Rita Maccario

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi request reprint Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype
    Rita Maccario
    Laboratorio di Immunologia dei Trapianti, Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, P le Golgi 19, 27100 Pavia, Italy
    Haematologica 90:516-25. 2005
  2. ncbi request reprint Gene transfer of HA-1 specificity
    Rita Maccario
    Laboratorio di Ricerca Immunologia dei Trapianti, Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy
    Haematologica 90:1303B. 2005
  3. pmc Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors
    Maria Antonietta Avanzini
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Haematologica 94:1649-60. 2009
  4. ncbi request reprint Treatment of EBV-related post-renal transplant lymphoproliferative disease with a tailored regimen including EBV-specific T cells
    Patrizia Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico S Matteo, Pavia, Italy
    Am J Transplant 5:1415-22. 2005
  5. doi request reprint Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Cytotherapy 11:825-36. 2009
  6. ncbi request reprint Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation
    Patrizia Comoli
    Laboratorio Sperimentale di Trapianto di Midollo Osseo, Oncoematologia Pediatrica, Fondazione IRCCS Policlinico S Matteo, Universita di Pavia, V le Golgi 19, 27100 Pavia, Italy
    Nephrol Dial Transplant 23:1196-202. 2008
  7. doi request reprint Cell-cycle phases and genetic profile of bone marrow-derived mesenchymal stromal cells expanded in vitro from healthy donors
    Valentina Achille
    Unità di Epidemiologia Clinica, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    J Cell Biochem 112:1817-21. 2011
  8. doi request reprint Donor/recipient mixed chimerism does not predict graft failure in children with beta-thalassemia given an allogeneic cord blood transplant from an HLA-identical sibling
    Daniela Lisini
    Oncoematologia Pediatrica, Laboratorio di Immunologia dei Trapianti, Fondazione IRCCS Policlinico San Matteo, P le Golgi, 2, I 27100 Pavia, Italy
    Haematologica 93:1859-67. 2008
  9. ncbi request reprint Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes
    Patrizia Comoli
    Laboratorio di Ricerca Area Trapianti e Oncoematologia Pediatrica, IRCCS Policlinico S Matteo, V le Golgi 19, 27100 Pavia, Italy
    J Clin Oncol 23:8942-9. 2005
  10. ncbi request reprint Polyomavirus BK-specific immunity after kidney transplantation
    Patrizia Comoli
    Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy
    Transplantation 78:1229-32. 2004

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype
    Rita Maccario
    Laboratorio di Immunologia dei Trapianti, Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, P le Golgi 19, 27100 Pavia, Italy
    Haematologica 90:516-25. 2005
    ..We extended the evaluation of mechanisms responsible for the immune regulatory effect derived from the interaction of human MSC with cells involved in alloantigen-specific immune response in mixed lymphocyte culture (MLC)...
  2. ncbi request reprint Gene transfer of HA-1 specificity
    Rita Maccario
    Laboratorio di Ricerca Immunologia dei Trapianti, Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy
    Haematologica 90:1303B. 2005
  3. pmc Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors
    Maria Antonietta Avanzini
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Haematologica 94:1649-60. 2009
    ..However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be influenced by both the cell source and culture conditions...
  4. ncbi request reprint Treatment of EBV-related post-renal transplant lymphoproliferative disease with a tailored regimen including EBV-specific T cells
    Patrizia Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico S Matteo, Pavia, Italy
    Am J Transplant 5:1415-22. 2005
    ..These preliminary results suggest that a combined chemoimmunotherapy regimen including virus-specific T-cells is well tolerated and potentially effective as first-line treatment of EBV-related PTLD...
  5. doi request reprint Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Cytotherapy 11:825-36. 2009
    ..The aim of the study was in vitro characterization of MSC from active CD patients for future clinical application...
  6. ncbi request reprint Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation
    Patrizia Comoli
    Laboratorio Sperimentale di Trapianto di Midollo Osseo, Oncoematologia Pediatrica, Fondazione IRCCS Policlinico S Matteo, Universita di Pavia, V le Golgi 19, 27100 Pavia, Italy
    Nephrol Dial Transplant 23:1196-202. 2008
    ..Mesenchymal stem cells (MSCs) have immunomodulatory capacity, since in vivo they may prolong skin graft survival in the animal model and can rescue patients with life-threatening graft-versus-host disease...
