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Species | Maurizio LuisettiSummaryAffiliation: University of Pavia Country: Italy Publications
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Publications
Perspectives for improving the evaluation and access of therapies for rare lung diseases in EuropeMaurizio Luisetti
Department of Molecular Medicine, Section of Pneumology, University of Pavia, IRCCS San Matteo Hospital Foundation, Pavia, Italy
Respir Med 106:759-68. 2012....
Circulating alpha1-antitrypsin in the general population: determinants and association with lung functionOliver Senn
Molecular Epidemiology Cancer Registry, Institutes of Social and Preventive Medicine and Clinical Pathology, University of Zurich, Zurich, Switzerland
Respir Res 9:35. 2008..Less is known about the respiratory health impact of variation in AAT serum concentrations in the general population. We cross-sectionally investigated correlates of circulating AAT concentrations and its association with FEV1...- Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiencyJan Stolk
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
Respir Res 6:47. 2005..Cross-sectional studies have shown increased levels of biomarkers of extracellular matrix degradation in vivo. Longitudinal variability of these biomarkers is unknown but desirable for clinical studies with proteinase inhibitors... - In Lysinuric Protein Intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophagesAmelia Barilli
Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Universita degli Studi di Parma, Parma, Italy
Orphanet J Rare Dis 5:32. 2010..A comparison with mesenchymal cells from the same subject has been also performed... - Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility reportSabri Denden
Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, AV Avicienne 1, 5019 Monastir, Tunisia
Orphanet J Rare Dis 4:12. 2009..We therefore planned a screening study for detection of AATD in patients with OLD in a cohort of patients from Kairouan in central Tunisia... - Alpha1-antitrypsin deficiency. 1: epidemiology of alpha1-antitrypsin deficiencyM Luisetti
Laboratorio di Biochimica e Genetica, Clinica Malattie Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
Thorax 59:164-9. 2004..The protein and molecular characteristics of variants of the alpha1-antitrypsin (AAT) gene are described, and available data on the genetic epidemiology of AAT deficiency are presented... - Desmosine as a biomarker of elastin degradation in COPD: current status and future directionsM Luisetti
Laboratory of Biochemistry and Genetics, Institute of Respiratory Disease, IRCCS San Matteo Hospital Foundation, Pavia, Italy
Eur Respir J 32:1146-57. 2008.... 
Alpha1-antitrypsin deficiency: a report from the 2nd meeting of the Alpha One International Registry, Rapallo (Genoa, Italy), 2001M Luisetti
Dept of Respiratory Diseases, IRCCS San Matteo, Pavia, Italy
Eur Respir J 20:1050-6. 2002..In the framework of a rare and often under-recognised condition, this meeting is likely to be central to improving understanding and increasing awareness of alpha1-antitrypsin deficiency...- Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizerMaurizio Luisetti
Laboratory of Biochemistry and Genetics, Respiratory Disease Unit, IRCCS San Matteo Hospital Foundation and University of Pavia, Italy
Pulm Pharmacol Ther 24:123-7. 2011..5%, similar to values for rGM-CSF prior to aerosolisation. We conclude that the highly efficient AKITA² APIXNEB® nebulizer system is likely to efficaciously deliver rGM-CSF to the airways of patients with autoimmune PAP... - Plasmapheresis for treatment of pulmonary alveolar proteinosisM Luisetti
Clinica Malattie Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
Eur Respir J 33:1220-2. 2009.... - The problems of clinical trials and registries in rare diseasesMaurizio Luisetti
Clinica di Malattie dell Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Via Golgi 19, 27100 Pavia, Italy
Respir Med 104:S42-4. 2010.... - Therapy options in pulmonary alveolar proteinosisMaurizio Luisetti
SC Pneumologia, Fondazione IRCCS, Policlinico San Matteo, Piazza Golgi 1, 27100 Pavia, Italy
