G Lupattelli

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. doi request reprint Cholesterol metabolism differs after statin therapy according to the type of hyperlipemia
    Graziana Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Life Sci 90:846-50. 2012
  2. doi request reprint A silent mutation of Niemann-Pick C1-like 1 and apolipoprotein E4 modulate cholesterol absorption in primary hyperlipidemias
    Graziana Lupattelli
    Department of Clinical and Experimental Medicine, Internal Medicine, Angiology and Atherosclerosis, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy
    J Clin Lipidol 7:147-52. 2013
  3. doi request reprint Non-cholesterol sterols in different forms of primary hyperlipemias
    G Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Nutr Metab Cardiovasc Dis 22:231-6. 2012
  4. doi request reprint Visceral fat positively correlates with cholesterol synthesis in dyslipidaemic patients
    Graziana Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Eur J Clin Invest 42:164-70. 2012
  5. doi request reprint Case report. Hyperlipoproteinaemia(a): which is the optimal therapy? A case report
    G Lupattelli
    Unit of Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, S Maria della Misericordia Hospital, Perugia, Italy
    J Clin Pharm Ther 35:613-5. 2010
  6. ncbi request reprint Increased postprandial lipemia in patients with normolipemic peripheral arterial disease
    Graziana Lupattelli
    Internal Medicine, Angiology, and Atherosclerosis Unit, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Am Heart J 143:733-8. 2002
  7. ncbi request reprint Endothelial dysfunction in vivo is related to monocyte resistin mRNA expression
    G Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Clin Pharm Ther 32:373-9. 2007
  8. doi request reprint Patterns of cholesterol metabolism: pathophysiological and therapeutic implications for dyslipidemias and the metabolic syndrome
    G Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Nutr Metab Cardiovasc Dis 21:620-7. 2011
  9. ncbi request reprint Natriuretic peptides levels are related to HDL-cholesterol with no influence on endothelium dependent vasodilatation
    G Lupattelli
    Internal Medicine Angiology and Atherosclerosis Disease, University of Perugia, Italy
    Vasa 35:215-20. 2006
  10. ncbi request reprint Artichoke juice improves endothelial function in hyperlipemia
    Graziana Lupattelli
    Section of Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Life Sci 76:775-82. 2004

Collaborators

Detail Information

Publications47

  1. doi request reprint Cholesterol metabolism differs after statin therapy according to the type of hyperlipemia
    Graziana Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Life Sci 90:846-50. 2012
    ..Common hyperlipemias have shown different patterns of cholesterol metabolism. We evaluated whether cholesterol absorption and synthesis may differ after statin therapy in primary hyperlipemias...
  2. doi request reprint A silent mutation of Niemann-Pick C1-like 1 and apolipoprotein E4 modulate cholesterol absorption in primary hyperlipidemias
    Graziana Lupattelli
    Department of Clinical and Experimental Medicine, Internal Medicine, Angiology and Atherosclerosis, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy
    J Clin Lipidol 7:147-52. 2013
    ..816C > G (L272) of Niemann-Pick C1-like 1 (NPC1L1) and of apolipoprotein (APO) E alleles on cholesterol absorption markers, sitosterol and campesterol, in 87 patients with primary hyperlipidemias...
  3. doi request reprint Non-cholesterol sterols in different forms of primary hyperlipemias
    G Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Nutr Metab Cardiovasc Dis 22:231-6. 2012
    ..We investigated the behaviour of non-cholesterol sterols, surrogate markers of cholesterol absorption (campesterol and sitosterol) and synthesis (lathosterol), in primary hyperlipemias...
  4. doi request reprint Visceral fat positively correlates with cholesterol synthesis in dyslipidaemic patients
    Graziana Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Eur J Clin Invest 42:164-70. 2012
    ....
