Giuseppe Lippi

Summary

Affiliation: University of Parma
Country: Italy

Publications

  1. doi Biochemical markers for the diagnosis of venous thromboembolism: the past, present and future
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy
    J Thromb Thrombolysis 30:459-71. 2010
  2. ncbi Low volume tubes are not effective to reduce the rate of hemolyzed specimens from the emergency department
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy Electronic address
    Clin Biochem 47:227-9. 2014
  3. ncbi Adiponectin and migraine: systematic review of clinical evidence
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    Neurol Sci 35:1167-71. 2014
  4. ncbi Lack of harmonization of red blood cell distribution width (RDW). Evaluation of four hematological analyzers
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Italy Electronic address
    Clin Biochem 47:1100-3. 2014
  5. ncbi Homocysteine and migraine. A narrative review
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy Electronic address
    Clin Chim Acta 433:5-11. 2014
  6. ncbi Urgent monitoring of direct oral anticoagulants in patients with atrial fibrillation: a tentative approach based on routine laboratory tests
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    J Thromb Thrombolysis 38:269-74. 2014
  7. ncbi Early kinetics of heart-type fatty acid binding protein in patients undergoing dipyridamole stress echocardiography and relationship with high-sensitivity troponin
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Haematology, Academic Hospital of Parma, Parma, Italy
    Kardiol Pol 72:527-33. 2014
  8. ncbi Biological markers in older people at risk of mobility limitations
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Via Gramsci, 14, 43126 Parma, Italy
    Curr Pharm Des 20:3222-44. 2014
  9. pmc Interference of medical contrast media on laboratory testing
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    Biochem Med (Zagreb) 24:80-8. 2014
  10. pmc Avoidance to wipe alcohol before venipuncture is not a source of spurious hemolysis
    Gian Luca Salvagno
    Department of Life and Reproduction Sciences, University of Verona, Verona, Italy
    Biochem Med (Zagreb) 23:201-5. 2013

Detail Information

Publications139 found, 100 shown here

  1. doi Biochemical markers for the diagnosis of venous thromboembolism: the past, present and future
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy
    J Thromb Thrombolysis 30:459-71. 2010
    ....
  2. ncbi Low volume tubes are not effective to reduce the rate of hemolyzed specimens from the emergency department
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy Electronic address
    Clin Biochem 47:227-9. 2014
    ..The aim of this study was to assess whether the shift from regular to low volume blood collection tubes may reduce the rate of hemolysis in a large urban ED, where approximately 80% of blood collections are performed through catheters...
  3. ncbi Adiponectin and migraine: systematic review of clinical evidence
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    Neurol Sci 35:1167-71. 2014
    ..Further larger studies are needed to firmly establish the existence of a relationship between adiponectin metabolism and migraine. ..
  4. ncbi Lack of harmonization of red blood cell distribution width (RDW). Evaluation of four hematological analyzers
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Italy Electronic address
    Clin Biochem 47:1100-3. 2014
    ..To assess analytical imprecision and comparability of red blood cell distribution width (RDW) on Abbott Sapphire, Mindray BC6800, Siemens Advia 2120 and Sysmex XE-5000...
  5. ncbi Homocysteine and migraine. A narrative review
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy Electronic address
    Clin Chim Acta 433:5-11. 2014
    ..Although this evidence must be obviously confirmed in larger trials, some putative mechanisms may support a causal link between increased generation of homocysteine in the brain environment and migraine. ..
  6. ncbi Urgent monitoring of direct oral anticoagulants in patients with atrial fibrillation: a tentative approach based on routine laboratory tests
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    J Thromb Thrombolysis 38:269-74. 2014
    ..According to literature data, this strategy appears suitable to reliably define the thrombotic or bleeding risk in an urgent setting, contextually saving precious laboratory resources. ..
  7. ncbi Early kinetics of heart-type fatty acid binding protein in patients undergoing dipyridamole stress echocardiography and relationship with high-sensitivity troponin
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Haematology, Academic Hospital of Parma, Parma, Italy
    Kardiol Pol 72:527-33. 2014
    ....