Ther Adv Respir Dis 4:239-48. 2010..The aim of this paper is to provide an updated review of the current therapeutic approach to proteinosis... - Expression of receptor for advanced glycation end products in sarcoid granulomasIlaria Campo
Laboratorio di Biochimica and Genetica, Clinica Malattie Apparto Respiratorio, IRCSS Policlinico San Matteo, Universita di Pavia, Via Taramelli 5, 27100 Pavia, Italy
Am J Respir Crit Care Med 175:498-506. 2007..The RAGE coding gene maps to the 6p21.32 region, close to the genes DRB1 and BTNL2, which are associated with sarcoidosis... - NOD2/CARD15 gene polymorphisms in idiopathic pulmonary fibrosisMichele Zorzetto
Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita di Pavia
Sarcoidosis Vasc Diffuse Lung Dis 22:180-5. 2005..NOD2/CARD15 is a specific pattern recognition receptor protein, whose genetic variants have been previously associated with susceptibility to Crohn's disease... - C reactive protein and alpha1-antitrypsin: relationship between levels and gene variantsStefania Ottaviani
Center for Diagnosis of Inherited AAT Deficiency, Laboratory of Biochemistry and Genetics, Institute for Respiratory Disease, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
Transl Res 157:332-8. 2011..Simultaneous determination of CRP and AAT is useful in the correct diagnosis of heterozygotes carrying intermediate AATD genotypes; their genetic influence on the CRP level is negligible... - Relationship between diffuse pulmonary fibrosis, alveolar proteinosis, and granulocyte-macrophage colony stimulating factor autoantibodiesMaurizio Luisetti
Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy
Respir Care 56:1608-10. 2011.... - Progress in the methodological strategies for the detection in real samples of desmosine and isodesmosine, two biological markers of elastin degradationSimona Viglio
Dipartimento di Biochimica A Castellani, Universita di Pavia, Italy
J Sep Sci 30:202-13. 2007..Recent applications of CE with LIF detection (CE-LIF) for investigating the content of desmosines in different fluids will also be discussed... - Laboratory diagnosis of alpha1-antitrypsin deficiencyIlaria Ferrarotti
Centro Diagnosi per il Deficit Ereditario di Alfa1 antitripsina, Clinica Malattie Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
Transl Res 150:267-74. 2007..We also describe the diagnostic flowchart for AATD detection that we have developed accordingly... - SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrationsMichele Zorzetto
Center for Diagnosis of Severe Alpha1 antitrypsin Deficiency, Laboratory of Biochemistry and Genetics, Institute for Respiratory Disease and Unit of Statistics and Biometry, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy
Clin Chem 54:1331-8. 2008..We decided to perform an exhaustive investigation of SERPINA1 gene variants in individuals from the general population with a moderately reduced serum AAT concentration, because such information is currently unavailable... - Incomplete expression of epithelial-mesenchymal transition markers in idiopathic pulmonary fibrosisPatrizia Morbini
Dipartimento di Scienze Pediatriche e Patologia Umana ed Ereditaria, Sezione di Anatomia Patologica, Universita di Pavia, Via Forlanini 16, 27100 Pavia, Italy
Pathol Res Pract 207:559-67. 2011..Although neither hyperplastic pneumocytes nor bronchial basal cells showed evidence of complete EMT, only the latter seem to be specific for UIP and might have a role in its development... - Protein expression in sputum of smokers and chronic obstructive pulmonary disease patients: a pilot study by CapLC-ESI-Q-TOFBegona Casado
Dipartimento di Biochimica A Castellani, Universita di Pavia, Italy
J Proteome Res 6:4615-23. 2007.... - Micellar electrokinetic chromatography with laser induced detection and liquid chromatography tandem mass-spectrometry-based desmosine assays in urine of patients with Chronic Obstructive Pulmonary Disease: a comparative analysisFabio Ferrari
LabAnalysis Inc, Casanova Lonati, Pavia, Italy
J Chromatogr A 1266:103-9. 2012..Nevertheless, MEKC-LIF could be an attractive alternative in routine laboratories lacking the LC-MS instrumentation and skills to run these methods... - Serum levels and genotype distribution of α1-antitrypsin in the general populationIlaria Ferrarotti
IRCCS San Matteo Hospital Foundation, University of Pavia, Piazza Golgi 1, Pavia, Italy
