F Licastro

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Acute myocardial infarction and proinflammatory gene variants
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, Bologna Italy
    Ann N Y Acad Sci 1119:227-42. 2007
  2. ncbi Brain immune responses cognitive decline and dementia: relationship with phenotype expression and genetic background
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126, Bologna, Italy
    Mech Ageing Dev 124:539-48. 2003
  3. ncbi Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Neurobiol Aging 24:921-6. 2003
  4. ncbi The concomitant presence of polymorphic alleles of interleukin-1beta, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men. Results from a pilot study
    Federico Licastro
    Department of Experimental Pathology, Via S Giacomo 14, 40126 Bologna, Italy
    Mech Ageing Dev 125:575-9. 2004
  5. ncbi A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Neurobiol Aging 26:449-53. 2005
  6. ncbi Alpha 1 antichymotrypsin genotype is associated with increased risk of prostate carcinoma and PSA levels
    Federico Licastro
    Department of Experimental Pathology, University of Bologna Via S Giacomo 14, 40126 Bologna, Italy
    Anticancer Res 28:395-9. 2008
  7. doi Multivariable network associated with cognitive decline and dementia
    Federico Licastro
    Department of Experimental Pathology, 40126 Bologna, Italy
    Neurobiol Aging 31:257-69. 2010
  8. ncbi Immune-endocrine status and coeliac disease in children with Down's syndrome: relationships with zinc and cognitive efficiency
    F Licastro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Brain Res Bull 55:313-7. 2001
  9. ncbi Altered cytokine and acute phase response protein levels in the blood of children with Downs syndrome: relationship with dementia of Alzheimer's type
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    Int J Immunopathol Pharmacol 18:165-72. 2005
  10. ncbi A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Neurobiol Aging 25:1017-22. 2004

Detail Information

Publications60

  1. ncbi Acute myocardial infarction and proinflammatory gene variants
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, Bologna Italy
    Ann N Y Acad Sci 1119:227-42. 2007
    ..This information may better define the pathogenesis of myocardial infarction and identify individuals who might benefit from early interventions...
  2. ncbi Brain immune responses cognitive decline and dementia: relationship with phenotype expression and genetic background
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126, Bologna, Italy
    Mech Ageing Dev 124:539-48. 2003
    ....
  3. ncbi Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Neurobiol Aging 24:921-6. 2003
    ..Both the -174 CC and VNTR DD genotypes were also associated with increased IL-6 levels in the blood and brain from AD. These findings suggest that IL-6 may play a multifaceted role in AD by affecting the turnover of the cytokine...
  4. ncbi The concomitant presence of polymorphic alleles of interleukin-1beta, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men. Results from a pilot study
    Federico Licastro
    Department of Experimental Pathology, Via S Giacomo 14, 40126 Bologna, Italy
    Mech Ageing Dev 125:575-9. 2004
    ..The administration of anti-inflammatory compounds to middle age healthy subjects with increased genetic susceptibility of developing MI might decrease the incidence and prevalence of cardiovascular events in aging...
  5. ncbi A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Neurobiol Aging 26:449-53. 2005
    ..The ACT gene appears to influence the early clinical development of the disease, and the interaction of the ACT and APOE genes affects clinical progression of AD...
  6. ncbi Alpha 1 antichymotrypsin genotype is associated with increased risk of prostate carcinoma and PSA levels
    Federico Licastro
    Department of Experimental Pathology, University of Bologna Via S Giacomo 14, 40126 Bologna, Italy
    Anticancer Res 28:395-9. 2008
    ..Recent studies have shown that many inflammatory genes are associated with the risk of PCa. Alpha 1 antichymotrypsin (ACT) is an acute phase protein and it is part of the circulating prostate specific antigen (PSA)...
  7. doi Multivariable network associated with cognitive decline and dementia
    Federico Licastro
    Department of Experimental Pathology, 40126 Bologna, Italy
    Neurobiol Aging 31:257-69. 2010
    ..This data analysis method was compared with another mathematical model called mutual information relevance network and results are presented and discussed...
  8. ncbi Immune-endocrine status and coeliac disease in children with Down's syndrome: relationships with zinc and cognitive efficiency
    F Licastro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Brain Res Bull 55:313-7. 2001
    ..Altered intestinal absorption of nutrients may in turn affect endocrine functions, brain development, and cognitive performances...
