Maurizio Luisetti

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. pmc A large kindred of pulmonary fibrosis associated with a novel ABCA3 gene variant
    Ilaria Campo
    Pneumology Unit, IRCCS San Matteo Foundation Hospital, Piazza Golgi 1, Pavia 27100, Italy
    Respir Res 15:43. 2014
  2. pmc The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosis
    Bruce C Trapnell
    Department of Molecular Medicine, Pneumology Unit, San Matteo Hospital Foundation, University of Pavia, Piazza Golgi 1, Pavia 27100, Italy
    Orphanet J Rare Dis 8:153. 2013
  3. pmc Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
    A Rembert Koczulla
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Orphanet J Rare Dis 7:29. 2012
  4. doi request reprint Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe
    Maurizio Luisetti
    Department of Molecular Medicine, Section of Pneumology, University of Pavia, IRCCS San Matteo Hospital Foundation, Pavia, Italy
    Respir Med 106:759-68. 2012
  5. pmc Circulating alpha1-antitrypsin in the general population: determinants and association with lung function
    Oliver Senn
    Molecular Epidemiology Cancer Registry, Institutes of Social and Preventive Medicine and Clinical Pathology, University of Zurich, Zurich, Switzerland
    Respir Res 9:35. 2008
  6. pmc Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency
    Jan Stolk
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 6:47. 2005
  7. pmc In Lysinuric Protein Intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophages
    Amelia Barilli
    Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Universita degli Studi di Parma, Parma, Italy
    Orphanet J Rare Dis 5:32. 2010
  8. pmc Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report
    Sabri Denden
    Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, AV Avicienne 1, 5019 Monastir, Tunisia
    Orphanet J Rare Dis 4:12. 2009
  9. doi request reprint Desmosine as a biomarker of elastin degradation in COPD: current status and future directions
    M Luisetti
    Laboratory of Biochemistry and Genetics, Institute of Respiratory Disease, IRCCS San Matteo Hospital Foundation, Pavia, Italy
    Eur Respir J 32:1146-57. 2008
  10. ncbi request reprint Alpha1-antitrypsin deficiency: a report from the 2nd meeting of the Alpha One International Registry, Rapallo (Genoa, Italy), 2001
    M Luisetti
    Dept of Respiratory Diseases, IRCCS San Matteo, Pavia, Italy
    Eur Respir J 20:1050-6. 2002

Collaborators

Detail Information

Publications62

  1. pmc A large kindred of pulmonary fibrosis associated with a novel ABCA3 gene variant
    Ilaria Campo
    Pneumology Unit, IRCCS San Matteo Foundation Hospital, Piazza Golgi 1, Pavia 27100, Italy
    Respir Res 15:43. 2014
    ..To our knowledge, ABCA3 gene was not previously reported as causative agent of fibrosis affecting both children and adults in the same kindred...
  2. pmc The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosis
    Bruce C Trapnell
    Department of Molecular Medicine, Pneumology Unit, San Matteo Hospital Foundation, University of Pavia, Piazza Golgi 1, Pavia 27100, Italy
    Orphanet J Rare Dis 8:153. 2013
    ....
  3. pmc Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
    A Rembert Koczulla
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Orphanet J Rare Dis 7:29. 2012
    ..A study was undertaken to investigate gene expression patterns in end-stage COPD lungs from patients with and without AATD...
  4. doi request reprint Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe
    Maurizio Luisetti
    Department of Molecular Medicine, Section of Pneumology, University of Pavia, IRCCS San Matteo Hospital Foundation, Pavia, Italy
    Respir Med 106:759-68. 2012
    ....
  5. pmc Circulating alpha1-antitrypsin in the general population: determinants and association with lung function
    Oliver Senn
    Molecular Epidemiology Cancer Registry, Institutes of Social and Preventive Medicine and Clinical Pathology, University of Zurich, Zurich, Switzerland
    Respir Res 9:35. 2008
    ..Less is known about the respiratory health impact of variation in AAT serum concentrations in the general population. We cross-sectionally investigated correlates of circulating AAT concentrations and its association with FEV1...
  6. pmc Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency
    Jan Stolk
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 6:47. 2005
    ..Cross-sectional studies have shown increased levels of biomarkers of extracellular matrix degradation in vivo. Longitudinal variability of these biomarkers is unknown but desirable for clinical studies with proteinase inhibitors...