Thorax 67:669-74. 2012..Diagnosis, assessment of risk for developing chronic obstructive pulmonary disease (COPD), and management of replacement therapy require the availability of precise and updated ranges for protein serum levels... - Complement receptor 1 gene polymorphisms are associated with idiopathic pulmonary fibrosisMichele Zorzetto
Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, Pavia, Italy
Am J Respir Crit Care Med 168:330-4. 2003..232, 95% confidence interval = 2.198-18.419, p = 0.00023). The significant difference was found in both sexes. These findings agree with speculations on the role of the complement receptor 1 gene in idiopathic pulmonary fibrosis... - Successful whole lung lavage in pulmonary alveolar proteinosis secondary to lysinuric protein intolerance: a case reportMichele Ceruti
Clinica Malattie Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
Orphanet J Rare Dis 2:14. 2007..Among the latter, lysinuric protein intolerance (LPI) is a rare genetic disorder caused by defective transport of cationic amino acids. Whole Lung Lavage (WLL) is currently the gold standard therapy for severe cases of PAP... - A novel method for rapid genotypic identification of alpha 1-antitrypsin variantsIlaria Ferrarotti
Laboratorio di Biochimica e Genetica, Clinica di Malattie dell'Apparato Respiratorio, IRCCS Policlinico S. Matteo, Pavia, Italy
Diagn Mol Pathol 13:160-3. 2004..We found a complete agreement among our results, IEF, and genotypes obtained by standard methods. We concluded that this novel method combines efficiency, ease, swiftness, and low cost... - [AGE receptor: a novel pro-inflammatory pathway for chronic respiratory disorders?]Ilaria Campo
Clinica Malattie Apparato Respiratorio, Laboratorio di Biochimica e Genetica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia
Recenti Prog Med 99:271-8. 2008..It is hypothetised that common factors would orchestrate such events, and RAGE is one of possible such candidates. Implications connected to RAGE pathway in varying interstitial pneumonites are discussed... - Identification of a novel alpha1-antitrypsin null variant (Q0Cairo)Michele Zorzetto
Clinica Malattie Apparato Respiratorio, IRCCS Policlinico S Matteo, Pavia 27100, Italy
Diagn Mol Pathol 14:121-4. 2005..The proposed nomenclature of Q0cairo is from the birthplace of the father of first recognized subject. Serum levels and isoelectric focusing of AAT were consistent with the presence of the Null variant... - Assessment and management of pulmonary alveolar proteinosis in a reference centerIlaria Campo
Respiratory Disease Unit, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
Orphanet J Rare Dis 8:40. 2013..We conclude that patient cohorts with an ultra-rare disease, such as PAP, referred to a single reference center, can provide useful information on the natural history and clinical course of the disease... - Targeting EGFR in non-small-cell lung cancer: lessons, experiences, strategiesGiulia M Stella
Department of Hematological, Pneumological and Cardiovascular Sciences, Section of Pneumology, University and Fondazione IRCCS Policlinico, San Matteo, 27100 Pavia, Italy
Respir Med 106:173-83. 2012..Main relevance is addressed to genetic lesions activating the EGFR pathway transducers, focusing on their role as markers of targeted drug response... - Profiling the Proteome of Exhaled Breath Condensate in Healthy Smokers and COPD Patients by LC-MS/MSMarco Fumagalli
Department of Biology and Biotechnology, University of Pavia, Via Taramelli 3 B, 27100 Pavia, Italy
Int J Mol Sci 13:13894-910. 2012..These results are the prelude of quantitative studies aimed at identifying which of these proteins hold promise as identifiers of differences that could distinguish healthy subjects from patients... - The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease?Patrizia Morbini
Dipartimento di Anatomia ed Istologia Patologica, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
Mod Pathol 19:1437-45. 2006.... - Pulmonary alveolar proteinosis: diagnostic and therapeutic challengesIlaria Campo
Section of Pneumology, Department of Molecular Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Via Taramelli 5, 27100, Pavia, Italy
