ncbi request reprint Oxidation products of polyamines induce mitochondrial uncoupling and cytochrome c release
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome 'Tor Vergata, Via di Tor Vergata 135, I-00133, Rome, Italy
    FEBS Lett 507:30-4. 2001
    ..Pargyline protected human lymphoma U937 cells against UVB-induced apoptosis, by reducing AO activity, mitochondrial uncoupling and cytochrome c release...
  43. ncbi request reprint Down-regulation of anandamide hydrolase in mouse uterus by sex hormones
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, and Department of Public Health and Cell Biology, University of Rome Tor Vergata, Italy
    Eur J Biochem 267:2991-7. 2000
    ..These findings may also be relevant for human fertility, as epithelial cells from healthy human uterus showed FAAH activity and expression, which in adenocarcinoma cells was increased fivefold...
  44. ncbi request reprint Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle
    N Lazzarin
    Department of Obstetrics and Gynecology, University of Rome Tor Vergata, Rome, Italy
    Gynecol Endocrinol 18:212-8. 2004
    ..This would add to our understanding of the pathophysiological and therapeutic implications of the endocannabinoid system in human fertility...
  45. ncbi request reprint Anandamide hydrolysis by human cells in culture and brain
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    J Biol Chem 273:32332-9. 1998
    ..min-1.mg of protein-1 (CHP100 cells) and 0.13 +/- 0.01 microM and 140 +/- 15 pmol.min-1.mg of protein-1 (U937 cells), respectively. The AnNH carrier of both cell lines was activated up to 170% of the control by nitric oxide...
  46. pmc Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Biochem J 366:137-44. 2002
    ..It seems noteworthy that degradation and pro-apoptotic activity of SEA are regulated by NO in a way opposite to that reported for AEA...
  47. ncbi request reprint Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells
    Monica Bari
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Immunol 177:4971-80. 2006
    ..In conclusion, the present data demonstrate that lipid rafts control CB1R, but not CB2R, and endocannabinoid transport in immune and neuronal cells...
  48. ncbi request reprint Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, Rome, Italy
    Eur J Neurosci 25:1631-40. 2007
    ..Our data support the concept that modulation of cannabinoid receptors might be useful against drug abuse...
  49. ncbi request reprint Endocannabinoids, hormone-cytokine networks and human fertility
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:309-17. 2002
    ....
  50. ncbi request reprint Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Cell Mol Life Sci 62:386-95. 2005
    ..These results provide the first morphological and biochemical evidence to support the view that transport and hydrolysis are two spatially and functionally distinct processes in AEA degradation...
  51. ncbi request reprint The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Brain 130:2543-53. 2007
    ..Our study suggests that targeting the endocannabinoid system might be useful for the treatment of MS...
  52. ncbi request reprint Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Eur J Neurosci 15:1178-86. 2002
    ....
  53. ncbi request reprint GPR55 and its interaction with membrane lipids: comparison with other endocannabinoid-binding receptors
    V Gasperi
    Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Curr Med Chem 20:64-78. 2013
    ....
  54. ncbi request reprint Anandamide uptake by human endothelial cells and its regulation by nitric oxide
    M Maccarrone
    Department of Experimental Medicine, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    J Biol Chem 275:13484-92. 2000
    ..HU-210 enhanced AEA uptake by HUVECs in a fashion sensitive to the NO synthase inhibitor Nomega-nitro-l-arginine methyl ester. These findings suggest a NO-mediated regulatory loop between CB(1) cannabinoid receptors and AEA transporter...
  55. ncbi request reprint Lipoxygenases and their involvement in programmed cell death
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    Cell Death Differ 8:776-84. 2001
    ..Finally, we discuss the role of lipoxygenase activation in apoptosis of animal and plant cells, suggesting a common signal transduction pathway in cell death conserved through evolution of both kingdoms...
  56. ncbi request reprint The catalytic efficiency of soybean lipoxygenase-1 is enhanced at low gravity
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    Biophys Chem 90:97-101. 2001
    ..Consequently, the catalytic efficiency of lipoxygenase-1 (k(cat)/Km) was approximately four-fold higher in flight than on ground. This unprecedented finding suggests that lipoxygenase-1 might be a molecular target for gravity...