  8. ncbi Biological markers in older people at risk of mobility limitations
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Via Gramsci, 14, 43126 Parma, Italy
    Curr Pharm Des 20:3222-44. 2014
    ..In the foreseeable future, proteomic studies might predictably help identify novel associations between putative biomarkers and functional decline...
  9. pmc Interference of medical contrast media on laboratory testing
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    Biochem Med (Zagreb) 24:80-8. 2014
    ..Since the elimination half-life of these compounds is typically lower than 2 h, blood collection after this period may be a safer alternative in patients who have received contrast media for diagnostic purposes. ..
  10. pmc Avoidance to wipe alcohol before venipuncture is not a source of spurious hemolysis
    Gian Luca Salvagno
    Department of Life and Reproduction Sciences, University of Verona, Verona, Italy
    Biochem Med (Zagreb) 23:201-5. 2013
    ..It is still uncertain whether or not avoidance to let disinfectant alcohol dry at the site of venipuncture is a source of spurious hemolysis when drawing venous blood...
  11. doi Laboratory diagnostics of spontaneous bacterial peritonitis
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy Electronic address
    Clin Chim Acta 430:164-70. 2014
    ..The proposed strategy entails, in sequential steps, serum procalcitonin testing, automated cell count in peritoneal fluid, manual cell count in peritoneal fluid, peritoneal fluid culture and bacterial DNA testing in peritoneal fluid. ..
  12. doi Reference range of hemolysis index in serum and lithium-heparin plasma measured with two analytical platforms in a population of unselected outpatients
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy Electronic address
    Clin Chim Acta 429:143-6. 2014
    ..This study was hence planned to establish the reference ranges of HI in serum and lithium-heparin plasma in a population of unselected outpatients, using two analytical platforms...
  13. ncbi Association of red blood cell distribution width with plasma lipids in a general population of unselected outpatients
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Haematology, Department of Pathology and Laboratory Medicine, Academic Hospital of Parma, Italy
    Kardiol Pol 71:931-6. 2013
    ..Nevertheless, limited and controversial information exists on the association between anisocytosis and plasma lipids...
  14. pmc Reduction of gross hemolysis in catheter-drawn blood using Greiner Holdex tube holder
    Giuseppe Lippi
    Clinical Chemistry Laboratory, Academic Hospital of Parma, Parma, Italy
    Biochem Med (Zagreb) 23:303-7. 2013
    ....
  15. doi Influence of spurious hemolysis on blood gas analysis
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Haematology, Department of Pathology and Laboratory Medicine, Academic Hospital of Parma, 43126 Parma, Italy
    Clin Chem Lab Med 51:1651-4. 2013
    ..This study was hence planned to assess the influence of spurious hemolysis on venous blood gas analysis...
  16. doi The syndrome of the "obsessive-compulsory scientist": a new mental disorder?
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy
    Clin Chem Lab Med 51:1575-7. 2013
    ....
  17. ncbi Sample collection and platelet function testing: influence of vacuum or aspiration principle on PFA-100 test results
    Giuseppe Lippi
    Unità Operativa Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Blood Coagul Fibrinolysis 24:666-9. 2013
    ..Different reference ranges of both CEPI and CADP may also be advisable when venous blood samples are collected with manual aspiration or vacuum principle...
  18. doi Systematical assessment of serum indices does not impair efficiency of clinical chemistry testing: a multicenter study
    Giuseppe Lippi
    Unità Operativa Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Clin Biochem 46:1281-4. 2013
    ..A multicenter investigation was planned to verify TAT and performance of serum indices on five different clinical chemistry analyzers...
  19. pmc Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters
    Giuseppe Lippi
    Unità Operativa Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Biochem Med (Zagreb) 23:193-200. 2013
    ..Since blood drawing through intravenous catheters is reported as a potential source of erythrocyte injury, we performed a critical review and meta-analysis about the risk of catheter-related hemolysis...