  5. doi request reprint Case report. Hyperlipoproteinaemia(a): which is the optimal therapy? A case report
    G Lupattelli
    Unit of Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, S Maria della Misericordia Hospital, Perugia, Italy
    J Clin Pharm Ther 35:613-5. 2010
    ..Niacin was started after recurrence. One year ago, after another episode of acute coronary syndrome, rosuvastatin was added to niacin. The atherogenicity of this lipid disorder, along with the different options for therapy is discussed...
  6. ncbi request reprint Increased postprandial lipemia in patients with normolipemic peripheral arterial disease
    Graziana Lupattelli
    Internal Medicine, Angiology, and Atherosclerosis Unit, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Am Heart J 143:733-8. 2002
    ....
  7. ncbi request reprint Endothelial dysfunction in vivo is related to monocyte resistin mRNA expression
    G Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Clin Pharm Ther 32:373-9. 2007
    ..In humans, the role of resistin on metabolic and vascular homeostasis is not well defined. The aim of this study was to investigate the possible association between resistin expression and insulin resistance...
  8. doi request reprint Patterns of cholesterol metabolism: pathophysiological and therapeutic implications for dyslipidemias and the metabolic syndrome
    G Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Nutr Metab Cardiovasc Dis 21:620-7. 2011
    ....
  9. ncbi request reprint Natriuretic peptides levels are related to HDL-cholesterol with no influence on endothelium dependent vasodilatation
    G Lupattelli
    Internal Medicine Angiology and Atherosclerosis Disease, University of Perugia, Italy
    Vasa 35:215-20. 2006
    ..Aim of the study was to evaluate the behaviour of BNP and CNP in hyperlipemia and the potential relationship to FMV...
  10. ncbi request reprint Artichoke juice improves endothelial function in hyperlipemia
    Graziana Lupattelli
    Section of Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Life Sci 76:775-82. 2004
    ..66 and r=-0.62; both p <0.05). In conclusion, artichoke dietary supplementation seems to positively modulate endothelial function in hypercholesterolemia...
  11. ncbi request reprint Impaired flow-mediated vasoactivity during post-prandial phase in young healthy men
    S Marchesi
    Sezione di Medicina Interna, Angiologia e Malattie da Arteriosclerosi, University of Perugia, Policlinico Monteluce, Italy
    Atherosclerosis 153:397-402. 2000
    ..These data provide support for a role of post-prandial phase in vascular regulation in young healthy subjects...
  12. ncbi request reprint Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia: association with small, dense LDL cholesterol particles
    G Lupattelli
    Section of Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Perugia, Italy
    Am Heart J 140:521-6. 2000
    ....
  13. ncbi request reprint Direct association between high-density lipoprotein cholesterol and endothelial function in hyperlipemia
    Graziana Lupattelli
    Unit of Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Am J Cardiol 90:648-50. 2002
  14. ncbi request reprint Effects of fenofibrate on endothelial function and cell adhesion molecules during post-prandial lipemia in hypertriglyceridemia
    S Marchesi
    Unit of Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Perugia, Italy
    J Clin Pharm Ther 28:419-24. 2003
    ..Fasting and post-prandial hypertriglyceridemia have been associated with endothelial dysfunction...
  15. ncbi request reprint Oral L-arginine administration attenuates postprandial endothelial dysfunction in young healthy males
    S Marchesi
    Department of Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Italy
    J Clin Pharm Ther 26:343-9. 2001
    ..This phenomenon may be explained by the oxidative burden induced by triglyceride-rich lipoproteins, reducing nitric oxide bioavailability...
  16. ncbi request reprint Fat distribution and endothelial function in normal-overweight menopausal women
    S Marchesi
    Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Perugia, Italy
    J Clin Pharm Ther 32:477-82. 2007
    ..The development of ultrasound methodologies enable better estimation of fat distribution and more detailed investigation of the metabolic aspects of the fat depots and their impact on the initial stages of atherosclerosis...
  17. ncbi request reprint Postprandial lipemia and associated metabolic disturbances in healthy and hyperlipemic postmenopausal women
    M Pirro
    Unit of Internal Medicine, Angiology and Arteriosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Metabolism 50:330-4. 2001
    ..The presence of the features of insulin resistance syndrome could contribute to the deterioration of postprandial lipemic response in these subjects...