  9. ncbi Altered cytokine and acute phase response protein levels in the blood of children with Downs syndrome: relationship with dementia of Alzheimer's type
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    Int J Immunopathol Pharmacol 18:165-72. 2005
    ..Peripheral altered immune phenotype in healthy young subjects with DS might be an early sign of CNS alterations leading many years later to cognitive deterioration and dementia...
  10. ncbi A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Neurobiol Aging 25:1017-22. 2004
    ..Our findings suggest that IL-1beta gene by affecting brain immune responses may influence the age at onset of the disease, survival and AD progression...
  11. ncbi Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    J Neuroimmunol 103:97-102. 2000
    ..Detection of these molecules might be used for monitoring the progression of brain inflammation associated with AD...
  12. ncbi Blood levels of alpha-1-antichymotrypsin and risk factors for Alzheimer's disease: effects of gender and apolipoprotein E genotype
    F Licastro
    Dipartimento di Patologia Sperimentale, University of Bologna, Italy
    Dement Geriatr Cogn Disord 11:25-8. 2000
    ..The gender effect appeared to be prominent, since female AD patients with APOE 3,3 had similar ACT levels to those of female AD patients with APOE 4,4...
  13. ncbi Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease
    F Licastro
    Dipartimento di Patologia Sperimentale, School of Medicine, University of Bologna, Italy
    Neurosci Lett 270:129-32. 1999
    ..Present findings indicated that subjects with ACT TT genotype had an increased risk of developing AD and suggested that this genotype influenced the risk of an early onset of the disease by affecting the production of ACT molecules...
  14. ncbi Altered vessel signalling molecules in subjects with Downs syndrome
    F Licastro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Int J Immunopathol Pharmacol 19:181-5. 2006
    ..An altered regulation of these molecules might interfere with some processes involved in cognitive performances of DS subjects...
  15. ncbi Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype
    F Licastro
    Dipartimento di Patologia Sperimentale, University of Bologna, Italy
    J Neuroimmunol 88:105-10. 1998
    ..Elevated ACT levels in the brain of AD patients could be interpreted as a metabolic response of astrocytes which might modulate the potentially deleterious activation of microglia cells...
  16. ncbi Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart
    F Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Italy
    Curr Pharm Des 16:783-8. 2010
    ....
  17. ncbi Elevated plasma levels of alpha-1-anti-chymotrypsin in age-related cognitive decline and Alzheimer's disease: a potential therapeutic target
    E Porcellini
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Curr Pharm Des 14:2659-64. 2008
    ..The development of compounds able to interfere with the ACT biological activity (protease inhibition and/or promotion of amyloid deposition) might have therapeutic relevance for the disease...
  18. ncbi Polymorphisms of fas gene: relationship with Alzheimer's disease and cognitive decline
    M Chiappelli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Dement Geriatr Cogn Disord 22:296-300. 2006
    ..Our data suggest that different genetic background in the Fas gene may influence the risk and clinical progression of the disease by affecting neurodegenerative processes leading to neuronal loss...
  19. doi Genetic factors regulating inflammation and DNA methylation associated with prostate cancer
    M Ianni
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    Prostate Cancer Prostatic Dis 16:56-61. 2013
    ....
  20. ncbi Alpha-1-antichymotrypsin and oxidative stress in the peripheral blood from patients with probable Alzheimer disease: a short-term longitudinal study
    F Licastro
    Dipartimento di Patologia Sperimentale, University of Bologna, Italy
    Alzheimer Dis Assoc Disord 15:51-5. 2001
    ..ACT might be implicated in controlling oxidative damage of blood lipids and their turnover during the progression of AD...
  21. ncbi Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men
    M Chiappelli
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Int J Immunogenet 32:349-53. 2005
    ....
  22. ncbi Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Neurobiol Aging 28:1637-43. 2007
    ..We integrated this information to better define risk and determine the relative importance of APOE and immunological mediators...