  7. pmc In Lysinuric Protein Intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophages
    Amelia Barilli
    Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Universita degli Studi di Parma, Parma, Italy
    Orphanet J Rare Dis 5:32. 2010
    ..A comparison with mesenchymal cells from the same subject has been also performed...
  8. pmc Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report
    Sabri Denden
    Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, AV Avicienne 1, 5019 Monastir, Tunisia
    Orphanet J Rare Dis 4:12. 2009
    ..We therefore planned a screening study for detection of AATD in patients with OLD in a cohort of patients from Kairouan in central Tunisia...
  9. doi request reprint Desmosine as a biomarker of elastin degradation in COPD: current status and future directions
    M Luisetti
    Laboratory of Biochemistry and Genetics, Institute of Respiratory Disease, IRCCS San Matteo Hospital Foundation, Pavia, Italy
    Eur Respir J 32:1146-57. 2008
    ....
  10. ncbi request reprint Alpha1-antitrypsin deficiency: a report from the 2nd meeting of the Alpha One International Registry, Rapallo (Genoa, Italy), 2001
    M Luisetti
    Dept of Respiratory Diseases, IRCCS San Matteo, Pavia, Italy
    Eur Respir J 20:1050-6. 2002
    ..In the framework of a rare and often under-recognised condition, this meeting is likely to be central to improving understanding and increasing awareness of alpha1-antitrypsin deficiency...
  11. doi request reprint Therapy options in pulmonary alveolar proteinosis
    Maurizio Luisetti
    SC Pneumologia, Fondazione IRCCS, Policlinico San Matteo, Piazza Golgi 1, 27100 Pavia, Italy
    Ther Adv Respir Dis 4:239-48. 2010
    ..The aim of this paper is to provide an updated review of the current therapeutic approach to proteinosis...
  12. doi request reprint The problems of clinical trials and registries in rare diseases
    Maurizio Luisetti
    Clinica di Malattie dell Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Via Golgi 19, 27100 Pavia, Italy
    Respir Med 104:S42-4. 2010
    ....
  13. pmc Alpha1-antitrypsin deficiency. 1: epidemiology of alpha1-antitrypsin deficiency
    M Luisetti
    Laboratorio di Biochimica e Genetica, Clinica Malattie Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Thorax 59:164-9. 2004
    ..The protein and molecular characteristics of variants of the alpha1-antitrypsin (AAT) gene are described, and available data on the genetic epidemiology of AAT deficiency are presented...
  14. doi request reprint Plasmapheresis for treatment of pulmonary alveolar proteinosis
    M Luisetti
    Clinica Malattie Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Eur Respir J 33:1220-2. 2009
    ....
  15. doi request reprint Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizer
    Maurizio Luisetti
    Laboratory of Biochemistry and Genetics, Respiratory Disease Unit, IRCCS San Matteo Hospital Foundation and University of Pavia, Italy
    Pulm Pharmacol Ther 24:123-7. 2011
    ..5%, similar to values for rGM-CSF prior to aerosolisation. We conclude that the highly efficient AKITA² APIXNEB® nebulizer system is likely to efficaciously deliver rGM-CSF to the airways of patients with autoimmune PAP...
  16. ncbi request reprint Expression of receptor for advanced glycation end products in sarcoid granulomas
    Ilaria Campo
    Laboratorio di Biochimica and Genetica, Clinica Malattie Apparto Respiratorio, IRCSS Policlinico San Matteo, Universita di Pavia, Via Taramelli 5, 27100 Pavia, Italy
    Am J Respir Crit Care Med 175:498-506. 2007
    ..The RAGE coding gene maps to the 6p21.32 region, close to the genes DRB1 and BTNL2, which are associated with sarcoidosis...
  17. ncbi request reprint NOD2/CARD15 gene polymorphisms in idiopathic pulmonary fibrosis
    Michele Zorzetto
    Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita di Pavia
    Sarcoidosis Vasc Diffuse Lung Dis 22:180-5. 2005
    ..NOD2/CARD15 is a specific pattern recognition receptor protein, whose genetic variants have been previously associated with susceptibility to Crohn's disease...
  18. doi request reprint Relationship between diffuse pulmonary fibrosis, alveolar proteinosis, and granulocyte-macrophage colony stimulating factor autoantibodies
    Maurizio Luisetti
    Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy
    Respir Care 56:1608-10. 2011
    ....
