F Locatelli

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi Membranous glomerulopathy in children given allogeneic hematopoietic stem cell transplantation
    Silverio Perrotta
    Department of Pediatrics, Second University of Naples, Italy
    Haematologica 90:ECR31. 2005
  2. ncbi The outcome of children with Fanconi anemia given hematopoietic stem cell transplantation and the influence of fludarabine in the conditioning regimen: a report from the Italian pediatric group
    Franco Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Pavia, Italy
    Haematologica 92:1381-8. 2007
  3. pmc Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors
    Maria Antonietta Avanzini
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Haematologica 94:1649-60. 2009
  4. pmc Transplantation and innate immunity: the lesson of natural killer cells
    Alice Bertaina
    Paediatric Haematology Oncology, University of Pavia, Foundation IRCCS Policlinico San Matteo, Pavia, Italy
    Ital J Pediatr 35:44. 2009
  5. pmc Safety and efficacy of a caspofungin-based combination therapy for treatment of proven or probable aspergillosis in pediatric hematological patients
    Simone Cesaro
    Pediatric Hematology Oncology, Department of Pediatrics, University of Padua, Italy
    BMC Infect Dis 7:28. 2007
  6. ncbi Innovative approaches of adoptive immune cell therapy in paediatric recipients of haematopoietic stem cell transplantation
    Franco Locatelli
    Paediatric Haematology and Oncology, IRCCS Policlinico San Matteo, P le Golgi, 2, 27100 Pavia, Italy
    Best Pract Res Clin Haematol 17:479-92. 2004
  7. ncbi Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial
    Franco Locatelli
    Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    Blood 105:410-9. 2005
  8. ncbi Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease
    Franco Locatelli
    Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Blood 101:2137-43. 2003
  9. ncbi New insights into haematopoietic stem cell transplantation for patients with haemoglobinopathies
    Franco Locatelli
    Oncoematologia Pediatrica, IRCCS Policlinico S Matteo, Pavia, Italy
    Br J Haematol 125:3-11. 2004
  10. doi Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia
    Franco Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Br J Haematol 147:371-8. 2009

Detail Information

Publications151 found, 100 shown here

  1. ncbi Membranous glomerulopathy in children given allogeneic hematopoietic stem cell transplantation
    Silverio Perrotta
    Department of Pediatrics, Second University of Naples, Italy
    Haematologica 90:ECR31. 2005
    ..Therefore, we strongly suggest regular urine analysis during the follow-up of children undergoing HSCT in order to diagnose MG early...
  2. ncbi The outcome of children with Fanconi anemia given hematopoietic stem cell transplantation and the influence of fludarabine in the conditioning regimen: a report from the Italian pediatric group
    Franco Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Pavia, Italy
    Haematologica 92:1381-8. 2007
    ..While in the past HSCT from an HLA-identical sibling was proven to cure many patients, a higher incidence of treatment failure has been reported in recipients of an unrelated donor (UD) or HLA-partially matched related allograft...
  3. pmc Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors
    Maria Antonietta Avanzini
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Haematologica 94:1649-60. 2009
    ..However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be influenced by both the cell source and culture conditions...
  4. pmc Transplantation and innate immunity: the lesson of natural killer cells
    Alice Bertaina
    Paediatric Haematology Oncology, University of Pavia, Foundation IRCCS Policlinico San Matteo, Pavia, Italy
    Ital J Pediatr 35:44. 2009
    ..This study represents a major breakthrough in the cure of otherwise fatal leukemias, providing information on the best criteria for choosing the optimal donor...
  5. pmc Safety and efficacy of a caspofungin-based combination therapy for treatment of proven or probable aspergillosis in pediatric hematological patients
    Simone Cesaro
    Pediatric Hematology Oncology, Department of Pediatrics, University of Padua, Italy
    BMC Infect Dis 7:28. 2007
    ..The recent development of new antifungal drugs gives the clinician the possibility to assess the combination of antifungal drugs with in-vitro or in animal-model synergistic effect...
  6. ncbi Innovative approaches of adoptive immune cell therapy in paediatric recipients of haematopoietic stem cell transplantation
    Franco Locatelli
    Paediatric Haematology and Oncology, IRCCS Policlinico San Matteo, P le Golgi, 2, 27100 Pavia, Italy
    Best Pract Res Clin Haematol 17:479-92. 2004
    ..In this regard, strategies of ex-vivo generation and expansion of clones or cell lines, specifically or preferentially leukaemia reactive, have been developed...
  7. ncbi Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial
    Franco Locatelli
    Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    Blood 105:410-9. 2005
    ..Disease recurrence remains the major cause of treatment failure. Outcome of UD-HSCT recipients is comparable to that of children receiving transplants from an HLA-identical sibling...
  8. ncbi Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease
    Franco Locatelli
    Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Blood 101:2137-43. 2003
    ..Related CBT for hemoglobinopathies offers a good probability of success and is associated with a low risk of GVHD. Optimization of transplantation strategies could further improve these results...