  20. doi Evaluation of the fully automated hematological analyzer Sysmex XE-5000 for flow cytometric analysis of peritoneal fluid
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    J Lab Autom 18:240-4. 2013
    ....
  21. doi Controlling sources of preanalytical variability in doping samples: challenges and solutions
    Giuseppe Lippi
    Unità Operativa di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Bioanalysis 5:1571-82. 2013
    ....
  22. doi Interference in coagulation testing: focus on spurious hemolysis, icterus, and lipemia
    Giuseppe Lippi
    Dipartimento di Patologia e Medicina di Laboratorio, U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, 43100 Parma, Italy
    Semin Thromb Hemost 39:258-66. 2013
    ..e., > 1,000 mg/dL) using high speed microcentrifugation or lipid extraction with organic solvents such as fluorine-chlorinated hydrocarbon, or lipid-clearing agents such as LipoClear (StatSpin Inc., Norwood, MA) and n-hexane...
  23. doi Continuous-flow automation and hemolysis index: a crucial combination
    Giuseppe Lippi
    Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Via Gramsci 14, Parma, Italy
    J Lab Autom 18:184-8. 2013
    ..The routine implementation of these technical tools in clinical laboratories equipped with continuous-flow automation carries several advantages and some drawbacks that are discussed in this article...
  24. doi Influence of in vitro hemolysis on nucleated red blood cells and reticulocyte counts
    G Lippi
    Dipartimento di Patologia e Medicina di Laboratorio, U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Int J Lab Hematol 35:225-8. 2013
    ..Nucleated red blood cells (NRBCs) and reticulocytes are early and important measures of red blood cells' (RBCs) turnover, but little is known on how spurious hemolysis may affect the reliability of these parameters...
  25. doi Prevention of hemolysis in blood samples collected from intravenous catheters
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    Clin Biochem 46:561-4. 2013
    ..We planned a prospective, randomized study to establish whether hemolysis in samples drawn from intravenous catheters may be reduced using S-Monovette® tubes collected by manual aspiration as compared with standard vacuum tubes...
  26. doi Diagnosis and management of ischemic heart disease
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    Semin Thromb Hemost 39:202-13. 2013
    ..Stem cell-based therapy has also emerged as a potentially therapeutic option, and there are ongoing efforts among several investigators to translate basic research into clinical practice...
  27. doi Massive posttraumatic bleeding: epidemiology, causes, clinical features, and therapeutic management
    Giuseppe Lippi
    Dipartimento di Patologia e Medicina di Laboratorio, U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
    Semin Thromb Hemost 39:83-93. 2013
    ..g., tranexamic acid), and/or procoagulant agents such as fresh frozen plasma, prothrombin complex concentrate, or recombinant-activated Factor VII...
  28. doi Novel and emerging therapies: thrombus-targeted fibrinolysis
    Giuseppe Lippi
    Dipartimento di Patologia e Medicina di Laboratorio, U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
    Semin Thromb Hemost 39:48-58. 2013
    ....
  29. doi Laboratory hemostasis: milestones in Clinical Chemistry and Laboratory Medicine
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Clin Chem Lab Med 51:91-7. 2013
    ....
  30. doi Preanalytical quality improvement: in quality we trust
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Clin Chem Lab Med 51:229-41. 2013
    ..Auditing of the preanalytical phase by ISO assessors and external quality assessment for preanalytical phase are also discussed...
  31. doi Mean platelet volume in patients with ischemic heart disease: meta-analysis of diagnostic studies
    Giuseppe Lippi
    Unità Operativa Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Blood Coagul Fibrinolysis 24:216-9. 2013
    ....
  32. pmc Evaluation of sample hemolysis in blood collected by S-Monovette using vacuum or aspiration mode
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Biochem Med (Zagreb) 23:64-9. 2013
    ..This study was aimed to compare the probability of hemolysis by drawing blood with a commercial evacuated blood collection tube, and S-Monovette used either in the "vacuum" or "aspiration" mode...
