M Maccarrone

Summary

Affiliation: University of Teramo
Country: Italy

Publications

  1. ncbi request reprint The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    J Biol Chem 278:33896-903. 2003
  2. ncbi request reprint Inhibition of anandamide hydrolysis: cells also know how to do it
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, 64100 Teramo, Italy
    Trends Mol Med 10:13-4. 2004
  3. ncbi request reprint Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Mol Hum Reprod 11:21-8. 2005
  4. ncbi request reprint Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo 64100, Italy
    Mol Hum Reprod 10:215-21. 2004
  5. ncbi request reprint Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Italy
    J Leukoc Biol 73:472-81. 2003
  6. ncbi request reprint Activation of human platelets by 2-arachidonoylglycerol is enhanced by serotonin
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Thromb Haemost 89:340-7. 2003
  7. ncbi request reprint Leptin activates the anandamide hydrolase promoter in human T lymphocytes through STAT3
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    J Biol Chem 278:13318-24. 2003
  8. ncbi request reprint The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Cell Death Differ 10:946-55. 2003
  9. ncbi request reprint Anandamide hydrolase: a guardian angel of human reproduction?
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Trends Pharmacol Sci 25:353-7. 2004
  10. doi request reprint Evidence for the intracellular accumulation of anandamide in adiposomes
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Cell Mol Life Sci 65:840-50. 2008

Collaborators

Detail Information

Publications82

  1. ncbi request reprint The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    J Biol Chem 278:33896-903. 2003
    ....
  2. ncbi request reprint Inhibition of anandamide hydrolysis: cells also know how to do it
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, 64100 Teramo, Italy
    Trends Mol Med 10:13-4. 2004
  3. ncbi request reprint Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Mol Hum Reprod 11:21-8. 2005
    ....
  4. ncbi request reprint Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo 64100, Italy
    Mol Hum Reprod 10:215-21. 2004
    ..The precise molecular identity of this activator, the first ever reported for FAAH, remains to be elucidated...
  5. ncbi request reprint Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Italy
    J Leukoc Biol 73:472-81. 2003
    ..Finally, creating conditions similar to those that occur during exposure of cells to microgravity did not induce apoptosis in human lymphoma U937 cells, which did not express an active 5-LOX...
  6. ncbi request reprint Activation of human platelets by 2-arachidonoylglycerol is enhanced by serotonin
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Thromb Haemost 89:340-7. 2003
    ..Taken together, reported findings represent the first demonstration that 2-AG and 5-HT can mutually reinforce their receptor binding on platelet surface, which might have therapeutic implications...
  7. ncbi request reprint Leptin activates the anandamide hydrolase promoter in human T lymphocytes through STAT3
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    J Biol Chem 278:13318-24. 2003
    ..These findings might also have critical implications for human fertility...
  8. ncbi request reprint The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Cell Death Differ 10:946-55. 2003
    ..Also, recent findings on the apoptotic potential of AEA for neuronal cell differentiation and brain development will be discussed...
  9. ncbi request reprint Anandamide hydrolase: a guardian angel of human reproduction?
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Trends Pharmacol Sci 25:353-7. 2004
  10. doi request reprint Evidence for the intracellular accumulation of anandamide in adiposomes
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Cell Mol Life Sci 65:840-50. 2008
    ..Overall, these findings suggest that adiposomes may have a critical role in accumulating anandamide, possibly by connecting plasma membrane to internal organelles along the metabolic route of this endocannabinoid...
  11. ncbi request reprint New insights into endocannabinoid degradation and its therapeutic potential
    M Bari
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Mini Rev Med Chem 6:257-68. 2006
    ..Finally, the effects of inhibitors of endocannabinoid degradation in animal models of human disease will be reviewed, with an emphasis on their ongoing applications in anxiety, cancer and neurodegenerative disorders...
  12. ncbi request reprint Endocannabinoids in adipocytes during differentiation and their role in glucose uptake
    V Gasperi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100, Teramo, Italy
    Cell Mol Life Sci 64:219-29. 2007
    ..We also show that AEA binding to peroxisome proliferator-activated receptor-gamma, known to induce differentiation of 3T3-L1 fibroblasts into adipocytes, is not involved in the stimulation of glucose uptake...
  13. ncbi request reprint Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Cell Mol Life Sci 62:386-95. 2005
    ..These results provide the first morphological and biochemical evidence to support the view that transport and hydrolysis are two spatially and functionally distinct processes in AEA degradation...