  9. ncbi New insights into haematopoietic stem cell transplantation for patients with haemoglobinopathies
    Franco Locatelli
    Oncoematologia Pediatrica, IRCCS Policlinico S Matteo, Pavia, Italy
    Br J Haematol 125:3-11. 2004
  10. doi Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia
    Franco Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Br J Haematol 147:371-8. 2009
    ..01). These data suggest that the clofarabine/cyclophosphamide/etoposide regimen is well tolerated and can induce clinical response in a relevant proportion of children with refractory/multiple relapsed ALL...
  11. ncbi The changing role of stem cell transplantation in childhood
    F Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Bone Marrow Transplant 41:S3-7. 2008
    ....
  12. doi Improving cord blood transplantation in children
    Franco Locatelli
    Paediatric Haematology Oncology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi, 2, Pavia 27100, Italy
    Br J Haematol 147:217-26. 2009
    ....
  13. ncbi Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission
    Franco Locatelli
    Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Universita di Pavia, Italy
    Blood 101:1611-9. 2003
    ..The results obtained in this analysis can be of help in designing prospective studies of autologous HSCT in children with AML in first CR...
  14. ncbi Cyclosporin A and short-term methotrexate versus cyclosporin A as graft versus host disease prophylaxis in patients with severe aplastic anemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO/EBMT randomized
    F Locatelli
    Dipartimento di Scienze Pediatriche, Universita di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Blood 96:1690-7. 2000
    ..05). These data indicate that the use of CsA with MTX is associated with improved survival in patients with SAA who receive transplants from compatible siblings. (Blood. 2000;96:1690-1697)..
  15. ncbi Mobilization and selection of peripheral blood hematopoietic progenitors in children with systemic sclerosis
    F Locatelli
    Dipartimento di Scienze Pediatriche, Universita di Pavia, IRCCS Policlinico San Matteo, P le Golgi 2, 27100 Pavia, Italy
    Haematologica 84:839-43. 1999
    ..We report on three children affected by systemic sclerosis with lung involvement, who received chemotherapy and granulocyte colony-stimulating factor (G-CSF) to mobilize autologous peripheral blood progenitors...
  16. ncbi Incidence and pathogenesis of tumor lysis syndrome
    Franco Locatelli
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy
    Contrib Nephrol 147:61-8. 2005
    ..A good comprehension of TLS pathophysiology has provided the basis for an effective and rational treatment of this complication, adversely affecting the outcome of cancer patients...
  17. ncbi Graft versus host disease prophylaxis with low-dose cyclosporine-A reduces the risk of relapse in children with acute leukemia given HLA-identical sibling bone marrow transplantation: results of a randomized trial
    F Locatelli
    Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Blood 95:1572-9. 2000
    ..15). Our data demonstrate that the use of low Cs-A doses is associated with a statistically significant reduction of leukemia relapse, probably due to an increased graft versus leukemia effect. (Blood. 2000;95:1572-1579)..
  18. ncbi Tolerance and hematopoietic stem cell transplantation 50 years after Burnet's theory
    F Locatelli
    Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Exp Hematol 28:479-89. 2000
    ..Here, we attempt to analyze critically new clinical and experimental strategies aimed at inducing alloantigen-specific unresponsiveness...
  19. ncbi T-cell depletion to prevent GVHD after unrelated-donor marrow transplantation
    Franco Locatelli
    Paediatric Haematology and Oncology, IRCCS Policlinico San Matteo, Pavia 27100, Italy
    Lancet 366:692-4. 2005
  20. ncbi Analysis of immune reconstitution in children undergoing cord blood transplantation
    A Moretta
    Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Exp Hematol 29:371-9. 2001
    ..This prompt immune recovery possibly was favored by the reduced incidence and severity of GVHD observed in children who underwent CBT...
  21. ncbi Hematopoietic and immune recovery after transplantation of cord blood progenitor cells in children
    F Locatelli
    Department of Pediatrics, IRCCS Policlinico S Matteo University of Pavia, Italy
    Bone Marrow Transplant 18:1095-101. 1996
    ..The reconstitution of erythropoiesis seems to recapitulate the ontogenetic pattern and the kinetics of recovery of the immune system reproduce that observed after BMT with the peculiarity of B cell expansion in peripheral blood...
  22. ncbi Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors
    F Locatelli
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Leukemia 16:2228-37. 2002
    ..EFS of unrelated donor HSCT in children with ALL in second CR has improved in the last few years, mainly due to a decreased TRM. This information is of value for counseling of patients with relapsed ALL...
  23. ncbi Ex vivo priming for long-term maintenance of antileukemia human cytotoxic T cells suggests a general procedure for adoptive immunotherapy
    D Montagna
    BMT Laboratory and BMT Units, Department of Pediatrics, Laboratory of Organ Transplantation, IRCCS Policlinico San Matteo, University of Pavia, Italy
    Blood 98:3359-66. 2001
    ....
  24. ncbi Total body irradiation, thiotepa, and cyclophosphamide as a conditioning regimen for children with acute lymphoblastic leukemia in first or second remission undergoing bone marrow transplantation with HLA-identical siblings
    M Zecca
    Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    J Clin Oncol 17:1838-46. 1999
    ....
  25. ncbi Human alloantigen-specific anergic cells induced by a combination of CTLA4-Ig and CsA maintain anti-leukemia and anti-viral cytotoxic responses
    P Comoli
    Department of Pediatric Sciences, University of Pavia, IRCCS Policlinic S Matteo, Italy
    Bone Marrow Transplant 27:1263-73. 2001
    ..Our data provide the first direct in vitro evidence that it is possible to preserve antiviral and antileukemia effector cells after blockade of CD28/B7 interaction during MLR...
