F Licastro

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. pmc Monocyte chemoattractant protein-1 promoter polymorphism and plasma levels in alzheimer's disease
    Elisa Porcellini
    DIMES, School of Medicine, University of Bologna, Via S, Giacomo 14, Bologna, 40126, Italy
    Immun Ageing 10:6. 2013
  2. pmc Pro-inflammatory genetic profile and familiarity of acute myocardial infarction
    Manuela Ianni
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S, Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 9:14. 2012
  3. pmc Age-related changes in plasma levels of BDNF in Down syndrome patients
    Giada Dogliotti
    , Laboratory of Clinical Pathology, University of Milan, Milan, Italy
    Immun Ageing 7:2. 2010
  4. pmc Altered glycosylation profile of purified plasma ACT from Alzheimer's disease
    Manuela Ianni
    Department of Experimental Pathology, School of Medicine, University of Bologna, 14 San Giacomo St, 40126 Bologna, Italy
    Immun Ageing 7:S6. 2010
  5. pmc Serum neutrophil gelatinase-B associated lipocalin (NGAL) levels in Down's syndrome patients
    Giada Dogliotti
    Department of Human Morphology and Biomedical Sciences Citta Studi, Laboratory of Clinical Pathology, University of Milan, Milan, Italy
    Immun Ageing 7:S7. 2010
  6. ncbi request reprint Tumor necrosis factor-alpha antagonists: differential clinical effects by different biotechnological molecules
    F Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    Int J Immunopathol Pharmacol 22:567-72. 2009
  7. doi request reprint Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimer's disease as shown by partially overlapping of gene variant profiles
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    J Alzheimers Dis 23:421-31. 2011
  8. pmc Alzheimer's disease gene signature says: beware of brain viral infections
    Elisa Porcellini
    Department of Experimental Pathology, School of Medicine, University of Bologna Italy
    Immun Ageing 7:16. 2010
  9. pmc Predictive diagnostics and personalized medicine for the prevention of chronic degenerative diseases
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S1. 2010
  10. pmc Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: a new risk charts for prevention of dementia
    Federico Licastro
    Department of Experimental Pathology, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S4. 2010