  14. doi request reprint Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction
    N Battista
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    J Neuroendocrinol 20:82-9. 2008
    ..In addition, we shall discuss the interplay between ECS, sex hormones and cytokines, which generates an endocannabinoid-hormone-cytokine array critically involved in the control of human reproduction...
  15. doi request reprint High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation
    M Y Turco
    Department of Comparative Biomedical Sciences, University of Teramo 64100, Teramo, Italy
    Hum Reprod 23:2331-8. 2008
    ..We wanted to know whether the endocannabinoid signalling system was present also in the sheep reproductive tract and which kind of effect(s) AEA had on the development of sheep blastocysts in vitro...
  16. ncbi request reprint Interaction of endocannabinoid receptors with biological membranes
    E Dainese
    Department of Biomedical Sciences, University of Teramo, Italy
    Curr Med Chem 17:1487-99. 2010
    ....
  17. doi request reprint 5-Lipoxygenase and cyclooxygenase-2 in the lungs of pigs naturally affected by enzootic pneumonia and porcine pleuropneumonia
    R Giacominelli-Stuffler
    Department of Comparative Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Res Vet Sci 93:898-903. 2012
    ..Consistently, increased enzyme activities were paralleled by increased leukotriene B(4) (LTB(4)), a 5-LOX product and prostaglandin E(2) (PGE(2)), a COX-2 product, content in diseased versus healthy lungs...
  18. ncbi request reprint Human platelets express authentic CB₁ and CB₂ receptors
    M V Catani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Curr Neurovasc Res 7:311-8. 2010
    ..It seems remarkable that some of these substances have been already used in humans to treat disease states...
  19. ncbi request reprint Redox regulation in disease and ageing
    M Maccarrone
    Department of Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Italy
    Cell Death Differ 11:949-51. 2004
  20. ncbi request reprint N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity
    M Taccone-Gallucci
    Section of Nephrology, Department of Biopathology and Imaging Techniques, Tor Vergata University, Rome, Italy
    Kidney Int 69:1450-4. 2006
    ..Upregulation of 5-Lox may also be related to the increased mitochondrial damage and apoptosis of PBMCs observed in ESRD patients compared to non-uremic controls. Omega-3 may thus protect PBMCs of ESRD patients against oxidative stress...
  21. ncbi request reprint The endocannabinoid system in ageing: a new target for drug development
    A Paradisi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Curr Drug Targets 7:1539-52. 2006
    ..In addition, the therapeutic potential of recently developed drugs able to modulate the endocannabinoid tone for the treatment of ageing and age-related human pathologies will be reviewed...
  22. doi request reprint Lipid-mediated dimerization of beta2-adrenergic receptor reveals important clues for cannabinoid receptors
    E Dainese
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, Teramo, Italy
    Cell Mol Life Sci 65:2277-9. 2008
    ..In addition, the implications of G protein coupled receptor dimerization, as well as the role of cholesterol in this process, are briefly discussed...
  23. doi request reprint Distinct regulation of nNOS and iNOS by CB2 receptor in remote delayed neurodegeneration
    S Oddi
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, Teramo, Italy
    J Mol Med (Berl) 90:371-87. 2012
    ....
  24. doi request reprint 5-lipoxygenase and cyclooxygenase-2 in porcine parasitic bronchopneumonia: immunohistochemical and biochemical investigations
    G Marruchella
    Department of Comparative Biomedical Sciences, University of Teramo, Teramo, Italy
    J Comp Pathol 142:139-46. 2010
    ....
  25. pmc Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo 64100, Italy
    Br J Pharmacol 163:1379-90. 2011
    ..The results of these investigations might be exploited also for the development of novel therapeutics able to combat disorders associated with abnormal activity of CB(1)...
  26. pmc CB2 receptors in reproduction
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Br J Pharmacol 153:189-98. 2008
    ..It is hoped that CB2-dependent endocannabinoid signalling might become a useful target for correcting infertility, in both men and women...
  27. doi request reprint Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system
    S E M Lewis
    Centre for Public Health, Institute of Clinical Science, Queens University of Belfast, Belfast, UK
    Int J Androl 35:731-40. 2012
    ..HU210, a selective agonist for CB1 and CB2 cannabinoid receptors impairs spermatogenesis and sperm motility and deregulates the endocannabinoid system...
  28. ncbi request reprint Redox regulation by ischemia/reperfusion
    M Maccarrone
    Department of Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy
    Cell Death Differ 13:2002-3. 2006
  29. pmc Good news for CB1 receptors: endogenous agonists are in the right place
    M Maccarrone
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Br J Pharmacol 153:179-81. 2008
    ..It also raises an important question about the structural determinants responsible for a different localization of two apparently similar endocannabinoids within lipid bilayers...