  26. ncbi Low incidence of severe acute graft-versus-host disease in children given haematopoietic stem cell transplantation from unrelated donors prospectively matched for HLA class I and II alleles with high-resolution molecular typing
    S Giebel
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Bone Marrow Transplant 31:987-93. 2003
    ..The observed outcome is comparable to that of children transplanted from HLA-identical siblings...
  27. doi Allogeneic stem cell transplantation for children with acute myeloid leukemia in second complete remission
    Franca Fagioli
    Oncoematologia Pediatrica, Ospedale Infantile Regina Margherita, Torino, Italy
    J Pediatr Hematol Oncol 30:575-83. 2008
    ..Both leukemia recurrence and TRM contributed to treatment failure. Optimization of donor selection and of strategies for both prophylaxis and treatment of graft-versus-host disease may improve the results of unrelated donor allo-HSCT...
  28. ncbi T cell therapy of Epstein-Barr virus and adenovirus infections after hemopoietic stem cell transplant
    P Comoli
    Pediatric Hematology Oncology, and Virology Service, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy
    Blood Cells Mol Dis 40:68-70. 2008
    ..Future prospectives include the transfer of this technology to treat AdV-related complications following HSCT...
  29. ncbi Extracorporeal photochemotherapy for treatment of acute and chronic GVHD in childhood
    L Salvaneschi
    Immunohematology and Transfusion Service, Center for Transplant Immunology, and the Pediatric Hematology Oncology Division, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Transfusion 41:1299-305. 2001
    ..However, data on children given this therapy are scarce. A Phase I-II study was carried out on EPC in children experiencing GVHD after allogeneic transplantation of HPCs...
  30. doi Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation
    M E Bernardo
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Bone Marrow Transplant 46:200-7. 2011
    ..Although these data do not support the use of MSCs in UCBT to support hematopoietic engraftment, they suggest that MSCs, possibly because of their immunosuppressive effect, may abrogate life-threatening acute GVHD and reduce early TRM...
  31. ncbi Hematopoietic stem cell transplantation in childhood: report from the bone marrow transplantation group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    A Pession
    Department of Pediatrics, University of Bologna, Ospedle Sant Orsola, Bologna, Italy
    Haematologica 85:638-46. 2000
    ..Transplant procedures and indications have changed considerably during recent years. Monitoring of information about these changes is useful for interpretation of nationwide collected data...
  32. ncbi Preemptive therapy of EBV-related lymphoproliferative disease after pediatric haploidentical stem cell transplantation
    P Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Am J Transplant 7:1648-55. 2007
    ..We conclude that preemptive therapy with rituximab is safe, but only partly effective in haplo-HSCT recipients. Patients who progress to PTLD under rituximab treatment can be rescued permanently by infusion of EBV-specific CTLs...
  33. ncbi Successful T-cell-depleted, related haploidentical peripheral blood stem cell transplantation in a patient with Fanconi anaemia using a fludarabine-based preparative regimen without radiation
    G Rossi
    Oncoematologia Pediatricia, IRCCS Policlinico San Matteo, Pavia, Italy
    Bone Marrow Transplant 31:437-40. 2003
    ..At 18 months after transplantation, she is well with 100% donor chimerism and has recovered normal immune function...
  34. doi Narrowband ultraviolet B phototherapy in the treatment of cutaneous graft-versus-host disease in oncohaematological paediatric patients
    V Brazzelli
    Department of Human and Hereditary Pathology, Institute of Dermatology, University of Pavia and Foundation IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy
    Br J Dermatol 162:404-9. 2010
    ..In recent years, narrowband ultraviolet B (NB-UVB, 311-313 nm) has been found to be a beneficial adjuvant treatment in patients refractory to first-line immunosuppressive drugs...
  35. ncbi Donor-recipient incompatibility at CD31-codon 563 is a major risk factor for acute graft-versus-host disease after allogeneic bone marrow transplantation from a human leucocyte antigen-matched donor
    C L Balduini
    Department of Internal Medicine, IRCCS San Matteo University of Pavia, 27100 Pavia, Italy
    Br J Haematol 114:951-3. 2001
    ..We suggest that donor/recipient compatibility at CD31-codon 563 should be added to HLA-typing for donor selection and/or adjustment of aGVHD prophylaxis...
  36. doi Isomorphic cutaneous graft-versus-host disease reaction after ultraviolet exposure: clinical, histological and direct immunofluorescence studies of four allo-transplanted patients
    C Vassallo
    Department of Dermatology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    J Eur Acad Dermatol Venereol 23:913-8. 2009
    ..If experimental studies and clinical observations could partially elucidate the pathophysiology of acute GVHD, the biology of chronic GVHD is still much less well understood...
  37. doi Correlation of rhinovirus load in the respiratory tract and clinical symptoms in hospitalized immunocompetent and immunocompromised patients
    G Gerna
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Med Virol 81:1498-507. 2009
    ....