  18. ncbi request reprint Postprandial endothelial impairment and reduced glutathione levels in postmenopausal women
    D Siepi
    Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Via Brunacci Brunamonti 2, I 06122 Perugia, Italy
    Ann Nutr Metab 46:32-7. 2002
    ..The aim of the study was to clarify the vascular effects of postprandial state in postmenopausal women...
  19. ncbi request reprint High-density lipoprotein cholesterol and left ventricular hypertrophy in essential hypertension
    G Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Hypertens 19:2265-70. 2001
    ..This study examines the possible relation between blood lipids and LV mass in hypertension...
  20. ncbi request reprint Hyperhomocyst(e)inemia is associated with carotid atherosclerosis
    G Lupattelli
    Internal Medicine, Angiology, and Atherosclerosis Unit, University of Perugia, Italy
    Angiology 50:823-30. 1999
    ..15) and H(e) levels (x1 micromol/L, OR 1.11). This study confirmed homocyst(e)ine is associated with carotid atherosclerosis. Consequently the authors recommend H(e) levels be screened in all patients at risk for atherosclerosis...
  21. doi request reprint Effects of a phytosterol-enriched dairy product on lipids, sterols and 8-isoprostane in hypercholesterolemic patients: a multicenter Italian study
    E Mannarino
    Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Universita di Perugia, Perugia, Italy
    Nutr Metab Cardiovasc Dis 19:84-90. 2009
    ....
  22. ncbi request reprint Optimizing assessment of carotid and femoral intima-media thickness in essential hypertension
    G Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Pergia, Italy
    Am J Hypertens 14:1025-31. 2001
    ..The average of several readings in each segment, including right and left side and far and near wall, carries the closest association to left ventricular mass, and should be preferred for clinical purposes in hypertensive subjects...
  23. ncbi request reprint Mechanisms of high-density lipoprotein cholesterol effects on the endothelial function in hyperlipemia
    Graziana Lupattelli
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Metabolism 52:1191-5. 2003
    ..05). Our data suggest that in hyperlipemic subjects free of cardiovascular disease low HDL-c negatively modulates endothelial function through a lack of oxidation inhibition and a concomitant overexpression of adhesion molecules...
  24. doi request reprint Lifestyle intervention improves microvascular reactivity and increases serum adiponectin in overweight hypertensive patients
    L Pasqualini
    Department of Clinical and Experimental Medicine, University of Perugia School of Medicine, Hospital Santa Maria della Misericordia, Perugia, Italy
    Nutr Metab Cardiovasc Dis 20:87-92. 2010
    ..Obesity and hypoadiponectinemia are often associated with high blood pressure. Moreover, microvascular dysfunction is reported to be an early event in patients with hypertension and may be involved in the pathogenesis of organ damage...
  25. ncbi request reprint Early vascular damage in primary hypoalphalipoproteinemia
    Gaetano Vaudo
    Department of Internal Medicine, Angiology, and Atherosclerosis, University of Perugia, Perugia, Italy
    Metabolism 52:328-32. 2003
    ..45 and -0.49, respectively; both P <.05). In conclusion, subjects with primary hypoalpha, without overt cardiovascular disease, are characterized by an impaired endothelial function and by an increase in large-artery IMT...
  26. ncbi request reprint Low-density lipoprotein size in primary hypothyroidism. Effects of hormone replacement therapy
    A R Roscini
    Internal Medicine Angiology and Atherosclerosis Unit, University of Perugia, Italy
    Ann Nutr Metab 43:374-9. 1999
    ....
  27. ncbi request reprint Acute inflammatory state during influenza infection and endothelial function
    Simona Marchesi
    Internal Medicine Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Atherosclerosis 178:345-50. 2005
    ..65, p<0.05) and between CRP and brachial FMV (r=-0.64, p<0.05). This small study suggested that inflammatory state determined by viral agents may transitorily alter endothelial function in healthy subjects...