Multidiscip Respir Med 7:4. 2012..In this paper we review the therapeutic strategies which have been proposed for the treatment of PAP patients and the progress which has been made in the understanding of the disease pathogenesis... - Factors influencing oxidative imbalance in pulmonary fibrosis: an immunohistochemical studySimona Inghilleri
Respiratory Disease, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
Pulm Med 2011:421409. 2011..A lower degree of tissue nitrosilation was observed in UIP than in COP. Conclusions. Fibroblast lesions of UIP and of COP share a similar degree of activation of RAGE, while antioxidant enzyme expression markedly reduced in UIP... - SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastaseMarina Gorrini
Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
Respir Res 6:146. 2005..With the hypothesis that SP-A could bind alpha1-antitrypsin, we designed a series of in vitro experiments aimed at investigating the nature and consequences of such an interaction... - Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to alpha1-antitrypsin deficiencyMarco Fumagalli
Dipartimento di Biochimica A Castellani, Universita di Pavia, Italy
J Proteomics 71:211-21. 2008..These sensitive techniques allowed to identify a number of cytokines and cytokeratins. Their level was found to be higher in patients than in controls... - HLA and sarcoidosis: new pathogenetic insightsMiryam Martinetti
Servizio di Immunoematologia e Transfusione e Centro di Immunologia dei Trapianti, IRCCS Policlinico S Matteo, Pavia, Italy
Sarcoidosis Vasc Diffuse Lung Dis 19:83-95. 2002.... - Secondary outputs of alpha1-antitrypsin deficiency targeted detection programmeI Ferrarotti
Centro di Diagnosi per il Deficit Ereditario di Alfa1 Antitripsina, Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
Respir Med 102:354-8. 2008..Individuals enrolled in AATD detection programmes represent an interesting cohort both for public health and research purposes... - Micellar electrokinetic chromatographic and capillary zone electrophoretic methods for screening urinary biomarkers of human disorders: a critical review of the state-of-the-artPaolo Iadarola
Dipartimento di Biochimica A Castellani, Universita di Pavia, Pavia, Italy
Electrophoresis 26:752-66. 2005..The aim of the present article is to focus the interest of the reader on recent applications of MEKC and CZE in the field of urinary biomarkers and to discuss advantages and/or limitations of each mode... - Complement receptor 1 gene polymorphisms in sarcoidosisMichele Zorzetto
Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, Pavia, Italy
Am J Respir Cell Mol Biol 27:17-23. 2002..The same genotype was particularly associated to disease in females (OR = 7.05; 95% CI 3.10-16.61 versus healthy control subjects). These findings agree with speculations on the role of CR1 gene as a possible susceptibility factor... - Urinary desmosine excretion in acute exacerbations of COPD: a preliminary reportD Fiorenza
Laboratorio di Biochimica e Genetica della Clinica di Malattie dell'Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita degli Studi di Pavia, Italy
Respir Med 96:110-4. 2002..2 microg g(-1) creatinine or 16% of the recovery desmosine value. We conclude that there is a small but statistically significant increase in lung elastin breakdown in the body during an acute exacerbation of COPD... - A national program for detection of alpha 1-antitrypsin deficiency in Italy. Gruppo I.D.AM Luisetti
Istituto di Tisiologia e Malattie Respiratorie, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
Respir Med 93:169-72. 1999..We believe that such a program plays a crucial role in identifying AAT deficiency in a country such as Italy, with low prevalence and low awareness of this rare condition... - Micellar electrokinetic chromatography for the determination of urinary desmosine and isodesmosine in patients affected by chronic obstructive pulmonary diseaseS Viglio
Dipartimento di Biochimica A Castellani, Universita di Pavia, Italy
J Chromatogr B Biomed Sci Appl 714:87-98. 1998..Thus micellar electrokinetic chromatography (MEKC) may be considered as a reliable technique for studying the turnover of the elastic fiber in clinical conditions... - The role of desmosines as biomarkers for chronic obstructive pulmonary diseasePaolo Iadarola
