M Maccarrone

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Eur J Neurosci 15:1178-86. 2002
  2. ncbi Tryptic digestion of soybean lipoxygenase-1 generates a 60 kDa fragment with improved activity and membrane binding ability
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    Biochemistry 40:6819-27. 2001
  3. ncbi Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages
    M Maccarrone
    Departments of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    J Neurochem 78:339-48. 2001
  4. ncbi Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences and Division of Obstetrics and Gynecology, University of Rome Tor Vergata, Rome, Italy
    J Immunol 166:7183-9. 2001
  5. ncbi Gas chromatography-mass spectrometry analysis of endogenous cannabinoids in healthy and tumoral human brain and human cells in culture
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    J Neurochem 76:594-601. 2001
  6. ncbi Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, Rome, I 00133, Italy
    Arch Biochem Biophys 393:321-8. 2001
  7. ncbi Down-regulation of anandamide hydrolase in mouse uterus by sex hormones
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, and Department of Public Health and Cell Biology, University of Rome Tor Vergata, Italy
    Eur J Biochem 267:2991-7. 2000
  8. ncbi Endocannabinoids, hormone-cytokine networks and human fertility
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:309-17. 2002
  9. ncbi Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle
    N Lazzarin
    Department of Obstetrics and Gynecology, University of Rome Tor Vergata, Rome, Italy
    Gynecol Endocrinol 18:212-8. 2004
  10. ncbi Anandamide uptake by human endothelial cells and its regulation by nitric oxide
    M Maccarrone
    Department of Experimental Medicine, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    J Biol Chem 275:13484-92. 2000

Collaborators

Detail Information

Publications49

  1. ncbi Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Eur J Neurosci 15:1178-86. 2002
    ....
  2. ncbi Tryptic digestion of soybean lipoxygenase-1 generates a 60 kDa fragment with improved activity and membrane binding ability
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    Biochemistry 40:6819-27. 2001
    ....
  3. ncbi Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages
    M Maccarrone
    Departments of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    J Neurochem 78:339-48. 2001
    ..Minor differences were observed in AEA or 2-arachidonoylglycerol content in knockout versus wild-type mice, whereas the other compounds were lower in the hippocampus of knockout versus wild-type animals...
  4. ncbi Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences and Division of Obstetrics and Gynecology, University of Rome Tor Vergata, Rome, Italy
    J Immunol 166:7183-9. 2001
    ..These results add the endocannabinoids to the hormone-cytokine array involved in the control of human pregnancy...
  5. ncbi Gas chromatography-mass spectrometry analysis of endogenous cannabinoids in healthy and tumoral human brain and human cells in culture
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    J Neurochem 76:594-601. 2001
    ..These ex vivo results fully support the purported roles of endocannabinoids in the nervous system...
  6. ncbi Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, Rome, I 00133, Italy
    Arch Biochem Biophys 393:321-8. 2001
    ..These results suggest that lymphocytes take part in regulating the peripheral endocannabinoid system and endocannabinoid homeostasis...
  7. ncbi Down-regulation of anandamide hydrolase in mouse uterus by sex hormones
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, and Department of Public Health and Cell Biology, University of Rome Tor Vergata, Italy
    Eur J Biochem 267:2991-7. 2000
    ..These findings may also be relevant for human fertility, as epithelial cells from healthy human uterus showed FAAH activity and expression, which in adenocarcinoma cells was increased fivefold...
  8. ncbi Endocannabinoids, hormone-cytokine networks and human fertility
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:309-17. 2002
    ....
  9. ncbi Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle
    N Lazzarin
    Department of Obstetrics and Gynecology, University of Rome Tor Vergata, Rome, Italy
    Gynecol Endocrinol 18:212-8. 2004
    ..This would add to our understanding of the pathophysiological and therapeutic implications of the endocannabinoid system in human fertility...