  33. pmc Glycogen phosphorylase isoenzyme BB in the diagnosis of acute myocardial infarction: a meta-analysis
    Giuseppe Lippi
    Unità Operativa Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Biochem Med (Zagreb) 23:78-82. 2013
    ..Among innovative and promising biomarkers, the recent interest raised on glycogen phosphorylase isoenzyme BB (GPBB) has prompted us to perform a meta-analysis of published studies...
  34. doi Assessment of neutrophil gelatinase-associated lipocalin and lactate dehydrogenase in peritoneal fluids for the screening of bacterial peritonitis
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    Clin Chim Acta 418:59-62. 2013
    ..However, this approach carries several drawbacks, so that the use of simple and automated tests may be a viable option for initial screening of peritoneal fluids...
  35. doi Biomarkers of myocardial ischemia in the emergency room: cardiospecific troponin and beyond
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Italy
    Eur J Intern Med 24:97-9. 2013
    ....
  36. ncbi Relationship between sampling volume of primary serum tubes and spurious hemolysis
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
    Clin Lab 58:1187-91. 2012
    ..We planned a study to establish whether spurious hemolysis may be present in low volume tubes or partially filled tubes...
  37. doi Critical review and meta-analysis on the combination of heart-type fatty acid binding protein (H-FABP) and troponin for early diagnosis of acute myocardial infarction
    Giuseppe Lippi
    Unità Operativa di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Clin Biochem 46:26-30. 2013
    ..Further studies are needed to assess the diagnostic effectiveness of combining H-FABP with a high-sensitivity troponin immunoassay...
  38. doi Evaluation of white blood cell count in peritoneal fluid with five different hemocytometers
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Italy
    Clin Biochem 46:173-6. 2013
    ..Evaluation of automated flow cytometric analysis of white blood cell (WBC) count in peritoneal fluids...
  39. doi Troponin I measured with a high sensitivity immunoassay is significantly increased after a half marathon run
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Scand J Clin Lab Invest 72:467-70. 2012
    ..These results attest that TnI values measured with the novel HS-AccuTnI immunoassay were significantly increased in athletes participating in a half marathon...
  40. ncbi Quality standards for sample collection in coagulation testing
    Giuseppe Lippi
    Department of Pathology and Laboratory Medicine, Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
    Semin Thromb Hemost 38:565-75. 2012
    ....
  41. ncbi Variation of serum and urinary neutrophil gelatinase associated lipocalin (NGAL) after strenuous physical exercise
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Clin Chem Lab Med 50:1585-9. 2012
    ..As less is known about the potential renal impairment after long distance running, we assessed creatinine and neutrophil gelatinase associated lipocalin (NGAL) in serum (sNGAL) and urine (uNGAL) before and after an ultramarathon...
  42. ncbi Evaluation of NGAL Test™, a fully-automated neutrophil gelatinase-associated lipocalin (NGAL) immunoassay on Beckman Coulter AU 5822
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Clin Chem Lab Med 50:1581-4. 2012
    ..The neutrophil gelatinase associated lipocalin (NGAL) has been identified as the most promising biomarker of acute kidney injury (AKI). This study was aimed to evaluate a NGAL immunoassay on Beckman Coulter AU 5822...
  43. pmc Foot-strike haemolysis after a 60-km ultramarathon
    Giuseppe Lippi
    Unit of Diagnostic Blood Chemistry, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy
    Blood Transfus 10:377-83. 2012
    ..The effective contribution of foot-strike haemolysis is unclear...
  44. ncbi Paradoxical thrombosis, part 2: anticoagulant and antiplatelet therapy
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Via Gramsci, 14, 43126, Parma, Italy
    J Thromb Thrombolysis 34:367-73. 2012
    ..e. heparin-induced thrombocytopenia), or antiplatelet agents such as aspirin, glycoprotein IIb/IIIa inhibitors or clopidogrel, and mostly attributable to direct effect of the agent...
  45. ncbi Paradoxical thrombosis part 1: factor replacement therapy, inherited clotting factor deficiencies and prolonged APTT
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy
    J Thromb Thrombolysis 34:360-6. 2012
    ....