  19. doi request reprint C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants
    Stefania Ottaviani
    Center for Diagnosis of Inherited AAT Deficiency, Laboratory of Biochemistry and Genetics, Institute for Respiratory Disease, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
    Transl Res 157:332-8. 2011
    ..Simultaneous determination of CRP and AAT is useful in the correct diagnosis of heterozygotes carrying intermediate AATD genotypes; their genetic influence on the CRP level is negligible...
  20. pmc Assessment and management of pulmonary alveolar proteinosis in a reference center
    Ilaria Campo
    Respiratory Disease Unit, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Orphanet J Rare Dis 8:40. 2013
    ..We conclude that patient cohorts with an ultra-rare disease, such as PAP, referred to a single reference center, can provide useful information on the natural history and clinical course of the disease...
  21. ncbi request reprint Laboratory diagnosis of alpha1-antitrypsin deficiency
    Ilaria Ferrarotti
    Centro Diagnosi per il Deficit Ereditario di Alfa1 antitripsina, Clinica Malattie Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Transl Res 150:267-74. 2007
    ..We also describe the diagnostic flowchart for AATD detection that we have developed accordingly...
  22. ncbi request reprint Progress in the methodological strategies for the detection in real samples of desmosine and isodesmosine, two biological markers of elastin degradation
    Simona Viglio
    Dipartimento di Biochimica A Castellani, Universita di Pavia, Italy
    J Sep Sci 30:202-13. 2007
    ..Recent applications of CE with LIF detection (CE-LIF) for investigating the content of desmosines in different fluids will also be discussed...
  23. doi request reprint SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrations
    Michele Zorzetto
    Center for Diagnosis of Severe Alpha1 antitrypsin Deficiency, Laboratory of Biochemistry and Genetics, Institute for Respiratory Disease and Unit of Statistics and Biometry, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy
    Clin Chem 54:1331-8. 2008
    ..We decided to perform an exhaustive investigation of SERPINA1 gene variants in individuals from the general population with a moderately reduced serum AAT concentration, because such information is currently unavailable...
  24. doi request reprint Incomplete expression of epithelial-mesenchymal transition markers in idiopathic pulmonary fibrosis
    Patrizia Morbini
    Dipartimento di Scienze Pediatriche e Patologia Umana ed Ereditaria, Sezione di Anatomia Patologica, Universita di Pavia, Via Forlanini 16, 27100 Pavia, Italy
    Pathol Res Pract 207:559-67. 2011
    ..Although neither hyperplastic pneumocytes nor bronchial basal cells showed evidence of complete EMT, only the latter seem to be specific for UIP and might have a role in its development...
  25. doi request reprint EGFR and KRAS mutational profiling in fresh non-small cell lung cancer (NSCLC) cells
    Giulia M Stella
    Laboratory of Biochemistry and Genetics, Division of Pneumology, Department of Molecular Medicine, University and Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    J Cancer Res Clin Oncol 139:1327-35. 2013
    ..The latter currently represents the most appropriate diagnostic procedure in case of peripheral lesions, such as adenocarcinomas, which account for almost 40% of all NSCLCs and for the highest EGFR mutational rates...
  26. ncbi request reprint Protein expression in sputum of smokers and chronic obstructive pulmonary disease patients: a pilot study by CapLC-ESI-Q-TOF
    Begona Casado
    Dipartimento di Biochimica A Castellani, Universita di Pavia, Italy
    J Proteome Res 6:4615-23. 2007
    ....
  27. doi request reprint Micellar electrokinetic chromatography with laser induced detection and liquid chromatography tandem mass-spectrometry-based desmosine assays in urine of patients with Chronic Obstructive Pulmonary Disease: a comparative analysis
    Fabio Ferrari
    LabAnalysis Inc, Casanova Lonati, Pavia, Italy
    J Chromatogr A 1266:103-9. 2012
    ..Nevertheless, MEKC-LIF could be an attractive alternative in routine laboratories lacking the LC-MS instrumentation and skills to run these methods...
  28. doi request reprint Serum levels and genotype distribution of α1-antitrypsin in the general population
    Ilaria Ferrarotti
    IRCCS San Matteo Hospital Foundation, University of Pavia, Piazza Golgi 1, Pavia, Italy
    Thorax 67:669-74. 2012
    ..Diagnosis, assessment of risk for developing chronic obstructive pulmonary disease (COPD), and management of replacement therapy require the availability of precise and updated ranges for protein serum levels...