  7. doi request reprint Cell-cycle phases and genetic profile of bone marrow-derived mesenchymal stromal cells expanded in vitro from healthy donors
    Valentina Achille
    Unità di Epidemiologia Clinica, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    J Cell Biochem 112:1817-21. 2011
    ..Cytogenetic analysis on synchronous MSCs allowed us to obtain 20-25 valuable metaphases/slide, whereas only 0-4 metaphases/slide were detectable in asynchronous preparations...
  8. doi request reprint Donor/recipient mixed chimerism does not predict graft failure in children with beta-thalassemia given an allogeneic cord blood transplant from an HLA-identical sibling
    Daniela Lisini
    Oncoematologia Pediatrica, Laboratorio di Immunologia dei Trapianti, Fondazione IRCCS Policlinico San Matteo, P le Golgi, 2, I 27100 Pavia, Italy
    Haematologica 93:1859-67. 2008
    ..We investigated the relationship between the degree of mixed chimerism over time and clinical outcome of children undergoing cord blood transplantation for beta-thalassemia...
  9. ncbi request reprint Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes
    Patrizia Comoli
    Laboratorio di Ricerca Area Trapianti e Oncoematologia Pediatrica, IRCCS Policlinico S Matteo, V le Golgi 19, 27100 Pavia, Italy
    J Clin Oncol 23:8942-9. 2005
    ..We conducted a clinical trial of EBV-targeted cell therapy with autologous virus-specific cytotoxic T lymphocytes (CTLs) for NPC refractory to conventional treatments...
  10. ncbi request reprint Polyomavirus BK-specific immunity after kidney transplantation
    Patrizia Comoli
    Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy
    Transplantation 78:1229-32. 2004
    ..Our preliminary data suggest that lack of protective immunity toward BKV may favor the occurrence of BKV active infection and influence the progression to PVAN...
  11. ncbi request reprint Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia
    Daniela Montagna
    Dipartimento di Scienze Pediatriche, Universita di Pavia, IRCCS Policlinico San Matteo, P le Golgi 2, 27100 Pavia, Italy
    Blood 108:3843-50. 2006
    ....
  12. ncbi request reprint Variations of the perforin gene in patients with autoimmunity/lymphoproliferation and defective Fas function
    Rita Clementi
    Pediatric Haematology Oncology, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Blood 108:3079-84. 2006
    ..A91V patients displayed lower NK activity than controls. These data suggest that perforin variations are a susceptibility factor for ALPS/DALD development in subjects with defective Fas function and may influence disease expression...
  13. doi request reprint In vitro evaluation of graft-versus-graft alloreactivity as a tool to identify the predominant cord blood unit before double cord blood transplantation
    Antonia Moretta
    Laboratory of Pediatric Immunology and Onco Hematology Transplant, Infant Maternal Department, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 19, Pavia, Italy
    Biol Blood Marrow Transplant 18:1108-18. 2012
    ....
  14. ncbi request reprint Low percentages of circulating CD8(+)/CD45RA(+) human T lymphocytes expressing beta7 integrin correlate with the occurrence of intestinal acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    M Antonietta Avanzini
    Pediatric Hematology Oncology and Laboratory of Transplant Immunology, IRCCS Policlinico San Matteo Pavia, University of Pavia, Pavia, Italy
    Exp Hematol 34:1429-34. 2006
    ..Therefore, we evaluated the correlation existing between circulating beta7(+) T-lymphocyte subsets early after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and occurrence of a-GVHD...
  15. doi request reprint Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease
    Rachele Ciccocioppo
    Clinica Medica I, Fondazione IRCCS Policlinico San Matteo, Universita degli Studi di Pavia, Pavia, Italy
    Gut 60:788-98. 2011
    ..We therefore investigated the feasibility, safety and efficacy of serial intrafistular injections of autologous bone marrow-derived mesenchymal stromal cells (MSCs) in the treatment of fistulising Crohn's disease...