  28. ncbi request reprint Statin induced myopathy does not show up in MIBI scintigraphy
    G Lupattelli
    Institute of Internal Medicine, University of Perugia, Italy
    Nucl Med Commun 22:575-8. 2001
    ..These findings indicate that MIBI scintigraphy is of no help for diagnosis and gaining further insight into statin induced myopathy...
  29. ncbi request reprint Clopidogrel: hemorheological effects in subjects with subclinical atherosclerosis
    G Ciuffetti
    Internal Medicine, Angiology and Arteriosclerosis Diseases Department, University of Perugia, Italy
    Clin Hemorheol Microcirc 25:31-9. 2001
    ....
  30. ncbi request reprint Relevance of homocysteine on brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness in patients with hypercholesterolemia
    Gaetano Vaudo
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia School of Medicine, Via Brunamonti 51, 06122 Perugia, Italy
    Am J Cardiol 93:1413-6, A9. 2004
    ..Homocysteine levels seem to be an additional factor in the initial atherosclerotic damage of patients with hypercholesterolemia...
  31. doi request reprint The use of osteopathic manipulative treatment as adjuvant therapy in patients with peripheral arterial disease
    Rita Lombardini
    Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Italy
    Man Ther 14:439-43. 2009
    ..This novel treatment combined with drug and lifestyle modification might be an effective alternative to traditional training based on exercise...
  32. ncbi request reprint Human endothelial impairment in sepsis
    Gaetano Vaudo
    Internal Medicine, Angiology and Atherosclerosis University of Perugia, S Maria della Misericordia Hospital Piazzale Menghini, 1, 06129 Perugia, Italy
    Atherosclerosis 197:747-52. 2008
    ....
  33. ncbi request reprint Correlation of lipoprotein(a) levels and myocardial stress thallium scintigraphy pattern in different entities of CHD severity
    Barbara Palumbo
    Department of Radiological Sciences, University of Perugia, Monteluce University Hospital, Via Brunamonti, I 06124 Perugia, Italy
    Wien Klin Wochenschr 114:987-91. 2002
    ..The study was performed to investigate the relationship of Lp(a) and APO-E with the functional status of coronary arteries as evaluated by myocardial scintigraphy...
  34. ncbi request reprint Metabolic syndrome and preclinical atherosclerosis: focus on femoral arteries
    Gaetano Vaudo
    Internal Medicine, Angiology and Atherosclerosis, University of Perugia School of Medicine, S Maria della Misericordia Hospital, Piazzale Menghini, 1, 06100, Italy
    Metabolism 56:541-6. 2007
    ..Moreover, it focused on the strong influence of metabolic syndrome on preclinical atherosclerotic lesions at the femoral site...
  35. ncbi request reprint Racial difference in endothelial function: role of the infective burden
    Simona Marchesi
    Internal Medicine Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Atherosclerosis 191:227-34. 2007
    ..49, -0.19, -0.54, all p<0.05). This study confirms that endothelial reactivity is impaired in young African black patients; moreover its behavior is strictly related to the inflammatory state and to the total infectious burden...
  36. ncbi request reprint Effect of body weight changes on 24-hour blood pressure and left ventricular mass in hypertension: a 4-year follow-up
    Giuseppe Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Via Brunamonti 51, 06122 Perugia, Italy
    Am J Hypertens 16:634-9. 2003
    ..Few data are available on the long-term effects of weight loss on 24-h blood pressure (BP) and left ventricular mass in overweight hypertensive patients...
  37. ncbi request reprint Usefulness of brain natriuretic peptide levels to discriminate patients with stable angina pectoris without and with electrocardiographic myocardial ischemia and patients with healed myocardial infarction
    Barbara Palumbo
    Department of Radiological Science, Section of Nuclear Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti, 06124 Perugia, Italy
    Am J Cardiol 94:780-3. 2004
    ..BNP concentration was correlated positively (r = 0.923, p <0.001) with perfusion defect extent and inversely (r = -0.690, p <0.001) with the left ventricle ejection fraction (not different in the subjects examined)...