  23. ncbi The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients
    Emanuela Tumini
    Department of Experimental Pathology, University of Bologna, Italy, Psychiatric Department Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hum Psychopharmacol 22:75-80. 2007
    ..Our findings suggest that the G51S PNP polymorphism is associated with a faster rate of cognitive decline in AD patients, highlighting the important role of purine metabolism in the progression of this neurodegenerative disorder...
  24. ncbi The hydroxy-methyl-glutaryl CoA reductase promoter polymorphism is associated with Alzheimer's risk and cognitive deterioration
    Elisa Porcellini
    Department of Experimental Pathology, School of Medicine University of Bologna, Via San Giacomo 14, Bologna, Italy
    Neurosci Lett 416:66-70. 2007
    ..Present findings reinforce the notion that abnormal regulation of cholesterol metabolism is a key factor in the pathogenesis of the disease...
  25. ncbi Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Aging (Milano) 13:163-70. 2001
    ..The possibility as well as the difficulty in identifying a pro-inflammatory phenotype, and its importance for the prevention, diagnosis and therapy of AD and other age-related pathologies are discussed...
  26. ncbi Proapoptotic activated T-cells in the blood of children with Down's syndrome: relationship with dietary antigens and intestinal alterations
    M M Corsi
    Institute of General Pathology, Laboratory of Clinical Pathology, School of Medicine, University of Milan, Italy
    Int J Tissue React 25:117-25. 2003
    ..An overload of dietary antigens and impaired nutrient absorption secondary to altered functioning of the gastrointestinal mucosa might interfere with normal immune responses by inducing programmed cell death in CD4 T-cells...
  27. ncbi Zinc and thymic hormone-dependent immunity in normal ageing and in patients with senile dementia of the Alzheimer type
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    J Neuroimmunol 27:201-8. 1990
    ..The endocrine function of the thymus of patients with dementia appears to be more compromised than that from aged controls...
  28. pmc A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease
    F Licastro
    Dipartimento di Patologia Sperimentale, University of Bologna, Bologna, Italy
    Am J Pathol 155:869-75. 1999
    ..This is relevant to Alzheimer's disease because these two molecules appear to be closely associated with the pathogenesis of this disorder...
  29. ncbi Oxidated low-density lipoproteins (oxLDL) and peroxides in plasma of Down syndrome patients
    F Licastro
    Department of Experimental Pathology, Laboratory of Immunology, University of Bologna, Bologna, Italy
    Arch Gerontol Geriatr 44:225-32. 2007
    ..Up-regulation of vascular andothelial growth factor (VEGF)-mediated signals and increased nerve growth factor (NGF) expression might be two of these important protective factors...
  30. ncbi Tumor necrosis factor-alpha antagonists: differential clinical effects by different biotechnological molecules
    F Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    Int J Immunopathol Pharmacol 22:567-72. 2009
    ..Differential therapeutic actions of these drugs may be advantageously used in clinical practice and further improve the great potential of individual TNF-alpha inhibitors...
  31. ncbi Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    Neurobiol Aging 27:54-66. 2006
    ....
  32. ncbi Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 84:1473-80. 2006
    ..Homocysteine, another risk factor for vascular disease and dementia, also binds to VLDL in blood. However, the association between APOE4 and hyperhomocysteinemia has never been thoroughly investigated...
  33. ncbi Endogenous sex hormones as risk factors for dementia in elderly men and women
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola, Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    J Gerontol A Biol Sci Med Sci 62:1035-41. 2007
    ..The associations of endogenous sex hormones with risk of dementia in the elderly population are not well known...
  34. ncbi VEGF gene and phenotype relation with Alzheimer's disease and mild cognitive impairment
    Martina Chiappelli
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    Rejuvenation Res 9:485-93. 2006
    ..In addition, the authors investigated whether patterns of association also were found for mild cognitive impairment (MCI) and conversion from MCI to AD...
  35. ncbi Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9, 40138 Bologna, Italy
    Neurobiol Aging 28:1810-20. 2007
    ..91; 95%CI, 1.02-3.56) but not VaD risk. Blood inflammatory markers are associated with increased VaD risk but do not predict AD, which seems selectively associated with hyperhomocysteinemia...