  16. doi request reprint Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference
    Franco Locatelli
    Pediatric Hematology Oncology, University of Pavia, IRCCS Foundation, Policlinico San Matteo, Pavia, Italy
    Clin Immunol 133:171-8. 2009
    ..In view of the favorable clinical outcome of children with chemo-resistant ALL, Haplo HSCT from an NK-alloreactive relative could become a first option in these high-risk leukemia patients...
  17. doi request reprint T-cell lines specific for peptides of adenovirus hexon protein and devoid of alloreactivity against recipient cells can be obtained from HLA-haploidentical donors
    Patrizia Comoli
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    J Immunother 31:529-36. 2008
    ..These T cells may be safely employed for adoptive treatment of HAdV complications...
  18. doi request reprint Feasibility and safety of adoptive immunotherapy with ex vivo-generated autologous, cytotoxic T lymphocytes in patients with solid tumor
    Daniela Montagna
    Dipartimento di Scienze Pediatriche, Universita di Pavia, Italy
    Cytotherapy 14:80-90. 2012
    ..Anti-tumor CTL, proven to be reactive in vitro against patient tumor cells, but not against normal cells, were infused following lymphodepleting chemotherapy administered to favor T-cell proliferation in vivo...
  19. ncbi request reprint Ex vivo generation and expansion of anti-tumor cytotoxic T-cell lines derived from patients or their HLA-identical sibling
    Daniela Montagna
    Immunology Laboratory and Pediatric Hematology Oncology, IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi, 27100 Pavia, Italy
    Int J Cancer 110:76-86. 2004
    ..Altogether these results demonstrate that our experimental approach is suitable for efficiently generating and expanding anti-solid tumor CTL to be used for adoptive immunotherapy...
  20. ncbi request reprint Innovative approaches of adoptive immune cell therapy in paediatric recipients of haematopoietic stem cell transplantation
    Franco Locatelli
    Paediatric Haematology and Oncology, IRCCS Policlinico San Matteo, P le Golgi, 2, 27100 Pavia, Italy
    Best Pract Res Clin Haematol 17:479-92. 2004
    ..In this regard, strategies of ex-vivo generation and expansion of clones or cell lines, specifically or preferentially leukaemia reactive, have been developed...
  21. ncbi request reprint Prospective simultaneous quantification of human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in young recipients of allogeneic hematopoietic stem cell transplants
    Daniele Lilleri
    Servizio di Virologia, Instituto di Ricovero e Cura a Carattere Scientifico San Matteo, 27100 Pavia, Italy
    Blood 108:1406-12. 2006
    ....
  22. ncbi request reprint T lymphocytes of recipient origin may contribute to the recovery of specific immune response toward viruses and fungi in children undergoing cord blood transplantation
    Daniela Montagna
    Dipartimento di Scienze Pediatriche, Università Pavia, IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100 Pavia, Italy
    Blood 103:4322-9. 2004
    ..Our results document, at a clonal level, that after CBT recovery of either polyclonal or pauciclonal T-cell response toward widespread pathogens is prompt, with some patients benefiting from a contribution of recipient-derived cells...
  23. ncbi request reprint Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Cancer Res 67:9142-9. 2007
    ..ALT was not evidenced in the MSCs tested. BM-derived MSCs can be safely expanded in vitro and are not susceptible to malignant transformation, thus rendering these cells suitable for cell therapy approaches...
  24. ncbi request reprint B lymphocyte reconstitution after hematopoietic stem cell transplantation: functional immaturity and slow recovery of memory CD27+ B cells
    Maria Antonietta Avanzini
    Laboratorio di Immunologia dei Trapianti e Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, University of Pavia, Pavia, Italy
    Exp Hematol 33:480-6. 2005
    ..HSCT recipients may obtain protective titers of pathogen-specific antibody through vaccination, but optimal timing of reimmunization remains to be defined...