  46. ncbi Identification of spurious hemolysis in anticoagulated blood with Sysmex XE-2100 and Siemens Advia 2120
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Clin Lab 58:801-4. 2012
    ..The aim of this study was to identify simple hematological parameters that would help identify the presence of hemolysis in anticoagulated blood...
  47. doi Inherited disorders of blood coagulation
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Ann Med 44:405-18. 2012
    ..The aim of this article is to provide a general overview on the pathophysiology, clinics, diagnostics, and therapy of inherited disorders of coagulation factors...
  48. ncbi Spurious hemolysis does not influence the reliability of digoxin testing on Siemens RXL MAX and Roche Cobas e601
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Ann Clin Lab Sci 42:302-6. 2012
    ..No significant variation was observed by measuring plasma digoxin on Roche Cobas...
  49. ncbi Highly sensitive troponin immunoassays: navigating between the scylla and charybdis
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Adv Clin Chem 58:1-29. 2012
    ....
  50. doi Influence of mechanical hemolysis of blood on two D-dimer immunoassays
    Giuseppe Lippi
    UO Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Blood Coagul Fibrinolysis 23:461-3. 2012
    ..e. cell-free hemoglobin of 11.5 g/l) confirms that both methods are robust against this type of interference, so that test results might be released in the majority of mildly hemolyzed samples...
  51. ncbi Incomplete filling of lithium heparin tubes affects the activity of creatine kinase and gamma-glutamyltransferase
    G Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
    Br J Biomed Sci 69:67-70. 2012
    ..3% and 16.6% for the half-draw and low-draw tubes, respectively. These results suggest that short-draw lithium heparin tubes might be unsuitable for testing GGT and CK using specific combinations of reagents and instrumentation...
  52. ncbi Biochemical and genetic markers of erectile dysfunction
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologiae Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Adv Clin Chem 57:139-62. 2012
    ..Nevertheless, further research in this area should be encouraged, since the first promising evidence that gene therapy might be effective to restore the decline in ED has been provided in the animal model...
  53. ncbi Influence of hemolysis on troponin testing: studies on Beckman Coulter UniCel Dxl 800 Accu-TnI and overview of the literature
    Giuseppe Lippi
    UO Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Clin Chem Lab Med 49:2097-100. 2011
    ..Hemolyzed specimens are the leading pre-analytical problem in the laboratory practice, and exert a negative impact on test results. We assessed the reliability of Beckman Coulter UniCel Dxl 800 Accu-TnI testing on hemolyzed specimens...
  54. ncbi Considerations for early acute myocardial infarction rule-out for emergency department chest pain patients: the case of copeptin
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliera di Parma, Parma, Italy
    Clin Chem Lab Med 50:243-53. 2012
    ..The aim of this article is to review current evidence about the clinical significance of copeptin testing in the ED as well as its appropriate placing within diagnostic protocols...
  55. ncbi Interference studies: focus on blood cell lysates preparation and testing
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Clin Lab 58:351-5. 2012
    ..The identification of reliable limits for establishing whether a certain degree of hemolysis in the specimen would produce a clinically significant bias in the test system is thereby crucial...
  56. doi Comparison of conventional and highly-sensitive troponin I measurement in ultra-marathon runners
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, Parma, Italy
    J Thromb Thrombolysis 33:338-42. 2012
    ..Moreover, the improved sensitivity of the HS-AccuTnI over the conventional assay makes it more suited for detecting even minor elevations of TnI in blood...
  57. doi Hemostatic properties of the lymph: relationships with occlusion and thrombosis
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 38:213-21. 2012
    ....
  58. doi Degradation of troponin I in serum or plasma: mechanisms, and analytical and clinical implications
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Semin Thromb Hemost 38:222-9. 2012
    ....
  59. doi Influence of in vitro hemolysis on hematological testing on Advia 2120
    G Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Int J Lab Hematol 34:179-84. 2012
    ..Although there is broad knowledge on the effect of several preanalytical errors on laboratory hematology, there is no information on the reliability of routine hematological testing on hemolyzed specimens...