  36. doi Blood inflammatory proteins and risk of incident depression in the elderly
    Paola Forti
    Department of Internal Medicine, Ageing, and Nephrology, University Hospital St Orsola Malpighi, Bologna, Italy
    Dement Geriatr Cogn Disord 29:11-20. 2010
    ..It is unclear whether high levels of blood inflammatory proteins are associated with the risk of developing depression in late life...
  37. pmc Alzheimer's disease gene signature says: beware of brain viral infections
    Elisa Porcellini
    Department of Experimental Pathology, School of Medicine, University of Bologna Italy
    Immun Ageing 7:16. 2010
    ..abstract:..
  38. pmc Predictive diagnostics and personalized medicine for the prevention of chronic degenerative diseases
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S1. 2010
    ..In fact, predictive diagnostics, personalized medicine and personalized therapy have the potential of changing classical approaches of modern medicine to CDD...
  39. ncbi Homocysteine and folate as risk factors for dementia and Alzheimer disease
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 82:636-43. 2005
    ..In cross-sectional studies, elevated plasma total homocysteine (tHcy) concentrations have been associated with cognitive impairment and dementia. Incidence studies of this issue are few and have produced conflicting results...
  40. ncbi Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    Exp Gerontol 41:85-92. 2006
    ..The relationship between the AD risk factor plasma tHcy and the IL-1beta-511 polymorphism was never reported before and might explain previous cross-sectional reports of an association between this polymorphism and AD...
  41. ncbi Associations of the -174 G/C interleukin-6 gene promoter polymorphism with serum interleukin 6 and mortality in the elderly
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138, Bologna, Italy
    Biogerontology 6:415-23. 2005
    ..31, 95%CI: 0.13-0.76]. In conclusion, although associated with increased sIL6 levels in presence of major diseases, the IL6-174 C-allele does not seem to have direct detrimental effects on survival in older age...
  42. pmc Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: a new risk charts for prevention of dementia
    Federico Licastro
    Department of Experimental Pathology, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S4. 2010
    ..CONCLUSION : This map of variables may be use to identify subjects with increased risk of developing cognitive decline end/or dementia and provide pivotal information for early intervention protocols for prevention of dementia...
  43. ncbi Lectins and superantigens: membrane interactions of these compounds with T lymphocytes affect immune responses
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    Int J Biochem 25:845-52. 1993
    ....
  44. ncbi Impaired regulation of immune responses in cognitive decline and Alzheimer's disease: lessons from genetic association studies
    Martina Chiappelli
    University of Bologna, Department of Experimental Pathology, School of Medicine, Via S Giacomo 14, 40126 Bologna, Italy
    Expert Rev Neurother 6:1327-36. 2006
    ..Only this group of patients may benefit from anti-inflammatory treatment...
  45. ncbi Does Down's syndrome support the homocysteine theory of atherogenesis? Experience in elderly subjects with trisomy 21
    Federico Licastro
    Department of Experimental Pathology, Laboratory of Immunology, School of Medicine, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Arch Gerontol Geriatr 43:381-7. 2006
    ..Our results indicate that this group of "healthy old" Down syndrome patients, although showing some classical biochemical risk factors for atherosclerosis, did not suffer clinical cardiovascular alterations...
  46. ncbi Association between the polymorphism of CCR5 and Alzheimer's disease: results of a study performed on male and female patients from Northern Italy
    Carmela Rita Balistreri
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Corso Tukory 211, 90134 Palermo, Italy
    Ann N Y Acad Sci 1089:454-61. 2006
    ..Further, studies should focus on identification of proinflammatory genetic variants involved in AD pathogenesis in women...
  47. ncbi Allele frequencies of +874T --> A single nucleotide polymorphism at the first intron of IFN-gamma gene in Alzheimer's disease patients
    Letizia Scola
    Gruppo di Studio sull Immunosenescenza, Department of Pathobiology and Biomedical Methodologies, University of Palermo, Palermo, Italy
    Aging Clin Exp Res 15:292-5. 2003
    ..To our knowledge, no data have yet been presented on the association between AD and polymorphisms of the interferon(IFN)-gamma gene, despite the pivotal role that IFN-gamma plays in immune-mediated inflammatory responses...