  10. ncbi Anandamide uptake by human endothelial cells and its regulation by nitric oxide
    M Maccarrone
    Department of Experimental Medicine, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    J Biol Chem 275:13484-92. 2000
    ..HU-210 enhanced AEA uptake by HUVECs in a fashion sensitive to the NO synthase inhibitor Nomega-nitro-l-arginine methyl ester. These findings suggest a NO-mediated regulatory loop between CB(1) cannabinoid receptors and AEA transporter...
  11. ncbi The catalytic efficiency of soybean lipoxygenase-1 is enhanced at low gravity
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    Biophys Chem 90:97-101. 2001
    ..Consequently, the catalytic efficiency of lipoxygenase-1 (k(cat)/Km) was approximately four-fold higher in flight than on ground. This unprecedented finding suggests that lipoxygenase-1 might be a molecular target for gravity...
  12. ncbi Oxidation products of polyamines induce mitochondrial uncoupling and cytochrome c release
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome 'Tor Vergata, Via di Tor Vergata 135, I-00133, Rome, Italy
    FEBS Lett 507:30-4. 2001
    ..Pargyline protected human lymphoma U937 cells against UVB-induced apoptosis, by reducing AO activity, mitochondrial uncoupling and cytochrome c release...
  13. ncbi Endocannabinoid degradation, endotoxic shock and inflammation
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I-00133 Rome, Italy
    Curr Drug Targets Inflamm Allergy 1:53-63. 2002
    ..Taken together, it can be suggested that human lymphocytes and mast cells take part in regulating the peripheral endocannabinoid system, which can affect some activities of these cells...
  14. ncbi Anandamide hydrolysis by human cells in culture and brain
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    J Biol Chem 273:32332-9. 1998
    ..min-1.mg of protein-1 (CHP100 cells) and 0.13 +/- 0.01 microM and 140 +/- 15 pmol.min-1.mg of protein-1 (U937 cells), respectively. The AnNH carrier of both cell lines was activated up to 170% of the control by nitric oxide...
  15. ncbi Lipoxygenases and their involvement in programmed cell death
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    Cell Death Differ 8:776-84. 2001
    ..Finally, we discuss the role of lipoxygenase activation in apoptosis of animal and plant cells, suggesting a common signal transduction pathway in cell death conserved through evolution of both kingdoms...
  16. ncbi Effect of denaturants on the structural properties of soybean lipoxygenase-1
    F Malvezzi-Campeggi
    INFM, University of Rome, Tor Vergata, Rome, I-00133, Italy
    Biochem Biophys Res Commun 289:1295-300. 2001
    ....
  17. ncbi Lipoxygenase activity during parabolic flights
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences and Biomedical Space Center, University of Rome Tor Vergata, Rome, Italy
    J Gravit Physiol 8:P123-4. 2001
    ..The aim was to ascertain whether microgravity can affect enzyme catalysis...
  18. ncbi Human platelets express authentic CB₁ and CB₂ receptors
    M V Catani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Curr Neurovasc Res 7:311-8. 2010
    ..It seems remarkable that some of these substances have been already used in humans to treat disease states...
  19. ncbi A sensitive and specific radiochromatographic assay of fatty acid amide hydrolase activity
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Anal Biochem 267:314-8. 1999
    ..The femtomole sensitivity and the accuracy of the method allow detection and characterization of the activity of FAAH in very minute tissue samples or in samples where the enzymatic activity is very low...
  20. ncbi Cytotoxic effect of HIV-1 coat glycoprotein gp120 on human neuroblastoma CHP100 cells involves activation of the arachidonate cascade
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    Biochem J 333:45-9. 1998
    ..This suggests that NO might participate in the mechanism by which gp120 activates the arachidonate cascade...
  21. ncbi Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route
    M Maccarrone
    Departments of Experimental Medicine and Biochemical Sciences, Nephrology, and Surgery, Tor Vergata University, Rome, Italy
    Am J Kidney Dis 37:964-9. 2001
    ....
  22. ncbi GPR55 and its interaction with membrane lipids: comparison with other endocannabinoid-binding receptors
    V Gasperi
    Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Curr Med Chem 20:64-78. 2013
    ....