Collaborators

Detail Information

Publications30

  1. pmc Monocyte chemoattractant protein-1 promoter polymorphism and plasma levels in alzheimer's disease
    Elisa Porcellini
    DIMES, School of Medicine, University of Bologna, Via S, Giacomo 14, Bologna, 40126, Italy
    Immun Ageing 10:6. 2013
    ..MCP-1 plasma levels were also measured and correlated to the cognitive impairment (CIND) and AD risk...
  2. pmc Pro-inflammatory genetic profile and familiarity of acute myocardial infarction
    Manuela Ianni
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S, Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 9:14. 2012
    ..abstract:..
  3. pmc Age-related changes in plasma levels of BDNF in Down syndrome patients
    Giada Dogliotti
    , Laboratory of Clinical Pathology, University of Milan, Milan, Italy
    Immun Ageing 7:2. 2010
    ..However, the striking drop in peripheral BDNF levels with age might predispose these patients to clinical manifestations of dementia in later life...
  4. pmc Altered glycosylation profile of purified plasma ACT from Alzheimer's disease
    Manuela Ianni
    Department of Experimental Pathology, School of Medicine, University of Bologna, 14 San Giacomo St, 40126 Bologna, Italy
    Immun Ageing 7:S6. 2010
    ..Moreover ACT glycosylation analysis could be used to predict AD clinical progression and used in clinical trials as surrogate marker of clinical efficacy...
  5. pmc Serum neutrophil gelatinase-B associated lipocalin (NGAL) levels in Down's syndrome patients
    Giada Dogliotti
    Department of Human Morphology and Biomedical Sciences Citta Studi, Laboratory of Clinical Pathology, University of Milan, Milan, Italy
    Immun Ageing 7:S7. 2010
    ..NGAL may have the potential application to ameliorate the toxicity induced by oxidative stress conditions such as Alzheimer's disease, thalassemia, cardiovascular disease, burn injury, transplantation, diabetes, and aging...
  6. ncbi request reprint Tumor necrosis factor-alpha antagonists: differential clinical effects by different biotechnological molecules
    F Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    Int J Immunopathol Pharmacol 22:567-72. 2009
    ..Differential therapeutic actions of these drugs may be advantageously used in clinical practice and further improve the great potential of individual TNF-alpha inhibitors...
  7. doi request reprint Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimer's disease as shown by partially overlapping of gene variant profiles
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    J Alzheimers Dis 23:421-31. 2011
    ....
  8. pmc Alzheimer's disease gene signature says: beware of brain viral infections
    Elisa Porcellini
    Department of Experimental Pathology, School of Medicine, University of Bologna Italy
    Immun Ageing 7:16. 2010
    ..abstract:..
  9. pmc Predictive diagnostics and personalized medicine for the prevention of chronic degenerative diseases
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S1. 2010
    ..In fact, predictive diagnostics, personalized medicine and personalized therapy have the potential of changing classical approaches of modern medicine to CDD...
  10. pmc Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: a new risk charts for prevention of dementia
    Federico Licastro
    Department of Experimental Pathology, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S4. 2010
    ..CONCLUSION : This map of variables may be use to identify subjects with increased risk of developing cognitive decline end/or dementia and provide pivotal information for early intervention protocols for prevention of dementia...
  11. ncbi request reprint Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart
    F Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Italy
    Curr Pharm Des 16:783-8. 2010
    ....
  12. doi request reprint Gene signature in Alzheimer's disease and environmental factors: the virus chronicle
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    J Alzheimers Dis 27:809-17. 2011
    ....
  13. ncbi request reprint Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease
    F Licastro
    Dipartimento di Patologia Sperimentale, School of Medicine, University of Bologna, Italy
    Neurosci Lett 270:129-32. 1999
    ..Present findings indicated that subjects with ACT TT genotype had an increased risk of developing AD and suggested that this genotype influenced the risk of an early onset of the disease by affecting the production of ACT molecules...
  14. ncbi request reprint Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men
    M Chiappelli
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Int J Immunogenet 32:349-53. 2005
    ....
  15. ncbi request reprint Elevated plasma levels of alpha-1-anti-chymotrypsin in age-related cognitive decline and Alzheimer's disease: a potential therapeutic target
    E Porcellini
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Curr Pharm Des 14:2659-64. 2008
    ..The development of compounds able to interfere with the ACT biological activity (protease inhibition and/or promotion of amyloid deposition) might have therapeutic relevance for the disease...
  16. ncbi request reprint Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    J Neuroimmunol 103:97-102. 2000
    ..Detection of these molecules might be used for monitoring the progression of brain inflammation associated with AD...