  57. ncbi request reprint Endocannabinoid degradation, endotoxic shock and inflammation
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Curr Drug Targets Inflamm Allergy 1:53-63. 2002
    ..Taken together, it can be suggested that human lymphocytes and mast cells take part in regulating the peripheral endocannabinoid system, which can affect some activities of these cells...
  58. ncbi request reprint Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Cell Neurosci 35:302-10. 2007
    ..In conclusion, we have identified an mGlu-dependent mechanism of GABA transmission regulation of potential relevance for physiological neuronal activity...
  59. doi request reprint Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner
    Andrea Paradisi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo, Italy
    J Biol Chem 283:6005-12. 2008
    ..In fact, the modulation of DNA methylation by endocannabinoids may affect the expression of a number of genes that regulate many cell functions in response to these substances...
  60. pmc Characterization of the endocannabinoid system in human neuronal cells and proteomic analysis of anandamide-induced apoptosis
    Nicoletta Pasquariello
    Dipartimento di Scienze Biomediche, Università degli Studi di Teramo, 64100 Teramo, Italy
    J Biol Chem 284:29413-26. 2009
    ..Consistently, this effect of AEA was minimized by SR141716. In conclusion, we identified BiP as a key protein in neuronal apoptosis induced by AEA...
  61. doi request reprint High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation
    M Y Turco
    Department of Comparative Biomedical Sciences, University of Teramo 64100, Teramo, Italy
    Hum Reprod 23:2331-8. 2008
    ..We wanted to know whether the endocannabinoid signalling system was present also in the sheep reproductive tract and which kind of effect(s) AEA had on the development of sheep blastocysts in vitro...
  62. ncbi request reprint Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats
    Carlo Nucci
    Physiopathological Optics, Department of Biopathology and Diagnostic Imaging, University of Rome Tor Vergata, Rome, Italy
    Invest Ophthalmol Vis Sci 48:2997-3004. 2007
    ....
  63. doi request reprint Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol
    Maria Valeria Catani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Mol Med (Berl) 87:65-74. 2009
    ....
  64. ncbi request reprint The endocannabinoid system in neurodegeneration
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Ital J Biochem 55:283-9. 2006
    ..In addition, the potential exploitation of antagonists of endocannabinoid receptors, or of inhibitors of endocannabinoid metabolism, as next-generation therapeutics will be discussed...
  65. ncbi request reprint A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
    ..Understanding the molecular and physiological effects of drugs of abuse in the brain is essential for the development of effective strategies against addiction...
  66. ncbi request reprint The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    J Neurosci 27:8885-92. 2007
    ....
  67. doi request reprint Regulation of gene transcription and keratinocyte differentiation by anandamide
    Nicoletta Pasquariello
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Vitam Horm 81:441-67. 2009
    ..In addition, we review the role of AEA in the control of cornification, and show that it occurs by maintaining a transcriptional repression of gene expression through increased DNA methylation...
  68. ncbi request reprint N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors
    Silvia Marinelli
    Experimental Neurology, IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 32:298-308. 2007
    ..Moreover, they highlight a key function of the EMT transporter in promoting the stimulation of TRPV1 or CB1-R, thus favoring facilitation or inhibition of glutamate synaptic release...
  69. ncbi request reprint Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    Blood 100:4040-8. 2002
    ..Therefore, it is suggested that the peripheral actions of anandamide could be part of the molecular events responsible for the beneficial effects of estrogen...
  70. ncbi request reprint Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Italy
    Eur J Biochem 271:4666-76. 2004
    ....
  71. ncbi request reprint Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, I 00133 Rome, Italy
    Mol Hum Reprod 8:188-95. 2002
    ....
  72. doi request reprint Distinct regulation of nNOS and iNOS by CB2 receptor in remote delayed neurodegeneration
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, Teramo, Italy
    J Mol Med (Berl) 90:371-87. 2012
    ....