  38. doi Expansion of antileukaemia CTL lines and clones for adoptive cell therapy in paediatric patients given allogeneic haematopoietic stem cell transplantation
    D Montagna
    Department of Pediatrics, Laboratory of Immunology, University of Pavia, Italy
    Int J Immunogenet 35:389-93. 2008
    ..This strategy has to be tested in the clinical setting for proving its efficacy in preventing/treating leukaemia recurrence...
  39. pmc Human cytomegalovirus immediate-early mRNA detection by nucleic acid sequence-based amplification as a new parameter for preemptive therapy in bone marrow transplant recipients
    G Gerna
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Universita di Pavia, 27100 Pavia, Italy
    J Clin Microbiol 38:1845-53. 2000
    ..HCMV IE mRNA detection may represent a useful parameter for initiation of preemptive therapy in BMT recipients...
  40. ncbi Lung function abnormalities after bone marrow transplantation in children: has the trend recently changed?
    I Cerveri
    Clinic of Respiratory Diseases, Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy
    Chest 120:1900-6. 2001
    ..To evaluate early and late lung function abnormalities and their predictors in a large sample of children who underwent bone marrow transplantation (BMT) for leukemias in the 1990s, highlighting changes with respect to the 1980s...
  41. doi Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia
    V Conter
    Department of Pediatrics, University of Milano Bicocca, Ospedale S Gerardo, Monza, Italy
    Leukemia 24:255-64. 2010
    ..The introduction of minimal residual disease monitoring and evaluation of common randomized questions by AIEOP and BFM groups in the protocol AIEOP-BFM-ALL 2000 are expected to further ameliorate treatment of children with ALL...
  42. ncbi GMP production of anti-tumor cytotoxic T-cell lines for adoptive T-cell therapy in patients with solid neoplasia
    I Turin
    Immunology Laboratory and Pediatric Hematology Oncology, IRCCS Policlinico San Matteo, Milan, Italy
    Cytotherapy 9:499-507. 2007
    ..We have now investigated the possibility of producing large amounts of autologous anti-tumor CTL, in compliance with good manufacturing practices, for in vivo use...
  43. ncbi Vancomycin-resistant Enterococcus faecium infection in three children given allogeneic hematopoietic stem cell transplantation: clinical and microbiologic features
    E Carretto
    Laboratorio di Batteriologia e Micologia, Laboratori Sperimentali di Ricerca, Area Infettivologica, IRCCS Policlinico San Matteo, Viale Taramelli 5, 27100 Pavia, Italy
    Haematologica 85:1158-64. 2000
    ..The aim of this study is to report on the clinical and microbiological features of VRE infections in 3 children given hematopoietic stem cell transplantation (HSCT)...
  44. ncbi The immunosuppressive effect of human cytomegalovirus infection in recipients of allogeneic hematopoietic stem cell transplantation
    S Giebel
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy
    Bone Marrow Transplant 36:503-9. 2005
    ..However, pre emptive therapy with ganciclovir makes this immunosuppressive effect transient and restricted to the time of infection duration...
  45. ncbi Granular acute lymphoblastic leukemia in children. "Aieop Cooperative Group for Cytology of Acute Leukemias"
    R Invernizzi
    Clinica Medica 2, Universita di Pavia, Italy
    Haematologica 77:30-4. 1992
    ....
  46. ncbi Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood
    F Locatelli
    Department of Pediatrics, University of Pavia, Instituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Italy
    J Clin Oncol 15:566-73. 1997
    ..To evaluate the role of allogeneic bone marrow transplantation (BMT) in children with chronic myelomonocytic leukemia (CMML)...
  47. ncbi Prospective simultaneous quantification of human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in young recipients of allogeneic hematopoietic stem cell transplants
    Daniele Lilleri
    Servizio di Virologia, Instituto di Ricovero e Cura a Carattere Scientifico San Matteo, 27100 Pavia, Italy
    Blood 108:1406-12. 2006
    ....
  48. doi Human cytomegalovirus-specific T cell reconstitution in young patients receiving T cell-depleted, allogeneic hematopoietic stem cell transplantation
    Daniele Lilleri
    Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    J Infect Dis 199:829-36. 2009
    ..Scarce data on this subject are available for children receiving a T cell-depleted HSCT...
  49. doi Human cytomegalovirus-specific CD4(+) and CD8(+) T-cell response determination: comparison of short-term (24h) assays vs long-term (7-day) infected dendritic cell assay in the immunocompetent and the immunocompromised host
    Paola Zelini
    Service of Virology and Microbiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Clin Immunol 136:269-81. 2010
    ..A significant correlation between iDC-activated T-cells and T-cells activated by either iCL or the pep-pool was observed. In conclusion, whenever a rapid result is needed, short-term assays may efficiently replace the iDC assay...
  50. ncbi Incidence of, and risk factors for, nosocomial infections among hematopoietic stem cell transplantation recipients, with impact on procedure-related mortality
    C Marena
    Department of Hematology, Pediatric Hematology-Oncology, IRCCS San Matteo Hospital, Pavia, Italy
    Infect Control Hosp Epidemiol 22:510-7. 2001
    ..Because BSIs are life-threatening complications for HSCT recipients, preventive measures aimed at reducing the incidence of these infections among patients given HSCT should be adopted...