  17. doi request reprint Genetic factors regulating inflammation and DNA methylation associated with prostate cancer
    M Ianni
    Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
    Prostate Cancer Prostatic Dis 16:56-61. 2013
    ....
  18. ncbi request reprint Altered vessel signalling molecules in subjects with Downs syndrome
    F Licastro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Int J Immunopathol Pharmacol 19:181-5. 2006
    ..An altered regulation of these molecules might interfere with some processes involved in cognitive performances of DS subjects...
  19. ncbi request reprint Polymorphisms of fas gene: relationship with Alzheimer's disease and cognitive decline
    M Chiappelli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Dement Geriatr Cogn Disord 22:296-300. 2006
    ..Our data suggest that different genetic background in the Fas gene may influence the risk and clinical progression of the disease by affecting neurodegenerative processes leading to neuronal loss...
  20. ncbi request reprint Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype
    F Licastro
    Dipartimento di Patologia Sperimentale, University of Bologna, Italy
    J Neuroimmunol 88:105-10. 1998
    ..Elevated ACT levels in the brain of AD patients could be interpreted as a metabolic response of astrocytes which might modulate the potentially deleterious activation of microglia cells...
  21. ncbi request reprint Zinc and thymic hormone-dependent immunity in normal ageing and in patients with senile dementia of the Alzheimer type
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    J Neuroimmunol 27:201-8. 1990
    ..The endocrine function of the thymus of patients with dementia appears to be more compromised than that from aged controls...
  22. ncbi request reprint Alpha-1-antichymotrypsin and oxidative stress in the peripheral blood from patients with probable Alzheimer disease: a short-term longitudinal study
    F Licastro
    Dipartimento di Patologia Sperimentale, University of Bologna, Italy
    Alzheimer Dis Assoc Disord 15:51-5. 2001
    ..ACT might be implicated in controlling oxidative damage of blood lipids and their turnover during the progression of AD...
  23. ncbi request reprint Immune-endocrine status and coeliac disease in children with Down's syndrome: relationships with zinc and cognitive efficiency
    F Licastro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Brain Res Bull 55:313-7. 2001
    ..Altered intestinal absorption of nutrients may in turn affect endocrine functions, brain development, and cognitive performances...
  24. ncbi request reprint Altered cytokine and acute phase response protein levels in the blood of children with Downs syndrome: relationship with dementia of Alzheimer's type
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    Int J Immunopathol Pharmacol 18:165-72. 2005
    ..Peripheral altered immune phenotype in healthy young subjects with DS might be an early sign of CNS alterations leading many years later to cognitive deterioration and dementia...
  25. ncbi request reprint Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Aging (Milano) 13:163-70. 2001
    ..The possibility as well as the difficulty in identifying a pro-inflammatory phenotype, and its importance for the prevention, diagnosis and therapy of AD and other age-related pathologies are discussed...
  26. ncbi request reprint Blood levels of alpha-1-antichymotrypsin and risk factors for Alzheimer's disease: effects of gender and apolipoprotein E genotype
    F Licastro
    Dipartimento di Patologia Sperimentale, University of Bologna, Italy
    Dement Geriatr Cogn Disord 11:25-8. 2000
    ..The gender effect appeared to be prominent, since female AD patients with APOE 3,3 had similar ACT levels to those of female AD patients with APOE 4,4...
  27. ncbi request reprint Oxidated low-density lipoproteins (oxLDL) and peroxides in plasma of Down syndrome patients
    F Licastro
    Department of Experimental Pathology, Laboratory of Immunology, University of Bologna, Bologna, Italy
    Arch Gerontol Geriatr 44:225-32. 2007
    ..Up-regulation of vascular andothelial growth factor (VEGF)-mediated signals and increased nerve growth factor (NGF) expression might be two of these important protective factors...
  28. ncbi request reprint Lectins and superantigens: membrane interactions of these compounds with T lymphocytes affect immune responses
    F Licastro
    Department of Experimental Pathology, University of Bologna, Italy
    Int J Biochem 25:845-52. 1993
    ....
  29. pmc A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease
    F Licastro
    Dipartimento di Patologia Sperimentale, University of Bologna, Bologna, Italy
    Am J Pathol 155:869-75. 1999
    ..This is relevant to Alzheimer's disease because these two molecules appear to be closely associated with the pathogenesis of this disorder...
  30. ncbi request reprint Proapoptotic activated T-cells in the blood of children with Down's syndrome: relationship with dietary antigens and intestinal alterations
    M M Corsi
    Institute of General Pathology, Laboratory of Clinical Pathology, School of Medicine, University of Milan, Italy
    Int J Tissue React 25:117-25. 2003
    ..An overload of dietary antigens and impaired nutrient absorption secondary to altered functioning of the gastrointestinal mucosa might interfere with normal immune responses by inducing programmed cell death in CD4 T-cells...