  73. ncbi request reprint The endocannabinoid system in ageing: a new target for drug development
    A Paradisi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Curr Drug Targets 7:1539-52. 2006
    ..In addition, the therapeutic potential of recently developed drugs able to modulate the endocannabinoid tone for the treatment of ageing and age-related human pathologies will be reviewed...
  74. ncbi request reprint Interaction of endocannabinoid receptors with biological membranes
    E Dainese
    Department of Biomedical Sciences, University of Teramo, Italy
    Curr Med Chem 17:1487-99. 2010
    ....
  75. ncbi request reprint Effect of denaturants on the structural properties of soybean lipoxygenase-1
    F Malvezzi-Campeggi
    INFM, University of Rome, Tor Vergata, Rome, I-00133, Italy
    Biochem Biophys Res Commun 289:1295-300. 2001
    ....
  76. doi request reprint Anandamide increases swelling and reduces calcium sensitivity of mitochondria
    Giuseppina Catanzaro
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
    Biochem Biophys Res Commun 388:439-42. 2009
    ..Overall, our data suggest that anandamide can impact mitochondrial physiology, by reducing calcium sensitivity and perturbing membrane properties of these organelles...
  77. ncbi request reprint Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo, Italy
    Neurobiol Dis 27:108-16. 2007
    ....
  78. ncbi request reprint Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells
    Valeria Gasperi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Neurotoxicology 26:811-7. 2005
    ..These findings might be relevant for the development of cell-selective drugs targeted towards FAAH...
  79. ncbi request reprint Endocannabinoids and their actions
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, I 00133 Rome, Italy
    Vitam Horm 65:225-55. 2002
    ..The main actions of the endocannabinoids in human cells and tissues will also be reviewed, focusing on the activities most recently discovered in the central nervous system and in the periphery...
  80. pmc Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors
    Maria Teresa Cencioni
    European Center for Brain Research CERC Santa Lucia Foundation, Rome, Italy
    PLoS ONE 5:e8688. 2010
    ..Not surprisingly, evidence has been accumulated showing manifold roles of endocannabinoids in the modulation of the immune system. However, details of such a modulation have not yet been disclosed in primary human T-cells...
  81. ncbi request reprint Cannabimimetic activity, binding, and degradation of stearoylethanolamide within the mouse central nervous system
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Mol Cell Neurosci 21:126-40. 2002
    ..Moreover, SEA potentiates the decrease of cAMP induced by AEA in mouse cortical slices, suggesting that SEA might also be an "entourage" compound...
  82. ncbi request reprint Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase
    Giampiero Mei
    INFM and Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 282:3829-36. 2007
    ..These findings suggest that local conformational changes at the level of the active site might induce a tighter interaction between the subunits of FAAH, affecting the enzymatic activity and the interaction with membranes...
  83. ncbi request reprint Cholesterol-dependent modulation of type 1 cannabinoid receptors in nerve cells
    Monica Bari
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    J Neurosci Res 81:275-83. 2005
    ..This observation may have important implications for the role of CB1R in protecting nerve cells against (endo)cannabinoid-induced apoptosis...
  84. doi request reprint 5-Lipoxygenase and cyclooxygenase-2 in the lungs of pigs naturally affected by enzootic pneumonia and porcine pleuropneumonia
    R Giacominelli-Stuffler
    Department of Comparative Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Res Vet Sci 93:898-903. 2012
    ..Consistently, increased enzyme activities were paralleled by increased leukotriene B(4) (LTB(4)), a 5-LOX product and prostaglandin E(2) (PGE(2)), a COX-2 product, content in diseased versus healthy lungs...
  85. doi request reprint Lipid-mediated dimerization of beta2-adrenergic receptor reveals important clues for cannabinoid receptors
    E Dainese
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, Teramo, Italy
    Cell Mol Life Sci 65:2277-9. 2008
    ..In addition, the implications of G protein coupled receptor dimerization, as well as the role of cholesterol in this process, are briefly discussed...