  51. doi Platelet size distinguishes between inherited macrothrombocytopenias and immune thrombocytopenia
    P Noris
    Department of Internal Medicine, University of Pavia, Pavia, Italy
    J Thromb Haemost 7:2131-6. 2009
    ..Although it is known that the most common inherited forms of thrombocytopenia are characterized by increased platelet size, the diagnostic power of this feature has never been investigated...
  52. ncbi Anti-CD20 monoclonal antibody for the treatment of severe, immune-mediated, pure red cell aplasia and hemolytic anemia
    M Zecca
    Pediatric Hematology/Oncology, IRCCS Policlinico San Matteo, University of Pavia, P. le Golgi 2, I-27100 Pavia, Italy
    Blood 97:3995-7. 2001
    ..This case suggests a role of anti-CD20 monoclonal antibody for treatment of patients with antibody-mediated hematologic disorders. (Blood. 2001;97:3995-3997)..
  53. ncbi Bartonella-related pseudomembranous angiomatous papillomatosis of the oral cavity associated with allogeneic bone marrow transplantation and oral graft-versus-host disease
    C Vassallo
    Department of Dermatology, Istituto di Ematologia, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Br J Dermatol 157:174-8. 2007
    ..All the lesions healed after systemic antibiotic therapy, although some recurred after months, and regressed again after systemic antibiotic treatment associated with conservative surgical excision...
  54. ncbi Successful in vitro priming of EBV-specific CD8+ T cells endowed with strong cytotoxic function from T cells of EBV-seronegative children
    P Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico S Matteo, 27100 Pavia, Italy
    Am J Transplant 6:2169-76. 2006
    ..In conclusion, it is feasible to activate EBV-specific CD8+ CTL with suitable characteristics for in vivo employment from EBV-seronegative children...
  55. ncbi Quantitative ultrasound detects bone changes following bone marrow transplantation in pediatric subjects with hematological diseases: a longitudinal study
    N Di Iorgi
    Department of Pediatrics, IRCCS G Gaslini, University of Genoa, Largo G Gaslini 5, 16147 Genoa, Italy
    J Endocrinol Invest 33:478-82. 2010
    ..Bone marrow transplantation (BMT) is associated with bone morbidity. We investigated bone status with quantitative ultrasound (QUS) in pediatric patients with hematological diseases prior to and up to 3 yr following BMT...
  56. ncbi Role of a hematopoietic stem cell transplant registry in childhood: the experience of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    Andrea Pession
    Department of Pediatrics, University of Bologna, Ospedale Sant Orsola, Bologna, Italy
    Haematologica 87:42-6. 2002
  57. doi Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference
    Franco Locatelli
    Pediatric Hematology Oncology, University of Pavia, IRCCS Foundation, Policlinico San Matteo, Pavia, Italy
    Clin Immunol 133:171-8. 2009
    ..In view of the favorable clinical outcome of children with chemo-resistant ALL, Haplo HSCT from an NK-alloreactive relative could become a first option in these high-risk leukemia patients...
  58. doi Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in patients with thalassaemia major
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Br J Haematol 143:548-51. 2008
    ..This regimen might find elective application in patients at high risk of developing life-threatening complications...
  59. ncbi Low percentages of circulating CD8(+)/CD45RA(+) human T lymphocytes expressing beta7 integrin correlate with the occurrence of intestinal acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    M Antonietta Avanzini
    Pediatric Hematology Oncology and Laboratory of Transplant Immunology, IRCCS Policlinico San Matteo Pavia, University of Pavia, Pavia, Italy
    Exp Hematol 34:1429-34. 2006
    ..Therefore, we evaluated the correlation existing between circulating beta7(+) T-lymphocyte subsets early after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and occurrence of a-GVHD...
  60. ncbi Graft rejection after unrelated donor hematopoietic stem cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction
    Katharina Fleischhauer
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, P le Golgi 2, 27100 Pavia, Italy
    Blood 107:2984-92. 2006
    ..82; P = .01). These data suggest that in patients with thalassemia, the incidence of graft failure after HSCT may be reduced by appropriate selection of UDs, with such selection taking into account the functional rules of immunogenetics...
  61. doi Automated washing of human progenitor cells: evaluation of apoptosis and cell necrosis
    M C Scerpa
    SIMT, IRCCS Bambino Gesù Pediatric Hospital, Rome, Italy
    Transfus Med 21:402-7. 2011
    ..The critical importance of cell dose in the clinical outcome, after transplant, has motivated the need to develop techniques aimed at reducing cell losses and increasing reproducibility...
  62. ncbi Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute
    M E Bernardo
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    J Cell Physiol 211:121-30. 2007
    ....
  63. ncbi Human mesenchymal stem cells derived from bone marrow display a better chondrogenic differentiation compared with other sources
    M E Bernardo
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Connect Tissue Res 48:132-40. 2007
    ..As MSCs represent an attractive tool for cartilage tissue repair strategies, our data suggest that bone marrow should be considered the preferred MSC source for these therapeutic approaches...
  64. ncbi Rehabilitation of chronic graft versus host disease in children. A clinical series
    G Carenzio
    Department of Physical Medicine and Rehabilitation, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Eura Medicophys 43:445-50. 2007
    ..We believe that cGVHD is a pathology which must be seen by a physiatrist as early as possible at onset of first cutaneous signs of cGVHD to limit its invalidating evolution...