  60. doi Laboratory diagnosis of acute pancreatitis: in search of the Holy Grail
    Giuseppe Lippi
    Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
    Crit Rev Clin Lab Sci 49:18-31. 2012
    ..The promising results of recent proteomics studies showed that this innovative technique might allow the identification of changes characterizing pancreatic tissue injury, thus highlighting new potential biomarkers of acute pancreatitis...
  61. ncbi Studies on in vitro hemolysis and utility of corrective formulas for reporting results on hemolyzed specimens
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Biochem Med (Zagreb) 21:297-305. 2011
    ..Corrective formulas have been proposed to allow the laboratory to release test results on these specimens. This study aimed to assess the influence of spurious hemolysis and reliability of corrective formulas...
  62. ncbi Erythrocyte mechanical fragility is increased in patients with type 2 diabetes
    Giuseppe Lippi
    Clinical Chemistry and Hematology Laboratory, Department of Pathology and Laboratory Medicine, Academic Hospital of Parma, Parma, Italy
    Eur J Intern Med 23:150-3. 2012
    ..Anemia is common among patients with type 2 diabetes. We determined whether type 2 diabetic patients significantly differed in erythrocyte mechanical fragility as compared with nondiabetic subjects...
  63. pmc Non-commutability of results of highly sensitive troponin I and T immunoassays
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Biochem Med (Zagreb) 22:127-9. 2012
    ..However, no information is available on the commutability of results between the novel highly-sensitive (HS) troponin T (TnT) and I (TnI) immunoassays...
  64. ncbi Genetic and clinical aspects of Brugada syndrome: an update
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Adv Clin Chem 56:197-208. 2012
    ..Although molecular genetic testing is effective in detecting mutations in 20-38% of BS patients, it represents an appealing option for stratifying the risk of adverse events as well as for prenatal testing...
  65. ncbi Analytical performance of the new ACL AcuStar HemosIL D-Dimer
    Giuseppe Lippi
    Dipartimento di Patologia e Medicina di Laboratorio, U O di Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
    Blood Coagul Fibrinolysis 23:164-7. 2012
    ..As such, its technical and analytical performance would make it a suitable method for the rapid and accurate quantification of D-dimer in clinical laboratories...
  66. ncbi Optimal therapy for reduction of lipoprotein(a)
    G Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    J Clin Pharm Ther 37:1-3. 2012
    ..We comment on novel strategies for reducing Lp(a) levels...
  67. doi Influence of mechanical trauma of blood and hemolysis on PFA-100 testing
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Blood Coagul Fibrinolysis 23:82-6. 2012
    ..Mechanical trauma of blood causing hemolysis makes PFA-100 testing unreliable. When flow obstructions are observed, the potential presence of hemolysis should be investigated...
  68. doi Holiday thrombosis
    Giuseppe Lippi
    Dipartimento di Patologia e Medicina di Laboratorio, UO Diagnostica Ematochimica, Parma, Italy
    Semin Thromb Hemost 37:869-74. 2011
    ..Many (if not all) patients may ignore such advice and carry on regardless, but they should be given the benefit of informed choice...
  69. ncbi Cardiac troponins and physical exercise. It's time to make a point
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Biochem Med (Zagreb) 21:55-62. 2011
    ..e., serial measurement of cardiac biomarkers, detailed clinical history-taking, integration with ECG and imaging findings) to prevent misdiagnosis of ACS and/or MI in otherwise healthy persons...
  70. ncbi Biochemistry and physiology of anabolic androgenic steroids doping
    G Lippi
    UO Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Mini Rev Med Chem 11:362-73. 2011
    ..The aim of this article is to review the biochemistry, physiology and the ergogenic effects of AASs...
  71. doi Disseminated intravascular coagulation in burn injury
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Parma, Italy
    Semin Thromb Hemost 36:429-36. 2010
    ..Although early prophylaxis with antithrombin concentrates holds promises, especially in the acute phase of thermal injury, larger clinical trials are needed to confirm the benefit of this therapeutic approach...