  30. ncbi request reprint The endocannabinoid pathway in Huntington's disease: a comparison with other neurodegenerative diseases
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Prog Neurobiol 81:349-79. 2007
    ..Also the plastic changes of endocannabinoids in multiple sclerosis will be reviewed, as a paradigm of their impact in neuroinflammatory disorders...
  31. ncbi request reprint Antagonism of type-1 cannabinoid receptors: good for obesity, but is it safe for fertility?
    Mauro Maccarrone
    Clin Endocrinol (Oxf) 66:456-7. 2007
  32. doi request reprint Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
    Mauro Maccarrone
    Dipartimento di Scienze Biomediche, Università degli Studi di Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
    Nat Neurosci 11:152-9. 2008
    ..Consistently, the interaction between AEA and 2-AG was lost after pharmacological and genetic inactivation of TRPV1 channels...
  33. doi request reprint Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner
    Andrea Paradisi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo, Italy
    J Biol Chem 283:6005-12. 2008
    ..In fact, the modulation of DNA methylation by endocannabinoids may affect the expression of a number of genes that regulate many cell functions in response to these substances...
  34. ncbi request reprint The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    J Neurosci 27:8885-92. 2007
    ....
  35. ncbi request reprint The endocannabinoid system in neurodegeneration
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    Ital J Biochem 55:283-9. 2006
    ..In addition, the potential exploitation of antagonists of endocannabinoid receptors, or of inhibitors of endocannabinoid metabolism, as next-generation therapeutics will be discussed...
  36. ncbi request reprint Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Italy
    Eur J Biochem 271:4666-76. 2004
    ....
  37. ncbi request reprint Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase
    Giampiero Mei
    INFM and Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 282:3829-36. 2007
    ..These findings suggest that local conformational changes at the level of the active site might induce a tighter interaction between the subunits of FAAH, affecting the enzymatic activity and the interaction with membranes...
  38. ncbi request reprint Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, Rome, Italy
    Eur J Neurosci 25:1631-40. 2007
    ..Our data support the concept that modulation of cannabinoid receptors might be useful against drug abuse...
  39. ncbi request reprint Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Cell Neurosci 35:302-10. 2007
    ..In conclusion, we have identified an mGlu-dependent mechanism of GABA transmission regulation of potential relevance for physiological neuronal activity...
  40. ncbi request reprint Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo, Italy
    Neurobiol Dis 27:108-16. 2007
    ....
  41. doi request reprint FAAH and anandamide: is 2-AG really the odd one out?
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, Italy
    Trends Pharmacol Sci 29:229-33. 2008
    ....
  42. ncbi request reprint Acute neuronal injury, excitotoxicity, and the endocannabinoid system
    Mario Van Der Stelt
    Department of Bio Organic Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands
    Mol Neurobiol 26:317-46. 2002
    ..However, several observations indicate that the role of the endocannabinoid system as a general endogenous protection system is questionable. The data are critically reviewed and possible explanations are given...
  43. ncbi request reprint Modulation of the endocannabinoid system by lipid rafts
    Enrico Dainese
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Curr Med Chem 14:2702-15. 2007
    ..Finally, we also discuss the possible exploitation of LRs-targeted drugs as novel therapeutics for the treatment of endocannabinoid system-related pathologies...
  44. ncbi request reprint Endocannabinoid signaling and neuroinflammatory diseases
    Mauro Maccarrone
    Curr Pharm Des 14:2252-3. 2008
  45. ncbi request reprint Effect of RNAlater on lipoxygenase activity and expression, and immune cell apoptosis: opening the gate to the "ROALD" experiment aboard the space shuttle
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Piazz A Moro 45, 64100 Teramo, Italy
    J Gravit Physiol 14:P131-2. 2007
  46. ncbi request reprint The endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases
    Diego Centonze
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Curr Pharm Des 14:2370-42. 2008
    ....
  47. ncbi request reprint Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2
    M Paola Castelli
    Bernard B Brodie Department of Neuroscience, University of Cagliari, 09042 Monserrato, Italy
    Eur J Pharmacol 573:11-9. 2007
    ..Our results show that prenatal exposure to cannabinoid agonist induces a long-term alteration of endocannabinoid system in brain areas involved in learning-memory, motor activity and emotional behavior...
  48. ncbi request reprint The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Brain 130:2543-53. 2007
    ..Our study suggests that targeting the endocannabinoid system might be useful for the treatment of MS...
  49. ncbi request reprint Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats
    Carlo Nucci
    Physiopathological Optics, Department of Biopathology and Diagnostic Imaging, University of Rome Tor Vergata, Rome, Italy
    Invest Ophthalmol Vis Sci 48:2997-3004. 2007
    ....