  65. ncbi Donor/recipient mixed chimerism does not predict graft failure in children with beta-thalassemia given an allogeneic cord blood transplant from an HLA-identical sibling
    Daniela Lisini
    Oncoematologia Pediatrica, Laboratorio di Immunologia dei Trapianti, Fondazione IRCCS Policlinico San Matteo, P le Golgi, 2, I 27100 Pavia, Italy
    Haematologica 93:1859-67. 2008
    ..We investigated the relationship between the degree of mixed chimerism over time and clinical outcome of children undergoing cord blood transplantation for beta-thalassemia...
  66. ncbi Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation
    Patrizia Comoli
    Laboratorio Sperimentale di Trapianto di Midollo Osseo, Oncoematologia Pediatrica, Fondazione IRCCS Policlinico S Matteo, Universita di Pavia, V le Golgi 19, 27100 Pavia, Italy
    Nephrol Dial Transplant 23:1196-202. 2008
    ..Mesenchymal stem cells (MSCs) have immunomodulatory capacity, since in vivo they may prolong skin graft survival in the animal model and can rescue patients with life-threatening graft-versus-host disease...
  67. doi The role of reduced intensity preparative regimens in patients with thalassemia given hematopoietic transplantation
    Alice Bertaina
    Department of Paediatric Haematology Oncology, University of Pavia, Ospedale Bambino Gesu, Rome, Italy
    Ann N Y Acad Sci 1202:141-8. 2010
    ..This novel approach is a promising alternative for reducing the risk of life-threatening complications and increasing the number of TM patients successfully cured with an allograft...
  68. ncbi T-cell lines specific for peptides of adenovirus hexon protein and devoid of alloreactivity against recipient cells can be obtained from HLA-haploidentical donors
    Patrizia Comoli
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    J Immunother 31:529-36. 2008
    ..These T cells may be safely employed for adoptive treatment of HAdV complications...
  69. doi Spinal osteomyelitis due to Aspergillus flavus in a child: a rare complication after haematopoietic stem cell transplantation
    Giampiero Beluffi
    Section of Paediatric Radiology, Department of Radiodiagnosis, Fondazione IRCCS Policlinico S Matteo, Viale C Golgi 19, I 27100 Pavia PV, Italy
    Pediatr Radiol 38:709-12. 2008
    ..The diagnosis was difficult on a clinical basis, but made possible by conventional radiography and MRI...
  70. ncbi Single-cell cloning of human, donor-derived antileukemia T-cell lines for in vitro separation of graft-versus-leukemia effect from graft-versus-host reaction
    Daniela Montagna
    Department of Pediatrics, Laboratory of Immunology, University of Pavia, Italy
    Cancer Res 66:7310-6. 2006
    ....
  71. ncbi Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia
    Daniela Montagna
    Dipartimento di Scienze Pediatriche, Universita di Pavia, IRCCS Policlinico San Matteo, P le Golgi 2, 27100 Pavia, Italy
    Blood 108:3843-50. 2006
    ....
  72. ncbi Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving hematopoietic stem-cell transplantation compared with qualitative pp65 antigenemia
    Daniele Lilleri
    Servizio di Virologia, Universita di Pavia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, Pavia, Italy
    Blood 110:2757-60. 2007
    ..259), the number of patients treated was significantly lower in the DNAemia arm (18% vs 31%, P = .026). No patient developed HCMV disease. The use of a DNAemia cut-off avoids unnecessary antiviral treatment...
  73. doi Extracorporeal photochemotherapy in graft-versus-host disease: a longitudinal study on factors influencing the response and survival in pediatric patients
    Cesare Perotti
    Immunohaematology and Transfusion Service, Apheresis and Cell Therapy Unit, Fondazione IRCCS Policlinico S Matteo, 27100 Pavia, Italy
    Transfusion 50:1359-69. 2010
    ..No standard clinical and laboratory criteria of response to ECP treatment are available at the moment...
  74. pmc Kinetics of Epstein-Barr virus DNA load in different blood compartments of pediatric recipients of T-cell-depleted HLA-haploidentical stem cell transplantation
    Fausto Baldanti
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    J Clin Microbiol 46:3672-7. 2008
    ....
  75. doi Cord blood transplantation in patients with hemoglobinopathies
    Agata Boncimino
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Transfus Apher Sci 42:277-81. 2010
    ..Available evidence indicates that related donor CBT is a safe and effective option for patients with hemoglobinopathies, able to offer results at least as good as those reported using bone marrow cells...
  76. ncbi Ex vivo generation and expansion of anti-tumor cytotoxic T-cell lines derived from patients or their HLA-identical sibling
    Daniela Montagna
    Immunology Laboratory and Pediatric Hematology Oncology, IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi, 27100 Pavia, Italy
    Int J Cancer 110:76-86. 2004
    ..Altogether these results demonstrate that our experimental approach is suitable for efficiently generating and expanding anti-solid tumor CTL to be used for adoptive immunotherapy...
  77. ncbi B lymphocyte reconstitution after hematopoietic stem cell transplantation: functional immaturity and slow recovery of memory CD27+ B cells
    Maria Antonietta Avanzini
    Laboratorio di Immunologia dei Trapianti e Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, University of Pavia, Pavia, Italy
    Exp Hematol 33:480-6. 2005
    ..HSCT recipients may obtain protective titers of pathogen-specific antibody through vaccination, but optimal timing of reimmunization remains to be defined...