  86. pmc Cytotoxic effect of HIV-1 coat glycoprotein gp120 on human neuroblastoma CHP100 cells involves activation of the arachidonate cascade
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    Biochem J 333:45-9. 1998
    ..This suggests that NO might participate in the mechanism by which gp120 activates the arachidonate cascade...
  87. ncbi request reprint The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Cell Death Differ 10:946-55. 2003
    ..Also, recent findings on the apoptotic potential of AEA for neuronal cell differentiation and brain development will be discussed...
  88. ncbi request reprint Redox regulation in disease and ageing
    M Maccarrone
    Department of Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Italy
    Cell Death Differ 11:949-51. 2004
  89. doi request reprint 5-lipoxygenase and cyclooxygenase-2 in porcine parasitic bronchopneumonia: immunohistochemical and biochemical investigations
    G Marruchella
    Department of Comparative Biomedical Sciences, University of Teramo, Teramo, Italy
    J Comp Pathol 142:139-46. 2010
    ....
  90. ncbi request reprint The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    J Biol Chem 278:33896-903. 2003
    ....
  91. ncbi request reprint Inhibition of anandamide hydrolysis: cells also know how to do it
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, 64100 Teramo, Italy
    Trends Mol Med 10:13-4. 2004
  92. doi request reprint Methylation and acetylation of 15-hydroxyanandamide modulate its interaction with the endocannabinoid system
    Daniele Amadio
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    Biochimie 92:378-87. 2010
    ..Therefore, 15-MeOAEA is a FAAH inhibitor more selective than 15-HAEA. Further molecular dynamics analysis gave clues to the molecular requirements for the interaction of 15-HAEA and 15-MeOAEA with FAAH...
  93. doi request reprint Abnormal sensitivity of cannabinoid CB1 receptors in the striatum of mice with experimental amyotrophic lateral sclerosis
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Amyotroph Lateral Scler 11:83-90. 2010
    ..In conclusion, our data identify possible physiological correlates of striatal dysfunction in ALS mice, and suggest that cannabinoid CB1 receptors might be potential therapeutic targets for this dramatic disease...
  94. doi request reprint Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins
    Sergio Oddi
    Department of Biomedical Sciences, University of Teramo, Teramo 64100, Italy
    Chem Biol 16:624-32. 2009
    ..These findings suggest that the trafficking of anandamide from the plasma membrane to the internal compartments of a cell occur via a nonvesicular mechanism mediated by cytosolic carriers...
  95. ncbi request reprint Endocannabinoids and their involvement in the neurovascular system
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Curr Neurovasc Res 1:129-40. 2004
    ..In addition, the therapeutic potential of the modulation of endocannabinoid metabolism for neuronal and vascular system will be also reviewed...
  96. ncbi request reprint Enhanced anandamide degradation is associated with neuronal apoptosis induced by the HIV-1 coat glycoprotein gp120 in the rat neocortex
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    J Neurochem 89:1293-300. 2004
    ..Taken together, these results suggest that gp120, by activating FAAH, decreases endogenous levels of AEA, and the latter effect seems instrumental in the execution of delayed neuronal apoptosis in the brain neocortex of rats...
  97. ncbi request reprint Anandamide hydrolase: a guardian angel of human reproduction?
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Trends Pharmacol Sci 25:353-7. 2004
  98. ncbi request reprint Activation of human platelets by 2-arachidonoylglycerol is enhanced by serotonin
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Thromb Haemost 89:340-7. 2003
    ..Taken together, reported findings represent the first demonstration that 2-AG and 5-HT can mutually reinforce their receptor binding on platelet surface, which might have therapeutic implications...
  99. ncbi request reprint Modulation of the endocannabinoid system by lipid rafts
    Enrico Dainese
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Curr Med Chem 14:2702-15. 2007
    ..Finally, we also discuss the possible exploitation of LRs-targeted drugs as novel therapeutics for the treatment of endocannabinoid system-related pathologies...
  100. doi request reprint The endocannabinoid system in gp120-mediated insults and HIV-associated dementia
    Monica Bari
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Exp Neurol 224:74-84. 2010
    ....