  50. ncbi request reprint Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells
    Gianna Rossi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Endocrinology 148:1431-9. 2007
    ..Altogether these data suggest that FAAH is the only target of FSH among the elements of the endocannabinoid system, and that its regulation by PKA and aromatase-dependent pathways impacts Sertoli cell proliferation...
  51. ncbi request reprint Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells
    Monica Bari
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Immunol 177:4971-80. 2006
    ..In conclusion, the present data demonstrate that lipid rafts control CB1R, but not CB2R, and endocannabinoid transport in immune and neuronal cells...
  52. ncbi request reprint Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    J Biol Chem 278:32726-32. 2003
    ..These findings might also have critical implications for human fertility...
  53. ncbi request reprint Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors
    Silvia Marinelli
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, University of Tor Vergata, 00179 Rome, Italy
    J Neurosci 23:3136-44. 2003
    ..The increase in sEPSC frequency by VR1 onto midbrain dopaminergic neurons suggests the involvement of these receptors in motor and cognitive functions involving the dopaminergic system...
  54. ncbi request reprint Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism
    Mauro Maccarrone
    Dipartimento di Medicina Sperimentale e Scienze Biochimiche and Dipartimento di Neuroscienze, Universita degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurochem 85:1018-25. 2003
    ....
  55. ncbi request reprint Structure-to-function relationship of mini-lipoxygenase, a 60-kDa fragment of soybean lipoxygenase-1 with lower stability but higher enzymatic activity
    Almerinda Di Venere
    INFM, 16152 Genova, Italy
    J Biol Chem 278:18281-8. 2003
    ..These findings strongly support the hypothesis that the larger hydration of mini-Lox renders this molecule more flexible, and therefore less stable...
  56. ncbi request reprint Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, I 00133 Italy
    Endocrinology 144:20-8. 2003
    ..Taken together, it can be suggested that the endocannabinoid network plays a role in the hormonal regulation of male fertility...
  57. ncbi request reprint Endocannabinoids and their actions
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, I 00133 Rome, Italy
    Vitam Horm 65:225-55. 2002
    ..The main actions of the endocannabinoids in human cells and tissues will also be reviewed, focusing on the activities most recently discovered in the central nervous system and in the periphery...
  58. ncbi request reprint Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    Blood 100:4040-8. 2002
    ..Therefore, it is suggested that the peripheral actions of anandamide could be part of the molecular events responsible for the beneficial effects of estrogen...
  59. ncbi request reprint Cannabimimetic activity, binding, and degradation of stearoylethanolamide within the mouse central nervous system
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Mol Cell Neurosci 21:126-40. 2002
    ..Moreover, SEA potentiates the decrease of cAMP induced by AEA in mouse cortical slices, suggesting that SEA might also be an "entourage" compound...
  60. ncbi request reprint Cholesterol-dependent modulation of the toxicity of HIV-1 coat protein gp120 in human neuroblastoma cells
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 82:1444-52. 2002
    ..Taken together, these results suggest that membrane fluidity may control the neurotoxic effects of HIV-1 glycoprotein gp120...
  61. ncbi request reprint Arachidonate cascade, apoptosis, and vitamin E in peripheral blood mononuclear cells from hemodialysis patients
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Am J Kidney Dis 40:600-10. 2002
    ..5-Lipoxygenase activity is specifically inhibited by vitamin E both in vitro and in vivo regardless of its administration route...
  62. ncbi request reprint Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission
    Paolo Gubellini
    Dipartimentos di Neuroscienze, Universita degli Studi di Roma Tor Vergata, 00133 Roma, Italy
    J Neurosci 22:6900-7. 2002
    ..The present study shows that inhibition of anandamide hydrolysis might represent a possible target to decrease the abnormal cortical glutamatergic drive in Parkinson's disease...
  63. ncbi request reprint Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase
    Mario Van Der Stelt
    Department of Bio Organic Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands
    J Med Chem 45:3709-20. 2002
    ..The MD simulations may suggest that the average orientations of the pentyl tail of AEA and 12(S)-hydroxy-eicosa-5Z,8Z,10E,14Z-tetraenoyl-N-(2-hydroxyethyl)amine are different from that of the low-affinity, inactive ligands...
  64. pmc Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Biochem J 366:137-44. 2002
    ..It seems noteworthy that degradation and pro-apoptotic activity of SEA are regulated by NO in a way opposite to that reported for AEA...
  65. ncbi request reprint Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Eur J Neurosci 15:1178-86. 2002
    ....