  78. ncbi T lymphocytes of recipient origin may contribute to the recovery of specific immune response toward viruses and fungi in children undergoing cord blood transplantation
    Daniela Montagna
    Dipartimento di Scienze Pediatriche, Università Pavia, IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100 Pavia, Italy
    Blood 103:4322-9. 2004
    ..Our results document, at a clonal level, that after CBT recovery of either polyclonal or pauciclonal T-cell response toward widespread pathogens is prompt, with some patients benefiting from a contribution of recipient-derived cells...
  79. ncbi Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype
    Rita Maccario
    Laboratorio di Immunologia dei Trapianti, Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, P le Golgi 19, 27100 Pavia, Italy
    Haematologica 90:516-25. 2005
    ..We extended the evaluation of mechanisms responsible for the immune regulatory effect derived from the interaction of human MSC with cells involved in alloantigen-specific immune response in mixed lymphocyte culture (MLC)...
  80. ncbi Rising antigenemia levels may be misleading in pre-emptive therapy of human cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
    Giuseppe Gerna
    Servizio di Virologia, Oncoematologia Pediatrica, and Centro Trapianti di Midollo Osseo, Divisione di Ematologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Haematologica 90:526-33. 2005
    ..This raises some doubts about the therapeutic decisions to be taken...
  81. ncbi Dendritic cells pulsed with polyomavirus BK antigen induce ex vivo polyoma BK virus-specific cytotoxic T-cell lines in seropositive healthy individuals and renal transplant recipients
    Patrizia Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico S Matteo, Pavia, Italy
    J Am Soc Nephrol 14:3197-204. 2003
    ..Application of this culture system may allow a preemptive therapy approach to BKV-related complications in transplant recipients, based on CTL treatment guided by BKV DNA levels...
  82. ncbi Generation and ex vivo expansion of cytotoxic T lymphocytes directed toward different types of leukemia or myelodysplastic cells using both HLA-matched and partially matched donors
    Daniela Montagna
    Oncoematologia Pediatrica, Laboratorio d Immunologia dei Trapianti, Universita di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Exp Hematol 31:1031-8. 2003
    ..In this study, we evaluated the possibility of generating and expanding in vitro CTL directed toward different types of either leukemia or myelodysplastic cells, using both HLA-matched and partially matched donors...
  83. ncbi Treatment of EBV-related post-renal transplant lymphoproliferative disease with a tailored regimen including EBV-specific T cells
    Patrizia Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico S Matteo, Pavia, Italy
    Am J Transplant 5:1415-22. 2005
    ..These preliminary results suggest that a combined chemoimmunotherapy regimen including virus-specific T-cells is well tolerated and potentially effective as first-line treatment of EBV-related PTLD...
  84. ncbi Human cytomegalovirus immediate-early mRNAemia versus pp65 antigenemia for guiding pre-emptive therapy in children and young adults undergoing hematopoietic stem cell transplantation: a prospective, randomized, open-label trial
    Giuseppe Gerna
    Servizio di Virologia, Division di Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattee Scientifico Policlinico San Matteo, Pavia, Italy
    Blood 101:5053-60. 2003
    ..Although these data indicate that IEmRNA determination does not offer advantages in terms of treatment duration, it can safely replace antigenemia, while semiautomation is the major advantage of the NASBA procedure...
  85. ncbi Polyomavirus BK-specific immunity after kidney transplantation
    Patrizia Comoli
    Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy
    Transplantation 78:1229-32. 2004
    ..Our preliminary data suggest that lack of protective immunity toward BKV may favor the occurrence of BKV active infection and influence the progression to PVAN...
  86. ncbi Infusion of autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for prevention of EBV-related lymphoproliferative disorder in solid organ transplant recipients with evidence of active virus replication
    Patrizia Comoli
    Department of Pediatrics, Immunology Laboratory, IRCCS Policlinico S Matteo, P le Golgi 2, 27100 Pavia, Italy
    Blood 99:2592-8. 2002
    ..This approach may, therefore, be safely used as prophylaxis of EBV-related lymphoproliferative disorders in these patients, following a strategy of preemptive therapy guided by EBV DNA levels...
  87. ncbi Chronic graft-versus-host disease in children: incidence, risk factors, and impact on outcome
    Marco Zecca
    Oncoematologia Pediatrica, Universita di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Blood 100:1192-200. 2002
    ..Use of CB stem cells and preparative regimens without radiotherapy may prevent its development. In patients affected by ALL, cGVHD was associated with a strong graft-versus-leukemia effect, improving DFS...
  88. ncbi Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes
    Patrizia Comoli
    Laboratorio di Ricerca Area Trapianti e Oncoematologia Pediatrica, IRCCS Policlinico S Matteo, V le Golgi 19, 27100 Pavia, Italy
    J Clin Oncol 23:8942-9. 2005
    ..We conducted a clinical trial of EBV-targeted cell therapy with autologous virus-specific cytotoxic T lymphocytes (CTLs) for NPC refractory to conventional treatments...