  29. ncbi request reprint Complement receptor 1 gene polymorphisms are associated with idiopathic pulmonary fibrosis
    Michele Zorzetto
    Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, Pavia, Italy
    Am J Respir Crit Care Med 168:330-4. 2003
    ..232, 95% confidence interval = 2.198-18.419, p = 0.00023). The significant difference was found in both sexes. These findings agree with speculations on the role of the complement receptor 1 gene in idiopathic pulmonary fibrosis...
  30. pmc Successful whole lung lavage in pulmonary alveolar proteinosis secondary to lysinuric protein intolerance: a case report
    Michele Ceruti
    Clinica Malattie Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Orphanet J Rare Dis 2:14. 2007
    ..Among the latter, lysinuric protein intolerance (LPI) is a rare genetic disorder caused by defective transport of cationic amino acids. Whole Lung Lavage (WLL) is currently the gold standard therapy for severe cases of PAP...
  31. ncbi request reprint [AGE receptor: a novel pro-inflammatory pathway for chronic respiratory disorders?]
    Ilaria Campo
    Clinica Malattie Apparato Respiratorio, Laboratorio di Biochimica e Genetica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia
    Recenti Prog Med 99:271-8. 2008
    ..It is hypothetised that common factors would orchestrate such events, and RAGE is one of possible such candidates. Implications connected to RAGE pathway in varying interstitial pneumonites are discussed...
  32. ncbi request reprint Identification of a novel alpha1-antitrypsin null variant (Q0Cairo)
    Michele Zorzetto
    Clinica Malattie Apparato Respiratorio, IRCCS Policlinico S Matteo, Pavia 27100, Italy
    Diagn Mol Pathol 14:121-4. 2005
    ..The proposed nomenclature of Q0cairo is from the birthplace of the father of first recognized subject. Serum levels and isoelectric focusing of AAT were consistent with the presence of the Null variant...
  33. ncbi request reprint A novel method for rapid genotypic identification of alpha 1-antitrypsin variants
    Ilaria Ferrarotti
    Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, IRCCS Policlinico S Matteo, Pavia, Italy
    Diagn Mol Pathol 13:160-3. 2004
    ..We found a complete agreement among our results, IEF, and genotypes obtained by standard methods. We concluded that this novel method combines efficiency, ease, swiftness, and low cost...
  34. ncbi request reprint The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease?
    Patrizia Morbini
    Dipartimento di Anatomia ed Istologia Patologica, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Mod Pathol 19:1437-45. 2006
    ....
  35. doi request reprint Targeting EGFR in non-small-cell lung cancer: lessons, experiences, strategies
    Giulia M Stella
    Department of Hematological, Pneumological and Cardiovascular Sciences, Section of Pneumology, University and Fondazione IRCCS Policlinico, San Matteo, 27100 Pavia, Italy
    Respir Med 106:173-83. 2012
    ..Main relevance is addressed to genetic lesions activating the EGFR pathway transducers, focusing on their role as markers of targeted drug response...
  36. doi request reprint From micellar electrokinetic chromatography to liquid chromatography-mass spectrometry: revisiting the way of analyzing human fluids for the search of desmosines, putative biomarkers of chronic obstructive pulmonary disease
    Simona Viglio
    Department of Molecular Medicine, Division of Biochemistry, University of Pavia, Pavia, Italy
    Electrophoresis 35:109-18. 2014
    ....
  37. doi request reprint The role of desmosines as biomarkers for chronic obstructive pulmonary disease
    Paolo Iadarola
    Department of Biology and Biotechnologies, University of Pavia, 27100 Pavia, Italy
    Expert Rev Respir Med 7:137-44. 2013
    ..The authors conclude that desmosines, although not yet definitely proven, have nevertheless all the requisites to become a critical COPD biomarker...
  38. pmc Profiling the Proteome of Exhaled Breath Condensate in Healthy Smokers and COPD Patients by LC-MS/MS
    Marco Fumagalli
    Department of Biology and Biotechnology, University of Pavia, Via Taramelli 3 B, 27100 Pavia, Italy
    Int J Mol Sci 13:13894-910. 2012
    ..These results are the prelude of quantitative studies aimed at identifying which of these proteins hold promise as identifiers of differences that could distinguish healthy subjects from patients...