  23. ncbi N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity
    M Taccone-Gallucci
    Section of Nephrology, Department of Biopathology and Imaging Techniques, Tor Vergata University, Rome, Italy
    Kidney Int 69:1450-4. 2006
    ..Upregulation of 5-Lox may also be related to the increased mitochondrial damage and apoptosis of PBMCs observed in ESRD patients compared to non-uremic controls. Omega-3 may thus protect PBMCs of ESRD patients against oxidative stress...
  24. ncbi Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol
    B Spoto
    CNR-IBIM, National Research Council Institute of Biomedicine-Clinical Epidemiology and Physiophatology of Renal Disease and Hypertension and Urology Unit, c/o Ki Point-Gransial Srl, Via Filippini, n.85, 89125 Reggio Calabria, Italy
    Biochimie 88:1889-97. 2006
    ..The data presented herein show for the first time that the human adipose tissue is able to bind AEA and 2-AG and that it is endowed with the biochemical machinery to metabolize endocannabinoids...
  25. ncbi The endocannabinoid system in ageing: a new target for drug development
    A Paradisi
    Department of Biomedical Sciences, University of Teramo, Piazza A. Moro 45, 64100 Teramo, Italy
    Curr Drug Targets 7:1539-52. 2006
    ..In addition, the therapeutic potential of recently developed drugs able to modulate the endocannabinoid tone for the treatment of ageing and age-related human pathologies will be reviewed...
  26. ncbi Endocannabinoids in adipocytes during differentiation and their role in glucose uptake
    V Gasperi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100, Teramo, Italy
    Cell Mol Life Sci 64:219-29. 2007
    ..We also show that AEA binding to peroxisome proliferator-activated receptor-gamma, known to induce differentiation of 3T3-L1 fibroblasts into adipocytes, is not involved in the stimulation of glucose uptake...
  27. ncbi Evidence for the intracellular accumulation of anandamide in adiposomes
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Cell Mol Life Sci 65:840-50. 2008
    ..Overall, these findings suggest that adiposomes may have a critical role in accumulating anandamide, possibly by connecting plasma membrane to internal organelles along the metabolic route of this endocannabinoid...
  28. ncbi Effects of cocaine in 5-lipoxygenase-deficient mice
    M Kurtuncu
    Department of Psychiatry, The Psychiatric Institute, University of Illinois, Chicago, IL, USA
    J Neural Transm 115:389-95. 2008
    ..Our results demonstrated that a 5-LOX deficiency alters sensitivity to repeated cocaine. It should be investigated whether a human 5-LOX gene polymorphism affects cocaine's actions...
  29. ncbi Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction
    N Battista
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    J Neuroendocrinol 20:82-9. 2008
    ..In addition, we shall discuss the interplay between ECS, sex hormones and cytokines, which generates an endocannabinoid-hormone-cytokine array critically involved in the control of human reproduction...
  30. ncbi New insights into endocannabinoid degradation and its therapeutic potential
    M Bari
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Mini Rev Med Chem 6:257-68. 2006
    ..Finally, the effects of inhibitors of endocannabinoid degradation in animal models of human disease will be reviewed, with an emphasis on their ongoing applications in anxiety, cancer and neurodegenerative disorders...
  31. ncbi Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases
    W B Veldhuis
    Department of Experimental In Vivo Nuclear Magnetic Resonance, Image Sciences Institute, Utrecht, The Netherlands
    J Neurosci 23:4127-33. 2003
    ....
  32. ncbi The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors
    T Bisogno
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico (VDM, TB, Arco Felice, Napoli, Italy
    Eur J Biochem 268:1982-9. 2001
    ....
  33. ncbi The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Cell Death Differ 10:946-55. 2003
    ..Also, recent findings on the apoptotic potential of AEA for neuronal cell differentiation and brain development will be discussed...
  34. ncbi Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs
    L M Cupini
    Centro Cefalee, Clinica Neurologica, Ospedale S Eugenio, Roma, Italy
    Cephalalgia 26:277-81. 2006
    ..The involvement of the endocannabinoid system in migraine is new and broadens our knowledge of this widespread and multifactorial disease...