  89. ncbi Evaluation of the effect of medroxyprogesterone acetate on bone marrow progenitor cells
    P Pedrazzoli
    Divisione di Oncologia, Fondazione Clinica del Lavoro, Pavia, Italy
    Tumori 77:399-402. 1991
    ..In addition, the supposed mechanism of rendering stem cells less susceptible to the insult of cytotoxic drugs by lowering the number of progenitors in the S-phase has been ruled out by cell kinetic studies...
  90. ncbi A new sensitive enzyme-linked immunosorbent assay (ELISA) for Alemtuzumab determination: development, validation and application
    M Montagna
    Clinical Pharmacokinetics Unit, IRCCS Fondazione Policlinico S Matteo, Pavia, Italy
    Int J Immunopathol Pharmacol 20:363-71. 2007
    ..This ELISA assay could be easily used to determine human serum levels of Alemtuzumab pre- and post-treatment to optimize dosing and scheduling and to study the relationship between dose and clinical response...
  91. doi Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Cytotherapy 11:825-36. 2009
    ..The aim of the study was in vitro characterization of MSC from active CD patients for future clinical application...
  92. ncbi Late relapse of childhood acute lymphoblastic leukemia and pcr-monitoring of minimal residual disease: how much time can elapse between "molecular" and clinical relapse?
    Maurizio Arico
    Oncoematologia Pediatrica, Ospedale dei Bambini G Di Cristina, 90100 Palermo, Italy
    Haematologica 87:ELT19. 2002
  93. ncbi Familial platelet disorder with propensity to acute myelogenous leukemia: genetic heterogeneity and progression to leukemia via acquisition of clonal chromosome anomalies
    Antonella Minelli
    Biologia Generale e Genetica Medica, Universita di Pavia, Pavia, Italy
    Genes Chromosomes Cancer 40:165-71. 2004
    ....
  94. ncbi Gonadal and uterine function in female survivors treated by chemotherapy, radiotherapy, and/or bone marrow transplantation for childhood malignant and non-malignant diseases
    F Beneventi
    Department of Obstetrics and Gynaecology, IRCSS S Matteo Hospital, Pavia, Italy
    BJOG 121:856-65. 2014
    ..To evaluate gonadal function and uterine volume in a cohort of female survivors treated by chemotherapy, radiotherapy, and/or stem cell transplantation (SCT) for childhood malignant and non-malignant diseases...
  95. doi Clinical severity and molecular typing of human rhinovirus C strains during a fall outbreak affecting hospitalized patients
    A Piralla
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    J Clin Virol 45:311-7. 2009
    ..The circulation rate and the clinical severity of infections caused by members of the new human rhinovirus C (HRV-C) species remain to be defined...
  96. ncbi Alternative therapies and the Di Bella affair in pediatrics. A questionnaire submitted to Italian pediatric oncologists and hematologists
    G R Burgio
    Dipartimento di Scienze Pediatriche, Universita di Pavia, IRCCS Policlinico San Matteo, P le Golgi 2, 27100 Pavia, Italy f
    Haematologica 85:189-94. 2000
    ..Many Italian oncologists and hematologists had to cope with the problems that it introduced and the treatment also elicited heated reactions all over Europe. We attempted to evaluate the impact of this treatment on children with cancer...
  97. ncbi Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma
    P Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, IRCCS Policlinico S Matteo, Pavia, Italy
    Ann Oncol 15:113-7. 2004
    ..EBV-specific immunity, as well as T-cell repertoire in the tumor, before and after immunotherapy, was evaluated...
  98. ncbi Compound heterozygosity for two different amino-acid substitution mutations in the thrombopoietin receptor (c-mpl gene) in congenital amegakaryocytic thrombocytopenia (CAMT)
    R Tonelli
    Department of Pediatrics, University of Bologna, Italy
    Hum Genet 107:225-33. 2000
    ..The present study provides important confirmation that CAMT can be associated with (c-mpl) mutations...
  99. doi WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
    Emilio Paolo Alessandrino
    Division of Hematology, University of Pavia, Fondazione Policlinico San Matteo, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS, Pavia, Italy
    Blood 112:895-902. 2008
    ..013 and P = .031, respectively). In these patients, WPSS identified 2 groups with different OS and TRM. These data suggest that WHO classification and WPSS have a relevant prognostic value in posttransplantation outcome of MDS patients...
  100. doi The isochromosome i(7)(q10) carrying c.258+2t>c mutation of the SBDS gene does not promote development of myeloid malignancies in patients with Shwachman syndrome
    A Minelli
    Genetica Medica, Fondazione IRCCS Policlinico San Matteo Università di Pavia e, Pavia, Italy
    Leukemia 23:708-11. 2009
    ..258+2T>C, and we suggest that, as the c.258+2T>C mutation still allows the production of some amount of normal protein, this may contribute to the low incidence of MDS/AML in this subset of SDS patients...
  101. ncbi Variations of the perforin gene in patients with autoimmunity/lymphoproliferation and defective Fas function
    Rita Clementi
    Pediatric Haematology Oncology, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Blood 108:3079-84. 2006
    ..A91V patients displayed lower NK activity than controls. These data suggest that perforin variations are a susceptibility factor for ALPS/DALD development in subjects with defective Fas function and may influence disease expression...