  38. ncbi request reprint Prostaglandin E1 improves endothelial function in critical limb ischemia
    Simona Marchesi
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia Medical School, Via Brunacci Brunamonti, 51 IT 06122 Perugia, Italy
    J Cardiovasc Pharmacol 41:249-53. 2003
    ..0 +/- 1.1% to 3.1 +/- 0.6% and 5.2 +/- 2.1%, both p < 0.05). In conclusion, treatment with PGE1 determines a significant improvement in endothelial function in patients with critical limb ischemia...
  39. ncbi request reprint Simvastatin increases bone mineral density in hypercholesterolemic postmenopausal women
    Graziana Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of, Perugia, Italy
    Metabolism 53:744-8. 2004
    ..860 +/- 0.110 v 0.853 +/- 0.096 and 0.847 +/- 0.095; P <.05). In conclusion, as partly suggested by retrospective or observational data, this longitudinal study indicates that simvastatin treatment exerts a beneficial effect on BMD...
  40. doi request reprint Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin
    Donatella Siepi
    Unit of Internal Medicine, Angiology and Atherosclerosis, Ospedale S Maria della Misericordia University of Perugia, Piazzale Menghini, 1 06129 Perugia, Italy
    Metabolism 57:321-5. 2008
    ..On this basis, we could speculate that OPG levels may be considered not a cardiovascular risk condition but a defense against atherosclerotic progression...
  41. ncbi request reprint Prognostic value of treatment-induced changes in twenty-four-hour mean and pulse pressures in adult hypertensive patients
    Giuseppe Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Perugia, Italy
    Am J Cardiol 90:896-9. 2002
  42. ncbi request reprint Plasma C-reactive protein in subjects with hypo/hyperalphalipoproteinemias
    Matteo Pirro
    Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Metabolism 52:432-6. 2003
    ..In conclusion, in subjects with Hypo-A or Hyper-A, HDL-C levels may account for plasma CRP variations independent of other potential cardiovascular risk factors...
  43. ncbi request reprint The endocrine function of adipose tissue: an update
    Tiziana Ronti
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Clin Endocrinol (Oxf) 64:355-65. 2006
    ..In-depth understanding of the pathophysiology and molecular actions of adipokines may, in the coming years, lead to effective therapeutic strategies designed to protect against atherosclerosis in obese patients...
  44. ncbi request reprint Combined monogenic hypercholesterolemia and hypoalphalipoproteinemia caused by mutations in LDL-R and LCAT genes
    Livia Pisciotta
    Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, I 16132 Genoa, Italy
    Atherosclerosis 182:153-9. 2005
    ..Despite the unfavourable lipoprotein profile, the proband had only mild clinical signs of atherosclerosis. This unexpected finding is probably due to the intensive lipid lowering treatment the patient has been on over the last decade...
  45. doi request reprint Non-pharmacological control of plasma cholesterol levels
    Andrea Poli
    Nutrition Foundation of Italy, Italy
    Nutr Metab Cardiovasc Dis 18:S1-16. 2008
    ..This Consensus document summarizes the view of the panel on this topic, with the aim to provide an updated support to clinicians and other health professionals involved in cardiovascular prevention...
  46. ncbi request reprint The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families
    Laura Calabresi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, 20133 Milan, Italy
    Arterioscler Thromb Vasc Biol 25:1972-8. 2005
    ..To better understand the role of lecithin:cholesterol acyltransferase (LCAT) in lipoprotein metabolism through the genetic and biochemical characterization of families carrying mutations in the LCAT gene...
  47. ncbi request reprint Assessment of brachial artery flow-mediated vasodilatation: comment on the article by Van Doornum et al
    Simona Marchesi
    Arthritis Rheum 48:2700; author reply 2700. 2003