  35. ncbi Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Mol Hum Reprod 11:21-8. 2005
    ....
  36. ncbi Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Piazza A. Moro 45, 64100 Teramo, Italy
    Cell Mol Life Sci 62:386-95. 2005
    ..These results provide the first morphological and biochemical evidence to support the view that transport and hydrolysis are two spatially and functionally distinct processes in AEA degradation...
  37. ncbi The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism
    L De Petrocellis
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico and the Istituto di Cibernetica, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    J Biol Chem 276:12856-63. 2001
    ..By contrast, the CB(1) receptor antagonist SR141716A inhibited also the VR1-mediated effect of anandamide and capsaicin on cytosolic Ca(2+) concentration, although at concentrations higher than those required for CB(1) antagonism...
  38. ncbi Lipid-mediated dimerization of beta2-adrenergic receptor reveals important clues for cannabinoid receptors
    E Dainese
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, Teramo, Italy
    Cell Mol Life Sci 65:2277-9. 2008
    ..In addition, the implications of G protein coupled receptor dimerization, as well as the role of cholesterol in this process, are briefly discussed...
  39. ncbi Degradation of endocannabinoids in chronic migraine and medication overuse headache
    L M Cupini
    U O C Neurologia, Dipartimento Cranio Spinale, Ospedale S Eugenio, Roma, Italy
    Neurobiol Dis 30:186-9. 2008
    ..Changes observed in the biochemical mechanisms degrading endogenous cannabinoids may reflect an adaptative behaviour induced by chronic headache and/or drug overuse...
  40. ncbi Exploitation of the HIV-1 coat glycoprotein, gp120, in neurodegenerative studies in vivo
    M T Corasaniti
    Faculty of Pharmacy, University of Catanzaro Magna Graecia and IBAF-CNR, Catanzaro, Italy
    J Neurochem 79:1-8. 2001
    ....
  41. ncbi Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions
    Z De March
    Laboratory of Neuroanatomy, Santa Lucia Foundation IRCCS at the European Center for Brain Research, Via del Fosso Fiorano 64, 00143 Rome, Italy
    Neuroscience 152:734-40. 2008
    ..We suggest that after excitotoxic lesions, CB1 might, at least transiently, upregulate BDNF in the attempt to rescue striatal neurons from degeneration...
  42. ncbi Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo 64100, Italy
    Mol Hum Reprod 10:215-21. 2004
    ..The precise molecular identity of this activator, the first ever reported for FAAH, remains to be elucidated...
  43. ncbi 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
    P Massi
    Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Milan, Italy
    J Neurochem 104:1091-100. 2008
    ....
  44. ncbi Good news for CB1 receptors: endogenous agonists are in the right place
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Br J Pharmacol 153:179-81. 2008
    ..It also raises an important question about the structural determinants responsible for a different localization of two apparently similar endocannabinoids within lipid bilayers...
  45. ncbi Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex
    T Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Cereb Cortex 18:1292-301. 2008
    ....
  46. ncbi CB2 receptors in reproduction
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Br J Pharmacol 153:189-98. 2008
    ..It is hoped that CB2-dependent endocannabinoid signalling might become a useful target for correcting infertility, in both men and women...
  47. ncbi Redox regulation in disease and ageing
    M Maccarrone
    Department of Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Italy
    Cell Death Differ 11:949-51. 2004
  48. ncbi Effect of simulated microgravity on PGE2-induced edema and hyperalgesia in rat paws: pharmacological data and biochemical correlates
    A T Peana
    Dipartimento di Scienze del Farmaco,
    J Gravit Physiol 11:P41-2. 2004
    ..These results showed that RPM diminished the levels of PGE2 in exudates of paws previously treated with PGE2, but did not influence the iNOS expression...
  49. ncbi Biological abnormalities of peripheral A(2A) receptors in a large representation of polyglutamine disorders and Huntington's disease stages
    K Varani
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Italy
    Neurobiol Dis 27:36-43. 2007
    ....