  48. ncbi Association between the HLA-A2 allele and Alzheimer disease
    Florinda Listi
    Immunosenescence Unit, Department of Pathobiology and Biomedical Methodology, University of Palermo, Palermo, Italy
    Rejuvenation Res 9:99-101. 2006
    ..However, it has to be taken into account that there are many molecular HLA-A2 subtypes with different frequencies in various populations. Therefore, further studies should include molecular typing of HLA-A2 subtypes...
  49. ncbi Tumor necrosis factor-alpha -308A/G polymorphism is associated with age at onset of Alzheimer's disease
    Domenico Lio
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie, Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Mech Ageing Dev 127:567-71. 2006
    ....
  50. ncbi Association between the HFE mutations and unsuccessful ageing: a study in Alzheimer's disease patients from Northern Italy
    Giuseppina Candore
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134, Palermo, Italy
    Mech Ageing Dev 124:525-8. 2003
    ..Thus, our study does not support the suggestion that H63D mutations may anticipate sporadic AD clinical presentation in susceptible individuals...
  51. ncbi Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: a pharmacogenomic approach
    Giuseppina Candore
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Mech Ageing Dev 128:67-75. 2007
    ..All together this information may represent the basis both for future recognition of individuals at risk and for the pharmacogenomic driving of drug responsiveness...
  52. ncbi Apolipoprotein E genotypic frequencies among Down syndrome patients imply early unsuccessful aging for ApoE4 carriers
    Giusi I Forte
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università Palermo, Palermo, Italy
    Rejuvenation Res 10:293-9. 2007
    ....
  53. ncbi Plasma nerve growth factor (NGF) and inflammatory cytokines (IL-6 and MCP-1) in young and adult subjects with Down syndrome: an interesting pathway
    Massimiliano M Corsi
    Institute of General Pathology, Laboratory of Clinical Pathology, Medical Faculty, University of Milan, Italy
    Neuro Endocrinol Lett 27:773-8. 2006
    ..Down's syndrome (DS) is the most frequent chromosomal aberration in men and it is invariably associated with mental retardation...
  54. ncbi Association between HFE mutations and acute myocardial infarction: a study in patients from Northern and Southern Italy
    Giuseppina Candore
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Blood Cells Mol Dis 31:57-62. 2003
    ..Thus, our study, performed in two samples of genetically homogeneous patients and controls, does not support the suggestion that HFE mutations may be associated with acute myocardial infarction in susceptible individuals...
  55. ncbi Age-related inflammatory diseases: role of genetics and gender in the pathophysiology of Alzheimer's disease
    Giuseppina Candore
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Corso Tukory 211, 90134 Palermo, Italy
    Ann N Y Acad Sci 1089:472-86. 2006
    ..All together this information may represent the basis both for future recognition of individuals at risk as well as for a pharmacogenomic approach in achieving drug responsiveness...
  56. ncbi Outcomes from a program of home care attendance in very frail elderly subjects
    Raffaele Giannini
    Department of Internal Medicine and Aging, S Orsola Malpighi University Hospital, Via Albertoni 15, 40138 Bologna, Italy
    Arch Gerontol Geriatr 44:95-103. 2007
    ..These outcomes can be related to the additional program of home attendance. The correlation between pro-inflammatory cytokine levels and degree of frailty are observed in both groups without statistically significant difference...
  57. ncbi Anti-dsDNA autoantibodies in serum of Down's syndrome patients
    Massimiliano M Corsi
    Clin Chim Acta 348:219-21. 2004
  58. ncbi Effects of IL6 and IL1beta on aFGF expression and excitotoxicity in NT2N cells
    Veronika Thorns
    Department of Neuropathology, Medical School of Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Neuroimmunol 127:22-9. 2002
    ..These data suggest that (1) IL6 exerts protective functions by upregulating the expression of aFGF and (2) the IL6/IL1beta balance in the brain may regulate neuronal survival during neuropathological processes...
  59. ncbi Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits
    Paolo Zatta
    CNR Center on Metalloproteins, Department of Biology, University of Padova, Italy
    J Alzheimers Dis 4:1-9. 2002
    ..The relevance on the cholesterol metabolism in Alzheimer's disease pathogenesis is also discussed...
  60. ncbi Genetics of neurodegenerative disorders
    Calogero Caruso
    N Engl J Med 349:193-4; author reply 193-4. 2003