  72. doi Prevention of venous thromboembolism: focus on mechanical prophylaxis
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 37:237-51. 2011
    ....
  73. doi Glycoprotein IIb/IIIa inhibitors: an update on the mechanism of action and use of functional testing methods to assess antiplatelet efficacy
    Giuseppe Lippi
    UO di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Biomark Med 5:63-70. 2011
    ..As such, the aim of this article is to provide an update on the mechanism of action and use of functional testing methods to assess antiplatelet efficacy in patients undergoing therapy with GPIIb/IIIa antagonists...
  74. ncbi Venous thromboembolism in chronic liver disease
    Giuseppe Lippi
    UO di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 37:66-76. 2011
    ..The clinical significance of an increased risk of venous thromboembolism in CLD is an important topic for future research, and the initiation of new randomized studies of potential treatments for this complication is needed...
  75. doi Screening and therapeutic management of lipoprotein(a) excess: review of the epidemiological evidence, guidelines and recommendations
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Clin Chim Acta 412:797-801. 2011
    ..g., 1.0-3.0 g/day)...
  76. doi Inherited and acquired factor V deficiency
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Blood Coagul Fibrinolysis 22:160-6. 2011
    ..The aim of the current review is to provide an overview on the physiopathology, diagnostics, and clinical management of both inherited and acquired factor V deficiency...
  77. ncbi [The clinical role of high-sensitive troponin assays: update, interpretation, and perspectives]
    Giuseppe Lippi
    UO Diagnostica Ematochimica, Azienda Ospedaliero Universitaria, Parma
    Recenti Prog Med 101:423-8. 2010
    ..In this context, a close partnership between the clinics and the laboratory is an essential aspect for the appropriate use of the tests and for the accurate interpretation of results...
  78. doi Prostate-specific antigen, prostate cancer, and disorders of hemostasis
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospadaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 35:654-64. 2009
    ....
  79. ncbi Cocaine in acute myocardial infarction
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologiae Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Adv Clin Chem 51:53-70. 2010
    ..This strategy might be helpful to adopt the best therapeutic approach for reducing the risks associated with cardiovascular disease in these patients, and also to deter relapse...
  80. doi Disseminated intravascular coagulation in trauma injuries
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Parma, Italy
    Semin Thromb Hemost 36:378-87. 2010
    ..The resulting burst of systemic thrombin generation, coupled with platelet hyperaggregability, shock, hypothermia, and tissue hypoperfusion, further contribute to the development of DIC and microvascular bleeding...
  81. ncbi Shortened activated partial thromboplastin time: causes and management
    Giuseppe Lippi
    Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Blood Coagul Fibrinolysis 21:459-63. 2010
    ..If the value is systematically confirmed in subsequent samples, please contact the laboratory to help assess the cause'...
  82. doi Preanalytical quality improvement: from dream to reality
    Giuseppe Lippi
    Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
    Clin Chem Lab Med 49:1113-26. 2011
    ....
  83. doi Influence of temperature and period of freezing on the generation of hemolysate and blood cell lysate
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Clin Biochem 44:1267-9. 2011
    ..There is little information on temperature and period of freezing for generating hemolysate and blood cell lysate...
  84. doi Unusual false-positive case of urinary screening for buprenorphine
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    J Clin Lab Anal 25:244-5. 2011
    ....
  85. doi Significant variation of traditional markers of liver injury after a half-marathon run
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Eur J Intern Med 22:e36-8. 2011
    ..As such, this study was undertaken to assess the kinetics of liver injury markers following physical exercise...
  86. doi Arterial thrombus formation in cardiovascular disease
    Giuseppe Lippi
    Clinical Chemistry Laboratory, Academic Hospital, University of Parma, Via Gramsci 14, 43126 Parma, Italy
    Nat Rev Cardiol 8:502-12. 2011
    ..This Review explains mechanisms of pathological arterial thrombus formation and discusses genetic and acquired risk factors of atherothrombosis...