  25. ncbi request reprint Dendritic cells pulsed with polyomavirus BK antigen induce ex vivo polyoma BK virus-specific cytotoxic T-cell lines in seropositive healthy individuals and renal transplant recipients
    Patrizia Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico S Matteo, Pavia, Italy
    J Am Soc Nephrol 14:3197-204. 2003
    ..Application of this culture system may allow a preemptive therapy approach to BKV-related complications in transplant recipients, based on CTL treatment guided by BKV DNA levels...
  26. ncbi request reprint Generation and ex vivo expansion of cytotoxic T lymphocytes directed toward different types of leukemia or myelodysplastic cells using both HLA-matched and partially matched donors
    Daniela Montagna
    Oncoematologia Pediatrica, Laboratorio d Immunologia dei Trapianti, Universita di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Exp Hematol 31:1031-8. 2003
    ..In this study, we evaluated the possibility of generating and expanding in vitro CTL directed toward different types of either leukemia or myelodysplastic cells, using both HLA-matched and partially matched donors...
  27. ncbi request reprint Single-cell cloning of human, donor-derived antileukemia T-cell lines for in vitro separation of graft-versus-leukemia effect from graft-versus-host reaction
    Daniela Montagna
    Department of Pediatrics, Laboratory of Immunology, University of Pavia, Italy
    Cancer Res 66:7310-6. 2006
    ....
  28. doi request reprint Immunotherapy against EBV-lymphoma in recipients of HSCT
    Patrizia Comoli
    Fondazione IRCCS Policlinico S Matteo, Viale Golgi 19, 27100 Pavia, Italy
    Expert Rev Hematol 3:625-32. 2010
    ....
  29. ncbi request reprint Inherited perforin and Fas mutations in a patient with autoimmune lymphoproliferative syndrome and lymphoma
    Rita Clementi
    Department of Biology and Medical Genetics, University of Pavia, Pavia, Italy
    N Engl J Med 351:1419-24. 2004
    ..The combined effect of the two mutant genes may have contributed to the development of the autoimmune lymphoproliferative syndrome and lymphoma in this patient...
  30. ncbi request reprint Infusion of autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for prevention of EBV-related lymphoproliferative disorder in solid organ transplant recipients with evidence of active virus replication
    Patrizia Comoli
    Department of Pediatrics, Immunology Laboratory, IRCCS Policlinico S Matteo, P le Golgi 2, 27100 Pavia, Italy
    Blood 99:2592-8. 2002
    ..This approach may, therefore, be safely used as prophylaxis of EBV-related lymphoproliferative disorders in these patients, following a strategy of preemptive therapy guided by EBV DNA levels...
  31. ncbi request reprint Bone marrow-resident memory T cells survive pretransplant chemotherapy and contribute to early immune reconstitution of patients with acute myeloid leukemia given mafosfamide-purged autologous bone marrow transplantation
    Giulia Casorati
    Experimental Immunology Unit, Cancer Immunotherapy and Gene Therapy Program, DIBIT, H San Raffaele Scientific Institute, Milan, Italy
    Exp Hematol 33:212-8. 2005
    ..A critical question is whether memory T cells resident in bone marrow (BM) of patients with hematological malignancies are resistant to either pretransplant chemotherapy or ex vivo pharmacological purging...
  32. ncbi request reprint Evaluation of infectious complications and immune recovery following high-dose chemotherapy (HDC) and autologous peripheral blood progenitor cell transplantation (PBPC-T) in 148 breast cancer patients
    Alberto Zambelli
    Area Omogenea Oncologica, Divisione di Oncologia Medica, Fondazione Salvatore Maugeri, Clinica del Lavoro e della Riabilitazione IRCCS, Istituto Scientifico di Pavia, Italy
    Anticancer Res 22:3701-8. 2002
    ..High-dose chemotherapy (HDC) with autologous PBPC-T has been reported to be effective in hematological and in selected solid malignancies. In this setting, infectious complications represent a relevant cause of morbidity...
  33. ncbi request reprint Retransplantation after kidney graft loss due to polyoma BK virus nephropathy: successful outcome without original allograft nephrectomy
    Fabrizio Ginevri
    Pediatric Nephrology Unit, G Gaslini Institute, Genova, Italy
    Am J Kidney Dis 42:821-5. 2003
    ..Our report indicates that an original allograft nephrectomy may not be mandatory for successful retransplantation after graft loss caused by BKV nephropathy...