  66. ncbi request reprint Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, I 00133 Rome, Italy
    Mol Hum Reprod 8:188-95. 2002
    ....
  67. ncbi request reprint The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner
    Meritxell Alberich Jorda
    Erasmus MC, Department of Hematology, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Blood 104:526-34. 2004
    ..This indicates a unique mechanism by which a transforming GPCR, in a ligand-dependent manner, causes 2 distinct oncogenic effects: altered migration and block of neutrophilic development...
  68. ncbi request reprint N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors
    Silvia Marinelli
    Experimental Neurology, IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 32:298-308. 2007
    ..Moreover, they highlight a key function of the EMT transporter in promoting the stimulation of TRPV1 or CB1-R, thus favoring facilitation or inhibition of glutamate synaptic release...
  69. ncbi request reprint Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Thromb Haemost 95:117-27. 2006
    ....
  70. ncbi request reprint Fatty acid amide hydrolase: a potential target for next generation therapeutics
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Italy
    Curr Pharm Des 12:759-72. 2006
    ..In addition, new insights into the promoter region of FAAH gene will be presented, and the therapeutic potential of mimetics of transcription factors of this gene in the management of human infertility will be discussed...
  71. ncbi request reprint The photoreceptor protector zeaxanthin induces cell death in neuroblastoma cells
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Anticancer Res 25:3871-6. 2005
    ..Since zeaxanthin can inhibit lipid peroxidation and beta-carotene inhibits lipoxygenase (LOX) activity, it was of concern that zeaxanthin might inhibit apoptosis in these cancer cells...
  72. ncbi request reprint Endocannabinoids and their involvement in the neurovascular system
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Curr Neurovasc Res 1:129-40. 2004
    ..In addition, the therapeutic potential of the modulation of endocannabinoid metabolism for neuronal and vascular system will be also reviewed...
  73. ncbi request reprint Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells
    Valeria Gasperi
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy
    Neurotoxicology 26:811-7. 2005
    ..These findings might be relevant for the development of cell-selective drugs targeted towards FAAH...
  74. ncbi request reprint Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Pizza A Moro 45, 64100 Teramo, Italy
    J Cell Sci 118:4393-404. 2005
    ..These observations open new perspectives on the understanding and treatment of male fertility problems...
  75. ncbi request reprint Central and peripheral interactions between endocannabinoids and steroids, and implications for drug dependence
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    Life Sci 77:1559-68. 2005
    ..Finally, I present the hypothesis that retrograde endocannabinoid signaling, by reducing striatal glutamate release, may be part of the molecular events responsible for the influence of steroids on drug abuse...
  76. ncbi request reprint Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Italy
    Biol Psychiatry 57:1583-9. 2005
    ..How this alteration impacts striatal synaptic transmission is unknown...
  77. ncbi request reprint Cholesterol-dependent modulation of type 1 cannabinoid receptors in nerve cells
    Monica Bari
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    J Neurosci Res 81:275-83. 2005
    ..This observation may have important implications for the role of CB1R in protecting nerve cells against (endo)cannabinoid-induced apoptosis...
  78. ncbi request reprint Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis
    Monica Bari
    Department of Biomedical Sciences, University of Teramo, 64100 Teramo, Italy
    J Biol Chem 280:12212-20. 2005
    ..Altogether, the present data suggest that lipid rafts control CB1R binding and signaling, and that CB1R activation underlies the protective effect of MCD against apoptosis...
  79. ncbi request reprint Morphological evidence that 2-arachidonoylglycerol is a true agonist of human platelets
    Walter Malorni
    Thromb Haemost 92:1159-61. 2004
  80. ncbi request reprint Enhanced anandamide degradation is associated with neuronal apoptosis induced by the HIV-1 coat glycoprotein gp120 in the rat neocortex
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, I 64100 Teramo, Italy
    J Neurochem 89:1293-300. 2004
    ..Taken together, these results suggest that gp120, by activating FAAH, decreases endogenous levels of AEA, and the latter effect seems instrumental in the execution of delayed neuronal apoptosis in the brain neocortex of rats...
  81. ncbi request reprint A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
    ..Understanding the molecular and physiological effects of drugs of abuse in the brain is essential for the development of effective strategies against addiction...
  82. ncbi request reprint Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol
    Meritxell Alberich Jorda
    Institute for Hematology, Erasmus University Rotterdam, The Netherlands
    Blood 99:2786-93. 2002
    ..Our study demonstrates that a major function of Cb2 receptor expressed on myeloid leukemia cells or normal splenocytes is stimulation of migration...