  39. pmc Pulmonary alveolar proteinosis: diagnostic and therapeutic challenges
    Ilaria Campo
    Section of Pneumology, Department of Molecular Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Via Taramelli 5, 27100, Pavia, Italy
    Multidiscip Respir Med 7:4. 2012
    ..In this paper we review the therapeutic strategies which have been proposed for the treatment of PAP patients and the progress which has been made in the understanding of the disease pathogenesis...
  40. pmc Factors influencing oxidative imbalance in pulmonary fibrosis: an immunohistochemical study
    Simona Inghilleri
    Respiratory Disease, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
    Pulm Med 2011:421409. 2011
    ..A lower degree of tissue nitrosilation was observed in UIP than in COP. Conclusions. Fibroblast lesions of UIP and of COP share a similar degree of activation of RAGE, while antioxidant enzyme expression markedly reduced in UIP...
  41. pmc SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase
    Marina Gorrini
    Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Respir Res 6:146. 2005
    ..With the hypothesis that SP-A could bind alpha1-antitrypsin, we designed a series of in vitro experiments aimed at investigating the nature and consequences of such an interaction...
  42. doi request reprint Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to alpha1-antitrypsin deficiency
    Marco Fumagalli
    Dipartimento di Biochimica A Castellani, Universita di Pavia, Italy
    J Proteomics 71:211-21. 2008
    ..These sensitive techniques allowed to identify a number of cytokines and cytokeratins. Their level was found to be higher in patients than in controls...
  43. ncbi request reprint HLA and sarcoidosis: new pathogenetic insights
    Miryam Martinetti
    Servizio di Immunoematologia e Transfusione e Centro di Immunologia dei Trapianti, IRCCS Policlinico S Matteo, Pavia, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 19:83-95. 2002
    ....
  44. ncbi request reprint Secondary outputs of alpha1-antitrypsin deficiency targeted detection programme
    I Ferrarotti
    Centro di Diagnosi per il Deficit Ereditario di Alfa1 Antitripsina, Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Respir Med 102:354-8. 2008
    ..Individuals enrolled in AATD detection programmes represent an interesting cohort both for public health and research purposes...
  45. doi request reprint Oncogenes in non-small-cell lung cancer: emerging connections and novel therapeutic dynamics
    Giulia M Stella
    Department of Molecular Medicine, Division of Pneumology, Laboratory of Biochemistry and Genetics, University and Fondazione IRCCS Policlinico, San Matteo, Pavia, Italy Institute for Cancer Research at Candiolo, Candiolo, Italy Electronic address
    Lancet Respir Med 1:251-61. 2013
    ..This paradigmatic shift in tailoring therapies should effectively improve outcomes for patients. ..
  46. ncbi request reprint The rapid FEV(1) decline in chronic obstructive pulmonary disease is associated with predominant emphysema: a longitudinal study
    Isa Cerveri
    Division of Respiratory Diseases, Department of Molecular Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    COPD 10:55-61. 2013
    ..The aim of this study was to identify the clinical, functional and imaging characteristics associated with the rapid FEV(1) decline in COPD...
  47. ncbi request reprint Complement receptor 1 gene polymorphisms in sarcoidosis
    Michele Zorzetto
    Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, Pavia, Italy
    Am J Respir Cell Mol Biol 27:17-23. 2002
    ..The same genotype was particularly associated to disease in females (OR = 7.05; 95% CI 3.10-16.61 versus healthy control subjects). These findings agree with speculations on the role of CR1 gene as a possible susceptibility factor...
  48. ncbi request reprint Micellar electrokinetic chromatographic and capillary zone electrophoretic methods for screening urinary biomarkers of human disorders: a critical review of the state-of-the-art
    Paolo Iadarola
    Dipartimento di Biochimica A Castellani, Universita di Pavia, Pavia, Italy
    Electrophoresis 26:752-66. 2005
    ..The aim of the present article is to focus the interest of the reader on recent applications of MEKC and CZE in the field of urinary biomarkers and to discuss advantages and/or limitations of each mode...
  49. ncbi request reprint A national program for detection of alpha 1-antitrypsin deficiency in Italy. Gruppo I.D.A
    M Luisetti
    Istituto di Tisiologia e Malattie Respiratorie, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Respir Med 93:169-72. 1999
    ..We believe that such a program plays a crucial role in identifying AAT deficiency in a country such as Italy, with low prevalence and low awareness of this rare condition...