  34. ncbi request reprint Cord blood transplantation provides better reconstitution of hematopoietic reservoir compared with bone marrow transplantation
    Francesco Frassoni
    Centro Cellule Staminali e Terapia Cellulare, Dipartimento Emato Oncologia, Ospedale San Martino, 16132 Genova, Italy
    Blood 102:1138-41. 2003
    ....
  35. ncbi request reprint Human mesenchymal stem cells and cyclosporin a exert a synergistic suppressive effect on in vitro activation of alloantigen-specific cytotoxic lymphocytes
    Rita Maccario
    Biol Blood Marrow Transplant 11:1031-2. 2005
  36. ncbi request reprint Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors
    Sebastian Giebel
    Department of Haematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland
    Blood 102:814-9. 2003
    ..These data indicate that natural killer (NK) cell alloreactivity is associated with better outcome after URD-HSC transplantation when ATG is used as part of GVHD prophylaxis...
  37. ncbi request reprint Mesenchymal stromal cells, from indifferent spectators to principal actors. Are we going to witness a revolution in the scenario of allograft and immune-mediated disorders?
    Franco Locatelli
    Haematologica 92:872-7. 2007
  38. ncbi request reprint Reconstitution dynamics of plasmacytoid and myeloid dendritic cell precursors after allogeneic myeloablative hematopoietic stem cell transplantation
    Francesco F Fagnoni
    Dipartimento di Oncologia, Fondazione S Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico Clinica del Lavoro e della Riabilitazione, Istituto Scientifico di Pavia, Italy
    Blood 104:281-9. 2004
    ....
  39. ncbi request reprint A proportion of patients with lymphoma may harbor mutations of the perforin gene
    Rita Clementi
    University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy
    Blood 105:4424-8. 2005
    ..These findings suggest that perforin also plays a key role in the mechanisms of immune surveillance that prevent tumor growth and/or development...
  40. ncbi request reprint Donor multipotent mesenchymal stromal cells may engraft in pediatric patients given either cord blood or bone marrow transplantation
    Sara Pozzi
    Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, Genova, Italy
    Exp Hematol 34:934-42. 2006
    ..The aim of this study was to analyze the donor/recipient origin of MSCs in children receiving allogeneic either BM or cord blood (CB) transplantation...
  41. ncbi request reprint Clinical features, long-term follow-up and outcome of a large cohort of patients with Chronic Granulomatous Disease: an Italian multicenter study
    Baldassarre Martire
    Dipartimento di Biomedicina dell Eta Evolutiva, Universita di Bari, Italy
    Clin Immunol 126:155-64. 2008
    ..No evidence justifying long-term prophylaxis with IFNgamma was obtained...
  42. ncbi request reprint Familial haemophagocytic lymphohistiocytosis: survival of a premature twin with immuno-chemotherapy and bone marrow transplantation from an HLA-identical unrelated donor
    Simone Rugolotto
    Neonatal Intensive Care Unit, Clinica Pediatrica, University of Verona, Via delle Menegone, 37134 Verona, Italy
    Acta Paediatr 94:971-4. 2005
    ..At 6 mo of age, a bone marrow transplant from an HLA-identical, unrelated volunteer was performed. Now at 32 mo of age, the infant is healthy and without signs of graft-versus-host disease...
  43. ncbi request reprint Haemophagocytic lymphohistiocytosis: proposal of a diagnostic algorithm based on perforin expression
    Maurizio Arico
    Onco Ematologia Pediatrica, Ospedale dei Bambini G Di Cristina, Palermo, Italy
    Br J Haematol 119:180-8. 2002
    ..Our flow chart could also lead to better selection of patients for specific gene analysis...
  44. doi request reprint Interleukin-15 favors the expansion of central memory CD8+ T cells in ex vivo generated, antileukemia human cytotoxic T lymphocyte lines
    Liane Daudt
    Laboratorio d Immunologia dei Trapianti e Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Brazil
    J Immunother 31:385-93. 2008
    ....