Department of Biology and Biotechnologies, University of Pavia, 27100 Pavia, Italy
Expert Rev Respir Med 7:137-44. 2013..The authors conclude that desmosines, although not yet definitely proven, have nevertheless all the requisites to become a critical COPD biomarker... - The rapid FEV(1) decline in chronic obstructive pulmonary disease is associated with predominant emphysema: a longitudinal studyIsa Cerveri
Division of Respiratory Diseases, Department of Molecular Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
COPD 10:55-61. 2013..The aim of this study was to identify the clinical, functional and imaging characteristics associated with the rapid FEV(1) decline in COPD... - Long-term durable benefit after whole lung lavage in pulmonary alveolar proteinosisM Beccaria
Respiratory Diseases Division, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico S Matteo, University of Pavia, Pavia, Italy
Eur Respir J 23:526-31. 2004..In conclusion, whole lung lavage for idiopathic pulmonary alveolar proteinosis is currently a safe procedure in an experienced setting, and provides long-lasting benefits in the majority of patients... - Tumour necrosis factor family genes in a phenotype of COPD associated with emphysemaI Ferrarotti
Dept of Respiratory Diseases, IRCCS San Matteo Hospital, University of Pavia, Pavia, Italy
Eur Respir J 21:444-9. 2003..Nevertheless, the authors would like to emphasise the importance of narrowing the phenotype in the search for genetic risk factors in chronic obstructive pulmonary disease... - A fast amplification-reverse hybridization assay kit to detect the most frequent deficient variants in the alpha-1-antitrypsin geneM Zorzetto
Laboratorio di Biochimica e Genetica, Clinica di Malattie dell'Apparato Respiratorio, IRCCS Policlinico San Matteo, , Italia
Respiration 69:81-5. 2002..Because of its transferability to routine laboratories, the test kit may be useful in identifying cases of severe AATD, thus resulting in increasing awareness of this rare disorder... - "The sarcoidosis map": a joint survey of clinical and immunogenetic findings in two European countriesM Martinetti
Servizio di Immunoematologia e Transfusione, IRCCS Policlinico San Matteo, Pavia, Italy
Am J Respir Crit Care Med 152:557-64. 1995..Our results seem to support the concept that immunogenetic background may at least partly account for the clinical heterogeneity of sarcoidosis... - Prevalence and phenotype of subjects carrying rare variants in the Italian registry for alpha1-antitrypsin deficiencyI Ferrarotti
J Med Genet 42:282-7. 2005 - Ongoing research in Europe: Alpha One International Registry (AIR) objectives and developmentR A Stockley
Dept of Medicine, University Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK
Eur Respir J 29:582-6. 2007..The success related to the convergence of national registries into a common database creating a unique registry beyond geographic boundaries and encompassing alpha1-antitrypsin deficiency from various ethnic groups... - Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency allelesF J de Serres
Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
Monaldi Arch Chest Dis 63:133-41. 2005..This genetic disease is known to exist in Italy and is related to a high risk for development of jaundice in infants, liver disease in children and adults, and pulmonary emphysema in adults... - [American Thoracic Society/European Respiratory Society Statement: Standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency]J K Stoller
Pneumologie 59:36-68. 2005 - Complete mutational screening of the CFTR gene in 120 patients with pulmonary diseaseC Bombieri
Istituto di Biologia e Genetica, Universita di Verona, Italy
Hum Genet 103:718-22. 1998..These results confirm the involvement of the CFTR gene in disseminated bronchiectasis of unknown origin, and suggest a possible role for CFTR gene mutations in sarcoidosis, and for the 5T allele in pulmonary emphysema... - Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaproseE Korzus
Department of Biochemistry, University of Georgia, Athens 30602
Biol Chem Hoppe Seyler 375:335-41. 1994.... - Alpha-1 antitrypsin deficiency: from Italy to the worldB Balbi
Monaldi Arch Chest Dis 67:176-8. 2007