  87. doi Hemolyzed specimens: a major challenge for emergency departments and clinical laboratories
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Crit Rev Clin Lab Sci 48:143-53. 2011
    ..g. by using the hemolysis index), differentiating in vitro from in vivo hemolysis, troubleshooting the potential causes, and maintaining good relations between the clinical laboratory and the ED...
  88. ncbi Multicenter evaluation of the hemolysis index in automated clinical chemistry systems
    Giuseppe Lippi
    Clinical Chemistry Laboratory, University of Verona, Verona, Italy
    Clin Chem Lab Med 47:934-9. 2009
    ....
  89. doi Extracorporeal immunoadsorption for the treatment of coagulation inhibitors
    Massimo Franchini
    Immunohematology and Transfusion Center, University Hospital of Parma, Parma, Italy
    Semin Thromb Hemost 35:76-80. 2009
    ..However, further randomized clinical trials are needed to better assess the cost-effectiveness of such procedures...
  90. doi Hemophilia and cancer: a new challenge for hemophilia centers
    Massimo Franchini
    Immunohematology and Transfusion Center Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy
    Cancer Treat Rev 35:374-7. 2009
    ..These aspects, along with the epidemiology of cancer in hemophiliacs will be discussed in this review...
  91. doi Interpatient phenotypic inconsistency in severe congenital hemophilia: a systematic review of the role of inherited thrombophilia
    Massimo Franchini
    Department of Pathology and Laboratory Medicine, Immunohematology and Transfusion Center, University Hospital of Parma, Italy
    Semin Thromb Hemost 35:307-12. 2009
    ..Further trials on a large population of patients are needed to establish the role of genetic thrombophilia in the phenotypic expression of severe hemophilia...
  92. doi The bidirectional relationship of cancer and hemostasis and the potential role of anticoagulant therapy in moderating thrombosis and cancer spread
    Massimo Franchini
    Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy
    Semin Thromb Hemost 35:644-53. 2009
    ..The main biological and clinical evidence on the relationship between cancer and hemostasis are briefly summarized in this review, as is the potential benefits of anticoagulant therapy in this setting...
  93. doi Von Willebrand factor-containing factor VIII concentrates and inhibitors in haemophilia A. A critical literature review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Thromb Haemost 104:931-40. 2010
    ..As a result, we have not found definitive evidence supporting a role for product type on inhibitor incidence and inhibitor eradication in haemophilia A patients...
  94. doi The use of recombinant activated FVII in postpartum hemorrhage
    Massimo Franchini
    Department of Pathology and Laboratory Medicine, University Hospital of Parma, Immunohematology and Transfusion Center, Parma, Italy
    Clin Obstet Gynecol 53:219-27. 2010
    ..Finally, on the basis of the evidence from the literature and on own experience, we included some recommendations and an algorithm on the therapeutic role of rFVIIa in the management of PPH...
  95. doi Prophylaxis in congenital hemophilia with inhibitors: the role of recombinant activated factor VII
    Massimo Franchini
    Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 35:814-9. 2009
    ..The published data on the use of rFVIIa as a prophylactic treatment in hemophilia patients with inhibitors are reviewed in this article...
  96. doi Evaluation of the analytical performances of the novel Beckman Coulter AU5800
    Giuseppe Lippi
    UO Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
    Clin Biochem 45:502-4. 2012
    ..To assess the analytical performance of Beckman Coulter AU5800...
  97. doi The use of desmopressin in congenital factor XI deficiency: a systematic review
    Massimo Franchini
    Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Ann Hematol 88:931-5. 2009
    ..However, these findings need to be supported by further trials on large population of patients...
  98. doi Ex-vivo red blood cells generation: a step ahead in transfusion medicine?
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Eur J Intern Med 22:16-9. 2011
    ....
  99. doi Haemolysis: an overview of the leading cause of unsuitable specimens in clinical laboratories
    Giuseppe Lippi
    Clinical Chemistry Laboratory, University of Verona, Verona, Italy
    Clin Chem Lab Med 46:764-72. 2008
    ....
  100. doi Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox"
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 36:59-70. 2010
    ....