  50. ncbi request reprint Urinary desmosine excretion in acute exacerbations of COPD: a preliminary report
    D Fiorenza
    Laboratorio di Biochimica e Genetica della Clinica di Malattie dell Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita degli Studi di Pavia, Italy
    Respir Med 96:110-4. 2002
    ..2 microg g(-1) creatinine or 16% of the recovery desmosine value. We conclude that there is a small but statistically significant increase in lung elastin breakdown in the body during an acute exacerbation of COPD...
  51. ncbi request reprint Micellar electrokinetic chromatography for the determination of urinary desmosine and isodesmosine in patients affected by chronic obstructive pulmonary disease
    S Viglio
    Dipartimento di Biochimica A Castellani, Universita di Pavia, Italy
    J Chromatogr B Biomed Sci Appl 714:87-98. 1998
    ..Thus micellar electrokinetic chromatography (MEKC) may be considered as a reliable technique for studying the turnover of the elastic fiber in clinical conditions...
  52. ncbi request reprint A fast amplification-reverse hybridization assay kit to detect the most frequent deficient variants in the alpha-1-antitrypsin gene
    M Zorzetto
    Laboratorio di Biochimica e Genetica, Clinica di Malattie dell Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita di Pavia, Italia
    Respiration 69:81-5. 2002
    ..The gold standard for its laboratory diagnosis is thin-layer isoelectric focusing, which should be performed in reference laboratories...
  53. ncbi request reprint Tumour necrosis factor family genes in a phenotype of COPD associated with emphysema
    I Ferrarotti
    Dept of Respiratory Diseases, IRCCS San Matteo Hospital, University of Pavia, Pavia, Italy
    Eur Respir J 21:444-9. 2003
    ..Nevertheless, the authors would like to emphasise the importance of narrowing the phenotype in the search for genetic risk factors in chronic obstructive pulmonary disease...
  54. ncbi request reprint Long-term durable benefit after whole lung lavage in pulmonary alveolar proteinosis
    M Beccaria
    Respiratory Diseases Division, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico S Matteo, University of Pavia, Pavia, Italy
    Eur Respir J 23:526-31. 2004
    ..In conclusion, whole lung lavage for idiopathic pulmonary alveolar proteinosis is currently a safe procedure in an experienced setting, and provides long-lasting benefits in the majority of patients...
  55. ncbi request reprint "The sarcoidosis map": a joint survey of clinical and immunogenetic findings in two European countries
    M Martinetti
    Servizio di Immunoematologia e Transfusione, IRCCS Policlinico San Matteo, Pavia, Italy
    Am J Respir Crit Care Med 152:557-64. 1995
    ..Our results seem to support the concept that immunogenetic background may at least partly account for the clinical heterogeneity of sarcoidosis...
  56. ncbi request reprint Ongoing research in Europe: Alpha One International Registry (AIR) objectives and development
    R A Stockley
    Dept of Medicine, University Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK
    Eur Respir J 29:582-6. 2007
    ..The success related to the convergence of national registries into a common database creating a unique registry beyond geographic boundaries and encompassing alpha1-antitrypsin deficiency from various ethnic groups...
  57. pmc Prevalence and phenotype of subjects carrying rare variants in the Italian registry for alpha1-antitrypsin deficiency
    I Ferrarotti
    J Med Genet 42:282-7. 2005
  58. ncbi request reprint Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles
    F J de Serres
    Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Monaldi Arch Chest Dis 63:133-41. 2005
    ..This genetic disease is known to exist in Italy and is related to a high risk for development of jaundice in infants, liver disease in children and adults, and pulmonary emphysema in adults...
  59. ncbi request reprint [American Thoracic Society/European Respiratory Society Statement: Standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency]
    J K Stoller
    Pneumologie 59:36-68. 2005
  60. ncbi request reprint Alpha-1 antitrypsin deficiency: from Italy to the world
    B Balbi
    Monaldi Arch Chest Dis 67:176-8. 2007
  61. ncbi request reprint Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaprose
    E Korzus
    Department of Biochemistry, University of Georgia, Athens 30602
    Biol Chem Hoppe Seyler 375:335-41. 1994
    ....
  62. ncbi request reprint Complete mutational screening of the CFTR gene in 120 patients with pulmonary disease
    C Bombieri
    Istituto di Biologia e Genetica, Universita di Verona, Italy
    Hum Genet 103:718-22. 1998
    ..These results confirm the involvement of the CFTR gene in disseminated bronchiectasis of unknown origin, and suggest a possible role for CFTR gene mutations in sarcoidosis, and for the 5T allele in pulmonary emphysema...